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David Y-K Chen

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Publications

TOP 3
David Y-K Chen; So Won Youn
C-H activation: a complementary tool in the total synthesis of complex natural products.
David Y-K Chen; Rebecca H Pouwer; Jean-Alexandre Richard
Recent advances in the total synthesis of cyclopropane-containing natural products.
Jean-Alexandre Richard; Rebecca H Pouwer; David Y-K Chen
The chemistry of the polycyclic polyprenylated acylphloroglucinols.

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All Publications

2012: David Y-K Chen; So Won Youn
C-H activation: a complementary tool in the total synthesis of complex natural products.
Chemistry (Weinheim an der Bergstrasse, Germany) 2012;18(31):9452-74.
2012: David Y-K Chen; Rebecca H Pouwer; Jean-Alexandre Richard
Recent advances in the total synthesis of cyclopropane-containing natural products.
Chemical Society reviews 2012;41(13):4631-42.
2012: Jean-Alexandre Richard; Rebecca H Pouwer; David Y-K Chen
The chemistry of the polycyclic polyprenylated acylphloroglucinols.
Angewandte Chemie (International ed. in English) 2012;51(19):4536-61.
2011: Philippe A Peixoto; Jean-Alexandre Richard; Rene Severin; David Y-K Chen
Total synthesis of echinopines A and B: exploiting a bioinspired late-stage intramolecular cyclopropanation.
Organic letters 2011;13(21):5724-7.
2011: Chih-Chung Tseng; Hanfeng Ding; Yucui Guan; Ang Li; David Y-K Chen
A modular synthesis of salvileucalin B structural domains.
Organic letters 2011;13(16):4410-3.
2011: Michaela Wenzel; Malay Patra; Dirk Albrecht; David Y-K Chen; K C Nicolaou; Nils Metzler-Nolte; Julia E Bandow
Proteomic signature of fatty acid biosynthesis inhibition available for in vivo mechanism-of-action studies.
Antimicrobial agents and chemotherapy 2011;55(6):2590-6.
2011: Lin Dong; Lujiang Deng; Yee Hwee Lim; Gulice Y C Leung; David Y-K Chen
Synthesis of an advanced maoecrystal V core structure.
Chemistry (Weinheim an der Bergstrasse, Germany) 2011;17(21):5778-81.
2011: Hau Man Cheng; Weiwei Tian; Philippe A Peixoto; Bhartesh Dhudshia; David Y-K Chen
Synthesis of ent-nanolobatolide.
Angewandte Chemie (International ed. in English) 2011;50(18):4165-8.
2011: Philippe A Peixoto; Rene Severin; Chih-Chung Tseng; David Y-K Chen
Formal asymmetric synthesis of echinopine A and B.
Angewandte Chemie (International ed. in English) 2011;50(13):3013-6.
2011: Kok-Ping Chan; David Y-K Chen
Chemical synthesis and biological evaluation of the englerin analogues.
ChemMedChem 2011;6(3):420-3.
2011: Hanfeng Ding; David Y-K Chen
Formal syntheses of (-)- and (+)-phalarine.
Angewandte Chemie (International ed. in English) 2011;50(3):676-9.
2010: David Y-K Chen; Qiang Kang; T Robert Wu
Modular synthesis of polyphenolic benzofurans, and application in the total synthesis of malibatol a and shoreaphenol.
Molecules (Basel, Switzerland) 2010;15(9):5909-27.
2010: Kyriacos C Nicolaou; Qiang Kang; Sin Yee Ng; David Y-K Chen
Total synthesis of englerin A.
Journal of the American Chemical Society 2010;132(23):8219-22.
2010: Kyriacos C Nicolaou; Qiang Kang; T Robert Wu; Chek Shik Lim; David Y-K Chen
Total synthesis and biological evaluation of the resveratrol-derived polyphenol natural products hopeanol and hopeahainol A.
Journal of the American Chemical Society 2010;132(21):7540-8.
2010: Kyriacos C Nicolaou; Hanfeng Ding; Jean-Alexandre Richard; David Y-K Chen
Total synthesis of echinopines A and B.
Journal of the American Chemical Society 2010;132(11):3815-8.
2010: Kyriacos C Nicolaou; Lin Dong; Lujiang Deng; Adam C Talbot; David Y-K Chen
Synthesis of functionalized maoecrystal V core structures.
Chemical communications (Cambridge, England) 2010;46(1):70-2.
2009: Agata Starosta; Haiou Qin; Aleksandra Mikolajka; Gulice Y C Leung; Kathrin Schwinghammer; Kyriacos C Nicolaou; David Y-K Chen; Barry S Cooperman; Daniel N Wilson
Identification of distinct thiopeptide-antibiotic precursor lead compounds using translation machinery assays.
Chemistry & biology 2009;16(10):1087-96.
2009: Kyriacos C Nicolaou; Xiao-Shui Peng; Ya-Ping Sun; Damien Polet; Bin Zou; Chek Shik Lim; David Y-K Chen
Total synthesis and biological evaluation of cortistatins A and J and analogues thereof.
Journal of the American Chemical Society 2009;131(30):10587-97.
2009: Kyriacos C Nicolaou; Arkady Krasovskiy; Utpal Majumder; Vincent E Trépanier; David Y-K Chen
New synthetic technologies for the construction of heterocycles and tryptamines.
Journal of the American Chemical Society 2009;131(10):3690-9.
2009: Victor J Cee; David Y-K Chen; Matthew R Lee; K C Nicolaou
Cortistatin A is a high-affinity ligand of protein kinases ROCK, CDK8, and CDK11.
Angewandte Chemie (International ed. in English) 2009;48(47):8952-7.
2009: K C Nicolaou; Stephen M Dalby; Shuoliang Li; Takahiro Suzuki; David Y-K Chen
Total synthesis of (+)-haplophytine.
Angewandte Chemie (International ed. in English) 2009;48(41):7616-20.
2009: Kyriacos C Nicolaou; T Robert Wu; Qiang Kang; David Y-K Chen
Total synthesis of hopeahainol A and hopeanol.
Angewandte Chemie (International ed. in English) 2009;48(19):3440-3.
2008: Kyriacos C Nicolaou; Qiao Yan Toh; David Y-K Chen
An expedient asymmetric synthesis of platencin.
Journal of the American Chemical Society 2008;130(34):11292-3.
2008: Kyriacos C Nicolaou; Gulice Y C Leung; Dattatraya H Dethe; Ramakrishna Guduru; Ya-Ping Sun; Chek Shik Lim; David Y-K Chen
Chemical synthesis and biological evaluation of palmerolide A analogues.
Journal of the American Chemical Society 2008;130(30):10019-23.
2008: Kyriacos C Nicolaou; Dattatraya H Dethe; David Y-K Chen
Total syntheses of amythiamicins A, B and C.
Chemical communications (Cambridge, England) 2008;(23):2632-4.
2008: Kyriacos C Nicolaou; Ya-Ping Sun; Ramakrishna Guduru; Biswadip Banerji; David Y-K Chen
Total synthesis of the originally proposed and revised structures of palmerolide A and isomers thereof.
Journal of the American Chemical Society 2008;130(11):3633-44.
2008: Kyriacos C Nicolaou; Dattatraya H Dethe; Gulice Y C Leung; Bin Zou; David Y-K Chen
Total synthesis of thiopeptide antibiotics GE2270A, GE2270T, and GE2270C1.
Chemistry, an Asian journal 2008;3(2):413-29.
2008: Kyriacos C Nicolaou; Ya-Ping Sun; Xiao-Shui Peng; Damien Polet; David Y-K Chen
Total synthesis of (+)-cortistatin A.
Angewandte Chemie (International ed. in English) 2008;47(38):7310-3.
2008: Kyriacos C Nicolaou; Arkady Krasovskiy; Vincent E Trépanier; David Y-K Chen
An expedient strategy for the synthesis of tryptamines and other heterocycles.
Angewandte Chemie (International ed. in English) 2008;47(22):4217-20.
2008: Kyriacos C Nicolaou; Doron Pappo; Kit Y Tsang; Romelo Gibe; David Y-K Chen
A chiral pool based synthesis of platensimycin.
Angewandte Chemie (International ed. in English) 2008;47(5):944-6.
2007: KC Nicolaou; Ramakrishna Guduru; Ya-Ping Sun; Biswadip Banerji; David Y-K Chen
Total synthesis of the originally proposed and revised structures of palmerolide A.
Angewandte Chemie (International ed. in English) 2007;46(31):5896-900.
2007: KC Nicolaou; Utpal Majumder; Stephane Philippe Roche; David Y-K Chen
Construction of the "left domain" of haplophytine.
Angewandte Chemie (International ed. in English) 2007;46(25):4715-8.
2006: KC Nicolaou; Bin Zou; Dattatraya H Dethe; Dong Bo Li; David Y-K Chen
Total synthesis of antibiotics GE2270A and GE2270T.
Angewandte Chemie (International ed. in English) 2006;45(46):7786-92.
2006: Kyriacos C Nicolaou; Theocharis V Koftis; Stepan Vyskocil; Goran Petrovic; Wenjun Tang; Michael O Frederick; David Y-K Chen; Yiwei Li; Taotao Ling; Yoichi M A Yamada
Total synthesis and structural elucidation of azaspiracid-1. Final assignment and total synthesis of the correct structure of azaspiracid-1.
Journal of the American Chemical Society 2006;128(9):2859-72.
2006: Kyriacos C Nicolaou; David Y-K Chen; Yiwei Li; Noriaki Uesaka; Goran Petrovic; Theocharis V Koftis; Federico Bernal; Michael O Frederick; Mugesh Govindasamy; Taotao Ling; Petri M Pihko; Wenjun Tang; Stepan Vyskocil
Total synthesis and structural elucidation of azaspiracid-1. Synthesis-based analysis of originally proposed structures and indication of their non-identity to the natural product.
Journal of the American Chemical Society 2006;128(7):2258-67.
2005: Ian Paterson; David Y-K Chen; Mark J Coster; José L Aceña; Jordi Bach; Debra J Wallace
The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: fragment couplings, completion of the synthesis, analogue generation and biological evaluation.
Organic & biomolecular chemistry 2005;3(13):2431-40.
2005: Ian Paterson; Mark J Coster; David Y-K Chen; José L Aceña; Jordi Bach; Linda E Keown; Thomas Trieselmann
The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the southern hemisphere EF segment.
Organic & biomolecular chemistry 2005;3(13):2420-30.
2005: Ian Paterson; Mark J Coster; David Y-K Chen; Karl R Gibson; Debra J Wallace
The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the CD-spiroacetal segment.
Organic & biomolecular chemistry 2005;3(13):2410-9.
2005: Ian Paterson; Mark J Coster; David Y-K Chen; Renata Oballa; Debra J Wallace; Roger D Norcross
The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the AB-spiroacetal segment.
Organic & biomolecular chemistry 2005;3(13):2399-409.
2004: Kyriacos C Nicolaou; Junliang Hao; Mali V Reddy; Paraselli Bheema Rao; Gerasimos Rassias; Scott A Snyder; Xianhai Huang; David Y-K Chen; William E Brenzovich; Nicolas Giuseppone; Aurora O'Brate; Paraskevi Giannakakou
Chemistry and biology of diazonamide A: second total synthesis and biological investigations.
Journal of the American Chemical Society 2004;126(40):12897-906.
2004: Kyriacos C Nicolaou; David Y-K Chen; Xianhai Huang; Taotao Ling; Marco Bella; Scott A Snyder
Chemistry and biology of diazonamide A: first total synthesis and confirmation of the true structure.
Journal of the American Chemical Society 2004;126(40):12888-96.
2004: Kyriacos C Nicolaou; Stepan Vyskocil; Theocharis V Koftis; Yoichi M A Yamada; Taotao Ling; David Y-K Chen; Wenjun Tang; Goran Petrovic; Michael O Frederick; Yiwei Li; Masayuki Satake
Structural revision and total synthesis of azaspiracid-1, part 1: intelligence gathering and tentative proposal.
Angewandte Chemie (International ed. in English) 2004;43(33):4312-8.
2003: Kyriacos C Nicolaou; David Y-K Chen; Yiwei Li; Wenyuan Qian; Taotao Ling; Stepan Vyskocil; Theocharis V Koftis; Mugesh Govindasamy; Noriaki Uesaka
Total synthesis of the proposed azaspiracid-1 structure, part 2: coupling of the C1-C20, C21-C27, and C28-C40 fragments and completion of the synthesis.
Angewandte Chemie (International ed. in English) 2003;42(31):3649-53.
2003: Kyriacos C Nicolaou; Yiwei Li; Noriaki Uesaka; Theocharis V Koftis; Stepan Vyskocil; Taotao Ling; Mugesh Govindasamy; Wenyuan Qian; Federico Bernal; David Y-K Chen
Total synthesis of the proposed azaspiracid-1 structure, part 1: construction of the enantiomerically pure C1-C20, C21-C27, and C28-C40 fragments.
Angewandte Chemie (International ed. in English) 2003;42(31):3643-8.
2003: Kyriacos C Nicolaou; Paraselli Bheema Rao; Junliang Hao; Mali V Reddy; Gerasimos Rassias; Xianhai Huang; David Y-K Chen; Scott A Snyder
The second total synthesis of diazonamide A.
Angewandte Chemie (International ed. in English) 2003;42(15):1753-8.
2003: Ian Paterson; José L Aceña; Jordi Bach; David Y-K Chen; Mark J Coster
Synthesis and biological evaluation of spongistatin/altohyrtin analogues: E-ring dehydration and C46 side-chain truncation.
Chemical communications (Cambridge, England) 2003;(4):462-3.
2002: Kyriacos C Nicolaou; Marco Bella; David Y-K Chen; Xianhai Huang; Taotao Ling; Scott A Snyder
Total synthesis of diazonamide A.
Angewandte Chemie (International ed. in English) 2002;41(18):3495-9.