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Fusheng Chen

Research Profile

Chemicals & Drugs

Anatomy

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Mouse

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Alzheimer's Disease

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Physiology

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Amino Acid Sequences

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Raphaëlle Pardossi-Piquard; Christopher Böhm; Fusheng Chen; Soshi Kanemoto; Frédéric Checler; Gerold Schmitt-Ulms; Peter St George-Hyslop; Paul E Fraser
TMP21 transmembrane domain regulates gamma-secretase cleavage.
Raphaëlle Pardossi-Piquard; Seung-Pil Yang; Soshi Kanemoto; Yongjun Gu; Fusheng Chen; Christopher Böhm; Jean Sevalle; Tong Li; Philip C Wong; Frédéric Checler; Gerold Schmitt-Ulms; Peter St George-Hyslop; Paul E Fraser
APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexes.
Yu Bai; Kelly Markham; Fusheng Chen; Rasanjala Weerasekera; Joel Watts; Patrick Horne; Yosuke Wakutani; Richard D Bagshaw; Paul Mathews; Paul E Fraser; David Westaway; Peter St George-Hyslop; Gerold Schmitt-Ulms
The in vivo brain interactome of the amyloid precursor protein.

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All Publications

2009: Raphaëlle Pardossi-Piquard; Christopher Böhm; Fusheng Chen; Soshi Kanemoto; Frédéric Checler; Gerold Schmitt-Ulms; Peter St George-Hyslop; Paul E Fraser
TMP21 transmembrane domain regulates gamma-secretase cleavage.
The Journal of biological chemistry 2009;284(42):28634-41.
2009: Raphaëlle Pardossi-Piquard; Seung-Pil Yang; Soshi Kanemoto; Yongjun Gu; Fusheng Chen; Christopher Böhm; Jean Sevalle; Tong Li; Philip C Wong; Frédéric Checler; Gerold Schmitt-Ulms; Peter St George-Hyslop; Paul E Fraser
APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexes.
The Journal of biological chemistry 2009;284(24):16298-307.
2008: Yu Bai; Kelly Markham; Fusheng Chen; Rasanjala Weerasekera; Joel Watts; Patrick Horne; Yosuke Wakutani; Richard D Bagshaw; Paul Mathews; Paul E Fraser; David Westaway; Peter St George-Hyslop; Gerold Schmitt-Ulms
The in vivo brain interactome of the amyloid precursor protein.
Molecular & cellular proteomics : MCP 2008;7(1):15-34.
2007: Raphaëlle Pardossi-Piquard; Fusheng Chen; Nancy F Silva-Gagliardi; Michael Szego; Roderick McInnes; C Jane McGlade; Peter St George-Hyslop; Paul E Fraser
Overexpression of human CRB1 or related isoforms, CRB2 and CRB3, does not regulate the human presenilin complex in culture cells.
Biochemistry 2007;46(48):13704-10.
2006: JoAnne McLaurin; Meredith E Kierstead; Mary E Brown; Cheryl A Hawkes; Mark H L Lambermon; Amie L Phinney; Audrey A Darabie; Julian E Cousins; John French; Melissa F Lan; Fusheng Chen; Sydney S N Wong; Howard T J Mount; Paul E Fraser; David Westaway; Peter St George-Hyslop
Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model.
Nature medicine 2006;12(7):801-8.
2006: Fusheng Chen; Hiroshi Hasegawa; Gerold Schmitt-Ulms; Toshitaka Kawarai; Christopher Bohm; Taiichi Katayama; Yongjun Gu; Nobuo Sanjo; Michael Glista; Ekaterina Rogaeva; Yosuke Wakutani; Raphaëlle Pardossi-Piquard; Xueying Ruan; Anurag Tandon; Frédéric Checler; Philippe Marambaud; Kirk Hansen; David Westaway; Peter St George-Hyslop; Paul E Fraser
TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.
Nature 2006;440(7088):1208-12.
2005: Agnes Petit; Toshitaka Kawarai; Erwan Paitel; Nobuo Sanjo; Mary Maj; Michael Scheid; Fusheng Chen; Yongjun Gu; Hiroshi Hasegawa; Shabnam Salehi-Rad; Linda Wang; Ekaterina Rogaeva; Paul E Fraser; Brian Robinson; Peter St George-Hyslop; Anurag Tandon
Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations.
The Journal of biological chemistry 2005;280(40):34025-32.
2004: Hiroshi Hasegawa; Nobuo Sanjo; Fusheng Chen; Yong-Jun Gu; Cortney Shier; Agnes Petit; Toshitaka Kawarai; Taiichi Katayama; Stephen D Schmidt; Paul Mathews; Gerold Schmitt-Ulms; Paul E Fraser; Peter St George-Hyslop
Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes.
The Journal of biological chemistry 2004;279(45):46455-63.
2004: Yongjun Gu; Nobuo Sanjo; Fusheng Chen; Hiroshi Hasegawa; Agnes Petit; Xueying Ruan; Wenping Li; Cortney Shier; Toshitaka Kawarai; Gerold Schmitt-Ulms; David Westaway; Peter St George-Hyslop; Paul E Fraser
The presenilin proteins are components of multiple membrane-bound complexes that have different biological activities.
The Journal of biological chemistry 2004;279(30):31329-36.
2003: Anurag Tandon; Haung Yu; Linda Wang; Ekaterina Rogaeva; Christine Sato; M Azhar Chishti; Toshitaka Kawarai; Hiroshi Hasegawa; Fusheng Chen; Peter Davies; Paul E Fraser; David Westaway; Peter St George-Hyslop
Brain levels of CDK5 activator p25 are not increased in Alzheimer's or other neurodegenerative diseases with neurofibrillary tangles.
Journal of neurochemistry 2003;86(3):572-81.
2003: Fusheng Chen; Anurag Tandon; Nobuo Sanjo; Yong-Jun Gu; Hiroshi Hasegawa; Shigeki Arawaka; Frank J S Lee; Xueying Ruan; Peter Mastrangelo; Serap Erdebil; Linda Wang; David Westaway; Howard T J Mount; Bruce A Yankner; Paul E Fraser; Peter St George-Hyslop
Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain.
The Journal of biological chemistry 2003;278(22):19974-9.
2003: Yongjun Gu; Fusheng Chen; Nobuo Sanjo; Toshitaka Kawarai; Hiroshi Hasegawa; Monika Duthie; Wenping Li; Xueying Ruan; Anchla Luthra; Howard T J Mount; Anurag Tandon; Paul E Fraser; Peter St George-Hyslop
APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes.
The Journal of biological chemistry 2003;278(9):7374-80.
2002: Shigeki Arawaka; Hiroshi Hasegawa; Anurag Tandon; Christopher Janus; Fusheng Chen; Gang G. Yu; Kenji Kikuchi; Shingo Koyama; Takeo Kato; Paul E Fraser; Peter St George-Hyslop
The levels of mature glycosylated nicastrin are regulated and correlate with gamma-secretase processing of amyloid beta-precursor protein.
Journal of neurochemistry 2002;83(5):1065-71.
2002: Richard Rozmahel; Howard T J Mount; Fusheng Chen; Van Nguyen; Jean Huang; Serap Erdebil; Jennifer Liauw; Gang G. Yu; Hiroshe Hasegawa; YongJun Gu; You-Qiang Song; Stephen D Schmidt; Ralph A. Nixon; Paul Mathews; Catherine Bergeron; Paul E Fraser; David Westaway; Peter St George-Hyslop
Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14452-7.
2002: Fusheng Chen; YongJun Gu; Hiroshi Hasegawa; Xueying Ruan; Shigeki Arawaka; Paul E Fraser; David Westaway; Howard T J Mount; Peter St George-Hyslop
Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch.
The Journal of biological chemistry 2002;277(39):36521-6.
2002: Dun-Sheng Yang; Anurag Tandon; Fusheng Chen; Gang G. Yu; Haung Yu; Shigeki Arawaka; Hiroshi Hasegawa; Monika Duthie; Stephen D Schmidt; Triprayer V Ramabhadran; Ralph A. Nixon; Paul Mathews; Sam Gandy; Howard T J Mount; Peter St George-Hyslop; Paul E Fraser
Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins.
The Journal of biological chemistry 2002;277(31):28135-42.
2002: Richard Rozmahel; Jean Huang; Fusheng Chen; Yan Liang; Van Nguyen; Masaki Ikeda; Georges Levesque; Gang G. Yu; M Nishimura; Paul Mathews; Stephen D Schmidt; Marc Mercken; Catherine Bergeron; David Westaway; Peter St George-Hyslop
Normal brain development in PS1 hypomorphic mice with markedly reduced gamma-secretase cleavage of betaAPP.
Neurobiology of aging 2002;23(2):187-94.
2001: Fusheng Chen; Gang G. Yu; Shigeki Arawaka; M Nishimura; Toshitaka Kawarai; Haung Yu; Anurag Tandon; Agnes Supala; You-Qiang Song; Ekaterina Rogaeva; P Milman; Christine Sato; C Yu; Christopher Janus; J Lee; L Song; Liyong Zhang; Paul E Fraser; Peter St George-Hyslop
Nicastrin binds to membrane-tethered Notch.
Nature cell biology 2001;3(8):751-4.
2000: Fusheng Chen; Dun-Sheng Yang; Suzana Petanceska; Austin Yang; Anurag Tandon; Gang G. Yu; Richard Rozmahel; Jorge Ghiso; M Nishimura; DM Zhang; Toshitaka Kawarai; Georges Levesque; J Mills; L Levesque; You-Qiang Song; Ekaterina Rogaeva; David Westaway; Howard T J Mount; Sam Gandy; Peter St George-Hyslop; Paul E Fraser
Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.
The Journal of biological chemistry 2000;275(47):36794-802.
2000: DM Zhang; D Levitan; Gang G. Yu; M Nishimura; Fusheng Chen; Anurag Tandon; Toshitaka Kawarai; Shigeki Arawaka; Agnes Supala; You-Qiang Song; Ekaterina Rogaeva; Yan Liang; E Holmes; P Milman; Christine Sato; Liyong Zhang; Peter St George-Hyslop
Mutation of the conserved N-terminal cysteine (Cys92) of human presenilin 1 causes increased A beta42 secretion in mammalian cells but impaired Notch/lin-12 signalling in C. elegans.
Neuroreport 2000;11(14):3227-30.
2000: Gang G. Yu; M Nishimura; Shigeki Arawaka; D Levitan; Liyong Zhang; Anurag Tandon; You-Qiang Song; Ekaterina Rogaeva; Fusheng Chen; Toshitaka Kawarai; Agnes Supala; L Levesque; Haung Yu; Dun-Sheng Yang; E Holmes; P Milman; Yan Liang; DM Zhang; D H Xu; Christine Sato; Evgeny I Rogaev; M Smith; Christopher Janus; Y Zhang; R Aebersold; Lindsay A Farrer; Sandro Sorbi; Amalia C Bruni; Paul E Fraser; Peter St George-Hyslop
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing.
Nature 2000;407(6800):48-54.
2000: Gang G. Yu; Fusheng Chen; M Nishimura; H Steiner; Anurag Tandon; Toshitaka Kawarai; Shigeki Arawaka; Agnes Supala; You-Qiang Song; Ekaterina Rogaeva; E Holmes; DM Zhang; P Milman; Paul E Fraser; Christian Haass; Peter St George-Hyslop
Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes.
The Journal of biological chemistry 2000;275(35):27348-53.
2000: Gang G. Yu; Fusheng Chen; M Nishimura; H Steiner; Anurag Tandon; Toshitaka Kawarai; Shigeki Arawaka; Agnes Supala; You-Qiang Song; Ekaterina Rogaeva; E Holmes; DM Zhang; P Milman; Paul E Fraser; Christian Haass; Peter St George-Hyslop
Mutation of conserved aspartates affect maturation of presenilin 1 and presenilin 2 complexes.
Acta neurologica Scandinavica. Supplementum 2000;176():6-11.
1999: M Nishimura; Gang G. Yu; Georges Levesque; DM Zhang; L Ruel; Fusheng Chen; P Milman; E Holmes; Yan Liang; Toshitaka Kawarai; E Jo; Agnes Supala; Ekaterina Rogaeva; D M Xu; Christopher Janus; L Levesque; Q Bi; Monika Duthie; Richard Rozmahel; K Mattila; Lars Lannfelt; David Westaway; Howard T J Mount; James R Woodgett; Peter St George-Hyslop
Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex.
Nature medicine 1999;5(2):164-9.
1998: Gang G. Yu; Fusheng Chen; Georges Levesque; M Nishimura; DM Zhang; L Levesque; Ekaterina Rogaeva; D Xu; Yan Liang; Monika Duthie; Peter St George-Hyslop; Paul E Fraser
The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin.
The Journal of biological chemistry 1998;273(26):16470-5.