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Huixiong Chen

Research Profile

Chemicals & Drugs

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Drug Design

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Publications

TOP 3
Fanny Jardinaud; Ghazal Banisadr; Florence Noble; Stéphane Mélik Parsadaniantz; Huixiong Chen; Christophe Dugave; Hervé Laplace; William Rostène; Marie-Claude Fournié-Zaluski; Bernard P Roques; Théodora Popovici
Ontogenic and adult whole body distribution of aminopeptidase N in rat investigated by in vitro autoradiography.
Stéphanie Le Guen; Magdalena Mas Nieto; Corinne Canestrelli; Huixiong Chen; Marie-Claude Fournié-Zaluski; Annie Cupo; Rafael Maldonado; Bernard P Roques; Florence Noble
Pain management by a new series of dual inhibitors of enkephalin degrading enzymes: long lasting antinociceptive properties and potentiation by CCK2 antagonist or methadone.
Huixiong Chen; Florence Noble; Bernard P Roques; Marie-Claude Fournié-Zaluski
Long lasting antinociceptive properties of enkephalin degrading enzyme (NEP and APN) inhibitor prodrugs.

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All Publications

2004: Fanny Jardinaud; Ghazal Banisadr; Florence Noble; Stéphane Mélik Parsadaniantz; Huixiong Chen; Christophe Dugave; Hervé Laplace; William Rostène; Marie-Claude Fournié-Zaluski; Bernard P Roques; Théodora Popovici
Ontogenic and adult whole body distribution of aminopeptidase N in rat investigated by in vitro autoradiography.
Biochimie 2004;86(2):105-13.
2003: Stéphanie Le Guen; Magdalena Mas Nieto; Corinne Canestrelli; Huixiong Chen; Marie-Claude Fournié-Zaluski; Annie Cupo; Rafael Maldonado; Bernard P Roques; Florence Noble
Pain management by a new series of dual inhibitors of enkephalin degrading enzymes: long lasting antinociceptive properties and potentiation by CCK2 antagonist or methadone.
Pain 2003;104(1-2):139-48.
2001: Huixiong Chen; Florence Noble; Bernard P Roques; Marie-Claude Fournié-Zaluski
Long lasting antinociceptive properties of enkephalin degrading enzyme (NEP and APN) inhibitor prodrugs.
Journal of medicinal chemistry 2001;44(21):3523-30.
2001: Florence Noble; Ghazal Banisadr; Fanny Jardinaud; T Popovici; R Lai-Kuen; Huixiong Chen; L Bischoff; Stéphane Mélik Parsadaniantz; MC Fournie-Zaluski; Bernard P Roques
First discrete autoradiographic distribution of aminopeptidase N in various structures of rat brain and spinal cord using the selective iodinated inhibitor [125I]RB 129.
Neuroscience 2001;105(2):479-88.
2000: Huixiong Chen; Florence Noble; A Mothé; Hervé MEUDAL; Pascale Coric; S Danascimento; Bernard P Roques; Pascal Guy GEORGE; Marie-Claude Fournié-Zaluski
Phosphinic derivatives as new dual enkephalin-degrading enzyme inhibitors: synthesis, biological properties, and antinociceptive activities.
Journal of medicinal chemistry 2000;43(7):1398-408.
2000: Florence Noble; N Luciani; Sophie Da Nascimento; R Laï-Kuen; L Bischoff; Huixiong Chen; Marie-Claude Fournié-Zaluski; Bernard P Roques
Binding properties of a highly potent and selective iodinated aminopeptidase N inhibitor appropriate for radioautography.
FEBS letters 2000;467(1):81-6.
1999: Huixiong Chen; Bernard P Roques; Marie-Claude Fournié-Zaluski
Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor.
Bioorganic & medicinal chemistry letters 1999;9(11):1511-6.
1998: Huixiong Chen; Florence Noble; Pascale Coric; MC Fournie-Zaluski; Bernard P Roques
Aminophosphinic inhibitors as transition state analogues of enkephalin-degrading enzymes: a class of central analgesics.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):12028-33.