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Hua Chen

Research Profile

Chemicals & Drugs

Living Beings

Anatomy

Tumor Cell Line

Procedures

Disorders

Glioblastoma

Physiology

Cell Death

Devices

Drug Delivery Systems

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Publications

TOP 3
Alexander K Tsai; Seunguk Oh; Hua Chen; Yanqun Shu; John R Ohlfest; Daniel A Vallera
A novel bispecific ligand-directed toxin designed to simultaneously target EGFR on human glioblastoma cells and uPAR on tumor neovasculature.
Daniel A Vallera; Seunguk Oh; Hua Chen; Yanqun Shu; Arthur E Frankel
Bioengineering a unique deimmunized bispecific targeted toxin that simultaneously recognizes human CD22 and CD19 receptors in a mouse model of B-cell metastases.
Seunguk Oh; John R Ohlfest; Deborah A Todhunter; Vincent D Vallera; Walter A Hall; Hua Chen; Daniel A Vallera
Intracranial elimination of human glioblastoma brain tumors in nude rats using the bispecific ligand-directed toxin, DTEGF13 and convection enhanced delivery.

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All Publications

2011: Alexander K Tsai; Seunguk Oh; Hua Chen; Yanqun Shu; John R Ohlfest; Daniel A Vallera
A novel bispecific ligand-directed toxin designed to simultaneously target EGFR on human glioblastoma cells and uPAR on tumor neovasculature.
Journal of neuro-oncology 2011;103(2):255-66.
2010: Daniel A Vallera; Seunguk Oh; Hua Chen; Yanqun Shu; Arthur E Frankel
Bioengineering a unique deimmunized bispecific targeted toxin that simultaneously recognizes human CD22 and CD19 receptors in a mouse model of B-cell metastases.
Molecular cancer therapeutics 2010;9(6):1872-83.
2009: Seunguk Oh; John R Ohlfest; Deborah A Todhunter; Vincent D Vallera; Walter A Hall; Hua Chen; Daniel A Vallera
Intracranial elimination of human glioblastoma brain tumors in nude rats using the bispecific ligand-directed toxin, DTEGF13 and convection enhanced delivery.
Journal of neuro-oncology 2009;95(3):331-42.
2009: Seunguk Oh; Brad J Stish; Deepali Sachdev; Hua Chen; Arkadiusz Z Dudek; Daniel A Vallera
A novel reduced immunogenicity bispecific targeted toxin simultaneously recognizing human epidermal growth factor and interleukin-4 receptors in a mouse model of metastatic breast carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(19):6137-47.
2009: Daniel A Vallera; Hua Chen; Andy Sicheneder; Angela Panoskaltsis-Mortari; Elizabeth P Taras
Genetic alteration of a bispecific ligand-directed toxin targeting human CD19 and CD22 receptors resulting in improved efficacy against systemic B cell malignancy.
Leukemia research 2009;33(9):1233-42.
2007: Brad J Stish; Hua Chen; Yanqun Shu; Angela Panoskaltsis-Mortari; Daniel A Vallera
A bispecific recombinant cytotoxin (DTEGF13) targeting human interleukin-13 and epidermal growth factor receptors in a mouse xenograft model of prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(21):6486-93.
2007: Brad J Stish; Hua Chen; Yanqun Shu; Angela Panoskaltsis-Mortari; Daniel A Vallera
Increasing anticarcinoma activity of an anti-erbB2 recombinant immunotoxin by the addition of an anti-EpCAM sFv.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(10):3058-67.
2005: Daniel A Vallera; Deborah A Todhunter; David W Kuroki; Yanqun Shu; Andy Sicheneder; Hua Chen
A bispecific recombinant immunotoxin, DT2219, targeting human CD19 and CD22 receptors in a mouse xenograft model of B-cell leukemia/lymphoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(10):3879-88.
2005: Daniel A Vallera; Deborah A Todhunter; David W Kuroki; Yanqun Shu; Andy Sicheneder; Angela Panoskaltsis-Mortari; Vincent D Vallera; Hua Chen
Molecular modification of a recombinant, bivalent anti-human CD3 immunotoxin (Bic3) results in reduced in vivo toxicity in mice.
Leukemia research 2005;29(3):331-41.

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