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Irvin Chen

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Min Liang; Yunfeng Lu; Ming Yan; Irvin S Y Chen
Retargeting vesicular stomatitis virus glycoprotein pseudotyped lentiviral vectors with enhanced stability by in situ synthesized polymer shell.
Ming Yan; Min Liang; Yang Liu; Yunfeng Lu; Jing Wen; Irvin S Y Chen
Single siRNA nanocapsules for enhanced RNAi delivery.
Gene-Errol Ringpis; Anna Sahakyan; Saki Shimizu; Geoff Symonds; Yiming Xie; Fadi N Kandarian; Patrick Y Kim; Emily L Lowe; Munetoshi Narukawa; Dong Sung An; Hubert Arokium; Bryan P Burke; Joanna Camba-Colón; Maria V Carroll; Irvin S Y Chen; Ruth Cortado; Masakazu Kamata
Engineering HIV-1-resistant T-cells from short-hairpin RNA-expressing hematopoietic stem/progenitor cells in humanized BLT mice.

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All Publications

2013: Min Liang; Yunfeng Lu; Ming Yan; Irvin S Y Chen
Retargeting vesicular stomatitis virus glycoprotein pseudotyped lentiviral vectors with enhanced stability by in situ synthesized polymer shell.
Human gene therapy methods 2013;24(1):11-8.
2012: Ming Yan; Min Liang; Yang Liu; Yunfeng Lu; Jing Wen; Irvin S Y Chen
Single siRNA nanocapsules for enhanced RNAi delivery.
Journal of the American Chemical Society 2012;134(33):13542-5.
2012: Gene-Errol Ringpis; Anna Sahakyan; Saki Shimizu; Geoff Symonds; Yiming Xie; Fadi N Kandarian; Patrick Y Kim; Emily L Lowe; Munetoshi Narukawa; Dong Sung An; Hubert Arokium; Bryan P Burke; Joanna Camba-Colón; Maria V Carroll; Irvin S Y Chen; Ruth Cortado; Masakazu Kamata
Engineering HIV-1-resistant T-cells from short-hairpin RNA-expressing hematopoietic stem/progenitor cells in humanized BLT mice.
PloS one 2012;7(12):e53492.
2011: Kouki Morizono; Irvin S Y Chen
Receptors and tropisms of envelope viruses.
Current opinion in virology 2011;1(1):13-8.
2011: Kouki Morizono; Yiming Xie; Tove Olafsen; Benhur Lee; Asim Dasgupta; Anna M Wu; Irvin S Y Chen
The soluble serum protein Gas6 bridges virion envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry.
Cell host & microbe 2011;9(4):286-98.
2011: Kai-Xin Zhang; Connie Kim; Elaine Chow; Irvin S Y Chen; William Jia; Paul S Rennie
Targeting trastuzumab-resistant breast cancer cells with a lentivirus engineered to bind antibodies that recognize HER-2.
Breast cancer research and treatment 2011;125(1):89-97.
2010: Irvin S Y Chen
Introduction. The UCLA AIDS Institute.
Immunologic research 2010;48(1-3):1-2.
2010: Sanggu Kim; Namshin Kim; Angela P Presson; Dong Sung An; Si-Hua Mao; Aylin Bonifacino; Robert E Donahue; Samson A Chow; Irvin S Y Chen
High-throughput, sensitive quantification of repopulating hematopoietic stem cell clones.
Journal of virology 2010;84(22):11771-80.
2010: Masakazu Kamata; Shirley Liu; Min Liang; Yoshiko Nagaoka; Irvin S Y Chen
Generation of human induced pluripotent stem cells bearing an anti-HIV transgene by a lentiviral vector carrying an internal murine leukemia virus promoter.
Human gene therapy 2010;21(11):1555-67.
2010: Kouki Morizono; Amy Ku; Yiming Xie; Airi Harui; Sam K P Kung; Michael D Roth; Benhur Lee; Irvin S Y Chen
Redirecting lentiviral vectors pseudotyped with Sindbis virus-derived envelope proteins to DC-SIGN by modification of N-linked glycans of envelope proteins.
Journal of virology 2010;84(14):6923-34.
2010: Min Liang; masakazu kamata; Kevin N Chen; Nonia Pariente; Dong Sung An; Irvin S Y Chen
Inhibition of HIV-1 infection by a unique short hairpin RNA to chemokine receptor 5 delivered into macrophages through hematopoietic progenitor cell transduction.
The journal of gene medicine 2010;12(3):255-65.
2010: Saki Shimizu; Patrick Hong; Balamurugan Arumugam; Lauren Pokomo; Joshua Boyer; Naoya Koizumi; Panyamol Kittipongdaja; Angela Chen; Greg Bristol; Zoran Galic; Jerome A Zack; Otto Yang; Irvin S Y Chen; Benhur Lee; Dong Sung An
A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model.
Blood 2010;115(8):1534-44.
2010: Masakazu Kamata; Min Liang; Shirley Liu; Yoshiko Nagaoka; Irvin S Y Chen
Live cell monitoring of hiPSC generation and differentiation using differential expression of endogenous microRNAs.
PloS one 2010;5(7):e11834.
2009: Min Liang; Kouki Morizono; Nonia Pariente; masakazu kamata; Benhur Lee; Irvin S Y Chen
Targeted transduction via CD4 by a lentiviral vector uses a clathrin-mediated entry pathway.
Journal of virology 2009;83(24):13026-31.
2009: Kouki Morizono; Yiming Xie; Gustavo Helguera; Tracy R Daniels; Timothy F Lane; Manuel L Penichet; Irvin S Y Chen
A versatile targeting system with lentiviral vectors bearing the biotin-adaptor peptide.
The journal of gene medicine 2009;11(8):655-63.
2009: Kouki Morizono; Nonia Pariente; Yiming Xie; Irvin S Y Chen
Redirecting lentiviral vectors by insertion of integrin-tageting peptides into envelope proteins.
The journal of gene medicine 2009;11(7):549-58.
2009: Qiuwei Wang; Jun-Ying Zheng; Jens Kreth; Xinmin Yan; masakazu kamata; Richard A Campbell; Yiming Xie; Robert Chiu; James R Berenson; Wenyuan Shi; Irvin S Y Chen; Shen Pang
Regulation of prostate-specific antigen expression by the junctional adhesion molecule A.
Urology 2009;73(5):1119-25.
2009: masakazu kamata; Yoshiko Nagaoka; Irvin S Y Chen
Reassessing the role of APOBEC3G in human immunodeficiency virus type 1 infection of quiescent CD4+ T-cells.
PLoS pathogens 2009;5(3):e1000342.
2009: Min Liang; Nonia Pariente; Kouki Morizono; Irvin S Y Chen
Targeted transduction of CD34+ hematopoietic progenitor cells in nonpurified human mobilized peripheral blood mononuclear cells.
The journal of gene medicine 2009;11(3):185-96.
2009: masakazu kamata; Melisa T Susanto; Irvin S Y Chen
Enhanced transthyretin tetramer stability following expression of an amyloid disease transsuppressor variant in mammalian cells.
The journal of gene medicine 2009;11(2):103-11.
2008: masakazu kamata; Nobumoto Watanabe; Yoshiko Nagaoka; Irvin S Y Chen
Human immunodeficiency virus type 1 Vpr binds to the N lobe of the Wee1 kinase domain and enhances kinase activity for CDC2.
Journal of virology 2008;82(12):5672-82.
2008: Nonia Pariente; Si-Hua Mao; Kouki Morizono; Irvin S Y Chen
Efficient targeted transduction of primary human endothelial cells with dual-targeted lentiviral vectors.
The journal of gene medicine 2008;10(3):242-8.
2007: Nonia Pariente; Kouki Morizono; Mandeep S Virk; Frank A Petrigliano; Robert E Reiter; Jay R Lieberman; Irvin S Y Chen
A novel dual-targeted lentiviral vector leads to specific transduction of prostate cancer bone metastases in vivo after systemic administration.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(11):1973-81.
2007: Betty Poon; Michael A Chang; Irvin S Y Chen
Vpr is required for efficient Nef expression from unintegrated human immunodeficiency virus type 1 DNA.
Journal of virology 2007;81(19):10515-23.
2007: Dong Sung An; Robert E Donahue; masakazu kamata; Betty Poon; Mark Metzger; Si-Hua Mao; Aylin Bonifacino; Allen Krouse; Jean-Luc Darlix; David Baltimore; F Xiao-Feng Qin; Irvin S Y Chen
Stable reduction of CCR5 by RNAi through hematopoietic stem cell transplant in non-human primates.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(32):13110-5.
2007: Qiuwei Wang; Wei Wang; Junying Zheng; Sina Tabibian; Yiming Xie; Jun Song; Alan J Waring; Robert Chiu; Otto O Yang; Irvin S Y Chen; Robert I Lehrer; Shen Pang
Paradoxical effects of two theta-defensins on HIV type 1 infection.
AIDS research and human retroviruses 2007;23(4):508-14.
2007: Dong Sung An; Betty Poon; Raphaël Ho Tsong Fang; Kees Weijer; Bianca Blom; Hergen Spits; Irvin S Y Chen; Christel H Uittenbogaart
Use of a novel chimeric mouse model with a functionally active human immune system to study human immunodeficiency virus type 1 infection.
Clinical and vaccine immunology : CVI 2007;14(4):391-6.
2007: Wellington K Hsu; Osamu Sugiyama; S H Park; Augustine H Conduah; Brian T Feeley; Nancy Q Liu; Lucie Krenek; Mandeep S Virk; Dong Sung An; Irvin S Y Chen; Jay R Lieberman
Lentiviral-mediated BMP-2 gene transfer enhances healing of segmental femoral defects in rats.
Bone 2007;40(4):931-8.
2006: Kouki Morizono; Gene-Errol Ringpis; Nonia Pariente; Yiming Xie; Irvin S Y Chen
Transient low pH treatment enhances infection of lentiviral vector pseudotypes with a targeting Sindbis envelope.
Virology 2006;355(1):71-81.
2006: Junying Zheng; Yiming Xie; Richard Campbell; Jun Song; Rose Q Wang; Robert Chiu; James Berenson; Miriam Razi; Samira Massachi; Otto O Yang; Irvin S Y Chen; Shen Pang
gp120-independent HIV infection of cells derived from the female reproductive tract, brain, and colon.
Journal of acquired immune deficiency syndromes (1999) 2006;43(2):127-36.
2006: Dong Sung An; F Xiao-Feng Qin; Vincent C Auyeung; Si-Hua Mao; Sam K P Kung; David Baltimore; Irvin S Y Chen
Optimization and functional effects of stable short hairpin RNA expression in primary human lymphocytes via lentiviral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;14(4):494-504.
2006: masakazu kamata; Raymond P Wu; Dong Sung An; Jonathan P Saxe; Robert Damoiseaux; Michael E Phelps; Jing Huang; Irvin S Y Chen
Cell-based chemical genetic screen identifies damnacanthal as an inhibitor of HIV-1 Vpr induced cell death.
Biochemical and biophysical research communications 2006;348(3):1101-6.
2006: Brian T Feeley; Augustine H Conduah; Osamu Sugiyama; Lucie Krenek; Irvin S Y Chen; Jay R Lieberman
In vivo molecular imaging of adenoviral versus lentiviral gene therapy in two bone formation models.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2006;24(8):1709-21.
2006: William E Sander; Mark E Metzger; Kouki Morizono; Aylin Bonifacino; Scott R Penzak; Yi-Ming Xie; Irvin S Y Chen; Jeffrey Bacon; Stephen G Sestrich; Lawrence P Szajek; Robert E Donahue
Noninvasive molecular imaging to detect transgene expression of lentiviral vector in nonhuman primates.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2006;47(7):1212-9.
2005: David G Brooks; Michael D Cohen; Beth D Jamieson; Betty Poon; Scott Kitchen; Samson A Chow; Irvin S Y Chen; Jerome A Zack; Prasad S Koka
Rapid size dependent deletion of foreign gene sequences inserted into attenuated HIV-1 upon infection in vivo: implications for vaccine development.
Current HIV research 2005;3(4):377-92.
2005: Betty Poon; JF Hsu; V Gudeman; Irvin S Y Chen; Kathie Grovit-Ferbas
Formaldehyde-treated, heat-inactivated virions with increased human immunodeficiency virus type 1 env can be used to induce high-titer neutralizing antibody responses.
Journal of virology 2005;79(16):10210-7.
2005: Huidong Yuan; Fenghua Fu; Jiaying Zhuo; Wei Wang; Junko Nishitani; Dong Sung An; Irvin S Y Chen; Xuan Liu
Human papillomavirus type 16 E6 and E7 oncoproteins upregulate c-IAP2 gene expression and confer resistance to apoptosis.
Oncogene 2005;24(32):5069-78.
2005: Kouki Morizono; Irvin S Y Chen
Targeted gene delivery by intravenous injection of retroviral vectors.
Cell cycle (Georgetown, Tex.) 2005;4(7):854-6.
2005: Sam K P Kung; Aylin Bonifacino; Mark E Metzger; Gene-Errol Ringpis; Robert E Donahue; Irvin S Y Chen
Lentiviral vector-transduced dendritic cells induce specific T cell response in a nonhuman primate model.
Human gene therapy 2005;16(4):527-32.
2005: Betty Poon; Jeffrey T Safrit; Harold M McClure; Christina Kitchen; JF Hsu; V Gudeman; Christos J Petropoulos; Terri Wrin; Irvin S Y Chen; Kathie Grovit-Ferbas
Induction of humoral immune responses following vaccination with envelope-containing, formaldehyde-treated, thermally inactivated human immunodeficiency virus type 1.
Journal of virology 2005;79(8):4927-35.
2005: Osamu Sugiyama; Dong Sung An; Sam P K Kung; Brian T Feeley; Seth C Gamradt; Nancy Q Liu; Irvin S Y Chen; Jay R Lieberman
Lentivirus-mediated gene transfer induces long-term transgene expression of BMP-2 in vitro and new bone formation in vivo.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;11(3):390-8.
2005: Kouki Morizono; Yiming Xie; Gene-Errol Ringpis; Mai Johnson; Hoorig Nassanian; Benhur Lee; Lily Wu; Irvin S Y Chen
Lentiviral vector retargeting to P-glycoprotein on metastatic melanoma through intravenous injection.
Nature medicine 2005;11(3):346-52.
2005: Junying Zheng; Yiming Xie; Richard Campbell; Jun Song; Samira Massachi; Miriam Razi; Robert Chiu; James Berenson; Otto O Yang; Irvin S Y Chen; Shen Pang
Involvement of claudin-7 in HIV infection of CD4(-) cells.
Retrovirology 2005;2():79.
2004: Jun Zheng; Otto O Yang; Yiming Xie; Richard Campbell; Irvin S Y Chen; Shen Pang
Ethanol stimulation of HIV infection of oral epithelial cells.
Journal of acquired immune deficiency syndromes (1999) 2004;37(4):1445-53.
2004: Robert E Donahue; Irvin S Y Chen
Transgene-specific tolerance versus immune response.
Blood 2004;104(5):1578-9; author reply 1579.
2004: Huidong Yuan; masakazu kamata; Yi-Ming Xie; Irvin S Y Chen
Increased levels of Wee-1 kinase in G(2) are necessary for Vpr- and gamma irradiation-induced G(2) arrest.
Journal of virology 2004;78(15):8183-90.
2004: Eric Ka-Wai Hui; Ee Ming Yap; Dong Sung An; Irvin S Y Chen; Debi P Nayak
Inhibition of influenza virus matrix (M1) protein expression and virus replication by U6 promoter-driven and lentivirus-mediated delivery of siRNA.
The Journal of general virology 2004;85(Pt 7):1877-84.
2003: Sam K P Kung; Dong Sung An; Aylin Bonifacino; Mark E Metzger; Gene-Errol Ringpis; Si-Hua Mao; Irvin S Y Chen; Robert E Donahue
Induction of transgene-specific immunological tolerance in myeloablated nonhuman primates using lentivirally transduced CD34+ progenitor cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;8(6):981-91.
2003: Dong Sung An; Yiming Xie; Si-Hua Mao; Kouki Morizono; Sam K P Kung; Irvin S Y Chen
Efficient lentiviral vectors for short hairpin RNA delivery into human cells.
Human gene therapy 2003;14(12):1207-12.
2003: Sheila A Stewart; Derek M. Dykxhoorn; Deborah Palliser; Hana Mizuno; Evan Y Yu; Dong Sung An; David M Sabatini; Irvin S Y Chen; William C Hahn; Phillip A Sharp; Robert A. Weinberg; Carl D Novina
Lentivirus-delivered stable gene silencing by RNAi in primary cells.
RNA (New York, N.Y.) 2003;9(4):493-501.
2003: Betty Poon; Irvin S Y Chen
Human immunodeficiency virus type 1 (HIV-1) Vpr enhances expression from unintegrated HIV-1 DNA.
Journal of virology 2003;77(7):3962-72.
2003: Huidong Yuan; Yi-Ming Xie; Irvin S Y Chen
Depletion of Wee-1 kinase is necessary for both human immunodeficiency virus type 1 Vpr- and gamma irradiation-induced apoptosis.
Journal of virology 2003;77(3):2063-70.
2003: Xiao-Feng Qin; Dong Sung An; Irvin S Y Chen; David Baltimore
Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(1):183-8.
2003: Robert E Donahue; Irvin S Y Chen
Hematopoietic stem and progenitor cells.
Methods in molecular biology (Clifton, N.J.) 2003;229():117-30.
2003: Kouki Morizono; Daniel A De Ugarte; Min Zhu; Patricia A Zuk; Amir Elbarbary; Peter Ashjian; Prosper Benhaim; Irvin S Y Chen; Marc H Hedrick
Multilineage cells from adipose tissue as gene delivery vehicles.
Human gene therapy 2003;14(1):59-66.
2002: Yen-Hung Chow; Duan Yu; Jun-Ying Zhang; Yiming Xie; Olivia L Wei; Christopher Chiu; Mani Foroohar; Otto O Yang; No-Hee Park; Irvin S Y Chen; Shen Pang
gp120-Independent infection of CD4(-) epithelial cells and CD4(+) T-cells by HIV-1.
Journal of acquired immune deficiency syndromes (1999) 2002;30(1):1-8.
2002: Otto O Yang; Phuong Thi Nguyen; Spyros A Kalams; Tatyana Dorfman; Heinrich G Göttlinger; Sheila Stewart; Irvin S Y Chen; Steven Threlkeld; Bruce D Walker
Nef-mediated resistance of human immunodeficiency virus type 1 to antiviral cytotoxic T lymphocytes.
Journal of virology 2002;76(4):1626-31.
2002: Rafael G Amado; Irvin S Y Chen
Lentiviral vectors for gene therapy of HIV-induced disease.
Current topics in microbiology and immunology 2002;261():229-43.
2001: Michael A Poles; Julie Elliott; Philip Taing; Peter A Anton; Irvin S Y Chen
A preponderance of CCR5(+) CXCR4(+) mononuclear cells enhances gastrointestinal mucosal susceptibility to human immunodeficiency virus type 1 infection.
Journal of virology 2001;75(18):8390-9.
2001: Kouki Morizono; Gregory Bristol; Yi-Ming Xie; Sam K P Kung; Irvin S Y Chen
Antibody-directed targeting of retroviral vectors via cell surface antigens.
Journal of virology 2001;75(17):8016-20.
2001: E M Gaynor; Irvin S Y Chen
Analysis of apoptosis induced by HIV-1 Vpr and examination of the possible role of the hHR23A protein.
Experimental cell research 2001;267(2):243-57.
2001: Peter A Anton; Michael A Poles; Julie Elliott; Si-Hua Mao; Ian McGowan; H J Lenz; Irvin S Y Chen
Sensitive and reproducible quantitation of mucosal HIV-1 RNA and DNA viral burden in patients with detectable and undetectable plasma viral HIV-1 RNA using endoscopic biopsies.
Journal of virological methods 2001;95(1-2):65-79.
2001: Dong Sung An; Sam K P Kung; Aylin Bonifacino; RP Wersto; Mark E Metzger; Brian A Agricola; Si-Hua Mao; Irvin S Y Chen; Robert E Donahue
Lentivirus vector-mediated hematopoietic stem cell gene transfer of common gamma-chain cytokine receptor in rhesus macaques.
Journal of virology 2001;75(8):3547-55.
2001: Dong Sung An; Irvin S Y Chen
Envelope gene of the human endogenous retrovirus HERV-W encodes a functional retrovirus envelope.
Journal of virology 2001;75(7):3488-9.
2001: Robert E Donahue; Brian P Sorrentino; R G Hawley; Dong Sung An; Irvin S Y Chen; RP Wersto
Fibronectin fragment CH-296 inhibits apoptosis and enhances ex vivo gene transfer by murine retrovirus and human lentivirus vectors independent of viral tropism in nonhuman primate CD34+ cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;3(3):359-67.
2000: S Pang; D Yu; Dong Sung An; Gayle Cocita Baldwin; Y Xie; Betty Poon; Y H Chow; No-Hee Park; Irvin S Y Chen
Human immunodeficiency virus Env-independent infection of human CD4(-) cells.
Journal of virology 2000;74(23):10994-1000.
2000: E S Withers-Ward; Thomas D Mueller; Irvin S Y Chen; Juli Feigon
Biochemical and structural analysis of the interaction between the UBA(2) domain of the DNA repair protein HHR23A and HIV-1 Vpr.
Biochemistry 2000;39(46):14103-12.
2000: Kathie Grovit-Ferbas; JF Hsu; John Ferbas; V Gudeman; Irvin S Y Chen
Enhanced binding of antibodies to neutralization epitopes following thermal and chemical inactivation of human immunodeficiency virus type 1.
Journal of virology 2000;74(13):5802-9.
2000: Sam K P Kung; Dong Sung An; Irvin S Y Chen
A murine leukemia virus (MuLV) long terminal repeat derived from rhesus macaques in the context of a lentivirus vector and MuLV gag sequence results in high-level gene expression in human T lymphocytes.
Journal of virology 2000;74(8):3668-81.
2000: SA Stewart; Betty Poon; J Y Song; Irvin S Y Chen
Human immunodeficiency virus type 1 vpr induces apoptosis through caspase activation.
Journal of virology 2000;74(7):3105-11.
2000: Dong Sung An; RP Wersto; Brian A Agricola; Mark E Metzger; S Lu; Rafael G Amado; Irvin S Y Chen; Robert E Donahue
Marking and gene expression by a lentivirus vector in transplanted human and nonhuman primate CD34(+) cells.
Journal of virology 2000;74(3):1286-95.
1999: SA Stewart; Betty Poon; JB Jowett; Y Xie; Irvin S Y Chen
Lentiviral delivery of HIV-1 Vpr protein induces apoptosis in transformed cells.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(21):12039-43.
1999: Dong Sung An; Kouki Morizono; Q X Li; Si-Hua Mao; S Lu; Irvin S Y Chen
An inducible human immunodeficiency virus type 1 (HIV-1) vector which effectively suppresses HIV-1 replication.
Journal of virology 1999;73(9):7671-7.
1999: JB Jowett; Yi-Ming Xie; Irvin S Y Chen
The presence of human immunodeficiency virus type 1 Vpr correlates with a decrease in the frequency of mutations in a plasmid shuttle vector.
Journal of virology 1999;73(9):7132-7.
1999: Rafael G Amado; Irvin S Y Chen
Lentiviral vectors--the promise of gene therapy within reach?
Science (New York, N.Y.) 1999;285(5428):674-6.
1998: Kathie Grovit-Ferbas; John Ferbas; V Gudeman; S Sadeghi; Matthew Bidwell Goetz; Janis V Giorgi; Irvin S Y Chen; William A O'Brien
Potential contributions of viral envelope and host genetic factors in a human immunodeficiency virus type 1-infected long-term survivor.
Journal of virology 1998;72(11):8650-8.
1998: Betty Poon; Kathie Grovit-Ferbas; SA Stewart; Irvin S Y Chen
Cell cycle arrest by Vpr in HIV-1 virions and insensitivity to antiretroviral agents.
Science (New York, N.Y.) 1998;281(5374):266-9.
1998: LB Kong; D An; Bradley Ackerson; Jude Canon; Osvaldo Rey; Irvin S Y Chen; Paul Krogstad; Phoebe L Stewart
Cryoelectron microscopic examination of human immunodeficiency virus type 1 virions with mutations in the cyclophilin A binding loop.
Journal of virology 1998;72(5):4403-7.
1998: Betty Poon; Irvin S Y Chen
Identification of a domain within the human T-cell leukemia virus type 2 envelope required for syncytium induction and replication.
Journal of virology 1998;72(3):1959-66.
1997: E S Withers-Ward; JB Jowett; SA Stewart; Yi-Ming Xie; A Garfinkel; Y Shibagaki; Samson A Chow; N Shah; F Hanaoka; D G Sawitz; RW Armstrong; L M Souza; Irvin S Y Chen
Human immunodeficiency virus type 1 Vpr interacts with HHR23A, a cellular protein implicated in nucleotide excision DNA repair.
Journal of virology 1997;71(12):9732-42.
1997: E S Withers-Ward; Rafael G Amado; Prasad S Koka; Beth D Jamieson; Andrew H Kaplan; Irvin S Y Chen; Jerome A Zack
Transient renewal of thymopoiesis in HIV-infected human thymic implants following antiviral therapy.
Nature medicine 1997;3(10):1102-9.
1997: SA Stewart; Betty Poon; JB Jowett; Irvin S Y Chen
Human immunodeficiency virus type 1 Vpr induces apoptosis following cell cycle arrest.
Journal of virology 1997;71(7):5579-92.
1997: Betty Poon; JB Jowett; SA Stewart; RW Armstrong; G M Rishton; Irvin S Y Chen
Human immunodeficiency virus type 1 vpr gene induces phenotypic effects similar to those of the DNA alkylating agent, nitrogen mustard.
Journal of virology 1997;71(5):3961-71.
1997: Dong Sung An; Y Koyanagi; J Q Zhao; R Akkina; Gregory Bristol; N Yamamoto; Jerome A Zack; Irvin S Y Chen
High-efficiency transduction of human lymphoid progenitor cells and expression in differentiated T cells.
Journal of virology 1997;71(2):1397-404.
1996: SA Stewart; G Feuer; A Jewett; F V Lee; B Bonavida; Irvin S Y Chen
HTLV-1 gene expression in adult T-cell leukemia cells elicits an NK cell response in vitro and correlates with cell rejection in SCID mice.
Virology 1996;226(2):167-75.
1996: Paul Krogstad; Irvin S Y Chen; Jude Canon; Osvaldo Rey
Quantitative analysis of the endogenous reverse transcriptase reactions of HIV type 1 variants with decreased susceptibility to azidothymidine and nevirapine.
AIDS research and human retroviruses 1996;12(11):977-83.
1996: G Feuer; John K Fraser; Jerome A Zack; F Lee; R Feuer; Irvin S Y Chen
Human T-cell leukemia virus infection of human hematopoietic progenitor cells: maintenance of virus infection during differentiation in vitro and in vivo.
Journal of virology 1996;70(6):4038-44.
1996: William A O'Brien; M Sumner-Smith; S H Mao; S Sadeghi; J Q Zhao; Irvin S Y Chen
Anti-human immunodeficiency virus type 1 activity of an oligocationic compound mediated via gp120 V3 interactions.
Journal of virology 1996;70(5):2825-31.
1996: R K Akkina; R M Walton; M L Chen; Q X Li; Vicente Planelles; Irvin S Y Chen
High-efficiency gene transfer into CD34+ cells with a human immunodeficiency virus type 1-based retroviral vector pseudotyped with vesicular stomatitis virus envelope glycoprotein G.
Journal of virology 1996;70(4):2581-5.
1996: Vicente Planelles; JB Jowett; Q X Li; Y Xie; B Hahn; Irvin S Y Chen
Vpr-induced cell cycle arrest is conserved among primate lentiviruses.
Journal of virology 1996;70(4):2516-24.
1996: Q X Li; D Camerini; Y Xie; M Greenwald; D R Kuritzkes; Irvin S Y Chen
Syncytium formation by recombinant HTLV-II envelope glycoprotein.
Virology 1996;218(1):279-84.
1996: G L Cockerell; Joel Rovnak; P L Green; Irvin S Y Chen
A deletion in the proximal untranslated pX region of human T-cell leukemia virus type II decreases viral replication but not infectivity in vivo.
Blood 1996;87(3):1030-5.
1995: Q X Li; D Camerini; D R Kuritzkes; Irvin S Y Chen
Rapid generation of antibodies against the HTLV-II external envelope protein by growth of mouse plasmacytomas in SCID mice.
Virology 1995;214(2):680-4.
1995: T Masuda; Vicente Planelles; Paul Krogstad; Irvin S Y Chen
Genetic analysis of human immunodeficiency virus type 1 integrase and the U3 att site: unusual phenotype of mutants in the zinc finger-like domain.
Journal of virology 1995;69(11):6687-96.
1995: JB Jowett; Vicente Planelles; Betty Poon; N P Shah; M L Chen; Irvin S Y Chen
The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle.
Journal of virology 1995;69(10):6304-13.
1995: Vicente Planelles; F Bachelerie; JB Jowett; A Haislip; Y Xie; P Banooni; T Masuda; Irvin S Y Chen
Fate of the human immunodeficiency virus type 1 provirus in infected cells: a role for vpr.
Journal of virology 1995;69(9):5883-9.
1995: Vicente Planelles; A Haislip; E S Withers-Ward; SA Stewart; Y Xie; N P Shah; Irvin S Y Chen
A new reporter system for detection of retroviral infection.
Gene therapy 1995;2(6):369-76.
1995: Yvonne Bryson; S Pang; L S Wei; Ruth Dickover; A Diagne; Irvin S Y Chen
Clearance of HIV infection in a perinatally infected infant.
The New England journal of medicine 1995;332(13):833-8.
1995: G Feuer; SA Stewart; S M Baird; F Lee; R Feuer; Irvin S Y Chen
Potential role of natural killer cells in controlling tumorigenesis by human T-cell leukemia viruses.
Journal of virology 1995;69(2):1328-33.
1995: Eric S Daar; T Chernyavskiy; J Q Zhao; Paul Krogstad; Irvin S Y Chen; Jerome A Zack
Sequential determination of viral load and phenotype in human immunodeficiency virus type 1 infection.
AIDS research and human retroviruses 1995;11(1):3-9.
1994: R K Akkina; Joseph D Rosenblatt; A G Campbell; Irvin S Y Chen; Jerome A Zack
Modeling human lymphoid precursor cell gene therapy in the SCID-hu mouse.
Blood 1994;84(5):1393-8.
1994: Beth D Jamieson; Grace M Aldrovandi; Vicente Planelles; JB Jowett; L Gao; L M Bloch; Irvin S Y Chen; Jerome A Zack
Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity.
Journal of virology 1994;68(6):3478-85.
1994: Irvin S Y Chen; Jerome A Zack
Modeling human retroviral pathogenesis and antiretroviral gene therapy in the SCID mouse.
Research in immunology 1994;145(5):385-92.
1994: Paul Krogstad; Jerome A Zack; Irvin S Y Chen
HIV-1 reverse transcription in cord blood lymphocytes: implications for infection of newborns.
AIDS research and human retroviruses 1994;10(2):143-7.
1994: William A O'Brien; A Namazi; H Kalhor; S H Mao; Jerome A Zack; Irvin S Y Chen
Kinetics of human immunodeficiency virus type 1 reverse transcription in blood mononuclear phagocytes are slowed by limitations of nucleotide precursors.
Journal of virology 1994;68(2):1258-63.
1993: A R Sperduto; Y J Bryson; Irvin S Y Chen
Increased susceptibility of neonatal monocyte/macrophages to HIV-1 infection.
AIDS research and human retroviruses 1993;9(12):1277-85.
1993: G Feuer; Jerome A Zack; William J Harrington; R Valderama; Joseph D Rosenblatt; W Wachsman; S M Baird; Irvin S Y Chen
Establishment of human T-cell leukemia virus type I T-cell lymphomas in severe combined immunodeficient mice.
Blood 1993;82(3):722-31.
1993: Grace M Aldrovandi; G Feuer; L Gao; Beth D Jamieson; M Kristeva; Irvin S Y Chen; Jerome A Zack
The SCID-hu mouse as a model for HIV-1 infection.
Nature 1993;363(6431):732-6.
1992: G Feuer; Irvin S Y Chen
Mechanisms of human T-cell leukemia virus-induced leukemogenesis.
Biochimica et biophysica acta 1992;1114(2-3):223-33.
1992: P L Green; M T Yip; Y Xie; Irvin S Y Chen
Phosphorylation regulates RNA binding by the human T-cell leukemia virus Rex protein.
Journal of virology 1992;66(7):4325-30.
1992: S Pang; Y Shlesinger; Eric S Daar; T Moudgil; David D Ho; Irvin S Y Chen
Rapid generation of sequence variation during primary HIV-1 infection.
AIDS (London, England) 1992;6(5):453-60.
1992: William A O'Brien; Irvin S Y Chen; David D Ho; Eric S Daar
Mapping genetic determinants for human immunodeficiency virus type 1 resistance to soluble CD4.
Journal of virology 1992;66(5):3125-30.
1992: J E Merrill; Y Koyanagi; Jerome A Zack; L Thomas; F Martin; Irvin S Y Chen
Induction of interleukin-1 and tumor necrosis factor alpha in brain cultures by human immunodeficiency virus type 1.
Journal of virology 1992;66(4):2217-25.
1992: Jerome A Zack; A M Haislip; Paul Krogstad; Irvin S Y Chen
Incompletely reverse-transcribed human immunodeficiency virus type 1 genomes in quiescent cells can function as intermediates in the retroviral life cycle.
Journal of virology 1992;66(3):1717-25.
1992: Elizabeth A Rich; Irvin S Y Chen; Jerome A Zack; M L Leonard; William A O'Brien
Increased susceptibility of differentiated mononuclear phagocytes to productive infection with human immunodeficiency virus-1 (HIV-1).
The Journal of clinical investigation 1992;89(1):176-83.
1991: A C Black; C T Ruland; M T Yip; J Luo; B Tran; A Kalsi; E Quan; M Aboud; Irvin S Y Chen; Joseph D Rosenblatt
Human T-cell leukemia virus type II Rex binding and activity require an intact splice donor site and a specific RNA secondary structure.
Journal of virology 1991;65(12):6645-53.
1991: G L Cockerell; M G Weiser; Joel Rovnak; B Wicks-Beard; B Roberts; A Post; Irvin S Y Chen; Michael D Lairmore
Infectious transmission of human T-cell lymphotropic virus type II in rabbits.
Blood 1991;78(6):1532-7.
1991: M T Yip; William S Dynan; P L Green; A C Black; SJ Arrigo; A Torbati; Shaun Heaphy; C Ruland; Joseph D Rosenblatt; Irvin S Y Chen
Human T-cell leukemia virus (HTLV) type II Rex protein binds specifically to RNA sequences of the HTLV long terminal repeat but poorly to the human immunodeficiency virus type 1 Rev-responsive element.
Journal of virology 1991;65(5):2261-72.
1991: SJ Arrigo; Irvin S Y Chen
Rev is necessary for translation but not cytoplasmic accumulation of HIV-1 vif, vpr, and env/vpu 2 RNAs.
Genes & development 1991;5(5):808-19.
1991: A C Black; Irvin S Y Chen; SJ Arrigo; C T Ruland; T Allogiamento; E Chin; Joseph D Rosenblatt
Regulation of HTLV-II gene expression by Rex involves positive and negative cis-acting elements in the 5'long terminal repeat.
Virology 1991;181(2):433-44.
1991: P L Green; Yi-Ming Xie; Irvin S Y Chen
The Rex proteins of human T-cell leukemia virus type II differ by serine phosphorylation.
Journal of virology 1991;65(1):546-50.
1991: S Pang; Harry V Vinters; T Akashi; William A O'Brien; Irvin S Y Chen
HIV-1 env sequence variation in brain tissue of patients with AIDS-related neurologic disease.
Journal of acquired immune deficiency syndromes 1991;4(11):1082-92.
1990: William A O'Brien; Y Koyanagi; A Namazie; J Q Zhao; A Diagne; K Idler; Jerome A Zack; Irvin S Y Chen
HIV-1 tropism for mononuclear phagocytes can be determined by regions of gp120 outside the CD4-binding domain.
Nature 1990;348(6296):69-73.
1990: P L Green; Yi-Ming Xie; Irvin S Y Chen
The internal methionine codons of human T-cell leukemia virus type II rex gene are not required for p24rex production or virus replication and transformation.
Journal of virology 1990;64(10):4914-21.
1990: AJ Cann; Jerome A Zack; Alan S Go; SJ Arrigo; Y Koyanagi; P L Green; Y Koyanagi; S Pang; Irvin S Y Chen
Human immunodeficiency virus type 1 T-cell tropism is determined by events prior to provirus formation.
Journal of virology 1990;64(10):4735-42.
1990: Irvin S Y Chen; A M Haislip; LW Myers; GW Ellison; JE Merrill
Failure to detect human T-cell leukemia virus-related sequences in multiple sclerosis blood.
Archives of neurology 1990;47(10):1064-5.
1990: SJ Arrigo; Stacy R Weitsman; Jerome A Zack; Irvin S Y Chen
Characterization and expression of novel singly spliced RNA species of human immunodeficiency virus type 1.
Journal of virology 1990;64(9):4585-8.
1990: Joseph D Rosenblatt; S Plaeger-Marshall; Janis V Giorgi; P Swanson; Irvin S Y Chen; E Chin; H J Wang; M Canavaggio; Mary Ann Hausner; A C Black
A clinical, hematologic, and immunologic analysis of 21 HTLV-II-infected intravenous drug users.
Blood 1990;76(2):409-17.
1990: Gayle Cocita Baldwin; J Fleischmann; Y Chung; Y Koyanagi; Irvin S Y Chen; David W Golde
Human immunodeficiency virus causes mononuclear phagocyte dysfunction.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(10):3933-7.
1990: Jerome A Zack; SJ Arrigo; Stacy R Weitsman; Alan S Go; A Haislip; Irvin S Y Chen
HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure.
Cell 1990;61(2):213-22.
1990: P L Green; Irvin S Y Chen
Regulation of human T cell leukemia virus expression.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1990;4(2):169-75.
1990: M T Yip; Irvin S Y Chen
Modes of transformation by the human T-cell leukemia viruses.
Molecular biology & medicine 1990;7(1):33-44.
1990: Joseph D Rosenblatt; Jerome A Zack; Irvin S Y Chen; H Lee
Recent advances in detection of human T-cell leukemia viruses type I and type II infection.
Natural immunity and cell growth regulation 1990;9(3):143-9.
1990: William A O'Brien; Jerome A Zack; Irvin S Y Chen
Molecular pathogenesis of HIV-1.
AIDS (London, England) 1990;4 Suppl 1():S41-8.
1990: Jerome A Zack; SJ Arrigo; Irvin S Y Chen
Control of expression and cell tropism of human immunodeficiency virus type 1.
Advances in virus research 1990;38():125-46.
1989: SJ Arrigo; Stacy R Weitsman; Joseph D Rosenblatt; Irvin S Y Chen
Analysis of rev gene function on human immunodeficiency virus type 1 replication in lymphoid cells by using a quantitative polymerase chain reaction method.
Journal of virology 1989;63(11):4875-81.
1989: J L Williams; AJ Cann; Todd Leff; P Sassone-Corsi; Irvin S Y Chen
Studies of heterologous promoter trans-activation by the HTLV-II tax protein.
Nucleic acids research 1989;17(14):5737-49.
1989: E H Saxton; H Lee; P Swanson; Irvin S Y Chen; C Ruland; E Chin; D Aboulafia; Rick B Delamarter; Joseph D Rosenblatt
Detection of human T-cell leukemia/lymphoma virus type I in a transfusion recipient with chronic myelopathy.
Neurology 1989;39(6):841-4.
1989: Stephen D Nimer; Judith C Gasson; K Hu; I Smalberg; J L Williams; Irvin S Y Chen; Joseph D Rosenblatt
Activation of the GM-CSF promoter by HTLV-I and -II tax proteins.
Oncogene 1989;4(6):671-6.
1989: AJ Cann; Joseph D Rosenblatt; W Wachsman; Irvin S Y Chen
In vitro mutagenesis of the human T-cell leukemia virus types I and II tax genes.
Journal of virology 1989;63(3):1474-9.
1989: JE Merrill; J M Kagan; Ingrid Schmid; S R Strom; S G Quan; Irvin S Y Chen
T cell lines established from multiple sclerosis cerebrospinal fluid T cells using human retroviruses.
Journal of neuroimmunology 1989;21(2-3):213-26.
1988: Y Koyanagi; William A O'Brien; J Q Zhao; David W Golde; Judith C Gasson; Irvin S Y Chen
Cytokines alter production of HIV-1 from primary mononuclear phagocytes.
Science (New York, N.Y.) 1988;241(4873):1673-5.
1988: Joseph D Rosenblatt; Irvin S Y Chen; W Wachsman
Infection with HTLV-I and HTLV-II: evolving concepts.
Seminars in hematology 1988;25(3):230-46.
1988: S Plaeger-Marshall; A Haas; L T Clement; Janis V Giorgi; Irvin S Y Chen; S G Quan; Richard A Gatti; E Richard Stiehm
Interferon-induced expression of class II major histocompatibility antigens in the major histocompatibility complex (MHC) class II deficiency syndrome.
Journal of clinical immunology 1988;8(4):285-95.
1988: Jerome A Zack; AJ Cann; J P Lugo; Irvin S Y Chen
HIV-1 production from infected peripheral blood T cells after HTLV-I induced mitogenic stimulation.
Science (New York, N.Y.) 1988;240(4855):1026-9.
1988: Joseph D Rosenblatt; AJ Cann; Dennis J Slamon; I S Smalberg; N P Shah; J Fujii; W Wachsman; Irvin S Y Chen
HTLV-II transactivation is regulated by the overlapping tax/rex nonstructural genes.
Science (New York, N.Y.) 1988;240(4854):916-9.
1988: Joseph D Rosenblatt; Irvin S Y Chen; David W Golde
HTLV-II and human lymphoproliferative disorders.
Clinics in laboratory medicine 1988;8(1):85-95.
1988: Joseph D Rosenblatt; Janis V Giorgi; David W Golde; J B Ezra; A Wu; C D Winberg; J Glaspy; W Wachsman; Irvin S Y Chen
Integrated human T-cell leukemia virus II genome in CD8 + T cells from a patient with "atypical" hairy cell leukemia: evidence for distinct T and B cell lymphoproliferative disorders.
Blood 1988;71(2):363-9.
1987: Joseph D Rosenblatt; Judith C Gasson; J Glaspy; S Bhuta; M Aboud; Irvin S Y Chen; David W Golde
Relationship between human T cell leukemia virus-II and atypical hairy cell leukemia: a serologic study of hairy cell leukemia patients.
Leukemia 1987;1(4):397-401.
1987: H Kitado; Irvin S Y Chen; N P Shah; AJ Cann; K Shimotohno; H Fan
U3 sequences from HTLV-I and -II LTRs confer pX protein response to a murine leukemia virus LTR.
Science (New York, N.Y.) 1987;235(4791):901-4.
1987: W Wachsman; AJ Cann; J L Williams; Dennis J Slamon; L Souza; N P Shah; Irvin S Y Chen
HTLV x gene mutants exhibit novel transcriptional regulatory phenotypes.
Science (New York, N.Y.) 1987;235(4789):674-7.
1986: N P Shah; W Wachsman; AJ Cann; L Souza; Dennis J Slamon; Irvin S Y Chen
Comparison of the trans-activation capabilities of the human T-cell leukemia virus type I and II chi proteins.
Molecular and cellular biology 1986;6(11):3626-31.
1986: Joseph D Rosenblatt; David W Golde; W Wachsman; Janis V Giorgi; A Jacobs; G M Schmidt; S Quan; Judith C Gasson; Irvin S Y Chen
A second isolate of HTLV-II associated with atypical hairy-cell leukemia.
The New England journal of medicine 1986;315(6):372-7.
1986: Irvin S Y Chen; W Wachsman; Joseph D Rosenblatt; AJ Cann
The role of the x gene in HTLV associated malignancy.
Cancer surveys 1986;5(2):329-42.
1985: AJ Cann; Joseph D Rosenblatt; W Wachsman; N P Shah; Irvin S Y Chen
Identification of the gene responsible for human T-cell leukaemia virus transcriptional regulation.
Nature 1985;318(6046):571-4.
1985: Irvin S Y Chen; AJ Cann; N P Shah; R B Gaynor
Functional relation between HTLV-II x and adenovirus E1A proteins in transcriptional activation.
Science (New York, N.Y.) 1985;230(4725):570-3.
1985: Irvin S Y Chen; Dennis J Slamon; Joseph D Rosenblatt; N P Shah; S G Quan; W Wachsman
The x gene is essential for HTLV replication.
Science (New York, N.Y.) 1985;229(4708):54-8.
1985: Dennis J Slamon; Michael F Press; L M Souza; D C Murdock; M J Cline; D W Golde; J C Gasson; Irvin S Y Chen
Studies of the putative transforming protein of the type I human T-cell leukemia virus.
Science (New York, N.Y.) 1985;228(4706):1427-30.