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Jianzhu Chen

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Na Li; Gino Limmon; Damien Thévenin; Yoshiyuki Yamada; Lu Yin; Jianzhu Chen; Vincent Tk Chow; Donald M Engelman; Bevin P Engelward
Peptide targeting and imaging of damaged lung tissue in influenza-infected mice.
Chia Min Lee; Ling Wang; Alisha K Weight; Jayanta Haldar; Alexander M Klibanov; Jianzhu Chen
Polymer-attached zanamivir inhibits synergistically both early and late stages of influenza virus infection.
Qingfeng Chen; Fang He; Jimmy Kwang; Jerry K Y Chan; Jianzhu Chen
GM-CSF and IL-4 stimulate antibody responses in humanized mice by promoting T, B, and dendritic cell maturation.

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2013: Na Li; Gino Limmon; Damien Thévenin; Yoshiyuki Yamada; Lu Yin; Jianzhu Chen; Vincent Tk Chow; Donald M Engelman; Bevin P Engelward
Peptide targeting and imaging of damaged lung tissue in influenza-infected mice.
Future microbiology 2013;8(2):257-69.
2012: Chia Min Lee; Ling Wang; Alisha K Weight; Jayanta Haldar; Alexander M Klibanov; Jianzhu Chen
Polymer-attached zanamivir inhibits synergistically both early and late stages of influenza virus infection.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(50):20385-90.
2012: Qingfeng Chen; Fang He; Jimmy Kwang; Jerry K Y Chan; Jianzhu Chen
GM-CSF and IL-4 stimulate antibody responses in humanized mice by promoting T, B, and dendritic cell maturation.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(11):5223-9.
2012: Alyssa M Larson; Hongmei Wang; Yang Cao; Jianzhu Chen; Taijiao Jiang; Alexander M Klibanov
Conjugating drug candidates to polymeric chains does not necessarily enhance anti-influenza activity.
Journal of pharmaceutical sciences 2012;101(10):3896-905.
2012: S Peter Bak; Mike Stein Barnkob; Eileen M Higham; K Dane Wittrup; Ailin Bai; Jianzhu Chen
Differential requirement for CD70 and CD80/CD86 in dendritic cell-mediated activation of tumor-tolerized CD8 T cells.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(4):1708-16.
2012: Matthias T Stephan; Sirkka B Stephan; Peter Bak; Jianzhu Chen; Darrell J Irvine
Synapse-directed delivery of immunomodulators using T-cell-conjugated nanoparticles.
Biomaterials 2012;33(23):5776-87.
2012: Adam C Drake; Qingfeng Chen; Jianzhu Chen
Engineering humanized mice for improved hematopoietic reconstitution.
Cellular & molecular immunology 2012;9(3):215-24.
2012: Roger A Nassar; Edward P Browne; Jianzhu Chen; Alexander M Klibanov
Removing human immunodeficiency virus (HIV) from human blood using immobilized heparin.
Biotechnology letters 2012;34(5):853-6.
2012: David N Nguyen; Alain P Vicari; Jianzhu Chen; Steve Chen; Ghania Chikh; Hattie Chung; Michael Goldberg; Phillip Kim; Arthur M Krieg; Robert Langer; Kevin T Love; Kerry P Mahon; Daniel G Anderson
Lipid-derived nanoparticles for immunostimulatory RNA adjuvant delivery.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(14):E797-803.
2012: Herman N Eisen; Xun Helen Hou; Katerina Kozyrytska; Carol A McKinley; Lakshmi Nambiar; Chase Shen; Crysela Smith; Varsha Keelara Tanguturi; Kaidi Wang; Jianzhu Chen; Richard J Cohen
Promiscuous binding of extracellular peptides to cell surface class I MHC protein.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(12):4580-5.
2012: Jinkee Hong; Jong Bum Lee; Nisarg J Shah; Jianzhu Chen; Peter C DeMuth; Adam C Drake; Paula T Hammond
Graphene multilayers as gates for multi-week sequential release of proteins from surfaces.
ACS nano 2012;6(1):81-8.
2012: Dahai Zheng; Vincent T K Chow; Nicola H N Leung; Gino V Limmon; Lu Yin; Hanry Yu; Jianzhu Chen
Regeneration of alveolar type I and II cells from Scgb1a1-expressing cells following severe pulmonary damage induced by bleomycin and influenza.
PloS one 2012;7(10):e48451.
2012: Yoshiyuki Yamada; Lu Yin; Dahai Zheng; Jianzhu Chen; Vincent T K Chow; Liang Li; Na Li; Gino V Limmon; Bevin P Engelward
Major shifts in the spatio-temporal distribution of lung antioxidant enzymes during influenza pneumonia.
PloS one 2012;7(2):e31494.
2011: Mobolaji O Olurinde; Ching-Hung Shen; Ailin Bai; Adam Drake; Jianzhu Chen
Persistence of tumor-infiltrating CD8 T cells is tumor-dependent but antigen-independent.
Cellular & molecular immunology 2011;8(5):415-23.
2011: Xilai Ding; Peishuang Du; Zhihai Qin; Xiaodong Shi; Lishan Su; Wei Yang; Jianzhu Chen; Hongyu Deng
TNF receptor 1 mediates dendritic cell maturation and CD8 T cell response through two distinct mechanisms.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(3):1184-91.
2011: Maroun Khoury; Ilya Leskov; Yan Li; Harvey F Lodish; Qingfeng Chen; Di Dong; Adam Drake; Maria F Fragoso; William Hwang; Bettina P Iliopoulou; Jianzhu Chen
Mesenchymal stem cells secreting angiopoietin-like-5 support efficient expansion of human hematopoietic stem cells without compromising their repopulating potential.
Stem cells and development 2011;20(8):1371-81.
2011: Megan J Palmer; Vinay S Mahajan; Jianzhu Chen; Darrell J Irvine; Douglas A Lauffenburger
Signaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of naïve CD8(+) T cells.
Immunology and cell biology 2011;89(5):581-94.
2011: Wei Yang; Xilai Ding; Jingjing Deng; Yu Lu; Zene Matsuda; Andreas Thiel; Jianzhu Chen; Hongyu Deng; Zhihai Qin
Interferon-gamma negatively regulates Th17-mediated immunopathology during mouse hepatitis virus infection.
Journal of molecular medicine (Berlin, Germany) 2011;89(4):399-409.
2011: Alyssa M Larson; Bryan B Hsu; Debabrata Rautaray; Jayanta Haldar; Jianzhu Chen; Alexander M Klibanov
Hydrophobic polycationic coatings disinfect poliovirus and rotavirus solutions.
Biotechnology and bioengineering 2011;108(3):720-3.
2011: Alisha K Weight; Jayanta Haldar; Luis Alvarez de Cienfuegos; Larisa V Gubareva; Terrence M Tumpey; Jianzhu Chen; Alexander M Klibanov
Attaching zanamivir to a polymer markedly enhances its activity against drug-resistant strains of influenza a virus.
Journal of pharmaceutical sciences 2011;100(3):831-5.
2011: Noa Novershtern; Aravind Subramanian; Lee N Lawton; Raymond H Mak; W Nicholas Haining; Marie E McConkey; Naomi Habib; Nir Yosef; Cindy Y Chang; Tal Shay; Garrett M Frampton; Adam C B Drake; Ilya Leskov; Bjorn Nilsson; Fred Preffer; David Dombkowski; John W Evans; Ted Liefeld; John S Smutko; Jianzhu Chen; Nir Friedman; Richard A Young; Todd R Golub; Aviv Regev; Benjamin L Ebert
Densely interconnected transcriptional circuits control cell states in human hematopoiesis.
Cell 2011;144(2):296-309.
2011: Michel DuPage; Ann F Cheung; Claire Mazumdar; Monte M Winslow; Roderick Bronson; Leah M Schmidt; Denise Crowley; Jianzhu Chen; Tyler Jacks
Endogenous T cell responses to antigens expressed in lung adenocarcinomas delay malignant tumor progression.
Cancer cell 2011;19(1):72-85.
2011: Bryan B Hsu; Sze Yinn Wong; Paula T Hammond; Jianzhu Chen; Alexander M Klibanov
Mechanism of inactivation of influenza viruses by immobilized hydrophobic polycations.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(1):61-6.
2011: Steve C-Y Chen; Zhuyan Guo; Patrick Stern; Jianzhu Chen
Expression of multiple artificial microRNAs from a chicken miRNA126-based lentiviral vector.
PloS one 2011;6(7):e22437.
2011: Adam C Drake; Maroun Khoury; Ilya Leskov; Bettina P Iliopoulou; Maria Fragoso; Harvey Lodish; Jianzhu Chen
Human CD34+ CD133+ hematopoietic stem cells cultured with growth factors including Angptl5 efficiently engraft adult NOD-SCID Il2rγ-/- (NSG) mice.
PloS one 2011;6(4):e18382.
2011: Yang Cao; Xiaoying Koh; Libo Dong; Xiangjun Du; Aiping Wu; Xilai Ding; Hongyu Deng; Yuelong Shu; Jianzhu Chen; Taijiao Jiang
Rapid estimation of binding activity of influenza virus hemagglutinin to human and avian receptors.
PloS one 2011;6(4):e18664.
2010: Ching-Hung Shen; Oezcan Talay; Vinay S Mahajan; Ilya B Leskov; Herman N Eisen; Jianzhu Chen
Antigen-bearing dendritic cells regulate the diverse pattern of memory CD8 T-cell development in different tissues.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(52):22587-92.
2010: J C Miguel; Jianzhu Chen; William G Van Alstine; Rodney W Johnson
Expression of inflammatory cytokines and Toll-like receptors in the brain and respiratory tract of pigs infected with porcine reproductive and respiratory syndrome virus.
Veterinary immunology and immunopathology 2010;135(3-4):314-9.
2010: Eileen M Higham; Ching-Hung Shen; K Dane Wittrup; Jianzhu Chen
Cutting edge: delay and reversal of T cell tolerance by intratumoral injection of antigen-loaded dendritic cells in an autochthonous tumor model.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(11):5954-8.
2010: Eileen M Higham; K Dane Wittrup; Jianzhu Chen
Activation of tolerogenic dendritic cells in the tumor draining lymph nodes by CD8+ T cells engineered to express CD40 ligand.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(7):3394-400.
2010: Diana Hooi Ping Low; Vladimir Frecer; Agnès Le Saux; Ganesh Anand Srinivasan; Bow Ho; Jianzhu Chen; Jeak Ling Ding
Molecular interfaces of the galactose-binding protein Tectonin domains in host-pathogen interaction.
The Journal of biological chemistry 2010;285(13):9898-907.
2010: LiGuo Zhang; Eric Meissner; Jianzhu Chen; LiShan Su
Current humanized mouse models for studying human immunology and HIV-1 immuno-pathogenesis.
Science China. Life sciences 2010;53(2):195-203.
2010: Jayanta Haldar; Luis Alvarez de Cienfuegos; Terrence M Tumpey; Larisa V Gubareva; Jianzhu Chen; Alexander M Klibanov
Bifunctional polymeric inhibitors of human influenza A viruses.
Pharmaceutical research 2010;27(2):259-63.
2009: Qingfeng Chen; Maroun Khoury; Jianzhu Chen
Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(51):21783-8.
2009: L Elia; M Quintavalle; Jun Zhang; R Contu; L Cossu; Michael V G Latronico; Kirk L Peterson; C Indolfi; Daniele Catalucci; Jianzhu Chen; S A Courtneidge; Gianluigi Condorelli
The knockout of miR-143 and -145 alters smooth muscle cell maintenance and vascular homeostasis in mice: correlates with human disease.
Cell death and differentiation 2009;16(12):1590-8.
2009: David N Nguyen; Steve C-Y Chen; James Lu; Michael Goldberg; Phillip Kim; Andrew Sprague; Tatiana Novobrantseva; Jennifer Sherman; Svetlana Shulga-Morskaya; Antonin de Fougerolles; Jianzhu Chen; Robert Langer; Daniel G Anderson
Drug delivery-mediated control of RNA immunostimulation.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(9):1555-62.
2009: Adam S Chervin; Jennifer D Stone; Phillip D Holler; Ailin Bai; Jianzhu Chen; Herman N Eisen; David M Kranz
The impact of TCR-binding properties and antigen presentation format on T cell responsiveness.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(2):1166-78.
2009: James J Lu; Robert Langer; Jianzhu Chen
A novel mechanism is involved in cationic lipid-mediated functional siRNA delivery.
Molecular pharmaceutics 2009;6(3):763-71.
2009: Yuhua Hu; Prabhani U Atukorale; James J Lu; James J Moon; Soong Ho Um; Eun Chol Cho; Yana Wang; Jianzhu Chen; Darrell J Irvine
Cytosolic delivery mediated via electrostatic surface binding of protein, virus, or siRNA cargos to pH-responsive core-shell gel particles.
Biomacromolecules 2009;10(4):756-65.
2009: Hilde-Kari Guttormsen; Lynda M Stuart; Lei Shi; Mike C Carroll; Jianzhu Chen; Dennis L Kasper; R Alan B Ezekowitz; Kazue Takahashi
Deficiency of mannose-binding lectin greatly increases antibody response in a mouse model of vaccination.
Clinical immunology (Orlando, Fla.) 2009;130(3):264-71.
2009: Oezcan Talay; Ching-Hung Shen; Lieping Chen; Jianzhu Chen
B7-H1 (PD-L1) on T cells is required for T-cell-mediated conditioning of dendritic cell maturation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(8):2741-6.
2009: Diana Hooi Ping Low; Zhiwei Ang; Quan Yuan; Vladimir Frecer; Bow Ho; Jianzhu Chen; Jeak Ling Ding
A novel human tectonin protein with multivalent beta-propeller folds interacts with ficolin and binds bacterial LPS.
PloS one 2009;4(7):e6260.
2009: Sebastian Leptihn; Jia Yi Har; Jianzhu Chen; Bow Ho; Thorsten Wohland; Jeak Ling Ding
Single molecule resolution of the antimicrobial action of quantum dot-labeled sushi peptide on live bacteria.
BMC biology 2009;7():22.
2009: Vinay S Mahajan; Adam Drake; Jianzhu Chen
Virus-specific host miRNAs: antiviral defenses or promoters of persistent infection?
Trends in immunology 2009;30(1):1-7.
2008: Ann F Cheung; Michel J P Dupage; H Katie Dong; Jianzhu Chen; Tyler Jacks
Regulated expression of a tumor-associated antigen reveals multiple levels of T-cell tolerance in a mouse model of lung cancer.
Cancer research 2008;68(22):9459-68.
2008: Ailin Bai; Eileen Higham; Herman N Eisen; K Dane Wittrup; Jianzhu Chen
Rapid tolerization of virus-activated tumor-specific CD8+ T cells in prostate tumors of TRAMP mice.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(35):13003-8.
2008: Chun Jeih Ryu; Charles E Whitehurst; Jianzhu Chen
Expression of Gal4-VP16 and Gal4-DNA binding domain under the control of the T lymphocyte-specific lck proximal promoter in transgenic mice.
BMB reports 2008;41(8):575-80.
2008: Olivier Kocher; Ayce Yesilaltay; Ching-Hung Shen; Songwen Zhang; Kathleen Daniels; Rinku Pal; Jianzhu Chen; Monty Krieger
Influence of PDZK1 on lipoprotein metabolism and atherosclerosis.
Biochimica et biophysica acta 2008;1782(5):310-6.
2008: Megan J Palmer; Vinay S Mahajan; Lily C Trajman; Darrell J Irvine; Douglas A Lauffenburger; Jianzhu Chen
Interleukin-7 receptor signaling network: an integrated systems perspective.
Cellular & molecular immunology 2008;5(2):79-89.
2008: Jayanta Haldar; Jianzhu Chen; Terrence M Tumpey; Larisa V Gubareva; Alexander M Klibanov
Hydrophobic polycationic coatings inactivate wild-type and zanamivir- and/or oseltamivir-resistant human and avian influenza viruses.
Biotechnology letters 2008;30(3):475-9.
2008: Jianzhu Chen; Steve C-Y Chen; Patrick Stern; Benjamin B Scott; Carlos Lois
Genetic strategy to prevent influenza virus infections in animals.
The Journal of infectious diseases 2008;197 Suppl 1():S25-8.
2008: Qibin Leng; Yuchun Nie; Yongrui Zou; Jianzhu Chen
Elevated CXCL12 expression in the bone marrow of NOD mice is associated with altered T cell and stem cell trafficking and diabetes development.
BMC immunology 2008;9():51.
2008: Ching-Hung Shen; Qing Ge; Oezcan Talay; Herman N Eisen; Adolfo García-Sastre; Jianzhu Chen
Loss of IL-7R and IL-15R expression is associated with disappearance of memory T cells in respiratory tract following influenza infection.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(1):171-8.
2008: Christine Vaculik; Beate Rüger; Genya Yanagida; David Hollemann; Afschin Soleiman; Udo M Losert; Jianzhu Chen; Michael B Fischer
Shift of C3 deposition from localization in the glomerulus into the tubulo-interstitial compartment in the absence of secreted IgM in immune complex glomerulonephritis.
Clinical and experimental immunology 2008;151(1):146-54.
2007: Michael B Fischer; Beate Rüger; Christine Vaculik; Alexander Becherer; Wolfgang Wadsak; Genya Yanagida; Udo M Losert; Jianzhu Chen; Michael C Carroll; Martha M Eibl
The presence of MOMA-2+ macrophages in the outer B cell zone and protection of the splenic micro-architecture from LPS-induced destruction depend on secreted IgM.
European journal of immunology 2007;37(10):2825-33.
2007: Zhongyi Cong; Min Wan; Xiuli Wu; Liying Wang; Xiaoping Hu; Fenglei Yang; Musheng Bao; Xuesong Zhang; Jianzhu Chen; Li Wang; Yongli Yu
A CpG oligodeoxynucleotide inducing anti-coxsackie B3 virus activity in human peripheral blood mononuclear cells.
FEMS immunology and medical microbiology 2007;51(1):26-34.
2007: Mini Thomas; James J Lu; Chengcheng Zhang; Jianzhu Chen; Alexander M Klibanov
Identification of novel superior polycationic vectors for gene delivery by high-throughput synthesis and screening of a combinatorial library.
Pharmaceutical research 2007;24(8):1564-71.
2007: Ailin Bai; Hui Hu; Mandy Yeung; Jianzhu Chen
Kruppel-like factor 2 controls T cell trafficking by activating L-selectin (CD62L) and sphingosine-1-phosphate receptor 1 transcription.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(12):7632-9.
2007: Mini Thomas; James J Lu; Jianzhu Chen; Alexander M Klibanov
Non-viral siRNA delivery to the lung.
Advanced drug delivery reviews 2007;59(2-3):124-33.
2007: Qibin Leng; Qing Ge; Tam Nguyen; Herman N Eisen; Jianzhu Chen
Stage-dependent reactivity of thymocytes to self-peptide--MHC complexes.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(12):5038-43.
2006: Jayanta Haldar; Deqiang An; Luis Alvarez de Cienfuegos; Jianzhu Chen; Alexander M Klibanov
Polymeric coatings that inactivate both influenza virus and pathogenic bacteria.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(47):17667-71.
2006: Qing Ge; Manoj Pastey; Darwyn Kobasa; Piliapan Puthavathana; Christopher Lupfer; Richard K Bestwick; Patrick L Iversen; Jianzhu Chen; David A Stein
Inhibition of multiple subtypes of influenza A virus in cell cultures with morpholino oligomers.
Antimicrobial agents and chemotherapy 2006;50(11):3724-33.
2006: Brendan Jones; Jianzhu Chen
Inhibition of IFN-gamma transcription by site-specific methylation during T helper cell development.
The EMBO journal 2006;25(11):2443-52.
2006: Brian B Haines; Chun Jeih Ryu; Jianzhu Chen
Recombination activating genes (RAG) in lymphoma development.
Cell cycle (Georgetown, Tex.) 2006;5(9):913-6.
2006: Kenneth J Oestreich; Robin Milley Cobb; Steven Pierce; Jianzhu Chen; Pierre Ferrier; Eugene M Oltz
Regulation of TCRbeta gene assembly by a promoter/enhancer holocomplex.
Immunity 2006;24(4):381-91.
2006: Qing Ge; Phillip D Holler; Vinay S Mahajan; Tam Nuygen; Herman N Eisen; Jianzhu Chen
Development of CD4+ T cells expressing a nominally MHC class I-restricted T cell receptor by two different mechanisms.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(6):1822-7.
2006: Brian B Haines; Chun Jeih Ryu; Sandy Chang; Alexei Protopopov; Andreas Luch; Yun Hee Kang; Dobrin D Draganov; Maria F Fragoso; Sang Gi Paik; Hyo Jeong Hong; Ronald A DePinho; Jianzhu Chen
Block of T cell development in P53-deficient mice accelerates development of lymphomas with characteristic RAG-dependent cytogenetic alterations.
Cancer cell 2006;9(2):109-20.
2006: Musheng Bao; Yi Zhang; Min Wan; Li Dai; Xiaoping Hu; Xiuli Wu; Li Wang; Ping Deng; Junzhi Wang; Jianzhu Chen; Yongjun Liu; Yongli Yu; Liying Wang
Anti-SARS-CoV immunity induced by a novel CpG oligodeoxynucleotide.
Clinical immunology (Orlando, Fla.) 2006;118(2-3):180-7.
2005: Mini Thomas; James J Lu; Qing Ge; Chengcheng Zhang; Jianzhu Chen; Alexander M Klibanov
Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(16):5679-84.
2005: Mini Thomas; Qing Ge; James J Lu; Alexander M Klibanov; Jianzhu Chen
Polycation-mediated delivery of siRNAs for prophylaxis and treatment of influenza virus infection.
Expert opinion on biological therapy 2005;5(4):495-505.
2005: Mini Thomas; Qing Ge; James J Lu; Jianzhu Chen; Alexander M Klibanov
Cross-linked small polyethylenimines: while still nontoxic, deliver DNA efficiently to mammalian cells in vitro and in vivo.
Pharmaceutical research 2005;22(3):373-80.
2004: Chun Jeih Ryu; Brian B Haines; Hye Ran Lee; Yun Hee Kang; Dobrin D Draganov; Minhui Lee; Charles E Whitehurst; Hyo Jeong Hong; Jianzhu Chen
The T-cell receptor beta variable gene promoter is required for efficient V beta rearrangement but not allelic exclusion.
Molecular and cellular biology 2004;24(16):7015-23.
2004: Steven R Little; David M Lynn; Qing Ge; Daniel G Anderson; Sidharth V Puram; Jianzhu Chen; Herman N Eisen; Robert Langer
Poly-beta amino ester-containing microparticles enhance the activity of nonviral genetic vaccines.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(26):9534-9.
2004: Qing Ge; Lily Filip; Ailin Bai; Tam Nguyen; Herman N Eisen; Jianzhu Chen
Inhibition of influenza virus production in virus-infected mice by RNA interference.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(23):8676-81.
2004: Qing Ge; Herman N Eisen; Jianzhu Chen
Use of siRNAs to prevent and treat influenza virus infection.
Virus research 2004;102(1):37-42.
2004: Qing Ge; Ailin Bai; Brendan Jones; Herman N Eisen; Jianzhu Chen
Competition for self-peptide-MHC complexes and cytokines between naive and memory CD8+ T cells expressing the same or different T cell receptors.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):3041-6.
2004: Chun Wang; Qing Ge; David Ting; David Nguyen; Hui-Rong Shen; Jianzhu Chen; Herman N Eisen; Jorge Heller; Robert Langer; David Putnam
Molecularly engineered poly(ortho ester) microspheres for enhanced delivery of DNA vaccines.
Nature materials 2004;3(3):190-6.
2004: Markus G Rudolph; Lucy Q Shen; Stephen A Lamontagne; John G Luz; Joseph R Delaney; Qing Ge; Bryan K Cho; Deborah Palliser; Carol A McKinley; Jianzhu Chen; Ian A Wilson; Herman N Eisen
A peptide that antagonizes TCR-mediated reactions with both syngeneic and allogeneic agonists: functional and structural aspects.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(5):2994-3002.
2004: Victoria E H Wang; Dean Tantin; Jianzhu Chen; Phillip A Sharp
B cell development and immunoglobulin transcription in Oct-1-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(7):2005-10.
2004: Victoria E H Wang; Tara Schmidt; Jianzhu Chen; Phillip A Sharp; Dean Tantin
Embryonic lethality, decreased erythropoiesis, and defective octamer-dependent promoter activation in Oct-1-deficient mice.
Molecular and cellular biology 2004;24(3):1022-32.
2004: Hidefumi Kojima; Brendan T Jones; Jianzhu Chen; Marilia I Cascalho; Michail V Sitkovsky
Hypoxia-inducible factor 1alpha-deficient chimeric mice as a model to study abnormal B lymphocyte development and autoimmunity.
Methods in enzymology 2004;381():218-29.
2003: Chun Jeih Ryu; Brian B Haines; Dobrin D Draganov; Yun Hee Kang; Charles E Whitehurst; Tara Schmidt; Hyo Jeong Hong; Jianzhu Chen
The T cell receptor beta enhancer promotes access and pairing of Dbeta and Jbeta gene segments during V(D)J recombination.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(23):13465-70.
2003: Todd H Rider; Martha S Petrovick; Frances E Nargi; James D Harper; Eric D Schwoebel; Richard H Mathews; David J Blanchard; Laura T Bortolin; Albert M Young; Jianzhu Chen; Mark A Hollis
A B cell-based sensor for rapid identification of pathogens.
Science (New York, N.Y.) 2003;301(5630):213-5.
2003: Qing Ge; Ailin Bai; Ching-Hung Shen; Herman N Eisen; Jianzhu Chen
CD4+ T-cell responses to self-peptide--MHC.
Trends in immunology 2003;24(4):186-9.
2003: Kishore R Alugupalli; Rachel M Gerstein; Jianzhu Chen; Eva Szomolanyi-Tsuda; Robert T Woodland; John M Leong
The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(7):3819-27.
2003: Qing Ge; Michael McManus; Tam Nguyen; Ching-Hung Shen; Phillip A Sharp; Herman N Eisen; Jianzhu Chen
RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2718-23.
2003: Jianzhu Chen; Herman N Eisen; David M Kranz
A model T-cell receptor system for studying memory T-cell development.
Microbes and infection / Institut Pasteur 2003;5(3):233-40.
2002: Michael McManus; Brian B Haines; Christopher P Dillon; Charles E Whitehurst; Luk Van Parijs; Jianzhu Chen; Phillip A Sharp
Small interfering RNA-mediated gene silencing in T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(10):5754-60.
2002: Qing Ge; Jennifer D Stone; M Todd Thompson; Jennifer Cochran; Mia M Rushe; Herman N Eisen; Jianzhu Chen; Lawrence J Stern
Soluble peptide-MHC monomers cause activation of CD8+ T cells through transfer of the peptide to T cell MHC molecules.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(21):13729-34.
2002: Marianne Boes; Jan Cerny; Ramiro Massol; Marjolein Op den Brouw; Tomas Kirchhausen; Jianzhu Chen; Hidde L Ploegh
T-cell engagement of dendritic cells rapidly rearranges MHC class II transport.
Nature 2002;418(6901):983-8.
2002: Michael McManus; Christian P. Petersen; Brian B Haines; Jianzhu Chen; Phillip A Sharp
Gene silencing using micro-RNA designed hairpins.
RNA (New York, N.Y.) 2002;8(6):842-50.
2002: Qing Ge; Hui Hu; Herman N Eisen; Jianzhu Chen
Naïve to memory T-cell differentiation during homeostasis-driven proliferation.
Microbes and infection / Institut Pasteur 2002;4(5):555-8.
2002: Antonio Freitas; Jianzhu Chen
Introduction: regulation of lymphocyte homeostasis.
Microbes and infection / Institut Pasteur 2002;4(5):529-30.
2002: Qing Ge; Hui Hu; Herman N Eisen; Jianzhu Chen
Different contributions of thymopoiesis and homeostasis-driven proliferation to the reconstitution of naive and memory T cell compartments.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):2989-94.
2002: Qing Ge; Deborah Palliser; Herman N Eisen; Jianzhu Chen
Homeostatic T cell proliferation in a T cell-dendritic cell coculture system.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):2983-8.
2002: Jianzhu Chen; Qing Ge; Bryan Cho; Herman N Eise
T cell proliferation, differentiation, and restoration in lymphopenic individuals: for contributed volumes.
Advances in experimental medicine and biology 2002;512():135-9.
2002: Satoshi Sugawa; Deborah Palliser; Herman N Eisen; Jianzhu Chen
How do cultured CD8(+) murine T cell clones survive repeated ligation of the TCR?
International immunology 2002;14(1):23-30.
2002: T Dianne Langford; Michael P Housley; Marianne Boes; Jianzhu Chen; Martin F Kagnoff; Frances D Gillin; Lars Eckmann
Central importance of immunoglobulin A in host defense against Giardia spp.
Infection and immunity 2002;70(1):11-8.
2001: C Esau; Marianne Boes; Hong-Duk Youn; L Tatterson; Jun O Liu; Jianzhu Chen
Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells.
The Journal of experimental medicine 2001;194(10):1449-59.
2001: Daewoong Jo; Abudi Nashabi; C Doxsee; Qing Lin; Derya Unutmaz; Jianzhu Chen; H Earl Ruley
Epigenetic regulation of gene structure and function with a cell-permeable Cre recombinase.
Nature biotechnology 2001;19(10):929-33.
2001: P Sieh; Jianzhu Chen
Distinct control of the frequency and allelic exclusion of the V beta gene rearrangement at the TCR beta locus.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(4):2121-9.
2001: Nikki Cheng; Jianzhu Chen
Tumor necrosis factor-alpha induction of endothelial ephrin A1 expression is mediated by a p38 MAPK- and SAPK/JNK-dependent but nuclear factor-kappa B-independent mechanism.
The Journal of biological chemistry 2001;276(17):13771-7.
2001: Ying Chen; E Rosloniec; Mehmet Goral; Mark Boothby; Jianzhu Chen
Redirection of T cell effector function in vivo and enhanced collagen-induced arthritis mediated by an IL-2R beta/IL-4R alpha chimeric cytokine receptor transgene.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(6):4163-9.
2001: Qing Ge; Varada P Rao; Bryan K Cho; Herman N Eisen; Jianzhu Chen
Dependence of lymphopenia-induced T cell proliferation on the abundance of peptide/ MHC epitopes and strength of their interaction with T cell receptors.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1728-33.
2001: Bryan K Cho; K C Lian; P Lee; A Brunmark; C McKinley; Jianzhu Chen; David M Kranz; Herman N Eisen
Differences in antigen recognition and cytolytic activity of CD8(+) and CD8(-) T cells that express the same antigen-specific receptor.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1723-7.
2001: Charles E Whitehurst; H Hu; Chun Jeih Ryu; P Rajendran; Tara Schmidt; Jianzhu Chen
Normal TCRbeta transcription and recombination in the absence of the Jbeta2-Cbeta2 intronic cis element.
Molecular immunology 2001;38(1):55-63.
2000: Charles E Whitehurst; M S Schlissel; Jianzhu Chen
Deletion of germline promoter PD beta 1 from the TCR beta locus causes hypermethylation that impairs D beta 1 recombination by multiple mechanisms.
Immunity 2000;13(5):703-14.
2000: Bryan K Cho; Varada P Rao; Qing Ge; Herman N Eisen; Jianzhu Chen
Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells.
The Journal of experimental medicine 2000;192(4):549-56.
2000: Bryan K Cho; Deborah Palliser; Eduardo Guillen; J Wisniewski; Richard A Young; Jianzhu Chen; Herman N Eisen
A proposed mechanism for the induction of cytotoxic T lymphocyte production by heat shock fusion proteins.
Immunity 2000;12(3):263-72.
2000: Marianne Boes; Tara Schmidt; K Linkemann; Britte C Beaudette; Ann Marshak-Rothstein; Jianzhu Chen
Accelerated development of IgG autoantibodies and autoimmune disease in the absence of secreted IgM.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(3):1184-9.
2000: Igor I Kuzin; Gregory D Ugine; Dianqing Wu; Faith Young; Jianzhu Chen; Andrea Bottaro
Normal isotype switching in B cells lacking the I mu exon splice donor site: evidence for multiple I mu-like germline transcripts.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(3):1451-7.
1999: Vikram R Rao; M N Corradetti; Jianzhu Chen; Junmin Peng; Junying Yuan; Glenn D Prestwich; Joan S Brugge
Expression cloning of protein targets for 3-phosphorylated phosphoinositides.
The Journal of biological chemistry 1999;274(53):37893-900.
1999: H Kuo; Jianzhu Chen; Pilar Ruiz-Lozano; Y Zou; M Nemer; Kenneth R Chien
Control of segmental expression of the cardiac-restricted ankyrin repeat protein gene by distinct regulatory pathways in murine cardiogenesis.
Development (Cambridge, England) 1999;126(19):4223-34.
1999: R Seetharaman; Ana L Mora; G Nabozny; Mark Boothby; Jianzhu Chen
Essential role of T cell NF-kappa B activation in collagen-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(3):1577-83.
1999: Bryan K Cho; C Wang; S Sugawa; Herman N Eisen; Jianzhu Chen
Functional differences between memory and naive CD8 T cells.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):2976-81.
1999: Charles E Whitehurst; S Chattopadhyay; Jianzhu Chen
Control of V(D)J recombinational accessibility of the D beta 1 gene segment at the TCR beta locus by a germline promoter.
Immunity 1999;10(3):313-22.
1998: Marianne Boes; AP Prodeus; Tara Schmidt; Michael C Carroll; Jianzhu Chen
A critical role of natural immunoglobulin M in immediate defense against systemic bacterial infection.
The Journal of experimental medicine 1998;188(12):2381-6.
1998: Jeehee Youn; Jianzhu Chen; Shreevrat Goenka; Mark A Aronica; Ana L Mora; V Correa; James R Sheller; Mark Boothby
In vivo function of an interleukin 2 receptor beta chain (IL-2Rbeta)/IL-4Ralpha cytokine receptor chimera potentiates allergic airway disease.
The Journal of experimental medicine 1998;188(10):1803-16.
1998: S Chattopadhyay; Charles E Whitehurst; Jianzhu Chen
A nuclear matrix attachment region upstream of the T cell receptor beta gene enhancer binds Cux/CDP and SATB1 and modulates enhancer-dependent reporter gene expression but not endogenous gene expression.
The Journal of biological chemistry 1998;273(45):29838-46.
1998: Jianzhu Chen; H Earl Ruley
An enhancer element in the EphA2 (Eck) gene sufficient for rhombomere-specific expression is activated by HOXA1 and HOXB1 homeobox proteins.
The Journal of biological chemistry 1998;273(38):24670-5.
1998: Andrea Bottaro; Faith Young; Jianzhu Chen; M Serwe; F Sablitzky; Frederick W Alt
Deletion of the IgH intronic enhancer and associated matrix-attachment regions decreases, but does not abolish, class switching at the mu locus.
International immunology 1998;10(6):799-806.
1998: Marianne Boes; C Esau; M B Fischer; Tara Schmidt; M Carroll; Jianzhu Chen
Enhanced B-1 cell development, but impaired IgG antibody responses in mice deficient in secreted IgM.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(10):4776-87.
1998: Jianzhu Chen; Steven W Kubalak; Kenneth R Chien
Ventricular muscle-restricted targeting of the RXRalpha gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis.
Development (Cambridge, England) 1998;125(10):1943-9.
1998: S Chattopadhyay; Charles E Whitehurst; F Schwenk; Jianzhu Chen
Biochemical and functional analyses of chromatin changes at the TCR-beta gene locus during CD4-CD8- to CD4+CD8+ thymocyte differentiation.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(3):1256-67.
1998: Jianzhu Chen; Steven W Kubalak; Susumu Minamisawa; Robert L Price; KD Becker; Reed Hickey; John Ross; Kenneth R Chien
Selective requirement of myosin light chain 2v in embryonic heart function.
The Journal of biological chemistry 1998;273(2):1252-6.
1998: CA Gibson; Jianzhu Chen; S A Monroe; Mark Denison
Expression and processing of nonstructural proteins of the human astroviruses.
Advances in experimental medicine and biology 1998;440():387-91.
1997: Z Sheng; Kirk U Knowlton; Jianzhu Chen; Masahiko Hoshijima; Joan Heller Brown; Kenneth R Chien
Cardiotrophin 1 (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway. Divergence from downstream CT-1 signals for myocardial cell hypertrophy.
The Journal of biological chemistry 1997;272(9):5783-91.
1997: Y Zou; Sylvia Evans; Jianzhu Chen; H C Kuo; R P Harvey; Kenneth R Chien
CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway.
Development (Cambridge, England) 1997;124(4):793-804.
1992: S Lin; W Long; Jianzhu Chen; Nancy Hopkins
Production of germ-line chimeras in zebrafish by cell transplants from genetically pigmented to albino embryos.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(10):4519-23.