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Jianjun Chen

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Zejuan Li; Paul P Liu; Bob Löwenberg; Richard Morgan; Mary Beth Neilly; Haomin Ren; Janet D Rowley; Peter J M Valk; Chong-Zhi Wang; Chun-Su Yuan; Zhiyu Zhang; Ping Chen; Ruud Delwel; Konstanze Döhner; Abdel G Elkahloun; Chunjiang He; Gia-Ming Hong; Hao Huang; Xi Jiang; Rejani B Kunjamma; Yuanyuan Li; Stephen Arnovitz; Lars Bullinger; Jianjun Chen
PBX3 is an important cofactor of HOXA9 in leukemogenesis.
Xi Jiang; Rejani B Kunjamma; Richard A Larson; Michelle M Le Beau; Yuanyuan Li; Zejuan Li; James C Mulloy; Mary Beth Neilly; Colles Price; Haomin Ren; Janet D Rowley; Justin Salat; Robert K Slany; Mark Wunderlich; Yanming Zhang; Ping Chen; Sandeep Gurbuxani; Chunjiang He; Gia-Ming Hong; Hao Huang; Stephen Arnovitz; Jianjun Chen
MiR-495 is a tumor-suppressor microRNA down-regulated in MLL-rearranged leukemia.
Xi Jiang; Jianjun Chen
miR-150:targeting MLL leukemia.

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All Publications

2013: Zejuan Li; Paul P Liu; Bob Löwenberg; Richard Morgan; Mary Beth Neilly; Haomin Ren; Janet D Rowley; Peter J M Valk; Chong-Zhi Wang; Chun-Su Yuan; Zhiyu Zhang; Ping Chen; Ruud Delwel; Konstanze Döhner; Abdel G Elkahloun; Chunjiang He; Gia-Ming Hong; Hao Huang; Xi Jiang; Rejani B Kunjamma; Yuanyuan Li; Stephen Arnovitz; Lars Bullinger; Jianjun Chen
PBX3 is an important cofactor of HOXA9 in leukemogenesis.
Blood 2013;121(8):1422-31.
2012: Xi Jiang; Rejani B Kunjamma; Richard A Larson; Michelle M Le Beau; Yuanyuan Li; Zejuan Li; James C Mulloy; Mary Beth Neilly; Colles Price; Haomin Ren; Janet D Rowley; Justin Salat; Robert K Slany; Mark Wunderlich; Yanming Zhang; Ping Chen; Sandeep Gurbuxani; Chunjiang He; Gia-Ming Hong; Hao Huang; Stephen Arnovitz; Jianjun Chen
MiR-495 is a tumor-suppressor microRNA down-regulated in MLL-rearranged leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(47):19397-402.
2012: Xi Jiang; Jianjun Chen
miR-150:targeting MLL leukemia.
Oncotarget 2012;3(11):1268-9.
2012: Xi Jiang; Rejani B Kunjamma; Richard A Larson; Michelle M Le Beau; Yuanyuan Li; Zejuan Li; Paul P Liu; Jun Lu; Jonathan M Matthews; Mary Beth Neilly; Colles Price; Haomin Ren; Robert K Slany; Jinhua Wang; Xiao Wang; Mengyi Xu; Dewen You; Jiwang Zhang; Shuodan Zhang; Ping Chen; Abdel Elkahloun; Sandeep Gurbuxani; Chuan He; Chunjiang He; Gia-Ming Hong; Hao Huang; Stephen Arnovitz; Jianjun Chen
Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia.
Cancer cell 2012;22(4):524-35.
2012: Miao He; Hao Huang; Yuanyuan Li; Stephen Arnovitz; Jianjun Chen; Ping Chen; Mary Beth Neilly; Janet D Rowley; Minjie Wei; Zejuan Li
Two isoforms of HOXA9 function differently but work synergistically in human MLL-rearranged leukemia.
Blood cells, molecules & diseases 2012;49(2):102-6.
2012: Chunjiang He; Hao Huang; Laurence D Hurst; Zejuan Li; Ping Chen; Jianjun Chen
Young intragenic miRNAs are less coexpressed with host genes than old ones: implications of miRNA-host gene coevolution.
Nucleic acids research 2012;40(9):4002-12.
2012: Zejuan Li; Paul P Liu; Bob Lowenberg; Yves lussier; Kati Maharry; Guido Marcucci; Mary Beth Neilly; Colles Price; Michael D Radmacher; Janet D Rowley; Peter J M Valk; Xinan Yang; Yanming Zhang; Zhiyu Zhang; Ping Chen; Ruud Delwel; Konstanze Dohner; Abdel Elkahloun; Chunjiang He; Miao He; Hao Huang; Xi Jiang; Richard A Larson; Michelle M Le Beau; Yuanyuan Li; Stephen Arnovitz; Clara D Bloomfield; Lars Bullinger; Michael A Caligiuri; Jianjun Chen
Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML.
Blood 2012;119(10):2314-24.
2012: Zejuan Li; Paul P Liu; Bob Lowenberg; Jun Lu; James C Mulloy; Mary Beth Neilly; Chen Shen; Peter J M Valk; James Vardiman; Yungui Wang; Minjie Wei; Mark Wunderlich; Nancy J Zeleznik-Le; Jiwang Zhang; Jun Zhang; Zhiyu Zhang; Ping Chen; Ruud Delwel; Abdel Elkahloun; Chunjiang He; Miao He; Hao Huang; Elizabeth Hyjek; Xi Jiang; Jie Jin; Michelle M Le Beau; Yuanyuan Li; Stephen Arnovitz; Donglin Cao; Jianjun Chen
miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia.
Nature communications 2012;3():688.
2011: Zejuan Li; Jianjun Chen
In vitro functional study of miR-126 in leukemia.
Methods in molecular biology (Clifton, N.J.) 2011;676():185-95.
2010: Shuangli Mi; Zejuan Li; Ping Chen; Chunjiang He; Donglin Cao; Abdel Elkahloun; Jun Lu; Luis A Pelloso; Mark Wunderlich; Hao Huang; Roger T Luo; Miao Sun; Miao He; Mary Beth Neilly; Nancy J Zeleznik-Le; Michael J Thirman; James C Mulloy; Paul P Liu; Janet D Rowley; Jianjun Chen
Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(8):3710-5.
2010: Jianjun Chen; Olatoyosi Odenike; Janet D Rowley
Leukaemogenesis: more than mutant genes.
Nature reviews. Cancer 2010;10(1):23-36.
2009: Zejuan Li; Roger T Luo; Shuangli Mi; Miao Sun; Ping Chen; Jingyue Bao; Mary Beth Neilly; Nimanthi Jayathilaka; Deborah S Johnson; Lili Wang; Catherine Lavau; Yanming Zhang; Charles Tseng; Xiuqing Zhang; Jian Wang; Jun Yu; Huanming Yang; San Ming Wang; Janet D Rowley; Jianjun Chen; Michael J Thirman
Consistent deregulation of gene expression between human and murine MLL rearrangement leukemias.
Cancer research 2009;69(3):1109-16.
2008: Zejuan Li; Jun Lu; Miao Sun; Shuangli Mi; Hao Zhang; Roger T Luo; Ping Chen; Yungui Wang; Ming Yan; Zhijian Qian; Mary Beth Neilly; Jie Jin; Yanming Zhang; Stefan K Bohlander; Dong-Er Zhang; Richard A Larson; Michelle M Le Beau; Michael J Thirman; Todd R Golub; Janet D Rowley; Jianjun Chen
Distinct microRNA expression profiles in acute myeloid leukemia with common translocations.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(40):15535-40.
2007: Shuangli Mi; Jun Lu; Miao Sun; Zejuan Li; Hao Zhang; Mary Beth Neilly; Yungui Wang; Zhijian Qian; Jie Jin; Yanming Zhang; Stefan K Bohlander; Michelle M Le Beau; Richard A Larson; Todd R Golub; Janet D Rowley; Jianjun Chen
MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(50):19971-6.
2007: Wei Wu; Miao Sun; Gang-Ming Zou; Jianjun Chen
MicroRNA and cancer: Current status and prospective.
International journal of cancer. Journal international du cancer 2007;120(5):953-60.
2006: Miao Sun; Laurence D Hurst; Gordon G Carmichael; Jianjun Chen
Evidence for variation in abundance of antisense transcripts between multicellular animals but no relationship between antisense transcriptionand organismic complexity.
Genome research 2006;16(7):922-33.
2006: Sanggyu Lee; Jianjun Chen; Guolin Zhou; Run Zhang Shi; Gerard G Bouffard; Masha Kocherginsky; Xijin Ge; Miao Sun; Nimanthi Jayathilaka; Yeong Cheol Kim; Neelmini Emmanuel; Stefan K Bohlander; Mark Minden; Justin Kline; Ozden Ozer; Richard A Larson; Michelle M LeBeau; Eric Green; Jeffrey M. Trent; Theodore Karrison; Piu Paul Liu; San Ming Wang; Janet D Rowley
Gene expression profiles in acute myeloid leukemia with common translocations using SAGE.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(4):1030-5.
2005: Jianjun Chen; Miao Sun; Laurence D Hurst; Gordon G Carmichael; Janet D Rowley
Genome-wide analysis of coordinate expression and evolution of human cis-encoded sense-antisense transcripts.
Trends in genetics : TIG 2005;21(6):326-9.
2005: Jianjun Chen; Miao Sun; Laurence D Hurst; Gordon G Carmichael; Janet D Rowley
Human antisense genes have unusually short introns: evidence for selection for rapid transcription.
Trends in genetics : TIG 2005;21(4):203-7.
2005: Miao Sun; Laurence D Hurst; Gordon G Carmichael; Jianjun Chen
Evidence for a preferential targeting of 3'-UTRs by cis-encoded natural antisense transcripts.
Nucleic acids research 2005;33(17):5533-43.
2004: Yuri N Kobzev; Jose A Martinez-Climent; Sanggyu Lee; Jianjun Chen; Janet D Rowley
Analysis of translocations that involve the NUP98 gene in patients with 11p15 chromosomal rearrangements.
Genes, chromosomes & cancer 2004;41(4):339-52.
2004: Yanming Zhang; Nancy J Zeleznik-Le; Neelmini Emmanuel; Nimanthi Jayathilaka; Jianjun Chen; Pamela L Strissel; Reiner Strick; Loretta Li; Mary Beth Neilly; Tomohiko Taki; Yasuhide Hayashi; Yasuhiko Kaneko; Brigitte Schlegelberger; Janet D Rowley
Characterization of genomic breakpoints in MLL and CBP in leukemia patients with t(11;16).
Genes, chromosomes & cancer 2004;41(3):257-65.
2004: Yanming Zhang; Neelmini Emmanuel; Ginny Kamboj; Jianjun Chen; Muhammad Shurafa; Daniel L Van Dyke; Anne Wiktor; Janet D Rowley
PRDX4, a member of the peroxiredoxin family, is fused to AML1 (RUNX1) in an acute myeloid leukemia patient with a t(X;21)(p22;q22).
Genes, chromosomes & cancer 2004;40(4):365-70.
2004: Miao Sun; Guolin Zhou; Sanggyu Lee; Jianjun Chen; Run Zhang Shi; San Ming Wang
SAGE is far more sensitive than EST for detecting low-abundance transcripts.
BMC genomics 2004;5(1):1.
2004: Jianjun Chen; Miao Sun; W James Kent; Xiaoqiu Huang; Hanqing Xie; Wenquan Wang; Guolin Zhou; Run Zhang Shi; Janet D Rowley
Over 20% of human transcripts might form sense-antisense pairs.
Nucleic acids research 2004;32(16):4812-20.
2003: Gang-Ming Zou; Wei Wu; Jianjun Chen; Janet D Rowley
Duplexes of 21-nucleotide RNAs mediate RNA interference in differentiated mouse ES cells.
Biology of the cell / under the auspices of the European Cell Biology Organization 2003;95(6):365-71.
2002: Jianjun Chen; Miao Sun; Sanggyu Lee; Guolin Zhou; Janet D Rowley; San Ming Wang
Identifying novel transcripts and novel genes in the human genome by using novel SAGE tags.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(19):12257-62.
2002: Douglas Kyung Nam; Sanggyu Lee; Guolin Zhou; Xiaohong Cao; Clarence Wang; Terry Clark; Jianjun Chen; Janet D Rowley; San Ming Wang
Oligo(dT) primer generates a high frequency of truncated cDNAs through internal poly(A) priming during reverse transcription.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(9):6152-6.
2002: Sanggyu Lee; Terry Clark; Jianjun Chen; Guolin Zhou; L Ridgway Scott; Janet D Rowley; San Ming Wang
Correct identification of genes from serial analysis of gene expression tag sequences.
Genomics 2002;79(4):598-602.
2002: Yanming Zhang; Pamela L Strissel; Reiner Strick; Jianjun Chen; Giuseppina Nucifora; Michelle M Le Beau; Richard A Larson; Janet D Rowley
Genomic DNA breakpoints in AML1/RUNX1 and ETO cluster with topoisomerase II DNA cleavage and DNase I hypersensitive sites in t(8;21) leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):3070-5.
2002: Jianjun Chen; Sanggyu Lee; Guolin Zhou; San Ming Wang
High-throughput GLGI procedure for converting a large number of serial analysis of gene expression tag sequences into 3' complementary DNAs.
Genes, chromosomes & cancer 2002;33(3):252-61.
2001: Guolin Zhou; Jianjun Chen; Sanggyu Lee; Terry Clark; Janet D Rowley; San Ming Wang
The pattern of gene expression in human CD34(+) stem/progenitor cells.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13966-71.
2001: Jianjun Chen; Donald A Rowley; Terry Clark; Sanggyu Lee; Guolin Zhou; C Beck; Janet D Rowley; San Ming Wang
The pattern of gene expression in mouse Gr-1(+) myeloid progenitor cells.
Genomics 2001;77(3):149-62.
2001: Sanggyu Lee; Guolin Zhou; Terry Clark; Jianjun Chen; Janet D Rowley; San Ming Wang
The pattern of gene expression in human CD15+ myeloid progenitor cells.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3340-5.