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Jiang-Fan Chen

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Shuang-Shuang Dai; Wei Li; Ya-Lei Ning; Hao Wang; Nan Yang; Jian-Hong An; Jiang-Fan Chen; Pei-fang Zhu; Yuan-Guo Zhou
Plasma glutamate-modulated interaction of A2AR and mGluR5 on BMDCs aggravates traumatic brain injury-induced acute lung injury.
Jiang-Fan Chen; Holger K Eltzschig; Bertil B. Fredholm
Adenosine receptors as drug targets--what are the challenges?
Philipp Singer; Catherine J Wei; Detlev Boison; Jiang-Fan Chen; Benjamin K Yee
Deletion of striatal adenosine A(2A) receptor spares latent inhibition and prepulse inhibition but impairs active avoidance learning.

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All Publications

2013: Shuang-Shuang Dai; Wei Li; Ya-Lei Ning; Hao Wang; Nan Yang; Jian-Hong An; Jiang-Fan Chen; Pei-fang Zhu; Yuan-Guo Zhou
Plasma glutamate-modulated interaction of A2AR and mGluR5 on BMDCs aggravates traumatic brain injury-induced acute lung injury.
The Journal of experimental medicine 2013;210(4):839-51.
2013: Jiang-Fan Chen; Holger K Eltzschig; Bertil B. Fredholm
Adenosine receptors as drug targets--what are the challenges?
Nature reviews. Drug discovery 2013;12(4):265-86.
2013: Philipp Singer; Catherine J Wei; Detlev Boison; Jiang-Fan Chen; Benjamin K Yee
Deletion of striatal adenosine A(2A) receptor spares latent inhibition and prepulse inhibition but impairs active avoidance learning.
Behavioural brain research 2013;242():54-61.
2013: Anne-Marie A Wills; Jiang-Fan Chen; Shirley Eberly; Cornelia Kamp; Anthony E Lang; Michael P McDermott; Susan Messing; David Oakes; Michael A Schwarzschild; Caroline M Tanner; Marsha Tennis; Daniel Togasaki
Caffeine consumption and risk of dyskinesia in CALM-PD.
Movement disorders : official journal of the Movement Disorder Society 2013;28(3):380-3.
2013: Q Lian; H Lin; K Lu; L Tang; B Wang; L Xu; F Zhang; W Zhou; H Zhu; Q Huang; S Jin; M Lai; J Li; H Cao; Jiang-Fan Chen; R-S Ge
Self-administration of propofol is mediated by dopamine D1 receptors in nucleus accumbens in rats.
Neuroscience 2013;231():373-83.
2012: Michael Lazarus; Jun Lu; Yoshihiro Urade; Zhi-Li Huang; Jiang-Fan Chen
How do the basal ganglia regulate sleep-wake behavior?
Trends in neurosciences 2012;35(12):723-32.
2012: Shu-Qin Yao; Elisabete Augusto; Jiang-Fan Chen; Jin-Cai He; Qing-Yuan Huang; Fang Li; Zheng-Zheng Li; Xiao-Tong Wang; Zhao-Wei Wang; Rong-yuan Zheng
Genetic inactivation of the adenosine A(2A) receptor exacerbates brain damage in mice with experimental autoimmune encephalomyelitis.
Journal of neurochemistry 2012;123(1):100-12.
2012: Hai-Ying Shen; Philipp Singer; Catherine J Wei; Rebecca L Williams-Karnesky; Benjamin K Yee; Jiang-Fan Chen; Jing-Quan Lan; Nikki Lytle; Detlev Boison
Adenosine augmentation ameliorates psychotic and cognitive endophenotypes of schizophrenia.
The Journal of clinical investigation 2012;122(7):2567-77.
2012: Jeffrey H Mills; Jiang-Fan Chen; Do-Geun Kim; Antje Krenz; Margaret S Bynoe
A2A adenosine receptor signaling in lymphocytes and the central nervous system regulates inflammation during experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(11):5713-22.
2012: Marco Matos; Alexandre Dos Santos-Rodrigues; Michael A Schwarzschild; Elisabete Augusto; Jiang-Fan Chen; Rodrigo A Cunha; Paula M.G. Agostinho
Adenosine A2A receptors modulate glutamate uptake in cultured astrocytes and gliosomes.
Glia 2012;60(5):702-16.
2012: Hennady P Shulha; Jogender S Tushir; Zhiping Weng; Wei-Dong Yao; Rahul Bharadwaj; Jiang-Fan Chen; Iris Cheung; Hsin-Jung Chou; Jessica L Crisci; Isaac B Houston; Jeffrey D Jensen; Amanda C Mitchell; Richard H Myers; Cyril J Peter; Todd M Preuss; Denis Reshetov; Evgeny I Rogaev; Schahram Akbarian
Human-specific histone methylation signatures at transcription start sites in prefrontal neurons.
PLoS biology 2012;10(11):e1001427.
2011: Gabriela E Garcia; Richard J Johnson; Luan D Truong; Jiang-Fan Chen; Lili Feng
Adenosine A(2A) receptor activation prevents progressive kidney fibrosis in a model of immune-associated chronic inflammation.
Kidney international 2011;80(4):378-88.
2011: Michael Lazarus; Wei-Min Qu; Kazue Semba; Hai-Ying Shen; Yoshihiro Urade; Raphaëlle Winsky-Sommerer; Yoan Cherasse; Bertil B Fredholm; Osamu Hayaishi; Zhi-Li Huang; Caroline E Bass; Detlev Boison; Jiang-Fan Chen
Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(27):10067-75.
2011: Catherine J Wei; Wei Li; Jiang-Fan Chen
Normal and abnormal functions of adenosine receptors in the central nervous system revealed by genetic knockout studies.
Biochimica et biophysica acta 2011;1808(5):1358-79.
2011: Danqing Xiao; Jared J Cassin; Brian Healy; Thomas C Burdett; Jiang-Fan Chen; Bertil B Fredholm; Michael A Schwarzschild
Deletion of adenosine A₁ or A(₂A) receptors reduces L-3,4-dihydroxyphenylalanine-induced dyskinesia in a model of Parkinson's disease.
Brain research 2011;1367():310-8.
2011: Feng Dong; Runxia Lu; Xinjie Mao; Miaozhen Pan; Xiaoyi Qin; Jia Qu; Mark D P Willcox; Ruozhong Xie; Zhina Zhi; Jiang-Fan Chen; Xiangtian Zhou
Inhibition of experimental myopia by a dopamine agonist: different effectiveness between form deprivation and hyperopic defocus in guinea pigs.
Molecular vision 2011;17():2824-34.
2011: Nai-Kuei Huang; Hsing-Lin Lai; Chia-I Lin; Chun-Jung Lin; Jung-Hsin Lin; Jiun-Tsai Lin; Yun-Lian Lin; Eric Minwei Liu; Yuh-Chiang Shen; Yu-Shuo Wu; Chieh-Wen Yang; Chen Chang; Hui-Mei Chen; Jhih-Bin Chen; Jiang-Fan Chen; Wan-Ping Chen; Ming-Chang Chiang; Jim-Min Fang; Yijuang Chern
A new drug design targeting the adenosinergic system for Huntington's disease.
PloS one 2011;6(6):e20934.
2011: Catherine J Wei; Benjamin K Yee; Detlev Boison; Joana Coelho; Joram Feldon; Philipp Singer; Jiang-Fan Chen
Selective inactivation of adenosine A(2A) receptors in striatal neurons enhances working memory and reversal learning.
Learning & memory (Cold Spring Harbor, N.Y.) 2011;18(7):459-74.
2011: M H Xu; Y S Gong; M S Su; Z Y Dai; S S Dai; S Z Bao; N Li; Rong-yuan Zheng; J C He; Jiang-Fan Chen; X T Wang
Absence of the adenosine A2A receptor confers pulmonary arterial hypertension and increased pulmonary vascular remodeling in mice.
Journal of vascular research 2011;48(2):171-83.
2011: Jiang-Fan Chen; Yijuang Chern
Impacts of methylxanthines and adenosine receptors on neurodegeneration: human and experimental studies.
Handbook of experimental pharmacology 2011;(200):267-310.
2010: Xiao-Ling Liu; Rong Zhou; Qi-Qi Pan; Xiao-Lin Jia; Wei-Na Gao; Jun Wu; Jing Lin; Jiang-Fan Chen
Genetic inactivation of the adenosine A2A receptor attenuates pathologic but not developmental angiogenesis in the mouse retina.
Investigative ophthalmology & visual science 2010;51(12):6625-32.
2010: Fatima A Sehba; Rowena Flores; Artur Muller; Victor L Friedrich; Jiang-Fan Chen; Gavin W Britz; H Winn; Joshua B Bederson
Adenosine A(2A) receptors in early ischemic vascular injury after subarachnoid hemorrhage. Laboratory investigation.
Journal of neurosurgery 2010;113(4):826-34.
2010: Jessica E Sturgess; Ryan A Ting-A-Kee; Dominik Podbielski; Laurie Sellings; Jiang-Fan Chen; Derek van der Kooy
Adenosine A1 and A2A receptors are not upstream of caffeine's dopamine D2 receptor-dependent aversive effects and dopamine-independent rewarding effects.
The European journal of neuroscience 2010;32(1):143-54.
2010: Nanna Goldman; Michael Chen; Takumi Fujita; Qiwu Xu; Weiguo Peng; Wei Liu; Tina K Jensen; Yong Pei; Fushun Wang; Xiaoning Han; Jiang-Fan Chen; Jurgen Schnermann; Takahiro Takano; Lane Bekar; Kim Tieu; Maiken Nedergaard
Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture.
Nature neuroscience 2010;13(7):883-8.
2010: Shuang-Shuang Dai; Wei Li; Jian-Hong An; Hao Wang; Nan Yang; Xing-Yun Chen; Yan Zhao; Ping Li; Ping Liu; Jiang-Fan Chen; Yuan-Guo Zhou
Adenosine A2A receptors in both bone marrow cells and non-bone marrow cells contribute to traumatic brain injury.
Journal of neurochemistry 2010;113(6):1536-44.
2010: K Xu; Yue-Hang Xu; Jiang-Fan Chen; Michael A Schwarzschild
Neuroprotection by caffeine: time course and role of its metabolites in the MPTP model of Parkinson's disease.
Neuroscience 2010;167(2):475-81.
2010: Ailian Yang; Ashley D Mucsi; Melanie D Desrosiers; Jiang-Fan Chen; Jürgen B Schnermann; Michael R Blackburn; Yan Shi
Adenosine mediated desensitization of cAMP signaling enhances T-cell responses.
European journal of immunology 2010;40(2):449-59.
2010: Hai-Ying Shen; Yan Zhao; Xing-Yun Chen; Ren-Ping Xiong; Jin-Li Lu; Jiang-Fan Chen; Li-Yong Chen; Yuan-Guo Zhou
Differential alteration of heat shock protein 90 in mice modifies glucocorticoid receptor function and susceptibility to trauma.
Journal of neurotrauma 2010;27(2):373-81.
2010: Guo Qian Chen; Yan Yan Chen; Xin Shi Wang; Shu-zhen Wu; Hui Min Yang; Hui Qin Xu; Jin Cai He; Xiao Tong Wang; Jiang-Fan Chen; Rong-yuan Zheng
Chronic caffeine treatment attenuates experimental autoimmune encephalomyelitis induced by guinea pig spinal cord homogenates in Wistar rats.
Brain research 2010;1309():116-25.
2010: Jiang-Fan Chen; Liqun Yu; Hai-Ying Shen; Jin-Cai He; Xiaotong Wang; Rongyuan Zheng
What knock-out animals tell us about the effects of caffeine.
Journal of Alzheimer's disease : JAD 2010;20 Suppl 1():S17-24.
2009: Sai-Jun Zhou; Mei-Er Zhu; Dan Shu; Xun-Ping Du; Xiu-Hua Song; Xiao-Tong Wang; Rong-yuan Zheng; Xiao-Hong Cai; Jiang-Fan Chen; Jin-Cai He
Preferential enhancement of working memory in mice lacking adenosine A(2A) receptors.
Brain research 2009;1303():74-83.
2009: Chunxiu Yu; Jay Gupta; Jiang-Fan Chen; Henry H Yin
Genetic deletion of A2A adenosine receptors in the striatum selectively impairs habit formation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(48):15100-3.
2009: Li Gui; Wei Duan; Hong Tian; Chuanming Li; Jie Zhu; Jiang-Fan Chen; Jian Zheng
Adenosine A 2A receptor deficiency reduces striatal glutamate outflow and attenuates brain injury induced by transient focal cerebral ischemia in mice.
Brain research 2009;1297():185-93.
2009: Wei Duan; Li Gui; Zhujuan Zhou; Yong Liu; Hong Tian; Jiang-Fan Chen; Jian Zheng
Adenosine A2A receptor deficiency exacerbates white matter lesions and cognitive deficits induced by chronic cerebral hypoperfusion in mice.
Journal of the neurological sciences 2009;285(1-2):39-45.
2009: Anti Kalda; Laura Herm; Ago Rinken; Alexander Zharkovsky; Jiang-Fan Chen
Co-administration of the partial dopamine D2 agonist terguride with L-dopa attenuates L-dopa-induced locomotor sensitization in hemiparkinsonian mice.
Behavioural brain research 2009;202(2):232-7.
2009: Hai-Ying Shen; Jiang-Fan Chen
Adenosine A(2A) receptors in psychopharmacology: modulators of behavior, mood and cognition.
Current neuropharmacology 2009;7(3):195-206.
2009: Maria Teresa Tebano; Alberto Martire; Valentina Chiodi; Rita Pepponi; Antonella Ferrante; Maria Rosaria Domenici; Claudio Frank; Jiang-Fan Chen; Catherine Ledent; Patrizia Popoli
Adenosine A2A receptors enable the synaptic effects of cannabinoid CB1 receptors in the rodent striatum.
Journal of neurochemistry 2009;110(6):1921-30.
2009: Huan Wang; Weiyu Zhang; Chuhong Zhu; christoph bucher; Bruce R Blazar; Chunxiang Zhang; Jiang-Fan Chen; Joel Linden; Chaodong Wu; Yuqing Huo
Inactivation of the adenosine A2A receptor protects apolipoprotein E-deficient mice from atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(7):1046-52.
2009: Liqun Yu; Joana E Coelho; Xiaoling Zhang; Yutao Fu; Abigail Tillman; Ulas Karaoz; Bertil B. Fredholm; Zhiping Weng; Jiang-Fan Chen
Uncovering multiple molecular targets for caffeine using a drug target validation strategy combining A 2A receptor knockout mice with microarray profiling.
Physiological genomics 2009;37(3):199-210.
2009: Gary K Yang; Jiang-Fan Chen; Timothy J Kieffer; Yin Nam Kwok
Regulation of somatostatin release by adenosine in the mouse stomach.
The Journal of pharmacology and experimental therapeutics 2009;329(2):729-37.
2009: Grzegorz Miekisiak; Kristen Yoo; Adam L Sandler; Tobias B Kulik; Jiang-Fan Chen; H Winn
The role of adenosine in hypercarbic hyperemia: in vivo and in vitro studies in adenosine 2(A) receptor knockout and wild-type mice.
Journal of neurosurgery 2009;110(5):981-8.
2009: Jiang-Ning Yang; Jiang-Fan Chen; Bertil B. Fredholm
Physiological roles of A1 and A2A adenosine receptors in regulating heart rate, body temperature, and locomotion as revealed using knockout mice and caffeine.
American journal of physiology. Heart and circulatory physiology 2009;296(4):H1141-9.
2009: Xin-Shi Wang; Yan-Yan Chen; Xiao-Feng Shang; Zhen-Guo Zhu; Guo-Qian Chen; Zhao Han; Bei Shao; Hui-Min Yang; Hui-Qin Xu; Jiang-Fan Chen; Rong-yuan Zheng
Idazoxan attenuates spinal cord injury by enhanced astrocytic activation and reduced microglial activation in rat experimental autoimmune encephalomyelitis.
Brain research 2009;1253():198-209.
2009: Jiang-Ning Yang; Olga Björklund; Karin Lindström-Törnqvist; Eva Lindgren; Therese M Eriksson; Johan Kahlström; Jiang-Fan Chen; Michael A Schwarzschild; Irene Tobler; Bertil B. Fredholm
Mice heterozygous for both A1 and A(2A) adenosine receptor genes show similarities to mice given long-term caffeine.
Journal of applied physiology (Bethesda, Md. : 1985) 2009;106(2):631-9.
2009: Jacobus P Petzer; Neal Castagnoli; Michael A Schwarzschild; Jiang-Fan Chen; Cornelis J Van Der Schyf
Dual-target-directed drugs that block monoamine oxidase B and adenosine A(2A) receptors for Parkinson's disease.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2009;6(1):141-51.
2008: Hai-Ying Shen; Anti Kalda; Liqun Yu; J Ferrara; J Zhu; Jiang-Fan Chen
Additive effects of histone deacetylase inhibitors and amphetamine on histone H4 acetylation, cAMP responsive element binding protein phosphorylation and DeltaFosB expression in the striatum and locomotor sensitization in mice.
Neuroscience 2008;157(3):644-55.
2008: Greg Miekisiak; Tobias Kulik; Yoshikazu Kusano; David Kung; Jiang-Fan Chen; H Winn
Cerebral blood flow response in adenosine 2a receptor knockout mice during transient hypoxic hypoxia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(10):1656-64.
2008: Eugene I Tikh; Richard A Fenton; Jiang-Fan Chen; Michael A Schwarzschild; James G Dobson
Adenosine A1 and A2A receptor regulation of protein phosphatase 2A in the murine heart.
Journal of cellular physiology 2008;216(1):83-90.
2008: Hai-Ying Shen; Joana E Coelho; Nobuhisa Ohtsuka; Paula Canas; Yuan-Ji Day; Qing-Yuan Huang; Nelson Rebola; Liqun Yu; Detlev Boison; Rodrigo A Cunha; Joel Linden; Joseph Zhuo Tsien; Jiang-Fan Chen
A critical role of the adenosine A2A receptor in extrastriatal neurons in modulating psychomotor activity as revealed by opposite phenotypes of striatum and forebrain A2A receptor knock-outs.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(12):2970-5.
2008: Liqun Yu; Hai-Ying Shen; Joana E Coelho; Inês M Araújo; Qing-Yuan Huang; Yuan-Ji Day; Nelson Rebola; Paula Canas; Erica Kirsten Rapp; Jarrod Ferrara; Darcie Taylor; Christa E Müller; Joel Linden; Rodrigo A Cunha; Jiang-Fan Chen
Adenosine A2A receptor antagonists exert motor and neuroprotective effects by distinct cellular mechanisms.
Annals of neurology 2008;63(3):338-46.
2008: Gabriela E Garcia; Luan D Truong; Ping Li; Ping Zhang; Jie Du; Jiang-Fan Chen; Lili Feng
Adenosine A2A receptor activation and macrophage-mediated experimental glomerulonephritis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(2):445-54.
2008: Rodrigo A Cunha; Sergi Ferré; Jean-Marie Vaugeois; Jiang-Fan Chen
Potential therapeutic interest of adenosine A2A receptors in psychiatric disorders.
Current pharmaceutical design 2008;14(15):1512-24.
2008: Jiang-Fan Chen; Felicita Pedata
Modulation of ischemic brain injury and neuroinflammation by adenosine A2A receptors.
Current pharmaceutical design 2008;14(15):1490-9.
2007: Feng Dong; Jian-hong An; Yue-ping Ren; Dong-sheng Yan; Xing-tao Zhou; Fan Lü; Dan-Ning Hu; Jiang-Fan Chen; Jia Qu
[Expression of dopamine receptor D2 and adenosine receptor A2A in human retinal pigment epithelium].
[Zhonghua yan ke za zhi] Chinese journal of ophthalmology 2007;43(12):1110-3.
2007: Jiang-Fan Chen; Patricia K Sonsalla; Felicita Pedata; Alessia Melani; Maria Rosaria Domenici; Patrizia Popoli; Jonathan Geiger; luisa lopes; Alexandre de Mendonça
Adenosine A2A receptors and brain injury: broad spectrum of neuroprotection, multifaceted actions and "fine tuning" modulation.
Progress in neurobiology 2007;83(5):310-31.
2007: Benjamin Yee; Philipp Singer; Jiang-Fan Chen; Joram Feldon; Detlev Boison
Transgenic overexpression of adenosine kinase in brain leads to multiple learning impairments and altered sensitivity to psychomimetic drugs.
The European journal of neuroscience 2007;26(11):3237-52.
2007: Olga Björklund; Johan Kahlström; Peter Salmi; Sven Ove Ogren; Marie Vahter; Jiang-Fan Chen; Bertil B. Fredholm; Elisabetta Daré
The effects of methylmercury on motor activity are sex- and age-dependent, and modulated by genetic deletion of adenosine receptors and caffeine administration.
Toxicology 2007;241(3):119-33.
2007: Amir Mohsenin; Tiejuan Mi; Yang Xia; Rodney E Kellems; Jiang-Fan Chen; Michael R Blackburn
Genetic removal of the A2A adenosine receptor enhances pulmonary inflammation, mucin production, and angiogenesis in adenosine deaminase-deficient mice.
American journal of physiology. Lung cellular and molecular physiology 2007;293(3):L753-61.
2007: Anti Kalda; Lenne-Triin Heidmets; Hai-Ying Shen; Alexander Zharkovsky; Jiang-Fan Chen
Histone deacetylase inhibitors modulates the induction and expression of amphetamine-induced behavioral sensitization partially through an associated learning of the environment in mice.
Behavioural brain research 2007;181(1):76-84.
2007: Silvia Deaglio; Karen M Dwyer; Keiichii Enjyoji; Anna Erat; David Friedman; Wenda Gao; Vijay K Kuchroo; Joel Linden; Mohamed Oukka; Terry B Strom; Anny Usheva; Jiang-Fan Chen; Simon C Robson
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression.
The Journal of experimental medicine 2007;204(6):1257-65.
2007: Qing-Yuan Huang; Liqun Yu; Robert J Ferrante; Jiang-Fan Chen
Mutant SOD1G93A in bone marrow-derived cells exacerbates 3-nitropropionic acid induced striatal damage in mice.
Neuroscience letters 2007;418(2):175-80.
2007: Arvand Haschemi; Rodrig Marculescu; Simon C Robson; Oswald Wagner; Barbara Wegiel; Fritz H Bach; Jiang-Fan Chen; Nicola Gagliani; David Gallo; Leo E Otterbein
Cross-regulation of carbon monoxide and the adenosine A2a receptor in macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(9):5921-9.
2006: Danqing Xiao; Elena Bastia; Yue-Hang Xu; Caroline L Benn; Jang-Ho Cha; Tracy S Peterson; Jiang-Fan Chen; Michael A Schwarzschild
Forebrain adenosine A2A receptors contribute to L-3,4-dihydroxyphenylalanine-induced dyskinesia in hemiparkinsonian mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(52):13548-55.
2006: Qing-Yuan Huang; Catherine Wei; Liqun Yu; Joana E Coelho; Hai-Ying Shen; Anti Kalda; Joel Linden; Jiang-Fan Chen
Adenosine A2A receptors in bone marrow-derived cells but not in forebrain neurons are important contributors to 3-nitropropionic acid-induced striatal damage as revealed by cell-type-selective inactivation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(44):11371-8.
2006: Michael A Schwarzschild; Luigi F Agnati; Kjell Fuxe; Jiang-Fan Chen; Micaela Morelli
Targeting adenosine A2A receptors in Parkinson's disease.
Trends in neurosciences 2006;29(11):647-54.
2006: Anti Kalda; Liqun Yu; Emin Oztas; Jiang-Fan Chen
Novel neuroprotection by caffeine and adenosine A(2A) receptor antagonists in animal models of Parkinson's disease.
Journal of the neurological sciences 2006;248(1-2):9-15.
2006: H Thomas Lee; Mihwa Kim; Jin Deok Joo; George Gallos; Jiang-Fan Chen; Charles W Emala
A3 adenosine receptor activation decreases mortality and renal and hepatic injury in murine septic peritonitis.
American journal of physiology. Regulatory, integrative and comparative physiology 2006;291(4):R959-69.
2006: Philip Seeman; Johannes Schwarz; Jiang-Fan Chen; Henry Szechtman; Melissa Perreault; G Stanley McKnight; John C Roder; Rémi Quirion; Patricia Boksa; Lalit K Srivastava; Kazuhiko Yanai; David Weinshenker; Tomiki Sumiyoshi
Psychosis pathways converge via D2high dopamine receptors.
Synapse (New York, N.Y.) 2006;60(4):319-46.
2006: Akio Ohta; Elieser Gorelik; Simon J Prasad; franca ronchese; Dmitriy Lukashev; Michael K K Wong; Xiaojun Huang; Sheila Caldwell; Kebin Liu; Patrick Smith; Jiang-Fan Chen; Edwin K Jackson; Sergey Apasov; Scott Abrams; Michail V Sitkovsky
A2A adenosine receptor protects tumors from antitumor T cells.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(35):13132-7.
2006: Edwin S L Chan; Patricia Fernandez; A A Merchant; M Carmen Montesinos; S Trzaska; Avani Desai; C F Tung; D N Khoa; Michael H Pillinger; Allison B Reiss; Marjana Tomic; Jiang-Fan Chen; Michael A Schwarzschild; Bruce N Cronstein
Adenosine A2A receptors in diffuse dermal fibrosis: pathogenic role in human dermal fibroblasts and in a murine model of scleroderma.
Arthritis and rheumatism 2006;54(8):2632-42.
2006: Edwin S L Chan; M Carmen Montesinos; Patricia Fernandez; Avani Desai; David L Delano; Herman Yee; Allison B Reiss; Michael H Pillinger; Jiang-Fan Chen; Michael A Schwarzschild; Scott L Friedman; Bruce N Cronstein
Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis.
British journal of pharmacology 2006;148(8):1144-55.
2006: Ainhoa Bilbao; Andrea Cippitelli; Ana B Martín; Noelia Granado; Oskar Ortiz; Erwan Bezard; Jiang-Fan Chen; Miguel Navarro; Fernando Rodríguez de Fonseca; Rosario Moratalla
Absence of quasi-morphine withdrawal syndrome in adenosine A2A receptor knockout mice.
Psychopharmacology 2006;185(2):160-8.
2006: Liqun Yu; Michael A Schwarzschild; Jiang-Fan Chen
Cross-sensitization between caffeine- and L-dopa-induced behaviors in hemiparkinsonian mice.
Neuroscience letters 2006;393(1):31-5.
2006: Kui Xu; Yuehang Xu; Deborah Brown-Jermyn; Jiang-Fan Chen; Alberto Ascherio; Dean E Dluzen; Michael A Schwarzschild
Estrogen prevents neuroprotection by caffeine in the mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(2):535-41.
2005: Hai-Ying Shen; Jin-Cai He; Yumei Wang; Qing-Yuan Huang; Jiang-Fan Chen
Geldanamycin induces heat shock protein 70 and protects against MPTP-induced dopaminergic neurotoxicity in mice.
The Journal of biological chemistry 2005;280(48):39962-9.
2005: Anil Kachroo; Lianna R Orlando; David K Grandy; Jiang-Fan Chen; Anne B Young; Michael A Schwarzschild
Interactions between metabotropic glutamate 5 and adenosine A2A receptors in normal and parkinsonian mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(45):10414-9.
2005: Josep Saura; Ester Angulo; Aroa Ejarque-Ortiz; Vicent Casadó; Josep M Tusell; Rosario Moratalla; Jiang-Fan Chen; Michael A Schwarzschild; Carmen Lluis; Rafael Franco; Joan Serratosa
Adenosine A2A receptor stimulation potentiates nitric oxide release by activated microglia.
Journal of neurochemistry 2005;95(4):919-29.
2005: Liqun Yu; Peter M Haverty; Juliana Mariani; Yumei Wang; Hai-Ying Shen; Michael A Schwarzschild; Zhiping Weng; Jiang-Fan Chen
Genetic and pharmacological inactivation of adenosine A2A receptor reveals an Egr-2-mediated transcriptional regulatory network in the mouse striatum.
Physiological genomics 2005;23(1):89-102.
2005: Zhi-Li Huang; Wei-Min Qu; Naomi Eguchi; Jiang-Fan Chen; Michael A Schwarzschild; Bertil B. Fredholm; Yoshihiro Urade; Osamu Hayaishi
Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine.
Nature neuroscience 2005;8(7):858-9.
2005: Elena Bastia; Yue-Hang Xu; Angela C Scibelli; Yuan-Ji Day; Joel Linden; Jiang-Fan Chen; Michael A Schwarzschild
A crucial role for forebrain adenosine A(2A) receptors in amphetamine sensitization.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2005;30(5):891-900.
2005: Bertil B. Fredholm; Jiang-Fan Chen; Susan A Masino; Jean-Marie Vaugeois
Actions of adenosine at its receptors in the CNS: insights from knockouts and drugs.
Annual review of pharmacology and toxicology 2005;45():385-412.
2005: Bertil B. Fredholm; Jiang-Fan Chen; Rodrigo A Cunha; Per Svenningsson; Jean-Marie Vaugeois
Adenosine and brain function.
International review of neurobiology 2005;63():191-270.
2005: Ron Yaar; Matthew R Jones; Jiang-Fan Chen; Katya Ravid
Animal models for the study of adenosine receptor function.
Journal of cellular physiology 2005;202(1):9-20.
2004: Liqun Yu; Zhihong Huang; Juliana Mariani; Yumei Wang; Michael Moskowitz; Jiang-Fan Chen
Selective inactivation or reconstitution of adenosine A2A receptors in bone marrow cells reveals their significant contribution to the development of ischemic brain injury.
Nature medicine 2004;10(10):1081-7.
2004: Dmitriy Lukashev; Akio Ohta; Sergey Apasov; Jiang-Fan Chen; Michail V Sitkovsky
Cutting edge: Physiologic attenuation of proinflammatory transcription by the Gs protein-coupled A2A adenosine receptor in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(1):21-4.
2004: Liqun Yu; Martin C Frith; Yutaka Suzuki; Robert A Peterfreund; Tom Gearan; Sumio Sugano; Michael A Schwarzschild; Zhiping Weng; J Stephen Fink; Jiang-Fan Chen
Characterization of genomic organization of the adenosine A2A receptor gene by molecular and bioinformatics analyses.
Brain research 2004;1000(1-2):156-73.
2004: Beth Stevens; Tomoko Ishibashi; Jiang-Fan Chen; R Douglas Fields
Adenosine: an activity-dependent axonal signal regulating MAP kinase and proliferation in developing Schwann cells.
Neuron glia biology 2004;1(1):23-34.
2004: J Stephen Fink; Anti Kalda; Hoon Ryu; Edward C Stack; Michael A Schwarzschild; Jiang-Fan Chen; Robert J Ferrante
Genetic and pharmacological inactivation of the adenosine A2A receptor attenuates 3-nitropropionic acid-induced striatal damage.
Journal of neurochemistry 2004;88(3):538-44.
2004: Martin C Frith; Yutao Fu; Liqun Yu; Jiang-Fan Chen; Ulla Hansen; Zhiping Weng
Detection of functional DNA motifs via statistical over-representation.
Nucleic acids research 2004;32(4):1372-81.
2003: Yoshihiro Urade; Naomi Eguchi; Wei-Min Qu; Mie Sakata; Zhi-Li Huang; Jiang-Fan Chen; Michael A Schwarzschild; J Stephen Fink; Osamu Hayaishi
Sleep regulation in adenosine A2A receptor-deficient mice.
Neurology 2003;61(11 Suppl 6):S94-6.
2003: Jiang-Fan Chen; Silva Fredduzzi; Elena Bastia; Liqun Yu; Rosario Moratalla; Ennio Ongini; Michael A Schwarzschild
Adenosine A2A receptors in neuroadaptation to repeated dopaminergic stimulation: implications for the treatment of dyskinesias in Parkinson's disease.
Neurology 2003;61(11 Suppl 6):S74-81.
2003: Neal Castagnoli; Jacobus P Petzer; Salome Steyn; Kay Castagnoli; Jiang-Fan Chen; Michael A Schwarzschild; Cornelis J Van Der Schyf
Monoamine oxidase B inhibition and neuroprotection: studies on selective adenosine A2A receptor antagonists.
Neurology 2003;61(11 Suppl 6):S62-8.
2003: Michael A Schwarzschild; Kui Xu; Emin Oztas; Jacobus P Petzer; Kay Castagnoli; Neal Castagnoli; Jiang-Fan Chen
Neuroprotection by caffeine and more specific A2A receptor antagonists in animal models of Parkinson's disease.
Neurology 2003;61(11 Suppl 6):S55-61.
2003: Jiang-Fan Chen
The adenosine A(2A) receptor as an attractive target for Parkinson's disease treatment.
Drug news & perspectives 2003;16(9):597-604.
2003: Francesco Bibbiani; Justin D Oh; Jacobus P Petzer; Neal Castagnoli; Jiang-Fan Chen; Michael A Schwarzschild; Thomas N Chase
A2A antagonist prevents dopamine agonist-induced motor complications in animal models of Parkinson's disease.
Experimental neurology 2003;184(1):285-94.
2003: Yuan-Ji Day; Liping Huang; Marcia McDuffie; Diane L Rosin; Hong Ye; Jiang-Fan Chen; Michael A Schwarzschild; J Stephen Fink; Joel Linden; Mark D Okusa
Renal protection from ischemia mediated by A2A adenosine receptors on bone marrow-derived cells.
The Journal of clinical investigation 2003;112(6):883-91.
2003: Jiang-Fan Chen; Rosario Moratalla; Liqun Yu; Ana B Martín; Kui Xu; Elena Bastia; Elizabeth Hackett; Israel Alberti; Michael A Schwarzschild
Inactivation of adenosine A2A receptors selectively attenuates amphetamine-induced behavioral sensitization.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(6):1086-95.
2003: Jacobus P Petzer; Salome Steyn; Kay Castagnoli; Jiang-Fan Chen; Michael A Schwarzschild; Cornelis J Van Der Schyf; Neal Castagnoli
Inhibition of monoamine oxidase B by selective adenosine A2A receptor antagonists.
Bioorganic & medicinal chemistry 2003;11(7):1299-310.
2003: M Carmen Montesinos; Avani Desai; David L Delano; Jiang-Fan Chen; J Stephen Fink; Marlene A Jacobson; Bruce N Cronstein
Adenosine A2A or A3 receptors are required for inhibition of inflammation by methotrexate and its analog MX-68.
Arthritis and rheumatism 2003;48(1):240-7.
2002: Jiang-Fan Chen; Salome Steyn; Roland Staal; Jacobus P Petzer; Kui Xu; Cornelis J Van Der Schyf; Kay Castagnoli; Patricia K Sonsalla; Neal Castagnoli; Michael A Schwarzschild
8-(3-Chlorostyryl)caffeine may attenuate MPTP neurotoxicity through dual actions of monoamine oxidase inhibition and A2A receptor antagonism.
The Journal of biological chemistry 2002;277(39):36040-4.
2002: S Joseph Leibovich; Jiang-Fan Chen; Grace Pinhal-Enfield; Paula C Belem; Genie Elson; Anthony Rosania; Madhuri Ramanathan; Carmen Montesinos; Marlene Jacobson; Michael A Schwarzschild; J Stephen Fink; Bruce N Cronstein
Synergistic up-regulation of vascular endothelial growth factor expression in murine macrophages by adenosine A(2A) receptor agonists and endotoxin.
The American journal of pathology 2002;160(6):2231-44.
2002: M Carmen Montesinos; Avani Desai; Jiang-Fan Chen; Herman Yee; Michael A Schwarzschild; J Stephen Fink; Bruce N Cronstein
Adenosine promotes wound healing and mediates angiogenesis in response to tissue injury via occupancy of A(2A) receptors.
The American journal of pathology 2002;160(6):2009-18.
2002: Michael A Schwarzschild; Jiang-Fan Chen; Alberto Ascherio
Caffeinated clues and the promise of adenosine A(2A) antagonists in PD.
Neurology 2002;58(8):1154-60.
2002: Kui Xu; Yue-Hang Xu; Jiang-Fan Chen; Michael A Schwarzschild
Caffeine's neuroprotection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity shows no tolerance to chronic caffeine administration in mice.
Neuroscience letters 2002;322(1):13-6.
2002: Silva Fredduzzi; Rosario Moratalla; Angela Monopoli; Beatriz Cuellar; Kui Xu; Ennio Ongini; Francesco Impagnatiello; Michael A Schwarzschild; Jiang-Fan Chen
Persistent behavioral sensitization to chronic L-DOPA requires A2A adenosine receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(3):1054-62.
2001: Jiang-Fan Chen; Kui Xu; Jacobus P Petzer; Roland Staal; Yue-Hang Xu; MA Beilstein; Patricia K Sonsalla; Kay Castagnoli; Neal Castagnoli; Michael A Schwarzschild
Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinson's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(10):RC143.
2001: J M Armstrong; Jiang-Fan Chen; Michael A Schwarzschild; Sergey Apasov; Patrick T Smith; Charles C Caldwell; P Chen; H Figler; G Sullivan; S Fink; J Linden; Michail V Sitkovsky
Gene dose effect reveals no Gs-coupled A2A adenosine receptor reserve in murine T-lymphocytes: studies of cells from A2A-receptor-gene-deficient mice.
The Biochemical journal 2001;354(Pt 1):123-30.
2001: Jiang-Fan Chen; Rosario Moratalla; Francesco Impagnatiello; David K Grandy; Beatriz Cuellar; M Rubinstein; MA Beilstein; E Hackett; J Stephen Fink; Malcolm J Low; Ennio Ongini; Michael A Schwarzschild
The role of the D(2) dopamine receptor (D(2)R) in A(2A) adenosine receptor (A(2A)R)-mediated behavioral and cellular responses as revealed by A(2A) and D(2) receptor knockout mice.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1970-5.
2000: Sergey Apasov; Jiang-Fan Chen; Patrick T Smith; Michael A Schwarzschild; J Stephen Fink; Michail V Sitkovsky
Study of A(2A) adenosine receptor gene deficient mice reveals that adenosine analogue CGS 21680 possesses no A(2A) receptor-unrelated lymphotoxicity.
British journal of pharmacology 2000;131(1):43-50.
2000: Sergey Apasov; Jiang-Fan Chen; P Smith; Michail V Sitkovsky
A(2A) receptor dependent and A(2A) receptor independent effects of extracellular adenosine on murine thymocytes in conditions of adenosine deaminase deficiency.
Blood 2000;95(12):3859-67.
2000: M Nakai; Zheng-Hong Qin; Jiang-Fan Chen; Yumei Wang; Thomas N Chase
Kainic acid-induced apoptosis in rat striatum is associated with nuclear factor-kappaB activation.
Journal of neurochemistry 2000;74(2):647-58.
2000: Jiang-Fan Chen; MA Beilstein; Yue-Hang Xu; T J Turner; Rosario Moratalla; David G Standaert; V J Aloyo; J Stephen Fink; Michael A Schwarzschild
Selective attenuation of psychostimulant-induced behavioral responses in mice lacking A(2A) adenosine receptors.
Neuroscience 2000;97(1):195-204.
1999: Jiang-Fan Chen; Z Huang; J Ma; J Zhu; Rosario Moratalla; David G Standaert; Michael A Moskowitz; J Stephen Fink; Michael A Schwarzschild
A(2A) adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(21):9192-200.