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Ken Chen

Research Profile

Living Beings

Mouse

Chemicals & Drugs

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Disorders

Cell Transformation, Neoplastic

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Physiology

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Publications

TOP 3
Kieran Seay; Cong Zhang; Jian Hua Zheng; Ken Chen; Kathryn Deneroff; Monica Dutta; John C Kappes; Dan R Littman; Christina Ochsenbauer; Xiaohua Qi; Harris Goldstein
Mice Transgenic for CD4-Specific Human CD4, CCR5 and Cyclin T1 Expression: A New Model for Investigating HIV-1 Transmission and Treatment Efficacy.
Aviva Joseph; Jian Hua Zheng; Ken Chen; Monica Dutta; Cindy Chen; Gabriela Stiegler; Renate Kunert; Antonia Follenzi; Harris Goldstein
Inhibition of in vivo HIV infection in humanized mice by gene therapy of human hematopoietic stem cells with a lentiviral vector encoding a broadly neutralizing anti-HIV antibody.
Aviva Joseph; Jian Hua Zheng; Antonia Follenzi; Teresa P DiLorenzo; Kaori Sango; Jaime Hyman; Ken Chen; Alicja Piechocka-Trocha; Christian Brander; Erik Hooijberg; Dario A Vignali; Bruce D Walker; Harris Goldstein
Lentiviral vectors encoding human immunodeficiency virus type 1 (HIV-1)-specific T-cell receptor genes efficiently convert peripheral blood CD8 T lymphocytes into cytotoxic T lymphocytes with potent in vitro and in vivo HIV-1-specific inhibitory activity.

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All Publications

2013: Kieran Seay; Cong Zhang; Jian Hua Zheng; Ken Chen; Kathryn Deneroff; Monica Dutta; John C Kappes; Dan R Littman; Christina Ochsenbauer; Xiaohua Qi; Harris Goldstein
Mice Transgenic for CD4-Specific Human CD4, CCR5 and Cyclin T1 Expression: A New Model for Investigating HIV-1 Transmission and Treatment Efficacy.
PloS one 2013;8(5):e63537.
2010: Aviva Joseph; Jian Hua Zheng; Ken Chen; Monica Dutta; Cindy Chen; Gabriela Stiegler; Renate Kunert; Antonia Follenzi; Harris Goldstein
Inhibition of in vivo HIV infection in humanized mice by gene therapy of human hematopoietic stem cells with a lentiviral vector encoding a broadly neutralizing anti-HIV antibody.
Journal of virology 2010;84(13):6645-53.
2008: Aviva Joseph; Jian Hua Zheng; Antonia Follenzi; Teresa P DiLorenzo; Kaori Sango; Jaime Hyman; Ken Chen; Alicja Piechocka-Trocha; Christian Brander; Erik Hooijberg; Dario A Vignali; Bruce D Walker; Harris Goldstein
Lentiviral vectors encoding human immunodeficiency virus type 1 (HIV-1)-specific T-cell receptor genes efficiently convert peripheral blood CD8 T lymphocytes into cytotoxic T lymphocytes with potent in vitro and in vivo HIV-1-specific inhibitory activity.
Journal of virology 2008;82(6):3078-89.
2006: Jia Li; Ken Chen; Liyin Zhu; Jeffrey W Pollard
Conditional deletion of the colony stimulating factor-1 receptor (c-fms proto-oncogene) in mice.
Genesis (New York, N.Y. : 2000) 2006;44(7):328-35.
2003: Janice L Hallows; Ken Chen; Ronald A DePinho; Inez Vincent
Decreased cyclin-dependent kinase 5 (cdk5) activity is accompanied by redistribution of cdk5 and cytoskeletal proteins and increased cytoskeletal protein phosphorylation in p35 null mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(33):10633-44.
2002: Leila Alland; Gregory David; Hong Shen-Li; Jason Potes; Rebecca Muhle; Hye-Chun Lee; Harry Hou; Ken Chen; Ronald A DePinho
Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex.
Molecular and cellular biology 2002;22(8):2743-50.
2000: Rónán C O'Hagan; N Schreiber-Agus; Ken Chen; Gregory David; J A Engelman; R Schwab; Leila Alland; C Thomson; Donald Ronning; J C Sacchettini; P Meltzer; Ronald A DePinho
Gene-target recognition among members of the myc superfamily and implications for oncogenesis.
Nature genetics 2000;24(2):113-9.
1998: Nicole Schreiber-Agus; Y Meng; T Hoang; Harry Hou; Ken Chen; Roger A. Greenberg; C Cordon-Cardo; H W Lee; Ronald A DePinho
Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth.
Nature 1998;393(6684):483-7.
1998: J Pomerantz; N Schreiber-Agus; NANETTE LIEGEOIS; A Silverman; Leila Alland; Lynda Chin; Jason Potes; Ken Chen; Irene Orlow; H W Lee; Carlos Cordon-Cardo; Ronald A DePinho
The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53.
Cell 1998;92(6):713-23.
1997: N Schreiber-Agus; David Stein; Ken Chen; J S Goltz; L Stevens; Ronald A DePinho
Drosophila Myc is oncogenic in mammalian cells and plays a role in the diminutive phenotype.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(4):1235-40.
1997: N Schreiber-Agus; Leila Alland; Rebecca Muhle; J Goltz; Ken Chen; L Stevens; David Stein; Ronald A DePinho
A biochemical and biological analysis of Myc superfamily interactions.
Current topics in microbiology and immunology 1997;224():159-68.
1996: G Rao; Leila Alland; P Guida; N Schreiber-Agus; Ken Chen; Lynda Chin; J M Rochelle; Michael F Seldin; Arthur I Skoultchi; Ronald A DePinho
Mouse Sin3A interacts with and can functionally substitute for the amino-terminal repression of the Myc antagonist Mxi1.
Oncogene 1996;12(5):1165-72.
1995: Lynda Chin; N Schreiber-Agus; I Pellicer; Ken Chen; H W Lee; M Dudast; Carlos Cordon-Cardo; Ronald A DePinho
Contrasting roles for Myc and Mad proteins in cellular growth and differentiation.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(18):8488-92.
1995: N Schreiber-Agus; Lynda Chin; Ken Chen; R Torres; G Rao; P Guida; Arthur I Skoultchi; Ronald A DePinho
An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3.
Cell 1995;80(5):777-86.
1994: N Schreiber-Agus; Lynda Chin; Ken Chen; R Torres; C T Thomson; J C Sacchettini; Ronald A DePinho
Evolutionary relationships and functional conservation among vertebrate Max-associated proteins: the zebra fish homolog of Mxi1.
Oncogene 1994;9(11):3167-77.