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Lieping Chen

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Kirk D C Jensen; Lindsay Julien; Diana Lu; Lieping Chen; Musa A Hassan; Kenneth Hu; Christopher A Hunter; Ryan J Whitmarsh; jeroen saeij
Toxoplasma gondii Rhoptry 16 Kinase Promotes Host Resistance to Oral Infection and Intestinal Inflammation Only in the Context of the Dense Granule Protein GRA15.
Lieping Chen; Dallas B Flies
Molecular mechanisms of T cell co-stimulation and co-inhibition.
Sofia Lyford-Pike; Belinda Akpeng; Justin A Bishop; Tullia C Bruno; Lieping Chen; Charles G Drake; Drew M Pardoll; Shiwen Peng; Jeremy D Richmon; Janis M Taube; Suzanne Topalian; Hao Wang; William H Westra; Geoffrey D Young; Sara I Pai
Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma.

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2013: Kirk D C Jensen; Lindsay Julien; Diana Lu; Lieping Chen; Musa A Hassan; Kenneth Hu; Christopher A Hunter; Ryan J Whitmarsh; jeroen saeij
Toxoplasma gondii Rhoptry 16 Kinase Promotes Host Resistance to Oral Infection and Intestinal Inflammation Only in the Context of the Dense Granule Protein GRA15.
Infection and immunity 2013;81(6):2156-67.
2013: Lieping Chen; Dallas B Flies
Molecular mechanisms of T cell co-stimulation and co-inhibition.
Nature reviews. Immunology 2013;13(4):227-42.
2013: Sofia Lyford-Pike; Belinda Akpeng; Justin A Bishop; Tullia C Bruno; Lieping Chen; Charles G Drake; Drew M Pardoll; Shiwen Peng; Jeremy D Richmon; Janis M Taube; Suzanne Topalian; Hao Wang; William H Westra; Geoffrey D Young; Sara I Pai
Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma.
Cancer research 2013;73(6):1733-41.
2013: Mario Sznol; Lieping Chen
Antagonist antibodies to PD-1 and B7-H1 (PD-L1) in the treatment of advanced human cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(5):1021-34.
2013: Sheng Yao; Lieping Chen
Adaptive resistance: a tumor strategy to evade immune attack.
European journal of immunology 2013;43(3):576-9.
2013: Sheng Yao; Yuwen Zhu; Lieping Chen
Advances in targeting cell surface signalling molecules for immune modulation.
Nature reviews. Drug discovery 2013;12(2):130-46.
2013: H Tamura; Sakae Tanosaki; T Yamashita; Lieping Chen; Kazuo Dan; H Dong; H Hyodo; M Ishibashi; A Kondo; N Okuyama; Eiji SHINYA; H Takahashi; Koji Tamada; K Ogata
Marrow stromal cells induce B7-H1 expression on myeloma cells, generating aggressive characteristics in multiple myeloma.
Leukemia 2013;27(2):464-72.
2013: Xiaojie Wang; Noushin Akhoundsadegh; Ziliang Ao; Lieping Chen; Jianqiang Hao; I-Fang Lee; Daniel L Metzger; Alice L-F Mui; Dawei Ou; C Bruce Verchere; Garth L Warnock
Endogenous expression of B7-H4 improves long-term murine islet allograft survival.
Transplantation 2013;95(1):94-9.
2013: Evan J Lipson; Drew M Pardoll; Alice Pons; WILLIAM SHARFMAN; Janis M Taube; Robert A Anders; Julie R Brahmer; Lieping Chen; Charles G Drake; Ira Wollner; Haiying Xu; Sheng Yao; Suzanne Topalian
Durable cancer regression off-treatment and effective reinduction therapy with an anti-PD-1 antibody.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(2):462-8.
2013: S Yoshikawa; Lieping Chen; T Fujimoto; N Handa; S Kawa; T Kobayashi; Mutsuko Kukimoto-Niino; Z-J Liu; L Parker; S Sano; M Sato; K Semba; Mikako Shirouzu; T Tanaka; Takaho Terada; Y Terazawa; Motoaki Wakiyama; B-C Wang; Tadashi Yamamoto; Shigeyuki Yokoyama
Structural basis for the altered drug sensitivities of non-small cell lung cancer-associated mutants of human epidermal growth factor receptor.
Oncogene 2013;32(1):27-38.
2013: Elaine Bigelow; Lieping Chen; Elizabeth M Jaffee; Janis M Taube; Annie Wu; Haiying Xu; Allison Yager; Robert A Anders; Katherine M Bever; Lei Zheng
Immunohistochemical staining of B7-H1 (PD-L1) on paraffin-embedded slides of pancreatic adenocarcinoma tissue.
Journal of visualized experiments : JoVE 2013;(71):.
2012: Eric F Tewalt; Kenneth S Tung; Anthony T Vella; Adam J Adler; Timothy P Bender; Lieping Chen; Jarish N Cohen; Mark R Conaway; Shawn P Fahl; Cynthia J Guidi; Hui Qiao; Sherin J Rouhani; Victor H Engelhard
Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells.
Blood 2012;120(24):4772-82.
2012: Suzanne Topalian; JON WIGGINTON; Haiying Xu; Janis M Taube; Shruti Agrawal; Robert A Anders; Scott J Antonia; Michael B Atkins; Julie R Brahmer; Richard D Carvajal; Lieping Chen; Charles G Drake; Scott N Gettinger; Ashok Gupta; F Stephen Hodi; Leora Horn; Maria Jure-Kunkel; Georgia D Kollia; Alan J Korman; Philip D Leming; David F McDermott; Daniel McDonald; Tracee L McMiller; Drew M Pardoll; John D Powderly; WILLIAM SHARFMAN; David C Smith; Jeffrey A Sosman; David R Spigel; Mario Sznol
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.
The New England journal of medicine 2012;366(26):2443-54.
2012: Magali Terme; Evelyn Ullrich; Sophie Viaud; Hideo Yagita; Laetitia Aymeric; Nathalie Chaput; Lieping Chen; Jerome Coudert; Mariapia Degli-Esposti; Mélanie Desbois; François Ghiringhelli; Gilles Kaplanski; Masashi Kato; Guido Kroemer; Salaheddine Mécheri; Kathrin Meinhardt; Armelle Prévost-Blondel; Bernard Ryffel; Joachim L Schultze; Eric Tartour; Laurence Zitvogel
Cancer-induced immunosuppression: IL-18-elicited immunoablative NK cells.
Cancer research 2012;72(11):2757-67.
2012: Ryan A Wilcox; Weiping Zou; Stephen M Ansell; Megan S Lim; Lieping Chen
The B7 homologues and their receptors in hematologic malignancies.
European journal of haematology 2012;88(6):465-75.
2012: Janis M Taube; Suzanne Topalian; Haiying Xu; Geoffrey D Young; Shuming Chen; Alison P Klein; Tracee L McMiller; Drew M Pardoll; Rajni Sharma; Robert A Anders; Lieping Chen
Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape.
Science translational medicine 2012;4(127):127ra37.
2012: Holbrook E Kohrt; Robert W Carlson; Lieping Chen; Michael F Clarke; A Dimitrios Colevas; Debra Czerwinski; Matthew J Goldstein; Roch Houot; Joseph A Mollick; Ferenc Scheeren; Frank E Stockdale; Kipp Weiskopf; Wen-Kai Weng; Ronald Levy
Stimulation of natural killer cells with a CD137-specific antibody enhances trastuzumab efficacy in xenotransplant models of breast cancer.
The Journal of clinical investigation 2012;122(3):1066-75.
2012: Jang-June Park; Yukimi Sakoda; Scott E Strome; Sudarshan Anand; Lieping Chen; Atsuo Kuramasu; Yumiko Matsumura; Yuming Zhao; Koji Tamada
Expression of anti-HVEM single-chain antibody on tumor cells induces tumor-specific immunity with long-term memory.
Cancer immunology, immunotherapy : CII 2012;61(2):203-14.
2012: Xiaofan Li; Paul Martin; Wendong Huang; Wei He; James Young; Chantal Du; Yuanzhong Chen; Miao Wang; Ruishu Deng; Stephen Forman; Lieping Chen; Zhipeng Meng; Can Liu; Defu Zeng
Loss of B7-H1 expression by recipient parenchymal cells leads to expansion of infiltrating donor CD8+ T cells and persistence of graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(2):724-34.
2012: X H Diao; Y Pang; Lieping Chen; Y Chen; J Zhu
Automated volume scanner system ultrasonography for evaluation of varicose veins of the lower extremities.
The Journal of international medical research 2012;40(6):2160-6.
2012: Horng-Tay Tzeng; Lieping Chen; Pei-Jer Chen; Hsiu-Jung Liao; Yi-Jiun Lin; Hwei-Fang Tsai; Ping-Ning Hsu
PD-1 blockage reverses immune dysfunction and hepatitis B viral persistence in a mouse animal model.
PloS one 2012;7(6):e39179.
2012: Xiaojie Wang; Ziliang Ao; Daniel L Metzger; Dawei Ou; Jianqiang Hao; Alice Mui; Lieping Chen; C Bruce Verchere; Garth L Warnock
B7-H4 Treatment of T Cells Inhibits ERK, JNK, p38, and AKT Activation.
PloS one 2012;7(1):e28232.
2012: Y Luan; J Wang; Z Zhang; F-S Wang; L Cheng; S-Y Zhang; L Luo; Lieping Chen; D-M Zhu; J Ju; Shengdian Wang
Potential role of soluble B7-H3 in liver immunopathogenesis during chronic HBV infection.
Journal of viral hepatitis 2012;19(1):23-31.
2012: Xiaojie Wang; Ziliang Ao; Lieping Chen; Jianqiang Hao; Daniel L Metzger; Alice L-F Mui; Dawei Ou; C Bruce Verchere; Garth L Warnock
B7-H4 induces donor-specific tolerance in mouse islet allografts.
Cell transplantation 2012;21(1):99-111.
2011: Dallas B Flies; Britt J Sandler; Mario Sznol; Lieping Chen
Blockade of the B7-H1/PD-1 pathway for cancer immunotherapy.
The Yale journal of biology and medicine 2011;84(4):409-21.
2011: Yukimi Sakoda; Scott E Strome; Nico van Rooijen; Yuming Zhao; Sudarshan Anand; Ling Chen; Lieping Chen; Wayne W Hancock; Atsuo Kuramasu; Yingjia Liu; Jang-June Park; Koji Tamada
Herpesvirus entry mediator regulates hypoxia-inducible factor-1α and erythropoiesis in mice.
The Journal of clinical investigation 2011;121(12):4810-9.
2011: Xiaojie Wang; Noushin Akhoundsadegh; Ziliang Ao; Lieping Chen; Jianqiang Hao; Solomon Langermann; Linda Liu; Daniel L Metzger; Alice Mui; Dawei Ou; C Bruce Verchere; Garth L Warnock
Early treatment of NOD mice with B7-H4 reduces the incidence of autoimmune diabetes.
Diabetes 2011;60(12):3246-55.
2011: L Yang; Yate-Ching Yuan; K Zhang; Lieping Chen; X Deng; C C H Kim; S Lau; G Somlo; Y Wang; J Wu; X Wu; Y Yen
FZD7 has a critical role in cell proliferation in triple negative breast cancer.
Oncogene 2011;30(43):4437-46.
2011: Dallas B Flies; Shengdian Wang; Haiying Xu; Lieping Chen
Cutting edge: A monoclonal antibody specific for the programmed death-1 homolog prevents graft-versus-host disease in mouse models.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(4):1537-41.
2011: Junke Zheng; Shichuan Zhang; Benjamin P C Chen; Lieping Chen; HoangDinh Huynh; Robert Silvany; Masato Umikawa; Cheng Cheng Zhang
Ex vivo expanded hematopoietic stem cells overcome the MHC barrier in allogeneic transplantation.
Cell stem cell 2011;9(2):119-30.
2011: Xue Han; Yang Liu; Liqun Luo; Peiying Ye; Linghua Zheng; Lieping Chen; Shengdian Wang
The development and functions of CD4(+) T cells expressing a transgenic TCR specific for an MHC-I-restricted tumor antigenic epitope.
Cellular & molecular immunology 2011;8(4):333-40.
2011: SHENG YAO; Yuwen Zhu; Gefeng Zhu; Mathew Augustine; Linghua Zheng; Diana J Goode; Megan Broadwater; William Ruff; Sarah Flies; Haiying Xu; Dallas Flies; Liqun Luo; Shengdian Wang; Lieping Chen
B7-h2 is a costimulatory ligand for CD28 in human.
Immunity 2011;34(5):729-40.
2011: Emily Hams; Mark J McCarron; Sylvie Amu; Hideo Yagita; Miyuki Azuma; Lieping Chen; Padraic G Fallon
Blockade of B7-H1 (programmed death ligand 1) enhances humoral immunity by positively regulating the generation of T follicular helper cells.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(10):5648-55.
2011: Yasuhiro Mouri; Masashi Yano; Miho Shinzawa; Yusuke Shimo; Fumiko Hirota; Yumiko Nishikawa; Takuro Nii; Hiroshi Kiyonari; Takaya Abe; Hisanori Uehara; Keisuke Izumi; Koji Tamada; Lieping Chen; Josef M Penninger; Jun-ichiro Inoue; Taishin Akiyama; Mitsuru Matsumoto
Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(9):5047-57.
2011: Yuwen Zhu; SHENG YAO; Lieping Chen
Cell surface signaling molecules in the control of immune responses: a tide model.
Immunity 2011;34(4):466-78.
2011: Tangsheng Yi; Xiaofan Li; SHENG YAO; Lin Wang; Yuhong Chen; Dongchang Zhao; Heather F Johnston; James S Young; Hongjun Liu; Ivan Todorov; Stephen J Forman; Lieping Chen; Defu Zeng
Host APCs augment in vivo expansion of donor natural regulatory T cells via B7H1/B7.1 in allogeneic recipients.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(5):2739-49.
2011: Anna Scuto; P Krejci; L Popplewell; J Wu; Y Wang; M Kujawski; Claudia M Kowolik; H Xin; Lieping Chen; Y Wang; L Kretzner; Hua Yu; W R Wilcox; Yun Yen; Stephen Forman; Richard Jove
The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival.
Leukemia 2011;25(3):538-50.
2011: Holbrook E Kohrt; Roch Houot; Matthew J Goldstein; Kipp Weiskopf; Ash A Alizadeh; Josh Brody; Antonia Müller; Russell Pachynski; Debra K Czerwinski; Steven Coutre; Mark P Chao; Lieping Chen; Thomas F Tedder; Ronald Levy
CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodies.
Blood 2011;117(8):2423-32.
2011: Xiaojie Wang; Ziliang Ao; Lieping Chen; Jianqiang Hao; Mark Meloche; Daniel L Metzger; Alice L-F Mui; Dawei Ou; C Bruce Verchere; Garth L Warnock
B7-H4 Pathway in Islet Transplantation and β-Cell Replacement Therapies.
Journal of transplantation 2011;2011():418902.
2011: Lieping Chen; S H Gu; Yu-Dong Gu; H W Huang; L Xu; Jian-Guang Xu
The study of myogenin expression in denervated human skeletal muscles.
The Journal of international medical research 2011;39(2):378-87.
2011: Shengdian Wang; Lieping Chen
Immunobiology of cancer therapies targeting CD137 and B7-H1/PD-1 cosignal pathways.
Current topics in microbiology and immunology 2011;344():245-67.
2010: Jun Wang; Wenxia Zhao; Liang Cheng; Mingzhou Guo; Dongling Li; Xiaozhu Li; Yi Tan; Suping Ma; Suyun Li; Yunsheng Yang; Lieping Chen; Shengdian Wang
CD137-mediated pathogenesis from chronic hepatitis to hepatocellular carcinoma in hepatitis B virus-transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(12):7654-62.
2010: Loc T Nguyen; Bogoljub Ciric; Virginia P Van Keulen; Moses Rodriguez; Larry R Pease; Koji Tamada; Dallas B Flies; Lieping Chen
Retraction: Immunotherapeutic potential of B7-DC (PD-L2) cross-linking antibody in conferring antitumor immunity.
Cancer research 2010;70(22):9528.
2010: Keith M Hamel; Yanxia Cao; Yumei Wang; Rachel Rodeghero; Tamas Kobezda; Lieping Chen; Alison Finnegan
B7-H1 expression on non-B and non-T cells promotes distinct effects on T- and B-cell responses in autoimmune arthritis.
European journal of immunology 2010;40(11):3117-27.
2010: Tomohiro Fukaya; Hideaki Takagi; Yumiko Sato; Katsuaki Sato; Kawori Eizumi; Honami Taya; Tae Kwang Shin; Lieping Chen; Chen Dong; Miyuki Azuma; Hideo Yagita; Bernard Malissen; Katsuaki Sato
Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance.
Blood 2010;116(13):2266-76.
2010: Pei-Yi Lin; Lishi Sun; Suzanne R Thibodeaux; Sara M Ludwig; Ratna K Vadlamudi; vincent hurez; Rumana Bahar; Mark J Kious; Carolina B Livi; Shawna R Wall; Lieping Chen; Bin Zhang; Tae Kwang Shin; Tyler J Curiel
B7-H1-dependent sex-related differences in tumor immunity and immunotherapy responses.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(5):2747-53.
2010: Jang-June Park; Ryusuke Omiya; Yumiko Matsumura; Yukimi Sakoda; Atsuo Kuramasu; Mathew M Augustine; SHENG YAO; Fumihiko Tsushima; Hidehiko Narazaki; Sudarshan Anand; Yingjia Liu; Scott E Strome; Lieping Chen; Koji Tamada
B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance.
Blood 2010;116(8):1291-8.
2010: Asaka Kondo; Taishi Yamashita; Hideto Tamura; Wanhong Zhao; Takashi Tsuji; Masumi Shimizu; Eiji SHINYA; Hidemi Takahashi; Koji Tamada; Lieping Chen; Kazuo Dan; Kiyoyuki Ogata
Interferon-gamma and tumor necrosis factor-alpha induce an immunoinhibitory molecule, B7-H1, via nuclear factor-kappaB activation in blasts in myelodysplastic syndromes.
Blood 2010;116(7):1124-31.
2010: Tarvo Rajasalu; Helen Brosi; Cornelia Schuster; Andreas Spyrantis; Bernhard Otto Boehm; Lieping Chen; Jörg Reimann; Reinhold Schirmbeck
Deficiency in B7-H1 (PD-L1)/PD-1 coinhibition triggers pancreatic beta-cell destruction by insulin-specific, murine CD8 T-cells.
Diabetes 2010;59(8):1966-73.
2010: Juan Dubrot; Francisca Milheiro; Carlos Alfaro; Asis Palazón; Ivan Martinez-Forero; Jose L Perez-Gracia; Aizea Morales-Kastresana; José L Romero-Trevejo; María C Ochoa; Sandra Hervás-Stubbs; Jesús Prieto; Maria Jure-Kunkel; Lieping Chen; Ignacio Melero
Treatment with anti-CD137 mAbs causes intense accumulations of liver T cells without selective antitumor immunotherapeutic effects in this organ.
Cancer immunology, immunotherapy : CII 2010;59(8):1223-33.
2010: T Wang; E B Ahmed; Lieping Chen; Jianming Xu; J Tao; Chyung-Ru Wang; Maria-Luisa Alegre; Anita S Chong
Infection with the intracellular bacterium, Listeria monocytogenes, overrides established tolerance in a mouse cardiac allograft model.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2010;10(7):1524-33.
2010: Julie R Brahmer; Charles G Drake; Ira Wollner; John D Powderly; Joel Picus; WILLIAM SHARFMAN; Elizabeth Stankevich; Alice Pons; Theresa M Salay; Tracee L McMiller; MARTA GILSON; Changyu Wang; Mark Selby; Janis M Taube; Robert A Anders; Lieping Chen; Alan J Korman; Drew M Pardoll; Israel Lowy; Suzanne Topalian
Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(19):3167-75.
2010: Loc T Nguyen; Bogoljub Ciric; Daren R Ure; Bin Zhou; Koji Tamada; Su-Yi Tseng; Tae Kwang Shin; Lieping Chen; Haidong Dong; Robert A Kyle; Moses Rodriguez; Larry R Pease
Retraction: Naturally occurring human IgM antibody that binds B7-DC and potentiates T cell stimulation by dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(11):6552.
2010: Kim L Good-Jacobson; Courtney G Szumilas; Lieping Chen; Arlene H Sharpe; Mary M Tomayko; Mark J Shlomchik
PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells.
Nature immunology 2010;11(6):535-42.
2010: Hidehiko Narazaki; Yuwen Zhu; Liqun Luo; Gefeng Zhu; Lieping Chen
CD137 agonist antibody prevents cancer recurrence: contribution of CD137 on both hematopoietic and nonhematopoietic cells.
Blood 2010;115(10):1941-8.
2010: Kenji Ishiwata; Naohiro Watanabe; Miao Guo; Kei Tomihara; Michael J Brumlik; Hideo Yagita; Drew M Pardoll; Lieping Chen; Tae Kwang Shin
Costimulator B7-DC attenuates strong Th2 responses induced by Nippostrongylus brasiliensis.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(4):2086-94.
2010: Shengdian Wang; Lieping Chen
Structural immunology of costimualtory and coinhibitory molecules.
Science China. Life sciences 2010;53(2):183-9.
2009: Ryusuke Omiya; Fumihiko Tsushima; Hidehiko Narazaki; Yukimi Sakoda; Atsuo Kuramasu; Youn Kim; Haiying Xu; Hideto Tamura; Gefeng Zhu; Lieping Chen; Koji Tamada
Leucocyte-associated immunoglobulin-like receptor-1 is an inhibitory regulator of contact hypersensitivity.
Immunology 2009;128(4):543-55.
2009: Antonino Castellaneta; Tina L Sumpter; Lieping Chen; Daisuke Tokita; Angus W Thomson
NOD2 ligation subverts IFN-alpha production by liver plasmacytoid dendritic cells and inhibits their T cell allostimulatory activity via B7-H1 up-regulation.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(11):6922-32.
2009: Ke Wu; Ilona Kryczek; Lieping Chen; Weiping Zou; Theodore H Welling III
Kupffer cell suppression of CD8+ T cells in human hepatocellular carcinoma is mediated by B7-H1/programmed death-1 interactions.
Cancer research 2009;69(20):8067-75.
2009: Rezaul Karim; Ekaterina S. Jordanova; Sytse J Piersma; Gemma G Kenter; Lieping Chen; Judith M Boer; Cornelis J M Melief; Sjoerd H van der burg
Tumor-expressed B7-H1 and B7-DC in relation to PD-1+ T-cell infiltration and survival of patients with cervical carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(20):6341-7.
2009: Roch Houot; Matthew J Goldstein; Holbrook E Kohrt; June H Myklebust; Ash A Alizadeh; Jack T Lin; Jonathan M Irish; James A Torchia; Arne Kolstad; Lieping Chen; Ronald Levy
Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by Treg depletion.
Blood 2009;114(16):3431-8.
2009: Takeshi Azuma; Gefeng Zhu; Haiying Xu; A Cecilia Rietz; Charles G Drake; Eric L Matteson; Lieping Chen
Potential role of decoy B7-H4 in the pathogenesis of rheumatoid arthritis: a mouse model informed by clinical data.
PLoS medicine 2009;6(10):e1000166.
2009: Tangsheng Yi; Ying Chen; Lin Wang; Gong Du; Daniel Huang; Dongchang Zhao; Heather Johnston; James Young; Ivan Todorov; Dale T Umetsu; Lieping Chen; Yoichiro Iwakura; Fouad Kandeel; Stephen Forman; Defu Zeng
Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease.
Blood 2009;114(14):3101-12.
2009: Yonglian Sun; Nicholas K Brown; Matthew J Ruddy; Mendy L Miller; Youjin Lee; Yang Wang; Kenneth M Murphy; Klaus Pfeffer; Lieping Chen; Jonathan Kaye; Yang-Xin Fu
B and T lymphocyte attenuator tempers early infection immunity.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(3):1946-51.
2009: SHENG YAO; Shengdian Wang; Yuwen Zhu; Liqun Luo; Gefeng Zhu; Sarah Flies; Haiying Xu; William Ruff; Megan Broadwater; In-Hak Choi; Koji Tamada; Lieping Chen
PD-1 on dendritic cells impedes innate immunity against bacterial infection.
Blood 2009;113(23):5811-8.
2009: Kyung H Yi; Lieping Chen
Fine tuning the immune response through B7-H3 and B7-H4.
Immunological reviews 2009;229(1):145-51.
2009: Timothy W Phares; Chandran Ramakrishna; Gabriel I Parra; Alan Epstein; Lieping Chen; Roscoe Atkinson; Stephen A Stohlman; Cornelia C Bergmann
Target-dependent B7-H1 regulation contributes to clearance of central nervous system infection and dampens morbidity.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(9):5430-8.
2009: Ignacio Melero; Ivan Martinez-Forero; Juan Dubrot; Natalia Suarez; Asis Palazón; Lieping Chen
Palettes of vaccines and immunostimulatory monoclonal antibodies for combination.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(5):1507-9.
2009: Yuwen Zhu; Lieping Chen
Turning the tide of lymphocyte costimulation.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(5):2557-8.
2009: Xiaojie Wang; Jianqiang Hao; Daniel L Metzger; Alice L-F Mui; Ziliang Ao; C Bruce Verchere; Lieping Chen; Dawei Ou; Garth L Warnock
Local expression of B7-H4 by recombinant adenovirus transduction in mouse islets prolongs allograft survival.
Transplantation 2009;87(4):482-90.
2009: Oezcan Talay; Ching-Hung Shen; Lieping Chen; Jianzhu Chen
B7-H1 (PD-L1) on T cells is required for T-cell-mediated conditioning of dendritic cell maturation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(8):2741-6.
2009: Gefeng Zhu; Mathew M Augustine; Takeshi Azuma; Liqun Luo; SHENG YAO; Sudarshan Anand; A Cecilia Rietz; Jiaqiang Huang; Haiying Xu; Andrew S Flies; Sarah J Flies; Koji Tamada; Marco COLONna; Jan M A van Deursen; Lieping Chen
B7-H4-deficient mice display augmented neutrophil-mediated innate immunity.
Blood 2009;113(8):1759-67.
2009: Taishi Yamashita; Hideto Tamura; Chikako Satoh; Eiji SHINYA; Hidemi Takahashi; Lieping Chen; Asaka Kondo; Takashi Tsuji; Kazuo Dan; Kiyoyuki Ogata
Functional B7.2 and B7-H2 molecules on myeloma cells are associated with a growth advantage.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(3):770-7.
2009: C A Crane; Amith Panner; J C Murray; S P Wilson; H Xu; Lieping Chen; Jeff Simko; Frederic M Waldman; Russell O Pieper; A T Parsa
PI(3) kinase is associated with a mechanism of immunoresistance in breast and prostate cancer.
Oncogene 2009;28(2):306-12.
2008: Ilona Kryczek; Shuang Wei; Wenrong Gong; Xiaogong Shu; Wojciech Szeliga; Linhua Vatan; Lieping Chen; Guobin Wang; Weiping Zou
Cutting edge: IFN-gamma enables APC to promote memory Th17 and abate Th1 cell development.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(9):5842-6.
2008: Bettina Schreiner; Samantha L Bailey; Tae Kwang Shin; Lieping Chen; Stephen D Miller
PD-1 ligands expressed on myeloid-derived APC in the CNS regulate T-cell responses in EAE.
European journal of immunology 2008;38(10):2706-17.
2008: Christian Wahl; Petra Bochtler; Lieping Chen; Reinhold Schirmbeck; Jörg Reimann
B7-H1 on hepatocytes facilitates priming of specific CD8 T cells but limits the specific recall of primed responses.
Gastroenterology 2008;135(3):980-8.
2008: Wei Lin; Caroline J Voskens; Xiaoyu Zhang; Daniel G Schindler; Aaron Wood; Erin Burch; Yadong Wei; Lieping Chen; Guoliang Tian; Koji Tamada; Lai-Xi Wang; Dan H Schulze; Dean L Mann; Scott E Strome
Fc-dependent expression of CD137 on human NK cells: insights into "agonistic" effects of anti-CD137 monoclonal antibodies.
Blood 2008;112(3):699-707.
2008: Shuang Wei; Andrew B Shreiner; Nobuhiro Takeshita; Lieping Chen; Weiping Zou; Alfred E Chang
Tumor-induced immune suppression of in vivo effector T-cell priming is mediated by the B7-H1/PD-1 axis and transforming growth factor beta.
Cancer research 2008;68(13):5432-8.
2008: Weiping Zou; Lieping Chen
Inhibitory B7-family molecules in the tumour microenvironment.
Nature reviews. Immunology 2008;8(6):467-77.
2008: Marie-Edith Lafon; Françoise Mégret; Sven G Meuth; Ole Simon; Myriam L Velandia Romero; Mireille Lafage; Lieping Chen; Lena Alexopoulou; Richard A Flavell; Christophe Prehaud; Heinz Wiendl
Detrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitis.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(11):7506-15.
2008: Sonja Ortler; Christoph Leder; Michel Mittelbronn; Alla L Zozulya; Percy A Knolle; Lieping Chen; Antje Kroner; Heinz Wiendl
B7-H1 restricts neuroantigen-specific T cell responses and confines inflammatory CNS damage: implications for the lesion pathogenesis of multiple sclerosis.
European journal of immunology 2008;38(6):1734-44.
2008: Takeshi Azuma; SHENG YAO; Gefeng Zhu; Andrew S Flies; Sarah J Flies; Lieping Chen
B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells.
Blood 2008;111(7):3635-43.
2008: Peder S Olofsson; Leif A Söderström; Dick Wågsäter; Yuri Sheikine; Pauline Ocaya; François Lang; Catherine Rabu; Lieping Chen; Mats Rudling; Pål Aukrust; Ulf Hedin; Gabrielle Paulsson-Berne; Allan Sirsjö; Göran K Hansson
CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypercholesterolemic mice.
Circulation 2008;117(10):1292-301.
2008: Hye-Young Jeong; Youn Jae Lee; Su-Kil Seo; Soo-Woong Lee; Sung-Jae Park; Jeong Nyeo Lee; Hae-Sook Sohn; SHENG YAO; Lieping Chen; Inhak Choi
Blocking of monocyte-associated B7-H1 (CD274) enhances HCV-specific T cell immunity in chronic hepatitis C infection.
Journal of leukocyte biology 2008;83(3):755-64.
2008: Gretchen Hermes; James W Ajioka; Krystyna A Kelly; Ernest J Mui; Fiona Roberts; Kristen Kasza; Thomas Mayr; Michael J Kirisits; Robert Wollmann; David J P Ferguson; Craig William Roberts; Jong-Hee Hwang; Toria Trendler; Richard P Kennan; Yasuhiro Suzuki; Catherine Reardon-Alulis; William F Hickey; Lieping Chen; Rima McLeod
Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection.
Journal of neuroinflammation 2008;5():48.
2008: James O McNamara; Despina Kolonias; Fernando Pastor; Robert S Mittler; Lieping Chen; Paloma H Giangrande; Bruce A Sullenger; Eli Gilboa
Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice.
The Journal of clinical investigation 2008;118(1):376-86.
2008: Linda Diehl; Anna Schurich; Regina Grochtmann; Silke Hegenbarth; Lieping Chen; Percy A Knolle
Tolerogenic maturation of liver sinusoidal endothelial cells promotes B7-homolog 1-dependent CD8+ T cell tolerance.
Hepatology (Baltimore, Md.) 2008;47(1):296-305.
2008: Su K Seo; Hye-Young Jeong; Sae-Gwang Park; Soo-Woong Lee; Il-Whan Choi; Lieping Chen; Inhak Choi
Blockade of endogenous B7-H1 suppresses antibacterial protection after primary Listeria monocytogenes infection.
Immunology 2008;123(1):90-9.
2007: Tsvetelina Pentcheva-Hoang; Lieping Chen; Drew M Pardoll; James P Allison
Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(45):17765-70.
2007: Ilona Kryczek; Shuang Wei; Gefeng Zhu; Leann Myers; Peter Mottram; Pui Cheng; Lieping Chen; George Coukos; Weiping Zou
Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma.
Cancer research 2007;67(18):8900-5.
2007: Mansour Mohamadzadeh; Lieping Chen; Alan L Schmaljohn
How Ebola and Marburg viruses battle the immune system.
Nature reviews. Immunology 2007;7(7):556-67.
2007: Monica V Goldberg; Charles H Maris; Edward L Hipkiss; Andrew S Flies; Lijie Zhen; Rubin M Tuder; Joseph Grosso; Timothy J Harris; Derese Getnet; Katharine A Whartenby; Dirk G Brockstedt; Thomas W Dubensky; Lieping Chen; Drew M Pardoll; Charles G Drake
Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells.
Blood 2007;110(1):186-92.
2007: Fumihiko Tsushima; SHENG YAO; Tae Kwang Shin; Andrew S Flies; Sarah Flies; Haiying Xu; Koji Tamada; Drew M Pardoll; Lieping Chen
Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy.
Blood 2007;110(1):180-5.
2007: Yuwen Zhu; Gefeng Zhu; Liqun Luo; Andrew S Flies; Lieping Chen
CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype.
Blood 2007;109(11):4882-9.
2007: Lieping Chen; Zheng Zhang; Weiwei Chen; Zhidong Zhang; Yonggang Li; Ming Shi; Jiyuan Zhang; Lieping Chen; Shengdian Wang; Fu-Sheng Wang
B7-H1 up-regulation on myeloid dendritic cells significantly suppresses T cell immune function in patients with chronic hepatitis B.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(10):6634-41.
2007: Yanhui Xu; Andrew S Flies; Dallas B Flies; Gefeng Zhu; Sudarshan Anand; Sarah J Flies; Haiying Xu; Robert A Anders; Wayne W Hancock; Lieping Chen; Koji Tamada
Selective targeting of the LIGHT-HVEM costimulatory system for the treatment of graft-versus-host disease.
Blood 2007;109(9):4097-104.
2007: Dallas B Flies; Lieping Chen
The new B7s: playing a pivotal role in tumor immunity.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2007;30(3):251-60.
2007: Liguo Niu; Simona Strahotin; Becker Hewes; Benyue Zhang; Yuanyuan Zhang; David Archer; H Trent Spencer; Dirck L Dillehay; Byungsuk Kwon; Lieping Chen; Anthony T Vella; Robert S Mittler
Cytokine-mediated disruption of lymphocyte trafficking, hemopoiesis, and induction of lymphopenia, anemia, and thrombocytopenia in anti-CD137-treated mice.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(7):4194-213.
2007: Ignacio Melero; Sandra Hervas-Stubbs; Martin J Glennie; Drew M Pardoll; Lieping Chen
Immunostimulatory monoclonal antibodies for cancer therapy.
Nature reviews. Cancer 2007;7(2):95-106.
2007: Stefania Piconi; Daria Trabattoni; Marina Saresella; Enrico Iemoli; Monica Schenal; Alessandra Fusi; Manuela Borelli; Lieping Chen; Ambra Mascheri; Mario Clerici
Effects of specific immunotherapy on the B7 family of costimulatory molecules in allergic inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(3):1931-7.
2007: Yanhui Xu; Koji Tamada; Lieping Chen
LIGHT-related molecular network in the regulation of innate and adaptive immunity.
Immunologic research 2007;37(1):17-32.
2006: Xiaoyu Zhang; Haidong Dong; Wei Lin; Stephen Voss; Lucinda Hinkley; Melissa Westergren; Guoliang Tian; Daniel Berry; David Lewellen; Richard G Vile; Lieping Chen; Donna L Farber; Scott E Strome
Human bone marrow: a reservoir for "enhanced effector memory" CD8+ T cells with potent recall function.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(10):6730-7.
2006: Lieping Chen; T Wang; Ping Zhou; Lianli Ma; Dengping Yin; Jikun Shen; L Molinero; T Nozaki; T Phillips; S Uematsu; S Akira; Chyung-Ru Wang; R L Fairchild; Maria-Luisa Alegre; A Chong
TLR engagement prevents transplantation tolerance.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2006;6(10):2282-91.
2006: Xiaoyun Liu; Tim Martineau; Lieping Chen; Shaokang Zhan; Shenglan Tang
Does decentralisation improve human resource management in the health sector? A case study from China.
Social science & medicine (1982) 2006;63(7):1836-45.
2006: Yonglian Sun; Sarah E Blink; Wenhua Liu; Youjin Lee; Bohao Chen; Julian Solway; Joel Weinstock; Lieping Chen; Yang-Xin Fu
Inhibition of Th2-mediated allergic airway inflammatory disease by CD137 costimulation.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(2):814-21.
2006: Helmut R Salih; Sabine Wintterle; Matthias Krusch; Antje Kroner; Yu-Hwa Huang; Lieping Chen; Heinz Wiendl
The role of leukemia-derived B7-H1 (PD-L1) in tumor-T-cell interactions in humans.
Experimental hematology 2006;34(7):888-94.
2006: Ilona Kryczek; Shuang Wei; Linhua Zou; Gefeng Zhu; Peter Mottram; Huanbin Xu; Lieping Chen; Weiping Zou
Cutting edge: induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(1):40-4.
2006: SHENG YAO; Lieping Chen
Reviving exhausted T lymphocytes during chronic virus infection by B7-H1 blockade.
Trends in molecular medicine 2006;12(6):244-6.
2006: Ilona Kryczek; Linhua Zou; Paulo Rodriguez; Gefeng Zhu; Shuang Wei; Peter Mottram; Michael J Brumlik; Pui Cheng; Tyler J Curiel; Leann Myers; Andrew Lackner; Xavier Alvarez; Augusto Ochoa; Lieping Chen; Weiping Zou
B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma.
The Journal of experimental medicine 2006;203(4):871-81.
2006: Sudarshan Anand; Pu Wang; Kiyoshi Yoshimura; In-Hak Choi; Anja Hilliard; Youhai H Chen; Chyung-Ru Wang; Richard D Schulick; Andrew S Flies; Dallas B Flies; Gefeng Zhu; Yanhui Xu; Drew M Pardoll; Lieping Chen; Koji Tamada
Essential role of TNF family molecule LIGHT as a cytokine in the pathogenesis of hepatitis.
The Journal of clinical investigation 2006;116(4):1045-51.
2006: Koji Tamada; Lieping Chen
Renewed interest in cancer immunotherapy with the tumor necrosis factor superfamily molecules.
Cancer immunology, immunotherapy : CII 2006;55(4):355-62.
2006: Iñigo Tirapu; Eduardo Huarte; Cristiana Guiducci; Ainhoa Arina; Mikel Zaratiegui; Oihana Murillo; Alvaro Gonzalez; Carmen Berasain; Pedro Berraondo; Puri Fortes; Jesús Prieto; Mario P Colombo; Lieping Chen; Ignacio Melero
Low surface expression of B7-1 (CD80) is an immunoescape mechanism of colon carcinoma.
Cancer research 2006;66(4):2442-50.
2006: Seung-Jin Lee; Byeong-Churl Jang; Soo-Woong Lee; Young-Il Yang; Seong-Il Suh; Yeong-Min Park; Sangtaek Oh; Jae-Gook Shin; SHENG YAO; Lieping Chen; In-Hak Choi
Interferon regulatory factor-1 is prerequisite to the constitutive expression and IFN-gamma-induced upregulation of B7-H1 (CD274).
FEBS letters 2006;580(3):755-62.
2006: Mansour Mohamadzadeh; Lieping Chen; Gene Garrard Olinger; William D Pratt; Alan L Schmaljohn
Filoviruses and the balance of innate, adaptive, and inflammatory responses.
Viral immunology 2006;19(4):602-12.
2006: Dawei Ou; Xiaojie Wang; Daniel L Metzger; Ziliang Ao; Paolo Pozzilli; Roger F L James; Lieping Chen; Garth L Warnock
Suppression of human T-cell responses to beta-cells by activation of B7-H4 pathway.
Cell transplantation 2006;15(5):399-410.
2006: Dallas B Flies; Lieping Chen
Modulation of immune response by B7 family molecules in tumor microenvironments.
Immunological investigations 2006;35(3-4):395-418.
2005: R Houston Thompson; Michael D Gillett; John C Cheville; Christine M Lohse; Haidong Dong; W Scott Webster; Lieping Chen; Horst Zincke; Michael L Blute; Bradley C Leibovich; Eugene D Kwon
Costimulatory molecule B7-H1 in primary and metastatic clear cell renal cell carcinoma.
Cancer 2005;104(10):2084-91.
2005: Her Jun; Su K Seo; Hye-Young Jeong; Hyoun-Mi Seo; Gefeng Zhu; Lieping Chen; In-Hak Choi
B7-H1 (CD274) inhibits the development of herpetic stromal keratitis (HSK).
FEBS letters 2005;579(27):6259-64.
2005: Simone de Haij; Andrea M Woltman; Leendert A Trouw; Astrid C Bakker; Sylvia W A Kamerling; Sandra W van der Kooij; Lieping Chen; Richard A Kroczek; Mohamed R Daha; Cees van Kooten
Renal tubular epithelial cells modulate T-cell responses via ICOS-L and B7-H1.
Kidney international 2005;68(5):2091-102.
2005: JEAN KIM; Allen C Myers; Lieping Chen; Drew M Pardoll; Quynh-Ai Truong-Tran; Andrew Lane; John F McDyer; Lowella Fortuno; Robert P Schleimer
Constitutive and inducible expression of b7 family of ligands by human airway epithelial cells.
American journal of respiratory cell and molecular biology 2005;33(3):280-9.
2005: Hideto Tamura; Kazuo Dan; Koji Tamada; Kyoko Nakamura; Yumiko Shioi; Hideya Hyodo; Shengdian Wang; Haidong Dong; Lieping Chen; Kiyoyuki Ogata
Expression of functional B7-H2 and B7.2 costimulatory molecules and their prognostic implications in de novo acute myeloid leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(16):5708-17.
2005: Robert Vassallo; Koji Tamada; Julie S Lau; Paula R Kroening; Lieping Chen
Cigarette smoke extract suppresses human dendritic cell function leading to preferential induction of Th-2 priming.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(4):2684-91.
2005: Laura Arribillaga; Pablo Sarobe; Ainhoa Arina; Marta Gorraiz; Francisco Borrás-Cuesta; Juan Ruiz; Jesús Prieto; Lieping Chen; Ignacio Melero; Juan José Lasarte
Enhancement of CD4 and CD8 immunity by anti-CD137 (4-1BB) monoclonal antibodies during hepatitis C vaccination with recombinant adenovirus.
Vaccine 2005;23(27):3493-9.
2005: Tae Kwang Shin; Kiyoshi Yoshimura; Takako Shin; Emily Crafton; Haruo Tsuchiya; Franck Housseau; Haruhiko Koseki; Richard D Schulick; Lieping Chen; Drew M Pardoll
In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responses.
The Journal of experimental medicine 2005;201(10):1531-41.
2005: Tim Magnus; Bettina Schreiner; Thomas Korn; Carolyn Jack; Hong Guo; Jack Antel; Igal Ifergan; Lieping Chen; Felix Bischof; Amit Bar-Or; Heinz Wiendl
Microglial expression of the B7 family member B7 homolog 1 confers strong immune inhibition: implications for immune responses and autoimmunity in the CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(10):2537-46.
2005: Fumiya Hirano; Katsumi Kaneko; Hideto Tamura; Haidong Dong; Shengdian Wang; Masao Ichikawa; Cecilia Rietz; Dallas B Flies; Julie S Lau; Gefeng Zhu; Koji Tamada; Lieping Chen
Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity.
Cancer research 2005;65(3):1089-96.
2005: Liqing Wang; Christopher C Fraser; Kristine Kikly; Andrew D Wells; Rongxiang Han; Anthony J Coyle; Lieping Chen; Wayne W Hancock
B7-H3 promotes acute and chronic allograft rejection.
European journal of immunology 2005;35(2):428-38.
2005: Hui Shao; Yangxin Fu; Tianjiang Liao; Young Peng; Lieping Chen; Henry J Kaplan; Deming Sun
Anti-CD137 mAb treatment inhibits experimental autoimmune uveitis by limiting expansion and increasing apoptotic death of uveitogenic T cells.
Investigative ophthalmology & visual science 2005;46(2):596-603.
2005: Ignacio Melero; Ainhoa Arina; Lieping Chen
The many sounds of T lymphocyte silence.
Immunologic research 2005;33(2):135-47.
2005: Masao Ichikawa; Lieping Chen
Role of B7-H1 and B7-H4 molecules in down-regulating effector phase of T-cell immunity: novel cancer escaping mechanisms.
Frontiers in bioscience : a journal and virtual library 2005;10():2856-60.
2004: Dongdong Li; István Gál; Csaba Vermes; Maria-Luisa Alegre; Anita S Chong; Lieping Chen; Qing Shao; Vyacheslav Adarichev; Xuemei Xu; Tamas Koreny; Katalin Mikecz; Alison Finnegan; Tibor T Glant; Jian Zhang
Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(12):7135-9.
2004: R Houston Thompson; Michael D Gillett; John C Cheville; Christine M Lohse; Haidong Dong; W Scott Webster; Kent G Krejci; John R Lobo; Shomik Sengupta; Lieping Chen; Horst Zincke; Michael L Blute; Scott E Strome; Bradley C Leibovich; Eugene D Kwon
Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(49):17174-9.
2004: Liqun Luo; Andrei I Chapoval; Dallas B Flies; Gefeng Zhu; Fumiya Hirano; Shengdian Wang; Julie S Lau; Haidong Dong; Koji Tamada; Andrew S Flies; Yang Liu; Lieping Chen
B7-H3 enhances tumor immunity in vivo by costimulating rapid clonal expansion of antigen-specific CD8+ cytolytic T cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(9):5445-50.
2004: Bettina Schreiner; Meike Mitsdoerffer; Bernd C Kieseier; Lieping Chen; Hans-Peter Hartung; Michael Weller; Heinz Wiendl
Interferon-beta enhances monocyte and dendritic cell expression of B7-H1 (PD-L1), a strong inhibitor of autologous T-cell activation: relevance for the immune modulatory effect in multiple sclerosis.
Journal of neuroimmunology 2004;155(1-2):172-82.
2004: Tyler J Curiel; George Coukos; Linhua Zou; Xavier Alvarez; Pui Cheng; Peter Mottram; Melina Evdemon-Hogan; Tom Li Stephen; Lin Zhang; Matthew Burow; Yun Zhu; Shuang Wei; Ilona Kryczek; Ben Daniel; Alan Gordon; Leann Myers; Andrew Lackner; Mary L Disis; Keith L Knutson; Lieping Chen; Weiping Zou
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival.
Nature medicine 2004;10(9):942-9.
2004: Suresh Radhakrishnan; Loc Tan Nguyen; Bogoljub Ciric; Dallas B Flies; Virginia Van Keulen; Koji Tamada; Lieping Chen; Moses Rodriguez; Larry R Pease
Immunotherapeutic potential of B7-DC (PD-L2) cross-linking antibody in conferring antitumor immunity.
Cancer research 2004;64(14):4965-72.
2004: Shengdian Wang; Lieping Chen
Co-signaling molecules of the B7-CD28 family in positive and negative regulation of T lymphocyte responses.
Microbes and infection / Institut Pasteur 2004;6(8):759-66.
2004: Irene M Ward; Bernardo Reina-San-Martin; Andreea Olaru; Kay Minn; Koji Tamada; Julie S Lau; Marilia I Cascalho; Lieping Chen; André Nussenzweig; Ferenc Livak; Michel C Nussenzweig; Junjie Chen
53BP1 is required for class switch recombination.
The Journal of cell biology 2004;165(4):459-64.
2004: Iñigo Tirapu; Ainhoa Arina; Guillermo Mazzolini; Marina Duarte; Carlos Alfaro; Esperanza Feijoo; Cheng Qian; Lieping Chen; Jesus Prieto; Ignacio Melero
Improving efficacy of interleukin-12-transfected dendritic cells injected into murine colon cancer with anti-CD137 monoclonal antibodies and alloantigens.
International journal of cancer. Journal international du cancer 2004;110(1):51-60.
2004: Karin Schreiber; Ronald E Cannon; Theodore Karrison; Gabriele Beck-Engeser; Dezheng Huo; Raymond W Tennant; Heather Jensen; W Martin Kast; Thomas Krausz; Stephen C Meredith; Lieping Chen; Hans Schreiber
Strong synergy between mutant ras and HPV16 E6/E7 in the development of primary tumors.
Oncogene 2004;23(22):3972-9.
2004: Jin-Hu Guo; Hexige Saiyin; Y H Wei; Shuai Chen; Lieping Chen; Gang Bi; Li-Jie Ma; Guang-Jin Zhou; C Q Huang; Long Yu; L Dai
Expression of testis specific ankyrin repeat and SOCS box-containing 17 gene.
Archives of andrology 2004;50(3):155-61.
2004: Robert Vassallo; Lieping Chen
Selective suppression of dendritic cell functions by cigarette smoke extract.
Chest 2004;125(5 Suppl):107S.
2004: Lieping Chen
Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity.
Nature reviews. Immunology 2004;4(5):336-47.
2004: Xuewu Zhang; Jean-Claude D Schwartz; Xiaoling Guo; Sumeena Bhatia; Erhu Cao; Michael Lorenz; Michael Cammer; Lieping Chen; Zhong-Yin Zhang; Michael Edidin; Stanley G Nathenson; Steven C Almo
Structural and functional analysis of the costimulatory receptor programmed death-1.
Immunity 2004;20(3):337-47.
2004: Haidong Dong; Gefeng Zhu; Koji Tamada; Dallas B Flies; Jan M A van Deursen; Lieping Chen
B7-H1 determines accumulation and deletion of intrahepatic CD8(+) T lymphocytes.
Immunity 2004;20(3):327-36.
2004: Sumit K Subudhi; Ping Zhou; Lisa M Yerian; Robert K Chin; James C Lo; Robert A Anders; Yonglian Sun; Lieping Chen; Yang Wang; Maria-Luisa Alegre; Yang-Xin Fu
Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection.
The Journal of clinical investigation 2004;113(5):694-700.
2004: Shengdian Wang; Lieping Chen
T lymphocyte co-signaling pathways of the B7-CD28 family.
Cellular & molecular immunology 2004;1(1):37-42.
2004: Scott E Strome; Lieping Chen
Costimulation-based immunotherapy for head and neck cancer.
Current treatment options in oncology 2004;5(1):27-33.
2004: Pinku Mukherjee; Teresa L Tinder; Gargi D Basu; Latha B Pathangey; Lieping Chen; Sandra J Gendler
Therapeutic efficacy of MUC1-specific cytotoxic T lymphocytes and CD137 co-stimulation in a spontaneous breast cancer model.
Breast disease 2004;20():53-63.
2004: Sudarshan Anand; Lieping Chen
Control of autoimmune diseases by the B7-CD28 family molecules.
Current pharmaceutical design 2004;10(2):121-8.
2004: Cecilia Rietz; Lieping Chen
New B7 family members with positive and negative costimulatory function.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2004;4(1):8-14.
2004: Ryan A Wilcox; Koji Tamada; Dallas B Flies; Gefeng Zhu; Andrei I Chapoval; Bruce R Blazar; W Martin Kast; Lieping Chen
Ligation of CD137 receptor prevents and reverses established anergy of CD8+ cytolytic T lymphocytes in vivo.
Blood 2004;103(1):177-84.
2003: Iris Lee; Liqing Wang; Andrew D Wells; Qunrui Ye; Rongxiang Han; Martin E Dorf; William Kuziel; Barrett J Rollins; Lieping Chen; Wayne W Hancock
Blocking the monocyte chemoattractant protein-1/CCR2 chemokine pathway induces permanent survival of islet allografts through a programmed death-1 ligand-1-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(12):6929-35.
2003: Gerald P Morris; Lieping Chen; Yi chi M Kong
CD137 signaling interferes with activation and function of CD4+CD25+ regulatory T cells in induced tolerance to experimental autoimmune thyroiditis.
Cellular immunology 2003;226(1):20-9.
2003: Hideto Tamura; Kiyoyuki Ogata; Haidong Dong; Lieping Chen
Immunology of B7-H1 and its roles in human diseases.
International journal of hematology 2003;78(4):321-8.
2003: Sabine Wintterle; Bettina Schreiner; Meike Mitsdoerffer; Dagmar Schneider; Lieping Chen; Richard Meyermann; Michael Weller; Heinz Wiendl
Expression of the B7-related molecule B7-H1 by glioma cells: a potential mechanism of immune paralysis.
Cancer research 2003;63(21):7462-7.
2003: In-Hak Choi; Gefeng Zhu; Gabriel L Sica; Scott E Strome; John C Cheville; Julie S Lau; Yuwen Zhu; Dallas B Flies; Koji Tamada; Lieping Chen
Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(9):4650-4.
2003: Takanori Kanai; Teruji Totsuka; Koji Uraushihara; Shin Makita; Tetsuya Nakamura; Kazutaka Koganei; Tsuneo Fukushima; Hisaya Akiba; Hideo Yagita; Ko Okumura; Utako Machida; Hideyuki Iwai; Miyuki Azuma; Lieping Chen; Mamoru Watanabe
Blockade of B7-H1 suppresses the development of chronic intestinal inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(8):4156-63.
2003: Scott E Strome; Haidong Dong; Hideto Tamura; Stephen G Voss; Dallas B Flies; Koji Tamada; Diva R Salomao; John Cheville; Fumiya Hirano; Wei Lin; Jan L Kasperbauer; Karla V Ballman; Lieping Chen
B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma.
Cancer research 2003;63(19):6501-5.
2003: Heinz Wiendl; Meike Mitsdoerffer; Dagmar Schneider; Lieping Chen; Hanns Lochmüller; Arthur Melms; Michael Weller
Human muscle cells express a B7-related molecule, B7-H1, with strong negative immune regulatory potential: a novel mechanism of counterbalancing the immune attack in idiopathic inflammatory myopathies.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(13):1892-4.
2003: Govindarajan Rajagopalan; Yogish C Kudva; Lieping Chen; Li Wen; Chella S David
Autoimmune diabetes in HLA-DR3/DQ8 transgenic mice expressing the co-stimulatory molecule B7-1 in the beta cells of islets of Langerhans.
International immunology 2003;15(9):1035-44.
2003: Pornpan Youngnak; Yuko Kozono; Haruo Kozono; Hideyuki Iwai; Noriko Otsuki; Hisayo Jin; Ken Omura; Hideo Yagita; Drew M Pardoll; Lieping Chen; Miyuki Azuma
Differential binding properties of B7-H1 and B7-DC to programmed death-1.
Biochemical and biophysical research communications 2003;307(3):672-7.
2003: Tae Kwang Shin; Gene Kennedy; Kevin Gorski; Haruo Tsuchiya; Haruhiko Koseki; Miyuki Azuma; Hideo Yagita; Lieping Chen; Jonathan D Powell; Drew M Pardoll; Franck Housseau
Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor.
The Journal of experimental medicine 2003;198(1):31-8.
2003: Yuwen Zhu; Lieping Chen
Cancer therapeutic monoclonal antibodies targeting lymphocyte co-stimulatory pathways.
Current opinion in investigational drugs (London, England : 2000) 2003;4(6):691-5.
2003: Gabriel L Sica; In-Hak Choi; Gefeng Zhu; Koji Tamada; Shengdian Wang; Hideto Tamura; Andrei I Chapoval; Dallas B Flies; Jürgen Bajorath; Lieping Chen
B7-H4, a molecule of the B7 family, negatively regulates T cell immunity.
Immunity 2003;18(6):849-61.
2003: Shengdian Wang; Jürgen Bajorath; Dallas B Flies; Haidong Dong; Tasuku Honjo; Lieping Chen
Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction.
The Journal of experimental medicine 2003;197(9):1083-91.
2003: Dallas B Flies; Lieping Chen
A simple and rapid vortex method for preparing antigen/adjuvant emulsions for immunization.
Journal of immunological methods 2003;276(1-2):239-42.
2003: Haidong Dong; Lieping Chen
B7-H1 pathway and its role in the evasion of tumor immunity.
Journal of molecular medicine (Berlin, Germany) 2003;81(5):281-7.
2003: Eric C Weinman; Patrick C Roche; Jan L Kasperbauer; Steve S Cha; Daniel J Sargent; John Cheville; Linda M Murphy; Lieping Chen; Peter J Wettstein; Bobbie S Gostout; Soldano Ferrone; Scott E Strome
Characterization of antigen processing machinery and Survivin expression in tonsillar squamous cell carcinoma.
Cancer 2003;97(9):2203-11.
2003: Shin Kurosawa; Allen C Myers; Lieping Chen; Shengdian Wang; Jian Ni; James R Plitt; Nicola M Heller; Bruce S Bochner; Robert P Schleimer
Expression of the costimulatory molecule B7-H2 (inducible costimulator ligand) by human airway epithelial cells.
American journal of respiratory cell and molecular biology 2003;28(5):563-73.
2003: Tyler J Curiel; Shuang Wei; Haidong Dong; Xavier Alvarez; Pui Cheng; Peter Mottram; Roman Krzysiek; Keith L Knutson; Ben Daniel; Maria Carla Zimmermann; Odile David; Matthew Burow; Alan Gordon; Nina Dhurandhar; Leann Myers; Ruth Berggren; Akseli Hemminki; Ronald D Alvarez; Dominique Emilie; David T Curiel; Lieping Chen; Weiping Zou
Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity.
Nature medicine 2003;9(5):562-7.
2003: Margaret G Petroff; Lieping Chen; Teresa A Phillips; Dagmar Azzola; Peter Sedlmayr; Joan S Hunt
B7 family molecules are favorably positioned at the human maternal-fetal interface.
Biology of reproduction 2003;68(5):1496-504.
2003: Daria Trabattoni; Marina Saresella; Mara Biasin; Adriano Boasso; Luca Piacentini; Pasquale Ferrante; Haidong Dong; Renato Maserati; Gene M Shearer; Lieping Chen; Mario Clerici
B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression.
Blood 2003;101(7):2514-20.
2003: Suresh Radhakrishnan; Loc T Nguyen; Bogoljub Ciric; Daren R Ure; Bin Zhou; Koji Tamada; Haidong Dong; Su-Yi Tseng; Tae Kwang Shin; Drew M Pardoll; Lieping Chen; Robert A Kyle; Moses Rodriguez; Larry R Pease
Naturally occurring human IgM antibody that binds B7-DC and potentiates T cell stimulation by dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(4):1830-8.
2003: Haidong Dong; Scott E Strome; Eric L Matteson; Kevin G Moder; Dallas B Flies; Gefeng Zhu; Hideto Tamura; Colin L W Driscoll; Lieping Chen
Costimulating aberrant T cell responses by B7-H1 autoantibodies in rheumatoid arthritis.
The Journal of clinical investigation 2003;111(3):363-70.
2002: Xiaohong Li; Xiaodong Li; Jianyong Huang; Lixin Wei; Lieping Chen; Mengchao Wu; Yajun Guo
[Antitumor immunity elicited by 4-1BBL gene transfected Hepa1-6 in vivo].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 2002;10(6):409-12.
2002: Yonglian Sun; Helen Min Chen; Sumit K Subudhi; Jonathan Chen; Rima Koka; Lieping Chen; Yang-Xin Fu
Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease.
Nature medicine 2002;8(12):1405-13.
2002: Loc T Nguyen; Suresh Radhakrishnan; Bogoljub Ciric; Koji Tamada; Tae Kwang Shin; Drew M Pardoll; Lieping Chen; Moses Rodriguez; Larry R Pease
Cross-linking the B7 family molecule B7-DC directly activates immune functions of dendritic cells.
The Journal of experimental medicine 2002;196(10):1393-8.
2002: Ryan A Wilcox; Koji Tamada; Scott E Strome; Lieping Chen
Signaling through NK cell-associated CD137 promotes both helper function for CD8+ cytolytic T cells and responsiveness to IL-2 but not cytolytic activity.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(8):4230-6.
2002: Ryan A Wilcox; Dallas B Flies; Hao Wang; Koji Tamada; Aaron J Johnson; Larry R Pease; Moses Rodriguez; Yajun Guo; Lieping Chen
Impaired infiltration of tumor-specific cytolytic T cells in the absence of interferon-gamma despite their normal maturation in lymphoid organs during CD137 monoclonal antibody therapy.
Cancer research 2002;62(15):4413-8.
2002: Haidong Dong; Scott E Strome; Diva R Salomao; Hideto Tamura; Fumiya Hirano; Dallas B Flies; Patrick C Roche; Jun Lu; Gefeng Zhu; Koji Tamada; Vanda A Lennon; Esteban Celis; Lieping Chen
Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion.
Nature medicine 2002;8(8):793-800.
2002: Andrei I Chapoval; Gefeng Zhu; Lieping Chen
Immunoglobulin fusion proteins as a tool for evaluation of T-cell costimulatory molecules.
Molecular biotechnology 2002;21(3):259-64.
2002: Kenneth F May; Lieping Chen; Pan Zheng; Yang Liu
Anti-4-1BB monoclonal antibody enhances rejection of large tumor burden by promoting survival but not clonal expansion of tumor-specific CD8+ T cells.
Cancer research 2002;62(12):3459-65.
2002: Tsui-Ling Sherry Hsu; Yung-Chi Chang; Siu-Ju Chen; Yong-Jun Liu; Allen W Chiu; Chung-Ching Chio; Lieping Chen; Shie-Liang Hsieh
Modulation of dendritic cell differentiation and maturation by decoy receptor 3.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(10):4846-53.
2002: Koji Tamada; Jian Ni; Gefeng Zhu; Michele Fiscella; Baiqin Teng; Jan M A van Deursen; Lieping Chen
Cutting edge: selective impairment of CD8+ T cell function in mice lacking the TNF superfamily member LIGHT.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(10):4832-5.
2002: Ryan A Wilcox; Andrei I Chapoval; Kevin Gorski; Mizuto Otsuji; Tae Kwang Shin; Dallas B Flies; Koji Tamada; Robert S Mittler; Haruo Tsuchiya; Drew M Pardoll; Lieping Chen
Cutting edge: Expression of functional CD137 receptor by dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(9):4262-7.
2002: Shengdian Wang; Gefeng Zhu; Koji Tamada; Lieping Chen; Jürgen Bajorath
Ligand binding sites of inducible costimulator and high avidity mutants with improved function.
The Journal of experimental medicine 2002;195(8):1033-41.
2002: Lieping Chen
Antibody gene therapy: old wine in a new bottle.
Nature medicine 2002;8(4):333-4.
2002: Ryan A Wilcox; Lieping Chen
Immunotherapy of human papillomavirus-associated malignancies and the challenges posed by T-cell tolerance.
Frontiers in bioscience : a journal and virtual library 2002;7():d853-71.
2002: Scott E Strome; Stephen Voss; Ryan Wilcox; TAMEKIA WAKEFIELD; Koji Tamada; Dallas B Flies; Andrei I Chapoval; Jun Lu; Jan L Kasperbauer; Douglas Padley; Richard Vile; Dennis A Gastineau; Peter J Wettstein; Lieping Chen
Strategies for antigen loading of dendritic cells to enhance the antitumor immune response.
Cancer research 2002;62(6):1884-9.
2002: Ryan A Wilcox; Dallas B Flies; Gefeng Zhu; Aaron J Johnson; Koji Tamada; Andrei I Chapoval; Scott E Strome; Larry R Pease; Lieping Chen
Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors.
The Journal of clinical investigation 2002;109(5):651-9.
2002: Scott E Strome; Elizabeth Martin; Dallas B Flies; Dianne Khurana; Diva R Salomao; Koji Tamada; Andrei I Chapoval; Jan L Kasperbauer; Kerry D Olsen; Lieping Chen
Reassessment of CD62L as a marker of pre-effector T cells in the tumor draining lymph nodes of head and neck cancer patients.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2002;126(2):180-7.
2002: Koji Tamada; Hideto Tamura; Dallas B Flies; Yang-Xin Fu; Esteban Celis; Larry R Pease; Bruce R Blazar; Lieping Chen
Blockade of LIGHT/LTbeta and CD40 signaling induces allospecific T cell anergy, preventing graft-versus-host disease.
The Journal of clinical investigation 2002;109(4):549-57.
2002: Yonglian Sun; Xiaoqi Lin; Helen Min Chen; Qiang Wu; Sumit K Subudhi; Lieping Chen; Yang-Xin Fu
Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(3):1457-65.
2002: Scott E Strome; Koji Kawakami; Danielle Alejandro; Stephen Voss; Jan L Kasperbauer; Diva R Salomao; Lieping Chen; Richard A Maki; Raj K Puri
Interleukin 4 receptor-directed cytotoxin therapy for human head and neck squamous cell carcinoma in animal models.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(1):281-6.
2001: Hui Xu; Ajay Sharma; Lieping Chen; C Harrison; Y Wei; Anita S Chong; John S Logan; Guerard W Byrne; A Shama
The structure of anti-Gal immunoglobulin genes in naïve and stimulated Gal knockout mice.
Transplantation 2001;72(11):1817-25.
2001: Jun Wang; James C Lo; Amy Foster; Ping Yu; Helen Min Chen; Youli Wang; Koji Tamada; Lieping Chen; Yang-Xin Fu
The regulation of T cell homeostasis and autoimmunity by T cell-derived LIGHT.
The Journal of clinical investigation 2001;108(12):1771-80.
2001: Jun Wang; Taehoon Chun; James C Lo; Qiang Wu; Youli Wang; Amy Foster; K Roca; M Chen; Koji Tamada; Lieping Chen; Chyung-Ru Wang; Yang-Xin Fu
The critical role of LIGHT, a TNF family member, in T cell development.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(9):5099-105.
2001: Gefeng Zhu; Dallas B Flies; Koji Tamada; Y Sun; M Rodriguez; Y X Fu; Lieping Chen
Progressive depletion of peripheral B lymphocytes in 4-1BB (CD137) ligand/I-Ealpha)-transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(5):2671-6.
2001: H Tamura; Haidong Dong; Gefeng Zhu; Gabriel L Sica; Dallas B Flies; Koji Tamada; Lieping Chen
B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function.
Blood 2001;97(6):1809-16.
2001: Ignacio Melero; Guillermo Mazzolini; Inigo Narvaiza; Cheng Qian; Lieping Chen; J Prieto
IL-12 gene therapy for cancer: in synergy with other immunotherapies.
Trends in immunology 2001;22(3):113-5.
2001: Andrei I Chapoval; J Ni; Julie S Lau; Ryan A Wilcox; Dallas B Flies; D Liu; Haidong Dong; Gabriel L Sica; Gefeng Zhu; Koji Tamada; Lieping Chen
B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production.
Nature immunology 2001;2(3):269-74.
2000: Shengdian Wang; Gefeng Zhu; Andrei I Chapoval; Haidong Dong; Koji Tamada; J Ni; Lieping Chen
Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS.
Blood 2000;96(8):2808-13.
2000: Koji Tamada; Lieping Chen
T lymphocyte costimulatory molecules in host defense and immunologic diseases.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2000;85(3):164-75; quiz 175-7.
2000: Scott E Strome; B Martin; Dallas B Flies; Koji Tamada; Andrei I Chapoval; D J Sargent; S Shu; Lieping Chen
Enhanced therapeutic potential of adoptive immunotherapy by in vitro CD28/4-1BB costimulation of tumor-reactive T cells against a poorly immunogenic, major histocompatibility complex class I-negative A9P melanoma.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2000;23(4):430-7.
2000: Jing Yang; Wei Bian; X Gao; Lieping Chen; Naihe Jing
Nestin expression during mouse eye and lens development.
Mechanisms of development 2000;94(1-2):287-91.
2000: Koji Tamada; K Shimozaki; Andrei I Chapoval; Y Zhai; J Su; S F Chen; S L Hsieh; S Nagata; J Ni; Lieping Chen
LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(8):4105-10.
2000: Andrei I Chapoval; Koji Tamada; Lieping Chen
In vitro growth inhibition of a broad spectrum of tumor cell lines by activated human dendritic cells.
Blood 2000;95(7):2346-51.
2000: Koji Tamada; K Shimozaki; Andrei I Chapoval; Gefeng Zhu; Gabriel L Sica; Dallas B Flies; T Boone; H Hsu; Y X Fu; S Nagata; J Ni; Lieping Chen
Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway.
Nature medicine 2000;6(3):283-9.
2000: Andrei I Chapoval; Gefeng Zhu; Lieping Chen
Immunoglobulin fusion proteins as a tool for evaluation of T-cell costimulatory molecules.
Methods in molecular medicine 2000;45():247-55.
2000: G Sica; Lieping Chen
Modulation of the immune response through 4-1BB.
Advances in experimental medicine and biology 2000;465():355-62.
1999: Haidong Dong; Gefeng Zhu; Koji Tamada; Lieping Chen
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion.
Nature medicine 1999;5(12):1365-9.
1999: S Hu; Koji Tamada; J Ni; Claudius Vincenz; Lieping Chen
Characterization of TNFRSF19, a novel member of the tumor necrosis factor receptor superfamily.
Genomics 1999;62(1):103-7.
1999: Aaron J Johnson; M Kariuki Njenga; Michael J Hansen; ST Kuhns; Lieping Chen; Moses Rodriguez; Larry R Pease
Prevalent class I-restricted T-cell response to the Theiler's virus epitope Db:VP2121-130 in the absence of endogenous CD4 help, tumor necrosis factor alpha, gamma interferon, perforin, or costimulation through CD28.
Journal of virology 1999;73(5):3702-8.
1999: Lieping Chen
Mimotopes of cytolytic T lymphocytes in cancer immunotherapy.
Current opinion in immunology 1999;11(2):219-22.
1999: G Sica; Lieping Chen
Biochemical and immunological characteristics of 4-1BB (CD137) receptor and ligand and potential applications in cancer therapy.
Archivum immunologiae et therapiae experimentalis 1999;47(5):275-9.
1999: Lieping Chen; C Boomershine; Tianyi Wang; William P Lafuse; Bruce S Zwilling
Synergistic interaction of catecholamine hormones and Mycobacterium avium results in the induction of interleukin-10 mRNA expression by murine peritoneal macrophages.
Journal of neuroimmunology 1999;93(1-2):149-55.
1998: Lieping Chen
Overcoming T cell ignorance by providing costimulation. Implications for the immune response against cancer.
Advances in experimental medicine and biology 1998;451():159-65.
1998: Lieping Chen
Immunological ignorance of silent antigens as an explanation of tumor evasion.
Immunology today 1998;19(1):27-30.
1997: M Wick; Purnima Dubey; H Koeppen; CT Siegel; PE Fields; Lieping Chen; Jeffrey A Bluestone; Hans Schreiber
Antigenic cancer cells grow progressively in immune hosts without evidence for T cell exhaustion or systemic anergy.
The Journal of experimental medicine 1997;186(2):229-38.
1997: M Maric; Lieping Chen; B Sherry; Yang Liu
A mechanism for selective recruitment of CD8 T cells into B7-1-transfected plasmacytoma: role of macrophage-inflammatory protein 1alpha.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(1):360-8.
1997: G Yang; Karl Erik Hellström; Lieping Chen
The role of B7-2 (CD86) in tumour immunity.
Expert opinion on investigational drugs 1997;6(6):677-84.
1997: I Melero; M C Singhal; P McGowan; Harald S Haugen; J Blake; K E Hellstrom; G Yang; CH Clegg; Lieping Chen
Immunological ignorance of an E7-encoded cytolytic T-lymphocyte epitope in transgenic mice expressing the E7 and E6 oncogenes of human papillomavirus type 16.
Journal of virology 1997;71(5):3998-4004.
1997: Lieping Chen
Manipulation of T cell response to tumors by targeting on costimulatory pathway.
Leukemia 1997;11 Suppl 3():567-9.
1996: Falk Weih; Rolf-Peter Ryseck; Lieping Chen; R Bravo
Apoptosis of nur77/N10-transgenic thymocytes involves the Fas/Fas ligand pathway.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(11):5533-8.
1996: Karl Erik Hellström; Lieping Chen; Ingegerd Hellström
Costimulation of T-cell-mediated tumor immunity.
Cancer chemotherapy and pharmacology 1996;38 Suppl():S40-1.
1995: L Ramarathinam; Supria Sarma; M Maric; M Zhao; G Yang; Lieping Chen; Yang Liu
Multiple lineages of tumors express a common tumor antigen, P1A, but they are not cross-protected.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(11):5323-9.
1995: K E Hellström; I Hellström; Lieping Chen
Can co-stimulated tumor immunity be therapeutically efficacious?
Immunological reviews 1995;145():123-45.
1994: L Zhang; Karl Erik Hellström; Lieping Chen
Luciferase activity as a marker of tumor burden and as an indicator of tumor response to antineoplastic therapy in vivo.
Clinical & experimental metastasis 1994;12(2):87-92.
1993: K E Hellström; I Hellström; P Linsley; Lieping Chen
On the role of costimulation in tumor immunity.
Annals of the New York Academy of Sciences 1993;690():225-30.
1991: Lieping Chen; E K Thomas; Shiu-Lok Hu; Ingegerd Hellström; Karl Erik Hellström
Human papillomavirus type 16 nucleoprotein E7 is a tumor rejection antigen.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(1):110-4.