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Philip Chen

Research Profile

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Philip E Chen; Mick L Errington; Matthias Kneussel; Guiquan Chen; Alexander Annala; York H Rudhard; Georg F Rast; Christian G Specht; Cezar M Tigaret; Mohammed A Nassar; Richard G M Morris; T V P Bliss; Ralf Schoepfer
Behavioral deficits and subregion-specific suppression of LTP in mice expressing a population of mutant NMDA receptors throughout the hippocampus.
Hannah J Otton; Ariane Janssen; Timothy O'Leary; Philip E Chen; David J A Wyllie
Inhibition of rat recombinant GluN1/GluN2A and GluN1/GluN2B NMDA receptors by ethanol at concentrations based on the US/UK drink-drive limit.
C A Puddifoot; Philip E Chen; R Schoepfer; David J A Wyllie
Pharmacological characterization of recombinant NR1/NR2A NMDA receptors with truncated and deleted carboxy termini expressed in Xenopus laevis oocytes.

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All Publications

2009: Philip E Chen; Mick L Errington; Matthias Kneussel; Guiquan Chen; Alexander Annala; York H Rudhard; Georg F Rast; Christian G Specht; Cezar M Tigaret; Mohammed A Nassar; Richard G M Morris; T V P Bliss; Ralf Schoepfer
Behavioral deficits and subregion-specific suppression of LTP in mice expressing a population of mutant NMDA receptors throughout the hippocampus.
Learning & memory (Cold Spring Harbor, N.Y.) 2009;16(10):635-44.
2009: Hannah J Otton; Ariane Janssen; Timothy O'Leary; Philip E Chen; David J A Wyllie
Inhibition of rat recombinant GluN1/GluN2A and GluN1/GluN2B NMDA receptors by ethanol at concentrations based on the US/UK drink-drive limit.
European journal of pharmacology 2009;614(1-3):14-21.
2009: C A Puddifoot; Philip E Chen; R Schoepfer; David J A Wyllie
Pharmacological characterization of recombinant NR1/NR2A NMDA receptors with truncated and deleted carboxy termini expressed in Xenopus laevis oocytes.
British journal of pharmacology 2009;156(3):509-18.
2008: David C Wrighton; Edward J Baker; Philip E Chen; David J A Wyllie
Mg2+ and memantine block of rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes.
The Journal of physiology 2008;586(1):211-25.
2008: Philip E Chen; Matthew T Geballe; Elyse Katz; Kevin Erreger; Matthew R Livesey; Kate K O'Toole; Phuong Le; C Justin Lee; James P Snyder; Stephen F Traynelis; David J A Wyllie
Modulation of glycine potency in rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes.
The Journal of physiology 2008;586(1):227-45.
2007: Kevin Erreger; Matthew T Geballe; Anders Skov Kristensen; Philip E Chen; Kasper B Hansen; C Justin Lee; Hongjie Yuan; Phuong Le; Polina Lyuboslavsky; Nicola Micale; Lars Jørgensen; Rasmus P Clausen; David J A Wyllie; James P Snyder; Stephen F Traynelis
Subunit-specific agonist activity at NR2A-, NR2B-, NR2C-, and NR2D-containing N-methyl-D-aspartate glutamate receptors.
Molecular pharmacology 2007;72(4):907-20.
2007: David J A Wyllie; Philip E Chen
Taking the time to study competitive antagonism.
British journal of pharmacology 2007;150(5):541-51.
2007: Thomas M Wishart; Stephen H-F MacDonald; Philip E Chen; Michael Shipston; Michael P Coleman; Thomas H Gillingwater; Richard R Ribchester
Design of a novel quantitative PCR (QPCR)-based protocol for genotyping mice carrying the neuroprotective Wallerian degeneration slow (Wlds) gene.
Molecular neurodegeneration 2007;2():21.
2006: Pamela A Frizelle; Philip E Chen; David J A Wyllie
Equilibrium constants for (R)-[(S)-1-(4-bromo-phenyl)-ethylamino]-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-methyl]-phosphonic acid (NVP-AAM077) acting at recombinant NR1/NR2A and NR1/NR2B N-methyl-D-aspartate receptors: Implications for studies of synaptic transmission.
Molecular pharmacology 2006;70(3):1022-32.
2006: David J A Wyllie; Alexander R Johnston; Diane Lipscombe; Philip E Chen
Single-channel analysis of a point mutation of a conserved serine residue in the S2 ligand-binding domain of the NR2A NMDA receptor subunit.
The Journal of physiology 2006;574(Pt 2):477-89.
2006: Philip E Chen; David J A Wyllie
Pharmacological insights obtained from structure-function studies of ionotropic glutamate receptors.
British journal of pharmacology 2006;147(8):839-53.
2006: Thomas H Gillingwater; Thomas M Wishart; Philip E Chen; Jane E Haley; Kevin Robertson; Stephen H-F MacDonald; Susan Middleton; Kolja Wawrowski; Michael Shipston; Shlomo Melmed; David J A Wyllie; Paul A Skehel; Michael P Coleman; Richard R Ribchester
The neuroprotective WldS gene regulates expression of PTTG1 and erythroid differentiation regulator 1-like gene in mice and human cells.
Human molecular genetics 2006;15(4):625-35.
2005: Philip E Chen; Matthew T Geballe; Phillip J Stansfeld; Alexander R Johnston; Hongjie Yuan; Amanda L Jacob; James P Snyder; Stephen F Traynelis; David J A Wyllie
Structural features of the glutamate binding site in recombinant NR1/NR2A N-methyl-D-aspartate receptors determined by site-directed mutagenesis and molecular modeling.
Molecular pharmacology 2005;67(5):1470-84.
2004: Philip E Chen; Alexander R Johnston; M H Selina Mok; Ralf Schoepfer; David J A Wyllie
Influence of a threonine residue in the S2 ligand binding domain in determining agonist potency and deactivation rate of recombinant NR1a/NR2D NMDA receptors.
The Journal of physiology 2004;558(Pt 1):45-58.
2004: Kevin Erreger; Philip E Chen; David J A Wyllie; Stephen F Traynelis
Glutamate receptor gating.
Critical reviews in neurobiology 2004;16(3):187-224.
2003: York Rudhard; Matthias Kneussel; Mohammed A Nassar; Georg F Rast; Alexander Annala; Philip E Chen; Cezar M Tigaret; Isabel Dean; Jürgen Roes; Alasdair J Gibb; Stephen P Hunt; Ralf Schoepfer
Absence of Whisker-related pattern formation in mice with NMDA receptors lacking coincidence detection properties and calcium signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(6):2323-32.
2002: Philip E Chen; Christian G Specht; Richard G M Morris; Ralf Schoepfer
Spatial learning is unimpaired in mice containing a deletion of the alpha-synuclein locus.
The European journal of neuroscience 2002;16(1):154-8.
1998: L C Anson; Philip E Chen; David J A Wyllie; David Colquhoun; Ralf Schoepfer
Identification of amino acid residues of the NR2A subunit that control glutamate potency in recombinant NR1/NR2A NMDA receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(2):581-9.