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Pojen Chen

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Wenfeng Tan; Hui Wu; Jian Zhao; Lezlie A Derber; David M Lee; Nancy A Shadick; Doyt L Conn; Edwin A Smith; Vivian H Gersuk; Gerald Nepom; Larry W Moreland; Daniel E Furst; Susan D Thompson; Beth L Jonas; V Michael Holers; David N Glass; Pojen P Chen; S Louis Bridges; Michael E Weinblatt; Harold E Paulus; Betty P Tsao
A functional RANKL polymorphism associated with younger age at onset of rheumatoid arthritis.
M Anthony Moody; Hua-Xin Liao; S Munir Alam; Richard M Scearce; M Kelly Plonk; Daniel M Kozink; Mark S Drinker; Ruijun Zhang; Shi-Mao Xia; Laura L Sutherland; Georgia D Tomaras; Ian P Giles; John C Kappes; Christina Ochsenbauer-Jambor; Tara G Edmonds; Melina Soares; Gustavo Barbero; Donald N Forthal; Gary Landucci; Connie Chang; Steven W King; Anita Kavlie; Thomas N Denny; Kwan-Ki Hwang; Pojen P Chen; Philip E Thorpe; David C Montefiori; Barton F Haynes
Anti-phospholipid human monoclonal antibodies inhibit CCR5-tropic HIV-1 and induce beta-chemokines.
Jacob H Rand; Xiao-Xuan Wu; Anthony S Quinn; Anthony W Ashton; Pojen P Chen; James J Hathcock; Harry A M Andree; Douglas J Taatjes
Hydroxychloroquine protects the annexin A5 anticoagulant shield from disruption by antiphospholipid antibodies: evidence for a novel effect for an old antimalarial drug.

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All Publications

2010: Wenfeng Tan; Hui Wu; Jian Zhao; Lezlie A Derber; David M Lee; Nancy A Shadick; Doyt L Conn; Edwin A Smith; Vivian H Gersuk; Gerald Nepom; Larry W Moreland; Daniel E Furst; Susan D Thompson; Beth L Jonas; V Michael Holers; David N Glass; Pojen P Chen; S Louis Bridges; Michael E Weinblatt; Harold E Paulus; Betty P Tsao
A functional RANKL polymorphism associated with younger age at onset of rheumatoid arthritis.
Arthritis and rheumatism 2010;62(10):2864-75.
2010: M Anthony Moody; Hua-Xin Liao; S Munir Alam; Richard M Scearce; M Kelly Plonk; Daniel M Kozink; Mark S Drinker; Ruijun Zhang; Shi-Mao Xia; Laura L Sutherland; Georgia D Tomaras; Ian P Giles; John C Kappes; Christina Ochsenbauer-Jambor; Tara G Edmonds; Melina Soares; Gustavo Barbero; Donald N Forthal; Gary Landucci; Connie Chang; Steven W King; Anita Kavlie; Thomas N Denny; Kwan-Ki Hwang; Pojen P Chen; Philip E Thorpe; David C Montefiori; Barton F Haynes
Anti-phospholipid human monoclonal antibodies inhibit CCR5-tropic HIV-1 and induce beta-chemokines.
The Journal of experimental medicine 2010;207(4):763-76.
2010: Jacob H Rand; Xiao-Xuan Wu; Anthony S Quinn; Anthony W Ashton; Pojen P Chen; James J Hathcock; Harry A M Andree; Douglas J Taatjes
Hydroxychloroquine protects the annexin A5 anticoagulant shield from disruption by antiphospholipid antibodies: evidence for a novel effect for an old antimalarial drug.
Blood 2010;115(11):2292-9.
2010: Pojen P Chen; Ian Giles
Antibodies to serine proteases in the antiphospholipid syndrome.
Current rheumatology reports 2010;12(1):45-52.
2010: Yao-Hsu Yang; Chun-Jung Chang; Ya-Hui Chuang; Hui-Yao Hsu; Pojen P Chen; Bor-Luen Chiang
Identification of anti-prothrombin antibodies in the anti-phospholipid syndrome that display the prothrombinase activity.
Rheumatology (Oxford, England) 2010;49(1):34-42.
2009: Kaleo Ede; Kwan-Ki Hwang; Chen-Ching Wu; Meifang Wu; Yao-Hsu Yang; Wei-Shiang Lin; Daniel Chien; Pei-Chih Chen; Betty P Tsao; Deborah K McCurdy; Pojen P Chen
Plasmin immunization preferentially induces potentially prothrombotic IgG anticardiolipin antibodies in MRL/MpJ mice.
Arthritis and rheumatism 2009;60(10):3108-17.
2009: Yao-Hsu Yang; Daniel Chien; Meifang Wu; John FitzGerald; Jennifer M Grossman; Bevra H Hahn; Kwan-Ki Hwang; Pojen P Chen
Novel autoantibodies against the activated coagulation factor IX (FIXa) in the antiphospholipid syndrome that interpose the FIXa regulation by antithrombin.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(3):1674-80.
2008: Jacob H Rand; Xiao-Xuan Wu; Anthony S Quinn; Pojen P Chen; James J Hathcock; Douglas J Taatjes
Hydroxychloroquine directly reduces the binding of antiphospholipid antibody-beta2-glycoprotein I complexes to phospholipid bilayers.
Blood 2008;112(5):1687-95.
2008: Silvia S Pierangeli; Pojen P Chen; Elena Raschi; Silvia Scurati; Carlo E Grossi; Maria Orietta Borghi; Ivan Palomo; E Nigel Harris; Pier Luigi Meroni
Antiphospholipid antibodies and the antiphospholipid syndrome: pathogenic mechanisms.
Seminars in thrombosis and hemostasis 2008;34(3):236-50.
2007: Wei-Shiang Lin; Pei-Chih Chen; Cheng-De Yang; EunJung Cho; Bevra H Hahn; Jennifer Grossman; Kwan-Ki Hwang; Pojen P Chen
Some antiphospholipid antibodies recognize conformational epitopes shared by beta2-glycoprotein I and the homologous catalytic domains of several serine proteases.
Arthritis and rheumatism 2007;56(5):1638-47.
2007: Xiao-xiang Chen; Yue-ying Gu; Shu-Jie Li; Jie Qian; Kwan-Ki Hwang; Pojen P Chen; Shun-le Chen; Cheng-De Yang
Some plasmin-induced antibodies bind to cardiolipin, display lupus anticoagulant activity and induce fetal loss in mice.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(8):5351-6.
2006: Yao-Hsu Yang; Kwan-Ki Hwang; John FitzGerald; Jennifer M Grossman; Mihaela Taylor; Bevra H Hahn; Pojen P Chen
Antibodies against the activated coagulation factor X (FXa) in the antiphospholipid syndrome that interfere with the FXa inactivation by antithrombin.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(11):8219-25.
2006: Silvia S Pierangeli; Pojen P Chen; Emilio B González
Antiphospholipid antibodies and the antiphospholipid syndrome: an update on treatment and pathogenic mechanisms.
Current opinion in hematology 2006;13(5):366-75.
2005: Cai-Sheng Lu; Arash A Horizon; Kwan-Ki Hwang; John FitzGerald; Wei-Shiang Lin; Bevra H Hahn; Daniel J Wallace; Allan L Metzger; Michael H Weisman; Pojen P Chen
Identification of polyclonal and monoclonal antibodies against tissue plasminogen activator in the antiphospholipid syndrome.
Arthritis and rheumatism 2005;52(12):4018-27.
2004: Jacob H Rand; Xiao-Xuan Wu; Robert Lapinski; Waander L van Heerde; Chris P M Reutelingsperger; Pojen P Chen; Thomas L Ortel
Detection of antibody-mediated reduction of annexin A5 anticoagulant activity in plasmas of patients with the antiphospholipid syndrome.
Blood 2004;104(9):2783-90.
2004: Cheng-De Yang; Kwan-Ki Hwang; Weihong Yan; Kerry Gallagher; John FitzGerald; Jennifer M Grossman; Bevra H Hahn; Pojen P Chen
Identification of anti-plasmin antibodies in the antiphospholipid syndrome that inhibit degradation of fibrin.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(9):5765-73.
2003: Jacob H Rand; Xiao-Xuan Wu; Anthony S Quinn; Pojen P Chen; Keith R McCrae; Edwin G Bovill; Douglas J Taatjes
Human monoclonal antiphospholipid antibodies disrupt the annexin A5 anticoagulant crystal shield on phospholipid bilayers: evidence from atomic force microscopy and functional assay.
The American journal of pathology 2003;163(3):1193-200.
2003: Ian Giles; Joanna D Haley; Sylvia Nagl; David S Latchman; Pojen P Chen; Reginald U Chukwuocha; David A Isenberg; Anisur Rahman
Relative importance of different human aPL derived heavy and light chains in the binding of aPL to cardiolipin.
Molecular immunology 2003;40(1):49-60.
2003: Kwan-Ki Hwang; Cheng-De Yang; Weihong Yan; Jennifer M Grossman; Bevra H Hahn; Pojen P Chen
A thrombin-cross-reactive anticardiolipin antibody binds to and inhibits the anticoagulant function of activated protein C.
Arthritis and rheumatism 2003;48(6):1622-30.
2003: Sudha Visvanathan; jamie scott; Kwan-Ki Hwang; Michelle Banares; Jennifer M Grossman; Joan T Merrill; John FitzGerald; Reginald U Chukwuocha; Betty P Tsao; Bevra H Hahn; Pojen P Chen
Identification and characterization of a peptide mimetic that may detect a species of disease-associated anticardiolipin antibodies in patients with the antiphospholipid syndrome.
Arthritis and rheumatism 2003;48(3):737-45.
2003: Mi-La Cho; Pojen P Chen; Young-Il Seo; Sue-Yun Hwang; Wan-Uk Kim; Do-June Min; Sung-Hwan Park; Chul-Soo Cho
Association of homozygous deletion of the Humhv3005 and the VH3-30.3 genes with renal involvement in systemic lupus erythematosus.
Lupus 2003;12(5):400-5.
2002: Reginald U Chukwuocha; Min Zhu; Chul Soo Cho; Sudha Visvanathan; Kwan-Ki Hwang; Anisur Rahman; Pojen P Chen
Molecular and genetic characterizations of five pathogenic and two non-pathogenic monoclonal antiphospholipid antibodies.
Molecular immunology 2002;39(5-6):299-311.
2002: Chul-Soo Cho; Mi-La Cho; Pojen P Chen; So-Youn Min; Sue-Yun Hwang; Kyung-Soo Park; Wan-Uk Kim; Do-June Min; Jun-Ki Min; Sung-Hwan Park; Ho-Youn Kim
Antiphospholipid antibodies induce monocyte chemoattractant protein-1 in endothelial cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(8):4209-15.
2001: Kwan-Ki Hwang; Jennifer M Grossman; Sudha Visvanathan; Reginald U Chukwuocha; V L Woods; DT Le; Bevra H Hahn; Pojen P Chen
Identification of anti-thrombin antibodies in the antiphospholipid syndrome that interfere with the inactivation of thrombin by antithrombin.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(12):7192-8.
2001: Sohvi Hörkkö; T Olee; L Mo; D W Branch; VL Woods; Wulf Palinski; Pojen P Chen; Joseph L Witztum
Anticardiolipin antibodies from patients with the antiphospholipid antibody syndrome recognize epitopes in both beta(2)-glycoprotein 1 and oxidized low-density lipoprotein.
Circulation 2001;103(7):941-6.
2000: Silvia S Pierangeli; Xiaowei Liu; Ricardo G Espinola; T Olee; M Zhu; N E Harris; Pojen P Chen
Functional analyses of patient-derived IgG monoclonal anticardiolipin antibodies using in vivo thrombosis and in vivo microcirculation models.
Thrombosis and haemostasis 2000;84(3):388-95.
1999: Reginald U Chukwuocha; E T Hsiao; P Shaw; J L Witztum; Pojen P Chen
Isolation, characterization and sequence analysis of five IgG monoclonal anti-beta 2-glycoprotein-1 and anti-prothrombin antigen-binding fragments generated by phage display.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(8):4604-11.
1999: Y Zhao; Robert Rumold; M Zhu; D Zhou; Alaa Ahmed; DT Le; Bevra H Hahn; V L Woods; Pojen P Chen
An IgG antiprothrombin antibody enhances prothrombin binding to damaged endothelial cells and shortens plasma coagulation times.
Arthritis and rheumatism 1999;42(10):2132-8.
1999: Reginald U Chukwuocha; B Zhang; C J Lai; John Scavulli; Salvatore Albani; Dennis A Carson; Pojen P Chen
Isolation of an IgG monoclonal anti-dnaJ antibody from an immunoglobulin combinatorial library from a patient with rheumatoid arthritis.
The Journal of rheumatology 1999;26(7):1439-45.
1999: M Zhu; T Olee; DT Le; Robert A S Roubey; Bevra H Hahn; VL Woods; Pojen P Chen
Characterization of IgG monoclonal anti-cardiolipin/anti-beta2GP1 antibodies from two patients with antiphospholipid syndrome reveals three species of antibodies.
British journal of haematology 1999;105(1):102-9.
1999: Y Y Yang; P Fischer; S J Leu; M Zhu; V L Woods; Pojen P Chen
Possible presence of enhancing antibodies in idiopathic thrombocytopenic purpura.
British journal of haematology 1999;104(1):69-80.
1998: C J Lai; J Rauch; C S Cho; Y Zhao; Reginald U Chukwuocha; Pojen P Chen
Immunological and molecular analysis of three monoclonal lupus anticoagulant antibodies from a patient with systemic lupus erythematosus.
Journal of autoimmunity 1998;11(1):39-51.
1997: C S Cho; X Wang; Y Zhao; Dennis A Carson; Pojen P Chen
Genotyping by PCR-ELISA of a complex polymorphic region that contains one to four copies of six highly homologous human VH3 genes.
Proceedings of the Association of American Physicians 1997;109(6):558-64.
1997: Y Y Yang; P Fischer; S J Leu; T Olee; Dennis A Carson; Pojen P Chen
IgG rheumatoid factors isolated by the surface-displaying phage library technique.
Immunogenetics 1997;45(5):301-10.
1996: H Kohsaka; Dennis A Carson; Laura Rassenti; W E Ollier; Pojen P Chen; Thomas Kipps; N Miyasaka
The human immunoglobulin V(H) gene repertoire is genetically controlled and unaltered by chronic autoimmune stimulation.
The Journal of clinical investigation 1996;98(12):2794-800.
1996: T Olee; S S Pierangeli; H H Handley; D T Le; X Wei; C J Lai; J En; W Novotny; E N Harris; V L Woods; Pojen P Chen
A monoclonal IgG anticardiolipin antibody from a patient with the antiphospholipid syndrome is thrombogenic in mice.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8606-11.
1996: L Mo; S J Leu; C Berry; Fu-Tong Liu; T Olee; Y Y Yang; D S Beardsley; R McMillan; V L Woods; Pojen P Chen
The frequency of homozygous deletion of a developmentally regulated Vh gene (Humhv3005) is increased in patients with chronic idiopathic thrombocytopenic purpura.
Autoimmunity 1996;24(4):257-63.
1995: D F Huang; Katherine A Siminovitch; X Y Liu; T Olee; N J Olsen; C Berry; Dennis A Carson; Pojen P Chen
Population and family studies of three disease-related polymorphic genes in systemic lupus erythematosus.
The Journal of clinical investigation 1995;95(4):1766-72.
1994: M Deftos; T Olee; Dennis A Carson; Pojen P Chen
Defining the genetic origins of three rheumatoid synovium-derived IgG rheumatoid factors.
The Journal of clinical investigation 1994;93(6):2545-53.
1994: Richard W Ermel; Thomas P Kenny; A Wong; Alan Solomon; Pojen P Chen; Dick L Robbins
Preferential utilization of a novel V lambda 3 gene in monoclonal rheumatoid factors derived from the synovial cells of rheumatoid arthritis patients.
Arthritis and rheumatism 1994;37(6):860-8.
1994: P Fischer; S J Leu; Y Y Yang; Pojen P Chen
Rapid simultaneous screening for DNA integrity and antigen specificity of clones selected by phage display.
BioTechniques 1994;16(5):828-30.
1994: M Deftos; R Soto-Gil; M Quan; T Olee; Pojen P Chen
Utilization of a potentially universal downstream primer in the rapid identification and characterization of V lambda genes from two new human V lambda gene families.
Scandinavian journal of immunology 1994;39(1):95-103.
1993: H Kohsaka; A Taniguchi; Pojen P Chen; W E Ollier; Dennis A Carson
The expressed T cell receptor V gene repertoire of rheumatoid arthritis monozygotic twins: rapid analysis by anchored polymerase chain reaction and enzyme-linked immunosorbent assay.
European journal of immunology 1993;23(8):1895-901.
1993: M D Daley; V Misener; T Olee; Pojen P Chen; Katherine A Siminovitch
Genetic analysis of the variable region genes encoding a monospecific human natural anti-DNA antibody.
Clinical and experimental immunology 1993;93(1):11-8.
1993: E W Lu; M Deftos; T Olee; D F Huang; R W Soto-Gil; Dennis A Carson; Pojen P Chen
Generation and molecular analyses of two rheumatoid synovial fluid-derived IgG rheumatoid factors.
Arthritis and rheumatism 1993;36(7):927-37.
1993: P M Yang; T Olee; Dennis A Carson; Pojen P Chen
Characterization of two highly homologous autoantibody-related VH1 genes in humans.
Scandinavian journal of immunology 1993;37(4):504-8.
1993: Richard W Ermel; Thomas P Kenny; Pojen P Chen; Dick L Robbins
Molecular analysis of rheumatoid factors derived from rheumatoid synovium suggests an antigen-driven response in inflamed joints.
Arthritis and rheumatism 1993;36(3):380-8.
1993: H Kohsaka; Pojen P Chen; A Taniguchi; W E Ollier; Dennis A Carson
Divergent T cell receptor gamma repertoires in rheumatoid arthritis monozygotic twins.
Arthritis and rheumatism 1993;36(2):213-21.
1993: Helen Tighe; Pojen P Chen; R Tucker; Thomas Kipps; Jean Roudier; F R Jirik; Dennis A Carson
Function of B cells expressing a human immunoglobulin M rheumatoid factor autoantibody in transgenic mice.
The Journal of experimental medicine 1993;177(1):109-18.
1993: H Kohsaka; Pojen P Chen; A Taniguchi; W E Ollier; Dennis A Carson
Regulation of the mature human T cell receptor gamma repertoire by biased V-J gene rearrangement.
The Journal of clinical investigation 1993;91(1):171-8.
1992: M D Daley; H Q Peng; V Misener; X Y Liu; Pojen P Chen; Katherine A Siminovitch
Molecular analysis of human immunoglobulin V lambda germline genes: subgroups V lambda III and V lambda IV.
Molecular immunology 1992;29(12):1515-8.
1992: D F Huang; T Olee; Y Masuho; Y Matsumoto; Dennis A Carson; Pojen P Chen
Sequence analyses of three immunoglobulin G anti-virus antibodies reveal their utilization of autoantibody-related immunoglobulin Vh genes, but not V lambda genes.
The Journal of clinical investigation 1992;90(6):2197-208.
1992: M D Daley; T Olee; H Q Peng; R W Soto-Gil; Pojen P Chen; Katherine A Siminovitch
Molecular characterization of the human immunoglobulin V lambda I germline gene repertoire.
Molecular immunology 1992;29(9):1031-42.
1992: T Olee; E W Lu; D F Huang; R W Soto-Gil; M Deftos; F Kozin; Dennis A Carson; Pojen P Chen
Genetic analysis of self-associating immunoglobulin G rheumatoid factors from two rheumatoid synovia implicates an antigen-driven response.
The Journal of experimental medicine 1992;175(3):831-42.
1992: R W Soto-Gil; T Olee; B K Klink; Thomas P Kenny; Dick L Robbins; Dennis A Carson; Pojen P Chen
A systematic approach to defining the germline gene counterparts of a mutated autoantibody from a patient with rheumatoid arthritis.
Arthritis and rheumatism 1992;35(3):356-63.
1992: E W Lu; M Deftos; Helen Tighe; Dennis A Carson; Pojen P Chen
Generation and characterization of two monoclonal self-associating IgG rheumatoid factors from a rheumatoid synovium.
Arthritis and rheumatism 1992;35(1):101-5.
1991: P M Yang; J J Crowley; D O McDaniel; W J Koopman; F Kozin; Dennis A Carson; Pojen P Chen
Genetic studies of four highly homologous rheumatoid factor-associated Vk genes in rheumatoid arthritis patients and normal individuals.
Molecular immunology 1991;28(10):1073-83.
1991: Laura Rassenti; L F Pratt; Pojen P Chen; Dennis A Carson; Thomas Kipps
Autoantibody-encoding kappa L chain genes frequently rearranged in lambda L chain-expressing chronic lymphocytic leukemia.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(3):1060-6.
1991: T Olee; P M Yang; Katherine A Siminovitch; N J Olsen; J Hillson; J Wu; F Kozin; Dennis A Carson; Pojen P Chen
Molecular basis of an autoantibody-associated restriction fragment length polymorphism that confers susceptibility to autoimmune diseases.
The Journal of clinical investigation 1991;88(1):193-203.
1991: Dennis A Carson; Pojen P Chen; Thomas Kipps
New roles for rheumatoid factor.
The Journal of clinical investigation 1991;87(2):379-83.
1991: Dennis A Carson; Pojen P Chen; Gregg J Silverman; Thomas Kipps
Immunoglobulin gene expression in systemic rheumatic diseases.
British journal of rheumatology 1991;30 Suppl 1():43-6.
1990: P M Yang; N J Olsen; Katherine A Siminovitch; T Olee; F Kozin; Dennis A Carson; Pojen P Chen
Possible deletion of a developmentally regulated heavy-chain variable region gene in autoimmune diseases.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(20):7907-11.
1990: Dick L Robbins; Thomas P Kenny; M J Coloma; J V Gavilondo-Cowley; R W Soto-Gil; Pojen P Chen; J W Larrick
Serologic and molecular characterization of a human monoclonal rheumatoid factor derived from rheumatoid synovial cells.
Arthritis and rheumatism 1990;33(8):1188-95.
1990: Pojen P Chen; R W Soto-Gil; Dennis A Carson
The early expression of some human autoantibody-associated heavy chain variable region genes is controlled by specific regulatory elements.
Scandinavian journal of immunology 1990;31(6):673-8.
1990: Pojen P Chen; P M Yang
A segment of human Vh gene locus is duplicated.
Scandinavian journal of immunology 1990;31(5):593-9.
1990: Pojen P Chen
Structural analyses of human developmentally regulated Vh3 genes.
Scandinavian journal of immunology 1990;31(3):257-67.
1990: Jean Roudier; Gregg J Silverman; Pojen P Chen; Dennis A Carson; Thomas Kipps
Intraclonal diversity in the VH genes expressed by CD5- chronic lymphocytic leukemia-producing pathologic IgM rheumatoid factor.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(4):1526-30.
1990: Katherine A Siminovitch; Pojen P Chen
The biologic significance of human natural autoimmune responses: relationship to the germline, early immune and malignant B cell variable gene repertoire.
International reviews of immunology 1990;5(3-4):265-77.
1990: Pojen P Chen; N J Olsen; P M Yang; R W Soto-Gil; T Olee; Katherine A Siminovitch; Dennis A Carson
From human autoantibodies to the fetal antibody repertoire to B cell malignancy: it's a small world after all.
International reviews of immunology 1990;5(3-4):239-51.
1990: Katherine A Siminovitch; V Misener; P C Kwong; P M Yang; Carl A Laskin; E Cairns; D Bell; L A Rubin; Pojen P Chen
A human anti-cardiolipin autoantibody is encoded by developementally restricted heavy and light chain variable region genes.
Autoimmunity 1990;8(2):97-105.
1990: J J Crowley; R A Mageed; Gregg J Silverman; Pojen P Chen; F Kozin; R A Erger; R Jefferis; Dennis A Carson
The incidence of a new human cross-reactive idiotype linked to subgroup VHIII heavy chains.
Molecular immunology 1990;27(1):87-94.
1989: Katherine A Siminovitch; V Misener; P C Kwong; Q L Song; Pojen P Chen
A natural autoantibody is encoded by germline heavy and lambda light chain variable region genes without somatic mutation.
The Journal of clinical investigation 1989;84(5):1675-8.
1989: Dennis A Carson; Pojen P Chen; Thomas Kipps; Jean Roudier; Gregg J Silverman; Helen Tighe
Regulation of rheumatoid factor synthesis.
Clinical and experimental rheumatology 1989;7 Suppl 3():S69-73.
1989: Pojen P Chen; Katherine A Siminovitch; N J Olsen; R A Erger; Dennis A Carson
A highly informative probe for two polymorphic Vh gene regions that contain one or more autoantibody-associated Vh genes.
The Journal of clinical investigation 1989;84(2):706-10.
1989: Thomas Kipps; E Tomhave; L F Pratt; S Duffy; Pojen P Chen; Dennis A Carson
Developmentally restricted immunoglobulin heavy chain variable region gene expressed at high frequency in chronic lymphocytic leukemia.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(15):5913-7.
1989: Thomas Kipps; E Tomhave; Pojen P Chen; R I Fox
Molecular characterization of a major autoantibody-associated cross-reactive idiotype in Sjogren's syndrome.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(12):4261-8.
1989: M F Liu; D L Robbins; J J Crowley; S Sinha; F Kozin; Thomas Kipps; Dennis A Carson; Pojen P Chen
Characterization of four homologous L chain variable region genes that are related to 6B6.6 idiotype positive human rheumatoid factor L chains.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(2):688-94.
1988: Thomas Kipps; E Tomhave; Pojen P Chen; Dennis A Carson
Autoantibody-associated kappa light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation. Implications for etiology and immunotherapy.
The Journal of experimental medicine 1988;167(3):840-52.
1988: S Fong; Pojen P Chen; R I Fox; R D Goldfien; V Radoux; Gregg J Silverman; J J Crowley; Jean Roudier; Dennis A Carson
The diversity and idiotypic patterns of human rheumatoid factors in disease.
Concepts in immunopathology 1988;5():168-91.
1987: Dennis A Carson; Pojen P Chen; Thomas Kipps; V Radoux; F R Jirik; R D Goldfien; R I Fox; Gregg J Silverman; S Fong
Idiotypic and genetic studies of human rheumatoid factors.
Arthritis and rheumatism 1987;30(12):1321-5.
1987: Pojen P Chen; K Albrandt; Thomas Kipps; V Radoux; Fu-Tong Liu; Dennis A Carson
Isolation and characterization of human VkIII germ-line genes. Implications for the molecular basis of human VkIII light chain diversity.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(5):1727-33.
1987: Pojen P Chen; S Fong; Dennis A Carson
The use of defined peptides in characterizing idiotypes.
International reviews of immunology 1987;2(4):419-32.
1987: Thomas Kipps; S Fong; E Tomhave; Pojen P Chen; R D Goldfien; Dennis A Carson
High-frequency expression of a conserved kappa light-chain variable-region gene in chronic lymphocytic leukemia.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(9):2916-20.
1987: Pojen P Chen; S Fong; F Goni; R A Houghten; Blas Frangione; Fu-Tong Liu; Dennis A Carson
Analyses of human rheumatoid factors with anti-idiotypes induced by synthetic peptides.
Monographs in allergy 1987;22():12-23.
1987: Dennis A Carson; Pojen P Chen; Thomas Kipps; V Radoux; F Jirik; R D Goldfien; R I Fox; Gregg J Silverman; S Fong
Molecular basis for the cross-reactive idiotypes on human anti-IgG autoantibodies (rheumatoid factors).
Ciba Foundation symposium 1987;129():123-34.
1987: Dennis A Carson; Pojen P Chen; R I Fox; Thomas Kipps; F Jirik; R D Goldfien; G Silverman; V Radoux; S Fong
Rheumatoid factor and immune networks.
Annual review of immunology 1987;5():109-26.
1986: Pojen P Chen; K Albrandt; N K Orida; V Radoux; E Y Chen; R Schrantz; Fu-Tong Liu; Dennis A Carson
Genetic basis for the cross-reactive idiotypes on the light chains of human IgM anti-IgG autoantibodies.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(21):8318-22.
1986: F R Jirik; J Sorge; S Fong; J G Heitzmann; J G Curd; Pojen P Chen; R Goldfien; Dennis A Carson
Cloning and sequence determination of a human rheumatoid factor light-chain gene.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(7):2195-9.
1986: S Fong; Pojen P Chen; R I Fox; R D Goldfien; Gregg J Silverman; V Radoux; F Jirik; J H Vaughan; Dennis A Carson
Rheumatoid factors in human autoimmune disease: their origin, development and function.
Pathology and immunopathology research 1986;5(3-5):305-16.