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Shiuan Chen

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Fengjuan Li; Franky L Chan; Shiuan Chen; Wing-Hoi Cheung; Simon Chow; Lai K Leung
The citrus flavonone hesperetin prevents letrozole-induced bone loss in a mouse model of breast cancer.
Cristina Amaral; Margarida Azevedo; Shiuan Chen; Georgina Correia-da-Silva; Elisiário Tavares da Silva; Fernanda M F Roleira; Carla Varela; Natércia A A Teixeira
Effects of steroidal aromatase inhibitors on sensitive and resistant breast cancer cells: aromatase inhibition and autophagy.
Makoto Kubo; Zheng Liu; Reiki Nishimura; Masayuki Okido; Tomofumi Osako; Karineh Petrossian; Kazuo Shimada; Masato Takahashi; Charles Warden; Jingjing Ye; Yate-Ching Yuan; Peiguo Chu; Noriko Kanaya; Shiuan Chen
Inhibition of the proliferation of acquired aromatase inhibitor-resistant breast cancer cells by histone deacetylase inhibitor LBH589 (panobinostat).

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All Publications

2013: Fengjuan Li; Franky L Chan; Shiuan Chen; Wing-Hoi Cheung; Simon Chow; Lai K Leung
The citrus flavonone hesperetin prevents letrozole-induced bone loss in a mouse model of breast cancer.
The Journal of nutritional biochemistry 2013;24(6):1112-6.
2013: Cristina Amaral; Margarida Azevedo; Shiuan Chen; Georgina Correia-da-Silva; Elisiário Tavares da Silva; Fernanda M F Roleira; Carla Varela; Natércia A A Teixeira
Effects of steroidal aromatase inhibitors on sensitive and resistant breast cancer cells: aromatase inhibition and autophagy.
The Journal of steroid biochemistry and molecular biology 2013;135():51-9.
2013: Makoto Kubo; Zheng Liu; Reiki Nishimura; Masayuki Okido; Tomofumi Osako; Karineh Petrossian; Kazuo Shimada; Masato Takahashi; Charles Warden; Jingjing Ye; Yate-Ching Yuan; Peiguo Chu; Noriko Kanaya; Shiuan Chen
Inhibition of the proliferation of acquired aromatase inhibitor-resistant breast cancer cells by histone deacetylase inhibitor LBH589 (panobinostat).
Breast cancer research and treatment 2013;137(1):93-107.
2012: Lan Ye; Franky L Chan; Shiuan Chen; Lai K Leung
The citrus flavonone hesperetin inhibits growth of aromatase-expressing MCF-7 tumor in ovariectomized athymic mice.
The Journal of nutritional biochemistry 2012;23(10):1230-7.
2012: Cynthie Wong; Shiuan Chen
The development, application and limitations of breast cancer cell lines to study tamoxifen and aromatase inhibitor resistance.
The Journal of steroid biochemistry and molecular biology 2012;131(3-5):83-92.
2012: Cynthie Wong; Kaladhar B Reddy; David Smith; Xin Wang; Shiuan Chen
AKT-aro and HER2-aro, models for de novo resistance to aromatase inhibitors; molecular characterization and inhibitor response studies.
Breast cancer research and treatment 2012;134(2):671-81.
2012: Akihiro Tsuyada; Yuan-Zhong Wang; Jun Wu; Xiwei Wu; Wei Ye; Yang Yu; Weiying Zhou; Shiuan Chen; Amy Chow; Peiguo Chu; Yukio Kuroki; Arthur Xuejun Li; Hui Li; Sofia Loera; Thehang Luu; Xiubao Ren; Peggy Scherle; George Somlo; Shizhen Emily Wang
CCL2 mediates cross-talk between cancer cells and stromal fibroblasts that regulates breast cancer stem cells.
Cancer research 2012;72(11):2768-79.
2011: Lynn S Adams; Noriko Kanaya; Zheng Liu; Sheryl Phung; Shiuan Chen
Whole blueberry powder modulates the growth and metastasis of MDA-MB-231 triple negative breast tumors in nude mice.
The Journal of nutrition 2011;141(10):1805-12.
2011: Ayano Matsumoto-Takasaki; Hiroshi Nakada; Munehiro Nakata; Sheryl Phung; Keiko Sakai; Noriyuki Yuasa; Normaiza Zamri; Shiuan Chen; Daiichi Katagiri; Tsubasa Koyama; Yoko Fujita-Yamaguchi
Characterization of three different single chain antibodies recognizing non-reducing terminal mannose residues expressed in Escherichia coli by an inducible T7 expression system.
Journal of biochemistry 2011;150(4):439-50.
2011: Bo Zhong; Aimin Zhou; Xiaohan Cai; Shiuan Chen; Xin Yi; Bin Su
In vitro and in vivo effects of a cyclooxygenase-2 inhibitor nimesulide analog JCC76 in aromatase inhibitors-insensitive breast cancer cells.
The Journal of steroid biochemistry and molecular biology 2011;126(1-2):10-8.
2011: Yanyan Hong; Shiuan Chen
Aromatase, estrone sulfatase, and 17β-hydroxysteroid dehydrogenase: structure-function studies and inhibitor development.
Molecular and cellular endocrinology 2011;340(2):120-6.
2011: Yanyan Hong; Rumana Rashid; Shiuan Chen
Binding features of steroidal and nonsteroidal inhibitors.
Steroids 2011;76(8):802-6.
2011: Shiuan Chen
An "omics" approach to determine the mechanisms of acquired aromatase inhibitor resistance.
Omics : a journal of integrative biology 2011;15(6):347-52.
2011: Jürgen Geisler; Hironobu Sasano; Shiuan Chen; Atul Purohit
Steroid sulfatase inhibitors: promising new tools for breast cancer therapy?
The Journal of steroid biochemistry and molecular biology 2011;125(1-2):39-45.
2011: Bin Su; Cynthie Wong; Yanyan Hong; Shiuan Chen
Growth factor signaling enhances aromatase activity of breast cancer cells via post-transcriptional mechanisms.
The Journal of steroid biochemistry and molecular biology 2011;123(3-5):101-8.
2011: Keqiang Zhang; Jianming Lu; Taisuke Mori; Leslie Smith-Powell; Timothy W Synold; Shiuan Chen; Wei Wen
Baicalin increases VEGF expression and angiogenesis by activating the ERR{alpha}/PGC-1{alpha} pathway.
Cardiovascular research 2011;89(2):426-35.
2011: Yuanzhong Wang; Dujin Zhou; Sheryl Phung; Selma Masri; David Smith; Shiuan Chen
SGK3 is an estrogen-inducible kinase promoting estrogen-mediated survival of breast cancer cells.
Molecular endocrinology (Baltimore, Md.) 2011;25(1):72-82.
2011: Yuanzhong Wang; Bin Chen; Yuping Li; Dujin Zhou; Shiuan Chen
PNRC accumulates in the nucleolus by interaction with B23/nucleophosmin via its nucleolar localization sequence.
Biochimica et biophysica acta 2011;1813(1):109-19.
2010: Selma Masri; Zheng Liu; Sheryl Phung; Emily Wang; Yate-Ching Yuan; Shiuan Chen
The role of microRNA-128a in regulating TGFbeta signaling in letrozole-resistant breast cancer cells.
Breast cancer research and treatment 2010;124(1):89-99.
2010: Noriko Kanaya; Shiuan Chen
Conjugated linoleic acid reduces body weight gain in ovariectomized female C57BL/6J mice.
Nutrition research (New York, N.Y.) 2010;30(10):714-21.
2010: Bin Su; Xiaohan Cai; Yanyan Hong; Shiuan Chen
COX-2 inhibitor nimesulide analogs are aromatase suppressors in breast cancer cells.
The Journal of steroid biochemistry and molecular biology 2010;122(4):232-8.
2010: Martin Smollich; Martin Götte; Jeanett Fischgräbe; Luciana F Macedo; Angela Brodie; Shiuan Chen; Isabel Radke; Ludwig Kiesel; Pia Wülfing
ETAR antagonist ZD4054 exhibits additive effects with aromatase inhibitors and fulvestrant in breast cancer therapy, and improves in vivo efficacy of anastrozole.
Breast cancer research and treatment 2010;123(2):345-57.
2010: Shiuan Chen; Jingjing Ye; Ikuko Kijima; Dean Evans
The HDAC inhibitor LBH589 (panobinostat) is an inhibitory modulator of aromatase gene expression.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(24):11032-7.
2010: Lynn S Adams; Sheryl Phung; Natalie Yee; Navindra P Seeram; Liya Li; Shiuan Chen
Blueberry phytochemicals inhibit growth and metastatic potential of MDA-MB-231 breast cancer cells through modulation of the phosphatidylinositol 3-kinase pathway.
Cancer research 2010;70(9):3594-605.
2010: Yanyan Hong; Hongzhi Li; Yate-Ching Yuan; Shiuan Chen
Sequence-function correlation of aromatase and its interaction with reductase.
The Journal of steroid biochemistry and molecular biology 2010;118(4-5):203-6.
2010: Selma Masri; Sheryl Phung; Xin Wang; Shiuan Chen
Molecular characterization of aromatase inhibitor-resistant, tamoxifen-resistant and LTEDaro cell lines.
The Journal of steroid biochemistry and molecular biology 2010;118(4-5):277-82.
2010: Ratna K Vadlamudi; Rajib Rajhans; Dimple Chakravarty; Binoj C Nair; Sujit S Nair; Dean B Evans; Shiuan Chen; Rajeshwar Tekmal
Regulation of aromatase induction by nuclear receptor coregulator PELP1.
The Journal of steroid biochemistry and molecular biology 2010;118(4-5):211-8.
2010: Lynn S Adams; Yanjun Zhang; Navindra P Seeram; David Heber; Shiuan Chen
Pomegranate ellagitannin-derived compounds exhibit antiproliferative and antiaromatase activity in breast cancer cells in vitro.
Cancer prevention research (Philadelphia, Pa.) 2010;3(1):108-13.
2009: Bin Su; Shiuan Chen
Lead optimization of COX-2 inhibitor nimesulide analogs to overcome aromatase inhibitor resistance in breast cancer cells.
Bioorganic & medicinal chemistry letters 2009;19(23):6733-5.
2009: Cynthie Wong; Shiuan Chen
Heat shock protein 90 inhibitors: new mode of therapy to overcome endocrine resistance.
Cancer research 2009;69(22):8670-7.
2009: Selma Masri; Ki Lui; Sheryl Phung; Jingjing Ye; Dujin Zhou; Xin Wang; Shiuan Chen
Characterization of the weak estrogen receptor alpha agonistic activity of exemestane.
Breast cancer research and treatment 2009;116(3):461-70.
2009: Bin Chen; Bin Su; Shiuan Chen
A COX-2 inhibitor nimesulide analog selectively induces apoptosis in Her2 overexpressing breast cancer cells via cytochrome c dependent mechanisms.
Biochemical pharmacology 2009;77(12):1787-94.
2009: Jianming Lu; Keqiang Zhang; Shiuan Chen; Wei Wen
Grape seed extract inhibits VEGF expression via reducing HIF-1alpha protein expression.
Carcinogenesis 2009;30(4):636-44.
2009: Liya Li; Lynn S Adams; Shiuan Chen; Caroline Killian; Aftab Ahmed; Navindra P Seeram
Eugenia jambolana Lam. berry extract inhibits growth and induces apoptosis of human breast cancer but not non-tumorigenic breast cells.
Journal of agricultural and food chemistry 2009;57(3):826-31.
2009: Yanyan Hong; Hongzhi Li; Yate-Ching Yuan; Shiuan Chen
Molecular characterization of aromatase.
Annals of the New York Academy of Sciences 2009;1155():112-20.
2009: Yanyan Hong; Hongzhi Li; Jingjing Ye; Yasuhiro Miki; Yate-Ching Yuan; Hironobu Sasano; Dean B Evans; Shiuan Chen
Epitope characterization of an aromatase monoclonal antibody suitable for the assessment of intratumoral aromatase activity.
PloS one 2009;4(11):e8050.
2009: Lynn S Adams; Shiuan Chen
Phytochemicals for breast cancer prevention by targeting aromatase.
Frontiers in bioscience : a journal and virtual library 2009;14():3846-63.
2008: Wei Wen; Jianming Lu; Keqiang Zhang; Shiuan Chen
Grape seed extract inhibits angiogenesis via suppression of the vascular endothelial growth factor receptor signaling pathway.
Cancer prevention research (Philadelphia, Pa.) 2008;1(7):554-61.
2008: Bin Chen; Yuanzhong Wang; Susan E Kane; Shiuan Chen
Improvement of sensitivity to tamoxifen in estrogen receptor-positive and Herceptin-resistant breast cancer cells.
Journal of molecular endocrinology 2008;41(5):367-77.
2008: Yuanzhong Wang; Yuping Li; Bin Chen; Yan Zhang; Guiyu Lou; Shiuan Chen; Dujin Zhou
Identification and characterization of PNRC splicing variants.
Gene 2008;423(2):116-24.
2008: Paul A Foster; Surinder K Chander; Simon P Newman; L W Lawrence Woo; Oliver B Sutcliffe; Christian Bubert; Dujin Zhou; Shiuan Chen; Barry V L Potter; Michael J Reed; Atul Purohit
A new therapeutic strategy against hormone-dependent breast cancer: the preclinical development of a dual aromatase and sulfatase inhibitor.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(20):6469-77.
2008: cepa margarida; Georgina Correia-da-Silva; Elisiário J Tavares da Silva; Fernanda M F Roleira; Yanyan Hong; Shiuan Chen; Natércia A Teixeira
Molecular mechanisms of aromatase inhibition by new A, D-ring modified steroids.
Biological chemistry 2008;389(9):1183-91.
2008: Ki Lui; Takaya Tamura; Taisuke Mori; Dujin Zhou; Shiuan Chen
MCF-7aro/ERE, a novel cell line for rapid screening of aromatase inhibitors, ERalpha ligands and ERRalpha ligands.
Biochemical pharmacology 2008;76(2):208-15.
2008: Selma Masri; Sheryl Phung; Xin Wang; Xiwei Wu; Yate-Ching Yuan; Lawrence D Wagman; Shiuan Chen
Genome-wide analysis of aromatase inhibitor-resistant, tamoxifen-resistant, and long-term estrogen-deprived cells reveals a role for estrogen receptor.
Cancer research 2008;68(12):4910-8.
2008: Ikuko Kijima; Jingjing Ye; Carlotta Glackin; Shiuan Chen
CCAAT/enhancer binding protein delta up-regulates aromatase promoters I.3/II in breast cancer epithelial cells.
Cancer research 2008;68(11):4455-64.
2008: S Yu; Yong-Chuan Wong; X H Wang; M T Ling; Chi-Fai Ng; Shiuan Chen; Franky Chan
Orphan nuclear receptor estrogen-related receptor-beta suppresses in vitro and in vivo growth of prostate cancer cells via p21(WAF1/CIP1) induction and as a potential therapeutic target in prostate cancer.
Oncogene 2008;27(23):3313-28.
2008: Yuping Li; Bin Chen; Jian Chen; Guiyu Lou; Shiuan Chen; Dujin Zhou
Fast skeletal muscle troponin I is a co-activator of estrogen receptor-related receptor alpha.
Biochemical and biophysical research communications 2008;369(4):1034-40.
2008: Xin Wang; Selma Masri; Sheryl Phung; Shiuan Chen
The role of amphiregulin in exemestane-resistant breast cancer cells: evidence of an autocrine loop.
Cancer research 2008;68(7):2259-65.
2008: Yanyan Hong; Michael Cho; Yate-Ching Yuan; Shiuan Chen
Molecular basis for the interaction of four different classes of substrates and inhibitors with human aromatase.
Biochemical pharmacology 2008;75(5):1161-9.
2008: Rajib Rajhans; Hareesh B. Nair; Sujit S Nair; Valerie Cortez; Kijima Ikuko; Nameer Kirma; Dujin Zhou; Alan EC Holden; Darrell W Brann; Shiuan Chen; Rajeshwar Tekmal; Ratna K Vadlamudi
Modulation of in situ estrogen synthesis by proline-, glutamic acid-, and leucine-rich protein-1: potential estrogen receptor autocrine signaling loop in breast cancer cells.
Molecular endocrinology (Baltimore, Md.) 2008;22(3):649-64.
2008: Ben Chung-Lap Chan; Arthur Kar-Keung Ching; Ka-Fai To; J C-K Leung; Shiuan Chen; Qing Li; P B-S Lai; Nelson Tang; P-C Shaw; J Y-H Chan; Anthony Edward James; K-N Lai; Pak-Leong Lim; K K-H Lee; Yiu Loon Chui
BRE is an antiapoptotic protein in vivo and overexpressed in human hepatocellular carcinoma.
Oncogene 2008;27(9):1208-17.
2008: Yun Wang; Wai Man Gho; Franky Chan; Shiuan Chen; Lai K Leung
The red clover (Trifolium pratense) isoflavone biochanin A inhibits aromatase activity and expression.
The British journal of nutrition 2008;99(2):303-10.
2008: Dujin Zhou; Ruoqing Shen; Jing Jing Ye; Yuping Li; Walter Tsark; Donna Isbell; Patrick Tso; Shiuan Chen
Nuclear receptor coactivator PNRC2 regulates energy expenditure and adiposity.
The Journal of biological chemistry 2008;283(1):541-53.
2008: Joanna Lisztwan; Astrid Pornon; Bin Chen; Shiuan Chen; Dean B Evans
The aromatase inhibitor letrozole and inhibitors of insulin-like growth factor I receptor synergistically induce apoptosis in in vitro models of estrogen-dependent breast cancer.
Breast cancer research : BCR 2008;10(4):R56.
2007: Shiuan Chen; Selma Masri; Yanyan Hong; Xin Wang; Sheryl Phung; Yate-Ching Yuan; Xiwei Wu
New experimental models for aromatase inhibitor resistance.
The Journal of steroid biochemistry and molecular biology 2007;106(1-5):8-15.
2007: Shan Yu; Xianghong Wang; Chi-Fai Ng; Shiuan Chen; Franky Chan
ERRgamma suppresses cell proliferation and tumor growth of androgen-sensitive and androgen-insensitive prostate cancer cells and its implication as a therapeutic target for prostate cancer.
Cancer research 2007;67(10):4904-14.
2007: Yanyan Hong; Bin Yu; Mark Sherman; Yate-Ching Yuan; Dujin Zhou; Shiuan Chen
Molecular basis for the aromatization reaction and exemestane-mediated irreversible inhibition of human aromatase.
Molecular endocrinology (Baltimore, Md.) 2007;21(2):401-14.
2007: Dujin Zhou; Shuping Zhong; Jing-Jing Ye; Keith M Quach; Deborah L Johnson; Shiuan Chen
PNRC is a unique nuclear receptor coactivator that stimulates RNA polymerase III-dependent transcription.
Journal of molecular signaling 2007;2():5.
2006: Shiuan Chen; Sei-Ryang Oh; Sheryl Phung; Gene Hur; Jing Jing Ye; Sum Ling Kwok; Gayle E Shrode; Martha A Belury; Lynn S Adams; Dudley Williams
Anti-aromatase activity of phytochemicals in white button mushrooms (Agaricus bisporus).
Cancer research 2006;66(24):12026-34.
2006: Shiuan Chen; Selma Masri; Xin Wang; Sheryl Phung; Yate-Ching Yuan; Xiwei Wu
What do we know about the mechanisms of aromatase inhibitor resistance?
The Journal of steroid biochemistry and molecular biology 2006;102(1-5):232-40.
2006: Yanyan Hong; Shiuan Chen
Aromatase inhibitors: structural features and biochemical characterization.
Annals of the New York Academy of Sciences 2006;1089():237-51.
2006: Xin Wang; Shiuan Chen
Aromatase destabilizer: novel action of exemestane, a food and drug administration-approved aromatase inhibitor.
Cancer research 2006;66(21):10281-6.
2006: Ki Lui; Yu Huang; HL Choi; Shan Yu; K B Wong; Shiuan Chen; Franky Chan
Molecular cloning and functional study of rat estrogen receptor-related receptor gamma in rat prostatic cells.
The Prostate 2006;66(15):1600-19.
2006: Yun Wang; Kai Woo Lee; Franky Chan; Shiuan Chen; Lai K Leung
The red wine polyphenol resveratrol displays bilevel inhibition on aromatase in breast cancer cells.
Toxicological sciences : an official journal of the Society of Toxicology 2006;92(1):71-7.
2006: Ikuko Kijima; Sheryl Phung; Gene Hur; Sum-Ling Kwok; Shiuan Chen
Grape seed extract is an aromatase inhibitor and a suppressor of aromatase expression.
Cancer research 2006;66(11):5960-7.
2006: Dujin Zhou; Jing Jing Ye; Yuping Li; Ki Lui; Shiuan Chen
The molecular basis of the interaction between the proline-rich SH3-binding motif of PNRC and estrogen receptor alpha.
Nucleic acids research 2006;34(20):5974-86.
2005: Ikuko Kijima; Toru Itoh; Shiuan Chen
Growth inhibition of estrogen receptor-positive and aromatase-positive human breast cancer cells in monolayer and spheroid cultures by letrozole, anastrozole, and tamoxifen.
The Journal of steroid biochemistry and molecular biology 2005;97(4):360-8.
2005: Dujin Zhou; Selma Masri; Jing Jing Ye; Shiuan Chen
Transcriptional regulation of the mouse PNRC2 promoter by the nuclear factor Y (NFY) and E2F1.
Gene 2005;361():89-100.
2005: Anne Boulay; Joelle Rudloff; Jingjing Ye; Sabine Zumstein-Mecker; Terence O'Reilly; Dean B Evans; Shiuan Chen; Heidi A Lane
Dual inhibition of mTOR and estrogen receptor signaling in vitro induces cell death in models of breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(14):5319-28.
2005: Yun Wang; Franky Chan; Shiuan Chen; Lai K Leung
The plant polyphenol butein inhibits testosterone-induced proliferation in breast cancer cells expressing aromatase.
Life sciences 2005;77(1):39-51.
2005: Shiuan Chen; Jingjing Ye; Ikuko Kijima; Yoshiyuki Kinoshita; Dujin Zhou
Positive and negative transcriptional regulation of aromatase expression in human breast cancer tissue.
The Journal of steroid biochemistry and molecular biology 2005;95(1-5):17-23.
2005: Zhibo Yang; Rayala Suresh; Diep Nguyen; Ratna K Vadlamudi; Shiuan Chen; Rakesh Kumar
Pak1 phosphorylation of snail, a master regulator of epithelial-to-mesenchyme transition, modulates snail's subcellular localization and functions.
Cancer research 2005;65(8):3179-84.
2005: Toru Itoh; Kimberly Karlsberg; Ikuko Kijima; Yate-Ching Yuan; David Smith; Jingjing Ye; Shiuan Chen
Letrozole-, anastrozole-, and tamoxifen-responsive genes in MCF-7aro cells: a microarray approach.
Molecular cancer research : MCR 2005;3(4):203-18.
2005: C P Cheung; Shan Yu; K B Wong; L W Chan; Fernand Mac-Moune Lai; Xianghong Wang; Masatomo Suetsugi; Shiuan Chen; Franky Chan
Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues.
The Journal of clinical endocrinology and metabolism 2005;90(3):1830-44.
2004: Shiuan Chen; Michael Cho; Kimberly Karlsberg; Dujin Zhou; Yate-Ching Yuan
Biochemical and biological characterization of a novel anti-aromatase coumarin derivative.
The Journal of biological chemistry 2004;279(46):48071-8.
2004: Dujin Zhou; Bin Chen; Jing-Jing Ye; Shiuan Chen
A novel crosstalk mechanism between nuclear receptor-mediated and growth factor/Ras-mediated pathways through PNRC-Grb2 interaction.
Oncogene 2004;23(31):5394-404.
2004: Richard J Knox; Shiuan Chen
Quinone reductase-mediated nitro-reduction: clinical applications.
Methods in enzymology 2004;382():194-221.
2003: Elizabeth T Eng; JingJing Ye; Dudley Williams; Sheryl Phung; Roger Moore; Mary K Young; Ugis Gruntmanis; Glenn D Braunstein; Shiuan Chen
Suppression of estrogen biosynthesis by procyanidin dimers in red wine and grape seeds.
Cancer research 2003;63(23):8516-22.
2003: Masatomo Suetsugi; Leila Su; Kimberly Karlsberg; Yate-Ching Yuan; Shiuan Chen
Flavone and isoflavone phytoestrogens are agonists of estrogen-related receptors.
Molecular cancer research : MCR 2003;1(13):981-91.
2003: Shiuan Chen; Fangming Zhang; Mark A Sherman; Ikuko Kijima; Michael Cho; Yate-Ching Yuan; Yoshiro Toma; Yoshio Osawa; Dujin Zhou; Elizabeth T Eng
Structure-function studies of aromatase and its inhibitors: a progress report.
The Journal of steroid biochemistry and molecular biology 2003;86(3-5):231-7.
2003: Luigi Castagnetta; Biagio Agostara; Giuseppe Montalto; Lucia Polito; Ildegarda Campisi; Annalisa Saetta; Toru Itoh; Bin Yu; Shiuan Chen; Giuseppe Carruba
Local estrogen formation by nontumoral, cirrhotic, and malignant human liver tissues and cells.
Cancer research 2003;63(16):5041-5.
2003: Yoshiyuki Kinoshita; Shiuan Chen
Induction of aromatase (CYP19) expression in breast cancer cells through a nongenomic action of estrogen receptor alpha.
Cancer research 2003;63(13):3546-55.
2003: Shu-Yan Cheung; Mong-Ting Yuen; HL Choi; H K Cheng; Yu Huang; Shiuan Chen; Franky Chan
An expression study of hormone receptors in spontaneously developed, carcinogen-induced and hormone-induced mammary tumors in female Noble rats.
International journal of oncology 2003;22(6):1383-95.
2003: Richard J Knox; Philip J Burke; Shiuan Chen; David J Kerr
CB 1954: from the Walker tumor to NQO2 and VDEPT.
Current pharmaceutical design 2003;9(26):2091-104.
2002: Shiuan Chen; Toru Itoh; Kebin Wu; Dujin Zhou; Chun Yang
Transcriptional regulation of aromatase expression in human breast tissue.
The Journal of steroid biochemistry and molecular biology 2002;83(1-5):93-9.
2002: Fangming Zhang; Dujin Zhou; Yeh-Chih Kao; Jingjing Ye; Shiuan Chen
Expression and purification of a recombinant form of human aromatase from Escherichia coli.
Biochemical pharmacology 2002;64(9):1317-24.
2002: Shiuan Chen
Modulation of aromatase activity and expression by environmental chemicals.
Frontiers in bioscience : a journal and virtual library 2002;7():d1712-9.
2002: Elizabeth T Eng; Dudley Williams; Usha Mandava; Nameer Kirma; Rajeshwar Tekmal; Shiuan Chen
Anti-aromatase chemicals in red wine.
Annals of the New York Academy of Sciences 2002;963():239-46.
2002: Shiuan Chen; Dujin Zhou; Tomoharu Okubo; Yeh-Chih Kao; Elizabeth T Eng; Baiba Grube; Annette Kwon; Chun Yang; Bin Yu
Prevention and treatment of breast cancer by suppressing aromatase activity and expression.
Annals of the New York Academy of Sciences 2002;963():229-38.
2002: Chun Yang; Bin Yu; Dujin Zhou; Shiuan Chen
Regulation of aromatase promoter activity in human breast tissue by nuclear receptors.
Oncogene 2002;21(18):2854-63.
2001: Shiuan Chen; Dujin Zhou; Chun Yang; Tomoharu Okubo; Yoshiyuki Kinoshita; Bin Yu; Yeh-Chih Kao; Toru Itoh
Modulation of aromatase expression in human breast tissue.
The Journal of steroid biochemistry and molecular biology 2001;79(1-5):35-40.
2001: Baiba Grube; Elizabeth T Eng; Yeh-Chih Kao; A Kwon; Shiuan Chen
White button mushroom phytochemicals inhibit aromatase activity and breast cancer cell proliferation.
The Journal of nutrition 2001;131(12):3288-93.
2001: Dujin Zhou; Shiuan Chen
PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif.
Nucleic acids research 2001;29(19):3939-48.
2001: J Zhao; P Mak; A Tchoudakova; Gloria V Callard; Shiuan Chen
Different catalytic properties and inhibitor responses of the goldfish brain and ovary aromatase isozymes.
General and comparative endocrinology 2001;123(2):180-91.
2001: Shiuan Chen; Dujin Zhou; Chun Yang; Mark Sherman
Molecular basis for the constitutive activity of estrogen-related receptor alpha-1.
The Journal of biological chemistry 2001;276(30):28465-70.
2001: Elizabeth T Eng; Dudley Williams; Usha Mandava; Nameer Kirma; Rajeshwar Tekmal; Shiuan Chen
Suppression of aromatase (estrogen synthetase) by red wine phytochemicals.
Breast cancer research and treatment 2001;67(2):133-46.
2001: Tomoharu Okubo; T K Truong; Bin Yu; Toru Itoh; J Zhao; Baiba Grube; Dujin Zhou; Shiuan Chen
Down-regulation of promoter 1.3 activity of the human aromatase gene in breast tissue by zinc-finger protein, snail (SnaH).
Cancer research 2001;61(4):1338-46.
2001: K Wu; E Eng; R Knox; Shiuan Chen
Demonstration of the activation of prodrug CB 1954 using human DT-diaphorase mutant Q104Y-transfected MDA-MB-231 cells and mouse xenograft model.
Archives of biochemistry and biophysics 2001;385(1):203-8.
2001: Dudley Williams; Shiuan Chen; Mary K Young
Ratiometric analysis of the ferrocene boronate esters of 2- and 4-hydroxyestradiol by tandem electrospray mass spectrometry.
Rapid communications in mass spectrometry : RCM 2001;15(3):182-6.
2001: Yeh-Chih Kao; K R Korzekwa; CA Laughton; Shiuan Chen
Evaluation of the mechanism of aromatase cytochrome P450. A site-directed mutagenesis study.
European journal of biochemistry / FEBS 2001;268(2):243-51.
2000: Tomoharu Okubo; S C Mok; Shiuan Chen
Regulation of aromatase expression in human ovarian surface epithelial cells.
The Journal of clinical endocrinology and metabolism 2000;85(12):4889-99.
2000: Yeh-Chih Kao; T Higashiyama; X Sun; Tomoharu Okubo; C Yarborough; I Choi; Yoshio Osawa; F A Simmen; Shiuan Chen
Catalytic differences between porcine blastocyst and placental aromatase isozymes.
European journal of biochemistry / FEBS 2000;267(20):6134-9.
2000: Shiuan Chen; K Wu; R Knox
Structure-function studies of DT-diaphorase (NQO1) and NRH: quinone oxidoreductase (NQO2).
Free radical biology & medicine 2000;29(3-4):276-84.
2000: Richard J Knox; T C Jenkins; S M Hobbs; Shiuan Chen; RG Melton; Philip J Burke
Bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by human NAD(P)H quinone oxidoreductase 2: a novel co-substrate-mediated antitumor prodrug therapy.
Cancer research 2000;60(15):4179-86.
2000: Dujin Zhou; K M Quach; Chun Yang; S Y Lee; B Pohajdak; Shiuan Chen
PNRC: a proline-rich nuclear receptor coregulatory protein that modulates transcriptional activation of multiple nuclear receptors including orphan receptors SF1 (steroidogenic factor 1) and ERRalpha1 (estrogen related receptor alpha-1).
Molecular endocrinology (Baltimore, Md.) 2000;14(7):986-98.
1999: Dujin Zhou; Shiuan Chen
Identification and characterization of a cAMP-responsive element in the region upstream from promoter 1.3 of the human aromatase gene.
Archives of biochemistry and biophysics 1999;371(2):179-90.
1999: Chun Yang; Shiuan Chen
Two organochlorine pesticides, toxaphene and chlordane, are antagonists for estrogen-related receptor alpha-1 orphan receptor.
Cancer research 1999;59(18):4519-24.
1999: Shiuan Chen; K Wu; D Zhang; M Sherman; R Knox; C S Yang
Molecular characterization of binding of substrates and inhibitors to DT-diaphorase: combined approach involving site-directed mutagenesis, inhibitor-binding analysis, and computer modeling.
Molecular pharmacology 1999;56(2):272-8.
1999: Shiuan Chen; Dujin Zhou; Tomoharu Okubo; Yeh-Chih Kao; Chun Yang
Breast tumor aromatase: functional role and transcriptional regulation.
Endocrine-related cancer 1999;6(2):149-56.
1999: Yeh-Chih Kao; T Higashiyama; C Yarborough; Yoshio Osawa; Shiuan Chen
Functional characterization of 102-amino acid-deleted form of human aromatase (delta102-aromatase).
Steroids 1999;64(6):422-9.
1999: Yeh-Chih Kao; Tomoharu Okubo; X Z Sun; Shiuan Chen
Induction of aromatase expression by aminoglutethimide, an aromatase inhibitor that is used to treat breast cancer in postmenopausal women.
Anticancer research 1999;19(3A):2049-56.
1999: C H Rhee; Kenneth Hess; James R Jabbur; M Ruiz; Y Yang; Shiuan Chen; A Chenchik; Gregory N Fuller; Wei Zhang
cDNA expression array reveals heterogeneous gene expression profiles in three glioblastoma cell lines.
Oncogene 1999;18(17):2711-7.
1998: Chun Yang; Dujin Zhou; Shiuan Chen
Modulation of aromatase expression in the breast tissue by ERR alpha-1 orphan receptor.
Cancer research 1998;58(24):5695-700.
1998: Shiuan Chen
Aromatase and breast cancer.
Frontiers in bioscience : a journal and virtual library 1998;3():d922-33.
1998: Dujin Zhou; Shiuan Chen
Characterization of a silencer element in the human aromatase gene.
Archives of biochemistry and biophysics 1998;353(2):213-20.
1998: Yeh-Chih Kao; C Zhou; Mark Sherman; CA Laughton; Shiuan Chen
Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study.
Environmental health perspectives 1998;106(2):85-92.
1997: K Wu; R Knox; X Z Sun; P Joseph; Anil K Jaiswal; D Zhang; P S Deng; Shiuan Chen
Catalytic properties of NAD(P)H:quinone oxidoreductase-2 (NQO2), a dihydronicotinamide riboside dependent oxidoreductase.
Archives of biochemistry and biophysics 1997;347(2):221-8.
1997: X Z Sun; Dujin Zhou; Shiuan Chen
Autocrine and paracrine actions of breast tumor aromatase. A three-dimensional cell culture study involving aromatase transfected MCF-7 and T-47D cells.
The Journal of steroid biochemistry and molecular biology 1997;63(1-3):29-36.
1997: Dujin Zhou; C Zhou; Shiuan Chen
Gene regulation studies of aromatase expression in breast cancer and adipose stromal cells.
The Journal of steroid biochemistry and molecular biology 1997;61(3-6):273-80.
1997: Shiuan Chen; Yeh-Chih Kao; CA Laughton
Binding characteristics of aromatase inhibitors and phytoestrogens to human aromatase.
The Journal of steroid biochemistry and molecular biology 1997;61(3-6):107-15.
1997: Shiuan Chen; R Knox; K Wu; P S Deng; Dujin Zhou; Mario Antonio Bianchet; Mario Amzel
Molecular basis of the catalytic differences among DT-diaphorase of human, rat, and mouse.
The Journal of biological chemistry 1997;272(3):1437-9.
1996: C Zhou; Dujin Zhou; J Esteban; JT Murai; Pentti Siiteri; S Wilczynski; Shiuan Chen
Aromatase gene expression and its exon I usage in human breast tumors. Detection of aromatase messenger RNA by reverse transcription-polymerase chain reaction.
The Journal of steroid biochemistry and molecular biology 1996;59(2):163-71.
1996: Yeh-Chih Kao; L L Cam; C A Laughton; Dujin Zhou; Shiuan Chen
Binding characteristics of seven inhibitors of human aromatase: a site-directed mutagenesis study.
Cancer research 1996;56(15):3451-60.
1996: Dujin Zhou; P Clarke; J Wang; Shiuan Chen
Identification of a promoter that controls aromatase expression in human breast cancer and adipose stromal cells.
The Journal of biological chemistry 1996;271(25):15194-202.
1995: G Tedeschi; P S Deng; H H Chen; G L Forrest; V Massey; Shiuan Chen
A site-directed mutagenesis study at Lys-113 of NAD(P)H:quinone-acceptor oxidoreductase: an involvement of Lys-113 in the binding of the flavin adenine dinucleotide prosthetic group.
Archives of biochemistry and biophysics 1995;321(1):76-82.
1995: Shiuan Chen; R Knox; A D Lewis; Frank Friedlos; P Workman; P S Deng; M Fung; D Ebenstein; K Wu; T M Tsai
Catalytic properties of NAD(P)H:quinone acceptor oxidoreductase: study involving mouse, rat, human, and mouse-rat chimeric enzymes.
Molecular pharmacology 1995;47(5):934-9.
1995: Shiuan Chen; P S Deng; KM Swiderek; M Li; S I Chan
Interaction of flavones and their bromoacetyl derivatives with NAD(P)H:quinone acceptor oxidoreductase.
Molecular pharmacology 1995;47(2):419-24.
1994: Shiuan Chen; P E Clarke; P A Martino; P S Deng; C H Yeh; Terry D Lee; H J Prochaska; Paul Talalay
Mouse liver NAD(P)H:quinone acceptor oxidoreductase: protein sequence analysis by tandem mass spectrometry, cDNA cloning, expression in Escherichia coli, and enzyme activity analysis.
Protein science : a publication of the Protein Society 1994;3(8):1296-304.
1994: Dujin Zhou; L L Cam; C A Laughton; K R Korzekwa; Shiuan Chen
Mutagenesis study at a postulated hydrophobic region near the active site of aromatase cytochrome P450.
The Journal of biological chemistry 1994;269(30):19501-8.
1994: J Wang; Shiuan Chen
Induction of aromatase gene expression in human placental choriocarcinoma (JAR) cells by phorbol esters.
Biochimica et biophysica acta 1994;1218(1):48-54.
1994: Shiuan Chen; P S Deng; J M Bailey; KM Swiderek
A two-domain structure for the two subunits of NAD(P)H:quinone acceptor oxidoreductase.
Protein science : a publication of the Protein Society 1994;3(1):51-7.
1993: Dujin Zhou; J Wang; E Chen; JT Murai; Pentti Siiteri; Shiuan Chen
Aromatase gene is amplified in MCF-7 human breast cancer cells.
The Journal of steroid biochemistry and molecular biology 1993;46(2):147-53.
1993: Shiuan Chen; J Hwang; P S Deng
Inhibition of NAD(P)H:quinone acceptor oxidoreductase by flavones: a structure-activity study.
Archives of biochemistry and biophysics 1993;302(1):72-7.
1993: Shiuan Chen; Dujin Zhou; KM Swiderek; N Kadohama; Yoshio Osawa; P F Hall
Structure-function studies of human aromatase.
The Journal of steroid biochemistry and molecular biology 1993;44(4-6):347-56.
1992: Shiuan Chen; Dujin Zhou
Functional domains of aromatase cytochrome P450 inferred from comparative analyses of amino acid sequences and substantiated by site-directed mutagenesis experiments.
The Journal of biological chemistry 1992;267(31):22587-94.
1992: Shiuan Chen; X F Liu
Suggested mechanism for the modulation of the activity of NAD(P)H:quinone acceptor oxidoreductase (DT-diaphorase) by menadione: interpretation of the effect of menadione on 5'-[p-(Fluorosulfonyl)benzoyl]adenosine labeling of rat liver NAD(P)H:quinone acceptor oxidoreductase.
Molecular pharmacology 1992;42(3):545-48.
1992: J Wang; Shiuan Chen
Identification of a promoter and a silencer at the 3'-end of the first intron of the human aromatase gene.
Molecular endocrinology (Baltimore, Md.) 1992;6(9):1479-88.
1992: H H Chen; J X Ma; G L Forrest; P S Deng; P A Martino; Terry D Lee; Shiuan Chen
Expression of rat liver NAD(P)H:quinone-acceptor oxidoreductase in Escherichia coli and mutagenesis in vitro at Arg-177.
The Biochemical journal 1992;284 ( Pt 3)():855-60.
1992: K J Rutherfurd; KM Swiderek; Carla B Green; Shiuan Chen; John E Shively; S C Kwok
Purification and characterization of PSP-I and PSP-II, two major proteins from porcine seminal plasma.
Archives of biochemistry and biophysics 1992;295(2):352-9.
1992: J M Esteban; Z Warsi; M Haniu; P Hall; John E Shively; Shiuan Chen
Detection of intratumoral aromatase in breast carcinomas. An immunohistochemical study with clinicopathologic correlation.
The American journal of pathology 1992;140(2):337-43.
1990: P S Deng; Y Hatefi; Shiuan Chen
N-arylazido-beta-alanyl-NAD+, a new NAD+ photoaffinity analogue. Synthesis and labeling of mitochondrial NADH dehydrogenase.
Biochemistry 1990;29(4):1094-8.
1989: Denis POMPON; R Y Liu; M J Besman; P L Wang; John E Shively; Shiuan Chen
Expression of human placental aromatase in Saccharomyces cerevisiae.
Molecular endocrinology (Baltimore, Md.) 1989;3(9):1477-87.