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Shi Chen

Research Profile

Chemicals & Drugs

Living Beings

Physiology

Anatomy

Disorders

Genes & Molecular Sequences

Genes, Neurofibromatosis 1

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Publications

TOP 3
Yongzheng He; Li Jiang; Xianqi Li; Khalid S Mohammad; Steven D Rhodes; Naoyuki Takahashi; Xiaohua Wu; Mingjiang Xu; Shi Chen; Theresa A Guise; Xianlin Yang; Jin Yuan; Feng-Chun Yang
c-Fms signaling mediates neurofibromatosis Type-1 osteoclast gain-in-functions.
Xiaohua Wu; Xianlin Yang; Shi Chen; D Wade Clapp; Simon J Conway; Theresa A Guise; Yongzheng He; Li Jiang; Xiaohong Li; Khalid S Mohammad; Grzegorz Nalepa; Steven D Rhodes; Alexander G Robling; Paige Snider; Feng-Chun Yang
The haploinsufficient hematopoietic microenvironment is critical to the pathological fracture repair in murine models of neurofibromatosis type 1.
Shi Chen; Sarah Burgin; Andrew McDaniel; Xiaohong Li; Jin Yuan; Mia Chen; Waleed Khalaf; D Wade Clapp; Feng-Chun Yang
Nf1-/- Schwann cell-conditioned medium modulates mast cell degranulation by c-Kit-mediated hyperactivation of phosphatidylinositol 3-kinase.

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All Publications

2012: Yongzheng He; Li Jiang; Xianqi Li; Khalid S Mohammad; Steven D Rhodes; Naoyuki Takahashi; Xiaohua Wu; Mingjiang Xu; Shi Chen; Theresa A Guise; Xianlin Yang; Jin Yuan; Feng-Chun Yang
c-Fms signaling mediates neurofibromatosis Type-1 osteoclast gain-in-functions.
PloS one 2012;7(11):e46900.
2011: Xiaohua Wu; Xianlin Yang; Shi Chen; D Wade Clapp; Simon J Conway; Theresa A Guise; Yongzheng He; Li Jiang; Xiaohong Li; Khalid S Mohammad; Grzegorz Nalepa; Steven D Rhodes; Alexander G Robling; Paige Snider; Feng-Chun Yang
The haploinsufficient hematopoietic microenvironment is critical to the pathological fracture repair in murine models of neurofibromatosis type 1.
PloS one 2011;6(9):e24917.
2010: Shi Chen; Sarah Burgin; Andrew McDaniel; Xiaohong Li; Jin Yuan; Mia Chen; Waleed Khalaf; D Wade Clapp; Feng-Chun Yang
Nf1-/- Schwann cell-conditioned medium modulates mast cell degranulation by c-Kit-mediated hyperactivation of phosphatidylinositol 3-kinase.
The American journal of pathology 2010;177(6):3125-32.
2009: Huijie Li; Yaling Liu; Qi Zhang; Yongmin Jing; Shi Chen; Zhaohui Song; Jincheng Yan; Yan Li; Xiaohua Wu; Xianghong Zhang; Yingze Zhang; Jamie Case; Menggang Yu; David A Ingram; Feng-Chun Yang
Ras dependent paracrine secretion of osteopontin by Nf1+/- osteoblasts promote osteoclast activation in a neurofibromatosis type I murine model.
Pediatric research 2009;65(6):613-8.
2009: Jayme D Allen; Zahara M Jaffer; Su-Jung Park; Sarah Burgin; Clemens Hofmann; Mary Ann Sells; Shi Chen; Ethel Derr-Yellin; Elizabeth G Michels; Andrew McDaniel; Waylan K Bessler; David A Ingram; Simon J Atkinson; Jeffrey B Travers; Jonathan Chernoff; D Wade Clapp
p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics.
Blood 2009;113(12):2695-705.
2009: Michael L Goodman; Shi Chen; Feng-Chun Yang; Rebecca J Chan
Novel method of murine embryonic stem cell-derived osteoclast development.
Stem cells and development 2009;18(1):195-200.
2008: Veerendra Munugalavadla; Sasidhar Vemula; Emily Catherine Sims; Subha Krishnan; Shi Chen; Jincheng Yan; Huijie Li; Paul J Niziolek; Clifford M Takemoto; Alexander G Robling; Feng-Chun Yang; Reuben Kapur
The p85alpha subunit of class IA phosphatidylinositol 3-kinase regulates the expression of multiple genes involved in osteoclast maturation and migration.
Molecular and cellular biology 2008;28(23):7182-98.
2008: Feng-Chun Yang; David A Ingram; Shi Chen; Yuan Zhu; Jin Yuan; Xiaohong Li; Xianlin Yang; Scott Knowles; Whitney Horn; Yan Li; Shaobo Zhang; Yanzhu Yang; Saeed T Vakili; Menggang Yu; Dennis Burns; Kent Robertson; Gary Hutchins; Luis F Parada; D Wade Clapp
Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrow.
Cell 2008;135(3):437-48.
2008: Jincheng Yan; Shi Chen; Yingze Zhang; Xiaohong Li; Yan Li; Xiaohua Wu; Jin Yuan; Alexander G Robling; Reuben Kapur; Reuben Karpur; Rebecca J Chan; Feng-Chun Yang
Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1.
Human molecular genetics 2008;17(7):936-48.
2007: Todd D Nebesio; Wenyu Ming; Shi Chen; Travis Clegg; Jin Yuan; Yanzhu Yang; Selina A Estwick; Yan Li; Xiaohong Li; Cynthia M Hingtgen; Feng-Chun Yang
Neurofibromin-deficient Schwann cells have increased lysophosphatidic acid dependent survival and migration-implications for increased neurofibroma formation during pregnancy.
Glia 2007;55(5):527-36.
2007: Waleed Khalaf; Feng-Chun Yang; Shi Chen; Hilary White; Waylan Bessler; David A Ingram; D Wade Clapp
K-ras is critical for modulating multiple c-kit-mediated cellular functions in wild-type and Nf1+/- mast cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(4):2527-34.
2006: Yue Si; Samantha L M Ciccone; Feng-Chun Yang; Jin Yuan; Daisy Zeng; Shi Chen; Henri J van de Vrugt; John K Critser; Fré Arwert; Laura S Haneline; D Wade Clapp
Continuous in vivo infusion of interferon-gamma (IFN-gamma) enhances engraftment of syngeneic wild-type cells in Fanca-/- and Fancg-/- mice.
Blood 2006;108(13):4283-7.
2006: Feng-Chun Yang; Shi Chen; Alexander G Robling; Xijie Yu; Todd D Nebesio; Jincheng Yan; Trent Morgan; Xiaohong Li; Jin Yuan; Janet Hock; David A Ingram; D Wade Clapp
Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions.
The Journal of clinical investigation 2006;116(11):2880-91.
2006: Xiaohua Wu; Selina A Estwick; Shi Chen; Menggang Yu; Wenyu Ming; Todd D Nebesio; Yan Li; Jin Yuan; Reuben Kapur; David Ingram; Mervin C Yoder; Feng-Chun Yang
Neurofibromin plays a critical role in modulating osteoblast differentiation of mesenchymal stem/progenitor cells.
Human molecular genetics 2006;15(19):2837-45.
2006: Feng-Chun Yang; Shi Chen; Travis Clegg; Xiaohong Li; Trent Morgan; Selina A Estwick; Jin Yuan; Waleed Khalaf; Sarah Burgin; Jeff Travers; Luis F Parada; David A Ingram; D Wade Clapp
Nf1+/- mast cells induce neurofibroma like phenotypes through secreted TGF-beta signaling.
Human molecular genetics 2006;15(16):2421-37.
2006: Fang Li; Amy M Munchhof; Hilary A White; Laura E Mead; Theresa R Krier; Amy Fenoglio; Shi Chen; Xiaohua Wu; Shanbao Cai; Feng-Chun Yang; David A Ingram
Neurofibromin is a novel regulator of RAS-induced signals in primary vascular smooth muscle cells.
Human molecular genetics 2006;15(11):1921-30.
2006: Laura S Haneline; Hilary White; Feng-Chun Yang; Shi Chen; Christie M Orschell; Reuben Kapur; David A Ingram
Genetic reduction of class IA PI-3 kinase activity alters fetal hematopoiesis and competitive repopulating ability of hematopoietic stem cells in vivo.
Blood 2006;107(4):1375-82.
2005: Xijie Yu; Shi Chen; O L Potter; S M Murthy; Jiliang Li; J M Pulcini; Naoko Ohashi; Therry Winata; Eric Everett; David Ingram; W D Clapp; Janet Hock
Neurofibromin and its inactivation of Ras are prerequisites for osteoblast functioning.
Bone 2005;36(5):793-802.
2005: Xiaxin Li; Michelle M Le Beau; Samantha L M Ciccone; Feng-Chun Yang; Brian Freie; Shi Chen; Jin Yuan; Ping Hong; Attilio Orazi; Laura S Haneline; D Wade Clapp
Ex vivo culture of Fancc-/- stem/progenitor cells predisposes cells to undergo apoptosis, and surviving stem/progenitor cells display cytogenetic abnormalities and an increased risk of malignancy.
Blood 2005;105(9):3465-71.
2003: Feng-Chun Yang; David A Ingram; Shi Chen; Cynthia M Hingtgen; Nancy Ratner; Kelly R Monk; Travis Clegg; Hilary White; Laura E Mead; Mary Jo Wenning; David A Williams; Reuben Kapur; Simon J Atkinson; D Wade Clapp
Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cells.
The Journal of clinical investigation 2003;112(12):1851-61.