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Xiongwen Chen

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Xiaoying Zhang; Lin Zhou; Xiaojie Ai; Qin Fu; Erhe Gao; Hui Gao; Xinyi Joy Ge; Jianguo Jin; Satya P Kunapuli; Ying Li; Catherine Makarewich; Christopher Szeto; Allen Tang; Mingxin Tang; Fang Wang; Jenny Wang; Kevin Yang Xiang; Chunyu Zeng; Xiongwen Chen
Cardiotoxic and cardioprotective features of chronic β-adrenergic signaling.
Hongyu Zhang; Remus M Berretta; Xiongwen Chen; Jason M Duran; Erhe Gao; Walter J Koch; Hajime Kubo; Ying Li; Catherine A Makarewich; Héctor H Valdivia; Wei Wang; Steven R Houser
Hyperphosphorylation of the cardiac ryanodine receptor at serine 2808 is not involved in cardiac dysfunction after myocardial infarction.
Yingxin Li; Zhao Qi; Christopher Szeto; Mingxin Tang; Fang Wang; Hongyu Zhang; Xiaoying Zhang; Ying Li; Xiongwen Chen
β-Adrenergic stimulation increases Cav3.1 activity in cardiac myocytes through protein kinase A.

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All Publications

2013: Xiaoying Zhang; Lin Zhou; Xiaojie Ai; Qin Fu; Erhe Gao; Hui Gao; Xinyi Joy Ge; Jianguo Jin; Satya P Kunapuli; Ying Li; Catherine Makarewich; Christopher Szeto; Allen Tang; Mingxin Tang; Fang Wang; Jenny Wang; Kevin Yang Xiang; Chunyu Zeng; Xiongwen Chen
Cardiotoxic and cardioprotective features of chronic β-adrenergic signaling.
Circulation research 2013;112(3):498-509.
2012: Hongyu Zhang; Remus M Berretta; Xiongwen Chen; Jason M Duran; Erhe Gao; Walter J Koch; Hajime Kubo; Ying Li; Catherine A Makarewich; Héctor H Valdivia; Wei Wang; Steven R Houser
Hyperphosphorylation of the cardiac ryanodine receptor at serine 2808 is not involved in cardiac dysfunction after myocardial infarction.
Circulation research 2012;110(6):831-40.
2012: Yingxin Li; Zhao Qi; Christopher Szeto; Mingxin Tang; Fang Wang; Hongyu Zhang; Xiaoying Zhang; Ying Li; Xiongwen Chen
β-Adrenergic stimulation increases Cav3.1 activity in cardiac myocytes through protein kinase A.
PloS one 2012;7(7):e39965.
2011: David Angert; Remus M Berretta; Hajime Kubo; Hongyu Zhang; Xiongwen Chen; Wei Wang; Barbara Ogorek; Mary F Barbe; Steven R Houser
Repair of the injured adult heart involves new myocytes potentially derived from resident cardiac stem cells.
Circulation research 2011;108(10):1226-37.
2011: Xiongwen Chen; Hiroyuki Nakayama; Xiaoying Zhang; Xiaojie Ai; David M Harris; Mingxin Tang; Hongyu Zhang; Christopher Szeto; Kathryn Stockbower; Remus M Berretta; Andrea D Eckhart; Walter J Koch; Jeffery D Molkentin; Steven R Houser
Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy.
Journal of molecular and cellular cardiology 2011;50(3):460-70.
2010: Hongyu Zhang; Xiongwen Chen; Erhe Gao; Scott M MacDonnell; Wei Wang; Mikhail Kolpakov; Hiroyuki Nakayama; Xiaoying Zhang; Naser Jaleel; David M Harris; Yingxin Li; Mingxin Tang; Remus M Berretta; Annarosa Leri; Jan Kajstura; Abdelkarim Sabri; Walter J Koch; Jeffery D Molkentin; Steven R Houser
Increasing cardiac contractility after myocardial infarction exacerbates cardiac injury and pump dysfunction.
Circulation research 2010;107(6):800-9.
2010: Mingxin Tang; Xiaoying Zhang; Yingxin Li; Yinzheng Guan; Xiaojie Ai; Christopher Szeto; Hiroyuki Nakayama; Hongyu Zhang; Shuping Ge; Jeffery D Molkentin; Steven R Houser; Xiongwen Chen
Enhanced basal contractility but reduced excitation-contraction coupling efficiency and beta-adrenergic reserve of hearts with increased Cav1.2 activity.
American journal of physiology. Heart and circulatory physiology 2010;299(2):H519-28.
2010: Wei Wang; Hongyu Zhang; Hui Gao; Hajime Kubo; Remus M Berretta; Xiongwen Chen; Steven R Houser
{beta}1-Adrenergic receptor activation induces mouse cardiac myocyte death through both L-type calcium channel-dependent and -independent pathways.
American journal of physiology. Heart and circulatory physiology 2010;299(2):H322-31.
2010: Jibin Zhou; Hind Lal; Xiongwen Chen; Xiying Shang; Jianliang Song; Yingxin Li; Risto Kerkela; Bradley Doble; Katrina MacAulay; Morgan DeCaul; Walter J Koch; John Farber; James R Woodgett; Erhe Gao; Thomas Force
GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice.
The Journal of clinical investigation 2010;120(7):2280-91.
2009: Scott M MacDonnell; Jutta Weisser-Thomas; Hajime Kubo; Marie Hanscome; Qinghang Liu; Naser Jaleel; Remus M Berretta; Xiongwen Chen; Joan H Brown; Abdel-Karim Sabri; Jeffery D Molkentin; Steven R Houser
CaMKII negatively regulates calcineurin-NFAT signaling in cardiac myocytes.
Circulation research 2009;105(4):316-25.
2008: Naser Jaleel; Hiroyuki Nakayama; Xiongwen Chen; Hajime Kubo; Scott M MacDonnell; Hongyu Zhang; Remus M Berretta; Jeffrey Robbins; Leanne Cribbs; Jeffery D Molkentin; Steven R Houser
Ca2+ influx through T- and L-type Ca2+ channels have different effects on myocyte contractility and induce unique cardiac phenotypes.
Circulation research 2008;103(10):1109-19.
2008: Philip W Raake; Leif Erik Vinge; Erhe Gao; Matthieu Boucher; Giuseppe Rengo; Xiongwen Chen; Brent R DeGeorge; Scot Matkovich; Steven R Houser; Patrick Most; Andrea D Eckhart; Gerald W Dorn; Walter J Koch
G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure.
Circulation research 2008;103(4):413-22.
2008: Xiongwen Chen; Xiaoying Zhang; David M Harris; Valentino Piacentino; Remus M Berretta; Kenneth B Margulies; Steven R Houser
Reduced effects of BAY K 8644 on L-type Ca2+ current in failing human cardiac myocytes are related to abnormal adrenergic regulation.
American journal of physiology. Heart and circulatory physiology 2008;294(5):H2257-67.
2008: Scott M MacDonnell; Gerardo García-Rivas; Joseph A Scherman; Hajime Kubo; Xiongwen Chen; Héctor Valdivia; Steven R Houser
Adrenergic regulation of cardiac contractility does not involve phosphorylation of the cardiac ryanodine receptor at serine 2808.
Circulation research 2008;102(8):e65-72.
2007: Marcello Rota; Jan Kajstura; Toru Hosoda; Claudia Bearzi; Serena Vitale; Grazia Esposito; Grazia Iaffaldano; Maria Elena Padin-Iruegas; Arantxa Gonzalez; Roberto Rizzi; Narissa Small; John Muraski; Roberto Alvarez; Xiongwen Chen; Konrad Urbanek; Roberto Bolli; Steven R Houser; Annarosa Leri; Mark A Sussman; Piero Anversa
Bone marrow cells adopt the cardiomyogenic fate in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(45):17783-8.
2007: Scott M MacDonnell; Hajime Kubo; David M Harris; Xiongwen Chen; Remus M Berretta; Mary F Barbe; Stephen Kolwicz; Patricia O Reger; Andrea D Eckhart; Brian F Renna; Walter J Koch; Steven R Houser; Joseph R Libonati
Calcineurin inhibition normalizes beta-adrenergic responsiveness in the spontaneously hypertensive rat.
American journal of physiology. Heart and circulatory physiology 2007;293(5):H3122-9.
2007: Xiongwen Chen; Rachel M Wilson; Hajime Kubo; Remus M Berretta; David M Harris; Xiaoying Zhang; Naser Jaleel; Scott M MacDonnell; Claudia Bearzi; Jochen Tillmanns; Irina Trofimova; Toru Hosoda; Federico Mosna; Leanne Cribbs; Annarosa Leri; Jan Kajstura; Piero Anversa; Steven R Houser
Adolescent feline heart contains a population of small, proliferative ventricular myocytes with immature physiological properties.
Circulation research 2007;100(4):536-44.
2007: Geoffrey D Mills; David M Harris; Xiongwen Chen; Steven R Houser
Intracellular sodium determines frequency-dependent alterations in contractility in hypertrophied feline ventricular myocytes.
American journal of physiology. Heart and circulatory physiology 2007;292(2):H1129-38.
2006: Hajime Funakoshi; Tung O Chan; Julie C Good; Joseph R Libonati; Jarkko Piuhola; Xiongwen Chen; Scott M MacDonnell; Ling L Lee; David E Herrmann; Jin Zhang; Jeffrey Martini; Timothy Palmer; Atsushi Sanbe; Jeffrey Robbins; Steven R Houser; Walter J Koch; Arthur M Feldman
Regulated overexpression of the A1-adenosine receptor in mice results in adverse but reversible changes in cardiac morphology and function.
Circulation 2006;114(21):2240-50.
2005: Xiongwen Chen; Xiaoying Zhang; Hajime Kubo; David M Harris; Geoffrey D Mills; Jed Moyer; Remus M Berretta; Sabine Telemaque Potts; James D Marsh; Steven R Houser
Ca2+ influx-induced sarcoplasmic reticulum Ca2+ overload causes mitochondrial-dependent apoptosis in ventricular myocytes.
Circulation research 2005;97(10):1009-17.
2005: David M Harris; Geoffrey D Mills; Xiongwen Chen; Hajime Kubo; Remus M Berretta; V Scott Votaw; Luis F Santana; Steven R Houser
Alterations in early action potential repolarization causes localized failure of sarcoplasmic reticulum Ca2+ release.
Circulation research 2005;96(5):543-50.
2003: Valentino Piacentino; Christopher R Weber; Xiongwen Chen; Jutta Weisser-Thomas; Kenneth B Margulies; Donald M Bers; Steven R Houser
Cellular basis of abnormal calcium transients of failing human ventricular myocytes.
Circulation research 2003;92(6):651-8.
2002: Xiongwen Chen; Valentino Piacentino; Satoshi Furukawa; Bruce Goldman; Kenneth B Margulies; Steven R Houser
L-type Ca2+ channel density and regulation are altered in failing human ventricular myocytes and recover after support with mechanical assist devices.
Circulation research 2002;91(6):517-24.
2001: Guenther Boden; Xiongwen Chen; E Capulong; Maria Mozzoli
Effects of free fatty acids on gluconeogenesis and autoregulation of glucose production in type 2 diabetes.
Diabetes 2001;50(4):810-6.
2001: Carol J Homko; Eyal Sivan; Xiongwen Chen; E Albert Reece; Guenther Boden
Insulin secretion during and after pregnancy in patients with gestational diabetes mellitus.
The Journal of clinical endocrinology and metabolism 2001;86(2):568-73.
2001: Guenther Boden; Xiongwen Chen; Peter T Stein
Gluconeogenesis in moderately and severely hyperglycemic patients with type 2 diabetes mellitus.
American journal of physiology. Endocrinology and metabolism 2001;280(1):E23-30.
1999: Guenther Boden; Xiongwen Chen; Marcia Polansky
Disruption of circadian insulin secretion is associated with reduced glucose uptake in first-degree relatives of patients with type 2 diabetes.
Diabetes 1999;48(11):2182-8.
1999: A Koneti Rao; VD Chouhan; Xiongwen Chen; L Sun; Guenther Boden
Activation of the tissue factor pathway of blood coagulation during prolonged hyperglycemia in young healthy men.
Diabetes 1999;48(5):1156-61.
1999: Eyal Sivan; Carol J Homko; Xiongwen Chen; E Albert Reece; Guenther Boden
Effect of insulin on fat metabolism during and after normal pregnancy.
Diabetes 1999;48(4):834-8.
1999: Guenther Boden; Xiongwen Chen
Effects of fatty acids and ketone bodies on basal insulin secretion in type 2 diabetes.
Diabetes 1999;48(3):577-83.
1999: Xiongwen Chen; N Iqbal; Guenther Boden
The effects of free fatty acids on gluconeogenesis and glycogenolysis in normal subjects.
The Journal of clinical investigation 1999;103(3):365-72.
1998: Guenther Boden; Xiongwen Chen; N Iqbal
Acute lowering of plasma fatty acids lowers basal insulin secretion in diabetic and nondiabetic subjects.
Diabetes 1998;47(10):1609-12.
1997: Guenther Boden; Xiongwen Chen; Jerzy W Kolaczynski; M Polansky
Effects of prolonged hyperinsulinemia on serum leptin in normal human subjects.
The Journal of clinical investigation 1997;100(5):1107-13.
1996: Guenther Boden; Xiongwen Chen; M Mozzoli; I Ryan
Effect of fasting on serum leptin in normal human subjects.
The Journal of clinical endocrinology and metabolism 1996;81(9):3419-23.
1996: Guenther Boden; Xiongwen Chen; J Ruiz; G D van Rossum; S Turco
Effects of vanadyl sulfate on carbohydrate and lipid metabolism in patients with non-insulin-dependent diabetes mellitus.
Metabolism: clinical and experimental 1996;45(9):1130-5.
1996: Guenther Boden; J Ruiz; JL Urbain; Xiongwen Chen
Evidence for a circadian rhythm of insulin secretion.
The American journal of physiology 1996;271(2 Pt 1):E246-52.
1996: Guenther Boden; Xiongwen Chen; JL Urbain
Evidence for a circadian rhythm of insulin sensitivity in patients with NIDDM caused by cyclic changes in hepatic glucose production.
Diabetes 1996;45(8):1044-50.
1996: Guenther Boden; J Ruiz; C J Kim; Xiongwen Chen
Effects of prolonged glucose infusion on insulin secretion, clearance, and action in normal subjects.
The American journal of physiology 1996;270(2 Pt 1):E251-8.
1995: Xiongwen Chen; J Ruiz; Guenther Boden
Release, oxidation, and reesterification of fatty acids from infused triglycerides: effect of heparin.
Metabolism: clinical and experimental 1995;44(12):1590-5.
1995: Guenther Boden; Xiongwen Chen; J Rosner; M Barton
Effects of a 48-h fat infusion on insulin secretion and glucose utilization.
Diabetes 1995;44(10):1239-42.
1995: Guenther Boden; Xiongwen Chen
Effects of fat on glucose uptake and utilization in patients with non-insulin-dependent diabetes.
The Journal of clinical investigation 1995;96(3):1261-8.
1994: Guenther Boden; Xiongwen Chen; J Ruiz; J V White; L Rossetti
Mechanisms of fatty acid-induced inhibition of glucose uptake.
The Journal of clinical investigation 1994;93(6):2438-46.
1994: Guenther Boden; Xiongwen Chen; J Ruiz; M Heifets; M Morris; F Badosa
Insulin receptor down-regulation and impaired antilipolytic action of insulin in diabetic patients after pancreas/kidney transplantation.
The Journal of clinical endocrinology and metabolism 1994;78(3):657-63.
1993: Guenther Boden; Xiongwen Chen; R A Desantis; Z Kendrick
Effects of insulin on fatty acid reesterification in healthy subjects.
Diabetes 1993;42(11):1588-93.
1993: Guenther Boden; Xiongwen Chen; R A DeSantis; Z Kendrick
Ethanol inhibits insulin action on lipolysis and on insulin release in elderly men.
The American journal of physiology 1993;265(2 Pt 1):E197-202.
1993: Guenther Boden; Xiongwen Chen; R DeSantis; J Kolaczynski; M Morris
Evidence that suppression of insulin secretion by insulin itself is neurally mediated.
Metabolism: clinical and experimental 1993;42(6):786-9.
1993: Guenther Boden; R DeSantis; Xiongwen Chen; M Morris; F Badoza
Glucose metabolism and leg blood flow after pancreas/kidney transplantation.
The Journal of clinical endocrinology and metabolism 1993;76(5):1229-33.
1993: Guenther Boden; Xiongwen Chen; R A DeSantis; Z Kendrick
Effects of age and body fat on insulin resistance in healthy men.
Diabetes care 1993;16(5):728-33.
1993: Guenther Boden; Xiongwen Chen; R Desantis; J White; M Mozzoli
Effects of ethanol on carbohydrate metabolism in the elderly.
Diabetes 1993;42(1):28-34.
1991: Guenther Boden; F Jadali; J White; Y Liang; M Mozzoli; Xiongwen Chen; E Coleman; C Smith
Effects of fat on insulin-stimulated carbohydrate metabolism in normal men.
The Journal of clinical investigation 1991;88(3):960-6.