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Xi-Lin Chen

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Xi-Lin Chen; Geraldine Dodd; Charles Kunsch
Sulforaphane inhibits TNF-alpha-induced activation of p38 MAP kinase and VCAM-1 and MCP-1 expression in endothelial cells.
Xi-Lin Chen; Geraldine Dodd; Suzanne Thomas; Xiaolan Zhang; Martin A Wasserman; Brad H Rovin; Charles Kunsch
Activation of Nrf2/ARE pathway protects endothelial cells from oxidant injury and inhibits inflammatory gene expression.
Charles Kunsch; Jayraz Luchoomun; Xi-Lin Chen; Geraldine L Dodd; Kanika S Karu; Charles Q Meng; Elaine M Marino; Lynda K Olliff; J Daniel Piper; Fei-Hua Qiu; James A Sikorski; Patricia K Somers; Ki-Ling Suen; Suzanne Thomas; Anne M Whalen; Martin A Wasserman; Cynthia L Sundell
AGIX-4207 [2-[4-[[1-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-1-methylethyl]thio]-2,6-bis(1,1-dimethylethyl)phenoxy]acetic acid], a novel antioxidant and anti-inflammatory compound: cellular and biochemical characterization of antioxidant activity and inhibition of redox-sensitive inflammatory gene expression.

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All Publications

2009: Xi-Lin Chen; Geraldine Dodd; Charles Kunsch
Sulforaphane inhibits TNF-alpha-induced activation of p38 MAP kinase and VCAM-1 and MCP-1 expression in endothelial cells.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2009;58(8):513-21.
2006: Xi-Lin Chen; Geraldine Dodd; Suzanne Thomas; Xiaolan Zhang; Martin A Wasserman; Brad H Rovin; Charles Kunsch
Activation of Nrf2/ARE pathway protects endothelial cells from oxidant injury and inhibits inflammatory gene expression.
American journal of physiology. Heart and circulatory physiology 2006;290(5):H1862-70.
2005: Charles Kunsch; Jayraz Luchoomun; Xi-Lin Chen; Geraldine L Dodd; Kanika S Karu; Charles Q Meng; Elaine M Marino; Lynda K Olliff; J Daniel Piper; Fei-Hua Qiu; James A Sikorski; Patricia K Somers; Ki-Ling Suen; Suzanne Thomas; Anne M Whalen; Martin A Wasserman; Cynthia L Sundell
AGIX-4207 [2-[4-[[1-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-1-methylethyl]thio]-2,6-bis(1,1-dimethylethyl)phenoxy]acetic acid], a novel antioxidant and anti-inflammatory compound: cellular and biochemical characterization of antioxidant activity and inhibition of redox-sensitive inflammatory gene expression.
The Journal of pharmacology and experimental therapeutics 2005;313(2):492-501.
2004: Xi-Lin Chen; Janice Y Grey; Suzanne Thomas; Fei-Hua Qiu; Russell Medford; Martin A Wasserman; Charles Kunsch
Sphingosine kinase-1 mediates TNF-alpha-induced MCP-1 gene expression in endothelial cells: upregulation by oscillatory flow.
American journal of physiology. Heart and circulatory physiology 2004;287(4):H1452-8.
2004: Xi-Lin Chen; Charles Kunsch
Induction of cytoprotective genes through Nrf2/antioxidant response element pathway: a new therapeutic approach for the treatment of inflammatory diseases.
Current pharmaceutical design 2004;10(8):879-91.
2003: Xi-Lin Chen; Qiang Zhang; Ruozhi Zhao; Xiaoyu Ding; Pradyumna E Tummala; Russell Medford
Rac1 and superoxide are required for the expression of cell adhesion molecules induced by tumor necrosis factor-alpha in endothelial cells.
The Journal of pharmacology and experimental therapeutics 2003;305(2):573-80.
2003: Xi-Lin Chen; Signe E Varner; Anjali S Rao; Janice Y Grey; Suzanne Thomas; Christopher K Cook; Martin A Wasserman; Russell Medford; Anil K Jaiswal; Charles Kunsch
Laminar flow induction of antioxidant response element-mediated genes in endothelial cells. A novel anti-inflammatory mechanism.
The Journal of biological chemistry 2003;278(2):703-11.
2000: Pradyumna E Tummala; Xi-Lin Chen; Russell Medford
NF- kappa B independent suppression of endothelial vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 gene expression by inhibition of flavin binding proteins and superoxide production.
Journal of molecular and cellular cardiology 2000;32(8):1499-508.
1999: Pradyumna E Tummala; Xi-Lin Chen; Cynthia L Sundell; JB Laursen; C P Hammes; Wayne R Alexander; David G Harrison; Russell Medford
Angiotensin II induces vascular cell adhesion molecule-1 expression in rat vasculature: A potential link between the renin-angiotensin system and atherosclerosis.
Circulation 1999;100(11):1223-9.
1998: Xi-Lin Chen; Pradyumna E Tummala; M T Olbrych; Wayne R Alexander; Russell Medford
Angiotensin II induces monocyte chemoattractant protein-1 gene expression in rat vascular smooth muscle cells.
Circulation research 1998;83(9):952-9.
1997: Xi-Lin Chen; Pradyumna E Tummala; Lynda K Olliff; Russell Medford
E-selectin gene expression in vascular smooth muscle cells. Evidence for a tissue-specific repressor protein.
Circulation research 1997;80(3):305-11.