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Yihui Chen

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M Gil; Ravindra K Pandey; M Seshadri; M Bieniasz; Yihui Chen; Michael J Ciesielski; D Fisher; Danuta Kozbor
Photodynamic therapy augments the efficacy of oncolytic vaccinia virus against primary and metastatic tumours in mice.
Avinash Srivatsan; Krishnakumar Thankppan; Erin Tracy; Yanfang Wang; Heinz Baumann; Yihui Chen; Penny Joshi; Chao Liu; Joseph R Missert; Janet Morgan; Nestor Rigual; Munawwar Sajjad; Ravindra K Pandey
In vitro cellular uptake and dimerization of signal transducer and activator of transcription-3 (STAT3) identify the photosensitizing and imaging-potential of isomeric photosensitizers derived from chlorophyll-a and bacteriochlorophyll-a.
Manivannan Ethirajan; Yihui Chen; Penny Joshi; Ravindra K Pandey
The role of porphyrin chemistry in tumor imaging and photodynamic therapy.

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All Publications

2011: M Gil; Ravindra K Pandey; M Seshadri; M Bieniasz; Yihui Chen; Michael J Ciesielski; D Fisher; Danuta Kozbor
Photodynamic therapy augments the efficacy of oncolytic vaccinia virus against primary and metastatic tumours in mice.
British journal of cancer 2011;105(10):1512-21.
2011: Avinash Srivatsan; Krishnakumar Thankppan; Erin Tracy; Yanfang Wang; Heinz Baumann; Yihui Chen; Penny Joshi; Chao Liu; Joseph R Missert; Janet Morgan; Nestor Rigual; Munawwar Sajjad; Ravindra K Pandey
In vitro cellular uptake and dimerization of signal transducer and activator of transcription-3 (STAT3) identify the photosensitizing and imaging-potential of isomeric photosensitizers derived from chlorophyll-a and bacteriochlorophyll-a.
Journal of medicinal chemistry 2011;54(19):6859-73.
2011: Manivannan Ethirajan; Yihui Chen; Penny Joshi; Ravindra K Pandey
The role of porphyrin chemistry in tumor imaging and photodynamic therapy.
Chemical Society reviews 2011;40(1):340-62.
2010: Lalit N Goswami; William H White; Joseph A Spernyak; Manivannan Ethirajan; Yihui Chen; Joseph R Missert; Janet Morgan; richard mazurchuk; Ravindra K Pandey
Synthesis of Tumor-avid Photosensitizer-Gd(III)DTPA conjugates: impact of the number of gadolinium units in T1/T2 relaxivity, intracellular localization, and photosensitizing efficacy.
Bioconjugate chemistry 2010;21(5):816-27.
2010: Joseph A Spernyak; William H White; Manivannan Ethirajan; Nayan J Patel; Lalit Goswami; Yihui Chen; Steven Turowski; Joseph R Missert; Carrie Batt; richard mazurchuk; Ravindra K Pandey
Hexylether derivative of pyropheophorbide-a (HPPH) on conjugating with 3gadolinium(III) aminobenzyldiethylenetriaminepentaacetic acid shows potential for in vivo tumor imaging (MR, Fluorescence) and photodynamic therapy.
Bioconjugate chemistry 2010;21(5):828-35.
2010: Ravindra K Pandey; Nadine S James; Yihui Chen; Joseph Missert; Munawar Sajjad
Bifunctional agents for imaging and therapy.
Methods in molecular biology (Clifton, N.J.) 2010;635():223-59.
2009: Xiang Zheng; Janet Morgan; Suresh K Pandey; Yihui Chen; Erin Tracy; Heinz Baumann; Joseph R Missert; Carrie Batt; Jennifer Jackson; David A Bellnier; Barbara W Henderson; Ravindra K Pandey
Conjugation of 2-(1'-hexyloxyethyl)-2-devinylpyropheophorbide-a (HPPH) to carbohydrates changes its subcellular distribution and enhances photodynamic activity in vivo.
Journal of medicinal chemistry 2009;52(14):4306-18.
2009: Suresh K Pandey; Munawwar Sajjad; Yihui Chen; Anupam Pandey; Joseph R Missert; Carrie Batt; Rutao Yao; Hani A Nabi; Allan R Oseroff; Ravindra K Pandey
Compared to purpurinimides, the pyropheophorbide containing an iodobenzyl group showed enhanced PDT efficacy and tumor imaging (124I-PET) ability.
Bioconjugate chemistry 2009;20(2):274-82.
2009: Suresh K Pandey; Munawwar Sajjad; Yihui Chen; Xiang Zheng; Rutao Yao; Joseph R Missert; Carrie Batt; Hani A Nabi; Allan R Oseroff; Ravindra K Pandey
Comparative positron-emission tomography (PET) imaging and phototherapeutic potential of 124I- labeled methyl- 3-(1'-iodobenzyloxyethyl)pyropheophorbide-a vs the corresponding glucose and galactose conjugates.
Journal of medicinal chemistry 2009;52(2):445-55.
2007: Yihui Chen; Kei Ohkubo; Min Zhang; E Wenbo; Weiguo Liu; Suresh K Pandey; Michael J Ciesielski; Heinz Baumann; Tracy Erin; Shunichi Fukuzumi; Karl M Kadish; Robert A Fenstermaker; Allan R Oseroff; Ravindra K Pandey
Photophysical, electrochemical characteristics and cross-linking of STAT-3 protein by an efficient bifunctional agent for fluorescence image-guided photodynamic therapy.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2007;6(12):1257-67.
2007: Tymish Ohulchanskyy; Indrajit Roy; Lalit N Goswami; Yihui Chen; Earl J Bergey; Ravindra K Pandey; Allan R Oseroff; Paras N Prasad
Organically modified silica nanoparticles with covalently incorporated photosensitizer for photodynamic therapy of cancer.
Nano letters 2007;7(9):2835-42.
2007: Yihui Chen; William Potter; Joseph R Missert; Janet Morgan; Ravindra K Pandey
Comparative in vitro and in vivo studies on long-wavelength photosensitizers derived from bacteriopurpurinimide and Bacteriochlorin p6: fused imide ring enhances the in vivo PDT efficacy.
Bioconjugate chemistry 2007;18(5):1460-73.
2007: Amy Gryshuk; Yihui Chen; Lalit N Goswami; Suresh Pandey; Joseph R Missert; Tymish Ohulchanskyy; William Potter; Paras N Prasad; Allan R Oseroff; Ravindra K Pandey
Structure-activity relationship among purpurinimides and bacteriopurpurinimides: trifluoromethyl substituent enhanced the photosensitizing efficacy.
Journal of medicinal chemistry 2007;50(8):1754-67.
2006: Ravindra K Pandey; Lalit N Goswami; Yihui Chen; Amy Gryshuk; Joseph R Missert; Allan R Oseroff; Thomas J Dougherty
Nature: a rich source for developing multifunctional agents. Tumor-imaging and photodynamic therapy.
Lasers in surgery and medicine 2006;38(5):445-67.
2006: Amy Gryshuk; Yihui Chen; William Potter; Tymish Ohulchanskyy; Allan R Oseroff; Ravindra K Pandey
In vivo stability and photodynamic efficacy of fluorinated bacteriopurpurinimides derived from bacteriochlorophyll-a.
Journal of medicinal chemistry 2006;49(6):1874-81.
2006: Andrei Kozyrev; Yihui Chen; Lalit N Goswami; Walter A Tabaczynski; Ravindra K Pandey
Characterization of porphyrins, chlorins, and bacteriochlorins formed via allomerization of bacteriochlorophyll a. Synthesis of highly stable bacteriopurpurinimides and their metal complexes.
The Journal of organic chemistry 2006;71(5):1949-60.
2005: Suresh K Pandey; Amy Gryshuk; Munawwar Sajjad; Xiang Zheng; Yihui Chen; Mohei M Abouzeid; Janet Morgan; Ivan Charamisinau; Hani A Nabi; Allan R Oseroff; Ravindra K Pandey
Multimodality agents for tumor imaging (PET, fluorescence) and photodynamic therapy. A possible "see and treat" approach.
Journal of medicinal chemistry 2005;48(20):6286-95.
2005: Yihui Chen; Amy Gryshuk; Samuel achilefu; Tymish Ohulchanskyy; William Potter; Tuoxiu Zhong; Janet Morgan; Britton Chance; Paras N Prasad; Barbara W Henderson; Allan R Oseroff; Ravindra K Pandey
A novel approach to a bifunctional photosensitizer for tumor imaging and phototherapy.
Bioconjugate chemistry 2005;16(5):1264-74.
2005: Yihui Chen; Razvan Miclea; Thamarapu Srikrishnan; Sathyamangalam Balasubramanian; Thomas J Dougherty; Ravindra K Pandey
Investigation of human serum albumin (HSA) binding specificity of certain photosensitizers related to pyropheophorbide-a and bacteriopurpurinimide by circular dichroism spectroscopy and its correlation with in vivo photosensitizing efficacy.
Bioorganic & medicinal chemistry letters 2005;15(13):3189-92.
2005: Yihui Chen; Xiang Zheng; Mahabeer P Dobhal; Amy Gryshuk; Janet Morgan; Thomas J Dougherty; Allan R Oseroff; Ravindra K Pandey
Methyl pyropheophorbide-a analogues: potential fluorescent probes for the peripheral-type benzodiazepine receptor. Effect of central metal in photosensitizing efficacy.
Journal of medicinal chemistry 2005;48(11):3692-5.
2005: Guolin Li; Adam Slansky; Mahabeer P Dobhal; Lalit N Goswami; Andrew Graham; Yihui Chen; Peter Kanter; Ronald A Alberico; Joseph Spernyak; Janet Morgan; richard mazurchuk; Allan R Oseroff; Zachary Grossman; Ravindra K Pandey
Chlorophyll-a analogues conjugated with aminobenzyl-DTPA as potential bifunctional agents for magnetic resonance imaging and photodynamic therapy.
Bioconjugate chemistry 2005;16(1):32-42.
2004: Yihui Chen; Adam Sumlin; Janet Morgan; Amy Gryshuk; Allan R Oseroff; Barbara W Henderson; Thomas J Dougherty; Ravindra K Pandey
Synthesis and photosensitizing efficacy of isomerically pure bacteriopurpurinimides.
Journal of medicinal chemistry 2004;47(20):4814-7.
2004: Guolin Li; Suresh K Pandey; Andrew Graham; Mahabeer P Dobhal; Ricky Mehta; Yihui Chen; Amy Gryshuk; Kate Rittenhouse-Olson; Allan R Oseroff; Ravindra K Pandey
Functionalization of OEP-based benzochlorins to develop carbohydrate-conjugated photosensitizers. Attempt to target beta-galactoside-recognized proteins.
The Journal of organic chemistry 2004;69(1):158-72.
2003: Guolin Li; Andrew Graham; Yihui Chen; Mahabeer P Dobhal; Janet Morgan; Gang Zheng; Andrei Kozyrev; Allan R Oseroff; Thomas J Dougherty; Ravindra K Pandey
Synthesis, comparative photosensitizing efficacy, human serum albumin (site II) binding ability, and intracellular localization characteristics of novel benzobacteriochlorins derived from vic-dihydroxybacteriochlorins.
Journal of medicinal chemistry 2003;46(25):5349-59.
2003: Andrew Graham; Guolin Li; Yihui Chen; Janet Morgan; Allan R Oseroff; Thomas J Dougherty; Ravindra K Pandey
Structure-activity relationship of new octaethylporphyrin-based benzochlorins as photosensitizers for photodynamic therapy.
Photochemistry and photobiology 2003;77(5):561-6.
2002: Yihui Chen; Andrew Graham; William Potter; Janet Morgan; Lurine Vaughan; David A Bellnier; Barbara W Henderson; Allan R Oseroff; Thomas J Dougherty; Ravindra K Pandey
Bacteriopurpurinimides: highly stable and potent photosensitizers for photodynamic therapy.
Journal of medicinal chemistry 2002;45(2):255-8.
2001: Yihui Chen; C J Medforth; K M Smith; James L Alderfer; Thomas J Dougherty; Ravindra K Pandey
Effect of meso-substituents on the osmium tetraoxide reaction and pinacol-pinacolone rearrangement of the corresponding vic-dihydroxyporphyrins.
The Journal of organic chemistry 2001;66(11):3930-9.