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Yi-Guang Chen

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Yi-Guang Chen; Felix Scheuplein; John P Driver; Amanda A Hewes; Peter C Reifsnyder; Edward H Leiter; David V Serreze
Testing the role of P2X7 receptors in the development of type 1 diabetes in nonobese diabetic mice.
John P Driver; David V Serreze; Yi-Guang Chen
Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease.
Felix Scheuplein; Björn Rissiek; John P Driver; Yi-Guang Chen; Friedrich Koch-Nolte; David V Serreze
A recombinant heavy chain antibody approach blocks ART2 mediated deletion of an iNKT cell population that upon activation inhibits autoimmune diabetes.

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All Publications

2011: Yi-Guang Chen; Felix Scheuplein; John P Driver; Amanda A Hewes; Peter C Reifsnyder; Edward H Leiter; David V Serreze
Testing the role of P2X7 receptors in the development of type 1 diabetes in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(7):4278-84.
2011: John P Driver; David V Serreze; Yi-Guang Chen
Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease.
Seminars in immunopathology 2011;33(1):67-87.
2010: Felix Scheuplein; Björn Rissiek; John P Driver; Yi-Guang Chen; Friedrich Koch-Nolte; David V Serreze
A recombinant heavy chain antibody approach blocks ART2 mediated deletion of an iNKT cell population that upon activation inhibits autoimmune diabetes.
Journal of autoimmunity 2010;34(2):145-54.
2010: John P Driver; Felix Scheuplein; Yi-Guang Chen; Alexandra E Grier; S Brian Wilson; David V Serreze
Invariant natural killer T-cell control of type 1 diabetes: a dendritic cell genetic decision of a silver bullet or Russian roulette.
Diabetes 2010;59(2):423-32.
2008: Yi-Guang Chen; Felix Scheuplein; Melissa A Osborne; Shirng-Wern Tsaih; Harold D Chapman; David V Serreze
Idd9/11 genetic locus regulates diabetogenic activity of CD4 T-cells in nonobese diabetic (NOD) mice.
Diabetes 2008;57(12):3273-80.
2007: Yi-Guang Chen; John P Driver; Pablo Alejandro Silveira; David V Serreze
Subcongenic analysis of genetic basis for impaired development of invariant NKT cells in NOD mice.
Immunogenetics 2007;59(9):705-12.
2007: Yi-Guang Chen; Pablo Alejandro Silveira; Melissa A Osborne; Harold D Chapman; David V Serreze
Cellular expression requirements for inhibition of type 1 diabetes by a dominantly protective major histocompatibility complex haplotype.
Diabetes 2007;56(2):424-30.
2006: David V Serreze; Melissa A Osborne; Yi-Guang Chen; Harold D Chapman; Todd Pearson; Michael A Brehm; Dale L Greiner
Partial versus full allogeneic hemopoietic chimerization is a preferential means to inhibit type 1 diabetes as the latter induces generalized immunosuppression.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(10):6675-84.
2006: Yi-Guang Chen; Jing Chen; Melissa A Osborne; Harold D Chapman; Gurdyal S Besra; Steven A Porcelli; Edward H Leiter; S Brian Wilson; David V Serreze
CD38 is required for the peripheral survival of immunotolerogenic CD4+ invariant NK T cells in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(5):2939-47.
2006: Jing Chen; Yi-Guang Chen; Peter C Reifsnyder; William H Schott; Chul-Ho Lee; Melissa Osborne; Felix Scheuplein; Friedrich Haag; Friedrich Koch-Nolte; David V Serreze; Edward H Leiter
Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(8):4590-9.
2006: Chul-Ho Lee; Yi-Guang Chen; Jing Chen; Peter C Reifsnyder; David V Serreze; Michael J Clare-Salzler; Michelle Rodriguez; clive wasserfall; Mark A Atkinson; Edward H Leiter
Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: II. Immunologic analysis.
Diabetes 2006;55(1):171-8.
2005: David V Serreze; Yi-Guang Chen
Of mice and men: use of animal models to identify possible interventions for the prevention of autoimmune type 1 diabetes in humans.
Trends in immunology 2005;26(11):603-7.
2005: Yi-Guang Chen; Caroline-Morgane Choisy-Rossi; Thomas M Holl; Harold D Chapman; Gurdyal S Besra; Steven A Porcelli; Daniel Shaffer; Derry C Roopenian; S Brian Wilson; David V Serreze
Activated NKT cells inhibit autoimmune diabetes through tolerogenic recruitment of dendritic cells to pancreatic lymph nodes.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(3):1196-204.