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Frank Alderuccio

Research Profile

Disorders

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Immune Tolerance

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Publications

TOP 3
H Hosseini; Zeyad Nasa; D Y Oh; Ban-Hock Toh; Hideo Yagita; Frank Alderuccio; S T Chan; X T Chen; J Chan
Non-myeloablative transplantation of bone marrow expressing self-antigen establishes peripheral tolerance and completely prevents autoimmunity in mice.
Zeyad Nasa; Ban-Hock Toh; J Chan; J-Y Chung; Frank Alderuccio
Nonmyeloablative conditioning generates autoantigen-encoding bone marrow that prevents and cures an experimental autoimmune disease.
Frank Alderuccio; Ban-Hock Toh
Tackling autoimmunity with gene therapy.

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2012: H Hosseini; Zeyad Nasa; D Y Oh; Ban-Hock Toh; Hideo Yagita; Frank Alderuccio; S T Chan; X T Chen; J Chan
Non-myeloablative transplantation of bone marrow expressing self-antigen establishes peripheral tolerance and completely prevents autoimmunity in mice.
Gene therapy 2012;19(11):1075-84.
2012: Zeyad Nasa; Ban-Hock Toh; J Chan; J-Y Chung; Frank Alderuccio
Nonmyeloablative conditioning generates autoantigen-encoding bone marrow that prevents and cures an experimental autoimmune disease.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2012;12(8):2062-71.
2012: Frank Alderuccio; Ban-Hock Toh
Tackling autoimmunity with gene therapy.
Chimerism 2012;3(3):1-4.
2012: Christopher Siatskas; Aude Silvain; Guizhi Sun; Ban-Hock Toh; Frank Alderuccio; B Thomas Bäckström; Richard L Boyd; Ashley Emerson-Webber; Natalie Seach; Claude C Bernard
Thymic gene transfer of myelin oligodendrocyte glycoprotein ameliorates the onset but not the progression of autoimmune demyelination.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(7):1349-59.
2012: Ban-Hock Toh; James Chan; Tin Kyaw; Frank Alderuccio
Cutting edge issues in autoimmune gastritis.
Clinical reviews in allergy & immunology 2012;42(3):269-78.
2011: Frank Alderuccio; James Chan; Jieyu Chung; Hyun-Ja Ko; Zeyad Nasa; Ban-Hock Toh
Hematopoietic stem cell gene therapy as a treatment for autoimmune diseases.
Molecular pharmaceutics 2011;8(5):1488-94.
2011: Xiang T Chen; Hamid Hosseini; Daniel Layton; Ban-Hock Toh; Frank Alderuccio; Richard Boyd; Siow T Chan; James Chan
Transplantation of retrovirally transduced bone marrow prevents autoimmune disease in aged mice by peripheral tolerance mechanisms.
Autoimmunity 2011;44(5):384-93.
2011: Hyun-Ja Ko; Jie-Yu Chung; Zeyad Nasa; James Chan; Christopher Siatskas; Ban-Hock Toh; Frank Alderuccio
Targeting MOG expression to dendritic cells delays onset of experimental autoimmune disease.
Autoimmunity 2011;44(3):177-87.
2011: Frank Alderuccio
Stem cell based therapy for autoimmunity.
Current stem cell research & therapy 2011;6(1):1-2.
2011: James Chan; Frank Alderuccio; Ban-Hock Toh
Transplantation of genetically modified haematopoietic stem cells to induce antigen-specific tolerance as a cure for autoimmune diseases.
Current stem cell research & therapy 2011;6(1):44-9.
2010: Hyun-Ja Ko; Sarah A Kinkel; FX Hubert; Zeyad Nasa; James Chan; Christopher Siatskas; Premila Hirubalan; Ban-Hock Toh; Hamish Scott; Frank Alderuccio
Transplantation of autoimmune regulator-encoding bone marrow cells delays the onset of experimental autoimmune encephalomyelitis.
European journal of immunology 2010;40(12):3499-509.
2010: Frank Alderuccio; James Chan; Hyun-Ja Ko; Jie-Yu Chung; Zeyad Nasa; Ban-Hock Toh
A molecular Trojan horse: hijacking the bone marrow to treat autoimmune diseases.
Discovery medicine 2010;9(49):512-8.
2009: Frank Alderuccio; James Chan; David W Scott; Ban-Hock Toh
Gene therapy and bone marrow stem-cell transfer to treat autoimmune disease.
Trends in molecular medicine 2009;15(8):344-51.
2008: James Chan; Ee Jun Ban; Keng Hao Chun; Shunhe Wang; B Thomas Bäckström; Claude C A Bernard; Ban-Hock Toh; Frank Alderuccio
Transplantation of bone marrow transduced to express self-antigen establishes deletional tolerance and permanently remits autoimmune disease.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(11):7571-80.
2008: Frank Alderuccio; James Chan; Ban-Hock Toh
Tweaking the immune system: gene therapy-assisted autologous haematopoietic stem cell transplantation as a treatment for autoimmune disease.
Autoimmunity 2008;41(8):679-85.
2008: Judith Field; Frank Alderuccio; Paul Hertzog; Ban-Hock Toh
GM-CSF-induced autoimmune gastritis in interferon alpha receptor deficient mice.
Journal of autoimmunity 2008;31(3):274-80.
2008: James Chan; Ee Jun Ban; Keng Hao Chun; Shunhe Wang; Jonathan McQualter; Claude Bernard; Ban-Hock Toh; Frank Alderuccio
Methylprednisolone induces reversible clinical and pathological remission and loss of lymphocyte reactivity to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis.
Autoimmunity 2008;41(5):405-13.
2006: James Chan; Warren Clements; Judith Field; Zeyad Nasa; Peter Lock; Felicia Yap; Ban-Hock Toh; Frank Alderuccio
Transplantation of bone marrow genetically engineered to express proinsulin II protects against autoimmune insulitis in NOD mice.
The journal of gene medicine 2006;8(11):1281-90.
2006: Frank Alderuccio; Christopher Siatskas; James Chan; Judith Field; Kim Murphy; Zeyad Nasa; Ban-Hock Toh
Haematopoietic stem cell gene therapy to treat autoimmune disease.
Current stem cell research & therapy 2006;1(3):279-87.
2006: Mark Biondo; Judith Field; Ban-Hock Toh; Frank Alderuccio
Prednisolone promotes remission and gastric mucosal regeneration in experimental autoimmune gastritis.
The Journal of pathology 2006;209(3):384-91.
2006: Christopher Siatskas; James Chan; Judith Field; Kim Murphy; Zeyad Nasa; Ban-Hock Toh; Frank Alderuccio
Gene therapy strategies towards immune tolerance to treat the autoimmune diseases.
Current gene therapy 2006;6(1):45-58.
2005: Frank Alderuccio; Kim Murphy; Mark Biondo; Judith Field; Ban-Hock Toh
Reversing the autoimmune condition: experience with experimental autoimmune gastritis.
International reviews of immunology 2005;24(1-2):135-55.
2005: Aiden C J Marshall; Frank Alderuccio; Kim Murphy; Ban-Hock Toh
Mechanisms of gastric mucosal cell loss in autoimmune gastritis.
International reviews of immunology 2005;24(1-2):123-34.
2005: Judith Field; Mark Biondo; Kim Murphy; Frank Alderuccio; Ban-Hock Toh
Experimental autoimmune gastritis: mouse models of human organ-specific autoimmune disease.
International reviews of immunology 2005;24(1-2):93-110.
2004: Frank Alderuccio; Ban-Hock Toh
Induction of tolerance to self-antigens using genetically modified bone marrow cells.
Expert opinion on biological therapy 2004;4(7):1007-14.
2004: Ban-Hock Toh; Frank Alderuccio
Pernicious anaemia.
Autoimmunity 2004;37(4):357-61.
2004: Aiden C J Marshall; Ban-Hock Toh; Frank Alderuccio
Tumor necrosis factor alpha is not implicated in the genesis of experimental autoimmune gastritis.
Journal of autoimmunity 2004;22(1):1-11.
2003: Judith Field; Aiden C J Marshall; Paul J Hertzog; Timothy Wells; Frank Alderuccio; Ban-Hock Toh
Chemokine receptor CCR5 is not required for development of experimental autoimmune gastritis.
Clinical immunology (Orlando, Fla.) 2003;109(2):238-47.
2003: Frank Alderuccio; Kim Murphy; Ban-Hock Toh
Stem cells engineered to express self-antigen to treat autoimmunity.
Trends in immunology 2003;24(4):176-80.
2003: Kim Murphy; Mark Biondo; Ban-Hock Toh; Frank Alderuccio
Tolerance established in autoimmune disease by mating or bone marrow transplantation that target autoantigen to thymus.
International immunology 2003;15(2):269-77.
2002: Aiden C J Marshall; Frank Alderuccio; Ban-Hock Toh
Fas/CD95 is required for gastric mucosal damage in autoimmune gastritis.
Gastroenterology 2002;123(3):780-9.
2002: Deanne L V Greenwood; Veronika M Gitlits; Frank Alderuccio; John W Sentry; Ban-Hock Toh
Autoantibodies in neuropsychiatric lupus.
Autoimmunity 2002;35(2):79-86.
2002: Frank Alderuccio; Mark Biondo; Ban-Hock Toh
Organ-specific autoimmunity in granulocyte macrophage-colony stimulating factor (GM-CSF) deficient mice.
Autoimmunity 2002;35(1):67-73.
2002: Frank Alderuccio; John W Sentry; Aiden C J Marshall; Mark Biondo; Ban-Hock Toh
Animal models of human disease: experimental autoimmune gastritis--a model for autoimmune gastritis and pernicious anemia.
Clinical immunology (Orlando, Fla.) 2002;102(1):48-58.
2001: Mark Biondo; Zeyad Nasa; A Marshall; Ban-Hock Toh; Frank Alderuccio
Local transgenic expression of granulocyte macrophage-colony stimulating factor initiates autoimmunity.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(3):2090-9.
2000: Frank Alderuccio; Ban-Hock Toh
Immunopathology of autoimmune gastritis: lessons from mouse models.
Histology and histopathology 2000;15(3):869-79.
2000: Ban-Hock Toh; John W Sentry; Frank Alderuccio
The causative H+/K+ ATPase antigen in the pathogenesis of autoimmune gastritis.
Immunology today 2000;21(7):348-54.
2000: Frank Alderuccio; V Cataldo; Ian R van Driel; Paul A Gleeson; Ban-Hock Toh
Tolerance and autoimmunity to a gastritogenic peptide in TCR transgenic mice.
International immunology 2000;12(3):343-52.
2000: Harini D de Silva; Frank Alderuccio; Ban-Hock Toh; Ian R van Driel; P A Gleeso
Defining T cell receptors which recognise the immunodominant epitope of the gastric autoantigen, the H/K ATPase beta-subunit.
Autoimmunity 2000;33(1):1-14.
1998: Frank Alderuccio; Ban-Hock Toh
Spontaneous autoimmune gastritis in C3H/He mice: a new mouse model for gastric autoimmunity.
The American journal of pathology 1998;153(4):1311-8.
1997: Frank Alderuccio; Paul A Gleeson; Stuart P Berzins; M Martin; Ian R van Driel; Ban-Hock Toh
Expression of the gastric H/K-ATPase alpha-subunit in the thymus may explain the dominant role of the beta-subunit in the pathogenesis of autoimmune gastritis.
Autoimmunity 1997;25(3):167-75.
1996: T M Martinelli; Ian R van Driel; Frank Alderuccio; Paul A Gleeson; Ban-Hock Toh
Analysis of mononuclear cell infiltrate and cytokine production in murine autoimmune gastritis.
Gastroenterology 1996;110(6):1791-802.
1995: S P Barrett; Ian R van Driel; S S Tan; Frank Alderuccio; Ban-Hock Toh; Paul A Gleeson
Expression of a gastric autoantigen in pancreatic islets results in non-destructive insulitis after neonatal thymectomy.
European journal of immunology 1995;25(9):2686-94.
1995: Frank Alderuccio; Ban-Hock Toh; Paul A Gleeson; Ian R van Driel
A novel method for isolating mononuclear cells from the stomachs of mice with experimental autoimmune gastritis.
Autoimmunity 1995;21(3):215-21.
1995: S P Barrett; Ban-Hock Toh; Frank Alderuccio; Ian R van Driel; Paul A Gleeson
Organ-specific autoimmunity induced by adult thymectomy and cyclophosphamide-induced lymphopenia.
European journal of immunology 1995;25(1):238-44.
1994: J P Yeo; Frank Alderuccio; Ban-Hock Toh
A new chromosomal protein essential for mitotic spindle assembly.
Nature 1994;367(6460):288-91.
1993: Frank Alderuccio; Ban-Hock Toh; S S Tan; Paul A Gleeson; Ian R van Driel
An autoimmune disease with multiple molecular targets abrogated by the transgenic expression of a single autoantigen in the thymus.
The Journal of experimental medicine 1993;178(2):419-26.
1993: judy callaghan; M A Khan; Frank Alderuccio; Ian R van Driel; Paul A Gleeson; Ban-Hock Toh
Alpha and beta subunits of the gastric H+/K(+)-ATPase are concordantly targeted by parietal cell autoantibodies associated with autoimmune gastritis.
Autoimmunity 1993;16(4):289-95.
1989: Frank Alderuccio; D Witherden; Ban-Hock Toh; A Barnett
Autoantibody to gp50, a glycoprotein shared in common between fibroblasts and lymphocytes, in progressive systemic sclerosis.
Clinical and experimental immunology 1989;78(1):26-30.
1989: Frank Alderuccio; Jennifer M Rolland; G C Toner; M A Schwarz; James McCluskey; Ban-Hock Toh
Autoantibodies to neurons and to the cytoskeleton in small cell carcinoma with paraneoplastic sensory neuropathy.
Autoimmunity 1989;5(1-2):115-23.
1988: F T Mu; Frank Alderuccio; Ban-Hock Toh; M Eric Gershwin; Ross Coppel; I R Mackay
Murine monoclonal antibody to mitochondria reacts with the 72 kD antigen of primary biliary cirrhosis.
Clinical and experimental immunology 1988;71(1):100-6.
1986: Frank Alderuccio; Ban-Hock Toh; A J Barnett; J S Pedersen
Identification and characterization of mitochondria autoantigens in progressive systemic sclerosis: identity with the 72,000 dalton autoantigen in primary biliary cirrhosis.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(6):1855-9.
1986: Frank Alderuccio; A J Barnett; J H Campbell; J S Pedersen; Ban-Hock Toh
Scl-95/100: doublet of endothelial marker autoantigens in progressive systemic sclerosis.
Clinical and experimental immunology 1986;64(1):94-100.
1985: J R Underwood; F T Mu; Frank Alderuccio; W Williams; H J De Aizpurua; J S Pedersen; P J Chalmers; B H Toh
Monoclonal antibody to myosin derived from mice immunized with gastric mucosal cells.
Journal of clinical & laboratory immunology 1985;17(3):107-10.
1984: S J Lolait; J R Underwood; F T Mu; Frank Alderuccio; C A Dow; J S Pedersen; P J Chalmers; Ban-Hock Toh
Vimentin intermediate filaments in cultures of human meningiomas.
Neuropathology and applied neurobiology 1984;10(5):321-31.