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Zhong Chen

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Hai Lu; Liesl Nottingham; Rose-Anne Romano; Satrajit Sinha; Clint T Allen; Zhong Chen; Jonah Cohen; Praveen Duggal; Kathryn E King; Wendy C Weinberg; Bin Yan; Xinping Yang; Carter Van Waes
TNF-α promotes c-REL/ΔNp63α interaction and TAp73 dissociation from key genes that mediate growth arrest and apoptosis in head and neck cancer.
Xinping Yang; Clint Allen; Yansong Bian; Ryan Chuang; Praveen Duggal; Reza Ehsanian; Jay Friedman; Hai Lu; Rose-Anne Romano; Han Si; Satrajit Sinha; Carter Van Waes; Bin Yan; Zhong Chen
ΔNp63 versatilely regulates a Broad NF-κB gene program and promotes squamous epithelial proliferation, migration, and inflammation.
Christian Freudlsperger; Jeffrey R Burnett; Jay A Friedman; Vishnu R Kannabiran; Zhong Chen; Carter Van Waes
EGFR-PI3K-AKT-mTOR signaling in head and neck squamous cell carcinomas: attractive targets for molecular-oriented therapy.

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2011: Hai Lu; Liesl Nottingham; Rose-Anne Romano; Satrajit Sinha; Clint T Allen; Zhong Chen; Jonah Cohen; Praveen Duggal; Kathryn E King; Wendy C Weinberg; Bin Yan; Xinping Yang; Carter Van Waes
TNF-α promotes c-REL/ΔNp63α interaction and TAp73 dissociation from key genes that mediate growth arrest and apoptosis in head and neck cancer.
Cancer research 2011;71(21):6867-77.
2011: Xinping Yang; Clint Allen; Yansong Bian; Ryan Chuang; Praveen Duggal; Reza Ehsanian; Jay Friedman; Hai Lu; Rose-Anne Romano; Han Si; Satrajit Sinha; Carter Van Waes; Bin Yan; Zhong Chen
ΔNp63 versatilely regulates a Broad NF-κB gene program and promotes squamous epithelial proliferation, migration, and inflammation.
Cancer research 2011;71(10):3688-700.
2011: Christian Freudlsperger; Jeffrey R Burnett; Jay A Friedman; Vishnu R Kannabiran; Zhong Chen; Carter Van Waes
EGFR-PI3K-AKT-mTOR signaling in head and neck squamous cell carcinomas: attractive targets for molecular-oriented therapy.
Expert opinion on therapeutic targets 2011;15(1):63-74.
2010: R Ehsanian; M Brown; H Lu; Xin Ping Yang; A Pattatheyil; Bin Yan; Priya Duggal; R Chuang; J Doondeea; S Feller; M Sudol; Zhong Chen; Carter Van Waes
YAP dysregulation by phosphorylation or ΔNp63-mediated gene repression promotes proliferation, survival and migration in head and neck cancer subsets.
Oncogene 2010;29(46):6160-71.
2010: Carter Van Waes; Clint T Allen; Deborah Citrin; David Gius; A Dimetrios Colevas; Nancy A Harold; Susan F Rudy; Liesl Nottingham; Christine Muir; Zhong Chen; Anurag K Singh; Janet Dancey; John C Morris
Molecular and clinical responses in a pilot study of gefitinib with paclitaxel and radiation in locally advanced head-and-neck cancer.
International journal of radiation oncology, biology, physics 2010;77(2):447-54.
2010: Matthew S Brown; Oumou T Diallo; Michael Hu; Reza Ehsanian; Xinping Yang; Pattatheyil Arun; Hai Lu; Vicci Korman; Gretchen Unger; Khalil Ahmed; Carter Van Waes; Zhong Chen
CK2 modulation of NF-kappaB, TP53, and the malignant phenotype in head and neck cancer by anti-CK2 oligonucleotides in vitro or in vivo via sub-50-nm nanocapsules.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(8):2295-307.
2009: Pattatheyil Arun; Matthew S Brown; Reza Ehsanian; Zhong Chen; Carter Van Waes
Nuclear NF-kappaB p65 phosphorylation at serine 276 by protein kinase A contributes to the malignant phenotype of head and neck cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(19):5974-84.
2009: Francisco G Pernas; Clint T Allen; Mary E Winters; Bin Yan; Jay Friedman; Bhavana Dabir; Kunal Saigal; Gerhard S Mundinger; Xiaojiang Xu; John C Morris; Katherine R Calvo; Carter Van Waes; Zhong Chen
Proteomic signatures of epidermal growth factor receptor and survival signal pathways correspond to gefitinib sensitivity in head and neck cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(7):2361-72.
2008: Myong-Hee Sung; Lorena Bagain; Zhong Chen; Tatiana Karpova; Xinping Yang; Christopher Silvin; ty voss; James G McNally; Carter Van Waes; Gordon L Hager
Dynamic effect of bortezomib on nuclear factor-kappaB activity and gene expression in tumor cells.
Molecular pharmacology 2008;74(5):1215-22.
2008: Matthew Brown; Jonah Cohen; Pattatheyil Arun; Zhong Chen; Carter Van Waes
NF-kappaB in carcinoma therapy and prevention.
Expert opinion on therapeutic targets 2008;12(9):1109-22.
2008: Jason A Poff; Clint T Allen; Bryan Traughber; Aric Colunga; Jianwu Xie; Zhong Chen; Bradford J Wood; Carter Van Waes; King Li; Victor Frenkel
Pulsed high-intensity focused ultrasound enhances apoptosis and growth inhibition of squamous cell carcinoma xenografts with proteasome inhibitor bortezomib.
Radiology 2008;248(2):485-91.
2008: Zhong Chen; Justin L Ricker; Pramit S Malhotra; Liesl Nottingham; Lorena Bagain; Tin-Lap Lee; Ning T Yeh; Carter Van Waes
Differential bortezomib sensitivity in head and neck cancer lines corresponds to proteasome, nuclear factor-kappaB and activator protein-1 related mechanisms.
Molecular cancer therapeutics 2008;7(7):1949-60.
2008: Clint Allen; Kunal Saigal; Liesl Nottingham; Pattatheyil Arun; Zhong Chen; Carter Van Waes
Bortezomib-induced apoptosis with limited clinical response is accompanied by inhibition of canonical but not alternative nuclear factor-{kappa}B subunits in head and neck cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(13):4175-85.
2008: Tin-Lap Lee; Jason Yeh; Jay Friedman; Bin Yan; Xinping Yang; Ning T Yeh; Carter Van Waes; Zhong Chen
A signal network involving coactivated NF-kappaB and STAT3 and altered p53 modulates BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas.
International journal of cancer. Journal international du cancer 2008;122(9):1987-98.
2008: Bin Yan; Guang Chen; Kunal Saigal; Xinping Yang; Shane T Jensen; Carter Van Waes; Christian J Stoeckert; Zhong Chen
Systems biology-defined NF-kappaB regulons, interacting signal pathways and networks are implicated in the malignant phenotype of head and neck cancer cell lines differing in p53 status.
Genome biology 2008;9(3):R53.
2007: Jay Friedman; Liesl Nottingham; Praveen Duggal; Francisco G Pernas; Bin Yan; Xin Ping Yang; Zhong Chen; Carter Van Waes
Deficient TP53 expression, function, and cisplatin sensitivity are restored by quinacrine in head and neck cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(22 Pt 1):6568-78.
2007: Tin-Lap Lee; Xin Ping Yang; Bin Yan; Jay Friedman; Praveen Duggal; Lorena Bagain; Gang Dong; Ning T Yeh; Jie Wang; Jian Zhou; Abdel G Elkahloun; Carter Van Waes; Zhong Chen
A novel nuclear factor-kappaB gene signature is differentially expressed in head and neck squamous cell carcinomas in association with TP53 status.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(19):5680-91.
2007: Clint T Allen; Justin L Ricker; Zhong Chen; Carter Van Waes
Role of activated nuclear factor-kappaB in the pathogenesis and therapy of squamous cell carcinoma of the head and neck.
Head & neck 2007;29(10):959-71.
2007: Clint Allen; Sonia A Duffy; Theodoros N Teknos; Mozaffarul Islam; Zhong Chen; Paul S Albert; Gregory T Wolf; Carter Van Waes
Nuclear factor-kappaB-related serum factors as longitudinal biomarkers of response and survival in advanced oropharyngeal carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(11):3182-90.
2007: Eric R Snyder; Justin L Ricker; Zhong Chen; Carter Van Waes
Variation in cisplatinum sensitivity is not associated with Fanconi Anemia/BRCA pathway inactivation in head and neck squamous cell carcinoma cell lines.
Cancer letters 2007;245(1-2):75-80.
2007: Zhong Chen; Tin-Lap Lee; Xin-Ping Yang; Gang Dong; Amy Loercher; Carter Van Waes
cDNA microarray and bioinformatic analysis of nuclear factor-kappaB related genes in squamous cell carcinoma.
Methods in molecular biology (Clifton, N.J.) 2007;383():81-99.
2007: Bin Yan; Xinping Yang; Tin-Lap Lee; Jay Friedman; Jun Tang; Carter Van Waes; Zhong Chen
Genome-wide identification of novel expression signatures reveal distinct patterns and prevalence of binding motifs for p53, nuclear factor-kappaB and other signal transcription factors in head and neck squamous cell carcinoma.
Genome biology 2007;8(5):R78.
2007: Jianming Duan; Jay Friedman; Liesl Nottingham; Zhong Chen; Gulshan Ara; Carter Van Waes
Nuclear factor-kappaB p65 small interfering RNA or proteasome inhibitor bortezomib sensitizes head and neck squamous cell carcinomas to classic histone deacetylase inhibitors and novel histone deacetylase inhibitor PXD101.
Molecular cancer therapeutics 2007;6(1):37-50.
2006: Tin-Lap Lee; Jason Yeh; Carter Van Waes; Zhong Chen
Epigenetic modification of SOCS-1 differentially regulates STAT3 activation in response to interleukin-6 receptor and epidermal growth factor receptor signaling through JAK and/or MEK in head and neck squamous cell carcinomas.
Molecular cancer therapeutics 2006;5(1):8-19.
2005: Carter Van Waes; Angela A Chang; Peter F Lebowitz; Colleen H Druzgal; Zhong Chen; Yusri A Elsayed; John B Sunwoo; Susan F Rudy; John C Morris; James B Mitchell; Kevin A Camphausen; David Gius; Julian Adams; Edward A Sausville; BA Conley
Inhibition of nuclear factor-kappaB and target genes during combined therapy with proteasome inhibitor bortezomib and reirradiation in patients with recurrent head-and-neck squamous cell carcinoma.
International journal of radiation oncology, biology, physics 2005;63(5):1400-12.
2005: Colleen H Druzgal; Zhong Chen; Ning T Yeh; Giovana R Thomas; Frank G Ondrey; Dianne C Duffey; Ronald J Vilela; Kevin Ende; Linda McCullagh; Susan F Rudy; Christine Muir; Laurie L Herscher; John C Morris; Paul S Albert; Carter Van Waes
A pilot study of longitudinal serum cytokine and angiogenesis factor levels as markers of therapeutic response and survival in patients with head and neck squamous cell carcinoma.
Head & neck 2005;27(9):771-84.
2005: Brian Worden; Xin Ping Yang; Tin-Lap Lee; Lorena Bagain; Ning T Yeh; Joshua G Cohen; Carter Van Waes; Zhong Chen
Hepatocyte growth factor/scatter factor differentially regulates expression of proangiogenic factors through Egr-1 in head and neck squamous cell carcinoma.
Cancer research 2005;65(16):7071-80.
2004: Justin L Ricker; Zhong Chen; Xin Ping Yang; Victor S Pribluda; Glenn M Swartz; Carter Van Waes
2-methoxyestradiol inhibits hypoxia-inducible factor 1alpha, tumor growth, and angiogenesis and augments paclitaxel efficacy in head and neck squamous cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(24):8665-73.
2004: Amy Loercher; Tin-Lap Lee; Justin L Ricker; April Howard; Joel Geoghegen; Zhong Chen; John B Sunwoo; Raquel Sitcheran; Eric Y Chuang; James B Mitchell; Albert S Baldwin; Carter Van Waes
Nuclear factor-kappaB is an important modulator of the altered gene expression profile and malignant phenotype in squamous cell carcinoma.
Cancer research 2004;64(18):6511-23.
2004: Gang Dong; Tin-Lap Lee; Ning T Yeh; Joel Geoghegan; Carter Van Waes; Zhong Chen
Metastatic squamous cell carcinoma cells that overexpress c-Met exhibit enhanced angiogenesis factor expression, scattering and metastasis in response to hepatocyte growth factor.
Oncogene 2004;23(37):6199-208.
2002: Erik S Kass; John W Greiner; Judith A Kantor; Kwong-Yok Tsang; Fiorella Guadagni; Zhong Chen; Bradly Clark; Roberto De Pascalis; Jeffrey Schlom; Carter Van Waes
Carcinoembryonic antigen as a target for specific antitumor immunotherapy of head and neck cancer.
Cancer research 2002;62(17):5049-57.
2002: Caren C Bancroft; Zhong Chen; Jason Yeh; John B Sunwoo; Ning T Yeh; Sadhana Jackson; Chad Jackson; Carter Van Waes
Effects of pharmacologic antagonists of epidermal growth factor receptor, PI3K and MEK signal kinases on NF-kappaB and AP-1 activation and IL-8 and VEGF expression in human head and neck squamous cell carcinoma lines.
International journal of cancer. Journal international du cancer 2002;99(4):538-48.
2001: E Loukinova; Zhong Chen; Carter Van Waes; Gang Dong
Expression of proangiogenic chemokine Gro 1 in low and high metastatic variants of Pam murine squamous cell carcinoma is differentially regulated by IL-1alpha, EGF and TGF-beta1 through NF-kappaB dependent and independent mechanisms.
International journal of cancer. Journal international du cancer 2001;94(5):637-44.
2001: Gang Dong; Zhong Chen; Z Y Li; Ning T Yeh; Caren C Bancroft; Carter Van Waes
Hepatocyte growth factor/scatter factor-induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma.
Cancer research 2001;61(15):5911-8.
2001: Gang Dong; E Loukinova; Zhong Chen; L Gangi; T I Chanturita; Edison Liu; Carter Van Waes
Molecular profiling of transformed and metastatic murine squamous carcinoma cells by differential display and cDNA microarray reveals altered expression of multiple genes related to growth, apoptosis, angiogenesis, and the NF-kappaB signal pathway.
Cancer research 2001;61(12):4797-808.
2001: Jeffrey S Wolf; Zhong Chen; Gang Dong; John B Sunwoo; Caren C Bancroft; D E Capo; Ning T Yeh; N Mukaida; Carter Van Waes
IL (interleukin)-1alpha promotes nuclear factor-kappaB and AP-1-induced IL-8 expression, cell survival, and proliferation in head and neck squamous cell carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(6):1812-20.
2001: John B Sunwoo; Zhong Chen; Gang Dong; Ning T Yeh; CV Crowl-Bancroft; Edward A Sausville; J Adams; P Elliott; Carter Van Waes
Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(5):1419-28.
2001: Caren C Bancroft; Zhong Chen; Gang Dong; John B Sunwoo; Ning T Yeh; C Park; Carter Van Waes
Coexpression of proangiogenic factors IL-8 and VEGF by human head and neck squamous cell carcinoma involves coactivation by MEK-MAPK and IKK-NF-kappaB signal pathways.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(2):435-42.
2000: T Kato; Dianne C Duffey; Frank G Ondrey; Gang Dong; Zhong Chen; John A Cook; James B Mitchell; Carter Van Waes
Cisplatin and radiation sensitivity in human head and neck squamous carcinomas are independently modulated by glutathione and transcription factor NF-kappaB.
Head & neck 2000;22(8):748-59.
2000: Dianne C Duffey; CV Crowl-Bancroft; Zhong Chen; Frank G Ondrey; M Nejad-Sattari; Gang Dong; Carter Van Waes
Inhibition of transcription factor nuclear factor-kappaB by a mutant inhibitor-kappaBalpha attenuates resistance of human head and neck squamous cell carcinoma to TNF-alpha caspase-mediated cell death.
British journal of cancer 2000;83(10):1367-74.
2000: SH Hong; Frank G Ondrey; I M Avis; Zhong Chen; E Loukinova; Paul F Cavanaugh; Carter Van Waes; James L Mulshine
Cyclooxygenase regulates human oropharyngeal carcinomas via the proinflammatory cytokine IL-6: a general role for inflammation?
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(11):1499-507.
2000: E Loukinova; Gang Dong; I Enamorado-Ayalya; Giovana R Thomas; Zhong Chen; H Schreiber; Carter Van Waes
Growth regulated oncogene-alpha expression by murine squamous cell carcinoma promotes tumor growth, metastasis, leukocyte infiltration and angiogenesis by a host CXC receptor-2 dependent mechanism.
Oncogene 2000;19(31):3477-86.
2000: Giovana R Thomas; Zhong Chen; I Enamorado; Caren C Bancroft; Carter Van Waes
IL-12- and IL-2-induced tumor regression in a new murine model of oral squamous-cell carcinoma is promoted by expression of the CD80 co-stimulatory molecule and interferon-gamma.
International journal of cancer. Journal international du cancer 2000;86(3):368-74.
1999: Frank G Ondrey; Gang Dong; John B Sunwoo; Zhong Chen; Jeffrey S Wolf; CV Crowl-Bancroft; N Mukaida; Carter Van Waes
Constitutive activation of transcription factors NF-(kappa)B, AP-1, and NF-IL6 in human head and neck squamous cell carcinoma cell lines that express pro-inflammatory and pro-angiogenic cytokines.
Molecular carcinogenesis 1999;26(2):119-29.
1999: Giovana R Thomas; Zhong Chen; M N Oechsli; Fred Hendler; Carter Van Waes
Decreased expression of CD80 is a marker for increased tumorigenicity in a new murine model of oral squamous-cell carcinoma.
International journal of cancer. Journal international du cancer 1999;82(3):377-84.
1999: Gang Dong; Zhong Chen; T Kato; Carter Van Waes
The host environment promotes the constitutive activation of nuclear factor-kappaB and proinflammatory cytokine expression during metastatic tumor progression of murine squamous cell carcinoma.
Cancer research 1999;59(14):3495-504.
1999: Dianne C Duffey; Zhong Chen; Gang Dong; Frank G Ondrey; Jeffrey S Wolf; K Brown; U Siebenlist; Carter Van Waes
Expression of a dominant-negative mutant inhibitor-kappaBalpha of nuclear factor-kappaB in human head and neck squamous cell carcinoma inhibits survival, proinflammatory cytokine expression, and tumor growth in vivo.
Cancer research 1999;59(14):3468-74.
1999: Zhong Chen; P S Malhotra; Giovana R Thomas; Frank G Ondrey; Dianne C Duffey; C W Smith; I Enamorado; Ning T Yeh; Glenn S Kroog; Susan F Rudy; Linda McCullagh; S Mousa; M Quezado; Laurie L Herscher; Carter Van Waes
Expression of proinflammatory and proangiogenic cytokines in patients with head and neck cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(6):1369-79.
1998: C W Smith; Zhong Chen; Gang Dong; E Loukinova; M Y Pegram; L Nicholas-Figueroa; Carter Van Waes
The host environment promotes the development of primary and metastatic squamous cell carcinomas that constitutively express proinflammatory cytokines IL-1alpha, IL-6, GM-CSF, and KC.
Clinical & experimental metastasis 1998;16(7):655-64.
1998: T Kato; Gang Dong; E Loukinova; Zhong Chen; Carter Van Waes
Differential expression of the murine Ly-6A/E antigen homolog of human squamous cell carcinoma antigen E48 during malignant transformation and tumor progression of squamous cell carcinoma line Pam 212.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 1998;119(4):408-11.
1998: Zhong Chen; I Colon; N Ortiz; M Callister; Gang Dong; M Y Pegram; O Arosarena; Scott E Strome; J C Nicholson; Carter Van Waes
Effects of interleukin-1alpha, interleukin-1 receptor antagonist, and neutralizing antibody on proinflammatory cytokine expression by human squamous cell carcinoma lines.
Cancer research 1998;58(16):3668-76.
1997: Zhong Chen; C W Smith; D Kiel; Carter Van Waes
Metastatic variants derived following in vivo tumor progression of an in vitro transformed squamous cell carcinoma line acquire a differential growth advantage requiring tumor-host interaction.
Clinical & experimental metastasis 1997;15(5):527-37.
1995: Carter Van Waes; D M Surh; Zhong Chen; M Kirby; J S Rhim; R Brager; Roy B Sessions; J Poore; Gregory T Wolf; Thomas Carey
Increase in suprabasilar integrin adhesion molecule expression in human epidermal neoplasms accompanies increased proliferation occurring with immortalization and tumor progression.
Cancer research 1995;55(22):5434-44.