FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Heping Cheng

Research Profile

Chemicals & Drugs

Living Beings

Anatomy

Physiology

Disorders

Myocardial Contraction

Procedures

Concepts & Ideas

Membrane Potentials

Co-author Network

Publications

TOP 3
Huiliang Zhang; Ming Zheng; Ana M Gomez; Xianhua Wang; Yuan Yan; Heping Cheng
ROS regulation of microdomain Ca2+ signalling at the dyads.
Wei Zhao; Yangde Chen; Heping Cheng; Weigang Fang; Ting Guo; Haibo Han; Kemin Jin; Na Lin; Fengmin Lu; Limin Wang; Yu Wang; Baocai Xing; Zhiqian Zhang
1B50-1, a mAb raised against recurrent tumor cells, targets liver tumor-initiating cells by binding to the calcium channel α2δ1 subunit.
Xiaohu Huang; Shuangxi Ji; Lei Sun; Xianhua Wang; Yanru Wang; Jiejia Xu; Jue Zhang; Wanrui Zhang; Ting Zhao; Ming Zheng; Clara Franzini-Armstrong; Heping Cheng
Kissing and nanotunneling mediate intermitochondrial communication in the heart.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Heping Cheng (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Huiliang Zhang; Ming Zheng; Ana M Gomez; Xianhua Wang; Yuan Yan; Heping Cheng
ROS regulation of microdomain Ca2+ signalling at the dyads.
Cardiovascular research 2013;98(2):248-58.
2013: Wei Zhao; Yangde Chen; Heping Cheng; Weigang Fang; Ting Guo; Haibo Han; Kemin Jin; Na Lin; Fengmin Lu; Limin Wang; Yu Wang; Baocai Xing; Zhiqian Zhang
1B50-1, a mAb raised against recurrent tumor cells, targets liver tumor-initiating cells by binding to the calcium channel α2δ1 subunit.
Cancer cell 2013;23(4):541-56.
2013: Xiaohu Huang; Shuangxi Ji; Lei Sun; Xianhua Wang; Yanru Wang; Jiejia Xu; Jue Zhang; Wanrui Zhang; Ting Zhao; Ming Zheng; Clara Franzini-Armstrong; Heping Cheng
Kissing and nanotunneling mediate intermitochondrial communication in the heart.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(8):2846-51.
2013: Tingting Hou; Keping Hu; Zhanglong Huang; Chongshu Jian; Xianhua Wang; Jiejia Xu; Tao Ye; Xing Zhang; Ming Zheng; Feng Gao; Heping Cheng
Synergistic triggering of superoxide flashes by mitochondrial Ca2+ uniport and basal reactive oxygen species elevation.
The Journal of biological chemistry 2013;288(7):4602-12.
2012: Yan Hou; Mark P Mattson; Xin Ouyang; Ruiqian Wan; Heping Cheng; Aiwu Cheng
Mitochondrial superoxide production negatively regulates neural progenitor proliferation and cerebral cortical development.
Stem cells (Dayton, Ohio) 2012;30(11):2535-47.
2012: Ting Zhao; Yungang Zhao; Ju Chen; Quan Chen; Heping Cheng; Hongqiang Cheng; Liang Han; Xiaohu Huang; Xianhua Wang; Ruiping Xiao; Ming Zheng
Central role of mitofusin 2 in autophagosome-lysosome fusion in cardiomyocytes.
The Journal of biological chemistry 2012;287(28):23615-25.
2012: Noah Weisleder; Rui-Ping Xiao; Rosalie Yan; Yan Zhang; Xiaoli Zhao; Hua Zhu; Matthew Sterling; Hiroshi Takeshima; Miyuki Takeshima; Norio Takizawa; Tao Tan; Xianhua Wang; Chuanxi Cai; Chunmei Cao; Pin-Jung Chen; Heping Cheng; Christopher Ferrante; Moonsun Hwang; Peihui Lin; Jianjie Ma
Recombinant MG53 protein modulates therapeutic cell membrane repair in treatment of muscular dystrophy.
Science translational medicine 2012;4(139):139ra85.
2012: Xianhua Wang; Yuefan Wang; Jiejia Xu; Zhen Yang; Wanrui Zhang; Xing Zhang; Ming Zheng; Yi Ding; Tingting Hou; Zhanglong Huang; Chongshu Jian; Meng Ouyang; Wei Shang; Heping Cheng
Superoxide flashes: elemental events of mitochondrial ROS signaling in the heart.
Journal of molecular and cellular cardiology 2012;52(5):940-8.
2012: Chaoliang Wei; Ming Zheng; Xianhua Wang; Heping Cheng
Calcium gradients underlying cell migration.
Current opinion in cell biology 2012;24(2):254-61.
2012: Kaitao Li; Jie Liu; Wenchang Tan; Wang Wang; Xianhua Wang; Wenjun Xie; Wanrui Zhang; Ming Zheng; Huaqiang Fang; Heping Cheng
Superoxide flashes reveal novel properties of mitochondrial reactive oxygen species excitability in cardiomyocytes.
Biophysical journal 2012;102(5):1011-21.
2012: Didier Brochet; Heping Cheng; Dongmei Yang; W Jonathan Lederer
Elementary calcium release events from the sarcoplasmic reticulum in the heart.
Advances in experimental medicine and biology 2012;740():499-509.
2011: Zhanglong Huang; Heping Cheng; Robert T Dirksen; Huaqiang Fang; Guohua Gong; Wang Wang; Xianhua Wang; Jiejia Xu; Wanrui Zhang; Ming Zheng; Shey-Shing Sheu
Response to "A critical evaluation of cpYFP as a probe for superoxide".
Free radical biology & medicine 2011;51(10):1937-40.
2011: Peidong Han; Demetrios A Arvanitis; Wenfeng Cai; Shan Chen; Heping Cheng; Chi Keung Lam; Vivek P Singh; Yanru Wang; Huiliang Zhang; Rongli Zhang; Evangelia G Kranias
Catecholaminergic-induced arrhythmias in failing cardiomyocytes associated with human HRCS96A variant overexpression.
American journal of physiology. Heart and circulatory physiology 2011;301(4):H1588-95.
2011: Huaqiang Fang; Feng Gao; Jing-Chao Li; Kaitao Li; Jianjie Ma; Kunfu Ouyang; Shujiang Shang; Wei Shang; Xiao-Li Tian; Shi-Qiang Wang; Wang Wang; Xianhua Wang; Noah Weisleder; Yao Xiao; Jiejia Xu; Wanrui Zhang; Xiuqin Zhang; Xing Zhang; Ming Zheng; Jingsong Zhou; Ju Chen; Min Chen; Yi Ding; Heping Cheng
Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals.
Cell research 2011;21(9):1295-304.
2011: Qiang Zhou; Weizhong Zhu; Thomas G Back; Haiyan Chen; Ju Chen; Wenqian Chen; Heping Cheng; Henry J Duff; Arthur M Feldman; Michael Fill; Anne M Gillis; Ang Guo; Dawei Jiang; Peter P Jones; Xiaodong Li; Chris D Smith; Long-Sheng Song; Xixi Tian; Kannan Vembaiyan; Aixia Wang; Ruiwu Wang; Jianmin Xiao; Cuihong Xie; Dongmei Yang; Jingqun Zhang; Lin Zhang; Xiaowei Zhong; S R Wayne Chen
Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release.
Nature medicine 2011;17(8):1003-9.
2011: Xiuqin Zhang; Yan Zhang; Wen Zheng; Tiangang Zhu; Heping Cheng; Yi Ding; Chao Han; Ning Hou; Chuanyun Li; Kaitao Li; Na Liu; Yuli Liu; Jiaming Mao; Susanne Raab; Elena Sebokova; Shujiang Shang; Zhentao Song; Hui Wang; Jue Wang; Lifang Xue; Huiliang Zhang; Rongli Zhang; Paul L Huang
Rhesus macaques develop metabolic syndrome with reversible vascular dysfunction responsive to pioglitazone.
Circulation 2011;124(1):77-86.
2011: Didier Brochet; Wenjun Xie; Dongmei Yang; Heping Cheng; William Lederer
Quarky calcium release in the heart.
Circulation research 2011;108(2):210-8.
2010: Wenjun Xie; Didier Brochet; Sheng Wei; Xianhua Wang; Heping Cheng
Deciphering ryanodine receptor array operation in cardiac myocytes.
The Journal of general physiology 2010;136(2):129-33.
2010: Xianhua Wang; Wenjun Xie; Yi Zhang; Peihui Lin; Liang Han; Peidong Han; Yanru Wang; Zheng Chen; Guangju Ji; Ming Zheng; Noah Weisleder; Rui-Ping Xiao; Hiroshi Takeshima; Jianjie Ma; Heping Cheng
Cardioprotection of ischemia/reperfusion injury by cholesterol-dependent MG53-mediated membrane repair.
Circulation research 2010;107(1):76-83.
2010: Chaoliang Wei; Xianhua Wang; Min Chen; Kunfu Ouyang; Ming Zheng; Heping Cheng
Flickering calcium microdomains signal turning of migrating cells.
Canadian journal of physiology and pharmacology 2010;88(2):105-10.
2010: Wei Peng; Yan Zhang; Ming Zheng; Heping Cheng; Weizhong Zhu; Chun-Mei Cao; Rui-Ping Xiao
Cardioprotection by CaMKII-deltaB is mediated by phosphorylation of heat shock factor 1 and subsequent expression of inducible heat shock protein 70.
Circulation research 2010;106(1):102-10.
2010: Luyao Lu; Ling Xia; Xuesong Ye; Heping Cheng
Simulation of the effect of rogue ryanodine receptors on a calcium wave in ventricular myocytes with heart failure.
Physical biology 2010;7(2):026005.
2009: Peng Zhou; Yan-Ting Zhao; Yun-Bo Guo; Shi-Ming Xu; Shu-Hua Bai; Edward G Lakatta; Heping Cheng; Xue-Mei Hao; Shi-Qiang Wang
Beta-adrenergic signaling accelerates and synchronizes cardiac ryanodine receptor response to a single L-type Ca2+ channel.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(42):18028-33.
2009: Chaoliang Wei; Xianhua Wang; Min Chen; Kunfu Ouyang; Long-Sheng Song; Heping Cheng
Calcium flickers steer cell migration.
Nature 2009;457(7231):901-5.
2008: Heping Cheng; William Lederer
Calcium sparks.
Physiological reviews 2008;88(4):1491-545.
2008: Wang Wang; Huaqiang Fang; Linda Groom; Aiwu Cheng; Wanrui Zhang; Jie Liu; Xianhua Wang; Kaitao Li; Peidong Han; Ming Zheng; Jinhu Yin; Weidong Wang; Mark P Mattson; Joseph Kao; Edward G Lakatta; Shey-Shing Sheu; Kunfu Ouyang; Ju Chen; Robert T Dirksen; Heping Cheng
Superoxide flashes in single mitochondria.
Cell 2008;134(2):279-90.
2008: Dali Luo; Dongmei Yang; Xiaomei Lan; Kaitao Li; Xiaodong Li; Ju Chen; Youyi Zhang; Rui-Ping Xiao; Qide Han; Heping Cheng
Nuclear Ca2+ sparks and waves mediated by inositol 1,4,5-trisphosphate receptors in neonatal rat cardiomyocytes.
Cell calcium 2008;43(2):165-74.
2008: Yuan Yan; Jie Liu; Chaoliang Wei; Kaitao Li; Wenjun Xie; Yanru Wang; Heping Cheng
Bidirectional regulation of Ca2+ sparks by mitochondria-derived reactive oxygen species in cardiac myocytes.
Cardiovascular research 2008;77(2):432-41.
2007: Noah Weisleder; Christopher Ferrante; Yutaka Hirata; Claude Collet; Yi Chu; Heping Cheng; Hiroshi Takeshima; Jianjie Ma
Systemic ablation of RyR3 alters Ca2+ spark signaling in adult skeletal muscle.
Cell calcium 2007;42(6):548-55.
2007: Bailong Xiao; Xixi Tian; Wenjun Xie; Peter P Jones; Shitian Cai; Xianhua Wang; Dawei Jiang; Huihui Kong; Lin Zhang; Keyun Chen; Michael P Walsh; Heping Cheng; S R Wayne Chen
Functional consequence of protein kinase A-dependent phosphorylation of the cardiac ryanodine receptor: sensitization of store overload-induced Ca2+ release.
The Journal of biological chemistry 2007;282(41):30256-64.
2007: Guiling Zhao; Yan Zhao; Bingxing Pan; Jie Liu; Xuliang Huang; Xiuqin Zhang; Chunmei Cao; Ning Hou; Caihong Wu; Ke-Seng Zhao; Heping Cheng
Hypersensitivity of BKCa to Ca2+ sparks underlies hyporeactivity of arterial smooth muscle in shock.
Circulation research 2007;101(5):493-502.
2007: Tao Shen; Ming Zheng; Chunmei Cao; Chunlei Chen; Jian Tang; Wanrui Zhang; Heping Cheng; Kuang-Hueih Chen; Rui-Ping Xiao
Mitofusin-2 is a major determinant of oxidative stress-mediated heart muscle cell apoptosis.
The Journal of biological chemistry 2007;282(32):23354-61.
2007: Weizhong Zhu; Anthony Woo; Dongmei Yang; Heping Cheng; Michael T Crow; Rui-Ping Xiao
Activation of CaMKIIdeltaC is a common intermediate of diverse death stimuli-induced heart muscle cell apoptosis.
The Journal of biological chemistry 2007;282(14):10833-9.
2007: Dongmei Yang; Wei-Zhong Zhu; Bailong Xiao; Didier Brochet; S R Wayne Chen; Edward G Lakatta; Rui-Ping Xiao; Heping Cheng
Ca2+/calmodulin kinase II-dependent phosphorylation of ryanodine receptors suppresses Ca2+ sparks and Ca2+ waves in cardiac myocytes.
Circulation research 2007;100(3):399-407.
2007: Carlo G Tocchetti; Wang Wang; Jeffrey P Froehlich; Sabine Huke; Miguel A Aon; Gerald M Wilson; Giulietta Di Benedetto; Brian O'Rourke; Wei Dong Gao; David A Wink; John P Toscano; Manuela Zaccolo; Donald M Bers; Hector H Valdivia; Heping Cheng; David A Kass; Nazareno Paolocci
Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling.
Circulation research 2007;100(1):96-104.
2006: Li-jun Yao; Gang Wang; Kun-fu Ou-Yang; Chaoliang Wei; Xian-hua Wang; Shi-rong Wang; Wei Yao; Hong-ping Huang; Jian-Hong Luo; Cai-hong Wu; Jie Liu; Zhuan Zhou; Heping Cheng
Ca2+ sparks and Ca2+ glows in superior cervical ganglion neurons.
Acta pharmacologica Sinica 2006;27(7):848-52.
2006: Yuan Yan; Chaoliang Wei; Wan-rui Zhang; Heping Cheng; Jie Liu
Cross-talk between calcium and reactive oxygen species signaling.
Acta pharmacologica Sinica 2006;27(7):821-6.
2006: Zhe Feng; Chaoliang Wei; X Chen; J Wang; Heping Cheng; X Zhang; Quan Hong; S Shi; Bo Fu; R Wei
Essential role of Ca2+ release channels in angiotensin II-induced Ca2+ oscillations and mesangial cell contraction.
Kidney international 2006;70(1):130-8.
2006: Lie-Cheng Wang; Wei Xiong; Jing Zheng; Yang Zhou; Hui Zheng; Chen Zhang; Liang-Hong Zheng; Xue-Liang Zhu; Zhi-Qi Xiong; Lu-Yang Wang; Heping Cheng; Zhuan Zhou
The timing of endocytosis after activation of a G-protein-coupled receptor in a sensory neuron.
Biophysical journal 2006;90(10):3590-8.
2006: Bailong Xiao; Guofeng Zhong; Masakazu Obayashi; Dongmei Yang; Keyun Chen; Michael P Walsh; Yakhin Shimoni; Heping Cheng; Henk E D J ter Keurs; S R Wayne Chen
Ser-2030, but not Ser-2808, is the major phosphorylation site in cardiac ryanodine receptors responding to protein kinase A activation upon beta-adrenergic stimulation in normal and failing hearts.
The Biochemical journal 2006;396(1):7-16.
2006: Long-Sheng Song; Eric Sobie; Stacey L McCulle; William Lederer; C William Balke; Heping Cheng
Orphaned ryanodine receptors in the failing heart.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(11):4305-10.
2006: Tatiana M Vinogradova; Alexey E Lyashkov; Weizhong Zhu; Abdul M Ruknudin; Syevda G Sirenko; Dongmei Yang; Shekhar Deo; Matthew Barlow; Shavsha Johnson; James L Caffrey; Ying-Ying Zhou; Rui-Ping Xiao; Heping Cheng; Michael D Stern; Victor A Maltsev; Edward G Lakatta
High basal protein kinase A-dependent phosphorylation drives rhythmic internal Ca2+ store oscillations and spontaneous beating of cardiac pacemaker cells.
Circulation research 2006;98(4):505-14.
2005: Long-Sheng Song; YeQing Pi; Song-Jung Kim; Atsuko Yatani; Silvia Guatimosim; Raymond K Kudej; Qingxiu Zhang; Heping Cheng; Luc Hittinger; Bijan Ghaleh; Dorothy E Vatner; William Lederer; Stephen F Vatner
Paradoxical cellular Ca2+ signaling in severe but compensated canine left ventricular hypertrophy.
Circulation research 2005;97(5):457-64.
2005: Kunfu Ouyang; Hui Zheng; Xiaomei Qin; Chen Zhang; Dongmei Yang; Xian Wang; Caihong Wu; Zhuan Zhou; Heping Cheng
Ca2+ sparks and secretion in dorsal root ganglion neurons.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(34):12259-64.
2005: Wei-Zhong Zhu; Khalid Chakir; Shengjun Zhang; Dongmei Yang; Catherine Lavoie; Michel Bouvier; Terence E Hébert; Edward G Lakatta; Heping Cheng; Rui-Ping Xiao
Heterodimerization of beta1- and beta2-adrenergic receptor subtypes optimizes beta-adrenergic modulation of cardiac contractility.
Circulation research 2005;97(3):244-51.
2005: Xu Wang; Noah Weisleder; Claude Collet; Jingsong Zhou; Yi Chu; Yutaka Hirata; Xiaoli Zhao; Zui Pan; Marco Brotto; Heping Cheng; Jianjie Ma
Uncontrolled calcium sparks act as a dystrophic signal for mammalian skeletal muscle.
Nature cell biology 2005;7(5):525-30.
2005: Bailong Xiao; Ming Tao Jiang; Mingcai Zhao; Dongmei Yang; Cindy Sutherland; F Anthony Lai; Michael P Walsh; David C Warltier; Heping Cheng; S R Wayne Chen
Characterization of a novel PKA phosphorylation site, serine-2030, reveals no PKA hyperphosphorylation of the cardiac ryanodine receptor in canine heart failure.
Circulation research 2005;96(8):847-55.
2005: Kunfu Ouyang; Caihong Wu; Heping Cheng
Ca(2+)-induced Ca(2+) release in sensory neurons: low gain amplification confers intrinsic stability.
The Journal of biological chemistry 2005;280(16):15898-902.
2005: Didier Brochet; Dongmei Yang; Alessandro Di Maio; William Lederer; Clara Franzini-Armstrong; Heping Cheng
Ca2+ blinks: rapid nanoscopic store calcium signaling.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(8):3099-104.
2005: Xiangdong Xu; Dongmei Yang; Jian-Hua Ding; Wang Wang; Pao-Hsien Chu; Nancy Dalton; Huan-You Wang; Jamie Pennington; Zhen Ye; Forrest Liu; Michael G Rosenfeld; James L Manley; John Ross; Ju Chen; Rui-Ping Xiao; Heping Cheng; Xiang-Dong Fu
ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle.
Cell 2005;120(1):59-72.
2004: Xiaoling Yang; Wengong Wang; JINSHUI FAN; Ashish Lal; Dongmei Yang; Heping Cheng; Myriam Gorospe
Prostaglandin A2-mediated stabilization of p21 mRNA through an ERK-dependent pathway requiring the RNA-binding protein HuR.
The Journal of biological chemistry 2004;279(47):49298-306.
2004: Wang Wang; Weizhong Zhu; Shiqiang Wang; Dongmei Yang; Michael T Crow; Rui-Ping Xiao; Heping Cheng
Sustained beta1-adrenergic stimulation modulates cardiac contractility by Ca2+/calmodulin kinase signaling pathway.
Circulation research 2004;95(8):798-806.
2004: Dawei Jiang; Bailong Xiao; Dongmei Yang; Ruiwu Wang; Philip Choi; Lin Zhang; Heping Cheng; S R Wayne Chen
RyR2 mutations linked to ventricular tachycardia and sudden death reduce the threshold for store-overload-induced Ca2+ release (SOICR).
Proceedings of the National Academy of Sciences of the United States of America 2004;101(35):13062-7.
2004: Rui-Ping Xiao; Weizhong Zhu; Ming Zheng; Khalid Chakir; Richard Bond; Edward G Lakatta; Heping Cheng
Subtype-specific beta-adrenoceptor signaling pathways in the heart and their potential clinical implications.
Trends in pharmacological sciences 2004;25(7):358-65.
2004: Michael D Stern; Heping Cheng
Putting out the fire: what terminates calcium-induced calcium release in cardiac muscle?
Cell calcium 2004;35(6):591-601.
2004: Shi-Qiang Wang; Chaoliang Wei; Guiling Zhao; Didier Brochet; Jianxin Shen; Long-Sheng Song; Wang Wang; Dongmei Yang; Heping Cheng
Imaging microdomain Ca2+ in muscle cells.
Circulation research 2004;94(8):1011-22.
2004: Shi Qiang Wang; Michael D Stern; Eduardo Ríos; Heping Cheng
The quantal nature of Ca2+ sparks and in situ operation of the ryanodine receptor array in cardiac cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(11):3979-84.
2004: Jian-Hua Ding; Xiangdong Xu; Dongmei Yang; Pao-Hsien Chu; Nancy Dalton; Zhen Ye; Joanne M Yeakley; Heping Cheng; Rui-Ping Xiao; John Ross; Ju Chen; Xiang-Dong Fu
Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart.
The EMBO journal 2004;23(4):885-96.
2004: Jian-Xin Shen; ShiQiang Wang; Long-Sheng Song; Taizhen Han; Heping Cheng
Polymorphism of Ca2+ sparks evoked from in-focus Ca2+ release units in cardiac myocytes.
Biophysical journal 2004;86(1 Pt 1):182-90.
2003: Guang-Qin Zhang; Xue-Mei Hao; Shi-Zhong Chen; Pei-Ai Zhou; Heping Cheng; Cai-Hong Wu
Blockade of paeoniflorin on sodium current in mouse hippocampal CA1 neurons.
Acta pharmacologica Sinica 2003;24(12):1248-52.
2003: Khalid Chakir; Yang Xiang; Dongmei Yang; Sheng-Jun Zhang; Heping Cheng; Brian K Kobilka; Rui-Ping Xiao
The third intracellular loop and the carboxyl terminus of beta2-adrenergic receptor confer spontaneous activity of the receptor.
Molecular pharmacology 2003;64(5):1048-58.
2003: Rui-Ping Xiao; Sheng-Jun Zhang; Khalid Chakir; Pavel Avdonin; Weizhong Zhu; Richard A Bond; C William Balke; Edward G Lakatta; Heping Cheng
Enhanced G(i) signaling selectively negates beta2-adrenergic receptor (AR)--but not beta1-AR-mediated positive inotropic effect in myocytes from failing rat hearts.
Circulation 2003;108(13):1633-9.
2003: Dongmei Yang; Long-Sheng Song; Wei-Zhong Zhu; Khalid Chakir; Wei Wang; Caihong Wu; Yibin Wang; Rui-Ping Xiao; S R Wayne Chen; Heping Cheng
Calmodulin regulation of excitation-contraction coupling in cardiac myocytes.
Circulation research 2003;92(6):659-67.
2003: S Q Wang; Heping Cheng; Allen C Myers; Brendan J Canning; Kai Y Xu
Positive inotropic effect induced by sequence-specific Na+,K+-ATPase antibody in intact cardiac myocytes.
Annals of the New York Academy of Sciences 2003;986():630-2.
2003: Wei-Zhong Zhu; Shi-Qiang Wang; Khalid Chakir; Dongmei Yang; Tong Zhang; Joan Heller Brown; Eric Devic; Brian K Kobilka; Heping Cheng; Rui-Ping Xiao
Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II.
The Journal of clinical investigation 2003;111(5):617-25.
2002: Juliana Rengifo; Rafael Rosales; Adom González; Heping Cheng; Michael D Stern; Eduardo Ríos
Intracellular Ca(2+) release as irreversible Markov process.
Biophysical journal 2002;83(5):2511-21.
2002: Shi Qiang Wang; Edward G Lakatta; Heping Cheng; Zeng Quan Zhou
Adaptive mechanisms of intracellular calcium homeostasis in mammalian hibernators.
The Journal of experimental biology 2002;205(Pt 19):2957-62.
2002: Heping Cheng; Shi-Qiang Wang
Calcium signaling between sarcolemmal calcium channels and ryanodine receptors in heart cells.
Frontiers in bioscience : a journal and virtual library 2002;7():d1867-78.
2002: Shi-Qiang Wang; Long-Sheng Song; Le Xu; Gerhard Meissner; Edward G Lakatta; Eduardo Ríos; Michael D Stern; Heping Cheng
Thermodynamically irreversible gating of ryanodine receptors in situ revealed by stereotyped duration of release in Ca(2+) sparks.
Biophysical journal 2002;83(1):242-51.
2002: Zui Pan; Dongmei Yang; Ramakrishnan Y Nagaraj; Thomas A Nosek; Miyuki Nishi; Hiroshi Takeshima; Heping Cheng; Jianjie Ma
Dysfunction of store-operated calcium channel in muscle cells lacking mg29.
Nature cell biology 2002;4(5):379-83.
2002: Pu Liao; Shi-Qiang Wang; Su Wang; Ming Zheng; Meizi Zheng; Sheng-Jun Zhang; Heping Cheng; Yibin Wang; Rui-Ping Xiao
p38 Mitogen-activated protein kinase mediates a negative inotropic effect in cardiac myocytes.
Circulation research 2002;90(2):190-6.
2002: Long-Sheng Song; Antonio Guia; James N Muth; Marta Rubio; Shi-Qiang Wang; Rui-Ping Xiao; Ira R Josephson; Edward G Lakatta; Arnold Schwartz; Heping Cheng
Ca(2+) signaling in cardiac myocytes overexpressing the alpha(1) subunit of L-type Ca(2+) channel.
Circulation research 2002;90(2):174-81.
2001: Kai Y Xu; S Q Wang; Heping Cheng
Site-specific antibody of (Na(+) + K(+))-ATPase augments cardiac myocyte contraction without inactivating enzyme activity.
Biochemical and biophysical research communications 2001;289(1):167-72.
2001: Dongmei Yang; Z Pan; H Takeshima; C Wu; R Y Nagaraj; J Ma; Heping Cheng
RyR3 amplifies RyR1-mediated Ca(2+)-induced Ca(2+) release in neonatal mammalian skeletal muscle.
The Journal of biological chemistry 2001;276(43):40210-4.
2001: Laurel L Haak; L S Song; Tadeusz F Molinski; I N Pessah; Heping Cheng; James T Russell
Sparks and puffs in oligodendrocyte progenitors: cross talk between ryanodine receptors and inositol trisphosphate receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(11):3860-70.
2001: JH Wang; Hong-Wu Bian; Y X Zhang; Heping Cheng
The dual effect of antifreeze protein on cryopreservation of rice (Oryza sativa l.) embryogenic suspension cells.
Cryo letters 2001;22(3):175-82.
2001: Long-Sheng Song; Shi-Qiang Wang; Rui-Ping Xiao; Harold A Spurgeon; Edward G Lakatta; Heping Cheng
beta-Adrenergic stimulation synchronizes intracellular Ca(2+) release during excitation-contraction coupling in cardiac myocytes.
Circulation research 2001;88(8):794-801.
2001: Shi-Qiang Wang; Long-Sheng Song; Edward G Lakatta; Heping Cheng
Ca2+ signalling between single L-type Ca2+ channels and ryanodine receptors in heart cells.
Nature 2001;410(6828):592-6.
2001: Eduardo Ríos; Natalia Shirokova; WG Kirsch; Gonzalo Pizarro; Michael D Stern; Heping Cheng; Adom González
A preferred amplitude of calcium sparks in skeletal muscle.
Biophysical journal 2001;80(1):169-83.
2000: Ye Chen-Izu; Rui-Ping Xiao; Leighton Izu; Heping Cheng; Meike Kuschel; Harold A Spurgeon; Edward G Lakatta
G(i)-dependent localization of beta(2)-adrenergic receptor signaling to L-type Ca(2+) channels.
Biophysical journal 2000;79(5):2547-56.
2000: Ying-Ying Zhou; Dongmei Yang; Wei-Zhong Zhu; Sheng-Jun Zhang; D J Wang; Daniel K Rohrer; E Devic; Brian K Kobilka; Edward G Lakatta; Heping Cheng; Rui-Ping Xiao
Spontaneous activation of beta(2)- but not beta(1)-adrenoceptors expressed in cardiac myocytes from beta(1)beta(2) double knockout mice.
Molecular pharmacology 2000;58(5):887-94.
2000: Tatiana M Vinogradova; Ying-Ying Zhou; Konstantin Y Bogdanov; Dongmei Yang; Meike Kuschel; Heping Cheng; Rui-Ping Xiao
Sinoatrial node pacemaker activity requires Ca(2+)/calmodulin-dependent protein kinase II activation.
Circulation research 2000;87(9):760-7.
2000: Dirk Hagemann; Meike Kuschel; T Kuramochi; Weizhong Zhu; Heping Cheng; Rui-Ping Xiao
Frequency-encoding Thr17 phospholamban phosphorylation is independent of Ser16 phosphorylation in cardiac myocytes.
The Journal of biological chemistry 2000;275(29):22532-6.
2000: Sheng-Jun Zhang; Heping Cheng; Ying-Ying Zhou; D J Wang; Weizhong Zhu; Bruce D Ziman; H Spurgoen; RJ Lefkowitz; Edward G Lakatta; Walter J Koch; Rui-Ping Xiao
Inhibition of spontaneous beta 2-adrenergic activation rescues beta 1-adrenergic contractile response in cardiomyocytes overexpressing beta 2-adrenoceptor.
The Journal of biological chemistry 2000;275(28):21773-9.
2000: Ying-Ying Zhou; Shi-Qiang Wang; Wei-Zhong Zhu; AJ Chruscinski; Brian K Kobilka; Bruce D Ziman; Su Wang; Edward G Lakatta; Heping Cheng; Rui-Ping Xiao
Culture and adenoviral infection of adult mouse cardiac myocytes: methods for cellular genetic physiology.
American journal of physiology. Heart and circulatory physiology 2000;279(1):H429-36.
2000: Adom González; WG Kirsch; Natalia Shirokova; Gonzalo Pizarro; Gustavo Brum; I N Pessah; Michael D Stern; Heping Cheng; Eduardo Ríos
Involvement of multiple intracellular release channels in calcium sparks of skeletal muscle.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(8):4380-5.
2000: L S Song; G J Ren; Z L Chen; Zhi-He Chen; Zhao-Nian Zhou; Heping Cheng
Electrophysiological effects of protopine in cardiac myocytes: inhibition of multiple cation channel currents.
British journal of pharmacology 2000;129(5):893-900.
1999: Ying-Ying Zhou; Long-Sheng Song; Edward G Lakatta; Rui-Ping Xiao; Heping Cheng
Constitutive beta2-adrenergic signalling enhances sarcoplasmic reticulum Ca2+ cycling to augment contraction in mouse heart.
The Journal of physiology 1999;521 Pt 2():351-61.
1999: Rui-Ping Xiao; Heping Cheng; Ying-Ying Zhou; Meike Kuschel; Edward G Lakatta
Recent advances in cardiac beta(2)-adrenergic signal transduction.
Circulation research 1999;85(11):1092-100.
1999: Ying-Ying Zhou; Heping Cheng; Long-Sheng Song; D Wang; Edward G Lakatta; Rui-Ping Xiao
Spontaneous beta(2)-adrenergic signaling fails to modulate L-type Ca(2+) current in mouse ventricular myocytes.
Molecular pharmacology 1999;56(3):485-93.
1999: Meike Kuschel; Ying-Ying Zhou; Heping Cheng; Sheng-Jun Zhang; Ye Chen-Izu; Edward G Lakatta; Rui-Ping Xiao
G(i) protein-mediated functional compartmentalization of cardiac beta(2)-adrenergic signaling.
The Journal of biological chemistry 1999;274(31):22048-52.
1999: James N Muth; Hiroshi Yamaguchi; Gábor Mikala; Ingrid L Grupp; William Lewis; Heping Cheng; Long-Sheng Song; Edward G Lakatta; Gyula Varadi; Arnold Schwartz
Cardiac-specific overexpression of the alpha(1) subunit of the L-type voltage-dependent Ca(2+) channel in transgenic mice. Loss of isoproterenol-induced contraction.
The Journal of biological chemistry 1999;274(31):21503-6.
1999: Michael D Stern; Long-Sheng Song; Heping Cheng; James Sham; Huang-Tian Yang; Kenneth R Boheler; Eduardo Ríos
Local control models of cardiac excitation-contraction coupling. A possible role for allosteric interactions between ryanodine receptors.
The Journal of general physiology 1999;113(3):469-89.
1999: Natalia Shirokova; Adom González; WG Kirsch; Eduardo Ríos; Gonzalo Pizarro; Michael D Stern; Heping Cheng
Calcium sparks: release packets of uncertain origin and fundamental role.
The Journal of general physiology 1999;113(3):377-84.
1999: Heping Cheng; Long-Sheng Song; Natalia Shirokova; Adom González; Edward G Lakatta; Eduardo Ríos; Michael D Stern
Amplitude distribution of calcium sparks in confocal images: theory and studies with an automatic detection method.
Biophysical journal 1999;76(2):606-17.
1999: Rui-Ping Xiao; Pavel Avdonin; Ying-Ying Zhou; Heping Cheng; S A Akhter; T Eschenhagen; RJ Lefkowitz; Walter J Koch; Edward G Lakatta
Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes.
Circulation research 1999;84(1):43-52.
1998: James Sham; Long-Sheng Song; Ye Chen-Izu; L H Deng; Michael D Stern; Edward G Lakatta; Heping Cheng
Termination of Ca2+ release by a local inactivation of ryanodine receptors in cardiac myocytes.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(25):15096-101.
1998: Long-Sheng Song; James Sham; Michael D Stern; Edward G Lakatta; Heping Cheng
Direct measurement of SR release flux by tracking 'Ca2+ spikes' in rat cardiac myocytes.
The Journal of physiology 1998;512 ( Pt 3)():677-91.
1998: G D Smith; Joel Keizer; M D Stern; William Lederer; Heping Cheng
A simple numerical model of calcium spark formation and detection in cardiac myocytes.
Biophysical journal 1998;75(1):15-32.
1998: Rui-Ping Xiao; E D Tomhave; D J Wang; X Ji; Marvin O Boluyt; Heping Cheng; Edward G Lakatta; Walter J Koch
Age-associated reductions in cardiac beta1- and beta2-adrenergic responses without changes in inhibitory G proteins or receptor kinases.
The Journal of clinical investigation 1998;101(6):1273-82.
1997: Long-Sheng Song; Michael D Stern; Edward G Lakatta; Heping Cheng
Partial depletion of sarcoplasmic reticulum calcium does not prevent calcium sparks in rat ventricular myocytes.
The Journal of physiology 1997;505 ( Pt 3)():665-75.
1997: Ying-Ying Zhou; Heping Cheng; Konstantin Y Bogdanov; C Hohl; Ruth A Altschuld; Edward G Lakatta; Rui-Ping Xiao
Localized cAMP-dependent signaling mediates beta 2-adrenergic modulation of cardiac excitation-contraction coupling.
The American journal of physiology 1997;273(3 Pt 2):H1611-8.
1997: Ana Gomez; Héctor H Valdivia; Heping Cheng; M R Lederer; Luis F Santana; Mark Cannell; Sylvia A McCune; Ruth A Altschuld; William Lederer
Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure.
Science (New York, N.Y.) 1997;276(5313):800-6.
1997: Rui-Ping Xiao; Héctor H Valdivia; Konstantin Y Bogdanov; C Valdivia; Edward G Lakatta; Heping Cheng
The immunophilin FK506-binding protein modulates Ca2+ release channel closure in rat heart.
The Journal of physiology 1997;500 ( Pt 2)():343-54.
1997: Z Li; Heping Cheng; William Lederer; James B Froehlich; Edward G Lakatta
Enhanced proliferation and migration and altered cytoskeletal proteins in early passage smooth muscle cells from young and old rat aortic explants.
Experimental and molecular pathology 1997;64(1):1-11.
1996: Ana Gomez; Heping Cheng; William Lederer; Donald M Bers
Ca2+ diffusion and sarcoplasmic reticulum transport both contribute to [Ca2+]i decline during Ca2+ sparks in rat ventricular myocytes.
The Journal of physiology 1996;496 ( Pt 2)():575-81.
1996: Heping Cheng; M R Lederer; Rui-Ping Xiao; Ana Gomez; Ying-Ying Zhou; Bruce D Ziman; Harold A Spurgeon; Edward G Lakatta; William Lederer
Excitation-contraction coupling in heart: new insights from Ca2+ sparks.
Cell calcium 1996;20(2):129-40.
1996: William Lederer; S He; S Luo; William H duBell; P Kofuji; R Kieval; C F Neubauer; Abdul M Ruknudin; Heping Cheng; Mark Cannell; Terry B Rogers; Dan H Schulze
The molecular biology of the Na(+)-Ca2+ exchanger and its functional roles in heart, smooth muscle cells, neurons, glia, lymphocytes, and nonexcitable cells.
Annals of the New York Academy of Sciences 1996;779():7-17.
1996: Michael G Klein; Heping Cheng; Luis F Santana; Y H Jiang; William Lederer; Martin F Schneider
Two mechanisms of quantized calcium release in skeletal muscle.
Nature 1996;379(6564):455-8.
1996: Heping Cheng; M R Lederer; William Lederer; Mark Cannell
Calcium sparks and [Ca2+]i waves in cardiac myocytes.
The American journal of physiology 1996;270(1 Pt 1):C148-59.
1996: Luis F Santana; Heping Cheng; Ana Gomez; Mark Cannell; William Lederer
Relation between the sarcolemmal Ca2+ current and Ca2+ sparks and local control theories for cardiac excitation-contraction coupling.
Circulation research 1996;78(1):166-71.
1995: Mark T Nelson; Heping Cheng; M Rubart; L F Santana; Adrian D Bonev; Harry Knot; William Lederer
Relaxation of arterial smooth muscle by calcium sparks.
Science (New York, N.Y.) 1995;270(5236):633-7.
1995: Mark Cannell; Heping Cheng; William Lederer
The control of calcium release in heart muscle.
Science (New York, N.Y.) 1995;268(5213):1045-9.
1995: Heping Cheng; M Fill; H Valdivia; William Lederer
Models of Ca2+ release channel adaptation.
Science (New York, N.Y.) 1995;267(5206):2009-10.
1995: Heping Cheng; Mark Cannell; William Lederer
Partial inhibition of Ca2+ current by methoxyverapamil (D600) reveals spatial nonuniformities in [Ca2+]i during excitation-contraction coupling in cardiac myocytes.
Circulation research 1995;76(2):236-41.
1994: Mark Cannell; Heping Cheng; William Lederer
Spatial non-uniformities in [Ca2+]i during excitation-contraction coupling in cardiac myocytes.
Biophysical journal 1994;67(5):1942-56.
1994: Heping Cheng; Mark Cannell; William Lederer
Propagation of excitation-contraction coupling into ventricular myocytes.
Pflügers Archiv : European journal of physiology 1994;428(3-4):415-7.
1994: R P Xiao; Heping Cheng; William Lederer; T Suzuki; Edward G Lakatta
Dual regulation of Ca2+/calmodulin-dependent kinase II activity by membrane voltage and by calcium influx.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(20):9659-63.
1994: Ernst Niggli; D W Piston; M S Kirby; Heping Cheng; D R Sandison; W W Webb; William Lederer
A confocal laser scanning microscope designed for indicators with ultraviolet excitation wavelengths.
The American journal of physiology 1994;266(1 Pt 1):C303-10.
1993: Heping Cheng; William Lederer; Mark Cannell
Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle.
Science (New York, N.Y.) 1993;262(5134):740-4.