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Jacqueline Cherfils

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Jacqueline Cherfils; John R Helliwell; Thierry Prangé; Nori Sakabe; Michèle Sauvage; J Friso van der Veen
Roger Fourme (1942-2012).
Pablo Rougerie; Lara Toffali; Mahel Zeghouf; Georges Bismuth; florent carrette; Jacqueline Cherfils; Gabriela Constantin; Quitterie Largeteau; Carlo Laudanna; Thomas Lejeune; Marianne Mangeney; Laura Megrelis; Barbara Rossi; Jérôme Delon
Fam65b is a new transcriptional target of FOXO1 that regulates RhoA signaling for T lymphocyte migration.
Dominique Padovani; Jose Angel Traverso; Mahel Zeghouf; Carmela Giglione; Jacqueline Cherfils
High yield production of myristoylated Arf6 small GTPase by recombinant N-myristoyl transferase.

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All Publications

2013: Jacqueline Cherfils; John R Helliwell; Thierry Prangé; Nori Sakabe; Michèle Sauvage; J Friso van der Veen
Roger Fourme (1942-2012).
Journal of synchrotron radiation 2013;20(Pt 2):390-2.
2013: Pablo Rougerie; Lara Toffali; Mahel Zeghouf; Georges Bismuth; florent carrette; Jacqueline Cherfils; Gabriela Constantin; Quitterie Largeteau; Carlo Laudanna; Thomas Lejeune; Marianne Mangeney; Laura Megrelis; Barbara Rossi; Jérôme Delon
Fam65b is a new transcriptional target of FOXO1 that regulates RhoA signaling for T lymphocyte migration.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(2):748-55.
2013: Dominique Padovani; Jose Angel Traverso; Mahel Zeghouf; Carmela Giglione; Jacqueline Cherfils
High yield production of myristoylated Arf6 small GTPase by recombinant N-myristoyl transferase.
Small GTPases 2013;4(1):3-8.
2013: Jacqueline Cherfils; Mahel Zeghouf
Regulation of small GTPases by GEFs, GAPs, and GDIs.
Physiological reviews 2013;93(1):269-309.
2012: Eric Alix; Brad J Bowzard; Jacqueline Cherfils; Laurent Chesnel; Anna Delprato; Richard A Kahn; Aimee M Tucker; David O Wood; Craig R Roy
The capping domain in RalF regulates effector functions.
PLoS pathogens 2012;8(11):e1003012.
2011: Jacqueline Cherfils; Mahel Zeghouf
Chronicles of the GTPase switch.
Nature chemical biology 2011;7(8):493-5.
2010: Vanessa Buosi; Jean-Pierre Placial; Jean-Louis Leroy; Jacqueline Cherfils; Éric Guittet; Carine van Heijenoort
Insight into the role of dynamics in the conformational switch of the small GTP-binding protein Arf1.
The Journal of biological chemistry 2010;285(49):37987-94.
2010: Dominico Vigil; Jacqueline Cherfils; Kent L Rossman; Channing J Der
Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?
Nature reviews. Cancer 2010;10(12):842-57.
2010: Frédéric Boal; Lucie Guetzoyan; Richard B Sessions; Mahel Zeghouf; Robert Spooner; J Michael Lord; Jacqueline Cherfils; Guy J Clarkson; Lynne M Roberts; David J Stephens
LG186: An inhibitor of GBF1 function that causes Golgi disassembly in human and canine cells.
Traffic (Copenhagen, Denmark) 2010;11(12):1537-51.
2010: Valérie Biou; Kaheina Aizel; Pierre Roblin; Aurélien Thureau; Eric Jacquet; Sebastian Hansson; Bernard Guibert; Eric Guittet; Carine van Heijenoort; Mahel Zeghouf; Javier Perez; Jacqueline Cherfils
SAXS and X-ray crystallography suggest an unfolding model for the GDP/GTP conformational switch of the small GTPase Arf6.
Journal of molecular biology 2010;402(4):696-707.
2010: Bin Xia; Alexandra Joubert; Benjamin Groves; Kevin Vo; Davin Ashraf; Derek Djavaherian; Jason Awe; Ying Xiong; Jacqueline Cherfils; Dzwokai Ma
Modulation of cell adhesion and migration by the histone methyltransferase subunit mDpy-30 and its interacting proteins.
PloS one 2010;5(7):e11771.
2009: Nathalie Bouquier; Sylvie Fromont; Jean-Christophe Zeeh; Camille Auziol; Pauline Larrousse; Bruno Robert; Mahel Zeghouf; Jacqueline Cherfils; Anne Debant; Susanne Schmidt
Aptamer-derived peptides as potent inhibitors of the oncogenic RhoGEF Tgat.
Chemistry & biology 2009;16(4):391-400.
2008: Sebastian Flisiak; Jean-Christophe Zeeh; Bernard Guibert; Jacqueline Cherfils; Mahel Zeghouf
An Arf1 GTPase mutant with different responses to GEF inhibitors.
Biochemical and biophysical research communications 2008;377(1):156-60.
2008: Jean-Christophe Zeeh; Bruno Antonny; Jacqueline Cherfils; Mahel Zeghouf
In vitro assays to characterize inhibitors of the activation of small G proteins by their guanine nucleotide exchange factors.
Methods in enzymology 2008;438():41-56.
2007: Odile Ramaen; Alexandra Joubert; Philip Simister; Naïma Belgareh-Touzé; Maria Conception Olivares-Sanchez; Jean-Christophe Zeeh; Sophie Chantalat; Marie-Pierre Golinelli-Cohen; Catherine L Jackson; Valérie Biou; Jacqueline Cherfils
Interactions between conserved domains within homodimers in the BIG1, BIG2, and GBF1 Arf guanine nucleotide exchange factors.
The Journal of biological chemistry 2007;282(39):28834-42.
2007: Julien Viaud; Mahel Zeghouf; Hélène Barelli; Jean-Christophe Zeeh; André Padilla; Bernard Guibert; Pierre Chardin; Catherine A Royer; Jacqueline Cherfils; Alain Chavanieu
Structure-based discovery of an inhibitor of Arf activation by Sec7 domains through targeting of protein-protein complexes.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(25):10370-5.
2006: Guillaume Hible; P Daalova; Anne-Marie Gilles; Jacqueline Cherfils
Crystal structures of GMP kinase in complex with ganciclovir monophosphate and Ap5G.
Biochimie 2006;88(9):1157-64.
2006: Jean-Christophe Zeeh; Mahel Zeghouf; Cedric Grauffel; Bernard Guibert; Elyette Martin; Annick Dejaegere; Jacqueline Cherfils
Dual specificity of the interfacial inhibitor brefeldin a for arf proteins and sec7 domains.
The Journal of biological chemistry 2006;281(17):11805-14.
2006: Richard A Kahn; Jacqueline Cherfils; Marek Elias; Ruth C Lovering; Sean Munro; Annette Schurmann
Nomenclature for the human Arf family of GTP-binding proteins: ARF, ARL, and SAR proteins.
The Journal of cell biology 2006;172(5):645-50.
2006: Guillaume Hible; Petya Christova; Louis Renault; Edward Seclaman; Andrew Thompson; Eric Girard; Hélène Munier-Lehmann; Jacqueline Cherfils
Unique GMP-binding site in Mycobacterium tuberculosis guanosine monophosphate kinase.
Proteins 2006;62(2):489-500.
2005: Mahel Zeghouf; Bernard Guibert; Jean-Christophe Zeeh; Jacqueline Cherfils
Arf, Sec7 and Brefeldin A: a model towards the therapeutic inhibition of guanine nucleotide-exchange factors.
Biochemical Society transactions 2005;33(Pt 6):1265-8.
2005: Estelle Dransart; Birgitta Olofsson; Jacqueline Cherfils
RhoGDIs revisited: novel roles in Rho regulation.
Traffic (Copenhagen, Denmark) 2005;6(11):957-66.
2005: Guillaume Hible; Louis Renault; Francis Schaeffer; Petya Christova; Adriana Zoe Radulescu; Cécile Evrin; Anne-Marie Gilles; Jacqueline Cherfils
Calorimetric and crystallographic analysis of the oligomeric structure of Escherichia coli GMP kinase.
Journal of molecular biology 2005;352(5):1044-59.
2005: Jacqueline Cherfils; Paul Melançon
On the action of Brefeldin A on Sec7-stimulated membrane-recruitment and GDP/GTP exchange of Arf proteins.
Biochemical Society transactions 2005;33(Pt 4):635-8.
2005: Estelle Dransart; Annie Morin; Jacqueline Cherfils; Birgitta Olofsson
RhoGDI-3, a promising system to investigate the regulatory function of rhoGDIs: uncoupling of inhibitory and shuttling functions of rhoGDIs.
Biochemical Society transactions 2005;33(Pt 4):623-6.
2005: Aurélien Dupuy; Sébastien L'Hoste; Jacqueline Cherfils; Jacques Camonis; Georges Gaudriault; Jean de Gunzburg
Novel Rap1 dominant-negative mutants interfere selectively with C3G and Epac.
Oncogene 2005;24(28):4509-20.
2005: Sebastiano Pasqualato; Jacqueline Cherfils
Crystallographic evidence for substrate-assisted GTP hydrolysis by a small GTP binding protein.
Structure (London, England : 1993) 2005;13(4):533-40.
2005: Yves Pommier; Jacqueline Cherfils
Interfacial inhibition of macromolecular interactions: nature's paradigm for drug discovery.
Trends in pharmacological sciences 2005;26(3):138-45.
2005: Estelle Dransart; Annie Morin; Jacqueline Cherfils; Birgitta Olofsson
Uncoupling of inhibitory and shuttling functions of rho GDP dissociation inhibitors.
The Journal of biological chemistry 2005;280(6):4674-83.
2005: Barbara Mouratou; Valérie Biou; Alexandra Joubert; Jean Cohen; David J Shields; Niko Geldner; Gerd Jürgens; Paul Melançon; Jacqueline Cherfils
The domain architecture of large guanine nucleotide exchange factors for the small GTP-binding protein Arf.
BMC genomics 2005;6():20.
2004: Valérie Biou; Jacqueline Cherfils
Structural principles for the multispecificity of small GTP-binding proteins.
Biochemistry 2004;43(22):6833-40.
2004: Eric Macia; Frédéric Luton; Mariagrazia Partisani; Jacqueline Cherfils; Pierre Chardin; Michel Franco
The GDP-bound form of Arf6 is located at the plasma membrane.
Journal of cell science 2004;117(Pt 11):2389-98.
2004: Charles H Robert; Jacqueline Cherfils; Liliane Mouawad; david perahia
Integrating three views of Arf1 activation dynamics.
Journal of molecular biology 2004;337(4):969-83.
2004: Jacqueline Cherfils; Pierre Pacaud
[Activation of G-proteins in three dimensions: one step toward the therapeutic inhibition of nucleotide exchange factors].
Médecine sciences : M/S 2004;20(4):393-6.
2004: Sebastiano Pasqualato; Francesca Senic-Matuglia; Louis Renault; Bruno Goud; Jean Salamero; Jacqueline Cherfils
The structural GDP/GTP cycle of Rab11 reveals a novel interface involved in the dynamics of recycling endosomes.
The Journal of biological chemistry 2004;279(12):11480-8.
2003: Louis Renault; Bernard Guibert; Jacqueline Cherfils
Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor.
Nature 2003;426(6966):525-30.
2003: Katy Janvier; Heather Craig; Douglas Hitchin; Ricardo Madrid; Nathalie Sol-Foulon; Louis Renault; Jacqueline Cherfils; Dan Cassel; Serge Benichou; John C Guatelli
HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes.
The Journal of biological chemistry 2003;278(10):8725-32.
2003: Jacqueline Cherfils; Marc Chabre
Activation of G-protein Galpha subunits by receptors through Galpha-Gbeta and Galpha-Ggamma interactions.
Trends in biochemical sciences 2003;28(1):13-7.
2002: Sebastiano Pasqualato; Louis Renault; Jacqueline Cherfils
Arf, Arl, Arp and Sar proteins: a family of GTP-binding proteins with a structural device for 'front-back' communication.
EMBO reports 2002;3(11):1035-41.
2002: Louis Renault; Petya Christova; Bernard Guibert; Sebastiano Pasqualato; Jacqueline Cherfils
Mechanism of domain closure of Sec7 domains and role in BFA sensitivity.
Biochemistry 2002;41(11):3605-12.
2001: Jacqueline Cherfils
Structural mimicry of DH domains by Arfaptin suggests a model for the recognition of Rac-GDP by its guanine nucleotide exchange factors.
FEBS letters 2001;507(3):280-4.
2001: Sebastiano Pasqualato; Julie Ménétrey; Michel Franco; Jacqueline Cherfils
The structural GDP/GTP cycle of human Arf6.
EMBO reports 2001;2(3):234-8.
2001: Louis Renault; Pierre Kerjan; Sebastiano Pasqualato; Julie Ménétrey; Jean-Charles Robinson; S Kawaguchi; D G Vassylyev; S Yokoyama; Marc Mirande; Jacqueline Cherfils
Structure of the EMAPII domain of human aminoacyl-tRNA synthetase complex reveals evolutionary dimer mimicry.
The EMBO journal 2001;20(3):570-8.
2000: Joël Janin; Christian DUMAS; Solange Moréra; Y Xu; Philippe Meyer; M Chiadmi; Jacqueline Cherfils
Three-dimensional structure of nucleoside diphosphate kinase.
Journal of bioenergetics and biomembranes 2000;32(3):215-25.
2000: Julie Ménétrey; Eric Macia; Sebastiano Pasqualato; Michel Franco; Jacqueline Cherfils
Structure of Arf6-GDP suggests a basis for guanine nucleotide exchange factors specificity.
Nature structural biology 2000;7(6):466-9.
1999: M Chiadmi; Alda Navaza; Myroslawa Miginiac-Maslow; jean-pierre jacquot; Jacqueline Cherfils
Redox signalling in the chloroplast: structure of oxidized pea fructose-1,6-bisphosphate phosphatase.
The EMBO journal 1999;18(23):6809-15.
1999: Julie Ménétrey; Jacqueline Cherfils
Structure of the small G protein Rap2 in a non-catalytic complex with GTP.
Proteins 1999;37(3):465-73.
1999: Jacqueline Cherfils; Pierre Chardin
GEFs: structural basis for their activation of small GTP-binding proteins.
Trends in biochemical sciences 1999;24(8):306-11.
1999: Anne Peyroche; Bruno Antonny; Sylviane Robineau; Joel Acker; Jacqueline Cherfils; Catherine L Jackson
Brefeldin A acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex: involvement of specific residues of the Sec7 domain.
Molecular cell 1999;3(3):275-85.
1998: Sophie BERAUD-DUFOUR; Sylviane Robineau; Pierre Chardin; S Paris; Marc Chabre; Jacqueline Cherfils; Bruno Antonny
A glutamic finger in the guanine nucleotide exchange factor ARNO displaces Mg2+ and the beta-phosphate to destabilize GDP on ARF1.
The EMBO journal 1998;17(13):3651-9.
1998: Jacqueline Cherfils; Julie Ménétrey; M Mathieu; G Le Bras; Sylviane Robineau; Sophie BERAUD-DUFOUR; Bruno Antonny; Pierre Chardin
Structure of the Sec7 domain of the Arf exchange factor ARNO.
Nature 1998;392(6671):101-5.
1997: Jacqueline Cherfils; Julie Ménétrey; G Le Bras; Isabelle Janoueix-Lerosey; Jean de Gunzburg; JR Garel; I Auzat
Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS.
The EMBO journal 1997;16(18):5582-91.
1997: YW Xu; Solange Moréra; Joël Janin; Jacqueline Cherfils
AlF3 mimics the transition state of protein phosphorylation in the crystal structure of nucleoside diphosphate kinase and MgADP.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(8):3579-83.
1997: jean-pierre jacquot; J Lopez-Jaramillo; Myroslawa Miginiac-Maslow; Stéphane Lemaire; Jacqueline Cherfils; Ana Chueca; J Lopez-Gorge
Cysteine-153 is required for redox regulation of pea chloroplast fructose-1,6-bisphosphatase.
FEBS letters 1997;401(2-3):143-7.
1996: N C Strynadka; Miriam Eisenstein; Ephraim Katchalski-Katzir; Brian Shoichet; Irwin D Kuntz; Ruben Abagyan; Maxim Totrov; J Janin; Jacqueline Cherfils; F Zimmerman; A Olson; B Duncan; M Rao; R Jackson; M Sternberg; Michael N G James
Molecular docking programs successfully predict the binding of a beta-lactamase inhibitory protein to TEM-1 beta-lactamase.
Nature structural biology 1996;3(3):233-9.
1995: jean-pierre jacquot; J Lopez-Jaramillo; Ana Chueca; Jacqueline Cherfils; Stéphane Lemaire; B Chedozeau; Myroslawa Miginiac-Maslow; Paulette Decottignies; R Wolosiuk; J Lopez-Gorge
High-level expression of recombinant pea chloroplast fructose-1,6-bisphosphatase and mutagenesis of its regulatory site.
European journal of biochemistry / FEBS 1995;229(3):675-81.
1994: Jacqueline Cherfils; Solange Moréra; Ioan Lascu; Michel Véron; Joël Janin
X-ray structure of nucleoside diphosphate kinase complexed with thymidine diphosphate and Mg2+ at 2-A resolution.
Biochemistry 1994;33(31):9062-9.
1994: Michel Véron; A Tepper; M Hildebrandt; Ioan Lascu; Marie-Lise Lacombe; Joël Janin; Solange Moréra; Jacqueline Cherfils; Christian DUMAS; M Chiadmi
Nucleoside diphosphate kinase: an old enzyme with new functions?
Advances in experimental medicine and biology 1994;370():607-11.
1994: Jacqueline Cherfils; T Bizebard; Marcel Knossow; Joël Janin
Rigid-body docking with mutant constraints of influenza hemagglutinin with antibody HC19.
Proteins 1994;18(1):8-18.
1991: Jacqueline Cherfils; R Rosa; Marie-Claude Garel; M C Calvin; J Rosa; Joël Janin
Crystallization and preliminary X-ray diffraction studies of the human erythrocyte bisphosphoglycerate mutase.
Journal of molecular biology 1991;218(2):269-70.
1991: S Duquerroy; Jacqueline Cherfils; Joël Janin
Protein-protein interaction: an analysis by computer simulation.
Ciba Foundation symposium 1991;161():237-49; discussion 250-2.
1991: Jacqueline Cherfils; S Duquerroy; Joël Janin
Protein-protein recognition analyzed by docking simulation.
Proteins 1991;11(4):271-80.
1990: Jacqueline Cherfils; Patrice Vachette; Joël Janin
Modelling allosteric processes in E coli aspartate transcarbamylase.
Biochimie 1990;72(8):617-24.
1989: Jacqueline Cherfils; J F Gibrat; J Levin; J Batut; D Kahn
Model-building of Fnr and FixK DNA-binding domains suggests a basis for specific DNA recognition.
Journal of molecular recognition : JMR 1989;2(3):114-21.
1989: Jacqueline Cherfils; R M Sweet; S A Middleton; Evan R Kantrowitz; Patrick TAUC; Patrice Vachette
Structural consequences of a one atom mutation on aspartate transcarbamylase from E. coli.
FEBS letters 1989;247(2):361-6.
1987: Jacqueline Cherfils; Patrice Vachette; Patrick TAUC; Joël Janin
The pAR5 mutation and the allosteric mechanism of Escherichia coli aspartate carbamoyltransferase.
The EMBO journal 1987;6(9):2843-7.