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George Cherian

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Zhi-Min Liu; C Andrew van Hasselt; Fang-Zhou Song; Alexander C Vlantis; M George Cherian; James Koropatnick; George G Chen
Expression of functional metallothionein isoforms in papillary thyroid cancer.
Lina Yang; Hongyan Li; Ting Yu; Haijun Zhao; M George Cherian; Lu Cai; Ya Liu
Polymorphisms in metallothionein-1 and -2 genes associated with the risk of type 2 diabetes mellitus and its complications.
Elena A Ostrakhovitch; Per-Erik Olsson; Jonas von Hofsten; M George Cherian
P53 mediated regulation of metallothionein transcription in breast cancer cells.

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2009: Zhi-Min Liu; C Andrew van Hasselt; Fang-Zhou Song; Alexander C Vlantis; M George Cherian; James Koropatnick; George G Chen
Expression of functional metallothionein isoforms in papillary thyroid cancer.
Molecular and cellular endocrinology 2009;302(1):92-8.
2008: Lina Yang; Hongyan Li; Ting Yu; Haijun Zhao; M George Cherian; Lu Cai; Ya Liu
Polymorphisms in metallothionein-1 and -2 genes associated with the risk of type 2 diabetes mellitus and its complications.
American journal of physiology. Endocrinology and metabolism 2008;294(5):E987-92.
2007: Elena A Ostrakhovitch; Per-Erik Olsson; Jonas von Hofsten; M George Cherian
P53 mediated regulation of metallothionein transcription in breast cancer cells.
Journal of cellular biochemistry 2007;102(6):1571-83.
2007: Zhi-Min Liu; George G Chen; Cathy K Y Shum; Alexander C Vlantis; M George Cherian; James Koropatnick; C Andrew van Hasselt
Induction of functional MT1 and MT2 isoforms by calcium in anaplastic thyroid carcinoma cells.
FEBS letters 2007;581(13):2465-72.
2006: Yasuto Yamasaki; Cortney Smith; Dan Weisz; Isaac van Huizen; Jim W Xuan; Madeleine Moussa; Larry Stitt; Sakai Hideki; M George Cherian; Jonathan I Izawa
Metallothionein expression as prognostic factor for transitional cell carcinoma of bladder.
Urology 2006;67(3):530-5.
2006: Elena A Ostrakhovitch; Per-Erik Olsson; Sean Jiang; M George Cherian
Interaction of metallothionein with tumor suppressor p53 protein.
FEBS letters 2006;580(5):1235-8.
2006: M George Cherian; Y James Kang
Metallothionein and liver cell regeneration.
Experimental biology and medicine (Maywood, N.J.) 2006;231(2):138-44.
2006: Jordan R Oliver; Sean Jiang; M George Cherian
Augmented hepatic injury followed by impaired regeneration in metallothionein-I/II knockout mice after treatment with thioacetamide.
Toxicology and applied pharmacology 2006;210(3):190-9.
2005: Elena A Ostrakhovitch; M George Cherian
Inhibition of extracellular signal regulated kinase (ERK) leads to apoptosis inducing factor (AIF) mediated apoptosis in epithelial breast cancer cells: the lack of effect of ERK in p53 mediated copper induced apoptosis.
Journal of cellular biochemistry 2005;95(6):1120-34.
2005: Lu Cai; Xiao-Kun Li; Ye Song; M George Cherian
Essentiality, toxicology and chelation therapy of zinc and copper.
Current medicinal chemistry 2005;12(23):2753-63.
2005: Blanca P Esparza Gonzalez; Rodolfo Niño Fong; Candace J Gibson; I Carmen Fuentealba; M George Cherian
Zinc supplementation decreases hepatic copper accumulation in LEC rat: a model of Wilson's disease.
Biological trace element research 2005;105(1-3):117-34.
2005: Elena A Ostrakhovitch; M George Cherian
Role of p53 and reactive oxygen species in apoptotic response to copper and zinc in epithelial breast cancer cells.
Apoptosis : an international journal on programmed cell death 2005;10(1):111-21.
2005: Philip G Reeves; Rufus L Chaney; Robert W Simmons; M George Cherian
Metallothionein induction is not involved in cadmium accumulation in the duodenum of mice and rats fed diets containing high-cadmium rice or sunflower kernels and a marginal supply of zinc, iron, and calcium.
The Journal of nutrition 2005;135(1):99-108.
2005: Jordan R Oliver; Tom W Mara; M George Cherian
Impaired hepatic regeneration in metallothionein-I/II knockout mice after partial hepatectomy.
Experimental biology and medicine (Maywood, N.J.) 2005;230(1):61-7.
2004: Rodolfo Niño Fong; Blanca Patricia Esparza Gonzalez; I Carmen Fuentealba; M George Cherian
Role of tumor necrosis factor-alpha in the development of spontaneous hepatic toxicity in Long-Evans Cinnamon rats.
Toxicology and applied pharmacology 2004;200(2):121-30.
2004: Elena A Ostrakhovitch; M George Cherian
Differential regulation of signal transduction pathways in wild type and mutated p53 breast cancer epithelial cells by copper and zinc.
Archives of biochemistry and biophysics 2004;423(2):351-61.
2004: Lu Cai; Sam Iskander; M George Cherian; Robert R Hammond
Zinc- or cadmium-pre-induced metallothionein protects human central nervous system cells and astrocytes from radiation-induced apoptosis.
Toxicology letters 2004;146(3):217-26.
2003: M George Cherian; Anita Jayasurya; Boon-Huat Bay
Metallothioneins in human tumors and potential roles in carcinogenesis.
Mutation research 2003;533(1-2):201-9.
2003: Hernán Speisky; Paola Navarro; M George Cherian; Inés Jiménez
Copper-binding proteins in human erythrocytes: searching for potential biomarkers of copper over-exposure.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2003;16(1):113-23.
2003: Lu Cai; M George Cherian
Zinc-metallothionein protects from DNA damage induced by radiation better than glutathione and copper- or cadmium-metallothioneins.
Toxicology letters 2003;136(3):193-8.
2002: L Z Fan; M George Cherian
Potential role of p53 on metallothionein induction in human epithelial breast cancer cells.
British journal of cancer 2002;87(9):1019-26.
2002: Lu Cai; Shali Chen; Terry Evans; M George Cherian; Subrata Chakrabarti
Endothelin-1-mediated alteration of metallothionein and trace metals in the liver and kidneys of chronically diabetic rats.
International journal of experimental diabetes research 2002;3(3):193-8.
2002: Wei Qu; Bhalchandra A Diwan; Jie Liu; Robert A Goyer; Tammy Dawson; John L Horton; M George Cherian; Michael P Waalkes
The metallothionein-null phenotype is associated with heightened sensitivity to lead toxicity and an inability to form inclusion bodies.
The American journal of pathology 2002;160(3):1047-56.
2002: Jason D Czachor; M George Cherian; James Koropatnick
Reduction of copper and metallothionein in toxic milk mice by tetrathiomolybdate, but not deferiprone.
Journal of inorganic biochemistry 2002;88(2):213-22.
2002: M George Cherian; Yutaka Suzuki; Margarita Dimitrova Apostolova
Mouse astrocyte cultures used to study antioxidant property of metallothionein isoforms.
Methods in enzymology 2002;348():337-42.
2001: JC Lau; Linda Jackson-Boeters; Tom D Daley; George P Wysocki; M George Cherian
Metallothionein in human gingival amalgam tattoos.
Archives of oral biology 2001;46(11):1015-20.
2001: Margarita Dimitrova Apostolova; Shali Chen; Subrata Chakrabarti; M George Cherian
High-glucose-induced metallothionein expression in endothelial cells: an endothelin-mediated mechanism.
American journal of physiology. Cell physiology 2001;281(3):C899-907.
2001: Mariamma G Joseph; D Banerjee; Walter Kocha; R Feld; Larry Stitt; M George Cherian
Metallothionein expression in patients with small cell carcinoma of the lung: correlation with other molecular markers and clinical outcome.
Cancer 2001;92(4):836-42.
2001: Lu Cai; James Koropatnick; M George Cherian
Roles of vitamin C in radiation-induced DNA damage in presence and absence of copper.
Chemico-biological interactions 2001;137(1):75-88.
2000: Shali Chen; Margarita Dimitrova Apostolova; M George Cherian; Subrata Chakrabarti
Interaction of endothelin-1 with vasoactive factors in mediating glucose-induced increased permeability in endothelial cells.
Laboratory investigation; a journal of technical methods and pathology 2000;80(8):1311-21.
2000: Lu Cai; M George Cherian; Sam Iskander; M Leblanc; Robert R Hammond
Metallothionein induction in human CNS in vitro: neuroprotection from ionizing radiation.
International journal of radiation biology 2000;76(7):1009-17.
2000: Margarita Dimitrova Apostolova; M George Cherian
Delay of M-phase onset by aphidicolin can retain the nuclear localization of zinc and metallothionein in 3T3-L1 fibroblasts.
Journal of cellular physiology 2000;183(2):247-53.
2000: Y Suzuki; Margarita Dimitrova Apostolova; M George Cherian
Astrocyte cultures from transgenic mice to study the role of metallothionein in cytotoxicity of tert-butyl hydroperoxide.
Toxicology 2000;145(1):51-62.
2000: SI Ono; L Cai; James Koropatnick; M George Cherian
Radiation exposure does not alter metallothionein III isoform expression in mouse brain.
Biological trace element research 2000;74(1):23-30.
2000: Lu Cai; DX Deng; Jifu Jiang; Shali Chen; Robert Zhong; M George Cherian; Subrata Chakrabarti
Induction of metallothionein synthesis with preservation of testicular function in rats following long term renal transplantation.
Urological research 2000;28(2):97-103.
2000: M George Cherian; Margarita Dimitrova Apostolova
Nuclear localization of metallothionein during cell proliferation and differentiation.
Cellular and molecular biology (Noisy-le-Grand, France) 2000;46(2):347-56.
2000: Michael P Waalkes; S Rehm; M George Cherian
Repeated cadmium exposures enhance the malignant progression of ensuing tumors in rats.
Toxicological sciences : an official journal of the Society of Toxicology 2000;54(1):110-20.
2000: Margarita Dimitrova Apostolova; Iordanka A Ivanova; M George Cherian
Signal transduction pathways, and nuclear translocation of zinc and metallothionein during differentiation of myoblasts.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2000;78(1):27-37.
1999: Margarita Dimitrova Apostolova; Iordanka A Ivanova; M George Cherian
Metallothionein and apoptosis during differentiation of myoblasts to myotubes: protection against free radical toxicity.
Toxicology and applied pharmacology 1999;159(3):175-84.
1999: DX Deng; Lu Cai; Subrata Chakrabarti; M George Cherian
Increased radiation-induced apoptosis in mouse thymus in the absence of metallothionein.
Toxicology 1999;134(1):39-49.
1999: Lu Cai; G J Wang; K Mukherjee; Z L Xu; M Khalil; M George Cherian; Subrata Chakrabarti
Endothelins and their receptors in cirrhotic and neoplastic livers of Canadian and Chinese populations.
Anticancer research 1999;19(3B):2243-7.
1999: Lu Cai; M Satoh; C Tohyama; M George Cherian
Metallothionein in radiation exposure: its induction and protective role.
Toxicology 1999;132(2-3):85-98.
1999: Y Tamura; George P Wysocki; M George Cherian
Immunohistochemical localization of metallothionein in the developing teeth of cadmium-injected rats.
Archives of oral biology 1999;44(1):49-53.
1998: Lu Cai; G J Wang; Z L Xu; DX Deng; Subrata Chakrabarti; M George Cherian
Metallothionein and apoptosis in primary human hepatocellular carcinoma (HCC) from northern China.
Anticancer research 1998;18(6B):4667-72.
1998: Jonathan I Izawa; Madeleine Moussa; M George Cherian; Gordon S Doig; Joseph L Chin
Metallothionein expression in renal cancer.
Urology 1998;52(5):767-72.
1998: Lu Cai; G Tsiapalis; M George Cherian
Protective role of zinc-metallothionein on DNA damage in vitro by ferric nitrilotriacetate (Fe-NTA) and ferric salts.
Chemico-biological interactions 1998;115(2):141-51.
1998: SI Ono; Lu Cai; M George Cherian
Effects of gamma radiation on levels of brain metallothionein and lipid peroxidation in transgenic mice.
Radiation research 1998;150(1):52-7.
1998: JC Lau; Mariamma G Joseph; M George Cherian
Role of placental metallothionein in maternal to fetal transfer of cadmium in genetically altered mice.
Toxicology 1998;127(1-3):167-78.
1998: DX Deng; Subrata Chakrabarti; M P Waalkes; M George Cherian
Metallothionein and apoptosis in primary human hepatocellular carcinoma and metastatic adenocarcinoma.
Histopathology 1998;32(4):340-7.
1998: DX Deng; SI Ono; James Koropatnick; M George Cherian
Metallothionein and apoptosis in the toxic milk mutant mouse.
Laboratory investigation; a journal of technical methods and pathology 1998;78(2):175-83.
1998: JC Lau; M George Cherian
Developmental changes in hepatic metallothionein, zinc, and copper levels in genetically altered mice.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1998;76(4):615-23.
1998: SI Ono; M George Cherian
Changes in brain metallothionen and zinc during development in transgenic mice.
Biological trace element research 1998;61(1):41-9.
1997: Madeleine Moussa; D Kloth; G Peers; M George Cherian; J V Frei; Joseph L Chin
Metallothionein expression in prostatic carcinoma: correlation with Gleason grade, pathologic stage, DNA content and serum level of prostate-specific antigen.
Clinical and investigative medicine. Médecine clinique et experimentale 1997;20(6):371-80.
1997: Kamilia Rizkalla; M George Cherian
Metallothionein: a potential marker for differentiating benign and neoplastic gastrointestinal lymphoid infiltrates.
Pathology 1997;29(2):141-6.
1996: Lu Cai; M George Cherian
Adaptive response to ionizing radiation-induced chromosome aberrations in rabbit lymphocytes: effect of pre-exposure to zinc, and copper salts.
Mutation research 1996;369(3-4):233-41.
1995: J Koropatnick; D M Kloth; S Kadhim; Joseph L Chin; M George Cherian
Metallothionein expression and resistance to cisplatin in a human germ cell tumor cell line.
The Journal of pharmacology and experimental therapeutics 1995;275(3):1681-7.
1995: Lu Cai; James Koropatnick; M George Cherian
Metallothionein protects DNA from copper-induced but not iron-induced cleavage in vitro.
Chemico-biological interactions 1995;96(2):143-55.
1995: D M Kloth; Joseph L Chin; M George Cherian
Induction of hepatic metallothionein I in tumour-bearing mice.
British journal of cancer 1995;71(4):712-6.
1995: H Ohta; M George Cherian
The influence of nutritional deficiencies on gastrointestinal uptake of cadmium and cadmium-metallothionein in rats.
Toxicology 1995;97(1-3):71-80.
1995: A Albores; Christopher J Sinal; M George Cherian; John R Bend
Selective increase of rat lung cytochrome P450 1A1 dependent monooxygenase activity after acute sodium arsenite administration.
Canadian journal of physiology and pharmacology 1995;73(1):153-8.
1995: Christopher J Sinal; L F Zhu; Robert Zhong; M George Cherian; John R Bend
Liver transplantation induces cytochrome P450 1A1 dependent monooxygenase activity in rat lung and kidney.
Canadian journal of physiology and pharmacology 1995;73(1):146-52.
1994: M George Cherian
The significance of the nuclear and cytoplasmic localization of metallothionein in human liver and tumor cells.
Environmental health perspectives 1994;102 Suppl 3():131-5.
1994: M George Cherian; S B Howell; N Imura; C D Klaassen; James Koropatnick; John Lazo; Michael P Waalkes
Role of metallothionein in carcinogenesis.
Toxicology and applied pharmacology 1994;126(1):1-5.
1994: G F Stephenson; H M Chan; M George Cherian
Copper-metallothionein from the toxic milk mutant mouse enhances lipid peroxidation initiated by an organic hydroperoxide.
Toxicology and applied pharmacology 1994;125(1):90-6.
1994: J Yang; M George Cherian
Protective effects of metallothionein on streptozotocin-induced diabetes in rats.
Life sciences 1994;55(1):43-51.
1993: James Koropatnick; M George Cherian
A mutant mouse (tx) with increased hepatic metallothionein stability and accumulation.
The Biochemical journal 1993;296 ( Pt 2)():443-9.
1993: Joseph L Chin; D Banerjee; S A Kadhim; T E Kontozoglou; P J Chauvin; M George Cherian
Metallothionein in testicular germ cell tumors and drug resistance. Clinical correlation.
Cancer 1993;72(10):3029-35.
1993: H H Meskel; M George Cherian; V J Martinez; L A Veinot; J V Frei
Metallothionein as an epithelial proliferative compartment marker for DNA flow cytometry.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1993;6(6):755-60.
1993: H M Chan; L F Zhu; Robert Zhong; D Grant; R A Goyer; M George Cherian
Nephrotoxicity in rats following liver transplantation from cadmium-exposed rats.
Toxicology and applied pharmacology 1993;123(1):89-96.
1993: H M Chan; M George Cherian
Mobilization of hepatic cadmium in pregnant rats.
Toxicology and applied pharmacology 1993;120(2):308-14.
1993: M Satoh; D M Kloth; S A Kadhim; Joseph L Chin; Akira Naganuma; Nobumasa Imura; M George Cherian
Modulation of both cisplatin nephrotoxicity and drug resistance in murine bladder tumor by controlling metallothionein synthesis.
Cancer research 1993;53(8):1829-32.
1993: H M Chan; Y Tamura; M George Cherian; R A Goyer
Pregnancy-associated changes in plasma metallothionein concentration and renal cadmium accumulation in rats.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1993;202(4):420-7.
1993: X P Wang; H M Chan; R A Goyer; M George Cherian
Nephrotoxicity of repeated injections of cadmium-metallothionein in rats.
Toxicology and applied pharmacology 1993;119(1):11-6.
1993: H M Chan; M George Cherian
Ontogenic changes in hepatic metallothionein isoforms in prenatal and newborn rats.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1993;71(3-4):133-40.
1993: M George Cherian; P C Huang; C D Klaassen; Y P Liu; D G Longfellow; Michael P Waalkes
National Cancer Institute workshop on the possible roles of metallothionein in carcinogenesis.
Cancer research 1993;53(4):922-5.
1993: K C Falkner; G P McCallum; M George Cherian; John R Bend
Effects of acute sodium arsenite administration on the pulmonary chemical metabolizing enzymes, cytochrome P-450 monooxygenase, NAD(P)H:quinone acceptor oxidoreductase and glutathione S-transferase in guinea pig: comparison with effects in liver and kidney.
Chemico-biological interactions 1993;86(1):51-68.
1992: A Albores; James Koropatnick; M George Cherian; A J Zelazowski
Arsenic induces and enhances rat hepatic metallothionein production in vivo.
Chemico-biological interactions 1992;85(2-3):127-40.
1992: H M Chan; M Satoh; Rudolfs Zalups; M George Cherian
Exogenous metallothionein and renal toxicity of cadmium and mercury in rats.
Toxicology 1992;76(1):15-26.
1992: H M Chan; M George Cherian; I Bremner
Quantification of metallothionein isoforms using an enzyme-linked immunosorbent assay (ELISA) with two specific antisera.
Toxicology and applied pharmacology 1992;116(2):267-70.
1992: H M Chan; R Tabarrok; Y Tamura; M George Cherian
The relative importance of glutathione and metallothionein on protection of hepatotoxicity of menadione in rats.
Chemico-biological interactions 1992;84(2):113-24.
1992: R A Goyer; M Daria Haust; M George Cherian
Cellular localization of metallothionein in human term placenta.
Placenta 1992;13(4):349-55.
1992: H M Chan; M George Cherian
Protective roles of metallothionein and glutathione in hepatotoxicity of cadmium.
Toxicology 1992;72(3):281-90.
1992: R A Goyer; M George Cherian
Role of metallothionein in human placenta and rats exposed to cadmium.
IARC scientific publications 1992;(118):239-47.
1992: H M Chan; G A Pringle; M George Cherian
Heterogeneity of antibodies to metallothionein isomers and development of a simple enzyme-linked immunosorbent assay.
Journal of biochemical toxicology 1992;7(4):219-27.
1991: M E Leibrandt; James Koropatnick; JF Harris; M George Cherian
Radioimmunoassay of metallothionein in rabbit, rat, mouse, Chinese hamster, and human cells.
Biological trace element research 1991;30(3):245-56.
1991: H Ohta; M George Cherian
Gastrointestinal absorption of cadmium and metallothionein.
Toxicology and applied pharmacology 1991;107(1):63-72.
1991: C B Houghton; M George Cherian
Effects of inhibition of cystathionase activity on glutathione and metallothionein levels in the adult rat.
Journal of biochemical toxicology 1991;6(3):221-8.
1990: C A Suzuki; M George Cherian
The interactions of cis-diamminedichloroplatinum with metallothionein and glutathione in rat liver and kidney.
Toxicology 1990;64(2):113-27.
1990: C A Suzuki; H Ohta; A Albores; James Koropatnick; M George Cherian
Induction of metallothionein synthesis by zinc in cadmium pretreated rats.
Toxicology 1990;63(3):273-84.
1989: H Ohta; M V DeAngelis; M George Cherian
Uptake of cadmium and metallothionein by rat everted intestinal sacs.
Toxicology and applied pharmacology 1989;101(1):62-9.
1989: James Koropatnick; M Leibbrand; M George Cherian
Organ-specific metallothionein induction in mice by X irradiation.
Radiation research 1989;119(2):356-65.
1989: C A Suzuki; M George Cherian
Renal glutathione depletion and nephrotoxicity of cadmium-metallothionein in rats.
Toxicology and applied pharmacology 1989;98(3):544-52.
1989: K R Gallant; M George Cherian
Metabolic changes in glutathione and metallothionein in newborn rat liver.
The Journal of pharmacology and experimental therapeutics 1989;249(2):631-7.
1988: M George Cherian; E F Miles; T W Clarkson; C Cox
Estimation of mercury burdens in rats by chelation with dimercaptopropane sulfonate.
The Journal of pharmacology and experimental therapeutics 1988;245(2):479-84.
1988: C A Suzuki; M George Cherian
Effects of cadmium-metallothionein on renal organic ion transport and lipid peroxidation in rats.
Journal of biochemical toxicology 1988;3():11-20.
1988: James Koropatnick; M George Cherian
Exposure to different forms of cadmium in mice: differences in metallothionein and alphafetoprotein mRNA induction in liver and kidney.
Journal of biochemical toxicology 1988;3():159-72.
1987: N Nartey; M George Cherian; D Banerjee
Immunohistochemical localization of metallothionein in human thyroid tumors.
The American journal of pathology 1987;129(1):177-82.
1987: N O Nartey; J V Frei; M George Cherian
Hepatic copper and metallothionein distribution in Wilson's disease (hepatolenticular degeneration).
Laboratory investigation; a journal of technical methods and pathology 1987;57(4):397-401.
1987: N O Nartey; D Banerjee; M George Cherian
Immunohistochemical localization of metallothionein in cell nucleus and cytoplasm of fetal human liver and kidney and its changes during development.
Pathology 1987;19(3):233-8.
1987: M George Cherian; D M Templeton; K R Gallant; D Banerjee
Biosynthesis and metabolism of metallothionein in rat during perinatal development.
Experientia. Supplementum 1987;52():499-505.