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Maia Cherney

Research Profile

Procedures

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Chemicals & Drugs

Genes & Molecular Sequences

Amino Acid Sequences

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Mycobacterium tuberculosis

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Publications

TOP 3
Maia M Cherney; Michael N G James; Yanfei Zhang; Joel H Weiner
Structure-activity characterization of sulfide:quinone oxidoreductase variants.
Chunying Niu; Jiang Yin; Maia M Cherney; Michael N G James
Expression, purification and preliminary crystallographic analysis of Rv2247, the β subunit of acyl-CoA carboxylase (ACCD6) from Mycobacterium tuberculosis.
Maia M Cherney; Craig Garen; Leonid T Cherney; Michael N G James
The structures of Thermoplasma volcanium phosphoribosyl pyrophosphate synthetase bound to ribose-5-phosphate and ATP analogs.

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All Publications

2012: Maia M Cherney; Michael N G James; Yanfei Zhang; Joel H Weiner
Structure-activity characterization of sulfide:quinone oxidoreductase variants.
Journal of structural biology 2012;178(3):319-28.
2011: Chunying Niu; Jiang Yin; Maia M Cherney; Michael N G James
Expression, purification and preliminary crystallographic analysis of Rv2247, the β subunit of acyl-CoA carboxylase (ACCD6) from Mycobacterium tuberculosis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2011;67(Pt 12):1637-40.
2011: Maia M Cherney; Craig Garen; Leonid T Cherney; Michael N G James
The structures of Thermoplasma volcanium phosphoribosyl pyrophosphate synthetase bound to ribose-5-phosphate and ATP analogs.
Journal of molecular biology 2011;413(4):844-56.
2011: Maia M Cherney; Fabien Lecaille; Martin Kienitz; Ferez Nallaseth; Zhenqiang Li; Michael N G James; Dieter Brömme
Structure-activity analysis of cathepsin K/chondroitin 4-sulfate interactions.
The Journal of biological chemistry 2011;286(11):8988-98.
2011: Katherine S Bateman; Maia M Cherney; Don J Mahuran; Michael Tropak; Michael N G James
Crystal structure of β-hexosaminidase B in complex with pyrimethamine, a potential pharmacological chaperone.
Journal of medicinal chemistry 2011;54(5):1421-9.
2010: Leonid T Cherney; Maia M Cherney; Craig Garen; Michael N G James
Crystal structure of the intermediate complex of the arginine repressor from Mycobacterium tuberculosis bound with its DNA operator reveals detailed mechanism of arginine repression.
Journal of molecular biology 2010;399(2):240-54.
2010: Maia M Cherney; Yanfei Zhang; Matthew Solomonson; Joel Weiner; Michael N G James
Crystal structure of sulfide:quinone oxidoreductase from Acidithiobacillus ferrooxidans: insights into sulfidotrophic respiration and detoxification.
Journal of molecular biology 2010;398(2):292-305.
2010: Ramasamy Sankaranarayanan; Maia M Cherney; Craig Garen; Grace Garen; Chunying Niu; Marshall Yuan; Michael N G James
The molecular structure of ornithine acetyltransferase from Mycobacterium tuberculosis bound to ornithine, a competitive inhibitor.
Journal of molecular biology 2010;397(4):979-90.
2009: Yanfei Zhang; Maia M Cherney; Matthew Solomonson; Jianshe Liu; Michael N G James; Joel Weiner
Preliminary X-ray crystallographic analysis of sulfide:quinone oxidoreductase from Acidithiobacillus ferrooxidans.
Acta crystallographica. Section F, Structural biology and crystallization communications 2009;65(Pt 8):839-42.
2009: Leonid T Cherney; Maia M Cherney; Craig Garen; Michael N G James
The structure of the arginine repressor from Mycobacterium tuberculosis bound with its DNA operator and Co-repressor, L-arginine.
Journal of molecular biology 2009;388(1):85-97.
2009: R Sankaranarayanan; Craig Garen; Maia M Cherney; M Yuan; C Lee; M N G James
Preliminary X-ray crystallographic analysis of ornithine acetyltransferase (Rv1653) from Mycobacterium tuberculosis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2009;65(Pt 2):173-6.
2009: Bindu Pillai; Vijayalakshmi A Moorthie; Marco J van Belkum; Sandra L Marcus; Maia M Cherney; Christopher M Diaper; John C Vederas; Michael N G James
Crystal structure of diaminopimelate epimerase from Arabidopsis thaliana, an amino acid racemase critical for L-lysine biosynthesis.
Journal of molecular biology 2009;385(2):580-94.
2008: Leonid T Cherney; Maia M Cherney; Craig Garen; George J Lu; Michael N G James
Crystal structure of the arginine repressor protein in complex with the DNA operator from Mycobacterium tuberculosis.
Journal of molecular biology 2008;384(5):1330-40.
2008: Nobuhiko Watanabe; Matthew D Clay; Marco J van Belkum; Maia M Cherney; John C Vederas; Michael N G James
Mechanism of substrate recognition and PLP-induced conformational changes in LL-diaminopimelate aminotransferase from Arabidopsis thaliana.
Journal of molecular biology 2008;384(5):1314-29.
2008: Maia M Cherney; Craig Garen; Michael N G James
Crystal structure of Mycobacterium tuberculosis Rv0760c at 1.50 A resolution, a structural homolog of Delta(5)-3-ketosteroid isomerase.
Biochimica et biophysica acta 2008;1784(11):1625-32.
2008: Zhenqiang Li; Martin Kienetz; Maia M Cherney; Michael N G James; Dieter Brömme
The crystal and molecular structures of a cathepsin K:chondroitin sulfate complex.
Journal of molecular biology 2008;383(1):78-91.
2008: Bichitra K Biswal; Christophe Morisseau; Grace Garen; Maia M Cherney; Craig Garen; Chunying Niu; Bruce D Hammock; Michael N G James
The molecular structure of epoxide hydrolase B from Mycobacterium tuberculosis and its complex with a urea-based inhibitor.
Journal of molecular biology 2008;381(4):897-912.
2008: Jiang Yin; Craig Garen; Maia M Cherney; Leonid T Cherney; Michael N G James
Expression, purification and preliminary crystallographic analysis of N-acetylglucosamine-1-phosphate uridylyltransferase from Mycobacterium tuberculosis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 9):805-8.
2008: Leonid T Cherney; Maia M Cherney; Craig Garen; George J Lu; Michael N G James
Structure of the C-terminal domain of the arginine repressor protein from Mycobacterium tuberculosis.
Acta crystallographica. Section D, Biological crystallography 2008;64(Pt 9):950-6.
2008: Sarah J Witholt; Ramasamy Sankaranarayanan; Craig Garen; Maia M Cherney; Leonid T Cherney; Michael N G James
Expression, purification, crystallization and preliminary X-ray analysis of Rv3117, a probable thiosulfate sulfurtransferase (CysA3) from Mycobacterium tuberculosis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 6):541-4.
2008: Pooja A Mazumdar; Jordan C Hulecki; Maia M Cherney; Craig Garen; Michael N G James
X-ray crystal structure of Mycobacterium tuberculosis haloalkane dehalogenase Rv2579.
Biochimica et biophysica acta 2008;1784(2):351-62.
2008: Ramasamy Sankaranarayanan; Maia M Cherney; Leonid T Cherney; Craig Garen; Fatemeh Moradian; Michael N G James
The crystal structures of ornithine carbamoyltransferase from Mycobacterium tuberculosis and its ternary complex with carbamoyl phosphate and L-norvaline reveal the enzyme's catalytic mechanism.
Journal of molecular biology 2008;375(4):1052-63.
2007: Bindu Pillai; Maia M Cherney; Christopher M Diaper; Andrew Sutherland; John S Blanchard; John C Vederas; Michael N G James
Dynamics of catalysis revealed from the crystal structures of mutants of diaminopimelate epimerase.
Biochemical and biophysical research communications 2007;363(3):547-53.
2007: George J Lu; Craig Garen; Maia M Cherney; Leonid T Cherney; Cecilia Lee; Michael N G James
Expression, purification and preliminary X-ray analysis of the C-terminal domain of an arginine repressor protein from Mycobacterium tuberculosis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 11):936-9.
2007: Jiang Yin; Chunying Niu; Maia M Cherney; Jianmin Zhang; Carly Huitema; Lindsay D Eltis; John C Vederas; Michael N G James
A mechanistic view of enzyme inhibition and peptide hydrolysis in the active site of the SARS-CoV 3C-like peptidase.
Journal of molecular biology 2007;371(4):1060-74.
2007: Nobuhiko Watanabe; Maia M Cherney; Marco J van Belkum; Sandra L Marcus; Mitchel D Flegel; Matthew D Clay; Michael K Deyholos; John C Vederas; Michael N G James
Crystal structure of LL-diaminopimelate aminotransferase from Arabidopsis thaliana: a recently discovered enzyme in the biosynthesis of L-lysine by plants and Chlamydia.
Journal of molecular biology 2007;371(3):685-702.
2007: Leonid T Cherney; Maia M Cherney; Craig Garen; Chunying Niu; Fatemeh Moradian; Michael N G James
Crystal structure of N-acetyl-gamma-glutamyl-phosphate reductase from Mycobacterium tuberculosis in complex with NADP(+).
Journal of molecular biology 2007;367(5):1357-69.
2007: Ting-Wai Lee; Maia M Cherney; Jie Liu; Karen Ellis James; James C Powers; Lindsay D Eltis; Michael N G James
Crystal structures reveal an induced-fit binding of a substrate-like Aza-peptide epoxide to SARS coronavirus main peptidase.
Journal of molecular biology 2007;366(3):916-32.
2007: M Joanne Lemieux; Sarah J Fischer; Maia M Cherney; Katherine S Bateman; Michael N G James
The crystal structure of the rhomboid peptidase from Haemophilus influenzae provides insight into intramembrane proteolysis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(3):750-4.
2007: Bindu Pillai; Maia M Cherney; Kazumi Hiraga; Katsumi Takada; Kohei Oda; Michael N G James
Crystal structure of scytalidoglutamic peptidase with its first potent inhibitor provides insights into substrate specificity and catalysis.
Journal of molecular biology 2007;365(2):343-61.
2006: Craig Garen; Maia M Cherney; Ernst M Bergmann; Michael N G James
The molecular structure of Rv1873, a conserved hypothetical protein from Mycobacterium tuberculosis, at 1.38 A resolution.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 12):1201-5.
2006: Fatemeh Moradian; Craig Garen; Leonid T Cherney; Maia M Cherney; Michael N G James
Expression, purification, crystallization and preliminary X-ray analysis of two arginine-biosynthetic enzymes from Mycobacterium tuberculosis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 10):986-8.
2006: Jiang Yin; Maia M Cherney; Ernst M Bergmann; Jianmin Zhang; Carly Huitema; Hanna I Pettersson; Lindsay D Eltis; John C Vederas; Michael N G James
An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors.
Journal of molecular biology 2006;361(4):673-86.
2006: Bichitra K Biswal; Meitian Wang; Maia M Cherney; Laval Chan; Constantin G Yannopoulos; Darius Bilimoria; Jean Bedard; Michael N G James
Non-nucleoside inhibitors binding to hepatitis C virus NS5B polymerase reveal a novel mechanism of inhibition.
Journal of molecular biology 2006;361(1):33-45.
2006: Bichitra K Biswal; Karolyn Au; Maia M Cherney; Craig Garen; Michael N G James
The molecular structure of Rv2074, a probable pyridoxine 5'-phosphate oxidase from Mycobacterium tuberculosis, at 1.6 angstroms resolution.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 8):735-42.
2006: Marie E Fraser; Maia M Cherney; Paola Marcato; George L Mulvey; Glen D Armstrong; Michael N G James
Binding of adenine to Stx2, the protein toxin from Escherichia coli O157:H7.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 7):627-30.
2006: M Joanne Lemieux; Brian L Mark; Maia M Cherney; Stephen G Withers; Don J Mahuran; Michael N G James
Crystallographic structure of human beta-hexosaminidase A: interpretation of Tay-Sachs mutations and loss of GM2 ganglioside hydrolysis.
Journal of molecular biology 2006;359(4):913-29.
2006: Bindu Pillai; Maia M Cherney; Christopher M Diaper; Andrew Sutherland; John S Blanchard; John C Vederas; Michael N G James
Structural insights into stereochemical inversion by diaminopimelate epimerase: an antibacterial drug target.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(23):8668-73.
2006: Jiang Yin; Linda X Xu; Maia M Cherney; Evelyne Raux-Deery; Amanda A Bindley; Alexei Savchenko; John R Walker; Marianne E Cuff; Martin J Warren; Michael N G James
Crystal structure of the vitamin B12 biosynthetic cobaltochelatase, CbiXS, from Archaeoglobus fulgidus.
Journal of structural and functional genomics 2006;7(1):37-50.
2006: Jason T Maynes; Hue Anh Luu; Maia M Cherney; Raymond J Andersen; David Williams; Charles F B Holmes; Michael N G James
Crystal structures of protein phosphatase-1 bound to motuporin and dihydromicrocystin-LA: elucidation of the mechanism of enzyme inhibition by cyanobacterial toxins.
Journal of molecular biology 2006;356(1):111-20.
2006: Bichitra K Biswal; Grace Garen; Maia M Cherney; Craig Garen; Michael N G James
Cloning, expression, purification, crystallization and preliminary X-ray studies of epoxide hydrolases A and B from Mycobacterium tuberculosis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 2):136-8.
2005: Jiang Yin; Ernst M Bergmann; Maia M Cherney; Manjinder S Lall; Rajendra P Jain; John C Vederas; Michael N G James
Dual modes of modification of hepatitis A virus 3C protease by a serine-derived beta-lactone: selective crystallization and formation of a functional catalytic triad in the active site.
Journal of molecular biology 2005;354(4):854-71.
2005: M Joanne Lemieux; Claire Ference; Maia M Cherney; Metian Wang; Craig Garen; Michael N G James
The crystal structure of Rv0793, a hypothetical monooxygenase from M. tuberculosis.
Journal of structural and functional genomics 2005;6(4):245-57.
2005: Ting-Wai Lee; Maia M Cherney; Carly Huitema; Jie Liu; Karen Ellis James; James C Powers; Lindsay D Eltis; Michael N G James
Crystal structures of the main peptidase from the SARS coronavirus inhibited by a substrate-like aza-peptide epoxide.
Journal of molecular biology 2005;353(5):1137-51.
2005: Bichitra K Biswal; Maia M Cherney; Meitian Wang; Craig Garen; Michael N G James
Structures of Mycobacterium tuberculosispyridoxine 5'-phosphate oxidase and its complexes with flavin mononucleotide and pyridoxal 5'-phosphate.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 11):1492-9.
2005: Bichitra K Biswal; Maia M Cherney; Meitian Wang; Laval Chan; Constantin G Yannopoulos; Darius Bilimoria; Olivier Nicolas; Jean Bedard; Michael N G James
Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors.
The Journal of biological chemistry 2005;280(18):18202-10.
2005: Jason T Maynes; Maia M Cherney; MA Qasim; Michael Laskowski; Michael N G James
Structure of the subtilisin Carlsberg-OMTKY3 complex reveals two different ovomucoid conformations.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 5):580-8.
2004: Jason T Maynes; Kathleen R Perreault; Maia M Cherney; Hue Anh Luu; Michael N G James; Charles F B Holmes
Crystal structure and mutagenesis of a protein phosphatase-1:calcineurin hybrid elucidate the role of the beta12-beta13 loop in inhibitor binding.
The Journal of biological chemistry 2004;279(41):43198-206.
2004: Marie E Fraser; Masao Fujinaga; Maia M Cherney; Angela R Melton-Celsa; Edda M Twiddy; Alison D O'Brien; Michael N G James
Structure of shiga toxin type 2 (Stx2) from Escherichia coli O157:H7.
The Journal of biological chemistry 2004;279(26):27511-7.
2004: Masao Fujinaga; Maia M Cherney; Hiroshi Oyama; Kohei Oda; Michael N G James
The molecular structure and catalytic mechanism of a novel carboxyl peptidase from Scytalidium lignicolum.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(10):3364-9.
2003: Jason T Maynes; Craig Garen; Maia M Cherney; Gerald Newton; Dorit Arad; Yossef Av-Gay; Robert C Fahey; Michael N G James
The crystal structure of 1-D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) from Mycobacterium tuberculosis reveals a zinc hydrolase with a lactate dehydrogenase fold.
The Journal of biological chemistry 2003;278(47):47166-70.
2003: Isabelle H Barrette-Ng; Kenneth K-S Ng; Maia M Cherney; Gregory Pearce; Usman Ghani; Clarence A Ryan; Michael N G James
Unbound form of tomato inhibitor-II reveals interdomain flexibility and conformational variability in the reactive site loops.
The Journal of biological chemistry 2003;278(33):31391-400.
2003: Isabelle H Barrette-Ng; Kenneth K-S Ng; Maia M Cherney; Gregory Pearce; Clarence A Ryan; Michael N G James
Structural basis of inhibition revealed by a 1:2 complex of the two-headed tomato inhibitor-II and subtilisin Carlsberg.
The Journal of biological chemistry 2003;278(26):24062-71.
2003: Nina K Bernstein; Maia M Cherney; Charles A Yowell; John B Dame; Michael N G James
Structural insights into the activation of P. vivax plasmepsin.
Journal of molecular biology 2003;329(3):505-24.
2003: Brian L Mark; Don J Mahuran; Maia M Cherney; Dalian Zhao; Spencer Knapp; Michael N G James
Crystal structure of human beta-hexosaminidase B: understanding the molecular basis of Sandhoff and Tay-Sachs disease.
Journal of molecular biology 2003;327(5):1093-109.
2003: Meitian Wang; Kenneth K-S Ng; Maia M Cherney; Laval Chan; Constantin G Yannopoulos; Jean Bedard; Nicolas Morin; Nghe Nguyen-Ba; Moulay H Alaoui-Ismaili; Richard Bethell; Michael N G James
Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition.
The Journal of biological chemistry 2003;278(11):9489-95.
2002: Isabelle H Barrette-Ng; Kenneth K-S Ng; Brian L Mark; Danny Van Aken; Maia M Cherney; Craig Garen; Yuliya Kolodenko; Alexander E Gorbalenya; Eric J Snijder; Michael N G James
Structure of arterivirus nsp4. The smallest chymotrypsin-like proteinase with an alpha/beta C-terminal extension and alternate conformations of the oxyanion hole.
The Journal of biological chemistry 2002;277(42):39960-6.
2002: Kenneth K-S Ng; Maia M Cherney; Ana Lopez Vazquez; Angeles Machin; Jose M Martin Alonso; Francisco Parra; Michael N G James
Crystal structures of active and inactive conformations of a caliciviral RNA-dependent RNA polymerase.
The Journal of biological chemistry 2002;277(2):1381-7.
2001: Jason T Maynes; K S Bateman; Maia M Cherney; A K Das; Hue Anh Luu; Charles F B Holmes; Michael N G James
Crystal structure of the tumor-promoter okadaic acid bound to protein phosphatase-1.
The Journal of biological chemistry 2001;276(47):44078-82.
2000: Kenneth K-S Ng; JF Petersen; Maia M Cherney; Craig Garen; J J Zalatoris; C Rao-Naik; Ben M Dunn; M R Martzen; R J Peanasky; Michael N G James
Structural basis for the inhibition of porcine pepsin by Ascaris pepsin inhibitor-3.
Nature structural biology 2000;7(8):653-7.
2000: Masao Fujinaga; Maia M Cherney; NI Tarasova; Paul A Bartlett; J E Hanson; Michael N G James
Structural study of the complex between human pepsin and a phosphorus-containing peptidic -transition-state analog.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 3):272-9.
1999: Ernst M Bergmann; Maia M Cherney; JD McKendrick; S Frormann; C Luo; BA Malcolm; John C Vederas; Michael N G James
Crystal structure of an inhibitor complex of the 3C proteinase from hepatitis A virus (HAV) and implications for the polyprotein processing in HAV.
Virology 1999;265(1):153-63.
1999: JF Petersen; Maia M Cherney; Hans-Dieter Liebig; Tim Skern; Ernst Kuechler; Michael N G James
The structure of the 2A proteinase from a common cold virus: a proteinase responsible for the shut-off of host-cell protein synthesis.
The EMBO journal 1999;18(20):5463-75.
1999: Nina K Bernstein; Maia M Cherney; Hansruedi Loetscher; RG Ridley; Michael N G James
Crystal structure of the novel aspartic proteinase zymogen proplasmepsin II from plasmodium falciparum.
Nature structural biology 1999;6(1):32-7.
1997: AR Khan; Maia M Cherney; NI Tarasova; Michael N G James
Structural characterization of activation 'intermediate 2' on the pathway to human gastricsin.
Nature structural biology 1997;4(12):1010-5.
1997: Steven C Mosimann; Maia M Cherney; SK Sia; S Plotch; Michael N G James
Refined X-ray crystallographic structure of the poliovirus 3C gene product.
Journal of molecular biology 1997;273(5):1032-47.
1997: Natalie C J Strynadka; Maia M Cherney; A R Sielecki; Monica X Li; Lawrence B Smillie; Michael N G James
Structural details of a calcium-induced molecular switch: X-ray crystallographic analysis of the calcium-saturated N-terminal domain of troponin C at 1.75 A resolution.
Journal of molecular biology 1997;273(1):238-55.