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Iain Chessell

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Iain P Chessell; Amanda Dudley; Andy Billinton
Biologics: the next generation of analgesic drugs?
David J Davies; Paul Goldsmith; David Grose; Lee Abberley; Ezio Bettini; Novella Calcinaghi; Iain P Chessell; Matthew Crowe; James N C Kew; Nolwenn Lucas; Anton D Michel; David D Miller; Neil D Miller; Sara Pritchard; Joanna Quinn; Caterina Virginio; Martin J Gunthorpe
A novel series of benzimidazole NR2B-selective NMDA receptor antagonists.
Peter J Hanley; Carsten Kirschning; Volker Königs; Moritz Kronlage; Jens Leipziger; Otto Lindemann; Simon Mohr; Sarah Sargin; Hermann Schillers; Martin Bähler; Iain P Chessell; Adriana del Rey; Francesco Di Virgilio; Mikhail A Filippov; Albrecht Schwab
Transient P2X7 receptor activation triggers macrophage death independent of Toll-like receptors 2 and 4, caspase-1, and pannexin-1 proteins.

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2012: Iain P Chessell; Amanda Dudley; Andy Billinton
Biologics: the next generation of analgesic drugs?
Drug discovery today 2012;17(15-16):875-9.
2012: David J Davies; Paul Goldsmith; David Grose; Lee Abberley; Ezio Bettini; Novella Calcinaghi; Iain P Chessell; Matthew Crowe; James N C Kew; Nolwenn Lucas; Anton D Michel; David D Miller; Neil D Miller; Sara Pritchard; Joanna Quinn; Caterina Virginio; Martin J Gunthorpe
A novel series of benzimidazole NR2B-selective NMDA receptor antagonists.
Bioorganic & medicinal chemistry letters 2012;22(7):2620-3.
2012: Peter J Hanley; Carsten Kirschning; Volker Königs; Moritz Kronlage; Jens Leipziger; Otto Lindemann; Simon Mohr; Sarah Sargin; Hermann Schillers; Martin Bähler; Iain P Chessell; Adriana del Rey; Francesco Di Virgilio; Mikhail A Filippov; Albrecht Schwab
Transient P2X7 receptor activation triggers macrophage death independent of Toll-like receptors 2 and 4, caspase-1, and pannexin-1 proteins.
The Journal of biological chemistry 2012;287(13):10650-63.
2011: Jonathan P Hatcher; Iain P Chessell; Jane P Hughes
Biologics: the next-generation therapeutics for analgesia?
Expert review of neurotherapeutics 2011;11(11):1653-8.
2011: Jane Hughes; Jonathan P Hatcher; Iain P Chessell
Biologic drugs for analgesia: redefining the opportunity.
Current pharmaceutical biotechnology 2011;12(10):1660-70.
2011: Iain P Chessell; Jon Hatcher; Andy Billinton
Mechanistic differentiation of cancer pain: a pivotal role of P2X7 is absent.
Pain 2011;152(8):1703-4.
2009: Gerard M P Giblin; Andrew Billinton; Michael Briggs; Andrew J Brown; Iain P Chessell; Nick M Clayton; Andrew J Eatherton; Paul Goldsmith; Carl Haslam; Matthew R Johnson; William L Mitchell; Alan Naylor; Alcide Perboni; Brian P Slingsby; Alex W Wilson
Discovery of 1-[4-(3-chlorophenylamino)-1-methyl-1H-pyrrolo[3,2-c]pyridin-7-yl]-1-morpholin-4-ylmethanone (GSK554418A), a brain penetrant 5-azaindole CB2 agonist for the treatment of chronic pain.
Journal of medicinal chemistry 2009;52(19):5785-8.
2009: Martin E Swarbrick; Paul J Beswick; Robert J Gleave; Richard H Green; Sharon Bingham; Chas Bountra; Malcolm C Carter; Laura J Chambers; Iain P Chessell; Nick M Clayton; Sue D Collins; John A Corfield; C David Hartley; Savvas Kleanthous; Paul F Lambeth; Fiona S Lucas; Neil Mathews; Alan Naylor; Lee W Page; Jeremy J Payne; Neil A Pegg; Helen S Price; John Skidmore; Alexander J Stevens; Richard Stocker; Sharon C Stratton; Alastair J Stuart; Joanne O Wiseman
Identification of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidinyl] amines and ethers as potent and selective cyclooxygenase-2 inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(15):4504-8.
2009: William L Mitchell; Gerard M P Giblin; Alan Naylor; Andrew J Eatherton; Brian P Slingsby; Anthony D Rawlings; Karamjit S Jandu; Carl P Haslam; Andrew J Brown; Paul Goldsmith; Nick M Clayton; Alex W Wilson; Iain P Chessell; Richard H Green; Andrew R Whittington; Ian D Wall
Pyridine-3-carboxamides as novel CB(2) agonists for analgesia.
Bioorganic & medicinal chemistry letters 2009;19(1):259-63.
2008: Lauriane Ulmann; Jon P Hatcher; Jane P Hughes; Séverine Chaumont; Paula J Green; François Conquet; Gary N Buell; Alison J Reeve; Iain P Chessell; Francois Rassendren
Up-regulation of P2X4 receptors in spinal microglia after peripheral nerve injury mediates BDNF release and neuropathic pain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(44):11263-8.
2008: Penny C Staton; Jon P Hatcher; Deborah J Walker; Alastair D Morrison; Ellen M Shapland; Jane P Hughes; Elizabeth Chong; Palwinder K Mander; Paula J Green; Andy Billinton; Michael Fulleylove; Hilary C Lancaster; Jason C Smith; Leigh T Bailey; Alan Wise; Andrew J Brown; Jill C Richardson; Iain P Chessell
The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain.
Pain 2008;139(1):225-36.
2008: Uma Anand; William R Otto; Daniel Paulo Sánchez Herrera; Paul Facer; Yiangos Yiangou; Yuri Korchev; Rolfe Birch; Christopher Benham; Chas Bountra; Iain P Chessell; Praveen Anand
Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons.
Pain 2008;138(3):667-80.
2008: Stephen J Medhurst; Sue D Collins; Andy Billinton; Sharon Bingham; Robert G Dalziel; Amanda Brass; Jennifer C Roberts; Andrew D Medhurst; Iain P Chessell
Novel histamine H3 receptor antagonists GSK189254 and GSK334429 are efficacious in surgically-induced and virally-induced rat models of neuropathic pain.
Pain 2008;138(1):61-9.
2008: Stephen J Medhurst; Jon P Hatcher; Christopher J Hille; Sharon Bingham; Nicholas M Clayton; Andy Billinton; Iain P Chessell
Activation of the alpha7-nicotinic acetylcholine receptor reverses complete freund adjuvant-induced mechanical hyperalgesia in the rat via a central site of action.
The journal of pain : official journal of the American Pain Society 2008;9(7):580-7.
2008: Iain T Strickland; Jo C Martindale; Peter L Woodhams; Alison J Reeve; Iain P Chessell; Daniel S McQueen
Changes in the expression of NaV1.7, NaV1.8 and NaV1.9 in a distinct population of dorsal root ganglia innervating the rat knee joint in a model of chronic inflammatory joint pain.
European journal of pain (London, England) 2008;12(5):564-72.
2008: U Anand; W R Otto; Paul Facer; Noureddine Zebda; I Selmer; Martin Gunthorpe; Iain P Chessell; M Sinisi; Rolfe Birch; Praveen Anand
TRPA1 receptor localisation in the human peripheral nervous system and functional studies in cultured human and rat sensory neurons.
Neuroscience letters 2008;438(2):221-7.
2007: Jo C Martindale; Alex W Wilson; Alison J Reeve; Iain P Chessell; P M Headley
Chronic secondary hypersensitivity of dorsal horn neurones following inflammation of the knee joint.
Pain 2007;133(1-3):79-86.
2007: Yiangos Yiangou; Paul Facer; Iain P Chessell; Chas Bountra; Chris Chan; Caroline Fertleman; Virpi Smith; Praveen Anand
Voltage-gated ion channel Nav1.7 innervation in patients with idiopathic rectal hypersensitivity and paroxysmal extreme pain disorder (familial rectal pain).
Neuroscience letters 2007;427(2):77-82.
2007: Z Yilmaz; Tara Renton; Yiangos Yiangou; J Zakrzewska; Iain P Chessell; Chas Bountra; Praveen Anand
Burning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2007;14(9):864-71.
2007: Peter L Woodhams; Rachel E MacDonald; Sue D Collins; Iain P Chessell; Nicola C Day
Localisation and modulation of prostanoid receptors EP1 and EP4 in the rat chronic constriction injury model of neuropathic pain.
European journal of pain (London, England) 2007;11(6):605-13.
2007: Nicola J Barton; Iain T Strickland; Susan M Bond; Harry M Brash; Simon T Bate; Alex W Wilson; Iain P Chessell; Alison J Reeve; Daniel S McQueen
Pressure application measurement (PAM): a novel behavioural technique for measuring hypersensitivity in a rat model of joint pain.
Journal of neuroscience methods 2007;163(1):67-75.
2007: Gerard M P Giblin; Celestine T O'Shaughnessy; Alan Naylor; William L Mitchell; Andrew J Eatherton; Brian P Slingsby; D Anthony Rawlings; Paul Goldsmith; Andrew J Brown; Claudine Haslam; Nicholas M Clayton; Alex W Wilson; Iain P Chessell; Andrew R Wittington; Richard Green
Discovery of 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro- 2H-pyran-4-yl)methyl]-4-(trifluoromethyl)- 5-pyrimidinecarboxamide, a selective CB2 receptor agonist for the treatment of inflammatory pain.
Journal of medicinal chemistry 2007;50(11):2597-600.
2007: Anton D Michel; L J Chambers; William C Clay; J Patrick Condreay; D S Walter; Iain P Chessell
Direct labelling of the human P2X7 receptor and identification of positive and negative cooperativity of binding.
British journal of pharmacology 2007;151(1):103-14.
2007: Andrew D Medhurst; Michael A Briggs; Gordon Bruton; Andy Robert Calver; Iain P Chessell; Barry Crook; John B Davis; Robert P Davis; Andrew G Foley; Teresa Heslop; Warren D Hirst; Stephen J Medhurst; Sandrine Ociepka; Alison Ray; Ciaran M Regan; Becky Sargent; Joanne Schogger; Tania O Stean; Brenda K Trail; Neil Upton; Trevor White; Barry Orlek; David M Wilson
Structurally novel histamine H3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced secondary allodynia in rats.
Biochemical pharmacology 2007;73(8):1182-94.
2007: Penny C Staton; Alex W Wilson; Chas Bountra; Iain P Chessell; Nicola C Day
Changes in dorsal root ganglion CGRP expression in a chronic inflammatory model of the rat knee joint: differential modulation by rofecoxib and paracetamol.
European journal of pain (London, England) 2007;11(3):283-9.
2007: Stephen C McKeown; Adrian Hall; Richard Blunt; Susan H Brown; Iain P Chessell; Anita Chowdhury; Gerard M P Giblin; Mark P Healy; Matthew R Johnson; Olivier Lorthioir; Anton D Michel; Alan Naylor; Xiao Q Lewell; Shilina Roman; Stephen P Watson; Wendy J Winchester; Richard J Wilson
Identification of novel glycine sulfonamide antagonists for the EP1 receptor.
Bioorganic & medicinal chemistry letters 2007;17(6):1750-4.
2007: Jane P Hughes; Jonathan P Hatcher; Iain P Chessell
The role of P2X₇ in pain and inflammation.
Purinergic signalling 2007;3(1-2):163-9.
2007: Adrian Hall; Stephen Atkinson; Susan H Brown; Iain P Chessell; Anita Chowdhury; Gerard M P Giblin; Paul Goldsmith; Mark P Healy; Karamjit S Jandu; Matthew R Johnson; Anton D Michel; Alan Naylor; Jennifer Sweeting
Discovery of novel, non-acidic 1,5-biaryl pyrrole EP1 receptor antagonists.
Bioorganic & medicinal chemistry letters 2007;17(5):1200-5.
2007: Fei-Yue Zhao; Dave Spanswick; Jo C Martindale; Alison J Reeve; Iain P Chessell
GW406381, a novel COX-2 inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury.
Pain 2007;128(1-2):78-87.
2007: Adrian Hall; Susan H Brown; Iain P Chessell; Anita Chowdhury; Nicholas M Clayton; Tanya Coleman; Gerard M P Giblin; Beverley Hammond; Mark P Healy; Matthew R Johnson; Ann Metcalf; Anton D Michel; Alan Naylor; Riccardo Novelli; David J Spalding; Jennifer Sweeting; Lisa A Winyard
1,5-Biaryl pyrrole derivatives as EP1 receptor antagonists. Structure-activity relationships of 6-substituted and 5,6-disubstituted benzoic acid derivatives.
Bioorganic & medicinal chemistry letters 2007;17(4):916-20.
2007: Adrian Hall; Susan H Brown; Iain P Chessell; Anita Chowdhury; Nicholas M Clayton; Tanya Coleman; Gerard M P Giblin; Beverley Hammond; Mark P Healy; Matthew R Johnson; Ann Metcalf; Anton D Michel; Alan Naylor; Riccardo Novelli; David J Spalding; Jennifer Sweeting
1,5-Biaryl pyrrole derivatives as EP1 receptor antagonists: Structure-activity relationships of 4- and 5-substituted benzoic acid derivatives.
Bioorganic & medicinal chemistry letters 2007;17(3):732-5.
2007: Gerard M P Giblin; Rino A Bit; Susan H Brown; Helene Chaignot; Anita Chowdhury; Iain P Chessell; Nicholas M Clayton; Tanya Coleman; Adrian Hall; Beverley Hammond; David N Hurst; Anton D Michel; Alan Naylor; Riccardo Novelli; Tiziana Scoccitti; David J Spalding; Sac P Tang; Alex W Wilson; Rich Wilson
The discovery of 6-[2-(5-chloro-2-{[(2,4-difluorophenyl)methyl]oxy}phenyl)-1-cyclopenten-1-yl]-2-pyridinecarboxylic acid, GW848687X, a potent and selective prostaglandin EP1 receptor antagonist for the treatment of inflammatory pain.
Bioorganic & medicinal chemistry letters 2007;17(2):385-9.
2007: Nicola J Barton; David A Stevens; Jane P Hughes; Adriano G Rossi; Iain P Chessell; Alison J Reeve; Daniel S McQueen
Demonstration of a novel technique to quantitatively assess inflammatory mediators and cells in rat knee joints.
Journal of inflammation (London, England) 2007;4():13.
2007: Paul Facer; Maria A Casula; Graham D Smith; Christopher D Benham; Iain P Chessell; Chas Bountra; Marco Sinisi; Rolfe Birch; Praveen Anand
Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy.
BMC neurology 2007;7():11.
2006: Fumimasa Amaya; Haibin Wang; Michael Costigan; Andrew J Allchorne; Jonathan P Hatcher; Julie Egerton; Tania O Stean; Valerie Morisset; David Grose; Martin Gunthorpe; Iain P Chessell; Simon Tate; Paula J Green; Clifford J Woolf
The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(50):12852-60.
2006: Sharon Bingham; Paul J Beswick; David E Blum; Norman M Gray; Iain P Chessell
The role of the cylooxygenase pathway in nociception and pain.
Seminars in cell & developmental biology 2006;17(5):544-54.
2006: Nicola J Barton; Daniel S McQueen; D Thomson; Stephan D Gauldie; Alex W Wilson; D M Salter; Iain P Chessell
Attenuation of experimental arthritis in TRPV1R knockout mice.
Experimental and molecular pathology 2006;81(2):166-70.
2006: Stephen C McKeown; Adrian Hall; Gerard M P Giblin; Olivier Lorthioir; Richard Blunt; Xiao Q Lewell; Richard J Wilson; Susan H Brown; Anita Chowdhury; Tanya Coleman; Stephen P Watson; Iain P Chessell; Adrian Pipe; Nick Clayton; Paul Goldsmith
Identification of novel pyrazole acid antagonists for the EP1 receptor.
Bioorganic & medicinal chemistry letters 2006;16(18):4767-71.
2006: Stephen Skaper; Laura Facci; Ainsley A Culbert; Nicholas A Evans; Iain P Chessell; John B Davis; Jill C Richardson
P2X(7) receptors on microglial cells mediate injury to cortical neurons in vitro.
Glia 2006;54(3):234-42.
2006: Petra Schweinhardt; Chris Glynn; Jonathan Brooks; Henry J McQuay; Tim Jack; Iain P Chessell; Chas Bountra; Irene Tracey
An fMRI study of cerebral processing of brush-evoked allodynia in neuropathic pain patients.
NeuroImage 2006;32(1):256-65.
2006: Alex W Wilson; Stephen J Medhurst; Claire I Dixon; Nick C Bontoft; Lisa A Winyard; Kim T Brackenborough; Jorge De Alba; Christopher J Clarke; Martin Gunthorpe; Gareth Hicks; Chas Bountra; Daniel S McQueen; Iain P Chessell
An animal model of chronic inflammatory pain: pharmacological and temporal differentiation from acute models.
European journal of pain (London, England) 2006;10(6):537-49.
2006: Adrian Hall; Stephen Atkinson; Susan H Brown; Iain P Chessell; Anita Chowdhury; Nicholas M Clayton; Tanya Coleman; Gerard M P Giblin; Robert J Gleave; Beverley Hammond; Mark P Healy; Matthew R Johnson; Anton D Michel; Alan Naylor; Riccardo Novelli; David J Spalding; Sac P Tang
Structure-activity relationships of 1,5-biaryl pyrroles as EP1 receptor antagonists.
Bioorganic & medicinal chemistry letters 2006;16(14):3657-62.
2006: Jonathan P Hatcher; Iain P Chessell
Transgenic models of pain: a brief review.
Current opinion in investigational drugs (London, England : 2000) 2006;7(7):647-52.
2006: Caroline J Sharp; Alison J Reeve; Sue D Collins; Jo C Martindale; Scott G Summerfield; Becky S Sargent; Simon T Bate; Iain P Chessell
Investigation into the role of P2X(3)/P2X(2/3) receptors in neuropathic pain following chronic constriction injury in the rat: an electrophysiological study.
British journal of pharmacology 2006;148(6):845-52.
2006: Adrian Hall; Rino A Bit; Susan H Brown; Helene Chaignot; Iain P Chessell; Tanya Coleman; Gerard M P Giblin; David N Hurst; Ian R Kilford; Xiao Q Lewell; Anton D Michel; Shiyam Mohamed; Alan Naylor; Riccardo Novelli; Lee Skinner; David J Spalding; Sac P Tang; Richard J Wilson
Discovery of novel biaryl heterocyclic EP1 receptor antagonists.
Bioorganic & medicinal chemistry letters 2006;16(10):2666-71.
2006: Gaurav Mukerji; Janet Waters; Iain P Chessell; Chas Bountra; Sanjiv K Agarwal; Praveen Anand
Pain during ice water test distinguishes clinical bladder hypersensitivity from overactivity disorders.
BMC urology 2006;6():31.
2006: Yiangos Yiangou; Paul Facer; Pascal F Durrenberger; Iain P Chessell; Alan Naylor; Chas Bountra; Richard R Banati; Praveen Anand
COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord.
BMC neurology 2006;6():12.
2006: Pascal F Durrenberger; Paul Facer; Maria A Casula; Yiangos Yiangou; Roy A Gray; Iain P Chessell; Nicola C Day; Sue D Collins; Sharon Bingham; Alex W Wilson; David Elliot; Rolfe Birch; Praveen Anand
Prostanoid receptor EP1 and Cox-2 in injured human nerves and a rat model of nerve injury: a time-course study.
BMC neurology 2006;6():1.
2006: Jorge De Alba; Nick M Clayton; Sue D Collins; Philip Colthup; Iain P Chessell; Richard G Knowles
GW274150, a novel and highly selective inhibitor of the inducible isoform of nitric oxide synthase (iNOS), shows analgesic effects in rat models of inflammatory and neuropathic pain.
Pain 2006;120(1-2):170-81.
2005: Iain P Chessell; Jonathan P Hatcher; Chas Bountra; Anton D Michel; Jane P Hughes; Paula Green; Julie Egerton; Melanie Murfin; Jill Richardson; Wendy L Peck; Caroline B A Grahames; Maria A Casula; Yiangos Yiangou; Rolfe Birch; Praveen Anand; Gary N Buell
Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain.
Pain 2005;114(3):386-96.
2005: Sharon Bingham; Paul J Beswick; Chas Bountra; Terry Brown; Ian B Campbell; Iain P Chessell; Nick Clayton; Sue D Collins; Philip T Davey; Helen Goodland; Norman Gray; Claudine Haslam; Jonathan P Hatcher; A Jackie Hunter; Fiona Lucas; Graham Murkitt; Alan Naylor; Elizabeth Pickup; Becky Sargent; Scott G Summerfield; Alexander Stevens; Sharon C Stratton; Joanne Wiseman
The cyclooxygenase-2 inhibitor GW406381X [2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine] is effective in animal models of neuropathic pain and central sensitization.
The Journal of pharmacology and experimental therapeutics 2005;312(3):1161-9.
2005: Sue D Collins; Iain P Chessell
Emerging therapies for neuropathic pain.
Expert opinion on emerging drugs 2005;10(1):95-108.
2004: Paul J Beswick; Sharon Bingham; Chas Bountra; Terry Brown; Kerry Browning; Ian Campbell; Iain P Chessell; Nick Clayton; Sue Collins; John Corfield; Stephen Guntrip; Claudine Haslam; Paul Lambeth; Fiona Lucas; Neil Mathews; Graham Murkit; Alan Naylor; Neil Pegg; Elizabeth Pickup; Hazel Player; Helen Price; Alexander Stevens; Sharon Stratton; Joanne Wiseman
Identification of 2,3-diaryl-pyrazolo[1,5-b]pyridazines as potent and selective cyclooxygenase-2 inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(21):5445-8.
2004: Stephan D Gauldie; Daniel S McQueen; Christopher J Clarke; Iain P Chessell
A robust model of adjuvant-induced chronic unilateral arthritis in two mouse strains.
Journal of neuroscience methods 2004;139(2):281-91.
2004: Maria Kukley; Pia Stausberg; Giselind Adelmann; Iain P Chessell; Dirk Dietrich
Ecto-nucleotidases and nucleoside transporters mediate activation of adenosine receptors on hippocampal mossy fibers by P2X7 receptor agonist 2'-3'-O-(4-benzoylbenzoyl)-ATP.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(32):7128-39.
2004: Clare A Jones; Catherine Vial; Lynda A Sellers; Pat P A Humphrey; Richard J Evans; Iain P Chessell
Functional regulation of P2X6 receptors by N-linked glycosylation: identification of a novel alpha beta-methylene ATP-sensitive phenotype.
Molecular pharmacology 2004;65(4):979-85.
2004: Pascal F Durrenberger; Paul Facer; Roy A Gray; Iain P Chessell; Alan Naylor; Chas Bountra; Richard B Banati; Rolfe Birch; Praveen Anand
Cyclooxygenase-2 (Cox-2) in injured human nerve and a rat model of nerve injury.
Journal of the peripheral nervous system : JPNS 2004;9(1):15-25.
2003: Alison Gartland; Katherine A Buckley; Robert A Hipskind; M J Perry; J H Tobias; G Buell; Iain P Chessell; Wayne B Bowler; James A Gallagher
Multinucleated osteoclast formation in vivo and in vitro by P2X7 receptor-deficient mice.
Critical reviews in eukaryotic gene expression 2003;13(2-4):243-53.
2001: Stephan D Gauldie; Daniel S McQueen; R Pertwee; Iain P Chessell
Anandamide activates peripheral nociceptors in normal and arthritic rat knee joints.
British journal of pharmacology 2001;132(3):617-21.
2000: Ben J Gu; W Y Zhang; Linda Bendall; Iain P Chessell; Gary N Buell; James S Wiley
Expression of P2X(7) purinoceptors on human lymphocytes and monocytes: evidence for nonfunctional P2X(7) receptors.
American journal of physiology. Cell physiology 2000;279(4):C1189-97.
2000: Anton D Michel; R Kaur; Iain P Chessell; Patrick P A Humphrey
Antagonist effects on human P2X(7) receptor-mediated cellular accumulation of YO-PRO-1.
British journal of pharmacology 2000;130(3):513-20.
2000: AD Hibell; E J Kidd; Iain P Chessell; Patrick P A Humphrey; Anton D Michel
Apparent species differences in the kinetic properties of P2X(7) receptors.
British journal of pharmacology 2000;130(1):167-73.
2000: C A Jones; Iain P Chessell; J Simon; Eric A Barnard; KJ Miller; Anton D Michel; Patrick P A Humphrey
Functional characterization of the P2X(4) receptor orthologues.
British journal of pharmacology 2000;129(2):388-94.
1999: Caroline B A Grahames; Anton D Michel; Iain P Chessell; Patrick P A Humphrey
Pharmacological characterization of ATP- and LPS-induced IL-1beta release in human monocytes.
British journal of pharmacology 1999;127(8):1915-21.
1999: Anton D Michel; Iain P Chessell; Patrick P A Humphrey
Ionic effects on human recombinant P2X7 receptor function.
Naunyn-Schmiedeberg's archives of pharmacology 1999;359(2):102-9.
1998: KJ Miller; Anton D Michel; Iain P Chessell; Patrick P A Humphrey
Cibacron blue allosterically modulates the rat P2X4 receptor.
Neuropharmacology 1998;37(12):1579-86.
1998: Gary N Buell; Iain P Chessell; Anton D Michel; G Collo; M Salazzo; Suzanne Herren; D Gretener; Caroline B A Grahames; R Kaur; Marie H Kosco-Vilbois; Patrick P A Humphrey
Blockade of human P2X7 receptor function with a monoclonal antibody.
Blood 1998;92(10):3521-8.
1998: Iain P Chessell; Joseph Simon; AD Hibell; Anton D Michel; Eric A Barnard; Patrick P A Humphrey
Cloning and functional characterisation of the mouse P2X7 receptor.
FEBS letters 1998;439(1-2):26-30.
1998: E Dowd; Daniel S McQueen; Iain P Chessell; PP Humphrey
Adenosine A1 receptor-mediated excitation of nociceptive afferents innervating the normal and arthritic rat knee joint.
British journal of pharmacology 1998;125(6):1267-71.
1998: Anton D Michel; Iain P Chessell; AD Hibell; Joseph Simon; Patrick P A Humphrey
Identification and characterization of an endogenous P2X7 (P2Z) receptor in CHO-K1 cells.
British journal of pharmacology 1998;125(6):1194-201.
1998: E Dowd; Daniel S McQueen; Iain P Chessell; PP Humphrey
P2X receptor-mediated excitation of nociceptive afferents in the normal and arthritic rat knee joint.
British journal of pharmacology 1998;125(2):341-6.
1998: A J Sansum; Iain P Chessell; Gareth Hicks; D J Trezise; Patrick P A Humphrey
Evidence that P2X purinoceptors mediate the excitatory effects of alphabetamethylene-ADP in rat locus coeruleus neurones.
Neuropharmacology 1998;37(7):875-85.
1998: Iain P Chessell; Anton D Michel; Patrick P A Humphrey
Effects of antagonists at the human recombinant P2X7 receptor.
British journal of pharmacology 1998;124(6):1314-20.
1998: Daniel S McQueen; Susan M Bond; C Moores; Iain P Chessell; PP Humphrey; E Dowd
Activation of P2X receptors for adenosine triphosphate evokes cardiorespiratory reflexes in anaesthetized rats.
The Journal of physiology 1998;507 ( Pt 3)():843-55.
1997: J Simon; E J Kidd; F M Smith; Iain P Chessell; Ruth D Murrell-Lagnado; Patrick P A Humphrey; Eric A Barnard
Localization and functional expression of splice variants of the P2X2 receptor.
Molecular pharmacology 1997;52(2):237-48.
1997: Iain P Chessell; Anton D Michel; Patrick P A Humphrey
Properties of the pore-forming P2X7 purinoceptor in mouse NTW8 microglial cells.
British journal of pharmacology 1997;121(7):1429-37.
1997: Iain P Chessell; Anton D Michel; Patrick P A Humphrey
Functional evidence for multiple purinoceptor subtypes in the rat medial vestibular nucleus.
Neuroscience 1997;77(3):783-91.
1996: Iain P Chessell; M D Black; Wasyl Feniuk; Patrick P A Humphrey
Operational characteristics of somatostatin receptors mediating inhibitory actions on rat locus coeruleus neurones.
British journal of pharmacology 1996;117(8):1673-8.
1995: Iain P Chessell; Patrick P A Humphrey
Nicotinic and muscarinic receptor-evoked depolarizations recorded from a novel cortical brain slice preparation.
Neuropharmacology 1995;34(10):1289-96.