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John Chiang

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TOP 3
Tiangang Li; John Y L Chiang
Nuclear receptors in bile acid metabolism.
Tiangang Li; John Y L Chiang
Bile Acid signaling in liver metabolism and diseases.
Xuemei Ge; Tiangang Li; Huiyan Ma; Liya Yin; John Y L Chiang; Yanqiao Zhang
Aldo-keto reductase 1B7 is a target gene of FXR and regulates lipid and glucose homeostasis.

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All Publications

2013: Tiangang Li; John Y L Chiang
Nuclear receptors in bile acid metabolism.
Drug metabolism reviews 2013;45(1):145-55.
2012: Tiangang Li; John Y L Chiang
Bile Acid signaling in liver metabolism and diseases.
Journal of lipids 2012;2012():754067.
2011: Xuemei Ge; Tiangang Li; Huiyan Ma; Liya Yin; John Y L Chiang; Yanqiao Zhang
Aldo-keto reductase 1B7 is a target gene of FXR and regulates lipid and glucose homeostasis.
Journal of lipid research 2011;52(8):1561-8.
2011: Tiangang Li; Michelle Matozel; Shannon Boehme; Bo Kong; Lisa-Mari Nilsson; Grace Guo; Ewa Ellis; John Y L Chiang
Overexpression of cholesterol 7α-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis.
Hepatology (Baltimore, Md.) 2011;53(3):996-1006.
2010: Tiangang Li; Erika Owsley; Michelle Matozel; Peter Hsu; Colleen M Novak; John Y L Chiang
Transgenic expression of cholesterol 7alpha-hydroxylase in the liver prevents high-fat diet-induced obesity and insulin resistance in mice.
Hepatology (Baltimore, Md.) 2010;52(2):678-90.
2010: Kwang-Hoon Song; Tiangang Li; Erika Owsley; John Y L Chiang
A putative role of micro RNA in regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes.
Journal of lipid research 2010;51(8):2223-33.
2010: Shuxin Han; Tiangang Li; Ewa Ellis; Stephen Strom; John Y L Chiang
A novel bile acid-activated vitamin D receptor signaling in human hepatocytes.
Molecular endocrinology (Baltimore, Md.) 2010;24(6):1151-64.
2010: Tiangang Li; Dipanjan Chanda; Yanqiao Zhang; Hueng-Sik Choi; John Y L Chiang
Glucose stimulates cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.
Journal of lipid research 2010;51(4):832-42.
2009: Tiangang Li; Huiyan Ma; Young Joo Park; Yoon-Kwang Lee; Stephen Strom; David D Moore; John Y L Chiang
Forkhead box transcription factor O1 inhibits cholesterol 7alpha-hydroxylase in human hepatocytes and in high fat diet-fed mice.
Biochimica et biophysica acta 2009;1791(10):991-6.
2009: John Y L Chiang
Bile acids: regulation of synthesis.
Journal of lipid research 2009;50(10):1955-66.
2009: Shuxin Han; John Y L Chiang
Mechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(3):469-78.
2009: John Y L Chiang
Hepatocyte nuclear factor 4alpha regulation of bile acid and drug metabolism.
Expert opinion on drug metabolism & toxicology 2009;5(2):137-47.
2009: James P Hardwick; John Y L Chiang
PPARs, RXRs, and Drug-Metabolizing Enzymes.
PPAR research 2009;2009():589626.
2009: Tiangang Li; John Y L Chiang
Regulation of bile acid and cholesterol metabolism by PPARs.
PPAR research 2009;2009():501739.
2009: Kwang-Hoon Song; Tiangang Li; Erika Owsley; Stephen Strom; John Y L Chiang
Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression.
Hepatology (Baltimore, Md.) 2009;49(1):297-305.
2008: Tiangang Li; Huiyan Ma; John Y L Chiang
TGFbeta1, TNFalpha, and insulin signaling crosstalk in regulation of the rat cholesterol 7alpha-hydroxylase gene expression.
Journal of lipid research 2008;49(9):1981-9.
2007: Kwang-Hoon Song; Ewa Ellis; Stephen Strom; John Y L Chiang
Hepatocyte growth factor signaling pathway inhibits cholesterol 7alpha-hydroxylase and bile acid synthesis in human hepatocytes.
Hepatology (Baltimore, Md.) 2007;46(6):1993-2002.
2007: Tiangang Li; John Y L Chiang
A novel role of transforming growth factor beta1 in transcriptional repression of human cholesterol 7alpha-hydroxylase gene.
Gastroenterology 2007;133(5):1660-9.
2007: Quan Shang; Luxing Pan; Monica Saumoy; John Y L Chiang; Stephen G Tint; Gerald Salen; Guorong Xu
An overlapping binding site in the CYP7A1 promoter allows activation of FXR to override the stimulation by LXRalpha.
American journal of physiology. Gastrointestinal and liver physiology 2007;293(4):G817-23.
2007: Tiangang Li; Wenling Chen; John Y L Chiang
PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine.
Journal of lipid research 2007;48(2):373-84.
2006: Tiangang Li; Xiaoying Kong; Erika Owsley; Ewa Ellis; Stephen Strom; John Y L Chiang
Insulin regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes: roles of forkhead box O1 and sterol regulatory element-binding protein 1c.
The Journal of biological chemistry 2006;281(39):28745-54.
2006: Wanjin Tang; Gösta Eggertsen; John Y L Chiang; Maria Norlin
Estrogen-mediated regulation of CYP7B1: a possible role for controlling DHEA levels in human tissues.
The Journal of steroid biochemistry and molecular biology 2006;100(1-3):42-51.
2006: Tiangang Li; Asmeen Jahan; John Y L Chiang
Bile acids and cytokines inhibit the human cholesterol 7 alpha-hydroxylase gene via the JNK/c-jun pathway in human liver cells.
Hepatology (Baltimore, Md.) 2006;43(6):1202-10.
2006: Quan Shang; Luxing Pan; Monica Saumoy; John Y L Chiang; Stephen G Tint; Gerald Salen; Guorong Xu
The stimulatory effect of LXRalpha is blocked by SHP despite the presence of a LXRalpha binding site in the rabbit CYP7A1 promoter.
Journal of lipid research 2006;47(5):997-1004.
2006: Tiangang Li; John Y L Chiang
Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(5):756-64.
2006: Kwang-Hoon Song; Tiangang Li; John Y L Chiang
A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene.
The Journal of biological chemistry 2006;281(15):10081-8.
2006: Kwang-Hoon Song; John Y L Chiang
Glucagon and cAMP inhibit cholesterol 7alpha-hydroxylase (CYP7A1) gene expression in human hepatocytes: discordant regulation of bile acid synthesis and gluconeogenesis.
Hepatology (Baltimore, Md.) 2006;43(1):117-25.
2005: John Y L Chiang
Nuclear receptor regulation of lipid metabolism: potential therapeutics for dyslipidemia, diabetes, and chronic heart and liver diseases.
Current opinion in investigational drugs (London, England : 2000) 2005;6(10):994-1001.
2005: Asmeen Jahan; John Y L Chiang
Cytokine regulation of human sterol 12alpha-hydroxylase (CYP8B1) gene.
American journal of physiology. Gastrointestinal and liver physiology 2005;288(4):G685-95.
2005: Hai Li; Frank Chen; Quan Shang; Luxing Pan; Benjamin L Shneider; John Y L Chiang; Barry M Forman; Meenakshisundaram Ananthanarayanan; Stephen G Tint; Gerald Salen; Guorong Xu
FXR-activating ligands inhibit rabbit ASBT expression via FXR-SHP-FTF cascade.
American journal of physiology. Gastrointestinal and liver physiology 2005;288(1):G60-6.
2005: Tiangang Li; John Y L Chiang
Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7 alpha-hydroxylase gene transcription.
American journal of physiology. Gastrointestinal and liver physiology 2005;288(1):G74-84.
2004: Yizeng Yang; Gösta Eggertsen; Mats Gåfvels; Ulla Andersson; Curt Einarsson; Ingemar Björkhem; John Y L Chiang
Mechanisms of cholesterol and sterol regulatory element binding protein regulation of the sterol 12alpha-hydroxylase gene (CYP8B1).
Biochemical and biophysical research communications 2004;320(4):1204-10.
2004: David S Riddick; Chunja Lee; Anahita Bhathena; Yoav E Timsit; Po-Yung Cheng; Edward T Morgan; Russell A Prough; Sharon L Ripp; Kristy K Michael Miller; Asmeen Jahan; John Y L Chiang
Transcriptional suppression of cytochrome P450 genes by endogenous and exogenous chemicals.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(4):367-75.
2004: Maria Norlin; John Y L Chiang
Transcriptional regulation of human oxysterol 7alpha-hydroxylase by sterol response element binding protein.
Biochemical and biophysical research communications 2004;316(1):158-64.
2004: John Y L Chiang
Regulation of bile acid synthesis: pathways, nuclear receptors, and mechanisms.
Journal of hepatology 2004;40(3):539-51.
2003: Wenling Chen; John Y L Chiang
Regulation of human sterol 27-hydroxylase gene (CYP27A1) by bile acids and hepatocyte nuclear factor 4alpha (HNF4alpha).
Gene 2003;313():71-82.
2003: Erika Owsley; John Y L Chiang
Guggulsterone antagonizes farnesoid X receptor induction of bile salt export pump but activates pregnane X receptor to inhibit cholesterol 7alpha-hydroxylase gene.
Biochemical and biophysical research communications 2003;304(1):191-5.
2003: John Y L Chiang
Bile acid regulation of hepatic physiology: III. Bile acids and nuclear receptors.
American journal of physiology. Gastrointestinal and liver physiology 2003;284(3):G349-56.
2002: John Y L Chiang
Bile acid regulation of gene expression: roles of nuclear hormone receptors.
Endocrine reviews 2002;23(4):443-63.
2002: Yizeng Yang; Ming Zhang; Gösta Eggertsen; John Y L Chiang
On the mechanism of bile acid inhibition of rat sterol 12alpha-hydroxylase gene (CYP8B1) transcription: roles of alpha-fetoprotein transcription factor and hepatocyte nuclear factor 4alpha.
Biochimica et biophysica acta 2002;1583(1):63-73.
2001: M Zhang; John Y L Chiang
Transcriptional regulation of the human sterol 12alpha-hydroxylase gene (CYP8B1): roles of heaptocyte nuclear factor 4alpha in mediating bile acid repression.
The Journal of biological chemistry 2001;276(45):41690-9.
2001: Wenling Chen; Erika Owsley; Y Yang; D Stroup; John Y L Chiang
Nuclear receptor-mediated repression of human cholesterol 7alpha-hydroxylase gene transcription by bile acids.
Journal of lipid research 2001;42(9):1402-12.
2001: Z Wu; John Y L Chiang
Transcriptional regulation of human oxysterol 7 alpha-hydroxylase gene (CYP7B1) by Sp1.
Gene 2001;272(1-2):191-7.
2001: John Y L Chiang; R Kimmel; D Stroup
Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha).
Gene 2001;262(1-2):257-65.
2000: John Y L Chiang; R Kimmel; C Weinberger; D Stroup
Farnesoid X receptor responds to bile acids and represses cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription.
The Journal of biological chemistry 2000;275(15):10918-24.
2000: M Marrapodi; John Y L Chiang
Peroxisome proliferator-activated receptor alpha (PPARalpha) and agonist inhibit cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription.
Journal of lipid research 2000;41(4):514-20.
2000: D Stroup; John Y L Chiang
HNF4 and COUP-TFII interact to modulate transcription of the cholesterol 7alpha-hydroxylase gene (CYP7A1).
Journal of lipid research 2000;41(1):1-11.
1999: Z Wu; KO Martin; Norman B Javitt; John Y L Chiang
Structure and functions of human oxysterol 7alpha-hydroxylase cDNAs and gene CYP7B1.
Journal of lipid research 1999;40(12):2195-203.
1998: D Foti; D Stroup; John Y L Chiang
Basic transcription element binding protein (BTEB) transactivates the cholesterol 7 alpha-hydroxylase gene (CYP7A).
Biochemical and biophysical research communications 1998;253(1):109-13.
1998: M Crestani; A Sadeghpour; D Stroup; G Galli; John Y L Chiang
Transcriptional activation of the cholesterol 7alpha-hydroxylase gene (CYP7A) by nuclear hormone receptors.
Journal of lipid research 1998;39(11):2192-200.
1998: John Y L Chiang
Regulation of bile acid synthesis.
Frontiers in bioscience : a journal and virtual library 1998;3():d176-93.
1997: D Stroup; M Crestani; John Y L Chiang
Identification of a bile acid response element in the cholesterol 7 alpha-hydroxylase gene CYP7A.
The American journal of physiology 1997;273(2 Pt 1):G508-17.
1997: D Stroup; M Crestani; John Y L Chiang
Orphan receptors chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) and retinoid X receptor (RXR) activate and bind the rat cholesterol 7alpha-hydroxylase gene (CYP7A).
The Journal of biological chemistry 1997;272(15):9833-9.
1996: Emma De Fabiani; M Crestani; M Marrapodi; A Pinelli; John Y L Chiang; Giovanni Galli
Regulation of the hamster cholesterol 7 alpha-hydroxylase gene (CYP7A): prevalence of negative over positive transcriptional control.
Biochemical and biophysical research communications 1996;226(3):663-71.
1996: D P Wang; D Stroup; M Marrapodi; M Crestani; Giovanni Galli; John Y L Chiang
Transcriptional regulation of the human cholesterol 7 alpha-hydroxylase gene (CYP7A) in HepG2 cells.
Journal of lipid research 1996;37(9):1831-41.
1996: M Crestani; A Sadeghpour; D Stroup; Giovanni Galli; John Y L Chiang
The opposing effects of retinoic acid and phorbol esters converge to a common response element in the promoter of the rat cholesterol 7 alpha-hydroxylase gene (CYP7A).
Biochemical and biophysical research communications 1996;225(2):585-92.
1996: William M Pandak; R Todd Stravitz; V Lucas; Douglas M Heuman; John Y L Chiang
Hep G2 cells: a model for studies on regulation of human cholesterol 7alpha-hydroxylase at the molecular level.
The American journal of physiology 1996;270(3 Pt 1):G401-10.
1995: M Crestani; D Stroup; John Y L Chiang
Hormonal regulation of the cholesterol 7 alpha-hydroxylase gene (CYP7).
Journal of lipid research 1995;36(11):2419-32.
1995: William M Pandak; Douglas M Heuman; Phillip B Hylemon; John Y L Chiang; Z Reno Vlahcevic
Failure of intravenous infusion of taurocholate to down-regulate cholesterol 7 alpha-hydroxylase in rats with biliary fistulas.
Gastroenterology 1995;108(2):533-44.
1994: John Y L Chiang; D Stroup
Identification and characterization of a putative bile acid-responsive element in cholesterol 7 alpha-hydroxylase gene promoter.
The Journal of biological chemistry 1994;269(26):17502-7.
1994: W G Karam; John Y L Chiang
Expression and purification of human cholesterol 7 alpha-hydroxylase in Escherichia coli.
Journal of lipid research 1994;35(7):1222-31.
1994: William M Pandak; Z Reno Vlahcevic; Douglas M Heuman; K S Redford; John Y L Chiang; Phillip B Hylemon
Effects of different bile salts on steady-state mRNA levels and transcriptional activity of cholesterol 7 alpha-hydroxylase.
Hepatology (Baltimore, Md.) 1994;19(4):941-7.
1994: D P Wang; John Y L Chiang
Structure and nucleotide sequences of the human cholesterol 7 alpha-hydroxylase gene (CYP7).
Genomics 1994;20(2):320-3.
1994: M Crestani; W G Karam; John Y L Chiang
Effects of bile acids and steroid/thyroid hormones on the expression of cholesterol 7 alpha-hydroxylase mRNA and the CYP7 gene in HepG2 cells.
Biochemical and biophysical research communications 1994;198(2):546-53.
1993: M Crestani; Giovanni Galli; John Y L Chiang
Genomic cloning, sequencing, and analysis of the hamster cholesterol 7 alpha-hydroxylase gene (CYP7).
Archives of biochemistry and biophysics 1993;306(2):451-60.
1993: M P Jones; William M Pandak; Douglas M Heuman; John Y L Chiang; P B Hylemon; Z Reno Vlahcevic
Cholesterol 7 alpha-hydroxylase: evidence for transcriptional regulation by cholesterol or metabolic products of cholesterol in the rat.
Journal of lipid research 1993;34(6):885-92.
1992: John Y L Chiang; T P Yang; D P Wang
Cloning and 5'-flanking sequence of a rat cholesterol 7 alpha-hydroxylase gene.
Biochimica et biophysica acta 1992;1132(3):337-9.
1992: Phillip B Hylemon; E C Gurley; R Todd Stravitz; Julie Litz; William M Pandak; John Y L Chiang; Z Reno Vlahcevic
Hormonal regulation of cholesterol 7 alpha-hydroxylase mRNA levels and transcriptional activity in primary rat hepatocyte cultures.
The Journal of biological chemistry 1992;267(24):16866-71.
1992: W G Karam; John Y L Chiang
Polymorphisms of human cholesterol 7 alpha-hydroxylase.
Biochemical and biophysical research communications 1992;185(2):588-95.
1992: William M Pandak; Z Reno Vlahcevic; John Y L Chiang; Douglas M Heuman; Phillip B Hylemon
Bile acid synthesis. VI. Regulation of cholesterol 7 alpha-hydroxylase by taurocholate and mevalonate.
Journal of lipid research 1992;33(5):659-68.
1991: Y C Li; John Y L Chiang
The expression of a catalytically active cholesterol 7 alpha-hydroxylase cytochrome P450 in Escherichia coli.
The Journal of biological chemistry 1991;266(29):19186-91.
1991: William M Pandak; Y C Li; John Y L Chiang; Elaine Studer; E C Gurley; Douglas M Heuman; Z Reno Vlahcevic; Phillip B Hylemon
Regulation of cholesterol 7 alpha-hydroxylase mRNA and transcriptional activity by taurocholate and cholesterol in the chronic biliary diverted rat.
The Journal of biological chemistry 1991;266(6):3416-21.
1990: Thung Lai; John Y L Chiang
Cloning and characterization of two major 3-methylcholanthrene inducible hamster liver cytochrome P450s.
Archives of biochemistry and biophysics 1990;283(2):429-39.
1990: Gene C Ness; L C Pendleton; Y C Li; John Y L Chiang
Effect of thyroid hormone on hepatic cholesterol 7 alpha hydroxylase, LDL receptor, HMG-CoA reductase, farnesyl pyrophosphate synthetase and apolipoprotein A-I mRNA levels in hypophysectomized rats.
Biochemical and biophysical research communications 1990;172(3):1150-6.
1990: Y C Li; D P Wang; John Y L Chiang
Regulation of cholesterol 7 alpha-hydroxylase in the liver. Cloning, sequencing, and regulation of cholesterol 7 alpha-hydroxylase mRNA.
The Journal of biological chemistry 1990;265(20):12012-9.
1990: John Y L Chiang; W F Miller; G M Lin
Regulation of cholesterol 7 alpha-hydroxylase in the liver. Purification of cholesterol 7 alpha-hydroxylase and the immunochemical evidence for the induction of cholesterol 7 alpha-hydroxylase by cholestyramine and circadian rhythm.
The Journal of biological chemistry 1990;265(7):3889-97.
1990: Thung Lai; John Y L Chiang
Aflatoxin B1 metabolism by 3-methylcholanthrene-induced hamster hepatic cytochrome P-450s.
Journal of biochemical toxicology 1990;5(3):147-53.
1989: Phillip B Hylemon; Elaine Studer; William M Pandak; Douglas M Heuman; Z Reno Vlahcevic; John Y L Chiang
Simultaneous measurement of cholesterol 7 alpha-hydroxylase activity by reverse-phase high-performance liquid chromatography using both endogenous and exogenous [4-14C]cholesterol as substrate.
Analytical biochemistry 1989;182(2):212-6.
1988: P M Tang; J A Finkelstein; John Y L Chiang
Expression of hepatic microsomal cholesterol 7 alpha-hydroxylase activity in lean and obese Zucker rats.
Biochemical and biophysical research communications 1988;150(2):853-8.
1986: P M Tang; John Y L Chiang
Modulation of reconstituted cholesterol 7 alpha-hydroxylase by phosphatase and protein kinase.
Biochemical and biophysical research communications 1986;134(2):797-802.
1985: John Y L Chiang; C W Fisher; A Steggles; P M Tang
Hamster hepatic cytochrome b5: purifications, immunochemical properties, and in vitro synthesis.
Biochimica et biophysica acta 1985;830(1):11-9.