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David Chiara

Research Profile

Chemicals & Drugs

Living Beings

Torpedo

Genes & Molecular Sequences

Amino Acid Sequences

Concepts & Ideas

Physiology

Binding, Competitive

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Publications

TOP 3
Pavel Y Savechenkov; Deirdre S Stewart; Xi Zhang; Xiaojuan Zhou; David C Chiara; Jonathan B Cohen; Stuart A Forman; Rile Ge; Keith W Miller; Douglas Raines; Karol S Bruzik
Allyl m-trifluoromethyldiazirine mephobarbital: an unusually potent enantioselective and photoreactive barbiturate general anesthetic.
David C Chiara; Zuzana Dostalova; Selwyn S Jayakar; Keith W Miller; Xiaojuan Zhou; Jonathan B Cohen
Mapping general anesthetic binding site(s) in human α1β3 γ-aminobutyric acid type A receptors with [³H]TDBzl-etomidate, a photoreactive etomidate analogue.
Deirdre S Stewart; Douglas Raines; Pavel Yuryevich Savechenkov; Karol S Bruzik; David C Chiara; Jonathan B Cohen; Zuzana Dostalova; Stuart A Forman; Rile Ge; Keith W Miller
p-(4-Azipentyl)propofol: a potent photoreactive general anesthetic derivative of propofol.

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All Publications

2012: Pavel Y Savechenkov; Deirdre S Stewart; Xi Zhang; Xiaojuan Zhou; David C Chiara; Jonathan B Cohen; Stuart A Forman; Rile Ge; Keith W Miller; Douglas Raines; Karol S Bruzik
Allyl m-trifluoromethyldiazirine mephobarbital: an unusually potent enantioselective and photoreactive barbiturate general anesthetic.
Journal of medicinal chemistry 2012;55(14):6554-65.
2012: David C Chiara; Zuzana Dostalova; Selwyn S Jayakar; Keith W Miller; Xiaojuan Zhou; Jonathan B Cohen
Mapping general anesthetic binding site(s) in human α1β3 γ-aminobutyric acid type A receptors with [³H]TDBzl-etomidate, a photoreactive etomidate analogue.
Biochemistry 2012;51(4):836-47.
2011: Deirdre S Stewart; Douglas Raines; Pavel Yuryevich Savechenkov; Karol S Bruzik; David C Chiara; Jonathan B Cohen; Zuzana Dostalova; Stuart A Forman; Rile Ge; Keith W Miller
p-(4-Azipentyl)propofol: a potent photoreactive general anesthetic derivative of propofol.
Journal of medicinal chemistry 2011;54(23):8124-35.
2010: Guo-Dong Li; David C Chiara; Jonathan B Cohen; Richard W Olsen
Numerous classes of general anesthetics inhibit etomidate binding to gamma-aminobutyric acid type A (GABAA) receptors.
The Journal of biological chemistry 2010;285(12):8615-20.
2010: Innocent H Yamodo; David C Chiara; Jonathan B Cohen; Keith W Miller
Conformational changes in the nicotinic acetylcholine receptor during gating and desensitization.
Biochemistry 2010;49(1):156-65.
2009: David C Chiara; Ayman K Hamouda; Michael R Ziebell; Luis A Mejia; Galo Garcia; jonathan cohen
[(3)H]chlorpromazine photolabeling of the torpedo nicotinic acetylcholine receptor identifies two state-dependent binding sites in the ion channel.
Biochemistry 2009;48(42):10066-77.
2009: Guo-Dong Li; David C Chiara; jonathan cohen; Richard W Olsen
Neurosteroids allosterically modulate binding of the anesthetic etomidate to gamma-aminobutyric acid type A receptors.
The Journal of biological chemistry 2009;284(18):11771-5.
2009: David C Chiara; Filbert H Hong; Enrique Arevalo; S Shaukat Husain; Keith W Miller; Stuart A Forman; jonathan cohen
Time-resolved photolabeling of the nicotinic acetylcholine receptor by [3H]azietomidate, an open-state inhibitor.
Molecular pharmacology 2009;75(5):1084-95.
2008: Selvanayagam Nirthanan; Galo Garcia; David C Chiara; S Shaukat Husain; jonathan cohen
Identification of binding sites in the nicotinic acetylcholine receptor for TDBzl-etomidate, a photoreactive positive allosteric effector.
The Journal of biological chemistry 2008;283(32):22051-62.
2007: Ayman K Hamouda; Mitesh Sanghvi; David C Chiara; jonathan cohen; Michael P Blanton
Identifying the lipid-protein interface of the alpha4beta2 neuronal nicotinic acetylcholine receptor: hydrophobic photolabeling studies with 3-(trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine.
Biochemistry 2007;46(48):13837-46.
2007: Galo Garcia; David C Chiara; Selvanayagam Nirthanan; Ayman K Hamouda; Deirdre S Stewart; jonathan cohen
[3H]Benzophenone photolabeling identifies state-dependent changes in nicotinic acetylcholine receptor structure.
Biochemistry 2007;46(36):10296-307.
2006: Guo-Dong Li; David C Chiara; Gregory W Sawyer; S Shaukat Husain; Richard W Olsen; jonathan cohen
Identification of a GABAA receptor anesthetic binding site at subunit interfaces by photolabeling with an etomidate analog.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(45):11599-605.
2006: Deirdre S Stewart; David C Chiara; jonathan cohen
Mapping the structural requirements for nicotinic acetylcholine receptor activation by using tethered alkyltrimethylammonium agonists and antagonists.
Biochemistry 2006;45(35):10641-53.
2006: Igor E Kasheverov; David C Chiara; Maxim N Zhmak; Innokentiy Maslennikov; Vladimir S Pashkov; Alexander S Arseniev; Yuri N Utkin; jonathan cohen; Victor I Tsetlin
alpha-Conotoxin GI benzoylphenylalanine derivatives. (1)H-NMR structures and photoaffinity labeling of the Torpedo californica nicotinic acetylcholine receptor.
The FEBS journal 2006;273(7):1373-88.
2006: Ayman K Hamouda; David C Chiara; Daniel Sauls; jonathan cohen; Michael P Blanton
Cholesterol interacts with transmembrane alpha-helices M1, M3, and M4 of the Torpedo nicotinic acetylcholine receptor: photolabeling studies using [3H]Azicholesterol.
Biochemistry 2006;45(3):976-86.
2005: Selvanayagam Nirthanan; Michael R Ziebell; David C Chiara; Filbert Hong; jonathan cohen
Photolabeling the Torpedo nicotinic acetylcholine receptor with 4-azido-2,3,5,6-tetrafluorobenzoylcholine, a partial agonist.
Biochemistry 2005;44(41):13447-56.
2005: Enrique Arevalo; David C Chiara; Stuart A Forman; jonathan cohen; Keith W Miller
Gating-enhanced accessibility of hydrophobic sites within the transmembrane region of the nicotinic acetylcholine receptor's {delta}-subunit. A time-resolved photolabeling study.
The Journal of biological chemistry 2005;280(14):13631-40.
2003: David C Chiara; Lawrence J Dangott; Roderic G Eckenhoff; jonathan cohen
Identification of nicotinic acetylcholine receptor amino acids photolabeled by the volatile anesthetic halothane.
Biochemistry 2003;42(46):13457-67.
2003: David C Chiara; Jonathan C Trinidad; Dong Wang; Michael R Ziebell; Deirdre Sullivan; jonathan cohen
Identification of amino acids in the nicotinic acetylcholine receptor agonist binding site and ion channel photolabeled by 4-[(3-trifluoromethyl)-3H-diazirin-3-yl]benzoylcholine, a novel photoaffinity antagonist.
Biochemistry 2003;42(2):271-83.
2002: Gregory W Sawyer; David C Chiara; Richard W Olsen; jonathan cohen
Identification of the bovine gamma-aminobutyric acid type A receptor alpha subunit residues photolabeled by the imidazobenzodiazepine [3H]Ro15-4513.
The Journal of biological chemistry 2002;277(51):50036-45.
2002: Deirdre Sullivan; David C Chiara; jonathan cohen
Mapping the agonist binding site of the nicotinic acetylcholine receptor by cysteine scanning mutagenesis: antagonist footprint and secondary structure prediction.
Molecular pharmacology 2002;61(2):463-72.
2001: M J Gallagher; David C Chiara; jonathan cohen
Interactions between 3-(Trifluoromethyl)-3-(m-[(125)I]iodophenyl)diazirine and tetracaine, phencyclidine, or histrionicotoxin in the Torpedo series nicotinic acetylcholine receptor ion channel.
Molecular pharmacology 2001;59(6):1514-22.
2001: David C Chiara; Marek A Kloczewiak; George H Addona; J A Yu; jonathan cohen; Keith W Miller
Site of resting state inhibition of the nicotinic acetylcholine receptor by a hydrophobic inhibitor.
Biochemistry 2001;40(1):296-304.
2000: D Wang; David C Chiara; Y Xie; jonathan cohen
Probing the structure of the nicotinic acetylcholine receptor with 4-benzoylbenzoylcholine, a novel photoaffinity competitive antagonist.
The Journal of biological chemistry 2000;275(37):28666-74.
1999: David C Chiara; Y Xie; jonathan cohen
Structure of the agonist-binding sites of the Torpedo nicotinic acetylcholine receptor: affinity-labeling and mutational analyses identify gamma Tyr-111/delta Arg-113 as antagonist affinity determinants.
Biochemistry 1999;38(20):6689-98.
1998: David C Chiara; R E Middleton; jonathan cohen
Identification of tryptophan 55 as the primary site of [3H]nicotine photoincorporation in the gamma-subunit of the Torpedo nicotinic acetylcholine receptor.
FEBS letters 1998;423(2):223-6.
1997: David C Chiara; jonathan cohen
Identification of amino acids contributing to high and low affinity d-tubocurarine sites in the Torpedo nicotinic acetylcholine receptor.
The Journal of biological chemistry 1997;272(52):32940-50.
1994: E Salih; S B Chishti; P Vicedomine; S G Cohen; David C Chiara; jonathan cohen
Active-site peptides of acetylcholinesterase of Electrophorus electricus: labelling of His-440 by 1-bromo-[2-14C]pinacolone and Ser-200 by tritiated diisopropyl fluorophosphate.
Biochimica et biophysica acta 1994;1208(2):324-31.