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Ramon Alemany
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Living Beings
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Network (preview)
18
Curiel, David
15
Fueyo, Juan
14
Gomez-Manzano, Candelaria
12
Cascallo, Manel
11
Yung, Alfred
8
Jiang, Hong
7
Alonso, Marta
5
Fillat, Cristina
5
Gerritsen, Winald
5
van Beusechem, Victor
5
Roth, Jack
4
Bekele, Nebiyou
4
Balagué, Cristina
4
Kyritsis, Athanassios
4
Lang, Frederick
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Geonetwork of Ramon Alemany (preview)
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All Publications
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2009: Martinez-Quintanilla Jordi; Cascallo Manel; Gros Alena; Fillat Cristina; Alemany Ramon
Positive selection of gene-modified cells increases the efficacy of pancreatic cancer suicide gene therapy.
Molecular cancer therapeutics 2009;8(11):3098-107.
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2009: Bayo-Puxan Neus; Gimenez-Alejandre Marta; Lavilla-Alonso Sergio; Gros Alena; Cascallo Manel; Hemminki Akseli; Alemany Ramon
Replacement of adenovirus type 5 fiber shaft heparan sulfate proteoglycan-binding domain with RGD for improved tumor infectivity and targeting.
Human gene therapy 2009;20(10):1214-21.
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2009: Martinez-Quintanilla Jordi; Cascallo Manel; Fillat Cristina; Alemany Ramon
Antitumor therapy based on cellular competition.
Human gene therapy 2009;20(7):728-38.
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2009: Alemany Ramon; Cascallo Manel
Oncolytic viruses from the perspective of the immune system.
Future microbiology 2009;4():527-36.
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2009: Huch Meritxell; Gros Alena; José Anabel; González Juan Ramon; Alemany Ramon; Fillat Cristina
Urokinase-type plasminogen activator receptor transcriptionally controlled adenoviruses eradicate pancreatic tumors and liver metastasis in mouse models.
Neoplasia (New York, N.Y.) 2009;11(6):518-28, 4 p following 528.
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2009: Piao Y; Jiang H; Alemany R; Krasnykh V; Marini F C; Xu J; Alonso M M; Conrad C A; Aldape K D; Gomez-Manzano C; Fueyo J
Oncolytic adenovirus retargeted to Delta-EGFR induces selective antiglioma activity.
Cancer gene therapy 2009;16(3):256-65.
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2008: Gimenez-Alejandre Marta; Cascallo Manel; Bayo-Puxan Neus; Alemany Ramon
Coagulation factors determine tumor transduction in vivo.
Human gene therapy 2008;19(12):1415-9.
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2008: Gros Alena; Martínez-Quintanilla Jordi; Puig Cristina; Guedan Sonia; Molleví David G; Alemany Ramon; Cascallo Manel
Bioselection of a gain of function mutation that enhances adenovirus 5 release and improves its antitumoral potency.
Cancer research 2008;68(21):8928-37.
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2008: Guedan S; Gros A; Cascallo M; Vile R; Mercade E; Alemany R
Syncytia formation affects the yield and cytotoxicity of an adenovirus expressing a fusogenic glycoprotein at a late stage of replication.
Gene therapy 2008;15(17):1240-5.
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2008: Alonso Marta M; Alemany Ramon; Fueyo Juan; Gomez-Manzano Candelaria
E2F1 in gliomas: a paradigm of oncogene addiction.
Cancer letters 2008;263(2):157-63.
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2007: Cascante A; Abate-Daga D; Garcia-Rodríguez L; González J R; Alemany R; Fillat C
GCV modulates the antitumoural efficacy of a replicative adenovirus expressing the Tat8-TK as a late gene in a pancreatic tumour model.
Gene therapy 2007;14(20):1471-80.
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2007: Alonso Marta M; Cascallo Manel; Gomez-Manzano Candelaria; Jiang Hong; Bekele B Nebiyou; Perez-Gimenez Anna; Lang Frederick F; Piao Yuji; Alemany Ramon; Fueyo Juan
ICOVIR-5 shows E2F1 addiction and potent antiglioma effect in vivo.
Cancer research 2007;67(17):8255-63.
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2007: Cascallo Manel; Alonso Marta M; Rojas Juan J; Perez-Gimenez Anna; Fueyo Juan; Alemany Ramon
Systemic toxicity-efficacy profile of ICOVIR-5, a potent and selective oncolytic adenovirus based on the pRB pathway.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(9):1607-15.
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2007: Alonso M M; Gomez-Manzano C; Jiang H; Bekele N B; Piao Y; Yung W K A; Alemany R; Fueyo J
Combination of the oncolytic adenovirus ICOVIR-5 with chemotherapy provides enhanced anti-glioma effect in vivo.
Cancer gene therapy 2007;14(8):756-61.
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2006: Cascallo Manel; Gros Alena; Bayo Neus; Serrano Teresa; Capella Gabriel; Alemany Ramon
Deletion of VAI and VAII RNA genes in the design of oncolytic adenoviruses.
Human gene therapy 2006;17(9):929-40.
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2006: Bayo-Puxan Neus; Cascallo Manel; Gros Alena; Huch Meritxell; Fillat Cristina; Alemany Ramon
Role of the putative heparan sulfate glycosaminoglycan-binding site of the adenovirus type 5 fiber shaft on liver detargeting and knob-mediated retargeting.
The Journal of general virology 2006;87(Pt 9):2487-95.
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2006: Majem M; Cascallo M; Bayo-Puxan N; Mesia R; Germa J R; Alemany R
Control of E1A under an E2F-1 promoter insulated with the myotonic dystrophy locus insulator reduces the toxicity of oncolytic adenovirus Ad-Delta24RGD.
Cancer gene therapy 2006;13(7):696-705.
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2006: Gomez-Manzano Candelaria; Alonso Marta M; Yung W K Alfred; McCormick Frank; Curiel David T; Lang Frederick F; Jiang Hong; Bekele B Nebiyou; Zhou Xian; Alemany Ramon; Fueyo Juan
Delta-24 increases the expression and activity of topoisomerase I and enhances the antiglioma effect of irinotecan.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(2):556-62.
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2005: Heideman Daniëlle A M; Steenbergen Renske D M; van der Torre Jaco; Scheffner Martin; Alemany Ramon; Gerritsen Winald R; Meijer Chris J L M; Snijders Peter J F; van Beusechem Victor W
Oncolytic adenovirus expressing a p53 variant resistant to degradation by HPV E6 protein exhibits potent and selective replication in cervical cancer.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(6):1083-90.
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2005: Jiang Hong; Alemany Ramon; Gomez-Manzano Candelaria; Medrano Diana R; Lemoine Michael G; Olson Melissa V; Alonso Marta M; Lee Ok-Hee; Conrad Charles C; Yung W K Alfred; Fueyo Juan
Downmodulation of E1A protein expression as a novel strategy to design cancer-selective adenoviruses.
Neoplasia (New York, N.Y.) 2005;7(8):723-9.
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2005: Jiang Hong; Gomez-Manzano Candelaria; Alemany Ramon; Medrano Diana; Alonso Marta; Bekele B Nebiyou; Lin E; Conrad Charles C; Yung W K Alfred; Fueyo Juan
Comparative effect of oncolytic adenoviruses with E1A-55 kDa or E1B-55 kDa deletions in malignant gliomas.
Neoplasia (New York, N.Y.) 2005;7(1):48-56.
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2005: Grill Jacques; Lamfers Martine L M; van Beusechem Victor W; van der Valk Paul; Huisman Anne; Sminia Peter; Alemany Ramon; Curiel David T; Vandertop W Peter; Gerritsen Winald R; Dirven Clemens M F
Oncolytic virotherapy of meningiomas in vitro with replication-competent adenovirus.
Neurosurgery 2005;56(1):146-53; discussion 153-4.
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2004: Gomez-Manzano Candelaria; Yung W K Alfred; Alemany Ramon; Fueyo Juan
Genetically modified adenoviruses against gliomas: from bench to bedside.
Neurology 2004;63(3):418-26.
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2004: Carette Jan E; Overmeer Renée M; Schagen Frederik H E; Alemany Ramon; Barski Oleg A; Gerritsen Winald R; Van Beusechem Victor W
Conditionally replicating adenoviruses expressing short hairpin RNAs silence the expression of a target gene in cancer cells.
Cancer research 2004;64(8):2663-7.
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2004: Gomez-Manzano Candelaria; Balague Cristina; Alemany Ramon; Lemoine Michael G; Mitlianga Paraskevi; Jiang Hong; Khan Asadullah; Alonso Marta; Lang Frederick F; Conrad Charles A; Liu Ta-Jen; Bekele B Nebiyou; Yung W K Alfred; Fueyo Juan
A novel E1A-E1B mutant adenovirus induces glioma regression in vivo.
Oncogene 2004;23(10):1821-8.
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2004: Witlox Adhiambo M; Van Beusechem Victor W; Molenaar Bonnie; Bras Hans; Schaap Gerard R; Alemany Ramon; Curiel David T; Pinedo Herbert M; Wuisman Paul I J M; Gerritsen Winald R
Conditionally replicative adenovirus with tropism expanded towards integrins inhibits osteosarcoma tumor growth in vitro and in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(1 Pt 1):61-7.
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2004: Nettelbeck Dirk M; Rivera Angel A; Kupsch Jörg; Dieckmann Detlef; Douglas Joanne T; Kontermann Roland E; Alemany Ramon; Curiel David T
Retargeting of adenoviral infection to melanoma: combining genetic ablation of native tropism with a recombinant bispecific single-chain diabody (scDb) adapter that binds to fiber knob and HMWMAA.
International journal of cancer. Journal international du cancer 2004;108(1):136-45.
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2004: Cascalló Manel; Alemany Ramon
Adenovirus-mediated gene transfer to tumor cells.
Methods in molecular biology (Clifton, N.J.) 2004;246():121-38.
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2003: Cascalló Manel; Capellà Gabriel; Mazo Adela; Alemany Ramon
Ras-dependent oncolysis with an adenovirus VAI mutant.
Cancer research 2003;63(17):5544-50.
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2003: Fueyo Juan; Alemany Ramon; Gomez-Manzano Candelaria; Fuller Gregory N; Khan Asadullah; Conrad Charles A; Liu Ta-Jen; Jiang Hong; Lemoine Michael G; Suzuki Kaori; Sawaya Raymond; Curiel David T; Yung W K Alfred; Lang Frederick F
Preclinical characterization of the antiglioma activity of a tropism-enhanced adenovirus targeted to the retinoblastoma pathway.
Journal of the National Cancer Institute 2003;95(9):652-60.
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2003: Yamamoto Masato; Davydova Julia; Takayama Koichi; Alemany Ramon; Curiel David T
Transcription initiation activity of adenovirus left-end sequence in adenovirus vectors with e1 deleted.
Journal of virology 2003;77(2):1633-7.
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2002: Suzuki Kaori; Alemany Ramón; Yamamoto Masato; Curiel David T
The presence of the adenovirus E3 region improves the oncolytic potency of conditionally replicative adenoviruses.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(11):3348-59.
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2002: Lamfers Martine L M; Grill Jacques; Dirven Clemens M F; Van Beusechem Victor W; Geoerger Birgit; Van Den Berg Jaap; Alemany Ramon; Fueyo Juan; Curiel David T; Vassal Gilles; Pinedo Herbert M; Vandertop W Peter; Gerritsen Winald R
Potential of the conditionally replicative adenovirus Ad5-Delta24RGD in the treatment of malignant gliomas and its enhanced effect with radiotherapy.
Cancer research 2002;62(20):5736-42.
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2002: Nettelbeck Dirk M; Rivera Angel A; Balagué Cristina; Alemany Ramon; Curiel David T
Novel oncolytic adenoviruses targeted to melanoma: specific viral replication and cytolysis by expression of E1A mutants from the tyrosinase enhancer/promoter.
Cancer research 2002;62(16):4663-70.
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2002: Bauerschmitz Gerd J; Lam John T; Kanerva Anna; Suzuki Kaori; Nettelbeck Dirk M; Dmitriev Igor; Krasnykh Victor; Mikheeva Galina V; Barnes Mack N; Alvarez Ronald D; Dall Peter; Alemany Ramon; Curiel David T; Hemminki Akseli
Treatment of ovarian cancer with a tropism modified oncolytic adenovirus.
Cancer research 2002;62(5):1266-70.
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2001: Alemany R; Curiel D T
CAR-binding ablation does not change biodistribution and toxicity of adenoviral vectors.
Gene therapy 2001;8(17):1347-53.
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2001: Hemminki A; Dmitriev I; Liu B; Desmond R A; Alemany R; Curiel D T
Targeting oncolytic adenoviral agents to the epidermal growth factor pathway with a secretory fusion molecule.
Cancer research 2001;61(17):6377-81.
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2001: Balagué C; Noya F; Alemany R; Chow L T; Curiel D T
Human papillomavirus E6E7-mediated adenovirus cell killing: selectivity of mutant adenovirus replication in organotypic cultures of human keratinocytes.
Journal of virology 2001;75(16):7602-11.
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2001: Alemany R; Gómez-Manzano C; Fueyo J
[Oncolytic adenovirus for the treatment of cerebral tumors: past, present and future]
Neurología (Barcelona, Spain) 2001;16(3):122-7.
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2001: Yamamoto M; Alemany R; Adachi Y; Grizzle W E; Curiel D T
Characterization of the cyclooxygenase-2 promoter in an adenoviral vector and its application for the mitigation of toxicity in suicide gene therapy of gastrointestinal cancers.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;3(3):385-94.
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2001: Suzuki K; Fueyo J; Krasnykh V; Reynolds P N; Curiel D T; Alemany R
A conditionally replicative adenovirus with enhanced infectivity shows improved oncolytic potency.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(1):120-6.
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2000: Alemany R; Suzuki K; Curiel D T
Blood clearance rates of adenovirus type 5 in mice.
The Journal of general virology 2000;81(Pt 11):2605-9.
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2000: Alemany R; Balagué C; Curiel D T
Replicative adenoviruses for cancer therapy.
Nature biotechnology 2000;18(7):723-7.
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2000: Fueyo J; Gomez-Manzano C; Alemany R; Lee P S; McDonnell T J; Mitlianga P; Shi Y X; Levin V A; Yung W K; Kyritsis A P
A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo.
Oncogene 2000;19(1):2-12.
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1999: Alemany R; Gomez-Manzano C; Balagué C; Yung W K; Curiel D T; Kyritsis A P; Fueyo J
Gene therapy for gliomas: molecular targets, adenoviral vectors, and oncolytic adenoviruses.
Experimental cell research 1999;252(1):1-12.
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1998: Fueyo J; Gomez-Manzano C; Yung W K; Liu T J; Alemany R; McDonnell T J; Shi X; Rao J S; Levin V A; Kyritsis A P
Overexpression of E2F-1 in glioma triggers apoptosis and suppresses tumor growth in vitro and in vivo.
Nature medicine 1998;4(6):685-90.
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1998: Fueyo J; Gomez-Manzano C; Yung W K; Liu T J; Alemany R; Bruner J M; Chintala S K; Rao J S; Levin V A; Kyritsis A P
Suppression of human glioma growth by adenovirus-mediated Rb gene transfer.
Neurology 1998;50(5):1307-15.
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1996: Hamada K; Sakaue M; Alemany R; Zhang W W; Horio Y; Roth J A; Mitchell M F
Adenovirus-mediated transfer of HPV 16 E6/E7 antisense RNA to human cervical cancer cells.
Gynecologic oncology 1996;63(2):219-27.
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1996: Alemany R; Ruan S; Kataoka M; Koch P E; Mukhopadhyay T; Cristiano R J; Roth J A; Zhang W W
Growth inhibitory effect of anti-K-ras adenovirus on lung cancer cells.
Cancer gene therapy 1996;3(5):296-301.
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1996: Hamada K; Alemany R; Zhang W W; Hittelman W N; Lotan R; Roth J A; Mitchell M F
Adenovirus-mediated transfer of a wild-type p53 gene and induction of apoptosis in cervical cancer.
Cancer research 1996;56(13):3047-54.
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1996: Hamada K; Zhang W W; Alemany R; Wolf J; Roth J A; Mitchell M F
Growth inhibition of human cervical cancer cells with the recombinant adenovirus p53 in vitro.
Gynecologic oncology 1996;60(3):373-9.
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1995: Zhang W W; Alemany R; Wang J; Koch P E; Ordonez N G; Roth J A
Safety evaluation of Ad5CMV-p53 in vitro and in vivo.
Human gene therapy 1995;6(2):155-64.
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