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Kazuhiro Chida

Research Profile

Living Beings

Mouse
Rats

Chemicals & Drugs

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Phosphorylation

Physiology

Anatomy

Disorders

Skin Neoplasms

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Publications

TOP 3
Yosuke Yoneyama; Kazumi Take; Kazuhiro Chida; Fumihiko Hakuno; Tomohiro Kabuta; Masao Matsuo; Shin-Ichiro Takahashi
The AP-1 Complex Regulates Intracellular Localization of Insulin Receptor Substrate 1, Which Is Required for Insulin-Like Growth Factor I-Dependent Cell Proliferation.
Yohei Yoshihama; Kei Satoh; Yoshinori Satoh; Ryo Takagawa; Kazunori Akimoto; Hirotoshi Akiyama; Kazuhiro Chida; Itaru Endo; Yasushi Ichikawa; Yoshiaki Inayama; Yusuke Izumisawa; Chikara Kunisaki; Taichi Mizushima; Yoji Nagashima; Shigeo Ohno
High expression of KIBRA in low atypical protein kinase C-expressing gastric cancer correlates with lymphatic invasion and poor prognosis.
Toshiaki Fukushima; Fumihiko Hakuno; Shiro Minami; Yusaku Nakamura; Takashi Shibano; Tomoichiro Asano; Kazuhiro Chida; Daisuke Yamanaka; Shin-Ichiro Takahashi
Phosphatidylinositol 3-kinase (PI3K) activity bound to insulin-like growth factor-I (IGF-I) receptor, which is continuously sustained by IGF-I stimulation, is required for IGF-I-induced cell proliferation.

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All Publications

2013: Yosuke Yoneyama; Kazumi Take; Kazuhiro Chida; Fumihiko Hakuno; Tomohiro Kabuta; Masao Matsuo; Shin-Ichiro Takahashi
The AP-1 Complex Regulates Intracellular Localization of Insulin Receptor Substrate 1, Which Is Required for Insulin-Like Growth Factor I-Dependent Cell Proliferation.
Molecular and cellular biology 2013;33(10):1991-2003.
2013: Yohei Yoshihama; Kei Satoh; Yoshinori Satoh; Ryo Takagawa; Kazunori Akimoto; Hirotoshi Akiyama; Kazuhiro Chida; Itaru Endo; Yasushi Ichikawa; Yoshiaki Inayama; Yusuke Izumisawa; Chikara Kunisaki; Taichi Mizushima; Yoji Nagashima; Shigeo Ohno
High expression of KIBRA in low atypical protein kinase C-expressing gastric cancer correlates with lymphatic invasion and poor prognosis.
Cancer science 2013;104(2):259-65.
2012: Toshiaki Fukushima; Fumihiko Hakuno; Shiro Minami; Yusaku Nakamura; Takashi Shibano; Tomoichiro Asano; Kazuhiro Chida; Daisuke Yamanaka; Shin-Ichiro Takahashi
Phosphatidylinositol 3-kinase (PI3K) activity bound to insulin-like growth factor-I (IGF-I) receptor, which is continuously sustained by IGF-I stimulation, is required for IGF-I-induced cell proliferation.
The Journal of biological chemistry 2012;287(35):29713-21.
2012: Takeshi Hara; Shoji Matsumura; Shin-Ichiro Takahashi; Fumihiko Hakuno; Kazuhiro Chida
PKCα suppresses 7,12-dimethylbenz[a]anthracene-induced skin tumor formation.
Anticancer research 2012;32(8):3097-101.
2012: Hidehito Yoshihara; Keiji Tanaka; Minoru Yoshida; Tomoichiro Asano; Kazuhiro Chida; Toshiaki Fukushima; Leonard Girnita; Fumihiko Hakuno; Shun-ichiro Iemura; Akihiro Ito; Tohru Natsume; Yasushi Saeki; Shin-Ichiro Takahashi
Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs.
Biochemical and biophysical research communications 2012;423(1):122-7.
2012: Daisuke Yamanaka; Takeshi Akama; Kazuhiro Chida; Toshiaki Fukushima; Fumihiko Hakuno; Chie Kawasaki; Shiro Minami; Taku Nedachi; Koichi Suzuki; Shin-Ichiro Takahashi
Phosphatidylinositol 3-kinase-binding protein, PI3KAP/XB130, is required for cAMP-induced amplification of IGF mitogenic activity in FRTL-5 thyroid cells.
Molecular endocrinology (Baltimore, Md.) 2012;26(6):1043-55.
2011: Toshiaki Fukushima; Fumihiko Hakuno; Akihiro Ito; Shinji Nagata; Hiroshi Okajima; Miyako Ariga; Tomoichiro Asano; Kazuhiro Chida; Daisuke Yamanaka; Minoru Yoshida; Shin-Ichiro Takahashi
HSP90 interacting with IRS-2 is involved in cAMP-dependent potentiation of IGF-I signals in FRTL-5 cells.
Molecular and cellular endocrinology 2011;344(1-2):81-9.
2011: Yohei Yoshihama; Kazunori Sasaki; Yosuke Horikoshi; Atsushi Suzuki; Takashi Ohtsuka; Fumihiko Hakuno; Shin-Ichiro Takahashi; Shigeo Ohno; Kazuhiro Chida
KIBRA suppresses apical exocytosis through inhibition of aPKC kinase activity in epithelial cells.
Current biology : CB 2011;21(8):705-11.
2011: Toshiaki Fukushima; Toshiya Arai; Miyako Ariga-Nedachi; Hiroshi Okajima; Yuko Ooi; Yumi Iijima; Meri Sone; Yoshitake Cho; Yasutoshi Ando; Kohei Kasahara; Atsufumi Ozoe; Hidehito Yoshihara; Kazuhiro Chida; Shigeru Okada; John J Kopchick; Tomoichiro Asano; Fumihiko Hakuno; Shin-Ichiro Takahashi
Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases.
Biochemical and biophysical research communications 2011;404(3):767-73.
2011: Fumihiko Hakuno; Tatsuhiko Kadowaki; Gen Kaneko; Jun Nakae; Masugi Nishihara; Keitaro Yamanouchi; Yoko Yamauchi; Yosuke Yoneyama; Kazuhiro Chida; Shin-Ichiro Takahashi
Constitutive expression of insulin receptor substrate (IRS)-1 inhibits myogenic differentiation through nuclear exclusion of Foxo1 in L6 myoblasts.
PloS one 2011;6(10):e25655.
2010: Michihiro Shibata; Fumihiko Hakuno; Daisuke Yamanaka; Hiroshi Okajima; Toshiaki Fukushima; Takashi Hasegawa; Tomomi Ogata; Yuka Toyoshima; Kazuhiro Chida; Kumi Kimura; Hideyuki Sakoda; A Takenaka; Tomoichiro Asano; Shin-Ichiro Takahashi
Paraquat-induced oxidative stress represses phosphatidylinositol 3-kinase activities leading to impaired glucose uptake in 3T3-L1 adipocytes.
The Journal of biological chemistry 2010;285(27):20915-25.
2010: Tomohiro Kabuta; Fumihiko Hakuno; Yoshitake Cho; Daisuke Yamanaka; Kazuhiro Chida; Tomoichiro Asano; Keiji Wada; Shin-Ichiro Takahashi
Insulin receptor substrate-3, interacting with Bcl-3, enhances p50 NF-kappaB activity.
Biochemical and biophysical research communications 2010;394(3):697-702.
2009: Takayuki Iriyama; Kohsuke Takeda; Hiromi Nakamura; Yoshifumi Morimoto; Takumi Kuroiwa; Junya Mizukami; Tsuyoshi Umeda; Takuya Noguchi; Isao Naguro; Hideki Nishitoh; Kaoru Saegusa; Kei Tobiume; Toshiki Homma; Yutaka Shimada; Hitoshi Tsuda; Satoshi Aiko; Issei Imoto; Johji Inazawa; Kazuhiro Chida; Yoshimasa Kamei; Shiro Kozuma; Yuji Taketani; Atsushi Matsuzawa; Hidenori Ichijo
ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis.
The EMBO journal 2009;28(7):843-53.
2009: Naoko Sasaki-Suzuki; K i Arai; Tomomi Ogata; Kouhei Kasahara; Hideyuki Sakoda; Kazuhiro Chida; Tomoichiro Asano; Jeffrey Pessin; Fumihiko Hakuno; Shin-Ichiro Takahashi
Growth hormone inhibition of glucose uptake in adipocytes occurs without affecting GLUT4 translocation through an insulin receptor substrate-2-phosphatidylinositol 3-kinase-dependent pathway.
The Journal of biological chemistry 2009;284(10):6061-70.
2009: Yohei Yoshihama; Takaaki Hirai; Takashi Ohtsuka; Kazuhiro Chida
KIBRA Co-localizes with protein kinase Mzeta (PKMzeta) in the mouse hippocampus.
Bioscience, biotechnology, and biochemistry 2009;73(1):147-51.
2006: Shuzo Ikuta; Nobufumi Sekino; Takeshi Hara; Yuriko Saito; Kazuhiro Chida
Mouse epidermal keratinocytes in three-dimensional organotypic coculture with dermal fibroblasts form a stratified sheet resembling skin.
Bioscience, biotechnology, and biochemistry 2006;70(11):2669-75.
2005: Takeshi Hara; Yuriko Saito; Takaaki Hirai; Kenji Nakamura; Kazuki Nakao; Motoya Katsuki; Kazuhiro Chida
Deficiency of protein kinase Calpha in mice results in impairment of epidermal hyperplasia and enhancement of tumor formation in two-stage skin carcinogenesis.
Cancer research 2005;65(16):7356-62.
2003: Takaaki Hirai; Yuko S Niino; Kazuhiro Chida
PKC zeta II, a small molecule of protein kinase C zeta, specifically expressed in the mouse brain.
Neuroscience letters 2003;348(3):151-4.
2003: Kazuhiro Chida; Takeshi Hara; Takaaki Hirai; Chieko Konishi; Kenji Nakamura; Kazuki Nakao; Atsu Aiba; Motoya Katsuki; Toshio Kuroki
Disruption of protein kinase Ceta results in impairment of wound healing and enhancement of tumor formation in mouse skin carcinogenesis.
Cancer research 2003;63(10):2404-8.
2003: Takaaki Hirai; Kazuhiro Chida
Protein kinase Czeta (PKCzeta): activation mechanisms and cellular functions.
Journal of biochemistry 2003;133(1):1-7.
2003: Kazuyuki Tobe; Shohji Asai; Koozi Matuoka; Tadashi Yamamoto; Kazuhiro Chida; Yasushi Kaburagi; Yasuo Akanuma; Toshio Kuroki; Tadaomi Takenawa; Satoshi Kimura; Ryozo Nagai; Takashi Kadowaki
Cytoskeletal reorganization induced by insulin: involvement of Grb2/Ash, Ras and phosphatidylinositol 3-kinase signalling.
Genes to cells : devoted to molecular & cellular mechanisms 2003;8(1):29-40.
2002: Takeshi Hara; Kazuhiro Chida
Genomic organization and chromosomal localization of the mouse protein kinase C alpha gene.
Gene 2002;291(1-2):11-6.