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Shu Chien
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27
Shyy, John Y-J
26
Usami, Shunichi
23
Skalak, R
20
Li, Song
19
Li, Yi-Shuan
18
Sung, Paul
14
Chiu, Jeng-Jiann
10
Wang, Yingxiao
9
Lee, Pei-Ling
8
Yuan, Suli
7
Chen, Benjamin
6
Chen, Kuang-Den
6
Chen, Li-Jing
6
Kaunas, Roland
6
Hu, Ying-Li
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All Publications
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2009: Brafman David A; Shah Kevan D; Fellner Thomas; Chien Shu; Willert Karl
Defining long-term maintenance conditions of human embryonic stem cells with arrayed cellular microenvironment technology.
Stem cells and development 2009;18(8):1141-54.
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2009: Tsai Min-Chien; Chen Lihong; Zhou Jing; Tang Zhihui; Hsu Tzu-Fang; Wang Ying; Shih Yu-Tsung; Peng Hsin-Hsin; Wang Nanping; Guan Youfei; Chien Shu; Chiu Jeng-Jiann
Shear stress induces synthetic-to-contractile phenotypic modulation in smooth muscle cells via peroxisome proliferator-activated receptor alpha/delta activations by prostacyclin released by sheared endothelial cells.
Circulation research 2009;105(5):471-80.
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2009: Oh Seunghan; Brammer Karla S; Li Y S Julie; Teng Dayu; Engler Adam J; Chien Shu; Jin Sungho
Stem cell fate dictated solely by altered nanotube dimension.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(7):2130-5.
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2009: Chiu Jeng-Jiann; Usami Shunichi; Chien Shu
Vascular endothelial responses to altered shear stress: pathologic implications for atherosclerosis.
Annals of medicine 2009;41(1):19-28.
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2008: del Alamo Juan C; Norwich Gerard N; Li Yi-shuan Julie; Lasheras Juan C; Chien Shu
Anisotropic rheology and directional mechanotransduction in vascular endothelial cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(40):15411-6.
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2008: Goldfinger Lawrence E; Tzima Eleni; Stockton Rebecca; Kiosses William B; Kinbara Kayoko; Tkachenko Eugene; Gutierrez Edgar; Groisman Alex; Nguyen Phu; Chien Shu; Ginsberg Mark H
Localized alpha4 integrin phosphorylation directs shear stress-induced endothelial cell alignment.
Circulation research 2008;103(2):177-85.
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2008: Haga Jason H; Kaunas Roland; Radeff-Huang Julie; Weems Jessica M; Estrada Kristine D; Chien Shu; Brown Joan Heller; Seasholtz Tammy M
Pulsatile equibiaxial stretch inhibits thrombin-induced RhoA and NF-kappaB activation.
Biochemical and biophysical research communications 2008;372(1):216-20.
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2008: Lee Ding-Yu; Yeh Chiuan-Ren; Chang Shun-Fu; Lee Pei-Ling; Chien Shu; Cheng Cheng-Kung; Chiu Jeng-Jiann
Integrin-mediated expression of bone formation-related genes in osteoblast-like cells in response to fluid shear stress: roles of extracellular matrix, Shc, and mitogen-activated protein kinase.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2008;23(7):1140-9.
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2008: Chien Shu
Effects of disturbed flow on endothelial cells.
Annals of biomedical engineering 2008;36(4):554-62.
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2007: Hornberger Troy Alan; Sukhija Kunal Balu; Wang Xiao-Rong; Chien Shu
mTOR is the rapamycin-sensitive kinase that confers mechanically-induced phosphorylation of the hydrophobic motif site Thr(389) in p70(S6k).
FEBS letters 2007;581(24):4562-6.
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2007: Chiu Jeng-Jiann; Chen Li-Jing; Lee Chih-I; Lee Pei-Ling; Lee Ding-Yu; Tsai Min-Chien; Lin Chia-Wen; Usami Shunichi; Chien Shu
Mechanisms of induction of endothelial cell E-selectin expression by smooth muscle cells and its inhibition by shear stress.
Blood 2007;110(2):519-28.
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2007: Hu Ying-Li; Chien Shu
Dynamic motion of paxillin on actin filaments in living endothelial cells.
Biochemical and biophysical research communications 2007;357(4):871-6.
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2007: Wang Yingxiao; Chang Joann; Chen Kuang-Den; Li Song; Li Julie Yi-Shuan; Wu Chuanyue; Chien Shu
Selective adapter recruitment and differential signaling networks by VEGF vs. shear stress.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(21):8875-9.
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2007: Guo Deliang; Chien Shu; Shyy John Y-J
Regulation of endothelial cell cycle by laminar versus oscillatory flow: distinct modes of interactions of AMP-activated protein kinase and Akt pathways.
Circulation research 2007;100(4):564-71.
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2007: Wu Chia-Ching; Li Yi-Shuan; Haga Jason H; Kaunas Roland; Chiu Jeng-Jiann; Su Fong-Chin; Usami Shunichi; Chien Shu
Directional shear flow and Rho activation prevent the endothelial cell apoptosis induced by micropatterned anisotropic geometry.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(4):1254-9.
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2007: D'Lima Darryl D; Patil Shantanu; Steklov Nikolai; Chien Shu; Colwell Clifford W
In vivo knee moments and shear after total knee arthroplasty.
Journal of biomechanics 2007;40 Suppl 1():S11-7.
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2007: Haga Jason H; Li Yi-Shuan J; Chien Shu
Molecular basis of the effects of mechanical stretch on vascular smooth muscle cells.
Journal of biomechanics 2007;40(5):947-60.
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2006: Kaunas Roland; Usami Shunichi; Chien Shu
Regulation of stretch-induced JNK activation by stress fiber orientation.
Cellular signalling 2006;18(11):1924-31.
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2006: Hu Ying-Li; Haga Jason H; Miao Hui; Wang Yingxiao; Li Yi-Shuan; Chien Shu
Roles of microfilaments and microtubules in paxillin dynamics.
Biochemical and biophysical research communications 2006;348(4):1463-71.
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2006: Lien Sheng-Chieh; Usami Shunichi; Chien Shu; Chiu Jeng-Jiann
Phosphatidylinositol 3-kinase/Akt pathway is involved in transforming growth factor-beta1-induced phenotypic modulation of 10T1/2 cells to smooth muscle cells.
Cellular signalling 2006;18(8):1270-8.
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2006: Hornberger Troy Alan; Sukhija Kunal Balu; Chien Shu
Regulation of mTOR by mechanically induced signaling events in skeletal muscle.
Cell cycle (Georgetown, Tex.) 2006;5(13):1391-6.
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2006: Hornberger Troy A; Chien Shu
Mechanical stimuli and nutrients regulate rapamycin-sensitive signaling through distinct mechanisms in skeletal muscle.
Journal of cellular biochemistry 2006;97(6):1207-16.
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2006: Hornberger T A; Chu W K; Mak Y W; Hsiung J W; Huang S A; Chien S
The role of phospholipase D and phosphatidic acid in the mechanical activation of mTOR signaling in skeletal muscle.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(12):4741-6.
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2006: Wang Nanping; Miao Hui; Li Yi-Shuan; Zhang Peng; Haga Jason H; Hu Yingli; Young Angela; Yuan Suli; Nguyen Phu; Wu Chia-Ching; Chien Shu
Shear stress regulation of Krüppel-like factor 2 expression is flow pattern-specific.
Biochemical and biophysical research communications 2006;341(4):1244-51.
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2006: Chen Cheng-Nan; Chang Shun-Fu; Lee Pei-Ling; Chang Kyle; Chen Li-Jing; Usami Shunichi; Chien Shu; Chiu Jeng-Jiann
Neutrophils, lymphocytes, and monocytes exhibit diverse behaviors in transendothelial and subendothelial migrations under coculture with smooth muscle cells in disturbed flow.
Blood 2006;107(5):1933-42.
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2006: Chen Cheng-Nan; Li Yi-Shuan J; Yeh Yi-Ting; Lee Pei-Ling; Usami Shunichi; Chien Shu; Chiu Jeng-Jiann
Synergistic roles of platelet-derived growth factor-BB and interleukin-1beta in phenotypic modulation of human aortic smooth muscle cells.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(8):2665-70.
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2006: Wang Yingxiao; Jin Gang; Miao Hui; Li Julie Y-S; Usami Shunichi; Chien Shu
Integrins regulate VE-cadherin and catenins: dependence of this regulation on Src, but not on Ras.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(6):1774-9.
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2006: Lorenzen-Schmidt Ilka; Schmid-Schönbein Geert W; Giles Wayne R; McCulloch Andrew D; Chien Shu; Omens Jeffrey H
Chronotropic response of cultured neonatal rat ventricular myocytes to short-term fluid shear.
Cell biochemistry and biophysics 2006;46(2):113-22.
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2006: Chien Shu
Molecular basis of rheological modulation of endothelial functions: importance of stress direction.
Biorheology 2006;43(2):95-116.
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2005: Kaunas Roland; Nguyen Phu; Usami Shunichi; Chien Shu
Cooperative effects of Rho and mechanical stretch on stress fiber organization.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(44):15895-900.
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2005: Li Yi-Shuan J; Haga Jason H; Chien Shu
Molecular basis of the effects of shear stress on vascular endothelial cells.
Journal of biomechanics 2005;38(10):1949-71.
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2005: Chiu Jeng-Jiann; Chen Li-Jing; Chang Shun-Fu; Lee Pei-Ling; Lee Chih-I; Tsai Min-Chien; Lee Ding-Yu; Hsieh Hsing-Pang; Usami Shunichi; Chien Shu
Shear stress inhibits smooth muscle cell-induced inflammatory gene expression in endothelial cells: role of NF-kappaB.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(5):963-9.
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2005: Wang Yingxiao; Botvinick Elliot L; Zhao Yihua; Berns Michael W; Usami Shunichi; Tsien Roger Y; Chien Shu
Visualizing the mechanical activation of Src.
Nature 2005;434(7036):1040-5.
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2005: Makino Ayako; Glogauer Michael; Bokoch Gary M; Chien Shu; Schmid-Schönbein Geert W
Control of neutrophil pseudopods by fluid shear: role of Rho family GTPases.
American journal of physiology. Cell physiology 2005;288(4):C863-71.
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2005: Miao Hui; Hu Ying-Li; Shiu Yan-Ting; Yuan Suli; Zhao Yihua; Kaunas Roland; Wang Yingxiao; Jin Gang; Usami Shunichi; Chien Shu
Effects of flow patterns on the localization and expression of VE-cadherin at vascular endothelial cell junctions: in vivo and in vitro investigations.
Journal of vascular research 2005;42(1):77-89.
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2005: Li Song; Guan Jun-Lin; Chien Shu
Biochemistry and biomechanics of cell motility.
Annual review of biomedical engineering 2005;7():105-50.
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2005: Chiu Jeng-Jiann; Lee Pei-Ling; Chang Shun-Fu; Chen Li-Jing; Lee Chih-I; Lin Kurt M; Usami Shunichi; Chien Shu
Shear stress regulates gene expression in vascular endothelial cells in response to tumor necrosis factor-alpha: a study of the transcription profile with complementary DNA microarray.
Journal of biomedical science 2005;12(3):481-502.
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2005: Chien Shu; Li Song; Shiu Yan-Ting; Li Yi-Shuan
Molecular basis of mechanical modulation of endothelial cell migration.
Frontiers in bioscience : a journal and virtual library 2005;10():1985-2000.
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2004: Liu Yi; Zhu Yi; Rannou Francois; Lee Tzong-Shyuan; Formentin Kitty; Zeng Lingfang; Yuan Xiaohui; Wang Nanping; Chien Shu; Forman Barry M; Shyy John Y-J
Laminar flow activates peroxisome proliferator-activated receptor-gamma in vascular endothelial cells.
Circulation 2004;110(9):1128-33.
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2004: Shiu Yan-Ting; Li Song; Marganski William A; Usami Shunichi; Schwartz Martin A; Wang Yu-Li; Dembo Micah; Chien Shu
Rho mediates the shear-enhancement of endothelial cell migration and traction force generation.
Biophysical journal 2004;86(4):2558-65.
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2004: Wang Yingxiao; Chang Joann; Li Yi-Chen; Li Yi-Shuan; Shyy John Y-J; Chien Shu
Shear stress and VEGF activate IKK via the Flk-1/Cbl/Akt signaling pathway.
American journal of physiology. Heart and circulatory physiology 2004;286(2):H685-92.
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2004: Chiu Jeng-Jiann; Lee Pei-Ling; Chen Cheng-Nan; Lee Chih-I; Chang Shun-Fu; Chen Li-Jing; Lien Sheng-Chieh; Ko Ya-Chen; Usami Shunichi; Chien Shu
Shear stress increases ICAM-1 and decreases VCAM-1 and E-selectin expressions induced by tumor necrosis factor-[alpha] in endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(1):73-9.
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2004: Chien Shu
The National Institute of Biomedical Imaging and Bioengineering.
Annual review of biomedical engineering 2004;6():1-26.
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2003: Chiu Jeng-Jiann; Chen Cheng-Nan; Lee Pei-Ling; Yang Cheng Tsair; Chuang Han Sheng; Chien Shu; Usami Shunichi
Analysis of the effect of disturbed flow on monocytic adhesion to endothelial cells.
Journal of biomechanics 2003;36(12):1883-95.
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2003: Zhou Rui-Hai; Lee Tzong-Shyuan; Tsou Tsui-Chun; Rannou François; Li Yi-Shuan; Chien Shu; Shyy John Y-J
Stent implantation activates Akt in the vessel wall: role of mechanical stretch in vascular smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(11):2015-20.
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2003: Chien Shu
Molecular and mechanical bases of focal lipid accumulation in arterial wall.
Progress in biophysics and molecular biology 2003;83(2):131-51.
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2003: Li Song; Moon James Jaehyun; Miao Hui; Jin Gang; Chen Benjamin P C; Yuan Suli; Hu Yingli; Usami Shunichi; Chien Shu
Signal transduction in matrix contraction and the migration of vascular smooth muscle cells in three-dimensional matrix.
Journal of vascular research 2003;40(4):378-88.
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2003: Zeng Lingfang; Zhang Yingjia; Chien Shu; Liu Xuan; Shyy John Y-J
The role of p53 deacetylation in p21Waf1 regulation by laminar flow.
The Journal of biological chemistry 2003;278(27):24594-9.
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2003: Lin Tong; Zeng Lingfang; Liu Yi; DeFea Kathryn; Schwartz Martin A; Chien Shu; Shyy John Y-J
Rho-ROCK-LIMK-cofilin pathway regulates shear stress activation of sterol regulatory element binding proteins.
Circulation research 2003;92(12):1296-304.
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2003: Shiu Yan-Ting; Li Song; Yuan Suli; Wang YingXiao; Nguyen Phu; Chien Shu
Shear stress-induced c-fos activation is mediated by Rho in a calcium-dependent manner.
Biochemical and biophysical research communications 2003;303(2):548-55.
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2003: Chiu Jeng-Jiann; Chen Li-Jing; Lee Pei-Ling; Lee Chih-I; Lo Leu-Wei; Usami Shunichi; Chien Shu
Shear stress inhibits adhesion molecule expression in vascular endothelial cells induced by coculture with smooth muscle cells.
Blood 2003;101(7):2667-74.
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2003: Li Song; Lao Jianmin; Chen Benjamin P C; Li Yi-shuan; Zhao Yihua; Chu Julia; Chen Kuang-Den; Tsou Tsui-Chun; Peck Konan; Chien Shu
Genomic analysis of smooth muscle cells in 3-dimensional collagen matrix.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(1):97-9.
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2003: Labrador Vénus; Chen Kuang-Den; Li Yi-Shuan; Muller Sylvaine; Stoltz Jean-François; Chien Shu
Interactions of mechanotransduction pathways.
Biorheology 2003;40(1-3):47-52.
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2002: Tzima Eleni; Del Pozo Miguel Angel; Kiosses William B; Mohamed Samih A; Li Song; Chien Shu; Schwartz Martin Alexander
Activation of Rac1 by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression.
The EMBO journal 2002;21(24):6791-800.
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2002: Zhao Yihua; Chen Benjamin P C; Miao Hui; Yuan Suli; Li Yi-Shuan; Hu Yingli; Rocke David M; Chien Shu
Improved significance test for DNA microarray data: temporal effects of shear stress on endothelial genes.
Physiological genomics 2002;12(1):1-11.
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2002: Hu Ying-Li; Li Song; Miao Hui; Tsou Tsui-Chun; del Pozo Miguel Angel; Chien Shu
Roles of microtubule dynamics and small GTPase Rac in endothelial cell migration and lamellipodium formation under flow.
Journal of vascular research 2002;39(6):465-76.
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2002: Shyy John Y-J; Chien Shu
Role of integrins in endothelial mechanosensing of shear stress.
Circulation research 2002;91(9):769-75.
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2002: Wang Yingxiao; Miao Hui; Li Song; Chen Kuang-Den; Li Yi-Shuan; Yuan Suli; Shyy John Y-J; Chien Shu
Interplay between integrins and FLK-1 in shear stress-induced signaling.
American journal of physiology. Cell physiology 2002;283(5):C1540-7.
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2002: Yajima Noriyuki; Masuda Masahisa; Miyazaki Masaru; Nakajima Nobuyuki; Chien Shu; Shyy John Y-J
Oxidative stress is involved in the development of experimental abdominal aortic aneurysm: a study of the transcription profile with complementary DNA microarray.
Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter 2002;36(2):379-85.
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2002: Katsumi Akira; Milanini Julie; Kiosses William B; del Pozo Miguel A; Kaunas Roland; Chien Shu; Hahn Klaus M; Schwartz Martin Alexander
Effects of cell tension on the small GTPase Rac.
The Journal of cell biology 2002;158(1):153-64.
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2002: Miao Hui; Li Song; Hu Ying-Li; Yuan Suli; Zhao Yihua; Chen Benjamin P C; Puzon-McLaughlin Wilma; Tarui Takehiko; Shyy John Y-J; Takada Yoshikazu; Usami Shunichi; Chien Shu
Differential regulation of Rho GTPases by beta1 and beta3 integrins: the role of an extracellular domain of integrin in intracellular signaling.
Journal of cell science 2002;115(Pt 10):2199-206.
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2002: Sotoudeh Mohammad; Li Yi-Shuan; Yajima Noriyuki; Chang Chih-Chieh; Tsou Tsui-Chun; Wang Yibin; Usami Shunichi; Ratcliffe Anthony; Chien Shu; Shyy John Y-J
Induction of apoptosis in vascular smooth muscle cells by mechanical stretch.
American journal of physiology. Heart and circulatory physiology 2002;282(5):H1709-16.
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2002: Miao Hui; Yuan Suli; Wang Yingxiao; Tsygankov Alexander; Chien Shu
Role of Cbl in shear-activation of PI 3-kinase and JNK in endothelial cells.
Biochemical and biophysical research communications 2002;292(4):892-9.
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2002: Li Song; Butler Peter; Wang Yingxiao; Hu Yingli; Han Dong Cho; Usami Shunichi; Guan Jun-Lin; Chien Shu
The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(6):3546-51.
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2002: Butler Peter J; Tsou Tsui-Chun; Li Julie Yi-Shuan; Usami Shunichi; Chien Shu
Rate sensitivity of shear-induced changes in the lateral diffusion of endothelial cell membrane lipids: a role for membrane perturbation in shear-induced MAPK activation.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(2):216-8.
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2002: Liu Yi; Chen Benjamin P-C; Lu Min; Zhu Yi; Stemerman Michael B; Chien Shu; Shyy John Y-J
Shear stress activation of SREBP1 in endothelial cells is mediated by integrins.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(1):76-81.
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2001: Chen B P; Li Y S; Zhao Y; Chen K D; Li S; Lao J; Yuan S; Shyy J Y; Chien S
DNA microarray analysis of gene expression in endothelial cells in response to 24-h shear stress.
Physiological genomics 2001;7(1):55-63.
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2001: Tzima E; del Pozo M A; Shattil S J; Chien S; Schwartz M A
Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignment.
The EMBO journal 2001;20(17):4639-47.
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2001: Hsu P P; Li S; Li Y S; Usami S; Ratcliffe A; Wang X; Chien S
Effects of flow patterns on endothelial cell migration into a zone of mechanical denudation.
Biochemical and biophysical research communications 2001;285(3):751-9.
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2001: Zhu Y; Liao H; Wang N; Ma K S; Verna L K; Shyy J Y; Chien S; Stemerman M B
LDL-activated p38 in endothelial cells is mediated by Ras.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(7):1159-64.
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2001: Zhao Y; Chien S; Skalak R; Lipowsky H H
Leukocyte rolling in rat mesentery venules: distribution of adhesion bonds and the effects of cytoactive agents.
Annals of biomedical engineering 2001;29(5):360-72.
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2001: Butler P J; Norwich G; Weinbaum S; Chien S
Shear stress induces a time- and position-dependent increase in endothelial cell membrane fluidity.
American journal of physiology. Cell physiology 2001;280(4):C962-9.
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2001: Zhao Y; Chien S; Weinbaum S
Dynamic contact forces on leukocyte microvilli and their penetration of the endothelial glycocalyx.
Biophysical journal 2001;80(3):1124-40.
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2001: Jalali S; del Pozo M A; Chen K; Miao H; Li Y; Schwartz M A; Shyy J Y; Chien S
Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(3):1042-6.
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2001: Li S; Bhatia S; Hu Y L; Shiu Y T; Li Y S; Usami S; Chien S
Effects of morphological patterning on endothelial cell migration.
Biorheology 2001;38(2-3):101-8.
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2000: Jin G; Sah R L; Li Y S; Lotz M; Shyy J Y; Chien S
Biomechanical regulation of matrix metalloproteinase-9 in cultured chondrocytes.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2000;18(6):899-908.
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2000: Lin K; Hsu P P; Chen B P; Yuan S; Usami S; Shyy J Y; Li Y S; Chien S
Molecular mechanism of endothelial growth arrest by laminar shear stress.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(17):9385-9.
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1999: Li S; Chien S; Brånemark P I
Heat shock-induced necrosis and apoptosis in osteoblasts.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1999;17(6):891-9.
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1999: Karlon W J; Hsu P P; Li S; Chien S; McCulloch A D; Omens J H
Measurement of orientation and distribution of cellular alignment and cytoskeletal organization.
Annals of biomedical engineering 1999;27(6):712-20.
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1999: Gregersen H; Lee T C; Chien S; Skalak R; Fung Y C
Strain distribution in the layered wall of the esophagus.
Journal of biomechanical engineering 1999;121(5):442-8.
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1999: Hu Y L; Li S; Shyy J Y; Chien S
Sustained JNK activation induces endothelial apoptosis: studies with colchicine and shear stress.
The American journal of physiology 1999;277(4 Pt 2):H1593-9.
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1999: Chen K D; Li Y S; Kim M; Li S; Yuan S; Chien S; Shyy J Y
Mechanotransduction in response to shear stress. Roles of receptor tyrosine kinases, integrins, and Shc.
The Journal of biological chemistry 1999;274(26):18393-400.
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1999: Li S; Chen B P; Azuma N; Hu Y L; Wu S Z; Sumpio B E; Shyy J Y; Chien S
Distinct roles for the small GTPases Cdc42 and Rho in endothelial responses to shear stress.
The Journal of clinical investigation 1999;103(8):1141-50.
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1999: Schinagl R M; Kurtis M S; Ellis K D; Chien S; Sah R L
Effect of seeding duration on the strength of chondrocyte adhesion to articular cartilage.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1999;17(1):121-9.
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1998: Chien S; Shyy J Y
Effects of hemodynamic forces on gene expression and signal transduction in endothelial cells.
The Biological bulletin 1998;194(3):390-1; discussion 392-3.
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1998: Sotoudeh M; Jalali S; Usami S; Shyy J Y; Chien S
A strain device imposing dynamic and uniform equi-biaxial strain to cultured cells.
Annals of biomedical engineering 1998;26(2):181-9.
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1998: Chiu J J; Wang D L; Chien S; Skalak R; Usami S
Effects of disturbed flow on endothelial cells.
Journal of biomechanical engineering 1998;120(1):2-8.
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1998: Jalali S; Li Y S; Sotoudeh M; Yuan S; Li S; Chien S; Shyy J Y
Shear stress activates p60src-Ras-MAPK signaling pathways in vascular endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(2):227-34.
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1998: Chien S; Li S; Shyy Y J
Effects of mechanical forces on signal transduction and gene expression in endothelial cells.
Hypertension 1998;31(1 Pt 2):162-9.
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1998: Galbraith C G; Skalak R; Chien S
Shear stress induces spatial reorganization of the endothelial cell cytoskeleton.
Cell motility and the cytoskeleton 1998;40(4):317-30.
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1997: Li S; Kim M; Hu Y L; Jalali S; Schlaepfer D D; Hunter T; Chien S; Shyy J Y
Fluid shear stress activation of focal adhesion kinase. Linking to mitogen-activated protein kinases.
The Journal of biological chemistry 1997;272(48):30455-62.
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1997: Gregersen H; Kassab G; Pallencaoe E; Lee C; Chien S; Skalak R; Fung Y C
Morphometry and strain distribution in guinea pig duodenum with reference to the zero-stress state.
The American journal of physiology 1997;273(4 Pt 1):G865-74.
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1997: Hansen J; Skalak R; Chien S; Hoger A
Spectrin properties and the elasticity of the red blood cell membrane skeleton.
Biorheology 1997;34(4-5):327-48.
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1997: Hansen J C; Skalak R; Chien S; Hoger A
Influence of network topology on the elasticity of the red blood cell membrane skeleton.
Biophysical journal 1997;72(5):2369-81.
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1997: Lin M C; Almus-Jacobs F; Chen H H; Parry G C; Mackman N; Shyy J Y; Chien S
Shear stress induction of the tissue factor gene.
The Journal of clinical investigation 1997;99(4):737-44.
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1997: Hu Y L; Chien S
Effects of shear stress on protein kinase C distribution in endothelial cells.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1997;45(2):237-49.
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1996: Li Y S; Shyy J Y; Li S; Lee J; Su B; Karin M; Chien S
The Ras-JNK pathway is involved in shear-induced gene expression.
Molecular and cellular biology 1996;16(11):5947-54.
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1996: Li S; Piotrowicz R S; Levin E G; Shyy Y J; Chien S
Fluid shear stress induces the phosphorylation of small heat shock proteins in vascular endothelial cells.
The American journal of physiology 1996;271(3 Pt 1):C994-1000.
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1996: Hansen J C; Skalak R; Chien S; Hoger A
An elastic network model based on the structure of the red blood cell membrane skeleton.
Biophysical journal 1996;70(1):146-66.
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1995: Shyy J Y; Li Y S; Lin M C; Chen W; Yuan S; Usami S; Chien S
Multiple cis-elements mediate shear stress-induced gene expression.
Journal of biomechanics 1995;28(12):1451-7.
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1995: Chen Y L; Jan K M; Lin H S; Chien S
Ultrastructural studies on macromolecular permeability in relation to endothelial cell turnover.
Atherosclerosis 1995;118(1):89-104.
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1995: Zhao Y; Chien S; Skalak R
A stochastic model of leukocyte rolling.
Biophysical journal 1995;69(4):1309-20.
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1995: Shyy J Y; Lin M C; Han J; Lu Y; Petrime M; Chien S
The cis-acting phorbol ester "12-O-tetradecanoylphorbol 13-acetate"-responsive element is involved in shear stress-induced monocyte chemotactic protein 1 gene expression.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(17):8069-73.
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1995: Wang D L; Wung B S; Shyy Y J; Lin C F; Chao Y J; Usami S; Chien S
Mechanical strain induces monocyte chemotactic protein-1 gene expression in endothelial cells. Effects of mechanical strain on monocyte adhesion to endothelial cells.
Circulation research 1995;77(2):294-302.
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1995: Skierczynski B A; Skalak R; Chien S
Modeling of molecular mechanisms of cell adhesion.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1995;73(7-8):399-409.
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1995: Schmid-Schönbein G W; Kosawada T; Skalak R; Chien S
Membrane model of endothelial cells and leukocytes. A proposal for the origin of a cortical stress.
Journal of biomechanical engineering 1995;117(2):171-8.
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1995: Itoh T; Chien S; Usami S
Effects of hemoglobin concentration on deformability of individual sickle cells after deoxygenation.
Blood 1995;85(8):2245-53.
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1994: Shyy Y J; Hsieh H J; Usami S; Chien S
Fluid shear stress induces a biphasic response of human monocyte chemotactic protein 1 gene expression in vascular endothelium.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(11):4678-82.
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1993: Skierczynski B A; Usami S; Chien S; Skalak R
Active motion of polymorphonuclear leukocytes in response to chemoattractant in a micropipette.
Journal of biomechanical engineering 1993;115(4B):503-9.
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1993: Shyy Y J; Wickham L L; Hagan J P; Hsieh H J; Hu Y L; Telian S H; Valente A J; Sung K L; Chien S
Human monocyte colony-stimulating factor stimulates the gene expression of monocyte chemotactic protein-1 and increases the adhesion of monocytes to endothelial monolayers.
The Journal of clinical investigation 1993;92(4):1745-51.
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1993: Sung K L; Frojmovic M M; O'Toole T E; Zhu C; Ginsberg M H; Chien S
Determination of adhesion force between single cell pairs generated by activated GpIIb-IIIa receptors.
Blood 1993;81(2):419-23.
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1993: Usami S; Chen H H; Zhao Y; Chien S; Skalak R
Design and construction of a linear shear stress flow chamber.
Annals of biomedical engineering 1993;21(1):77-83.
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1993: Skalak R; Skierczynski B A; Wung S L; Chien S; Usami S
Mechanical models of pseudopod formation.
Blood cells 1993;19(2):389-97; discussion 398-9.
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1992: Usami S; Wung S L; Skierczynski B A; Skalak R; Chien S
Locomotion forces generated by a polymorphonuclear leukocyte.
Biophysical journal 1992;63(6):1663-6.
-
1992: Chien S
The Benjamin W. Zweifach Award Lecture. Blood cell deformability and interactions: from molecules to micromechanics and microcirculation.
Microvascular research 1992;44(3):243-54.
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1992: Sung K L; Kuhlman P; Maldonado F; Lollo B A; Chien S; Brian A A
Force contribution of the LFA-1/ICAM-1 complex to T cell adhesion.
Journal of cell science 1992;103 ( Pt 1)():259-66.
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1992: Chang R R; Chien N T; Chen C H; Jan K M; Schmid-Schönbein G W; Chien S
Spontaneous activation of circulating granulocytes in patients with acute myocardial and cerebral diseases.
Biorheology 1992;29(5-6):549-61.
-
1992: Chien S; Sung L A; Lee M M; Skalak R
Red cell membrane elasticity as determined by flow channel technique.
Biorheology 1992;29(5-6):467-78.
-
1992: Huang A L; Jan K M; Chien S
Role of intercellular junctions in the passage of horseradish peroxidase across aortic endothelium.
Laboratory investigation; a journal of technical methods and pathology 1992;67(2):201-9.
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1992: Sung L A; Chien S; Fan Y S; Lin C C; Lambert K; Zhu L; Lam J S; Chang L S
Human erythrocyte protein 4.2: isoform expression, differential splicing, and chromosomal assignment.
Blood 1992;79(10):2763-70.
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1992: Itoh T; Chien S; Usami S
Deformability measurements on individual sickle cells using a new system with pO2 and temperature control.
Blood 1992;79(8):2141-7.
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1992: Tözeren A; Sung K L; Sung L A; Dustin M L; Chan P Y; Springer T A; Chien S
Micromanipulation of adhesion of a Jurkat cell to a planar bilayer membrane containing lymphocyte function-associated antigen 3 molecules.
The Journal of cell biology 1992;116(4):997-1006.
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1992: Sung L A; Fowler V M; Lambert K; Sussman M A; Karr D; Chien S
Molecular cloning and characterization of human fetal liver tropomodulin. A tropomyosin-binding protein.
The Journal of biological chemistry 1992;267(4):2616-21.
-
1992: Sung K L; Chien S
Influence of temperature on rheology of human erythrocytes.
The Chinese journal of physiology 1992;35(2):81-94.
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1991: Reinhart W H; Huang C; Vayo M; Norwich G; Chien S; Skalak R
Folding of red blood cells in capillaries and narrow pores.
Biorheology 1991;28(6):537-49.
-
1990: Lin S J; Jan K M; Chien S
Temporal and spatial changes in macromolecular uptake in rat thoracic aorta and relation to [3H]thymidine uptake.
Atherosclerosis 1990;85(2-3):229-38.
-
1990: Simchon S; Carlin R D; Jan K M; Chien S
A double isotope technique to determine regional albumin permeability: effects of anesthesia.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1990;195(1):114-8.
-
1990: Lin S J; Jan K M; Chien S
Role of dying endothelial cells in transendothelial macromolecular transport.
Arteriosclerosis (Dallas, Tex.) 1990;10(5):703-9.
-
1990: Chuang P T; Cheng H J; Lin S J; Jan K M; Lee M M; Chien S
Macromolecular transport across arterial and venous endothelium in rats. Studies with Evans blue-albumin and horseradish peroxidase.
Arteriosclerosis (Dallas, Tex.) 1990;10(2):188-97.
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1990: Sung L A; Chien S; Chang L S; Lambert K; Bliss S A; Bouhassira E E; Nagel R L; Schwartz R S; Rybicki A C
Molecular cloning of human protein 4.2: a major component of the erythrocyte membrane.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(3):955-9.
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1990: Chien S; Feng S S; Vayo M; Sung L A; Usami S; Skalak R
The dynamics of shear disaggregation of red blood cells in a flow channel.
Biorheology 1990;27(2):135-47.
-
1990: Chien S; Sung L P
Molecular basis of red cell membrane rheology. Part 1.
Biorheology 1990;27(3-4):327-44.
-
1990: Jan K M; Powers E; Reinhart W; Berke A; Nichols A; Watson R; Reison D; Schwartz A; Chien S
Altered rheological properties of blood following administrations of tissue plasminogen activator and streptokinase in patients with acute myocardial infarction.
Advances in experimental medicine and biology 1990;281():409-17.
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1989: Schmalzer E A; Manning R S; Chien S
Filtration of sickle cells: recruitment into a rigid fraction as a function of density and oxygen tension.
The Journal of laboratory and clinical medicine 1989;113(6):727-34.
-
1989: Simchon S; Manger W M; Carlin R D; Peeters L L; Rodriguez J; Batista D; Brown T; Merchant N B; Jan K M; Chien S
Salt-induced hypertension in Dahl salt-sensitive rats. Hemodynamics and renal responses.
Hypertension 1989;13(6 Pt 1):612-21.
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1989: Lin S J; Jan K M; Weinbaum S; Chien S
Transendothelial transport of low density lipoprotein in association with cell mitosis in rat aorta.
Arteriosclerosis (Dallas, Tex.) 1989;9(2):230-6.
-
1989: Tozeren A; Sung K L; Chien S
Theoretical and experimental studies on cross-bridge migration during cell disaggregation.
Biophysical journal 1989;55(3):479-87.
-
1989: Chen R Y; Carlin R D; Simchon S; Jan K M; Chien S
Effects of dextran-induced hyperviscosity on regional blood flow and hemodynamics in dogs.
The American journal of physiology 1989;256(3 Pt 2):H898-905.
-
1989: Young W L; Chien S
Effect of nimodipine on cerebral blood flow and metabolism in rats during hyperventilation.
Stroke; a journal of cerebral circulation 1989;20(2):275-80.
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1989: Chabanel A; Sung K L; Rapiejko J; Prchal J T; Palek J; Liu S C; Chien S
Viscoelastic properties of red cell membrane in hereditary elliptocytosis.
Blood 1989;73(2):592-5.
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1989: Kaperonis A A; Chien S
Effects of centrifugation on transmembrane water loss from normal and pathologic erythrocytes.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1989;190(2):174-8.
-
1989: Gallik S; Usami S; Jan K M; Chien S
Shear stress-induced detachment of human polymorphonuclear leukocytes from endothelial cell monolayers.
Biorheology 1989;26(4):823-34.
-
1989: Schmid-Schönbein G W; Chien S
Morphometry of human leukocyte granules.
Biorheology 1989;26(2):331-43.
-
1989: Lipowsky H H; Chien S
Role of leukocyte-endothelium adhesion in affecting recovery from ischemic episodes.
Annals of the New York Academy of Sciences 1989;565():308-15.
-
1988: Reinhart W H; Sung L P; Sung K L; Bernstein S E; Chien S
Impaired echinocytic transformation of ankyrin- and spectrin-deficient erythrocytes in mice.
American journal of hematology 1988;29(4):195-200.
-
1988: Lee M M; Schuessler G B; Lau K; Chien S
Effects of pressure on vesicle size, density, and distribution in the canine carotid arterial endothelium.
Journal of ultrastructure and molecular structure research 1988;101(2-3):236-42.
-
1988: Sung K L; Sung L A; Crimmins M; Burakoff S J; Chien S
Dynamic changes in viscoelastic properties in cytotoxic T-lymphocyte-mediated killing.
Journal of cell science 1988;91 ( Pt 2)():179-89.
-
1988: Lin S J; Jan K M; Schuessler G; Weinbaum S; Chien S
Enhanced macromolecular permeability of aortic endothelial cells in association with mitosis.
Atherosclerosis 1988;73(2-3):223-32.
-
1988: Seldin D W; Simchon S; Jan K M; Chien S; Alderson P O
Dependence of technetium-99m red blood cell labeling efficiency on red cell surface charge.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1988;29(10):1710-3.
-
1988: Sung K L; Dong C; Schmid-Schönbein G W; Chien S; Skalak R
Leukocyte relaxation properties.
Biophysical journal 1988;54(2):331-6.
-
1988: Simchon S; Jan K M; Chien S
Studies on sequestration of neuraminidase-treated red blood cells.
The American journal of physiology 1988;254(6 Pt 2):H1167-71.
-
1988: Reinhart W H; Chien S
Red cell vacuoles: their size and distribution under normal conditions and after splenectomy.
American journal of hematology 1988;27(4):265-71.
-
1988: Baldwin A L; Chien S
Effect of dextran 40 on endothelial binding and vesicle loading of ferritin in rabbit aorta.
Arteriosclerosis (Dallas, Tex.) 1988;8(2):140-6.
-
1988: Dong C; Skalak R; Sung K L; Schmid-Schönbein G W; Chien S
Passive deformation analysis of human leukocytes.
Journal of biomechanical engineering 1988;110(1):27-36.
-
1988: Lee M M; Schuessler G B; Chien S
Time-dependent effects of endotoxin on the ultrastructure of aortic endothelium.
Artery 1988;15(2):71-89.
-
1988: Schmid-Schönbein G W; Chien S
Morphometric studies on human leukocyte granules.
Advances in experimental medicine and biology 1988;242():99-109.
-
1988: Chien S; Lin S J; Weinbaum S; Lee M M; Jan K M
The role of arterial endothelial cell mitosis in macromolecular permeability.
Advances in experimental medicine and biology 1988;242():59-73.
-
1987: Chabanel A; Schachter D; Chien S
Increased rigidity of red blood cell membrane in young spontaneously hypertensive rats.
Hypertension 1987;10(6):603-7.
-
1987: Simchon S; Jan K M; Chien S
Influence of reduced red cell deformability on regional blood flow.
The American journal of physiology 1987;253(4 Pt 2):H898-903.
-
1987: Reinhart W H; Chabanel A; Vayo M; Chien S
Evaluation of a filter aspiration technique to determine membrane deformability.
The Journal of laboratory and clinical medicine 1987;110(4):483-94.
-
1987: Reinhart W H; Chien S
The time course of filtration test as a model for microvascular plugging by white cells and hardened red cells.
Microvascular research 1987;34(1):1-12.
-
1987: Skalak R; Soslowsky L; Schmalzer E; Impelluso T; Chien S
Theory of filtration of mixed blood suspensions.
Biorheology 1987;24(1):35-52.
-
1987: Chien S; Kaperonis A A; King R G; Lipowsky H H; Schmalzer E A; Sung L A; Sung K L; Usami S
Rheology of sickle cells and its role in microcirculatory dynamics.
Progress in clinical and biological research 1987;240():151-65.
-
1987: Chien S; Sung K L; Schmid-Schönbein G W; Skalak R; Schmalzer E A; Usami S
Rheology of leukocytes.
Annals of the New York Academy of Sciences 1987;516():333-47.
-
1987: Chien S
Molecular biology in biorheology.
Biorheology 1987;24(6):659-72.
-
1986: Chabanel A; Spiro A; Schachter D; Chien S
Some biophysical properties of the erythrocyte membrane in Duchenne muscular dystrophy.
Journal of the neurological sciences 1986;76(2-3):131-42.
-
1986: Simchon S; Chen R Y; Carlin R D; Fan F C; Jan K M; Chien S
Effects of blood viscosity on plasma renin activity and renal hemodynamics.
The American journal of physiology 1986;250(1 Pt 2):F40-6.
-
1986: Chien S
Blood rheology in myocardial infarction and hypertension.
Biorheology 1986;23(6):633-53.
-
1985: Sung K L; Freedman J; Chabanel A; Chien S
Effect of complement on the viscoelastic properties of human erythrocyte membrane.
British journal of haematology 1985;61(3):455-66.
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1985: Chabanel A; Abbott R E; Chien S; Schachter D
Effects of benzyl alcohol on erythrocyte shape, membrane hemileaflet fluidity and membrane viscoelasticity.
Biochimica et biophysica acta 1985;816(1):142-52.
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1984: Firrell J C; Lipowsky H H; Usami S; Chien S
Segmental and total microvascular resistances during hemorrhagic hypotension in rabbit omentum.
The American journal of physiology 1984;247(3 Pt 2):H361-70.
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1984: Tözeren A; Skalak R; Fedorciw B; Sung K L; Chien S
Constitutive equations of erythrocyte membrane incorporating evolving preferred configuration.
Biophysical journal 1984;45(3):541-9.
-
1984: Chen R Y; Fan F C; Schuessler G B; Simchon S; Kim S; Chien S
Regional cerebral blood flow and oxygen consumption of the canine brain during hemorrhagic hypotension.
Stroke; a journal of cerebral circulation 1984;15(2):343-50.
-
1984: Chien S; Schmid-Schönbein G W; Sung K L; Schmalzer E A; Skalak R
Viscoelastic properties of leukocytes.
Kroc Foundation series 1984;16():19-51.
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1983: Chabanel A; Flamm M; Sung K L; Lee M M; Schachter D; Chien S
Influence of cholesterol content on red cell membrane viscoelasticity and fluidity.
Biophysical journal 1983;44(2):171-6.
-
1983: Chen R Y; Fan F C; Schuessler G B; Usami S; Chien S
Effects of sphere size and injection site on regional cerebral blood flow measurements.
Stroke; a journal of cerebral circulation 1983;14(5):769-76.
-
1983: Handley D A; Chien S; Arbeeny C M
Ultrastructure of hepatic cholesterol crystals in the hypercholesterolemic - diabetic rat.
Pathology, research and practice 1983;177(1):13-21.
-
1983: Handley D A; Arbeeny C M; Chien S
Sinusoidal endothelial endocytosis of low density lipoprotein-gold conjugates in perfused livers of ethinyl-estradiol treated rats.
European journal of cell biology 1983;30(2):266-71.
-
1983: Skalak R; Impelluso T; Schmalzer E A; Chien S
Theoretical modeling of filtration of blood cell suspensions.
Biorheology 1983;20(1):41-56.
-
1983: Schmalzer E A; Skalak R; Usami S; Vayo M; Chien S
Influence of red cell concentration on filtration of blood cell suspensions.
Biorheology 1983;20(1):29-40.
-
1983: Chien S; Schmalzer E A; Lee M M; Impelluso T; Skalak R
Role of white blood cells in filtration of blood cell suspensions.
Biorheology 1983;20(1):11-27.
-
1982: Tözeren A; Skalak R; Sung K L; Chien S
Viscoelastic behavior of erythrocyte membrane.
Biophysical journal 1982;39(1):23-32.
-
1982: Chen R Y; Fan F C; Schuessler G B; Chien S
Baroreflex control of heart rate in humans during nitroprusside-induced hypotension.
The American journal of physiology 1982;243(1):R18-24.
-
1982: Chen R Y; Matteo R S; Fan F C; Schuessler G B; Chien S
Resetting of baroreflex sensitivity after induced hypotension.
Anesthesiology 1982;56(1):29-35.
-
1981: Fan F C; Chen R Y; Chien S; Correll J W
Bypass blood flow during carotid endarterectomy.
Anesthesiology 1981;55(3):305-10.
-
1981: Handley D A; Arbeeny C M; Eder H A; Chien S
Hepatic binding and internalization of low density lipoprotein-gold conjugates in rats treated with 17 alpha-ethinylestradiol.
The Journal of cell biology 1981;90(3):778-87.
-
1981: Handley D A; Arbeeny C M; Witte L D; Chien S
Colloidal gold--low density lipoprotein conjugates as membrane receptor probes.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(1):368-71.
-
1980: Fan F C; Kim S; Simchon S; Chen R Y; Schuessler G B; Chien S
Effects of sodium nitroprusside on systemic and regional hemodynamics and oxygen utilization in the dog.
Anesthesiology 1980;53(2):113-20.
-
1980: Fan F C; Chen R Y; Schuessler G B; Chien S
Effects of hematocrit variations on regional hemodynamics and oxygen transport in the dog.
The American journal of physiology 1980;238(4):H545-22.
-
1980: Kim S; Fan F; Chen R Y; Simchon S; Schuessler G B; Chien S
Symposium: 3. Effects of changes in systemic hemodynamic parameters on pulpal hemodynamics.
Journal of endodontics 1980;6(1):394-9.
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