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Michele Chiesi

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Danilo Guerini; Elisabetta Prati; Urvi Desai; Hanspeter Nick; Rolf Flammer; Stephan Grüninger; Frederic Cumin; Machael Kaleko; Sheila Connelly; Michele Chiesi
Uncoupling of protein-3 induces an uncontrolled uncoupling of mitochondria after expression in muscle derived L6 cells.
Michele Chiesi; C Huppertz; KG Hofbauer
Pharmacotherapy of obesity: targets and perspectives.
Heinrich Rueeger; Pascal Rigollier; Yasuchika Yamaguchi; Tibur Schmidlin; Walter Schilling; L Criscione; Steven Whitebread; Michele Chiesi; Mary Walker; Dale Dhanoa; Imadul Islam; J Zhang; Charles Gluchowski
Design, synthesis and SAR of a series of 2-substituted 4-amino-quinazoline neuropeptide Y Y5 receptor antagonists.

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All Publications

2002: Danilo Guerini; Elisabetta Prati; Urvi Desai; Hanspeter Nick; Rolf Flammer; Stephan Grüninger; Frederic Cumin; Machael Kaleko; Sheila Connelly; Michele Chiesi
Uncoupling of protein-3 induces an uncontrolled uncoupling of mitochondria after expression in muscle derived L6 cells.
European journal of biochemistry / FEBS 2002;269(5):1373-81.
2001: Michele Chiesi; C Huppertz; KG Hofbauer
Pharmacotherapy of obesity: targets and perspectives.
Trends in pharmacological sciences 2001;22(5):247-54.
2000: Heinrich Rueeger; Pascal Rigollier; Yasuchika Yamaguchi; Tibur Schmidlin; Walter Schilling; L Criscione; Steven Whitebread; Michele Chiesi; Mary Walker; Dale Dhanoa; Imadul Islam; J Zhang; Charles Gluchowski
Design, synthesis and SAR of a series of 2-substituted 4-amino-quinazoline neuropeptide Y Y5 receptor antagonists.
Bioorganic & medicinal chemistry letters 2000;10(11):1175-9.
2000: Benoit Pierrat; M Ito; W Hinz; Marjo Simonen; D Erdmann; Michele Chiesi; Jutta Heim
Uncoupling proteins 2 and 3 interact with members of the 14.3.3 family.
European journal of biochemistry / FEBS 2000;267(9):2680-7.
1999: W Hinz; Stephan Grüninger; A De Pover; Michele Chiesi
Properties of the human long and short isoforms of the uncoupling protein-3 expressed in yeast cells.
FEBS letters 1999;462(3):411-5.
1999: L Brunner; Steven Whitebread; I Leconte; Alain Stricker-Krongrad; Frederic Cumin; Michele Chiesi; N Levens
A peptide leptin antagonist reduces food intake in rodents.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1999;23(5):463-9.
1999: W Hinz; B Faller; Stephan Grüninger; P Gazzotti; Michele Chiesi
Recombinant human uncoupling protein-3 increases thermogenesis in yeast cells.
FEBS letters 1999;448(1):57-61.
1998: L Criscione; Pascal Rigollier; C Batzl-Hartmann; H Rüeger; Alain Stricker-Krongrad; P Wyss; L Brunner; Steven Whitebread; Yasuchika Yamaguchi; Christophe Gerald; R O Heurich; Mary Walker; Michele Chiesi; Walter Schilling; KG Hofbauer; N Levens
Food intake in free-feeding and energy-deprived lean rats is mediated by the neuropeptide Y5 receptor.
The Journal of clinical investigation 1998;102(12):2136-45.
1997: L Brunner; Hanspeter Nick; Frederic Cumin; Michele Chiesi; Hans-Peter Baum; Steven Whitebread; Alain Stricker-Krongrad; N Levens
Leptin is a physiologically important regulator of food intake.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1997;21(12):1152-60.
1997: B Löllmann; Stephan Grüninger; Alain Stricker-Krongrad; Michele Chiesi
Detection and quantification of the leptin receptor splice variants Ob-Ra, b, and, e in different mouse tissues.
Biochemical and biophysical research communications 1997;238(2):648-52.
1996: J W Herzig; Michele Chiesi; H Depersin; Stephan Grüninger; G Hasenfuss; R Kubalek; T Leutert; Burkert Pieske; K Pioch; P Wenk; C Holubarsch
Ca2+ sensitization in idiopathic dilated human myocardium. Differential in vitro effects of (+)-(5-methyl-6-phenyl)-1,3,5,6-tetrahydro-3,6-methano-1,5-benzodiazoci ne-2,4-dione, a novel purely Ca2+sensitizing agent, and (+)-5-(1-(3,4-dimethoxybenzoyl)-1,2,3,4-tetrahydroquinolin-6-yl)-6-meth yl-3, 6-dihydro-2H-1,3,4-thiadiazin-2-one on skinned fibres and isolated ventricular strips.
Arzneimittel-Forschung 1996;46(6):586-93.
1996: J Rentsch; Michele Chiesi
Regulation of ob gene mRNA levels in cultured adipocytes.
FEBS letters 1996;379(1):55-9.
1995: Federico Bennardini; Antonella Mattana; E P Nossai; M Mignano; Flavia Franconi; C Juliano; Luigi Sciola; Proto Pippia; Michele Chiesi
Kinetic changes of alpha B crystallin expression in neoplastic cells and syngeneic rat fibroblasts at various subculture stages.
Molecular and cellular biochemistry 1995;152(1):23-30.
1995: J Rentsch; N Levens; Michele Chiesi
Recombinant ob-gene product reduces food intake in fasted mice.
Biochemical and biophysical research communications 1995;214(1):131-6.
1995: Federico Bennardini; C Juliano; Dino Benetti; M Mian; Michele Chiesi; Antonella Mattana; Flavia Franconi
Alpha B crystallin is constitutively expressed in cultures of bovine articular chondrocytes.
Biochemical and biophysical research communications 1995;208(2):742-7.
1995: Michele Chiesi; R Schwaller
Inhibition of constitutive endothelial NO-synthase activity by tannin and quercetin.
Biochemical pharmacology 1995;49(4):495-501.
1995: W Lesniak; C Schaefer; S Grueninger; Michele Chiesi
Effect of alpha adrenergic stimulation and carnitine palmitoyl transferase I inhibition on hypertrophying adult rat cardiomyocytes in culture.
Molecular and cellular biochemistry 1995;142(1):25-34.
1994: W Lesniak; N Modyanov; Michele Chiesi
Reversible inactivation of the sarcoplasmic reticulum Ca(2+)-ATPase coupled to rearrangement of cytoplasmic protein domains as revealed by changes in trypsinization pattern.
Biochemistry 1994;33(46):13678-83.
1994: Michele Chiesi; R Schwaller
Reversal of phospholamban-induced inhibition of cardiac sarcoplasmic reticulum Ca(2+)-ATPase by tannin.
Biochemical and biophysical research communications 1994;202(3):1668-73.
1994: Michele Chiesi; A Wrzosek; S Grueninger
The role of the sarcoplasmic reticulum in various types of cardiomyocytes.
Molecular and cellular biochemistry 1994;130(2):159-71.
1993: T Vorherr; A Wrzosek; Michele Chiesi; Ernesto Carafoli
Total synthesis and functional properties of the membrane-intrinsic protein phospholamban.
Protein science : a publication of the Protein Society 1993;2(3):339-47.
1992: Federico Bennardini; A Wrzosek; Michele Chiesi
Alpha B-crystallin in cardiac tissue. Association with actin and desmin filaments.
Circulation research 1992;71(2):288-94.
1992: A Wrzosek; H Schneider; S Grueninger; Michele Chiesi
Effect of thapsigargin on cardiac muscle cells.
Cell calcium 1992;13(5):281-92.
1992: T Vorherr; Michele Chiesi; R Schwaller; Ernesto Carafoli
Regulation of the calcium ion pump of sarcoplasmic reticulum: reversible inhibition by phospholamban and by the calmodulin binding domain of the plasma membrane calcium ion pump.
Biochemistry 1992;31(2):371-6.
1992: Michele Chiesi; Federico Bennardini
Determination of alpha B crystallin aggregation: a new alternative method to assess ischemic damage of the heart.
Basic research in cardiology 1992;87(1):38-46.
1991: Michele Chiesi; T Vorherr; R Falchetto; C Waelchli; Ernesto Carafoli
Phospholamban is related to the autoinhibitory domain of the plasma membrane Ca(2+)-pumping ATPase.
Biochemistry 1991;30(32):7978-83.
1990: S Longoni; P James; Michele Chiesi
Cardiac alpha-crystallin. I. Isolation and identification.
Molecular and cellular biochemistry 1990;99(1):113-20.
1990: K Baltensperger; Michele Chiesi; Ernesto Carafoli
Substrates of cGMP kinase in vascular smooth muscle and their role in the relaxation process.
Biochemistry 1990;29(41):9753-60.
1990: Michele Chiesi; S Longoni; U Limbruno
Cardiac alpha-crystallin. III. Involvement during heart ischemia.
Molecular and cellular biochemistry 1990;97(2):129-36.
1990: S Longoni; S Lattonen; G Bullock; Michele Chiesi
Cardiac alpha-crystallin. II. Intracellular localization.
Molecular and cellular biochemistry 1990;97(2):121-8.
1989: L Criscione; H Thomann; C Rodriguez; C Eglème; Michele Chiesi
Blockade of endothelin-induced contractions by dichlorobenzamil: mechanism of action.
Biochemical and biophysical research communications 1989;163(1):247-54.
1989: P Erne; Michele Chiesi; S Longoni; J Fulbright; Kent Hermsmeyer
Relaxation of rat vascular muscle by peripheral benzodiazepine modulators.
The Journal of clinical investigation 1989;84(2):493-8.
1989: Michele Chiesi; R Schwaller
Involvement of electrostatic phenomena in phospholamban-induced stimulation of Ca uptake into cardiac sarcoplasmic reticulum.
FEBS letters 1989;244(1):241-4.
1989: G Calviello; Michele Chiesi
Rapid kinetic analysis of the calcium-release channels of skeletal muscle sarcoplasmic reticulum: the effect of inhibitors.
Biochemistry 1989;28(3):1301-6.
1988: Michele Chiesi; R Schwaller; K Eichenberger
Structural dependency of the inhibitory action of benzodiazepines and related compounds on the mitochondrial Na+-Ca2+ exchanger.
Biochemical pharmacology 1988;37(22):4399-403.
1988: J Gasser; P Paganetti; Ernesto Carafoli; Michele Chiesi
Heterogeneous distribution of calmodulin- and cAMP-dependent regulation of Ca2+ uptake in cardiac sarcoplasmic reticulum subfractions.
European journal of biochemistry / FEBS 1988;176(3):535-41.
1988: Michele Chiesi; R Schwaller; G Calviello
Inhibition of rapid Ca-release from isolated skeletal and cardiac sarcoplasmic reticulum (SR) membranes.
Biochemical and biophysical research communications 1988;154(1):1-8.
1988: K Baltensperger; Ernesto Carafoli; Michele Chiesi
The Ca2+-pumping ATPase and the major substrates of the cGMP-dependent protein kinase in smooth muscle sarcolemma are distinct entities.
European journal of biochemistry / FEBS 1988;172(1):7-16.
1987: Michele Chiesi; H Rogg; K Eichenberger; P Gazzotti; E Carafoli
Stereospecific action of diltiazem on the mitochondrial Na-Ca exchange system and on sarcolemmal Ca-channels.
Biochemical pharmacology 1987;36(17):2735-40.
1987: Michele Chiesi; R Schwaller
Characterization of heart cytosolic proteins capable of modulating calcium uptake by the sarcoplasmic reticulum. 2. Identification of actin isoforms with inhibitory activity.
European journal of biochemistry / FEBS 1987;162(2):371-7.
1984: Michele Chiesi; J Gasser; Ernesto Carafoli
Properties of the Ca-pumping ATPase of sarcoplasmic reticulum from vascular smooth muscle.
Biochemical and biophysical research communications 1984;124(3):797-806.
1983: Michele Chiesi; J Gasser; Ernesto Carafoli
Phospholamban of cardiac sarcoplasmic reticulum consists of two functionally distinct proteolipids.
FEBS letters 1983;160(1-2):61-6.