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Geoffrey Childs

Research Profile

Chemicals & Drugs

Devices

Oligonucleotide Array Sequence Analysis

Phenomena

Nucleic Acid Hybridization

Procedures

Physiology

Genes & Molecular Sequences

Concepts & Ideas

Molecular Sequence Data

Disorders

Living Beings

Mouse

Anatomy

Nonmammalian Embryo

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Publications

TOP 3
Nicolas F Schlecht; Richard V Smith; Paul A Reynolds; Thomas J Belbin; Margaret Brandwein-Gensler; Darcy Broughel; Geoffrey Childs; Frank J Gunn-Moore; Thomas Harris; Nicole Kawachi; Christian E. Keller; Juan Lin; Michael B Prystowsky
Cytoplasmic ezrin and moesin correlate with poor survival in head and neck squamous cell carcinoma.
Geoffrey Childs; Jeffrey E Segall
Twists and turns of invasion.
Thomas M Harris; Lizandra Jimenez; Nicole Kawachi; Christian E. Keller; Olivier D Loudig; Michael B Prystowsky; Andrew Ramnauth; Nicolas F Schlecht; Jeffrey E Segall; Richard V Smith; Thomas J Belbin; Jing Chen; Jian-Bing Fan; Geoffrey Childs
Low-level expression of miR-375 correlates with poor outcome and metastasis while altering the invasive properties of head and neck squamous cell carcinomas.

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All Publications

2012: Nicolas F Schlecht; Richard V Smith; Paul A Reynolds; Thomas J Belbin; Margaret Brandwein-Gensler; Darcy Broughel; Geoffrey Childs; Frank J Gunn-Moore; Thomas Harris; Nicole Kawachi; Christian E. Keller; Juan Lin; Michael B Prystowsky
Cytoplasmic ezrin and moesin correlate with poor survival in head and neck squamous cell carcinoma.
Head and neck pathology 2012;6(2):232-43.
2012: Geoffrey Childs; Jeffrey E Segall
Twists and turns of invasion.
Nature cell biology 2012;14(4):337-9.
2012: Thomas M Harris; Lizandra Jimenez; Nicole Kawachi; Christian E. Keller; Olivier D Loudig; Michael B Prystowsky; Andrew Ramnauth; Nicolas F Schlecht; Jeffrey E Segall; Richard V Smith; Thomas J Belbin; Jing Chen; Jian-Bing Fan; Geoffrey Childs
Low-level expression of miR-375 correlates with poor outcome and metastasis while altering the invasive properties of head and neck squamous cell carcinomas.
The American journal of pathology 2012;180(3):917-28.
2012: Orsi Giricz; Paraic Kenny; Christina Liu; Andrew Ramnauth; Paul A Reynolds; Thomas E Rohan; Nella Shapiro; Lesley Stead; Tao Wang; Geoffrey Childs; Susan Fineberg; Olivier D Loudig
Hsa-miR-375 is differentially expressed during breast lobular neoplasia and promotes loss of mammary acinar polarity.
The Journal of pathology 2012;226(1):108-19.
2011: Roberto A Lleras; Leslie R Adrien; Richard V Smith; Benjamin Brown; Naheed Jivraj; Christopher Keller; Cathy Sarta; Nicolas F Schlecht; Thomas M Harris; Geoffrey Childs; Michael B Prystowsky; Thomas J Belbin
Hypermethylation of a cluster of Krüppel-type zinc finger protein genes on chromosome 19q13 in oropharyngeal squamous cell carcinoma.
The American journal of pathology 2011;178(5):1965-74.
2009: Michael B Prystowsky; Alfred Adomako; Richard V Smith; Nicole Kawachi; Wendy McKimpson; Peter Atadja; Quan Chen; Nicolas F Schlecht; Joanna L Parish; Geoffrey Childs; Thomas J Belbin
The histone deacetylase inhibitor LBH589 inhibits expression of mitotic genes causing G2/M arrest and cell death in head and neck squamous cell carcinoma cell lines.
The Journal of pathology 2009;218(4):467-77.
2009: Geoffrey Childs; Melissa Fazzari; Gloria Kung; Nicole Kawachi; Margaret Brandwein-Gensler; Michael McLemore; Quan Chen; Robert D Burk; Richard V Smith; Michael B Prystowsky; Thomas J Belbin; Nicolas F Schlecht
Low-level expression of microRNAs let-7d and miR-205 are prognostic markers of head and neck squamous cell carcinoma.
The American journal of pathology 2009;174(3):736-45.
2008: Thomas J Belbin; Nicolas F Schlecht; Richard V Smith; Leslie R Adrien; Nicole Kawachi; Margaret Brandwein-Gensler; Aviv Bergman; Quan Chen; Geoffrey Childs; Michael B Prystowsky
Site-specific molecular signatures predict aggressive disease in HNSCC.
Head and neck pathology 2008;2(4):243-56.
2007: Nicolas F Schlecht; Robert D Burk; L Adrien; A Dunne; Nicole Kawachi; C Sarta; Quan Chen; Margaret Brandwein-Gensler; Michael B Prystowsky; Geoffrey Childs; Richard V Smith; Thomas J Belbin
Gene expression profiles in HPV-infected head and neck cancer.
The Journal of pathology 2007;213(3):283-93.
2007: Thomas J Belbin; Aviv Bergman; Margaret Brandwein-Gensler; Quan Chen; Geoffrey Childs; Madhur Garg; Missak Haigentz; Ruth Hogue Angeletti; Renee M Moadel; Abdissa Negassa; Randall P Owen; Michael B Prystowsky; Bradley Schiff; Nicolas F Schlecht; Keivan Shifteh; Richard V Smith; Xin Zheng
Head and neck cancer: reduce and integrate for optimal outcome.
Cytogenetic and genome research 2007;118(2-4):92-109.
2007: Olivier D Loudig; Ekaterina Milova; Margaret Brandwein-Gensler; Aldo Massimi; Thomas J Belbin; Geoffrey Childs; Robert H Singer; Thomas E Rohan; Michael B Prystowsky
Molecular restoration of archived transcriptional profiles by complementary-template reverse-transcription (CT-RT).
Nucleic acids research 2007;35(15):e94.
2006: Rashna Madan; Margaret Brandwein-Gensler; Nicolas F Schlecht; Kristin Elias; Eleanor Gorbovitsky; Thomas J Belbin; Radma Mahmood; Dwayne Breining; Hong Qian; Geoffrey Childs; Joseph Locker; Richard V Smith; Missak Haigentz; Frank J Gunn-Moore; Michael B Prystowsky
Differential tissue and subcellular expressionof ERM proteins in normal and malignant tissues: cytoplasmic ezrin expression has prognostic signficance for head and neck squamous cell carcinoma.
Head & neck 2006;28(11):1018-27.
2006: Richard V Smith; Nicolas F Schlecht; Geoffrey Childs; Michael B Prystowsky; Thomas J Belbin
Pilot study of mucosal genetic differences in early smokers and nonsmokers.
The Laryngoscope 2006;116(8):1375-9.
2006: Christopher A Davis; Michael Haberland; Michael A Arnold; Lillian B Sutherland; Oliver G McDonald; James A Richardson; Geoffrey Childs; Stephen Harris; Gary K Owens; Eric N Olson
PRISM/PRDM6, a transcriptional repressor that promotes the proliferative gene program in smooth muscle cells.
Molecular and cellular biology 2006;26(7):2626-36.
2006: L R Adrien; Nicolas F Schlecht; Nicole Kawachi; Richard V Smith; Margaret Brandwein-Gensler; Aldo Massimi; Sheng Chen; Michael B Prystowsky; Geoffrey Childs; Thomas J Belbin
Classification of DNA methylation patterns in tumor cell genomes using a CpG island microarray.
Cytogenetic and genome research 2006;114(1):16-23.
2005: Hailing Liu; Thomas M Harris; Hyung H Kim; Geoffrey Childs
Cardiac myocyte differentiation: the Nkx2.5 and Cripto target genes in P19 clone 6 cells.
Functional & integrative genomics 2005;5(4):218-39.
2005: Osamu Nakagawa; Michael Arnold; Masayo Nakagawa; Hideaki Hamada; John M Shelton; Hajime Kusano; Thomas M Harris; Geoffrey Childs; Kevin P Campbell; James A Richardson; Ichizo Nishino; Eric N Olson
Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2.
Genes & development 2005;19(17):2066-77.
2005: Joseph A Sparano; Melissa Fazzari; Geoffrey Childs
Clinical application of molecular profiling in breast cancer.
Future oncology (London, England) 2005;1(4):485-96.
2005: Jeremy P Segal; Nancy R Stallings; Charlotte E Lee; Liping Zhao; Nicholas D Socci; Agnes Viale; Thomas M Harris; Marcelo B Soares; Geoffrey Childs; Joel K Elmquist; Keith L Parker; Jeffrey M Friedman
Use of laser-capture microdissection for the identification of marker genes for the ventromedial hypothalamic nucleus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(16):4181-8.
2005: Thomas J Belbin; Bhuvanesh Singh; Richard V Smith; Nicholas D Socci; Volkert B Wreesmann; Marta Sanchez-Carbayo; Jessica Masterson; Snehal G Patel; Carlos Cordon-Cardo; Michael B Prystowsky; Geoffrey Childs
Molecular profiling of tumor progression in head and neck cancer.
Archives of otolaryngology--head & neck surgery 2005;131(1):10-8.
2004: Q Jackie Cao; Thomas J Belbin; Nicholas D Socci; Raluca Balan; Michael B Prystowsky; Geoffrey Childs; Joan G Jones
Distinctive gene expression profiles by cDNA microarrays in endometrioid and serous carcinomas of the endometrium.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2004;23(4):321-9.
2004: Volkert B Wreesmann; Elizabeth Sieczka; Nicholas D Socci; Michael Hezel; Thomas J Belbin; Geoffrey Childs; Snehal G Patel; Kepal N Patel; Giovanni Tallini; Michael B Prystowsky; Ashok R Shaha; Dennis H Kraus; Jatin P Shah; Pulivarthi H Rao; Ronald A Ghossein; Bhuvanesh Singh
Genome-wide profiling of papillary thyroid cancer identifies MUC1 as an independent prognostic marker.
Cancer research 2004;64(11):3780-9.
2004: Thomas J Belbin; John Gaspar; Missak Haigentz; Roman Perez-Soler; Steven M Keller; Michael B Prystowsky; Geoffrey Childs; Nicholas D Socci
Indirect measurements of differential gene expression with cDNA microarrays.
BioTechniques 2004;36(2):310-4.
2004: Raymond B Birge; Scott Wadsworth; R Akakura; H Abeysinghe; R Kanojia; Mark J Macielag; Julie Desbarats; M Escalante; K Singh; S Sundarababu; K Parris; Geoffrey Childs; Avery August; John Siekierka; David E Weinstein
A role for schwann cells in the neuroregenerative effects of a non-immunosuppressive fk506 derivative, jnj460.
Neuroscience 2004;124(2):351-66.
2003: Marta Sanchez-Carbayo; Nicholas D Socci; Juan Jose Lozano ; Wentian Li; Elizabeth Charytonowicz; Thomas J Belbin; Michael B Prystowsky; Angel R Ortiz; Geoffrey Childs; Carlos Cordon-Cardo
Gene discovery in bladder cancer progression using cDNA microarrays.
The American journal of pathology 2003;163(2):505-16.
2003: Marta Sanchez-Carbayo; Thomas J Belbin; Katia Scotlandi; Michael B Prystowsky; Nicola Baldini; Geoffrey Childs; Carlos Cordon-Cardo
Expression profiling of osteosarcoma cells transfected with MDR1 and NEO genes: regulation of cell adhesion, apoptosis, and tumor suppression-related genes.
Laboratory investigation; a journal of technical methods and pathology 2003;83(4):507-17.
2002: Marta Sanchez-Carbayo; Nicholas D Socci; Elizabeth Charytonowicz; Minglan Lu; Michael B Prystowsky; Geoffrey Childs; Carlos Cordon-Cardo
Molecular profiling of bladder cancer using cDNA microarrays: defining histogenesis and biological phenotypes.
Cancer research 2002;62(23):6973-80.
2002: Chong H Shin; Zhi-Ping Liu; Passier Robert; Chun Li Zhang; Dazhi Wang; Thomas M Harris; Hiroyuki Yamagishi; James A Richardson; Geoffrey Childs; Eric N Olson
Modulation of cardiac growth and development by HOP, an unusual homeodomain protein.
Cell 2002;110(6):725-35.
2002: Thomas M Harris; Geoffrey Childs
Global gene expression patterns during differentiation of F9 embryonal carcinoma cells into parietal endoderm.
Functional & integrative genomics 2002;2(3):105-19.
2002: Yi Wei; Thomas M Harris; Geoffrey Childs
Global gene expression patterns during neural differentiation of P19 embryonic carcinoma cells.
Differentiation; research in biological diversity 2002;70(4-5):204-19.
2002: Thomas J Belbin; Bhuvanesh Singh; Ilana Barber; Nicholas D Socci; Bruce Wenig; Richard V Smith; Michael B Prystowsky; Geoffrey Childs
Molecular classification of head and neck squamous cell carcinoma using cDNA microarrays.
Cancer research 2002;62(4):1184-90.
2002: Chang-Fu Peng; Yi Wei; Jeffrey M. Levsky; Thomas V McDonald; Geoffrey Childs; Richard N Kitsis
Microarray analysis of global changes in gene expression during cardiac myocyte differentiation.
Physiological genomics 2002;9(3):145-55.
2001: J Gonzalez; Thomas M Harris; Geoffrey Childs; Michael B Prystowsky
Rapamycin blocks IL-2-driven T cell cycle progression while preserving T cell survival.
Blood cells, molecules & diseases 2001;27(3):572-85.
2000: Thomas M Harris; Aldo Massimi; Geoffrey Childs
Injecting new ideas into microarray printing.
Nature biotechnology 2000;18(4):384-5.
1999: M L Benuck; Z Li; Geoffrey Childs
Mutations that increase acidity enhance the transcriptional activity of the glutamine-rich activation domain in stage-specific activator protein.
The Journal of biological chemistry 1999;274(36):25419-25.
1999: Z Li; Geoffrey Childs
Temporal activation of the sea urchin late H1 gene requires stage-specific phosphorylation of the embryonic transcription factor SSAP.
Molecular and cellular biology 1999;19(5):3684-95.
1999: Vivian G Cheung; Michael Morley; F Aguilar; Aldo Massimi; Raju Kucherlapati; Geoffrey Childs
Making and reading microarrays.
Nature genetics 1999;21(1 Suppl):15-9.
1998: L Edelmann; L Zheng; Z F Wang; William F Marzluff; G M Wessel; Geoffrey Childs
The TATA binding protein in the sea urchin embryo is maternally derived.
Developmental biology 1998;204(1):293-304.
1998: D Zhang; A J Paley; Geoffrey Childs
The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription.
The Journal of biological chemistry 1998;273(29):18086-91.
1998: D Zhang; Geoffrey Childs
Human ZFM1 protein is a transcriptional repressor that interacts with the transcription activation domain of stage-specific activator protein.
The Journal of biological chemistry 1998;273(12):6868-77.
1998: L Edelmann; Geoffrey Childs
Multiple SSAP binding sites constitute the stage-specific enhancer of the sea urchin late H1beta gene.
Gene expression 1998;7(3):133-47.
1996: J DeFalco; Geoffrey Childs
The embryonic transcription factor stage specific activator protein contains a potent bipartite activation domain that interacts with several RNA polymerase II basal transcription factors.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(12):5802-7.
1995: Daniel J DeAngelo; J DeFalco; L Rybacki; Geoffrey Childs
The embryonic enhancer-binding protein SSAP contains a novel DNA-binding domain which has homology to several RNA-binding proteins.
Molecular and cellular biology 1995;15(3):1254-64.
1993: Z Li; S R Kalasapudi; Geoffrey Childs
Isolation and characterization of cDNAs encoding the sea urchin (Strongylocentrotus purpuratus) homologue of the CCAAT binding protein NF-Y A subunit.
Nucleic acids research 1993;21(19):4639.
1993: Daniel J DeAngelo; J DeFalco; Geoffrey Childs
Purification and characterization of the stage-specific embryonic enhancer-binding protein SSAP-1.
Molecular and cellular biology 1993;13(3):1746-58.
1993: H Fei; Geoffrey Childs
Temporal embryonic expression of the sea urchin early H1 gene is controlled by sequences immediately upstream and downstream of the TATA element.
Developmental biology 1993;155(2):383-95.
1990: M Sanicola; S Ward; Geoffrey Childs; Scott W Emmons
Identification of a Caenorhabditis elegans histone H1 gene family. Characterization of a family member containing an intron and encoding a poly(A)+ mRNA.
Journal of molecular biology 1990;212(2):259-68.
1989: M DiLiberto; Z C Lai; H Fei; Geoffrey Childs
Developmental control of promoter-specific factors responsible for the embryonic activation and inactivation of the sea urchin early histone H3 gene.
Genes & development 1989;3(7):973-85.
1989: R Kraft; S T Ishizaka; S A Okenquist; Geoffrey Childs; F Lilly; Jack Lenz
Absence of mouse mammary tumor virus proviral amplification in chemically induced lymphomas of RF/J mice.
Journal of virology 1989;63(7):3200-4.
1989: Z C Lai; Daniel J DeAngelo; M DiLiberto; Geoffrey Childs
An embryonic enhancer determines the temporal activation of a sea urchin late H1 gene.
Molecular and cellular biology 1989;9(6):2315-21.
1989: S B Roberts; Scott W Emmons; Geoffrey Childs
Nucleotide sequences of Caenorhabditis elegans core histone genes. Genes for different histone classes share common flanking sequence elements.
Journal of molecular biology 1989;206(4):567-77.
1989: Dominic L Poccia; T Lieber; Geoffrey Childs
Histone gene expression during sea urchin spermatogenesis: an in situ hybridization study.
Molecular reproduction and development 1989;1(3):219-29.
1988: T Lieber; Lynne M Angerer; Robert Clifford Angerer; Geoffrey Childs
A histone H1 protein in sea urchins is encoded by a poly(A)+ mRNA.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(12):4123-7.
1988: Z C Lai; Geoffrey Childs
Characterization of the structure and transcriptional patterns of the gene encoding the late histone subtype H1-beta of the sea urchin Strongylocentrotus purpuratus.
Molecular and cellular biology 1988;8(4):1842-4.
1988: Z C Lai; Robert E Maxson; Geoffrey Childs
Both basal and ontogenic promoter elements affect the timing and level of expression of a sea urchin H1 gene during early embryogenesis.
Genes & development 1988;2(2):173-83.
1987: S B Roberts; M Sanicola; Scott W Emmons; Geoffrey Childs
Molecular characterization of the histone gene family of Caenorhabditis elegans.
Journal of molecular biology 1987;196(1):27-38.
1987: J A Knowles; Z C Lai; Geoffrey Childs
Isolation, characterization, and expression of the gene encoding the late histone subtype H1-gamma of the sea urchin Strongylocentrotus purpuratus.
Molecular and cellular biology 1987;7(1):478-85.
1986: Z Lai; T Lieber; Geoffrey Childs
The nucleotide sequence of the gene encoding the sperm specific histone subtype H2B-1 from the sea urchin Strongylocentrotus purpuratus.
Nucleic acids research 1986;14(22):9218.
1986: J A Knowles; Geoffrey Childs
Comparison of the late H1 histone genes of the sea urchins Lytechinus pictus and Strongelocentrotus purpuratus.
Nucleic acids research 1986;14(20):8121-33.
1986: Z C Lai; Geoffrey Childs
Isolation and characterization of the gene encoding the testis specific histone protein H2B-2 from the sea urchin Lytechinus pictus.
Nucleic acids research 1986;14(17):6845-56.
1986: T Lieber; K Weisser; Geoffrey Childs
Analysis of histone gene expression in adult tissues of the sea urchins Strongylocentrotus purpuratus and Lytechinus pictus: tissue-specific expression of sperm histone genes.
Molecular and cellular biology 1986;6(7):2602-12.
1985: Jeffrey M Chinsky; F Lilly; Geoffrey Childs
Comparison of chemically induced and spontaneous murine thymic lymphomas in RF and AKR mice: differential expression of c-myc and c-myb.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(2):565-9.
1985: Jeffrey M Chinsky; M M Goodenow; M Jackson; F Lilly; L Leinwand; Geoffrey Childs
Comparison of endogenous murine leukemia virus proviral organization and RNA expression in 3-methylcholanthrene-induced and spontaneous thymic lymphomas in RF and AKR mice.
Journal of virology 1985;53(1):94-9.
1984: C A Holt; Geoffrey Childs
A new family of tandem repetitive early histone genes in the sea urchin Lytechinus pictus: evidence for concerted evolution within tandem arrays.
Nucleic acids research 1984;12(16):6455-71.
1984: S B Roberts; K E Weisser; Geoffrey Childs
Sequence comparisons of non-allelic late histone genes and their early stage counterparts. Evidence for gene conversion within the sea urchin late stage gene family.
Journal of molecular biology 1984;174(4):647-62.
1984: J A Knowles; Geoffrey Childs
Temporal expression of late histone messenger RNA in the sea urchin Lytechinus pictus.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(8):2411-5.
1983: Dan A Liebermann; B Hoffman-Liebermann; J Weinthal; Geoffrey Childs; Robert E Maxson; A Mauron; S N Cohen; Larry Kedes
An unusual transposon with long terminal inverted repeats in the sea urchin Strongylocentrotus purpuratus.
Nature 1983;306(5941):342-7.
1983: Robert E Maxson; T Mohun; G Gormezano; Geoffrey Childs; Larry Kedes
Distinct organizations and patterns of expression of early and late histone gene sets in the sea urchin.
Nature 1983;301(5896):120-5.
1982: Geoffrey Childs; C Nocente-McGrath; T Lieber; C Holt; J A Knowles
Sea urchin (lytechinus pictus) late-stage histone H3 and H4 genes: characterization and mapping of a clustered but nontandemly linked multigene family.
Cell 1982;31(2 Pt 1):383-93.
1981: A Mauron; S Levy; Geoffrey Childs; Larry Kedes
Monocistronic transcription is the physiological mechanism of sea urchin embryonic histone gene expression.
Molecular and cellular biology 1981;1(7):661-71.
1981: Geoffrey Childs; Robert E Maxson; R H Cohn; Larry Kedes
Orphons: dispersed genetic elements derived from tandem repetitive genes of eucaryotes.
Cell 1981;23(3):651-63.
1979: Geoffrey Childs; R Maxson; L H Kedes
Histone gene expression during sea urchin embryogenesis: isolation and characterization of early and late messenger RNAs of Strongylocentrotus purpuratus by gene-specific hybridization and template activity.
Developmental biology 1979;73(1):153-73.
1979: Geoffrey Childs; S Levy; L H Kedes
Rapid purification of biologically active individual histone messenger RNAs by hybridization to cloned DNA linked to cellulose.
Biochemistry 1979;18(1):208-13.
1978: S Levy; Geoffrey Childs; L Kedes
Sea urchin nuclei use RNA polymerase II to transcribe discrete histone RNAs larger than messengers.
Cell 1978;15(1):151-62.
1977: Geoffrey Childs; H Ohtsubo; E Ohtsubo; F Sonnenberg; M Freundlich
Restriction endonuclease mapping of the Escherichia coli K12 chromosome in the vicinity of the ilv genes.
Journal of molecular biology 1977;117(1):175-93.
1977: Geoffrey Childs; F Sonnenberg; M Freundlich
Detection of messenger RNA from the isoleucine--valine operons of Salmonella typhimurium by heterologous DNA-RNA hybridization: involvement of transfer RNA in transcriptional repression.
Molecular & general genetics : MGG 1977;151(2):121-6.
1975: Geoffrey Childs; M Freundlich
Transcriptional control of the isoleucine-valine messenger RNA's in E. coli K-12.
Molecular & general genetics : MGG 1975;138(3):257-68.
1973: A Hirashima; Geoffrey Childs; M Inouye
Differential inhibitory effects of antibiotics on the biosynthesis of envelope proteins of Escherichia coli.
Journal of molecular biology 1973;79(2):373-89.