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Edwin Chilvers

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TOP 3
Nanak R P Singh; Judith Babar; Edwin R Chilvers; Andrew Johnson; A Michael Peters; Charlotte Summers
Acute lung injury results from failure of neutrophil de-priming: a new hypothesis.
Neda Farahi; Sarah Heard; Chrystalla Loutsios; A Michael Peters; Prina Ruparelia; Nanak R Singh; Chandra K Solanki; Kishor Solanki; Charlotte Summers; Kottekkattu K Balan; Alison M Condliffe; Edwin R Chilvers
Use of 111-Indium-labeled autologous eosinophils to establish the in vivo kinetics of human eosinophils in healthy subjects.
Andreas V Hadjinicolaou; Muhammad K Nisar; Edwin R Chilvers; Helen Parfrey; Andrew J K Ostör
Non-infectious pulmonary toxicity of rituximab: a systematic review.

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2012: Nanak R P Singh; Judith Babar; Edwin R Chilvers; Andrew Johnson; A Michael Peters; Charlotte Summers
Acute lung injury results from failure of neutrophil de-priming: a new hypothesis.
European journal of clinical investigation 2012;42(12):1342-9.
2012: Neda Farahi; Sarah Heard; Chrystalla Loutsios; A Michael Peters; Prina Ruparelia; Nanak R Singh; Chandra K Solanki; Kishor Solanki; Charlotte Summers; Kottekkattu K Balan; Alison M Condliffe; Edwin R Chilvers
Use of 111-Indium-labeled autologous eosinophils to establish the in vivo kinetics of human eosinophils in healthy subjects.
Blood 2012;120(19):4068-71.
2012: Andreas V Hadjinicolaou; Muhammad K Nisar; Edwin R Chilvers; Helen Parfrey; Andrew J K Ostör
Non-infectious pulmonary toxicity of rituximab: a systematic review.
Rheumatology (Oxford, England) 2012;51(4):653-62.
2012: Jatinder K Juss; Suhasini Kulkarni; Charles E Owen; Len Stephens; Sarah R Walmsley; Keith B Boyle; Ian Bruce; Edwin R Chilvers; Andrew S Cowburn; Phillip T Hawkins; Richard P Hayhoe; Alison M Condliffe
Functional redundancy of class I phosphoinositide 3-kinase (PI3K) isoforms in signaling growth factor-mediated human neutrophil survival.
PloS one 2012;7(9):e45933.
2012: Andrew E Ekpenyong; Christine Fiddler; Kevin Chalut; Edwin R Chilvers; Ulrich F Keyser; Franziska Lautenschläger; Stefano Pagliara; Stephan Paschke; Graeme Whyte; Jochen Guck
Viscoelastic properties of differentiating blood cells are fate- and function-dependent.
PloS one 2012;7(9):e45237.
2011: Andreas V Hadjinicolaou; Muhammad K Nisar; Shweta Bhagat; Edwin R Chilvers; Helen Parfrey; Andrew J K Ostör
Non-infectious pulmonary complications of newer biological agents for rheumatic diseases--a systematic literature review.
Rheumatology (Oxford, England) 2011;50(12):2297-305.
2011: Prina Ruparelia; Katherine R Szczepura; Charlotte Summers; Chandra K Solanki; Kottekkattu K Balan; Paul Newbold; Diana Bilton; A Michael Peters; Edwin R Chilvers
Quantification of neutrophil migration into the lungs of patients with chronic obstructive pulmonary disease.
European journal of nuclear medicine and molecular imaging 2011;38(5):911-9.
2011: Neda Farahi; L Uller; J K Juss; A J Langton; Andrew S Cowburn; A Gibson; M R Foster; S N Farrow; P Marco-Casanova; A Sobolewski; Alison M Condliffe; Edwin R Chilvers
Effects of the cyclin-dependent kinase inhibitor R-roscovitine on eosinophil survival and clearance.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2011;41(5):673-87.
2011: James A Irving; Sam Alam; Didier Belorgey; Edwin R Chilvers; Lucy E Dalton; Ugo I Ekeowa; Bibek Gooptu; Imran Haq; Ravi Mahadeva; Stefan Marciniak; Elena Miranda; Adriana Ordóñez; Helen Parfrey; Juan Pérez; S Tamir Rashid; Benoit D Roussel; Jeffrey H Teckman; Sally E Thomas; Ludovic Vallier; David A Lomas
The serpinopathies studying serpin polymerization in vivo.
Methods in enzymology 2011;501():421-66.
2011: Naomi N McGovern; Andrew S Cowburn; Linsey Porter; Sarah R Walmsley; Charlotte Summers; Alfred A R Thompson; Sadia Anwar; Lisa C Willcocks; Moira K B Whyte; Alison M Condliffe; Edwin R Chilvers
Hypoxia selectively inhibits respiratory burst activity and killing of Staphylococcus aureus in human neutrophils.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(1):453-63.
2011: Katherine R Szczepura; Prina Ruparelia; Chandra K Solanki; Kottekkattu Balan; Paul Newbold; Charlotte Summers; Edwin R Chilvers; A Michael Peters
Measuring whole-body neutrophil redistribution using a dedicated whole-body counter and ultra-low doses of 111Indium.
European journal of clinical investigation 2011;41(1):77-83.
2010: Sven Brode; Neda Farahi; Andrew S Cowburn; Jatinder K Juss; Alison M Condliffe; Edwin R Chilvers
Interleukin-5 inhibits glucocorticoid-mediated apoptosis in human eosinophils.
Thorax 2010;65(12):1116-7.
2010: Helen Parfrey; Neda Farahi; Linsey Porter; Edwin R Chilvers
Live and let die: is neutrophil apoptosis defective in severe asthma?
Thorax 2010;65(8):665-7.
2010: Charlotte Summers; Sara M Rankin; Alison M Condliffe; Nanak Singh; A Michael Peters; Edwin R Chilvers
Neutrophil kinetics in health and disease.
Trends in immunology 2010;31(8):318-24.
2010: Edwin R Chilvers; David A Lomas
Diagnosing COPD in non-smokers: splitting not lumping.
Thorax 2010;65(6):465-6.
2010: Damian McKeon; K A Cadwallader; S Idris; A S Cowburn; M C Pasteur; H Barker; Charles S Haworth; Diana Bilton; Edwin R Chilvers; A M Condliffe
Cystic fibrosis neutrophils have normal intrinsic reactive oxygen species generation.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2010;35(6):1264-72.
2010: Helen Parfrey; C A Fiddler; J Babar; Edwin R Chilvers
Idiopathic pulmonary fibrosis in a Christmas Island nuclear test veteran.
BMJ case reports 2010;2010():.
2009: Heok K Cheow; Prina Ruparelia; Sonal Shankar; Katherine R Szczepura; James R Ballinger; Neil G Hartman; Edwin R Chilvers; A Michael Peters
Does P-glycoprotein have a role in the lung clearances of inhaled 99mTc-sestamibi and 99mTc-tetrofosmin?
Nuclear medicine communications 2009;30(8):617-21.
2009: S Y Sundram-Novelend; D S Appleton; R J Davies; Nicholas J Screaton; Edwin R Chilvers
Spontaneous rupture of an intercostal artery aneurysm during air flight.
BMJ case reports 2009;2009():bcr2006074690.
2009: Sarah R Walmsley; Edwin R Chilvers; Moira K B Whyte
Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function.
Arthritis research & therapy 2009;11(2):219.
2008: Andrew S Cowburn; Alison M Condliffe; Neda Farahi; Charlotte Summers; Edwin R Chilvers
Advances in neutrophil biology: clinical implications.
Chest 2008;134(3):606-12.
2008: Lisa C Willcocks; Paul A Lyons; Menna R Clatworthy; James Robinson; Wanling Yang; Stephen A Newland; Vincent Plagnol; Naomi N McGovern; Alison M Condliffe; Edwin R Chilvers; Dwomoa Adu; Elaine C Jolly; Richard Watts; Yu Lung Lau; Ann W Morgan; Gerard Nash; Kenneth G C Smith
Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake.
The Journal of experimental medicine 2008;205(7):1573-82.
2008: Prina Ruparelia; Heok K Cheow; John W Evans; Leith Banney; Sonal Shankar; Katherine R Szczepura; Anna E Swift; James R Ballinger; Neil G Hartman; Edwin R Chilvers; A Michael Peters
Pulmonary elimination rate of inhaled 99mTc-sestamibi radioaerosol is delayed in healthy cigarette smokers.
British journal of clinical pharmacology 2008;65(4):611-4.
2008: S Y Sundram-Novelend; DS Appleton; Nicholas J Screaton; R J Davies; Edwin R Chilvers
Spontaneous rupture of an intercostal artery aneurysm during air flight.
Thorax 2008;63(3):294.
2008: Sarah R Walmsley; Naomi N McGovern; Moira K B Whyte; Edwin R Chilvers
The HIF/VHL pathway: from oxygen sensing to innate immunity.
American journal of respiratory cell and molecular biology 2008;38(3):251-5.
2007: Neda Farahi; Andrew S Cowburn; Paul D Upton; John Deighton; Anastasia Sobolewski; Ermanno Gherardi; Nicholas W Morrell; Edwin R Chilvers
Eotaxin-1/CC chemokine ligand 11: a novel eosinophil survival factor secreted by human pulmonary artery endothelial cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(2):1264-73.
2006: Sabine Suire; Alison M Condliffe; Gordon ferguson; Chris D Ellson; Hervé Guillou; Keith Davidson; Heidi Welch; John Coadwell; Martin Turner; Edwin R Chilvers; Phillip T Hawkins; Len Stephens
Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils.
Nature cell biology 2006;8(11):1303-9.
2006: Sarah R Walmsley; Andrew S Cowburn; Menna R Clatworthy; Nicholas W Morrell; Emma C Roper; Vanessa Singleton; Patrick Maxwell; Moira K B Whyte; Edwin R Chilvers
Neutrophils from patients with heterozygous germline mutations in the von Hippel Lindau protein (pVHL) display delayed apoptosis and enhanced bacterial phagocytosis.
Blood 2006;108(9):3176-8.
2006: Andrew S Cowburn; Anastasia Sobolewski; Benjamin J Reed; John Deighton; Joanna Murray; Karen A Cadwallader; John R Bradley; Edwin R Chilvers
Aminopeptidase N (CD13) regulates tumor necrosis factor-alpha-induced apoptosis in human neutrophils.
The Journal of biological chemistry 2006;281(18):12458-67.
2006: Alison M Condliffe; Louise M C Webb; Gordon ferguson; Keith Davidson; Martin Turner; Elena Vigorito; Maria Manifava; Edwin R Chilvers; Len R Stephens; Phillip T Hawkins
RhoG regulates the neutrophil NADPH oxidase.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(9):5314-20.
2006: Andrew J K Ostör; Edwin R Chilvers; Margaret F Somerville; Anita Y N Lim; Suzanne E Lane; Adrian J Crisp; D G I Scott
Pulmonary complications of infliximab therapy in patients with rheumatoid arthritis.
The Journal of rheumatology 2006;33(3):622-8.
2005: Trevor R Walker; Karen A Cadwallader; Alison MacKinnon; Edwin R Chilvers
Thrombin induces DNA synthesis and phosphoinositide hydrolysis in airway smooth muscle by activation of distinct receptors.
Biochemical pharmacology 2005;70(6):959-67.
2005: Alison M Condliffe; Keith Davidson; Karen E Anderson; Chris D Ellson; Tom Crabbe; Klaus Okkenhaug; Bart Vanhaesebroeck; Martin Turner; Louise Webb; Matthias P Wymann; Emilio Hirsch; Thomas Ruckle; Montserrat Camps; Christian Rommel; Shaun P Jackson; Edwin R Chilvers; Len R Stephens; Phillip T Hawkins
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils.
Blood 2005;106(4):1432-40.
2005: Sarah R Walmsley; Karen A Cadwallader; Edwin R Chilvers
The role of HIF-1alpha in myeloid cell inflammation.
Trends in immunology 2005;26(8):434-9.
2005: TJ Brazil; MP Dagleish; Bruce C McGorum; PM Dixon; Christopher Haslett; Edwin R Chilvers
Kinetics of pulmonary neutrophil recruitment and clearance in a natural and spontaneously resolving model of airway inflammation.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2005;35(7):854-65.
2005: Andrew S Cowburn; Jessica F White; John Deighton; Sarah R Walmsley; Edwin R Chilvers
z-VAD-fmk augmentation of TNF alpha-stimulated neutrophil apoptosis is compound specific and does not involve the generation of reactive oxygen species.
Blood 2005;105(7):2970-2.
2005: Heok K Cheow; Demetrius D Voutnis; John W Evans; Katy R Szczepura; E Anna Swift; Nicholas J Bird; Prina Ruparelia; Chandra K Solanki; James R Ballinger; Edwin R Chilvers; Stephen J Middleton; A Michael Peters
Quantification of disease activity in patients undergoing leucocyte scintigraphy for suspected inflammatory bowel disease.
European journal of nuclear medicine and molecular imaging 2005;32(3):329-37.
2005: Sarah R Walmsley; Cristin G Print; Neda Farahi; Carole Peyssonnaux; Randall S Johnson; Thorsten Cramer; Anastasia Sobolewski; Alison M Condliffe; Andrew S Cowburn; Nicola Johnson; Edwin R Chilvers
Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity.
The Journal of experimental medicine 2005;201(1):105-15.
2004: Neda Farahi; Andrew S Cowburn; A G Rossi; Edwin R Chilvers
Eating their way out of trouble: selective uptake of apoptotic eosinophils by bronchial epithelial cells.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2004;34(10):1503-6.
2004: Karen A Cadwallader; Mohib Uddin; Alison M Condliffe; Andrew S Cowburn; Jessica F White; Jeremy N Skepper; Nicholas T Ktistakis; Edwin R Chilvers
Effect of priming on activation and localization of phospholipase D-1 in human neutrophils.
European journal of biochemistry / FEBS 2004;271(13):2755-64.
2004: Gwenny M Fuhler; Karen A Cadwallader; Gerlinde J Knol; Edwin R Chilvers; A Lyndsay Drayer; Edo Vellenga
Disturbed granulocyte macrophage-colony stimulating factor priming of phosphatidylinositol 3,4,5-trisphosphate accumulation and Rac activation in fMLP-stimulated neutrophils from patients with myelodysplasia.
Journal of leukocyte biology 2004;76(1):254-62.
2004: Andrew S Cowburn; John Deighton; Sarah R Walmsley; Edwin R Chilvers
The survival effect of TNF-alpha in human neutrophils is mediated via NF-kappa B-dependent IL-8 release.
European journal of immunology 2004;34(6):1733-43.
2004: Ian Sabroe; Lynne R Prince; Steven K Dower; Sarah R Walmsley; Edwin R Chilvers; Moira K B Whyte
What can we learn from highly purified neutrophils?
Biochemical Society transactions 2004;32(Pt3):468-9.
2004: Sarah R Walmsley; Andrew S Cowburn; Anastasia Sobolewski; Joanna Murray; Neda Farahi; Ian Sabroe; Edwin R Chilvers
Characterization of the survival effect of tumour necrosis factor-alpha in human neutrophils.
Biochemical Society transactions 2004;32(Pt3):456-60.
2004: Hazel A Jones; T Donovan; Martin J Goddard; Keith McNeil; Carl Atkinson; John C Clark; Jessica F White; Edwin R Chilvers
Use of 18FDG-pet to discriminate between infection and rejection in lung transplant recipients.
Transplantation 2004;77(9):1462-4.
2004: A Michael Peters; Jessica F White; Edwin R Chilvers
Physiologic granulocyte destruction in vivo by apoptosis.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2004;45(3):526.
2004: Sarah R Walmsley; Karen K K Sheares; Anastasia Sobolewski; Nicholas W Morrell; Edwin R Chilvers
New insights into oxygen sensing at a cellular level.
Thorax 2004;59(2):90-2.
2003: Joanna Murray; Sarah R Walmsley; Katy I Mecklenburgh; Andrew S Cowburn; Jessica F White; A G Rossi; Edwin R Chilvers
Hypoxic regulation of neutrophil apoptosis role: of reactive oxygen intermediates in constitutive and tumor necrosis factor alpha-induced cell death.
Annals of the New York Academy of Sciences 2003;1010():417-25.
2003: Joanna Murray; Carol Ward; Joseph T O'Flaherty; Ian Dransfield; Christopher Haslett; Edwin R Chilvers; Adriano G Rossi
Role of leukotrienes in the regulation of human granulocyte behaviour: dissociation between agonist-induced activation and retardation of apoptosis.
British journal of pharmacology 2003;139(2):388-98.
2003: Stephen A Renshaw; Jasvir S Parmar; Vanessa Singleton; Sarah J Rowe; David H Dockrell; Steven K Dower; Colin D Bingle; Edwin R Chilvers; Moira K B Whyte
Acceleration of human neutrophil apoptosis by TRAIL.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(2):1027-33.
2003: Stephen J Skehan; Jessica F White; John W Evans; David R Parry-Jones; Chandra K Solanki; James R Ballinger; Edwin R Chilvers; A Michael Peters
Mechanism of accumulation of 99mTc-sulesomab in inflammation.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2003;44(1):11-8.
2002: Alison C Mackinnon; Avril Buckley; Edwin R Chilvers; Adriano G Rossi; Christopher Haslett; Tariq Sethi
Sphingosine kinase: a point of convergence in the action of diverse neutrophil priming agents.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(11):6394-400.
2002: Katy I Mecklenburgh; Sarah R Walmsley; Andrew S Cowburn; Michael S Wiesener; Benjamin J Reed; Paul D Upton; John Deighton; Andrew P Greening; Edwin R Chilvers
Involvement of a ferroprotein sensor in hypoxia-mediated inhibition of neutrophil apoptosis.
Blood 2002;100(8):3008-16.
2002: Andrew S Cowburn; Karen A Cadwallader; Benjamin J Reed; Neda Farahi; Edwin R Chilvers
Role of PI3-kinase-dependent Bad phosphorylation and altered transcription in cytokine-mediated neutrophil survival.
Blood 2002;100(7):2607-16.
2002: Karen A Cadwallader; Alison M Condliffe; Alex McGregor; Trevor R Walker; Jessica F White; Len R Stephens; Edwin R Chilvers
Regulation of phosphatidylinositol 3-kinase activity and phosphatidylinositol 3,4,5-trisphosphate accumulation by neutrophil priming agents.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(6):3336-44.
2002: Jasvir S Parmar; Ravi Mahadeva; Benjamin J Reed; Neda Farahi; Karen A Cadwallader; Mary T Keogan; Diana Bilton; Edwin R Chilvers; David A Lomas
Polymers of alpha(1)-antitrypsin are chemotactic for human neutrophils: a new paradigm for the pathogenesis of emphysema.
American journal of respiratory cell and molecular biology 2002;26(6):723-30.
2002: Hazel A Jones; Karen A Cadwallader; Jessica F White; Mohib Uddin; A Michael Peters; Edwin R Chilvers
Dissociation between respiratory burst activity and deoxyglucose uptake in human neutrophil granulocytes: implications for interpretation of (18)F-FDG PET images.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2002;43(5):652-7.
2002: Alan Pemberton; Tatyana S Zamolodchikova; Cheryl L Scudamore; Edwin R Chilvers; Hugh Miller; Trevor R Walker
Proteolytic action of duodenase is required to induce DNA synthesis in pulmonary artery fibroblasts.
European journal of biochemistry / FEBS 2002;269(4):1171-80.
2001: Chris D Ellson; Karen E Anderson; G Morgan; Edwin R Chilvers; Peter Lipp; Len R Stephens; Phillip T Hawkins
Phosphatidylinositol 3-phosphate is generated in phagosomal membranes.
Current biology : CB 2001;11(20):1631-5.
2001: Chris D Ellson; S Gobert-Gosse; Karen E Anderson; Keith Davidson; Hediye Erdjument-Bromage; Paul Tempst; Jan W Thuring; Matthew A Cooper; Ze-Yi Lim; Andrew B Holmes; PR Gaffney; John Coadwell; Edwin R Chilvers; Phillip T Hawkins; Len R Stephens
PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40(phox).
Nature cell biology 2001;3(7):679-82.
2000: Stuart J Hirst; Trevor R Walker; Edwin R Chilvers
Phenotypic diversity and molecular mechanisms of airway smooth muscle proliferation in asthma.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2000;16(1):159-77.
2000: C Ward; T H Wong; J Murray; Irfan Rahman; Christopher Haslett; Edwin R Chilvers; Adriano G Rossi
Induction of human neutrophil apoptosis by nitric oxide donors: evidence for a caspase-dependent, cyclic-GMP-independent, mechanism.
Biochemical pharmacology 2000;59(3):305-14.
2000: Alison M Condliffe; Karen A Cadwallader; Trevor R Walker; Robert C Rintoul; Andrew S Cowburn; Edwin R Chilvers
Phosphoinositide 3-kinase: a critical signalling event in pulmonary cells.
Respiratory research 2000;1(1):24-9.
2000: Edwin R Chilvers; Karen A Cadwallader; Benjamin J Reed; Jessica F White; Alison M Condliffe
The function and fate of neutrophils at the inflamed site: prospects for therapeutic intervention.
Journal of the Royal College of Physicians of London 2000;34(1):68-74.
1999: C Ward; Ian Dransfield; Edwin R Chilvers; C Haslett; A G Rossi
Pharmacological manipulation of granulocyte apoptosis: potential therapeutic targets.
Trends in pharmacological sciences 1999;20(12):503-9.
1999: Vera P Krymskaya; Raymond B Penn; MJ Orsini; P H Scott; Robin Plevin; Trevor R Walker; Andrew Eszterhas; Yassine Amrani; Edwin R Chilvers; Reynold A Panettieri
Phosphatidylinositol 3-kinase mediates mitogen-induced human airway smooth muscle cell proliferation.
The American journal of physiology 1999;277(1 Pt 1):L65-78.
1999: Andrew Paul; A Cuenda; Clare E Bryant; J Murray; Edwin R Chilvers; P Cohen; GW Gould; Robin Plevin
Involvement of mitogen-activated protein kinase homologues in the regulation of lipopolysaccharide-mediated induction of cyclo-oxygenase-2 but not nitric oxide synthase in RAW 264.7 macrophages.
Cellular signalling 1999;11(7):491-7.
1999: Tariq Sethi; Robert C Rintoul; SM Moore; Alison C Mackinnon; Donald Salter; C Choo; Edwin R Chilvers; Ian Dransfield; Seamas C Donnelly; R Strieter; Christopher Haslett
Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivo.
Nature medicine 1999;5(6):662-8.
1999: Carol Ward; Edwin R Chilvers; MF Lawson; James G Pryde; Satoko Fujihara; Stuart N Farrow; Christopher Haslett; Adriano G Rossi
NF-kappaB activation is a critical regulator of human granulocyte apoptosis in vitro.
The Journal of biological chemistry 1999;274(7):4309-18.
1998: Trevor R Walker; SM Moore; MF Lawson; Reynold A Panettieri; Edwin R Chilvers
Platelet-derived growth factor-BB and thrombin activate phosphoinositide 3-kinase and protein kinase B: role in mediating airway smooth muscle proliferation.
Molecular pharmacology 1998;54(6):1007-15.
1998: SM Moore; Robert C Rintoul; Trevor R Walker; Edwin R Chilvers; Christopher Haslett; Tariq Sethi
The presence of a constitutively active phosphoinositide 3-kinase in small cell lung cancer cells mediates anchorage-independent proliferation via a protein kinase B and p70s6k-dependent pathway.
Cancer research 1998;58(22):5239-47.
1998: Alison M Condliffe; Phillip T Hawkins; Len R Stephens; Christopher Haslett; Edwin R Chilvers
Priming of human neutrophil superoxide generation by tumour necrosis factor-alpha is signalled by enhanced phosphatidylinositol 3,4,5-trisphosphate but not inositol 1,4,5-trisphosphate accumulation.
FEBS letters 1998;439(1-2):147-51.
1998: Edwin R Chilvers; A G Rossi; J Murray; C Haslett
Regulation of granulocyte apoptosis and implications for anti-inflammatory therapy.
Thorax 1998;53(7):533-4.
1998: Alison M Condliffe; E Kitchen; Edwin R Chilvers
Neutrophil priming: pathophysiological consequences and underlying mechanisms.
Clinical science (London, England : 1979) 1998;94(5):461-71.
1998: Adriano G Rossi; J C McCutcheon; N Roy; Edwin R Chilvers; Christopher Haslett; Ian Dransfield
Regulation of macrophage phagocytosis of apoptotic cells by cAMP.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(7):3562-8.
1998: TJ Brazil; Adriano G Rossi; Christopher Haslett; Bruce C McGorum; PM Dixon; Edwin R Chilvers
Priming induces functional coupling of N-formyl-methionyl-leucyl-phenylalanine receptors in equine neutrophils.
Journal of leukocyte biology 1998;63(3):380-8.
1997: Joanna Murray; J A Barbara; S A Dunkley; A F Lopez; X Van Ostade; Alison M Condliffe; Ian Dransfield; Christopher Haslett; Edwin R Chilvers
Regulation of neutrophil apoptosis by tumor necrosis factor-alpha: requirement for TNFR55 and TNFR75 for induction of apoptosis in vitro.
Blood 1997;90(7):2772-83.
1997: Edwin R Chilvers; B J Lynch; R A Challiss
Dissociation between beta-adrenoceptor-mediated cyclic AMP accumulation and inhibition of histamine-stimulated phosphoinositide metabolism in airways smooth muscle.
Biochemical pharmacology 1997;53(10):1565-8.
1997: L K Dawson; C D Selby; K C Fearon; C J Mumford; Edwin R Chilvers
Abdominal pain associated with cranial nerve palsy and peripheral neuropathy.
Postgraduate medical journal 1997;73(859):305-6.
1997: Carol Ward; J Murray; L Bruce; S Farrow; Edwin R Chilvers; S Hannah; Christopher Haslett; Adriano G Rossi
Interleukin-10 does not directly affect the constitutive rate of human neutrophil or eosinophil apoptosis.
Biochemical Society transactions 1997;25(2):245S.
1997: Carol Ward; S Hannah; Edwin R Chilvers; S Farrow; Christopher Haslett; Adriano G Rossi
Transforming growth factor-beta increases the inhibitory effects of GM-CSF and dexamethasone on neutrophil apoptosis.
Biochemical Society transactions 1997;25(2):244S.
1997: Andrew Paul; C Bryant; MF Lawson; Edwin R Chilvers; Robin Plevin
Dissociation of lipopolysaccharide-mediated induction of nitric oxide synthase and inhibition of DNA synthesis in RAW 264.7 macrophages and rat aortic smooth muscle cells.
British journal of pharmacology 1997;120(8):1439-44.
1997: B J Lynch; M M Muqit; Trevor R Walker; Edwin R Chilvers
[3H]inositol polyphosphate metabolism in muscarinic cholinoceptor-stimulated airways smooth muscle: accumulation of [3H]inositol 4,5 bisphosphate via a lithium-sensitive inositol polyphosphate 1-phosphatase.
The Journal of pharmacology and experimental therapeutics 1997;280(2):974-82.
1996: E Kitchen; Adriano G Rossi; Alison M Condliffe; C Haslett; Edwin R Chilvers
Demonstration of reversible priming of human neutrophils using platelet-activating factor.
Blood 1996;88(11):4330-7.
1996: Pamela H Scott; CM Belham; J al-Hafidh; Edwin R Chilvers; Andrew J Peacock; G W Gould; Robin Plevin
A regulatory role for cAMP in phosphatidylinositol 3-kinase/p70 ribosomal S6 kinase-mediated DNA synthesis in platelet-derived-growth-factor-stimulated bovine airway smooth-muscle cells.
The Biochemical journal 1996;318 ( Pt 3)():965-71.
1996: A Tallett; Edwin R Chilvers; S Hannah; Ian Dransfield; M F Lawson; C Haslett; Tariq Sethi
Inhibition of neuropeptide-stimulated tyrosine phosphorylation and tyrosine kinase activity stimulates apoptosis in small cell lung cancer cells.
Cancer research 1996;56(18):4255-63.
1996: Alison M Condliffe; Edwin R Chilvers; C Haslett; Ian Dransfield
Priming differentially regulates neutrophil adhesion molecule expression/function.
Immunology 1996;89(1):105-11.
1996: E Kitchen; Alison M Condliffe; Adriano G Rossi; C Haslett; Edwin R Chilvers
Characterization of inositol hexakisphosphate (InsP6)-mediated priming in human neutrophils: lack of extracellular [3H]-InsP6 receptors.
British journal of pharmacology 1996;117(5):979-85.
1996: J Murray; Alison M Condliffe; C Haslett; Edwin R Chilvers
Wortmannin enhances tumour necrosis factor alpha-stimulated neutrophil apoptosis.
Biochemical Society transactions 1996;24(1):80S.
1996: A Tallett; Edwin R Chilvers; Alison C Mackinnon; C Haslett; Tariq Sethi
Neuropeptides stimulate tyrosine phosphorylation and tyrosine kinase activity in small cell lung cancer cell lines.
Peptides 1996;17(4):665-73.
1995: Adriano G Rossi; J M Cousin; Ian Dransfield; M F Lawson; Edwin R Chilvers; C Haslett
Agents that elevate cAMP inhibit human neutrophil apoptosis.
Biochemical and biophysical research communications 1995;217(3):892-9.
1995: K Malarkey; Edwin R Chilvers; M F Lawson; Robin Plevin
Stimulation by endothelin-1 of mitogen-activated protein kinases and DNA synthesis in bovine tracheal smooth muscle cells.
British journal of pharmacology 1995;116(4):2267-73.
1995: S Hannah; K Mecklenburgh; Irfan Rahman; G J Bellingan; A Greening; C Haslett; Edwin R Chilvers
Hypoxia prolongs neutrophil survival in vitro.
FEBS letters 1995;372(2-3):233-7.
1995: J Qu; Alison M Condliffe; M Lawson; R J Plevin; R A Riemersma; G R Barclay; D B McClelland; Edwin R Chilvers
Lack of effect of recombinant platelet-derived growth factor on human neutrophil function.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(8):4133-41.
1994: Edwin R Chilvers; M A Giembycz; R A John Challiss; G J Offer; Stefan R Nahorski
Effect of temperature on muscarinic cholinoceptor-mediated phosphoinositide metabolism and tension generation in bovine tracheal smooth muscle.
Naunyn-Schmiedeberg's archives of pharmacology 1994;350(6):585-91.
1994: Edwin R Chilvers; Tariq Sethi
How receptors work: mechanisms of signal transduction.
Postgraduate medical journal 1994;70(829):813-7.
1994: B J Lynch; J Challiss; Edwin R Chilvers
Characterisation and Ca(2+)-dependency of the soluble and particulate Ins(1,4,5)P3 5-phosphatase in bovine tracheal smooth muscle.
Biochemical Society transactions 1994;22(3):314S.
1994: Edwin R Chilvers; B J Lynch; G J Offer; R A John Challiss
Effects of membrane depolarization and changes in intra- and extracellular calcium concentration on phosphoinositide hydrolysis in bovine tracheal smooth muscle.
Biochemical pharmacology 1994;47(12):2171-9.
1994: Edwin R Chilvers; B J Lynch; R A John Challiss
Phosphoinositide metabolism in airway smooth muscle.
Pharmacology & therapeutics 1994;62(1-2):221-45.
1992: M K Whyte; A Michael Peters; J M Hughes; B L Henderson; G J Bellingan; James E Jackson; Edwin R Chilvers
Quantification of right to left shunt at rest and during exercise in patients with pulmonary arteriovenous malformations.
Thorax 1992;47(10):790-6.
1991: G J Offer; Edwin R Chilvers; Stefan R Nahorski
Beta-adrenoceptor induced inhibition of muscarinic receptor-stimulated phosphoinositide metabolism is agonist specific in bovine tracheal smooth muscle.
European journal of pharmacology 1991;207(3):243-8.
1991: Edwin R Chilvers; M A Giembycz; R A John Challiss; B J Barnes; Stefan R Nahorski
Lack of effect of zaprinast on methacholine-induced contraction and inositol 1,4,5-trisphosphate accumulation in bovine tracheal smooth muscle.
British journal of pharmacology 1991;103(1):1119-25.
1991: Edwin R Chilvers; I H Batty; R A John Challiss; Peter J Barnes; Stefan R Nahorski
Determination of mass changes in phosphatidylinositol 4,5-bisphosphate and evidence for agonist-stimulated metabolism of inositol 1,4,5-trisphosphate in airway smooth muscle.
The Biochemical journal 1991;275 ( Pt 2)():373-9.
1991: Edwin R Chilvers; R A John Challiss; Stefan R Nahorski
Detection of sustained mass increases in inositol 1,3,4,5-tetrakisphosphate in agonist-stimulated airway smooth muscle.
Biochemical Society transactions 1991;19(2):76S.
1990: Edwin R Chilvers; M K Whyte; James E Jackson; D J Allison; J M Hughes
Effect of percutaneous transcatheter embolization on pulmonary function, right-to-left shunt, and arterial oxygenation in patients with pulmonary arteriovenous malformations.
The American review of respiratory disease 1990;142(2):420-5.
1990: Edwin R Chilvers; Stefan R Nahorski
Phosphoinositide metabolism in airway smooth muscle.
The American review of respiratory disease 1990;141(3 Pt 2):S137-40.
1990: Edwin R Chilvers; I H Batty; Peter J Barnes; Stefan R Nahorski
Formation of inositol polyphosphates in airway smooth muscle after muscarinic receptor stimulation.
The Journal of pharmacology and experimental therapeutics 1990;252(2):786-91.
1990: Edwin R Chilvers; R A John Challiss; A L Willcocks; B V Potter; Peter J Barnes; Stefan R Nahorski
Characterisation of stereospecific binding sites for inositol 1,4,5-trisphosphate in airway smooth muscle.
British journal of pharmacology 1990;99(2):297-302.
1990: R A John Challiss; Edwin R Chilvers; A L Willcocks; Stefan R Nahorski
Heterogeneity of [3H]inositol 1,4,5-trisphosphate binding sites in adrenal-cortical membranes. Characterization and validation of a radioreceptor assay.
The Biochemical journal 1990;265(2):421-7.
1989: Edwin R Chilvers; R A John Challiss; Peter J Barnes; Stefan R Nahorski
Characterization of stereospecific binding sites for [3H]-inositol (1,4,5)-trisphosphate in airway smooth muscle.
British journal of pharmacology 1989;98 Suppl():787P.
1989: Edwin R Chilvers; H Garratt; M K Whyte; R Fink; P W Ind
Absence of circulating products of oxygen derived free radicals in acute severe asthma.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1989;2(10):950-4.
1989: Edwin R Chilvers; Peter J Barnes; Stefan R Nahorski
Characterization of agonist-stimulated incorporation of myo-[3H]inositol into inositol phospholipids and [3H]inositol phosphate formation in tracheal smooth muscle.
The Biochemical journal 1989;262(3):739-46.
1989: Edwin R Chilvers; R A John Challiss; Peter J Barnes; Stefan R Nahorski
Mass changes of inositol(1,4,5)trisphosphate in trachealis muscle following agonist stimulation.
European journal of pharmacology 1989;164(3):587-90.
1989: E D Kennedy; I H Batty; Edwin R Chilvers; Stefan R Nahorski
A simple enzymic method to separate [3H]inositol 1,4,5- and 1,3,4-trisphosphate isomers in tissue extracts.
The Biochemical journal 1989;260(1):283-6.
1989: J G Baird; Edwin R Chilvers; E D Kennedy; Stefan R Nahorski
Changes in extracellular calcium within the physiological range influence receptor-mediated inositol phosphate responses in brain and tracheal smooth muscle slices.
Naunyn-Schmiedeberg's archives of pharmacology 1989;339(3):247-51.
1988: Edwin R Chilvers; A Michael Peters; P George; J M Hughes; D J Allison
Quantification of right to left shunt through pulmonary arteriovenous malformations using 99Tcm albumin microspheres.
Clinical radiology 1988;39(6):611-4.
1988: Edwin R Chilvers; C M Dixon; Y Yiangou; Stephen R Bloom; P W Ind
Effect of peptide histidine valine on cardiovascular and respiratory function in normal subjects.
Thorax 1988;43(10):750-5.