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Alba Chimirri

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Laura De Luca; Francesca Morreale; Alba Chimirri
Insight into the fundamental interactions between LEDGF binding site inhibitors and integrase combining docking and molecular dynamics simulations.
Rosaria Gitto; Emilio Russo; Maria R Buemi; Mariangela Chisari; Lucia Ciranna; Laura De Luca; Giovambattista De Sarro; Stefania Ferro; Alba Chimirri
Synthesis and biological characterization of 3-substituted 1H-indoles as ligands of GluN2B-containing N-methyl-D-aspartate receptors. Part 2.
Emilio Russo; Rosaria Gitto; Alba Chimirri; Rita Citraro; Giovambattista De Sarro
New AMPA antagonists in epilepsy.

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All Publications

2012: Laura De Luca; Francesca Morreale; Alba Chimirri
Insight into the fundamental interactions between LEDGF binding site inhibitors and integrase combining docking and molecular dynamics simulations.
Journal of chemical information and modeling 2012;52(12):3245-54.
2012: Rosaria Gitto; Emilio Russo; Maria R Buemi; Mariangela Chisari; Lucia Ciranna; Laura De Luca; Giovambattista De Sarro; Stefania Ferro; Alba Chimirri
Synthesis and biological characterization of 3-substituted 1H-indoles as ligands of GluN2B-containing N-methyl-D-aspartate receptors. Part 2.
Journal of medicinal chemistry 2012;55(23):10532-9.
2012: Emilio Russo; Rosaria Gitto; Alba Chimirri; Rita Citraro; Giovambattista De Sarro
New AMPA antagonists in epilepsy.
Expert opinion on investigational drugs 2012;21(9):1371-89.
2012: Rosaria Gitto; Pavel Mader; Pavlína Rezáčová; Claudiu T Supuran; Daniela Vullo; Jirí Brynda; Francesca M Damiano; Laura De Luca; Stefania Ferro; Alba Chimirri
Synthesis, structure-activity relationship studies, and X-ray crystallographic analysis of arylsulfonamides as potent carbonic anhydrase inhibitors.
Journal of medicinal chemistry 2012;55(8):3891-9.
2012: Rosaria Gitto; Sara De Grazia; Laura De Luca; Alba Chimirri
Glutamatergic neurotransmission as molecular target of new anticonvulsants.
Current topics in medicinal chemistry 2012;12(9):971-93.
2011: Rosaria Gitto; Claudiu T Supuran; Daniela Vullo; Francesca Maria Damiano; Laura De Luca; Stefania Ferro; Alba Chimirri
Synthesis and biological profile of new 1,2,3,4-tetrahydroisoquinolines as selective carbonic anhydrase inhibitors.
Bioorganic & medicinal chemistry 2011;19(23):7003-7.
2011: Laura De Luca; zeger debyser; Stefania Ferro; Rosaria Gitto; Francesca Morreale; Frauke Christ; Sara De Grazia; Alba Chimirri
4-[1-(4-Fluorobenzyl)-4-hydroxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid as a prototype to develop dual inhibitors of HIV-1 integration process.
Antiviral research 2011;92(1):102-7.
2011: Laura De Luca; Stefania Ferro; Francesca Morreale; Sara De Grazia; Alba Chimirri
Inhibitors of the interactions between HIV-1 IN and the cofactor LEDGF/p75.
ChemMedChem 2011;6(7):1184-91.
2011: Pavel Mader; Jirí Brynda; Rosaria Gitto; Stefano Agnello; Petr Pachl; Claudiu T Supuran; Alba Chimirri; Pavlína Řezáčová
Structural basis for the interaction between carbonic anhydrase and 1,2,3,4-tetrahydroisoquinolin-2-ylsulfonamides.
Journal of medicinal chemistry 2011;54(7):2522-6.
2011: Laura De Luca; Sara De Grazia; Stefania Ferro; Rosaria Gitto; Frauke Christ; zeger debyser; Alba Chimirri
HIV-1 integrase strand-transfer inhibitors: design, synthesis and molecular modeling investigation.
European journal of medicinal chemistry 2011;46(2):756-64.
2011: Muriel Billamboz; Fabrice Bailly; Cédric Lion; Christina Calmels; Marie-Line Andréola; Myriam Witvrouw; Frauke Christ; zeger debyser; Laura De Luca; Alba Chimirri; Philippe Cotelle
2-hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: influence of the alkylation of position 4.
European journal of medicinal chemistry 2011;46(2):535-46.
2011: Stefania Ferro; Rosaria Gitto; Sara De Grazia; Laura De Luca; Zeger Debyzer; Caterina Elisa Faliti; Alba Chimirri
Microwave assisted organic synthesis (MAOS) of small molecules as potential HIV-1 integrase inhibitors.
Molecules (Basel, Switzerland) 2011;16(8):6858-70.
2010: Rosaria Gitto; Laura De Luca; Stefania Ferro; Stefano Agnello; Emilio Russo; Giovanbattista De Sarro; Alba Chimirri
Synthesis and structure-active relationship of 1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline anticonvulsants.
Chemical & pharmaceutical bulletin 2010;58(12):1602-5.
2010: Laura De Luca; Stefania Ferro; Rosaria Gitto; Maria Letizia Barreca; Stefano Agnello; Frauke Christ; zeger debyser; Alba Chimirri
Small molecules targeting the interaction between HIV-1 integrase and LEDGF/p75 cofactor.
Bioorganic & medicinal chemistry 2010;18(21):7515-21.
2010: Stefania Ferro; Laura De Luca; Maria Letizia Barreca; Sara De Grazia; Frauke Christ; zeger debyser; Alba Chimirri
New chloro,fluorobenzylindole derivatives as integrase strand-transfer inhibitors (INSTIs) and their mode of action.
Bioorganic & medicinal chemistry 2010;18(15):5510-8.
2010: Rosaria Gitto; Stefano Agnello; Stefania Ferro; Daniela Vullo; Claudiu T Supuran; Alba Chimirri
Identification of potent and selective human carbonic anhydrase VII (hCA VII) inhibitors.
ChemMedChem 2010;5(6):823-6.
2010: Alberta Samuele; Emmanuele Crespan; Samanta Vitellaro; Anna-Maria Monforte; Patrizia Logoteta; Alba Chimirri; giovanni maga
Slow binding-tight binding interaction between benzimidazol-2-one inhibitors and HIV-1 reverse transcriptase containing the lysine 103 to asparagine mutation.
Antiviral research 2010;86(3):268-75.
2010: Rosaria Gitto; Stefano Agnello; Stefania Ferro; Laura De Luca; Daniela Vullo; Jiri Brynda; Pavel Mader; Claudiu T Supuran; Alba Chimirri
Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as potent carbonic anhydrase inhibitors: synthesis, biological evaluation, and enzyme--ligand X-ray studies.
Journal of medicinal chemistry 2010;53(6):2401-8.
2010: Anna Maria Monforte; Patrizia Logoteta; Laura De Luca; Nunzio Iraci; Stefania Ferro; giovanni maga; Erik De Clercq; Christophe Pannecouque; Alba Chimirri
Novel 1,3-dihydro-benzimidazol-2-ones and their analogues as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry 2010;18(4):1702-10.
2009: Maria Letizia Barreca; Nunzio Iraci; Laura De Luca; Alba Chimirri
Induced-fit docking approach provides insight into the binding mode and mechanism of action of HIV-1 integrase inhibitors.
ChemMedChem 2009;4(9):1446-56.
2009: Anna Maria Monforte; Patrizia Logoteta; Stefania Ferro; Laura De Luca; Nunzio Iraci; giovanni maga; Erik De Clercq; Christophe Pannecouque; Alba Chimirri
Design, synthesis, and structure-activity relationships of 1,3-dihydrobenzimidazol-2-one analogues as anti-HIV agents.
Bioorganic & medicinal chemistry 2009;17(16):5962-7.
2009: Laura De Luca; Maria Letizia Barreca; Stefania Ferro; Frauke Christ; Nunzio Iraci; Rosaria Gitto; Anna Maria Monforte; zeger debyser; Alba Chimirri
Pharmacophore-based discovery of small-molecule inhibitors of protein-protein interactions between HIV-1 integrase and cellular cofactor LEDGF/p75.
ChemMedChem 2009;4(8):1311-6.
2009: Alba Chimirri; Laura De Luca; Stefania Ferro; Giovanbattista De Sarro; Lucia Ciranna; Rosaria Gitto
Combined strategies for the discovery of ionotropic glutamate receptor antagonists.
ChemMedChem 2009;4(6):917-22.
2009: Rosaria Gitto; Stefania Ferro; Stefano Agnello; Laura De Luca; Giovanbattista De Sarro; Emilio Russo; Daniela Vullo; Claudiu T Supuran; Alba Chimirri
Synthesis and evaluation of pharmacological profile of 1-aryl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamides.
Bioorganic & medicinal chemistry 2009;17(10):3659-64.
2009: Rosaria Gitto; Benedetta Pagano; Rita Citraro; Francesca Scicchitano; Giovanbattista De Sarro; Alba Chimirri
Solution-phase parallel synthesis and evaluation of anticonvulsant activity of N-substituted-3,4-dihydroisoquinoline-2(1H)-carboxamides.
European journal of medicinal chemistry 2009;44(3):1349-54.
2009: Rosaria Gitto; Laura De Luca; Stefania Ferro; Rita Citraro; Giovambattista De Sarro; Lara Costa; Lucia Ciranna; Alba Chimirri
Development of 3-substituted-1H-indole derivatives as NR2B/NMDA receptor antagonists.
Bioorganic & medicinal chemistry 2009;17(4):1640-7.
2009: Stefania Ferro; Laura De Luca; Maria Letizia Barreca; Nunzio Iraci; Sara De Grazia; Frauke Christ; Myriam Witvrouw; zeger debyser; Alba Chimirri
Docking studies on a new human immunodeficiency virus integrase-Mg-DNA complex: phenyl ring exploration and synthesis of 1H-benzylindole derivatives through fluorine substitutions.
Journal of medicinal chemistry 2009;52(2):569-73.
2008: Rosaria Gitto; Laura De Luca; Stefania Ferro; Francesco Occhiuto; Stefania Samperi; Giovambattista De Sarro; Emilio Russo; Lucia Ciranna; Lara Costa; Alba Chimirri
Computational studies to discover a new NR2B/NMDA receptor antagonist and evaluation of pharmacological profile.
ChemMedChem 2008;3(10):1539-48.
2008: Anna Maria Monforte; Angela Rao; Patrizia Logoteta; Stefania Ferro; Laura De Luca; Maria Letizia Barreca; Nunzio Iraci; giovanni maga; Erik De Clercq; Christophe Pannecouque; Alba Chimirri
Novel N1-substituted 1,3-dihydro-2H-benzimidazol-2-ones as potent non-nucleoside reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry 2008;16(15):7429-35.
2008: Anneleen Hombrouck; Barbara Van Remoortel; Martine Michiels; Wim Noppe; Frauke Christ; Anders Eneroth; Britt Louise Sahlberg; Kurt Benkestock; Lotta Vrang; Nils Gunnar Johansson; Maria Letizia Barreca; Laura De Luca; Stefania Ferro; Alba Chimirri; zeger debyser; Myriam Witvrouw
Preclinical evaluation of 1H-benzylindole derivatives as novel human immunodeficiency virus integrase strand transfer inhibitors.
Antimicrobial agents and chemotherapy 2008;52(8):2861-9.
2008: Emilio Russo; Rita Citraro; Salvatore De Fazio; Rosario Marra; Rosaria Gitto; Alba Chimirri; Giovambattista De Sarro; Eugenio Donato Di Paola
Enhancement of anti-absence effects of ethosuximide by low doses of a noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist in a genetic animal model of absence epilepsy.
Epilepsy & behavior : E&B 2008;13(2):295-9.
2008: Laura De Luca; Maria Letizia Barreca; Stefania Ferro; Nunzio Iraci; Martine Michiels; Frauke Christ; zeger debyser; Myriam Witvrouw; Alba Chimirri
A refined pharmacophore model for HIV-1 integrase inhibitors: Optimization of potency in the 1H-benzylindole series.
Bioorganic & medicinal chemistry letters 2008;18(9):2891-5.
2008: Armando M De Palma; Ward Heggermont; Kjerstin Lanke; Bruno Coutard; Mirko Bergmann; Anna-Maria Monforte; Bruno Canard; Erik De Clercq; Alba Chimirri; Gerhard Pürstinger; Jacques Rohayem; Frank van Kuppeveld; Johan Neyts
The thiazolobenzimidazole TBZE-029 inhibits enterovirus replication by targeting a short region immediately downstream from motif C in the nonstructural protein 2C.
Journal of virology 2008;82(10):4720-30.
2008: Rosaria Gitto; Laura De Luca; Benedetta Pagano; Rita Citraro; Giovambattista De Sarro; Lara Costa; Lucia Ciranna; Alba Chimirri
Synthesis and anticonvulsant evaluation of N-substituted isoquinoline AMPA receptor antagonists.
Bioorganic & medicinal chemistry 2008;16(5):2379-84.
2008: Rosaria Gitto; Eleonora Francica; Giovambattista De Sarro; Francesca Scicchitano; Alba Chimirri
Solution-phase parallel synthesis of novel 1,2,3,4-tetrahydroisoquinoline-1-ones as anticonvulsant agents.
Chemical & pharmaceutical bulletin 2008;56(2):181-4.
2007: Maria Letizia Barreca; Francesco Ortuso; Nunzio Iraci; Laura De Luca; Stefano Alcaro; Alba Chimirri
Tn5 transposase as a useful platform to simulate HIV-1 integrase inhibitor binding mode.
Biochemical and biophysical research communications 2007;363(3):554-60.
2007: Rosaria Gitto; Rita Ficarra; Rosanna Stancanelli; Marta Guardo; Laura De Luca; Maria Letizia Barreca; Benedetta Pagano; Archimede Rotondo; Giuseppe Bruno; Emilio Russo; Giovambattista De Sarro; Alba Chimirri
Synthesis, resolution, stereochemistry, and molecular modeling of (R)- and (S)-2-acetyl-1-(4'-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline AMPAR antagonists.
Bioorganic & medicinal chemistry 2007;15(16):5417-23.
2007: Stefania Ferro; Maria Letizia Barreca; Laura De Luca; Angela Rao; Anna Maria Monforte; zeger debyser; Myriam Witvrouw; Alba Chimirri
New 4-[(1-benzyl-1H-indol-3-yl)carbonyl]-3-hydroxyfuran-2(5H)-ones, beta-diketo acid analogs as HIV-1 integrase inhibitors.
Archiv der Pharmazie 2007;340(6):292-8.
2007: M Rizzo; D Ventrice; F Casale; G De Sarro; Rosaria Gitto; Alba Chimirri
Determination of a potent non-competitive AMPA receptor antagonist in rat brain.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;850(1-2):161-7.
2007: Maria Letizia Barreca; Angela Rao; Laura De Luca; Nunzio Iraci; Anna Maria Monforte; giovanni maga; Erik De Clercq; Christophe Pannecouque; Jan Balzarini; Alba Chimirri
Discovery of novel benzimidazolones as potent non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains.
Bioorganic & medicinal chemistry letters 2007;17(7):1956-60.
2007: Maria Letizia Barreca; Laura De Luca; Nunzio Iraci; Angela Rao; Stefania Ferro; giovanni maga; Alba Chimirri
Structure-based pharmacophore identification of new chemical scaffolds as non-nucleoside reverse transcriptase inhibitors.
Journal of chemical information and modeling 2007;47(2):557-62.
2007: Armando De Palma; Ward Heggermont; Pieter Leyssen; Gerhard Pürstinger; Eva Wimmer; Erik De Clercq; Angela Rao; Anna-Maria Monforte; Alba Chimirri; Johan Neyts
Anti-enterovirus activity and structure-activity relationship of a series of 2,6-dihalophenyl-substituted 1H,3H-thiazolo[3,4-a]benzimidazoles.
Biochemical and biophysical research communications 2007;353(3):628-32.
2007: Andrea Savarino; Mauro Pistello; Daniela D'Ostilio; Elisa Zabogli; Fabiana Taglia; Fabiola Mancini; Stefania Ferro; Donatella Matteucci; Laura De Luca; Maria Letizia Barreca; Alessandra Ciervo; Alba Chimirri; Massimo Ciccozzi; Mauro Bendinelli
Human immunodeficiency virus integrase inhibitors efficiently suppress feline immunodeficiency virus replication in vitro and provide a rationale to redesign antiretroviral treatment for feline AIDS.
Retrovirology 2007;4():79.
2006: P Donato; Rosanna Stancanelli; Maria Luisa Calabrò; Silvana Tommasini; P Cutroneo; Marta Guardo; Benedetta Pagano; Alba Chimirri; Paola Ficarra; Rita Ficarra
Optimization of a LC method for the enantioseparation of a non-competitive glutamate receptor antagonist, by experimental design methodology.
Journal of pharmaceutical and biomedical analysis 2006;42(5):543-8.
2006: Rita Citraro; Emilio Russo; Santo Gratteri; Eugenio Donato Di Paola; Guido Ferreri Ibbadu; Carmela Curinga; Rosaria Gitto; Alba Chimirri; Giuseppe Donato; Giovambattista De Sarro
Effects of non-competitive AMPA receptor antagonists injected into some brain areas of WAG/Rij rats, an animal model of generalized absence epilepsy.
Neuropharmacology 2006;51(6):1058-67.
2006: Rosaria Gitto; Roberta Caruso; Benedetta Pagano; Laura De Luca; Rita Citraro; Emilio Russo; Giovambattista De Sarro; Alba Chimirri
Novel potent anticonvulsant agent containing a tetrahydroisoquinoline skeleton.
Journal of medicinal chemistry 2006;49(18):5618-22.
2006: Erik Arstad; Rosaria Gitto; Alba Chimirri; Roberta Caruso; Andrew Constanti; David Turton; Susan P Hume; Rabia Ahmad; Lyn S Pilowsky; Sajinder K Luthra
Closing in on the AMPA receptor: synthesis and evaluation of 2-acetyl-1-(4'-chlorophenyl)-6-methoxy-7-[11C]methoxy-1,2,3,4-tetrahydroisoquinoline as a potential PET tracer.
Bioorganic & medicinal chemistry 2006;14(14):4712-7.
2006: Laura De Luca; Rosaria Gitto; Maria Letizia Barreca; Roberta Caruso; Silvana Quartarone; Rita Citraro; Giovambattista De Sarro; Alba Chimirri
3D pharmacophore models for 1,2,3,4-tetrahydroisoquinoline derivatives acting as anticonvulsant agents.
Archiv der Pharmazie 2006;339(7):388-400.
2006: Maria Letizia Barreca; Laura De Luca; Nunzio Iraci; Alba Chimirri
Binding mode prediction of strand transfer HIV-1 integrase inhibitors using Tn5 transposase as a plausible surrogate model for HIV-1 integrase.
Journal of medicinal chemistry 2006;49(13):3994-7.
2005: Laura De Luca; Giulio Vistoli; Alessandro Pedretti; Maria Letizia Barreca; Alba Chimirri
Molecular dynamics studies of the full-length integrase-DNA complex.
Biochemical and biophysical research communications 2005;336(4):1010-6.
2005: Maria Letizia Barreca; Stefania Ferro; Angela Rao; Laura De Luca; Maria Zappalà; Anna Maria Monforte; zeger debyser; Myriam Witvrouw; Alba Chimirri
Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors.
Journal of medicinal chemistry 2005;48(22):7084-8.
2005: M Rizzo; D Ventrice; G De Sarro; Rosaria Gitto; R Caruso; Alba Chimirri
SPE-HPLC determination of new tetrahydroisoquinoline derivatives in rat plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;821(1):15-21.
2005: Maria Letizia Barreca; Angela Rao; Laura De Luca; Maria Zappalà; Anna Maria Monforte; giovanni maga; Christophe Pannecouque; Jan Balzarini; Erik De Clercq; Alba Chimirri; Pietro Monforte
Computational strategies in discovering novel non-nucleoside inhibitors of HIV-1 RT.
Journal of medicinal chemistry 2005;48(9):3433-7.
2005: Giovambattista De Sarro; Rosaria Gitto; Emilio Russo; Guido Ferreri Ibbadu; Maria Letizia Barreca; Laura De Luca; Alba Chimirri
AMPA receptor antagonists as potential anticonvulsant drugs.
Current topics in medicinal chemistry 2005;5(1):31-42.
2004: A Rao; Jan Balzarini; A Carbone; Alba Chimirri; Erik De Clercq; Anna Maria Monforte; Pietro Monforte; Christophe Pannecouque; Maria Zappalà
2-(2,6-Dihalophenyl)-3-(pyrimidin-2-yl)-1,3-thiazolidin-4-ones as non-nucleoside HIV-1 reverse transcriptase inhibitors.
Antiviral research 2004;63(2):79-84.
2004: Maria Letizia Barreca; Angela Rao; Laura De Luca; Maria Zappalà; Cristina Gurnari; Pietro Monforte; Erik De Clercq; Bénédicte Van Maele; zeger debyser; Myriam Witvrouw; James M Briggs; Alba Chimirri
Efficient 3D database screening for novel HIV-1 IN inhibitors.
Journal of chemical information and computer sciences 2004;44(4):1450-5.
2004: Silvana Quartarone; Roberta Caruso; Valérie Orlando; Emilio Russo; Giovambattista De Sarro; Alba Chimirri
Synthesis and anticonvulsant activity of N-3 substituted 2,3-benzodiazepines.
Farmaco (Società chimica italiana : 1989) 2004;59(5):353-8.
2004: Antonio Macchiarulo; Laura De Luca; Gabriele Costantino; Maria Letizia Barreca; Rosaria Gitto; Roberto Pellicciari; Alba Chimirri
QSAR study of anticonvulsant negative allosteric modulators of the AMPA receptor.
Journal of medicinal chemistry 2004;47(7):1860-3.
2004: Angela Rao; Jan Balzarini; Anna Carbone; Alba Chimirri; Erik De Clercq; Anna Maria Monforte; Pietro Monforte; Christophe Pannecouque; Maria Zappalà
Synthesis of new 2,3-diaryl-1,3-thiazolidin-4-ones as anti-HIV agents.
Farmaco (Società chimica italiana : 1989) 2004;59(1):33-9.
2004: Rosaria Gitto; Roberta Caruso; Valérie Orlando; Silvana Quartarone; Maria Letizia Barreca; Guido Ferreri; Emilio Russo; Giovambattista De Sarro; Alba Chimirri
Synthesis and anticonvulsant properties of tetrahydroisoquinoline derivatives.
Farmaco (Società chimica italiana : 1989) 2004;59(1):7-12.
2004: Guido Ferreri; Alba Chimirri; Emilio Russo; Rosaria Gitto; Pietro Gareri; Angela De Sarro; Giovambattista De Sarro
Comparative anticonvulsant activity of N-acetyl-1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives in rodents.
Pharmacology, biochemistry, and behavior 2004;77(1):85-94.
2003: Laura De Luca; Alessandro Pedretti; Giulio Vistoli; Maria Letizia Barreca; Luigi Villa; Pietro Monforte; Alba Chimirri
Analysis of the full-length integrase-DNA complex by a modified approach for DNA docking.
Biochemical and biophysical research communications 2003;310(4):1083-8.
2003: Rosaria Gitto; Valérie Orlando; Silvana Quartarone; Giovambattista De Sarro; Angela De Sarro; Emilio Russo; Guido Ferreri; Alba Chimirri
Synthesis and evaluation of pharmacological properties of novel annelated 2,3-benzodiazepine derivatives.
Journal of medicinal chemistry 2003;46(17):3758-61.
2003: Maria Letizia Barreca; Rosaria Gitto; Silvana Quartarone; Laura De Luca; Giovambattista De Sarro; Alba Chimirri
Pharmacophore modeling as an efficient tool in the discovery of novel noncompetitive AMPA receptor antagonists.
Journal of chemical information and computer sciences 2003;43(2):651-5.
2003: Maria Letizia Barreca; Alba Chimirri; Erik De Clercq; Laura De Luca; Anna Maria Monforte; Pietro Monforte; Angela Rao; Maria Zappalà
Anti-HIV agents: design and discovery of new potent RT inhibitors.
Farmaco (Società chimica italiana : 1989) 2003;58(3):259-63.
2003: Maria Letizia Barreca; Keun Woo Lee; Alba Chimirri; James M Briggs
Molecular dynamics studies of the wild-type and double mutant HIV-1 integrase complexed with the 5CITEP inhibitor: mechanism for inhibition and drug resistance.
Biophysical journal 2003;84(3):1450-63.
2003: Angela Rao; Anna Carbone; Alba Chimirri; Erik De Clercq; Anna Maria Monforte; Pietro Monforte; Christophe Pannecouque; Maria Zappalà
Synthesis and anti-HIV activity of 2,3-diaryl-1,3-thiazolidin-4-ones.
Farmaco (Società chimica italiana : 1989) 2003;58(2):115-20.
2003: Laura De Luca; Antonio Macchiarulo; Gabriele Costantino; Maria Letizia Barreca; Rosaria Gitto; Alba Chimirri; Roberto Pellicciari
Binding modes of noncompetitive AMPA antagonists: a computational approach.
Farmaco (Società chimica italiana : 1989) 2003;58(2):107-13.
2003: Giovambattista De Sarro; Guido Ferreri; Pietro Gareri; Emilio Russo; Angela De Sarro; Rosaria Gitto; Alba Chimirri
Comparative anticonvulsant activity of some 2,3-benzodiazepine derivatives in rodents.
Pharmacology, biochemistry, and behavior 2003;74(3):595-602.
2003: Rosaria Gitto; Maria Letizia Barreca; Laura De Luca; Giovambattista De Sarro; Guido Ferreri; Silvana Quartarone; Emilio Russo; Andrew Constanti; Alba Chimirri
Discovery of a novel and highly potent noncompetitive AMPA receptor antagonist.
Journal of medicinal chemistry 2003;46(1):197-200.
2002: Maria Letizia Barreca; Jan Balzarini; Alba Chimirri; Erik De Clercq; Laura De Luca; Hans-Dieter Höltje; Monika Höltje; Anna Maria Monforte; Pietro Monforte; Christophe Pannecouque; Angela Rao; Maria Zappalà
Design, synthesis, structure-activity relationships, and molecular modeling studies of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV agents.
Journal of medicinal chemistry 2002;45(24):5410-3.
2002: Angela Rao; Alba Chimirri; Erik De Clercq; Anna Maria Monforte; Pietro Monforte; Christophe Pannecouque; Maria Zappalà
Synthesis and anti-hIV activity of 1-(2,6-difluorophenyl)-1H,3H-thiazolo[3,4-a]benzimidazole structurally-related 1,2-substituted benzimidazoles.
Farmaco (Società chimica italiana : 1989) 2002;57(10):819-23.
2002: Giovambattista De Sarro; Alba Chimirri; Brian S Meldrum
Group III mGlu receptor agonists potentiate the anticonvulsant effect of AMPA and NMDA receptor block.
European journal of pharmacology 2002;451(1):55-61.
2002: Alba Chimirri; Rosaria Gitto; Silvana Quartarone; Valérie Orlando; Angela De Sarro; Giovambattista De Sarro
Synthesis and pharmacological properties of new 3-ethoxycarbonyl-11H-[1,2,4]triazolo[4,5-c][2,3]benzodiazepines.
Farmaco (Società chimica italiana : 1989) 2002;57(9):759-63.
2002: Angela Rao; Anna Carbone; Alba Chimirri; Erik De Clercq; Anna Maria Monforte; Pietro Monforte; Christophe Pannecouque; Maria Zappalà
Synthesis and anti-HIV activity of 2,3-diaryl-1,3-thiazolidin-4-(thi)one derivatives.
Farmaco (Società chimica italiana : 1989) 2002;57(9):747-51.
2002: Rosaria Gitto; Maria Zappal; Sarro Giovambattista De; Alba Chimirri
Design and development of 2,3-benzodiazepine (CFM) noncompetitive AMPA receptor antagonists.
Farmaco (Società chimica italiana : 1989) 2002;57(2):129-34.
2001: Alba Chimirri; Angela De Sarro; Giovambattista De Sarro; Rosaria Gitto; Maria Zappalà
Synthesis and anticonvulsant properties of 2,3,3a,4-tetrahydro-1H-pyrrolo[1,2-a]benzimidazol-1-one derivatives.
Farmaco (Società chimica italiana : 1989) 2001;56(11):821-6.
2001: Maria Letizia Barreca; Alba Chimirri; Laura De Luca; Anna Maria Monforte; Pietro Monforte; Angela Rao; Maria Zappalà; Jan Balzarini; Erik De Clercq; Christophe Pannecouque; Myriam Witvrouw
Discovery of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV-1 agents.
Bioorganic & medicinal chemistry letters 2001;11(13):1793-6.
2001: Alba Chimirri; Pietro Monforte; L Musumeci; Angela Rao; Maria Zappalà; Anna Maria Monforte
Synthesis and antitumour activity of 1H,3H-thiazolo[3,4-a]benzimidazole derivatives.
Archiv der Pharmazie 2001;334(6):203-8.
2001: Alba Chimirri; Pietro Monforte; Angela Rao; Maria Zappalà; Anna Maria Monforte; G De Sarro; Christophe Pannecouque; Myriam Witvrouw; Jan Balzarini; Erik De Clercq
Synthesis, biological activity, pharmacokinetic properties and molecular modelling studies of novel 1H,3H-oxazolo[3,4-a]benzimidazoles: non-nucleoside HIV-1 reverse transcriptase inhibitors.
Antiviral chemistry & chemotherapy 2001;12(3):169-74.
2000: Maria Zappalà; Rosaria Gitto; F Bevacqua; Silvana Quartarone; Alba Chimirri; M Rizzo; Giovambattista De Sarro; Angela De Sarro
Synthesis and evaluation of pharmacological and pharmacokinetic properties of 11H-[1,2,4]triazolo[4,5-c][2,3]benzodiazepin-3(2H)-ones.
Journal of medicinal chemistry 2000;43(25):4834-9.
1999: Maria Letizia Barreca; Angelo Carotti; Antonio Carrieri; Alba Chimirri; Anna Maria Monforte; M P Calace; Angela Rao
Comparative molecular field analysis (CoMFA) and docking studies of non-nucleoside HIV-1 RT inhibitors (NNIs).
Bioorganic & medicinal chemistry 1999;7(11):2283-92.
1999: M Rizzo; G De Sarro; Maria Zappalà; Alba Chimirri
Determination of new 2,3-benzodiazepines in rat plasma using high-performance liquid chromatography with ultraviolet detection.
Journal of chromatography. B, Biomedical sciences and applications 1999;731(2):207-15.
1999: Giovambattista De Sarro; M Rizzo; C Spagnolo; Rosaria Gitto; Angela De Sarro; G Scotto; M Zappala; Alba Chimirri
Anticonvulsant activity and plasma level of 2,3-benzodiazepin-4-ones (CFMs) in genetically epilepsy-prone rats.
Pharmacology, biochemistry, and behavior 1999;63(4):621-7.
1999: Alba Chimirri; Silvana Grasso; Pietro Monforte; Angela Rao; Maria Zappalà; Anna Maria Monforte; Christophe Pannecouque; Myriam Witvrouw; Jan Balzarini; Erik De Clercq
Synthesis and biological activity of novel 1H,3H-thiazolo[3,4-a]benzimidazoles: non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors.
Antiviral chemistry & chemotherapy 1999;10(4):211-7.
1999: M Rizzo; G De Sarro; Rosaria Gitto; Maria Zappalà; Alba Chimirri
Determination of 2,3-benzodiazepine derivatives in rat plasma by high-performance liquid chromatography.
Journal of chromatography. A 1999;846(1-2):165-8.
1998: Giovambattista De Sarro; M Rizzo; VA Sinopoli; Rosaria Gitto; Angela De Sarro; M Zappala; Alba Chimirri
Relationship between anticonvulsant activity and plasma level of some 2,3-benzodiazepines in genetically epilepsy-prone rats.
Pharmacology, biochemistry, and behavior 1998;61(3):215-20.
1998: Alba Chimirri; Silvana Grasso; Anna Maria Monforte; Pietro Monforte; Angela Rao; Maria Zappalà; G Bruno; F Nicolò; Christophe Pannecouque; Myriam Witvrouw; Erik De Clercq
Synthesis, structure and in vitro anti-human immunodeficiency virus activity of novel 3-methyl-1H,3H-thiazolo[3,4-a]benzimidazoles.
Antiviral chemistry & chemotherapy 1998;9(5):431-8.
1998: Alba Chimirri; Giovambattista De Sarro; Angela De Sarro; Rosaria Gitto; Silvana Quartarone; Maria Zappalà; Andrew Constanti; V Libri
3,5-Dihydro-4H-2,3-benzodiazepine-4-thiones: a new class of AMPA receptor antagonists.
Journal of medicinal chemistry 1998;41(18):3409-16.
1998: M Rizzo; VA Sinopoli; Rosaria Gitto; Maria Zappalà; Giovambattista De Sarro; Alba Chimirri
High-performance liquid chromatographic determination of new 2,3-benzodiazepines.
Journal of chromatography. B, Biomedical sciences and applications 1998;705(1):149-53.
1997: Alba Chimirri; Silvana Grasso; Anna Maria Monforte; Pietro Monforte; Angela Rao; Maria Zappalà; G Bruno; F Nicolò; R Scopelliti
Anti-HIV agents. V. Synthesis, structure and in vitro anti-HIV activity of novel 1H,3H-naphtho[2',3':4,5]imidazo[1,2-c]thiazoles.
Farmaco (Società chimica italiana : 1989) 1997;52(11):673-7.
1997: Giovambattista De Sarro; Alba Chimirri; Ruth M McKernan; Kathleen Quirk; P Giusti; Angela De Sarro
Anticonvulsant activity of azirino[1,2-d][1,4]benzodiazepines and related 1,4-benzodiazepines in mice.
Pharmacology, biochemistry, and behavior 1997;58(1):281-9.
1997: Alba Chimirri; Giovambattista De Sarro; Angela De Sarro; Rosaria Gitto; Silvana Grasso; Silvana Quartarone; Maria Zappalà; P Giusti; V Libri; Andrew Constanti; A G Chapman
1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: novel AMPA receptor antagonists.
Journal of medicinal chemistry 1997;40(8):1258-69.
1996: Giovambattista De Sarro; Alba Chimirri; M Zappala; P Guisti; M Lipartiti; Angela De Sarro
Azirino[1, 2-d][1, 4]benzodiazepine derivatives and related 1,4-benzodiazepines as anticonvulsant agents in DBA/2 mice.
General pharmacology 1996;27(7):1155-62.
1996: Alba Chimirri; Silvana Grasso; C Molica; Anna Maria Monforte; Pietro Monforte; Maria Zappalà; R Scopelliti
Anti-HIV agents. IV. Synthesis and in vitro anti-HIV activity of novel 1-(2,6-difluorophenyl)-1H,3H-thiazolo[3,4-a]benzimidazoles.
Farmaco (Società chimica italiana : 1989) 1996;51(4):279-82.
1996: Alba Chimirri; Silvana Grasso; Anna Maria Monforte; Angela Rao; M Zappala
Synthesis and antitumor activity evaluation of Delta2-1,2,4-oxadiazoline derivatives.
Farmaco (Società chimica italiana : 1989) 1996;51(2):125-9.
1996: Cosimo Altomare; Saverio Cellamare; Angelo Carotti; M L Barreca; Alba Chimirri; Anna Maria Monforte; Francesco Gasparrini; Claudio Villani; M Cirilli; F Mazza
Substituent effects on the enantioselective retention of anti-HIV 5-aryl-delta 2-1,2,4-oxadiazolines on R,R-DACH-DNB chiral stationary phase.
Chirality 1996;8(8):556-66.
1995: Giovambattista De Sarro; Alba Chimirri; Angela De Sarro; Rosaria Gitto; Silvana Grasso; P Giusti; A G Chapman
GYKI 52466 and related 2,3-benzodiazepines as anticonvulsant agents in DBA/2 mice.
European journal of pharmacology 1995;294(2-3):411-22.
1995: Alba Chimirri; Silvana Grasso; Anna Maria Monforte; Pietro Monforte; Maria Zappalà
Novel pyrrolo- and thiazolo-imidazoles.
Farmaco (Società chimica italiana : 1989) 1995;50(6):401-4.
1994: Alba Chimirri; Rosaria Gitto; Silvana Grasso; Anna Maria Monforte; Maria Zappalà
Synthesis and antitumor activity evaluation of 1-[(arylidene)amino]adamantanes.
Farmaco (Società chimica italiana : 1989) 1994;49(10):649-51.
1994: Angela De Sarro; Giovambattista De Sarro; Alba Chimirri; Silvana Grasso; Anna Maria Monforte; Maria Zappalà
Anticonvulsant activity of pyrrolo[1',2':1,2]imidazo[4,5-b]pyridines, pyrrolo[2',1':2,3]imidazo[4,5-c] pyridines and pyrrolo[2,1-f]purines in DBA/2 mice.
General pharmacology 1994;25(5):1027-31.
1994: Alba Chimirri; Silvana Grasso; Anna Maria Monforte; Pietro Monforte; Maria Zappalà; Angelo Carotti
Synthesis and in vitro anti-HIV activity of novel delta 2-1,2,4-oxadiazoline derivatives.
Farmaco (Società chimica italiana : 1989) 1994;49(7-8):509-11.
1994: Alba Chimirri; Silvana Grasso; A M Montforte; Pietro Monforte; Maria Zappalà
Anti-HIV agents. III. Synthesis and in vitro anti-HIV activity of novel 1H,3H-thiazolo[3,4-a]imidazo[4,5-b]pyridines.
Farmaco (Società chimica italiana : 1989) 1994;49(5):345-8.
1994: Alba Chimirri; Silvana Grasso; A M Montforte; P Montforte; Maria Zappalà; Angelo Carotti
Structure-activity relationships of antitumor thiazolo[3,4-a]benzimidazole derivatives.
Farmaco (Società chimica italiana : 1989) 1994;49(5):337-44.
1994: Alba Chimirri; Rosaria Gitto; Silvana Grasso; Maria Zappalà; Angela De Sarro; G Battista De Sarro
Structure-activity relationships in thienodiazepine and benzodiazepine derivatives.
Farmaco (Società chimica italiana : 1989) 1994;49(3):193-6.
1993: Alba Chimirri; Silvana Grasso; Pietro Monforte; Maria Zappalà; G Genchi
Pyrrolo[1',2':1,2]imidazo[4,5-b]pyridines, pyrrolo- [2',1':2,3]imidazo[4,5-c]pyridines and pyrrolo[2,1-f]purines as potential benzodiazepine ligands.
Farmaco (Società chimica italiana : 1989) 1993;48(9):1261-9.
1993: Angela De Sarro; M Zappalá; Alba Chimirri; Silvana Grasso; G B De Sarro
Quinolones potentiate cefazolin-induced seizures in DBA/2 mice.
Antimicrobial agents and chemotherapy 1993;37(7):1497-503.
1993: G B DeSarro; Maria Zappalà; S Grasso; Alba Chimirri; A DeSarro
Molecular requirement for anticonvulsant activity in a series of thiazolo-1,4-benzodiazepine derivatives and comparison with classical benzodiazepines.
General pharmacology 1993;24(4):877-84.
1991: Alba Chimirri; Silvana Grasso; Anna Maria Monforte; M Zappala; Angela De Sarro; G B De Sarro
Synthesis and anticonvulsant properties of 3-(1,3,4-thiadiazol-2-yl) thiazolidin-4-ones.
Farmaco (Società chimica italiana : 1989) 1991;46(7-8):935-43.
1991: Alba Chimirri; Silvana Grasso; Anna Maria Monforte; Pietro Monforte; M Zappala
Anti-HIV agents II. Synthesis and in vitro anti-HIV activity of novel 1H,3H-thiazolo[3,4-a]benzimidazoles.
Farmaco (Società chimica italiana : 1989) 1991;46(7-8):925-33.
1991: Alba Chimirri; Silvana Grasso; Anna Maria Monforte; Pietro Monforte; Maria Zappalà
Anti-HIV agents. I: Synthesis and in vitro anti-HIV evaluation of novel 1H,3H-thiazolo[3,4-a]benzimidazoles.
Farmaco (Società chimica italiana : 1989) 1991;46(6):817-23.
1991: Alba Chimirri
Novel annelated 1,4- and 1,5-benzodiazepines.
Farmaco (Società chimica italiana : 1989) 1991;46(1 Suppl):289-95.
1989: Alba Chimirri; Angela De Sarro; Giovambattista De Sarro; Silvana Grasso; Giuseppe Trimarchi; Maria Zappalà
Synthesis and anticonvulsant properties of 2,3,3a,4-tetrahydro-1H-pyrrolo[1,2-a]benzimidazol-1-ones.
Journal of medicinal chemistry 1989;32(1):93-5.
1988: Silvana Grasso; Alba Chimirri; Pietro Monforte; G Fenech; Maria Zappalà; Anna Maria Monforte
Compounds with potential antitumor activity. VI--2-Alkyl-3-[2-(1,3,4-thiadiazolyl)]-4-thiazolidinones.
Il Farmaco; edizione scientifica 1988;43(10):851-6.
1988: Silvana Grasso; Alba Chimirri; Pietro Monforte; G Fenech; Maria Zappalà; Anna Maria Monforte
Compounds with potential antitumor activity--note VIII: 1-alkyl-N,N'-di (1,3,4-thiadiazol-2-yl)methylenediamines.
Bollettino chimico farmaceutico 1988;127(7-8):198-201.
1986: Alba Chimirri; Silvana Grasso; Pietro Monforte; G Fenech; Maria Zappalà
[Compounds with potential antitumor activity. V. 2-Substituted 3-[2-(1,3,4-thiadazolyl)]-4-thiazolidinone].
Il Farmaco; edizione scientifica 1986;41(11):839-51.
1986: Silvana Grasso; Alba Chimirri; Pietro Monforte; G Fenech; Maria Zappalà
[Compounds with potential antitumor activity. IV. Synthesis and antileukemic activity of 1-aryl-N,N'-di-[2-(1,3,4-thiadiazolyl)]methylenediamine].
Il Farmaco; edizione scientifica 1986;41(9):713-21.
1984: Alba Chimirri; Silvana Grasso; G Fenech; Pietro Monforte; C Circosta; F Occhiuto; S Ragusa
1-Halophenyl-N,N'-di-(2-heteroaryl)-methylendiamines and 1-halophenyl-3-(2-heteroaryl)-thiazolidin-4-ones as potential hypotensive agents.
Bollettino chimico farmaceutico 1984;123(9):416-24.
1984: Alba Chimirri; Silvana Grasso; Pietro Monforte; G Fenech
[Compounds with presumable antitumor activity. III. 1-Substituted N,N'-di-2-pyrimidinyl (or pyrazinyl)methylenediamine].
Il Farmaco; edizione scientifica 1984;39(9):797-805.
1984: Silvana Grasso; Alba Chimirri; Pietro Monforte; G Fenech
[Compounds with presumable antitumor activity. II. 2-Substituted 3-(2-thiazolyl) and 3-[2-(1,3,4,-thiadizolyl)]-4-thiazolidinones].
Il Farmaco; edizione scientifica 1984;39(6):505-13.
1981: Pietro Monforte; Silvana Grasso; Alba Chimirri; G Fenech
[2-Substituted thiazole derivatives with possible antitumor activity].
Il Farmaco; edizione scientifica 1981;36(2):109-15.