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Alexander Aleshin

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Sergey A Shiryaev; Alexander Sloutsky; Alexander E Aleshin; Piotr Cieplak; Khatereh Motamedchaboki; Qing Sun; Wenhong Zhu; Alex Y Strongin
Matrix metalloproteinase proteolysis of the mycobacterial HSP65 protein as a potential source of immunogenic peptides in human tuberculosis.
Sergey A Shiryaev; Andrei V Chernov; Tatiana N Shiryaeva; Alexander E Aleshin; Alex Y Strongin
The acidic sequence of the NS4A cofactor regulates ATP hydrolysis by the HCV NS3 helicase.
Vladislav S Golubkov; Alexei V Chekanov; Piotr Cieplak; Alexander E Aleshin; Andrei V Chernov; Wenhong Zhu; Ilian A Radichev; Danhua Zhang; P Duc Dong; Alex Y Strongin
The Wnt/planar cell polarity protein-tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase: implications in cancer and embryogenesis.

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All Publications

2011: Sergey A Shiryaev; Alexander Sloutsky; Alexander E Aleshin; Piotr Cieplak; Khatereh Motamedchaboki; Qing Sun; Wenhong Zhu; Alex Y Strongin
Matrix metalloproteinase proteolysis of the mycobacterial HSP65 protein as a potential source of immunogenic peptides in human tuberculosis.
The FEBS journal 2011;278(18):3277-86.
2011: Sergey A Shiryaev; Andrei V Chernov; Tatiana N Shiryaeva; Alexander E Aleshin; Alex Y Strongin
The acidic sequence of the NS4A cofactor regulates ATP hydrolysis by the HCV NS3 helicase.
Archives of virology 2011;156(2):313-8.
2010: Vladislav S Golubkov; Alexei V Chekanov; Piotr Cieplak; Alexander E Aleshin; Andrei V Chernov; Wenhong Zhu; Ilian A Radichev; Danhua Zhang; P Duc Dong; Alex Y Strongin
The Wnt/planar cell polarity protein-tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase: implications in cancer and embryogenesis.
The Journal of biological chemistry 2010;285(46):35740-9.
2010: Vladislav Golubkov; Piotr Cieplak; Alexei V Chekanov; Boris I Ratnikov; Alexander E Aleshin; Natalya V Golubkova; Tatiana I Postnova; Ilian A Radichev; Dmitri V Rozanov; Wenhong Zhu; Khatereh Motamedchaboki; Alex Y Strongin
Internal cleavages of the autoinhibitory prodomain are required for membrane type 1 matrix metalloproteinase activation, although furin cleavage alone generates inactive proteinase.
The Journal of biological chemistry 2010;285(36):27726-36.
2010: Sergey A Shiryaev; Ilian A Radichev; Boris I Ratnikov; Alexander E Aleshin; Katarzyna Gawlik; Boguslaw Stec; Christian Frisch; Achim Knappik; Alex Y Strongin
Isolation and characterization of selective and potent human Fab inhibitors directed to the active-site region of the two-component NS2B-NS3 proteinase of West Nile virus.
The Biochemical journal 2010;427(3):369-76.
2009: Alexander E Aleshin; Svetlana Gramatikova; Gregory L Hura; Andrey Bobkov; Alex Y Strongin; Boguslaw Stec; John A Tainer; Robert C Liddington; Jeffrey W Smith
Crystal and solution structures of a prokaryotic M16B peptidase: an open and shut case.
Structure (London, England : 1993) 2009;17(11):1465-75.
2009: Sergey A Shiryaev; Andrei V Chernov; Alexander E Aleshin; Tatiana N Shiryaeva; Alex Y Strongin
NS4A regulates the ATPase activity of the NS3 helicase: a novel cofactor role of the non-structural protein NS4A from West Nile virus.
The Journal of general virology 2009;90(Pt 9):2081-5.
2008: Andrei V Chernov; Sergey A Shiryaev; Alexander E Aleshin; Boris I Ratnikov; Jeffrey W Smith; Robert C Liddington; Alex Y Strongin
The two-component NS2B-NS3 proteinase represses DNA unwinding activity of the West Nile virus NS3 helicase.
The Journal of biological chemistry 2008;283(25):17270-8.
2003: Alexander E Aleshin; Ping-Hua Feng; Richard B Honzatko; Peter J Reilly
Crystal structure and evolution of a prokaryotic glucoamylase.
Journal of molecular biology 2003;327(1):61-73.
2000: Alexander E Aleshin; C Kirby; X Liu; Gleb P Bourenkov; Hans D Bartunik; Herbert J Fromm; Richard B Honzatko
Crystal structures of mutant monomeric hexokinase I reveal multiple ADP binding sites and conformational changes relevant to allosteric regulation.
Journal of molecular biology 2000;296(4):1001-15.
1999: Alexander E Aleshin; M Malfois; X Liu; Chang Sup Kim; Herbert J Fromm; Richard B Honzatko; Michel H J Koch; Dmitri I Svergun
Nonaggregating mutant of recombinant human hexokinase I exhibits wild-type kinetics and rod-like conformations in solution.
Biochemistry 1999;38(26):8359-66.
1998: Alexander E Aleshin; C Zeng; Hans D Bartunik; Herbert J Fromm; Richard B Honzatko
Regulation of hexokinase I: crystal structure of recombinant human brain hexokinase complexed with glucose and phosphate.
Journal of molecular biology 1998;282(2):345-57.
1998: Alexander E Aleshin; Herbert J Fromm; Richard B Honzatko
Multiple crystal forms of hexokinase I: new insights regarding conformational dynamics, subunit interactions, and membrane association.
FEBS letters 1998;434(1-2):42-6.
1998: Tsuei-Yun Fang; O Alechina; Alexander E Aleshin; Herbert J Fromm; Richard B Honzatko
Identification of a phosphate regulatory site and a low affinity binding site for glucose 6-phosphate in the N-terminal half of human brain hexokinase.
The Journal of biological chemistry 1998;273(31):19548-53.
1998: Alexander E Aleshin; C Zeng; Gleb P Bourenkov; Hans D Bartunik; Herbert J Fromm; Richard B Honzatko
The mechanism of regulation of hexokinase: new insights from the crystal structure of recombinant human brain hexokinase complexed with glucose and glucose-6-phosphate.
Structure (London, England : 1993) 1998;6(1):39-50.
1998: C Zeng; Alexander E Aleshin; G Chen; Richard B Honzatko; Herbert J Fromm
The roles of glycine residues in the ATP binding site of human brain hexokinase.
The Journal of biological chemistry 1998;273(2):700-4.
1996: L F Shyur; Alexander E Aleshin; Richard B Honzatko; Herbert J Fromm
Biochemical properties of mutant and wild-type fructose-1,6-bisphosphatases are consistent with the coupling of intra- and intersubunit conformational changes in the T- and R-state transition.
The Journal of biological chemistry 1996;271(52):33301-7.
1996: C Zeng; Alexander E Aleshin; J B Hardie; Robert W Harrison; Herbert J Fromm
ATP-binding site of human brain hexokinase as studied by molecular modeling and site-directed mutagenesis.
Biochemistry 1996;35(40):13157-64.
1996: Alexander E Aleshin; C Zeng; Herbert J Fromm; Richard B Honzatko
Crystallization and preliminary X-ray analysis of human brain hexokinase.
FEBS letters 1996;391(1-2):9-10.
1996: Alexander E Aleshin; B Stoffer; L M Firsov; Birte Svensson; Richard B Honzatko
Crystallographic complexes of glucoamylase with maltooligosaccharide analogs: relationship of stereochemical distortions at the nonreducing end to the catalytic mechanism.
Biochemistry 1996;35(25):8319-28.
1996: L F Shyur; Alexander E Aleshin; Herbert J Fromm
A study of subunit interface residues of fructose-1,6-bisphosphatase by site-directed mutagenesis: effects on AMP and Mg2+ affinities.
Biochemistry 1996;35(23):7492-8.
1996: L F Shyur; Alexander E Aleshin; Richard B Honzatko; Herbert J Fromm
Site-directed mutagenesis of residues at subunit interfaces of porcine fructose-1,6-bisphosphatase.
The Journal of biological chemistry 1996;271(6):3005-10.
1995: B Stoffer; Alexander E Aleshin; L M Firsov; Birte Svensson; Richard B Honzatko
Refined structure for the complex of D-gluco-dihydroacarbose with glucoamylase from Aspergillus awamori var. X100 to 2.2 A resolution: dual conformations for extended inhibitors bound to the active site of glucoamylase.
FEBS letters 1995;358(1):57-61.
1994: L M Firsov; Kirill N Neustroev; Alexander E Aleshin; C M Metzler; D E Metzler; R D Scott; B Stoffer; Trine Christensen; Birte Svensson
NMR spectroscopy of exchangeable protons of glucoamylase and of complexes with inhibitors in the 9-15-ppm range.
European journal of biochemistry / FEBS 1994;223(1):293-302.
1994: Alexander E Aleshin; L M Firsov; Richard B Honzatko
Refined structure for the complex of acarbose with glucoamylase from Aspergillus awamori var. X100 to 2.4-A resolution.
The Journal of biological chemistry 1994;269(22):15631-9.
1994: Alexander E Aleshin; C Hoffman; L M Firsov; Richard B Honzatko
Refined crystal structures of glucoamylase from Aspergillus awamori var. X100.
Journal of molecular biology 1994;238(4):575-91.
1993: E M Harris; Alexander E Aleshin; L M Firsov; Richard B Honzatko
Refined structure for the complex of 1-deoxynojirimycin with glucoamylase from Aspergillus awamori var. X100 to 2.4-A resolution.
Biochemistry 1993;32(6):1618-26.
1992: Alexander E Aleshin; Alexander M Golubev; L M Firsov; Richard B Honzatko
Crystal structure of glucoamylase from Aspergillus awamori var. X100 to 2.2-A resolution.
The Journal of biological chemistry 1992;267(27):19291-8.
1992: Alexander M Golubev; Kirill N Neustroev; Alexander E Aleshin; L M Firsov
Crystallization and preliminary X-ray study of minor glucoamylase from Aspergillus awamori variant X-100/D27.
Journal of molecular biology 1992;226(1):271-2.