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Lynda Chin

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TOP 3
Lixing Yang; Chengsheng Zhang; Alexei Protopopov; Xiaojia Ren; Ruibin Xi; Lynda Chin; Nils Gehlenborg; Psalm S Haseley; Chih-Heng Hsieh; Raju Kucherlapati; Charles Lee; Lovelace J Luquette; Peter J Park
Diverse mechanisms of somatic structural variations in human cancer genomes.
Lynda Chin; Frederic de Sauvage; Mikala Egeblad; Kenneth P Olive; David Tuveson; William Weiss
Recapitulating human cancer in a mouse.
Nils Gehlenborg; Gad Getz; Michael S Noble; Lynda Chin; Peter J Park
Nozzle: a report generation toolkit for data analysis pipelines.

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All Publications

2013: Lixing Yang; Chengsheng Zhang; Alexei Protopopov; Xiaojia Ren; Ruibin Xi; Lynda Chin; Nils Gehlenborg; Psalm S Haseley; Chih-Heng Hsieh; Raju Kucherlapati; Charles Lee; Lovelace J Luquette; Peter J Park
Diverse mechanisms of somatic structural variations in human cancer genomes.
Cell 2013;153(4):919-29.
2013: Lynda Chin; Frederic de Sauvage; Mikala Egeblad; Kenneth P Olive; David Tuveson; William Weiss
Recapitulating human cancer in a mouse.
Nature biotechnology 2013;31(5):392-5.
2013: Nils Gehlenborg; Gad Getz; Michael S Noble; Lynda Chin; Peter J Park
Nozzle: a report generation toolkit for data analysis pipelines.
Bioinformatics (Oxford, England) 2013;29(8):1089-91.
2012: Steven N Quayle; Sachet A Shukla; Pablo Tamayo; Ruprecht Wiedemeyer; Yonghong Xiao; Li Zhuang; Robert W Dewan; William C Hahn; Sam Haidar; Emmet Huang-Hobbs; Keith L Ligon; Milan G Chheda; Lynda Chin
Integrative functional genomics identifies RINT1 as a novel GBM oncogene.
Neuro-oncology 2012;14(11):1325-31.
2012: Tatianna C Larman; Alexei Protopopov; Christine E Seidman; Lynda Chin; Steven R Depalma; Stacey B Gabriel; Angela G Hadjipanayis; Raju Kucherlapati; Jianhua Zhang; Jonathan G Seidman
Spectrum of somatic mitochondrial mutations in five cancers.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(35):14087-91.
2012: Giannicola Genovese; Papia Ghosh; Jason Hanna; Lawrence N Kwong; Steven N Quayle; Kunal Rai; David L Rimm; Sharmistha Sarkar; Sachet A Shukla; Wolf Ruprecht Wiedemeyer; Chang-Jiun Wu; Yonghong Xiao; Haoqiang Ying; Hailei Zhang; Jianhua Zhang; Hongwu Zheng; Simona Colla; James J Collins; Katherine Dunn; Ayla Ergun; Cameron Brennan; Benito Campos; Lynda Chin
microRNA regulatory network inference identifies miR-34a as a novel regulator of TGF-β signaling in glioblastoma.
Cancer discovery 2012;2(8):736-49.
2012: Hensin Tsao; Levi A Garraway; Lynda Chin; David E Fisher
Melanoma: from mutations to medicine.
Genes & development 2012;26(11):1131-55.
2012: Zhihu Ding; Boyi Gan; James W Horner; Jian Hu; Elena Ivanova; Mariela Jaskelioff; Shan Jiang; Maria Kost-Alimova; Emma S Labrot; Liren Li; Xin Lu; Samuel R Perry; Alexei Protopopov; Guocan Wang; Wei Wang; Y Alan Wang; Chang-Jiun Wu; Yonghong Xiao; Hailei Zhang; Jianhua Zhang; Jingfang Zhang; Lynda Chin; Gerald Chu; Ronald A DePinho
Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases.
Cell 2012;148(5):896-907.
2012: Jian Hu; Soyoon Sarah Hwang; Elena Ivanova; Mariela Jaskelioff; Shawn Johnson; Maria Kost-Alimova; Marc Liesa; Alexei Protopopov; Ergun Sahin; Orian S Shirihai; Yaoqi Alan Wang; Haoqiang Ying; Hailei Zhang; Adam T Boutin; Lynda Chin; Zhihu Ding; Boyi Gan; Ronald A DePinho
Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer.
Cell 2012;148(4):651-63.
2012: Steven N Quayle; Ruprecht Wiedemeyer; Richard K Wilson; Li Zhuang; Robert W Dewan; Li Ding; Emmet Huang-Hobbs; Jennifer Y Lee; Keith L Ligon; Gordon B Mills; Lewis C Cantley; Lydia W T Cheung; Lynda Chin
Somatic mutations of PIK3R1 promote gliomagenesis.
PloS one 2012;7(11):e49466.
2011: Alejandro Gutierrez; Linda Holmfeldt; Stephen P Hunger; Alex Kentsis; Frederick W Alt; Shann-Ching Chen; Lynda Chin; Suzanne E Dahlberg; James R Downing; Charles G Mullighan; Donna Neuberg; Alexei Protopopov; Stephen E Sallan; Takaomi Sanda; Lewis B Silverman; Stuart S Winter; Shan Zha; Jianhua Zhang; A Thomas Look
The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia.
Blood 2011;118(15):4169-73.
2011: Kenneth L. Scott; Remco van Doorn; George Vande Woude; Chang-Jiun Wu; Yonghong Xiao; Rhamy Zeid; Marcus W Bosenberg; Lisa A Cameron; Gerald Chu; Ronald A DePinho; Sabin Dhakal; Tamar Feinberg; Scott R Granter; Jason A Hanna; Timothy P Heffernan; Mariela Jaskelioff; Minjung Kim; Chengyin Min; Cristina Nogueira; Samuel R Perry; David L Rimm; Lynda Chin
Proinvasion metastasis drivers in early-stage melanoma are oncogenes.
Cancer cell 2011;20(1):92-103.
2011: Haoqiang Ying; Hailei Zhang; Hongwu Zheng; Stephanie M Zimmerman; Nabeel Bardeesy; Lynda Chin; Gerald Chu; Simona Colla; Kutlu G Elpek; Eliot Fletcher-Sananikone; Aram F Hezel; Shan Jiang; Alec C Kimmelman; Carol Lim; Yingchun Liu; Brian Malinn; Ji-Hye Paik; Samuel R Perry; Alexei Protopopov; Xiaojia Ren; Sarah P Thayer; Shannon J Turley; Anant Vinjamoori; Wei Wang; Y Alan Wang; Yonghong Xiao; Haiyan Yan; Ronald A DePinho
PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine network.
Cancer discovery 2011;1(2):158-69.
2011: Lynda Chin; William C Hahn; Gad Getz; Matthew Meyerson
Making sense of cancer genomic data.
Genes & development 2011;25(6):534-55.
2011: Ergün Sahin; Simona Colla; Marc Liesa; Javid Moslehi; Florian L Müller; Mira Guo; Marcus Cooper; Darrell Kotton; Attila J Fabian; Carl Walkey; richard s maser; Giovanni Tonon; Friedrich Foerster; Robert Xiong; Y Alan Wang; Sachet A Shukla; Mariela Jaskelioff; Eric S Martin; Timothy P Heffernan; Alexei Protopopov; Elena Ivanova; John E Mahoney; Maria Kost-Alimova; Samuel R Perry; Roderick Bronson; Ronglih Liao; Richard Mulligan; Orian S Shirihai; Lynda Chin; Ronald A DePinho
Telomere dysfunction induces metabolic and mitochondrial compromise.
Nature 2011;470(7334):359-65.
2011: Zhihu Ding; Chang-Jiun Wu; Gerald Chu; Yonghong Xiao; Dennis Ho; Jingfang Zhang; Samuel R Perry; Emma S Labrot; Xiaoqiu Wu; Rosina Lis; Yujin Hoshida; David Hiller; Baoli Hu; Shan Jiang; Hongwu Zheng; Alexander H Stegh; Kenneth L Scott; Sabina Signoretti; Nabeel Bardeesy; Y Alan Wang; David E Hill; Todd R Golub; Meir J Stampfer; Wing H Wong; Massimo Loda; Lorelei Mucci; Lynda Chin; Ronald A DePinho
SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression.
Nature 2011;470(7333):269-73.
2010: Boyi Gan; Jian Hu; Shan Jiang; Yingchun Liu; Ergün Sahin; Li Zhuang; Eliot Fletcher-Sananikone; Simona Colla; Y Alan Wang; Lynda Chin; Ronald A DePinho
Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells.
Nature 2010;468(7324):701-4.
2010: Alexander H Stegh; Cameron Brennan; John A Mahoney; Kristin L Forloney; Harry T Jenq; Janina P Luciano; Alexei Protopopov; Lynda Chin; Ronald A DePinho
Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor.
Genes & development 2010;24(19):2194-204.
2010: Alejandro Gutierrez; Suzanne E Dahlberg; Donna S Neuberg; Jianhua Zhang; Ruta Grebliunaite; Takaomi Sanda; Alexei Protopopov; Valeria Tosello; Jeffery L Kutok; Richard Larson; Michael J Borowitz; Mignon L Loh; Adolfo Ferrando; Stuart S Winter; Charles G Mullighan; Lewis B Silverman; Lynda Chin; Stephen P Hunger; Stephen E Sallan; A Thomas Look
Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(24):3816-23.
2010: W Ruprecht Wiedemeyer; Ian F Dunn; Steven N Quayle; Jianhua Zhang; Milan G Chheda; Gavin P Dunn; Li Zhuang; Joseph Rosenbluh; Shujuan Chen; Yonghong Xiao; Geoffrey I Shapiro; William C Hahn; Lynda Chin
Pattern of retinoblastoma pathway inactivation dictates response to CDK4/6 inhibition in GBM.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(25):11501-6.
2010: Hongwu Zheng; Haoqiang Ying; Ruprecht Wiedemeyer; Haiyan Yan; Steven N Quayle; Elena V Ivanova; Ji-Hye Paik; Hailei Zhang; Yonghong Xiao; Samuel R Perry; Jian Hu; Anant Vinjamoori; Boyi Gan; Ergun Sahin; Milan G Chheda; Cameron Brennan; Y Alan Wang; William C Hahn; Lynda Chin; Ronald A DePinho
PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas.
Cancer cell 2010;17(5):497-509.
2010: Haoqiang Ying; Hongwu Zheng; Kenneth Scott; Ruprecht Wiedemeyer; Haiyan Yan; Carol Lim; Joseph Huang; Sabin Dhakal; Elena Ivanova; Yonghong Xiao; Hailei Zhang; Jian Hu; Jayne M Stommel; Michelle A Lee; An-Jou Chen; Ji-Hye Paik; Oreste Segatto; Cameron Brennan; Lisa A Elferink; Y Alan Wang; Lynda Chin; Ronald A DePinho
Mig-6 controls EGFR trafficking and suppresses gliomagenesis.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(15):6912-7.
2010: Alejandro Gutierrez; Takaomi Sanda; Wenxue Ma; Jianhua Zhang; Ruta Grebliunaite; Suzanne Dahlberg; Donna Neuberg; Alexei Protopopov; Stuart S Winter; Richard Larson; Michael J Borowitz; Lewis B Silverman; Lynda Chin; Stephen P Hunger; Catriona Jamieson; Stephen E Sallan; A Thomas Look
Inactivation of LEF1 in T-cell acute lymphoblastic leukemia.
Blood 2010;115(14):2845-51.
2010: Akitake Mukasa; Jill Wykosky; Keith L Ligon; Lynda Chin; Webster K Cavenee; Frank B Furnari
Mutant EGFR is required for maintenance of glioma growth in vivo, and its ablation leads to escape from receptor dependence.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(6):2616-21.
2010: Lawrence N Kwong; Lynda Chin
The brothers RAF.
Cell 2010;140(2):180-2.
2010: Masayuki Nitta; David Kozono; Richard Kennedy; Jayne Stommel; Kimberly Ng; Pascal O Zinn; Deepa Kushwaha; Santosh kesari; Frank Furnari; Katherine A Hoadley; Lynda Chin; Ronald A DePinho; Webster K Cavenee; Alan D'Andrea; Maria-del-Mar Inda; Jill Wykosky; Clark C Chen
Targeting EGFR induced oxidative stress by PARP1 inhibition in glioblastoma therapy.
PloS one 2010;5(5):e10767.
2010: Omar Kabbarah; Cristina Nogueira; Bin Feng; Rosalynn M Nazarian; Marcus W Bosenberg; Min Wu; Kenneth L Scott; Lawrence N Kwong; Yonghong Xiao; Carlos Cordon-Cardo; Scott R Granter; Sridhar Ramaswamy; Todd R Golub; Lyn M Duncan; Stephan N Wagner; Cameron Brennan; Lynda Chin
Integrative genome comparison of primary and metastatic melanomas.
PloS one 2010;5(5):e10770.
2009: Ji-hye Paik; Zhihu Ding; Rujuta Narurkar; Shakti Ramkissoon; Florian Muller; Walid S Kamoun; Sung-Suk Chae; Hongwu Zheng; Haoqiang Ying; Jed Mahoney; David Hiller; Shan Jiang; Alexei Protopopov; Wing H Wong; Lynda Chin; Keith L Ligon; Ronald A DePinho
FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis.
Cell stem cell 2009;5(5):540-53.
2009: Alejandro Gutierrez; Takaomi Sanda; Ruta Grebliunaite; Arkaitz Carracedo; Leonardo Salmena; Yebin Ahn; Suzanne Dahlberg; Donna Neuberg; Lisa A Moreau; Stuart S Winter; Richard Larson; Jianhua Zhang; Alexei Protopopov; Lynda Chin; Pier Paolo Pandolfi; Lewis B Silverman; Stephen P Hunger; Stephen E Sallan; A Thomas Look
High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia.
Blood 2009;114(3):647-50.
2009: Kenneth L. Scott; Omar Kabbarah; Mei-Chih Liang; Elena Ivanova; Valsamo Anagnostou; Joyce Wu; Sabin Dhakal; Min Wu; Shujuan Chen; Tamar Feinberg; Joseph Huang; Abdel Saci; Hans R Widlund; David E Fisher; Yonghong Xiao; David L Rimm; Alexei Protopopov; Kwok-Kin Wong; Lynda Chin
GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer.
Nature 2009;459(7250):1085-90.
2009: Lawrence N Kwong; Lynda Chin
The metastasis problem gets stickier.
Cancer cell 2009;15(1):1-2.
2008: Boyi Gan; Ergün Sahin; Shan Jiang; Abel Sanchez-Aguilera; Kenneth L. Scott; Lynda Chin; David A Williams; David J Kwiatkowski; Ronald A DePinho
mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(49):19384-9.
2008: Alec C Kimmelman; Aram F Hezel; Andrew J Aguirre; Hongwu Zheng; Ji-Hye Paik; Haoqiang Ying; Gerald Chu; Jean X Zhang; Ergun Sahin; Giminna Yeo; Aditya Ponugoti; Roustem Nabioullin; Scott Deroo; Shenghong Yang; Xiaoxu Wang; John P McGrath; Marina Protopopova; Elena Ivanova; Jianhua Zhang; Bin Feng; Ming Tsao; Mark Redston; Alexei Protopopov; Yonghong Xiao; P Andrew Futreal; William C Hahn; David S Klimstra; Lynda Chin; Ronald A DePinho
Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(49):19372-7.
2008: Hongwu Zheng; Haoqiang Ying; Haiyan Yan; Alec C Kimmelman; David J Hiller; An-Jou Chen; Samuel R Perry; Giovanni Tonon; Gerald Chu; Zhihu Ding; Jayne M Stommel; Katherine L Dunn; Ruprecht Wiedemeyer; Mingjian J You; Cameron Brennan; Y Alan Wang; Keith L Ligon; Wing H Wong; Lynda Chin; Ronald A DePinho
p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation.
Nature 2008;455(7216):1129-33.
2008: Alexander H Stegh; Lynda Chin; David N Louis; Ronald A DePinho
What drives intense apoptosis resistance and propensity for necrosis in glioblastoma? A role for Bcl2L12 as a multifunctional cell death regulator.
Cell cycle (Georgetown, Tex.) 2008;7(18):2833-9.
2008: Alexander H Stegh; Santosh kesari; John E Mahoney; Harry T Jenq; Kristin L Forloney; Alexei Protopopov; David N Louis; Lynda Chin; Ronald A DePinho
Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(31):10703-8.
2008: Hye-Min Jeon; Xun Jin; Joong-Seob Lee; Se-Yeong Oh; Young-Woo Sohn; Hyo-Jung Park; Kyeung Min Joo; Woong-Yang Park; Do-Hyun Nam; Ronald A DePinho; Lynda Chin; Hyunggee Kim
Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling.
Genes & development 2008;22(15):2028-33.
2008: Lynda Chin; Joe Gray
Translating insights from the cancer genome into clinical practice.
Nature 2008;452(7187):553-63.
2008: Ruprecht Wiedemeyer; Cameron Brennan; Timothy P Heffernan; Yonghong Xiao; John Mahoney; Alexei Protopopov; Hongwu Zheng; Graham Bignell; Frank B Furnari; Webster K Cavenee; William C Hahn; Koichi Ichimura; V Peter Collins; Gerald Chu; Michael R Stratton; Keith L Ligon; P Andrew Futreal; Lynda Chin
Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development.
Cancer cell 2008;13(4):355-64.
2008: Samanthi A Perera; richard s maser; Huili Xia; Kate McNamara; Alexei Protopopov; Liang Chen; Aram F Hezel; Carla F. Kim; Roderick T Bronson; Diego H Castrillon; Lynda Chin; Nabeel Bardeesy; Ronald A DePinho; Kwok-Kin Wong
Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer.
Carcinogenesis 2008;29(4):747-53.
2008: H Zheng; H Ying; H Yan; Alec C Kimmelman; D J Hiller; A-J Chen; S R Perry; G Tonon; Gerald Chu; Z Ding; J M Stommel; K L Dunn; Ruprecht Wiedemeyer; M J You; Cameron Brennan; Y A Wang; K L Ligon; W H Wong; Lynda Chin; Ronald A DePinho
Pten and p53 converge on c-Myc to control differentiation, self-renewal, and transformation of normal and neoplastic stem cells in glioblastoma.
Cold Spring Harbor symposia on quantitative biology 2008;73():427-37.
2008: Alexei Protopopov; Bin Feng; Lynda Chin
Full complexity genomic hybridization on 60-mer oligonucleotide microarrays for array comparative genomic hybridization (aCGH).
Methods in molecular biology (Clifton, N.J.) 2008;439():87-100.
2007: Jennifer O'Neil; Joëlle Tchinda; Alejandro Gutierrez; Lisa A Moreau; richard s maser; Kwok-Kin Wong; Wei Li; Keith McKenna; Xiaole (Shirley) Liu; Bin Feng; Donna Neuberg; Lewis B Silverman; Daniel J DeAngelo; Jeffery L Kutok; Rodney Rothstein; Ronald A DePinho; Lynda Chin; Charles Lee; A Thomas Look
Alu elements mediate MYB gene tandem duplication in human T-ALL.
The Journal of experimental medicine 2007;204(13):3059-66.
2007: Tae Kyoung Kim; Joong-Seob Lee; Se-Yeong Oh; Xun Jin; Yun-Jaie Choi; Tae-Hoon Lee; Eun ho Lee; Young-Ki Choi; Seungkwon You; Yong Gu Chung; Jang-Bo Lee; Ronald A DePinho; Lynda Chin; Hyunggee Kim
Direct transcriptional activation of promyelocytic leukemia protein by IFN regulatory factor 3 induces the p53-dependent growth inhibition of cancer cells.
Cancer research 2007;67(23):11133-40.
2007: Eric S Martin; Giovanni Tonon; Raktim Sinha; Yonghong Xiao; Bin Feng; Alec C Kimmelman; Alexei Protopopov; Elena Ivanova; Cameron Brennan; Kate Montgomery; Raju Kucherlapati; Gerald Bailey; Mark Redston; Lynda Chin; Ronald A DePinho
Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types.
Cancer research 2007;67(22):10736-43.
2007: Frank B Furnari; Tim Fenton; Robert M Bachoo; Akitake Mukasa; Jayne M Stommel; Alexander H Stegh; William C Hahn; Keith L Ligon; David N Louis; Cameron Brennan; Lynda Chin; Ronald A DePinho; Webster K Cavenee
Malignant astrocytic glioma: genetics, biology, and paths to treatment.
Genes & development 2007;21(21):2683-710.
2007: Joel Greshock; Bin Feng; Cristina Nogueira; Elena Ivanova; Ilana Perna; Katherine L Nathanson; Alexei Protopopov; Barbara L Weber; Lynda Chin
A comparison of DNA copy number profiling platforms.
Cancer research 2007;67(21):10173-80.
2007: Jayne M Stommel; Alec C Kimmelman; Haoqiang Ying; Roustem Nabioullin; Aditya H Ponugoti; Ruprecht Wiedemeyer; Alexander H Stegh; James E Bradner; Keith L Ligon; Cameron Brennan; Lynda Chin; Ronald A DePinho
Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies.
Science (New York, N.Y.) 2007;318(5848):287-90.
2007: richard s maser; Bhudipa Choudhury; Peter J Campbell; Bin Feng; Kwok-Kin Wong; Alexei Protopopov; Jennifer O'Neil; Alejandro Gutierrez; Elena Ivanova; Ilana Perna; Eric Lin; Vidya Mani; Shan Jiang; Kate McNamara; Sara Zaghlul; Sarah Edkins; Claire Stevens; Cameron Brennan; Eric S Martin; Ruprecht Wiedemeyer; Omar Kabbarah; Cristina Nogueira; Gavin Histen; Jon Aster; Marc Mansour; Veronique Duke; Letizia Foroni; Adele K Fielding; Anthony H Goldstone; Jacob M Rowe; Yaoqi A Wang; A Thomas Look; Michael R Stratton; Lynda Chin; P Andrew Futreal; Ronald A DePinho
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers.
Nature 2007;447(7147):966-71.
2007: Hongbin Ji; Zhenxiong Wang; Samanthi A Perera; Danan Li; Mei-Chih Liang; Sara Zaghlul; Kate McNamara; Liang Chen; Mitchell S Albert; Yanping Sun; Ruqayyah Al-Hashem; Lucian R Chirieac; Robert F Padera; Roderick T Bronson; Roman K Thomas; Levi A Garraway; Pasi A Janne; Bruce E Johnson; Lynda Chin; Kwok-Kin Wong
Mutations in BRAF and KRAS converge on activation of the mitogen-activated protein kinase pathway in lung cancer mouse models.
Cancer research 2007;67(10):4933-9.
2007: Miguel N Rivera; Woo Jae Kim; Julie Wells; David R Driscoll; Brian W Brannigan; Moonjoo Han; James C Kim; Andrew P Feinberg; William L Gerald; Sara O Vargas; Lynda Chin; A John Iafrate; Daphne W Bell; Daniel A Haber
An X chromosome gene, WTX, is commonly inactivated in Wilms tumor.
Science (New York, N.Y.) 2007;315(5812):642-5.
2007: Ji-Hye Paik; Ramya Kollipara; Gerald Chu; Hongkai Ji; Yonghong Xiao; Zhihu Ding; Lili Miao; Zuzana Tothova; James W Horner; Daniel R Carrasco; Shan Jiang; D Gary Gilliland; Lynda Chin; Wing H Wong; Diego H Castrillon; Ronald A DePinho
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis.
Cell 2007;128(2):309-23.
2007: Lawrence N Kwong; Lynda Chin; Stephan N Wagner
Growth factors and oncogenes as targets in melanoma: lost in translation?
Advances in dermatology 2007;23():99-129.
2007: Alexander H Stegh; Hyunggee Kim; Robert M Bachoo; Kristin L Forloney; Jean Zhang; Harald Schulze; Kevin Park; Gregory J Hannon; Junying Yuan; David N Louis; Ronald A DePinho; Lynda Chin
Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma.
Genes & development 2007;21(1):98-111.
2006: Elizabeth A Maher; Cameron Brennan; Patrick Y Wen; Laura Durso; Keith L Ligon; Aaron Richardson; Deepak Khatry; Bin Feng; Raktim Sinha; David N Louis; John Quackenbush; Peter Black; Lynda Chin; Ronald A DePinho
Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities.
Cancer research 2006;66(23):11502-13.
2006: Fenghua Liu; Peter J Park; Weil Lai; Elizabeth Maher; Arnab Chakravarti; Laura Durso; Xiuli Jiang; Yi Yu; Amanda Brosius; Meredith Thomas; Lynda Chin; Cameron Brennan; Ronald A DePinho; Isaac Kohane; Rona S Carroll; Peter M Black; Mark D Johnson
A genome-wide screen reveals functional gene clusters in the cancer genome and identifies EphA2 as a mitogen in glioblastoma.
Cancer research 2006;66(22):10815-23.
2006: Lynda Chin; Levi A Garraway; David E Fisher
Malignant melanoma: genetics and therapeutics in the genomic era.
Genes & development 2006;20(16):2149-82.
2006: Minjung Kim; Joseph D Gans; Cristina Nogueira; Audrey Wang; Ji-Hye Paik; Bin Feng; Cameron Brennan; William C Hahn; Carlos Cordon-Cardo; Stephan N Wagner; Thomas J Flotte; Lyn M Duncan; Scott R Granter; Lynda Chin
Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene.
Cell 2006;125(7):1269-81.
2006: Marcus W Bosenberg; Viswanathan Muthusamy; David P Curley; Zhenxiong Wang; Cara Hobbs; Betsy Nelson; Cristina Nogueira; James W Horner; Ronald A DePinho; Lynda Chin
Characterization of melanocyte-specific inducible Cre recombinase transgenic mice.
Genesis (New York, N.Y. : 2000) 2006;44(5):262-7.
2006: Viswanathan Muthusamy; Cara Hobbs; Cristina Nogueira; Carlos Cordon-Cardo; Phillip H McKee; Lynda Chin; Marcus W Bosenberg
Amplification of CDK4 and MDM2 in malignant melanoma.
Genes, chromosomes & cancer 2006;45(5):447-54.
2006: Nabeel Bardeesy; Andrew J Aguirre; Gerald Chu; Kuang-hung Cheng; Lyle V Lopez; Aram F Hezel; Bin Feng; Cameron Brennan; Ralph Weissleder; Umar Mahmood; Douglas Hanahan; Mark Redston; Lynda Chin; Ronald A DePinho
Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(15):5947-52.
2006: Daniel R Carrasco; Giovanni Tonon; Yongsheng Huang; Yunyu Zhang; Raktim Sinha; Bin Feng; James P Stewart; Fenghuang Zhan; Deepak Khatry; Marina Protopopova; Alexei Protopopov; Kumar Sukhdeo; Ichiro Hanamura; Owen Stephens; Bart Barlogie; Kenneth C Anderson; Lynda Chin; John D Shaughnessy; Cameron Brennan; Ronald A DePinho
High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients.
Cancer cell 2006;9(4):313-25.
2006: Gromoslaw A Smolen; Beth Muir; Gayatry Mohapatra; Anne Barmettler; Woo J Kim; Miguel N Rivera; Sara M Haserlat; Ross A Okimoto; Eunice L Kwak; Sonika Dahiya; Judy E Garber; Daphne W Bell; Dennis C Sgroi; Lynda Chin; Chu-Xia Deng; Daniel A Haber
Frequent met oncogene amplification in a Brca1/Trp53 mouse model of mammary tumorigenesis.
Cancer research 2006;66(7):3452-5.
2006: Omar Kabbarah; Lynda Chin
Advances in malignant melanoma: genetic insights from mouse and man.
Frontiers in bioscience : a journal and virtual library 2006;11():928-42.
2005: Omar Kabbarah; Lynda Chin
Revealing the genomic heterogeneity of melanoma.
Cancer cell 2005;8(6):439-41.
2005: Elisabeth A Seftor; Kevin Brown; Lynda Chin; Dawn A Kirschmann; William W Wheaton; Alexei Protopopov; Bin Feng; yoganand balagurunathan; Jeffrey M. Trent; Brian J Nickoloff; Richard E B Seftor; Mary J C Hendrix
Epigenetic transdifferentiation of normal melanocytes by a metastatic melanoma microenvironment.
Cancer research 2005;65(22):10164-9.
2005: Yi Tang; Minjung Kim; Daniel Carrasco; Andrew L Kung; Lynda Chin; Ralph Weissleder
In vivo assessment of RAS-dependent maintenance of tumor angiogenesis by real-time magnetic resonance imaging.
Cancer research 2005;65(18):8324-30.
2005: William H Tolleson; Jason C Doss; John R Latendresse; Alan Warbritton; William B Melchior; Lynda Chin; Richard R Dubielzig; Daniel M Albert
Spontaneous uveal amelanotic melanoma in transgenic Tyr-RAS+ Ink4a/Arf-/- mice.
Archives of ophthalmology 2005;123(8):1088-94.
2005: Giovanni Tonon; Kwok-Kin Wong; Gautam Maulik; Cameron Brennan; Bin Feng; Yunyu Zhang; Deepak Khatry; Alexei Protopopov; Mingjian James You; Andrew J Aguirre; Eric S Martin; Zhaohui Yang; Hongbin Ji; Lynda Chin; Ronald A DePinho
High-resolution genomic profiles of human lung cancer.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(27):9625-30.
2005: Yuxun Wang; Christopher D Putnam; Michael F Kane; Weijia Zhang; Lisa Edelmann; Robert Russell; Danaise V Carrión; Lynda Chin; Raju Kucherlapati; Richard D Kolodner; Winfried Edelmann
Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice.
Nature genetics 2005;37(7):750-5.
2005: Thomas F Westbrook; Eric S Martin; Michael R Schlabach; Yumei Leng; Anthony C Liang; Bin Feng; Jean J Zhao; Thomas M Roberts; Gail Mandel; Gregory J Hannon; Ronald A DePinho; Lynda Chin; Stephen J Elledge
A genetic screen for candidate tumor suppressors identifies REST.
Cell 2005;121(6):837-48.
2005: Nabeel Bardeesy; Minjung Kim; Jin Xu; Ryung S. Kim; Qiong Shen; Marcus W Bosenberg; Wing H Wong; Lynda Chin
Role of epidermal growth factor receptor signaling in RAS-driven melanoma.
Molecular and cellular biology 2005;25(10):4176-88.
2005: Giovanni Tonon; Cameron Brennan; Alexei Protopopov; Gautam Maulik; Bin Feng; Yunyu Zhang; Deepak Khatry; Mingjian James You; Andrew J Aguirre; Eric S Martin; Z Yang; Hongbin Ji; Lynda Chin; Kwok-Kin Wong; Ronald A DePinho
Common and contrasting genomic profiles among the major human lung cancer subtypes.
Cold Spring Harbor symposia on quantitative biology 2005;70():11-24.
2004: Gang Wang; Elizabeth Maher; Cameron Brennan; Lynda Chin; Christopher Leo; Manjit Kaur; Penny Zhu; Martha Rook; Jia Liu Wolfe; Michael G Makrigiorgos
DNA amplification method tolerant to sample degradation.
Genome research 2004;14(11):2357-66.
2004: Robert Blelloch; Konrad Hochedlinger; Yasuhiro Yamada; Cameron Brennan; Minjung Kim; Beatrice Mintz; Lynda Chin; Rudolf Jaenisch
Nuclear cloning of embryonal carcinoma cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(39):13985-90.
2004: Konrad Hochedlinger; Robert Blelloch; Cameron Brennan; Yasuhiro Yamada; Minjung Kim; Lynda Chin; Rudolf Jaenisch
Reprogramming of a melanoma genome by nuclear transplantation.
Genes & development 2004;18(15):1875-85.
2004: Cameron Brennan; Yunyu Zhang; Christopher Leo; Bin Feng; Craig Cauwels; Andrew J Aguirre; Minjung Kim; Alexei Protopopov; Lynda Chin
High-resolution global profiling of genomic alterations with long oligonucleotide microarray.
Cancer research 2004;64(14):4744-8.
2004: Minna Allinen; Rameen Beroukhim; Li Cai; Cameron Brennan; Jaana Lahti-Domenici; Haiyan Huang; Dale Porter; Min Hu; Lynda Chin; Andrea Richardson; Stuart J Schnitt; William R Sellers; Kornelia Polyak
Molecular characterization of the tumor microenvironment in breast cancer.
Cancer cell 2004;6(1):17-32.
2004: Andrew J Aguirre; Cameron Brennan; Gerald Bailey; Raktim Sinha; Bin Feng; Christopher Leo; Yunyu Zhang; Jean Zhang; Joseph D Gans; Nabeel Bardeesy; Craig Cauwels; Carlos Cordon-Cardo; Mark Redston; Ronald A DePinho; Lynda Chin
High-resolution characterization of the pancreatic adenocarcinoma genome.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(24):9067-72.
2004: Gang Wang; Cameron Brennan; Martha Rook; Jia Liu Wolfe; Christopher Leo; Lynda Chin; Hongjie Pan; Wei-Hua Liu; Brendan Price; Michael G Makrigiorgos
Balanced-PCR amplification allows unbiased identification of genomic copy changes in minute cell and tissue samples.
Nucleic acids research 2004;32(9):e76.
2003: Rónán C O'Hagan; Cameron Brennan; Andrew Strahs; Xuegong Zhang; Karuppiah Kannan; Melissa Donovan; Craig Cauwels; Norman E Sharpless; Wing Hung Wong; Lynda Chin
Array comparative genome hybridization for tumor classification and gene discovery in mouse models of malignant melanoma.
Cancer research 2003;63(17):5352-6.
2003: Norman E Sharpless; Karuppiah Kannan; Jin Xu; Marcus W Bosenberg; Lynda Chin
Both products of the mouse Ink4a/Arf locus suppress melanoma formation in vivo.
Oncogene 2003;22(32):5055-9.
2003: Lynda Chin
The genetics of malignant melanoma: lessons from mouse and man.
Nature reviews. Cancer 2003;3(8):559-70.
2003: E Sharpless; Lynda Chin
The INK4a/ARF locus and melanoma.
Oncogene 2003;22(20):3092-8.
2003: Karuppiah Kannan; Norman E Sharpless; Jin Xu; Rónán C O'Hagan; Marcus W Bosenberg; Lynda Chin
Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):1221-5.
2002: Meenhard Herlyn; Martin Padarathsingh; Lynda Chin; Mary Hendrix; Dorothea Becker; Mark Nelson; Yves A DeClerck; James McCarthy; Suresh Mohla
New approaches to the biology of melanoma: a workshop of the National Institutes of Health Pathology B Study Section.
The American journal of pathology 2002;161(5):1949-57.
2002: Rónán C O'Hagan; Sandy Chang; richard s maser; Ramya Mohan; Steven E Artandi; Lynda Chin; Ronald A DePinho
Telomere dysfunction provokes regional amplification and deletion in cancer genomes.
Cancer cell 2002;2(2):149-55.
2002: Dale Porter; Jaana Lahti-Domenici; Marisa Torres-Arzayus; Lynda Chin; Kornelia Polyak
Expression of high in normal-1 (HIN-1) and uteroglobin related protein-1 (UGRP-1) in adult and developing tissues.
Mechanisms of development 2002;114(1-2):201-4.
2002: Elena V Sviderskaya; Simon P Hill; Tracy Evans-Whipp; Lynda Chin; Seth J Orlow; David J Easty; Sok Ching Cheong; David Beach; Ronald A DePinho; Dorothy C Bennett
p16(Ink4a) in melanocyte senescence and differentiation.
Journal of the National Cancer Institute 2002;94(6):446-54.
2002: Mingjian James You; Diego H Castrillon; Boris C Bastian; Rónán C O'Hagan; Marcus W Bosenberg; Ramon Parsons; Lynda Chin; Ronald A DePinho
Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(3):1455-60.
2001: Norman E Sharpless; David O Ferguson; Rónán C O'Hagan; Diego H Castrillon; C Lee; P A Farazi; Scott Alson; J Fleming; C C Morton; K Frank; Lynda Chin; Frederick W Alt; Ronald A DePinho
Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions.
Molecular cell 2001;8(6):1187-96.
2001: Jinming Yang; Jing Luan; Yingchun Yu; C Li; Ronald A DePinho; Lynda Chin; Ann Richmond
Induction of melanoma in murine macrophage inflammatory protein 2 transgenic mice heterozygous for inhibitor of kinase/alternate reading frame.
Cancer research 2001;61(22):8150-7.
2001: Michael T Hemann; K L Rudolph; Margaret A Strong; Ronald A DePinho; Lynda Chin; Carol W Greider
Telomere dysfunction triggers developmentally regulated germ cell apoptosis.
Molecular biology of the cell 2001;12(7):2023-30.
2001: Alex Wong; M Alfert; Diego H Castrillon; Q Shen; J Holash; G D Yancopoulos; Lynda Chin
Excessive tumor-elaborated VEGF and its neutralization define a lethal paraneoplastic syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7481-6.
2001: F C Yang; Glenn Merlino; Lynda Chin
Genetic dissection of melanoma pathways in the mouse.
Seminars in cancer biology 2001;11(3):261-8.
2001: K H Lee; K Lenhard Rudolph; Y J Ju; Roger A. Greenberg; Linda Cannizzaro; Lynda Chin; Sarah R Weiler; Ronald A DePinho
Telomere dysfunction alters the chemotherapeutic profile of transformed cells.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3381-6.
2001: X Q Lu; John L Humm; Lynda Chin
Estimate of absorbed dose based on two-dimensional autoradiographic information in internal radionuclide therapy.
Medical physics 2001;28(3):328-35.
2001: Nabeel Bardeesy; Boris C Bastian; Aram F Hezel; D Pinkel; Ronald A DePinho; Lynda Chin
Dual inactivation of RB and p53 pathways in RAS-induced melanomas.
Molecular and cellular biology 2001;21(6):2144-53.
2001: Yi Lu; H Lian; P Sharma; N Schreiber-Agus; Robert G Russell; Lynda Chin; G T van der Horst; David B Bregman
Disruption of the Cockayne syndrome B gene impairs spontaneous tumorigenesis in cancer-predisposed Ink4a/ARF knockout mice.
Molecular and cellular biology 2001;21(5):1810-8.
2000: M K Tietze; Lynda Chin
Murine models of malignant melanoma.
Molecular medicine today 2000;6(10):408-10.
2000: Kwok-Kin Wong; S Chang; Sarah R Weiler; S Ganesan; Jayanta Chaudhuri; C Zhu; Steven E Artandi; K Lenhard Rudolph; GJ Gottlieb; Lynda Chin; Frederick W Alt; Ronald A DePinho
Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation.
Nature genetics 2000;26(1):85-8.
2000: Steven E Artandi; S Chang; S L Lee; Scott Alson; GJ Gottlieb; Lynda Chin; Ronald A DePinho
Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice.
Nature 2000;406(6796):641-5.
2000: Lynda Chin; Ronald A DePinho
Flipping the oncogene switch: illumination of tumor maintenance and regression.
Trends in genetics : TIG 2000;16(4):147-50.
2000: Alex Wong; Lynda Chin
An inducible melanoma model implicates a role for RAS in tumor maintenance and angiogenesis.
Cancer metastasis reviews 2000;19(1-2):121-9.
2000: Nabeel Bardeesy; Kwok-Kin Wong; Ronald A DePinho; Lynda Chin
Animal models of melanoma: recent advances and future prospects.
Advances in cancer research 2000;79():123-56.
1999: Lynda Chin
Modeling malignant melanoma in mice: pathogenesis and maintenance.
Oncogene 1999;18(38):5304-10.
1999: Lynda Chin; A Tam; J Pomerantz; M Wong; J Holash; Nabeel Bardeesy; Q Shen; Rónán C O'Hagan; J Pantginis; H Zhou; James W Horner; Carlos Cordon-Cardo; G D Yancopoulos; Ronald A DePinho
Essential role for oncogenic Ras in tumour maintenance.
Nature 1999;400(6743):468-72.
1999: Irene Orlow; Farhang Rabbani; Lynda Chin; J Pomerantz; N Ligeois; Maria E Dudas; Ronald A DePinho; C Cordón-Cardó
Involvement of the Ink4a gene (p16 and p19arf) in murine tumorigenesis.
International journal of oncology 1999;15(1):17-24.
1999: Lynda Chin; Steven E Artandi; Q Shen; A Tam; S L Lee; GJ Gottlieb; Carol W Greider; Ronald A DePinho
p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis.
Cell 1999;97(4):527-38.
1999: Roger A. Greenberg; Lynda Chin; Andrea M Femino; K H Lee; G J Gottlieb; Robert H Singer; Carol W Greider; Ronald A DePinho
Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse.
Cell 1999;97(4):515-25.
1999: MJ FitzGerald; Marcello Arsura; RE Bellas; W Yang; M Wu; Lynda Chin; Koren K Mann; Ronald A DePinho; Gail E Sonenshein
Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc.
Oncogene 1999;18(15):2489-98.
1999: Roger A. Greenberg; Rónán C O'Hagan; H Deng; Q Xiao; S R Hann; R R Adams; SP Lichtsteiner; Lynda Chin; Gregg B Morin; Ronald A DePinho
Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation.
Oncogene 1999;18(5):1219-26.
1998: Lynda Chin; G Merlino; Ronald A DePinho
Malignant melanoma: modern black plague and genetic black box.
Genes & development 1998;12(22):3467-81.
1998: Lynda Chin; J Pomerantz; Ronald A DePinho
The INK4a/ARF tumor suppressor: one gene--two products--two pathways.
Trends in biochemical sciences 1998;23(8):291-6.
1998: Roger A. Greenberg; Rich Allsopp; Lynda Chin; Gregg B Morin; Ronald A DePinho
Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation.
Oncogene 1998;16(13):1723-30.
1998: J Pomerantz; N Schreiber-Agus; NANETTE LIEGEOIS; A Silverman; Leila Alland; Lynda Chin; Jason Potes; Ken Chen; Irene Orlow; H W Lee; Carlos Cordon-Cardo; Ronald A DePinho
The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53.
Cell 1998;92(6):713-23.
1997: Lynda Chin; J Pomerantz; D Polsky; M Jacobson; C Cohen; Carlos Cordon-Cardo; James W Horner; Ronald A DePinho
Cooperative effects of INK4a and ras in melanoma susceptibility in vivo.
Genes & development 1997;11(21):2822-34.
1997: Leila Alland; Rebecca Muhle; Harry Hou; Jason Potes; Lynda Chin; N Schreiber-Agus; Ronald A DePinho
Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression.
Nature 1997;387(6628):49-55.
1996: M Serrano; H Lee; Lynda Chin; C Cordon-Cardo; D Beach; Ronald A DePinho
Role of the INK4a locus in tumor suppression and cell mortality.
Cell 1996;85(1):27-37.
1996: Lynda Chin; NANETTE LIEGEOIS; Ronald A DePinho; N Schreiber-Agus
Functional interactions among members of the Myc superfamily and potential relevance to cutaneous growth and development.
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 1996;1(2):128-35.
1996: K S Hatton; Kathleen A Mahon; Lynda Chin; Fungchow A Chiu; H W Lee; D Peng; S D Morgenbesser; J Horner; Ronald A DePinho
Expression and activity of L-Myc in normal mouse development.
Molecular and cellular biology 1996;16(4):1794-804.
1996: G Rao; Leila Alland; P Guida; N Schreiber-Agus; Ken Chen; Lynda Chin; J M Rochelle; Michael F Seldin; Arthur I Skoultchi; Ronald A DePinho
Mouse Sin3A interacts with and can functionally substitute for the amino-terminal repression of the Myc antagonist Mxi1.
Oncogene 1996;12(5):1165-72.
1995: X Q Lu; Lynda Chin
A direct approach for the determination of absorbed dose from electron beams using non-water phantoms.
Medical physics 1995;22(12):2083-91.
1995: Lynda Chin; N Schreiber-Agus; I Pellicer; Ken Chen; H W Lee; M Dudast; Carlos Cordon-Cardo; Ronald A DePinho
Contrasting roles for Myc and Mad proteins in cellular growth and differentiation.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(18):8488-92.
1995: N Schreiber-Agus; Lynda Chin; Ken Chen; R Torres; G Rao; P Guida; Arthur I Skoultchi; Ronald A DePinho
An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3.
Cell 1995;80(5):777-86.
1995: D J Gladstone; Lynda Chin
Real-time, in vivo measurement of radiation dose during radioimmunotherapy in mice using a miniature MOSFET dosimeter probe.
Radiation research 1995;141(3):330-5.
1995: John L Humm; R M Macklis; X Q Lu; Y Yang; K Bump; B Beresford; Lynda Chin
The spatial accuracy of cellular dose estimates obtained from 3D reconstructed serial tissue autoradiographs.
Physics in medicine and biology 1995;40(1):163-80.
1994: N Schreiber-Agus; Lynda Chin; Ken Chen; R Torres; C T Thomson; J C Sacchettini; Ronald A DePinho
Evolutionary relationships and functional conservation among vertebrate Max-associated proteins: the zebra fish homolog of Mxi1.
Oncogene 1994;9(11):3167-77.
1994: D J Gladstone; X Q Lu; John L Humm; H F Bowman; Lynda Chin
A miniature MOSFET radiation dosimeter probe.
Medical physics 1994;21(11):1721-8.
1994: John L Humm; R M Macklis; Y Yang; K Bump; Lynda Chin
Image analysis for the study of radionuclide distribution in tissue sections.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1994;35(7):1217-25.
1993: John L Humm; R M Macklis; K Bump; L M Cobb; Lynda Chin
Internal dosimetry using data derived from autoradiographs.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1993;34(10):1811-7.
1993: D J Gladstone; Marcel van Herk; Lynda Chin
Verification of lung attenuator positioning before total body irradiation using an electronic portal imaging device.
International journal of radiation oncology, biology, physics 1993;27(2):449-54.
1993: Eric E Klein; Lynda Chin; R K Rice; B J Mijnheer
The influence of air cavities on interface doses for photon beams.
International journal of radiation oncology, biology, physics 1993;27(2):419-27.
1993: John L Humm; Lynda Chin
A model of cell inactivation by alpha-particle internal emitters.
Radiation research 1993;134(2):143-50.
1993: H Rashid; B E Bjarngard; Lynda Chin; R K Rice
Dosimetry of 125I sources in a low-density material using scaling.
Medical physics 1993;20(3):765-8.
1993: X Q Lu; Lynda Chin
Sampling techniques for the evaluation of treatment plans.
Medical physics 1993;20(1):151-61.
1992: K Teramoto; Lynda Chin; U Khettry; Melvin Clouse
Abrogation of ongoing rejection by bromodeoxyuridine, 5-fluorouracil, and low-dose irradiation in heterotopic rat heart transplantation.
Transplantation 1992;54(6):1099-101.
1992: C H Obcemea; R K Rice; B J Mijnheer; R L Siddon; Nancy J Tarbell; Peter M Mauch; Lynda Chin
Three-dimensional dose distribution of total body irradiation by a dual source total body irradiator.
International journal of radiation oncology, biology, physics 1992;24(4):789-93.
1991: D J Gladstone; Lynda Chin
Automated data collection and analysis system for MOSFET radiation detectors.
Medical physics 1991;18(3):542-8.
1990: John L Humm; Lynda Chin; R M Macklis
F(ab')2 fragments versus intact antibody--an isodose comparison.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1990;31(6):1045-7.
1990: R K Rice; Lynda Chin
Monte Carlo calculations of scatter to primary ratios for normalisation of primary and scatter dose.
Physics in medicine and biology 1990;35(3):333-8.
1990: Nancy J Tarbell; Eva C Guinan; Lynda Chin; Peter M Mauch; Howard J Weinstein
Renal insufficiency after total body irradiation for pediatric bone marrow transplantation.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 1990;18 Suppl 1():139-42.
1989: Lynda Chin; CW Cheng; R L Siddon; R K Rice; B J Mijnheer; Jay R Harris
Three-dimensional photon dose distributions with and without lung corrections for tangential breast intact treatments.
International journal of radiation oncology, biology, physics 1989;17(6):1327-35.
1989: B J Mijnheer; Lynda Chin
The effect of differences in data base on the determination of absorbed dose in high-energy photon beams using the American Association of Physicists in Medicine protocol.
Medical physics 1989;16(1):119-22.
1988: R K Rice; Jorgen Hansen; Lynda Chin; B J Mijnheer; B E Bjärngard
The influence of ionization chamber and phantom design on the measurement of lung dose in photon beams.
Medical physics 1988;15(6):884-90.
1988: Lynda Chin; W Harter; G K Svensson; J R Cassady
An external beam treatment technique for retinoblastoma.
International journal of radiation oncology, biology, physics 1988;15(2):455-60.
1988: R K Rice; B J Mijnheer; Lynda Chin
Benchmark measurements for lung dose corrections for X-ray beams.
International journal of radiation oncology, biology, physics 1988;15(2):399-409.
1988: B J Mijnheer; R K Rice; Lynda Chin
Lead-polystyrene transition zone dosimetry in high-energy photon beams.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 1988;11(4):379-86.
1988: EA Bump; S M Pierce; C H Obcemea; Lynda Chin; C Norman Coleman
Effect of OH scavenging on the yield of radiation-induced DNA double-strand breaks in isolated nuclei.
Basic life sciences 1988;49():429-32.
1987: CW Cheng; Lynda Chin
A computer-aided treatment planning technique for universal wedges.
International journal of radiation oncology, biology, physics 1987;13(12):1927-35.
1987: CW Cheng; Lynda Chin; Peter Kijewski
A coordinate transfer of anatomical information from CT to treatment simulation.
International journal of radiation oncology, biology, physics 1987;13(10):1559-69.
1987: P L Petti; R K Rice; B J Mijnheer; Lynda Chin; B E Bjärngard
Heterogeneity model for photon beams incorporating electron transport.
Medical physics 1987;14(3):349-54.
1986: P H Huang; Lynda Chin; B E Bjärngard
Scattered photons produced by beam-modifying filters.
Medical physics 1986;13(1):57-63.
1985: Lynda Chin; R L Siddon; G K Svensson; C Rose
Progress in 3-D treatment planning for photon beam therapy.
International journal of radiation oncology, biology, physics 1985;11(11):2011-20.
1985: R L Siddon; Lynda Chin
Two-film brachytherapy reconstruction algorithm.
Medical physics 1985;12(1):77-83.
1983: Lynda Chin; Peter Kijewski; G K Svensson; B E Bjärngard
Dose optimization with computer-controlled gantry rotation, collimator motion and dose-rate variation.
International journal of radiation oncology, biology, physics 1983;9(5):723-9.
1982: A B Wolbarst; Lynda Chin; G K Svensson
Optimization of radiation therapy: integral-response of a model biological system.
International journal of radiation oncology, biology, physics 1982;8(10):1761-9.
1982: R L Siddon; Lynda Chin; R E Zimmerman; J B Mendel; W D Kaplan
Utilization of parasternal lymphoscintigraphy in radiation therapy of breast carcinoma.
International journal of radiation oncology, biology, physics 1982;8(6):1059-63.
1981: Lynda Chin; Peter Kijewski; G K Svensson; J T Chaffey; M B Levene; B E Bjärngard
A computer-controlled radiation therapy machine for pelvic and para-aortic nodal areas.
International journal of radiation oncology, biology, physics 1981;7(1):61-70.