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Yick-Pang Ching

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Jia Xiao; Yick-Pang Ching; Man-Lung Fung; Emily C Liong; Amin A Nanji; George L Tipoe
Garlic-derived S-allylmercaptocysteine is a hepato-protective agent in non-alcoholic fatty liver disease in vivo animal model.
Ching-Ping Chan; Yick-Pang Ching; Kin-Hang Kok; Yeung-Tung Siu; Hei-Man Vincent Tang; Dong-Yan Jin
Group I p21-activated kinases facilitate Tax-mediated transcriptional activation of the human T-cell leukemia virus type 1 long terminal repeats.
Hei-Man Vincent Tang; Chi-Ming Wong; Kin-Hang Kok; Yeung-Tung Siu; Hiroshi Takemori; Ching-Ping Chan; Yick-Pang Ching; Wei-Wei Gao; Dong-Yan Jin
LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription.

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2013: Jia Xiao; Yick-Pang Ching; Man-Lung Fung; Emily C Liong; Amin A Nanji; George L Tipoe
Garlic-derived S-allylmercaptocysteine is a hepato-protective agent in non-alcoholic fatty liver disease in vivo animal model.
European journal of nutrition 2013;52(1):179-91.
2013: Ching-Ping Chan; Yick-Pang Ching; Kin-Hang Kok; Yeung-Tung Siu; Hei-Man Vincent Tang; Dong-Yan Jin
Group I p21-activated kinases facilitate Tax-mediated transcriptional activation of the human T-cell leukemia virus type 1 long terminal repeats.
Retrovirology 2013;10():47.
2013: Hei-Man Vincent Tang; Chi-Ming Wong; Kin-Hang Kok; Yeung-Tung Siu; Hiroshi Takemori; Ching-Ping Chan; Yick-Pang Ching; Wei-Wei Gao; Dong-Yan Jin
LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription.
Retrovirology 2013;10():40.
2012: Wai-Lung Lai; Joyce Man-Fong Lee; Veronica Yee-Law Leong; Irene Oi-Lin Ng; Leo Lap-Yan Wong; Yuan Zhou; Wing-Yan Hung; Dong-Yan Jin; Yick-Pang Ching
The centrosomal protein Tax1 binding protein 2 is a novel tumor suppressor in hepatocellular carcinoma regulated by cyclin-dependent kinase 2.
Hepatology (Baltimore, Md.) 2012;56(5):1770-81.
2012: Chi-Wai Lee; Joyce Man-Fong Lee; Veronica Yee-Law Leong; Heong-Fai Liu; Irene Oi-Lin Ng; Edith Yuk-Ting Tse; Leo Lap-Yan Wong; D Grahame Hardie; Yick-Pang Ching
AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells.
Cancer research 2012;72(17):4394-404.
2012: Jia Xiao; Yick-Pang Ching; Man-Lung Fung; Ming-Tat Ling; Emily C Liong; George L Tipoe
S-allylmercaptocysteine reduces carbon tetrachloride-induced hepatic oxidative stress and necroinflammation via nuclear factor kappa B-dependent pathways in mice.
European journal of nutrition 2012;51(3):323-33.
2012: Grace Wing-Yan Mak; Irene Oi-Lin Ng; Yuan Zhou; Wai-Lung Lai; Mingtao Li; Yick-Pang Ching
CDK5RAP3 is a novel repressor of p14ARF in hepatocellular carcinoma cells.
PloS one 2012;7(7):e42210.
2011: Yang Xu; Yuan Zhou; Feng Chen; Yick-Pang Ching; Jen-Fu Chiu; Qing-Yu He
Multiple pathways were involved in tubeimoside-1-induced cytotoxicity of HeLa cells.
Journal of proteomics 2011;75(2):491-501.
2011: Benson Wui-Man Lau; Tatia M C Lee; Siu-Wa Tang; Suk Yu Yau; Yick-Pang Ching; Kwok-Fai So
Effect of corticosterone and paroxetine on masculine mating behavior: possible involvement of neurogenesis.
The journal of sexual medicine 2011;8(5):1390-403.
2011: Sze Ue Luk; Wei Ney Yap; Yung-Tuen Chiu; Davy T W Lee; Stephanie Ma; Terence Kin Wah Lee; Raja S Vasireddy; Yong-Chuan Wong; Yick-Pang Ching; Colleen Nelson; Yee Leng Yap; Ming-Tat Ling
Gamma-tocotrienol as an effective agent in targeting prostate cancer stem cell-like population.
International journal of cancer. Journal international du cancer 2011;128(9):2182-91.
2011: Grace Wing-Yan Mak; Mandy Man-Lok Chan; Veronica Yee-Law Leong; Joyce Man-Fong Lee; Tai-On Yau; Irene Oi-Lin Ng; Yick-Pang Ching
Overexpression of a novel activator of PAK4, the CDK5 kinase-associated protein CDK5RAP3, promotes hepatocellular carcinoma metastasis.
Cancer research 2011;71(8):2949-58.
2011: Wen Deng; Sai Wah Tsao; G W Y Mak; C M Tsang; Yick-Pang Ching; Xin-Yuan Guan; Michael S Y Huen; Annie L M Cheung
Impact of G₂ checkpoint defect on centromeric instability.
Oncogene 2011;30(11):1281-9.
2011: Suk Yu Yau; Siu-Wa Tang; Jian-Bin Tong; Richard Wong; Yick-Pang Ching; Benson Wui-Man Lau; Tatia M C Lee; Guang Qiu; Kwok-Fai So
Hippocampal neurogenesis and dendritic plasticity support running-improved spatial learning and depression-like behaviour in stressed rats.
PloS one 2011;6(9):e24263.
2011: Kin Pong Tao; Kin Wang Chan; Yick-Pang Ching; Sze Wan Fong; Zhihong Lu; Siu Yuen Chan
TSPYL2 is important for G1 checkpoint maintenance upon DNA damage.
PloS one 2011;6(6):e21602.
2011: P Y Cheung; Y L Yip; Sai Wah Tsao; Yick-Pang Ching; A L M Cheung
Id-1 induces cell invasiveness in immortalized epithelial cells by regulating cadherin switching and Rho GTPases.
Journal of cellular biochemistry 2011;112(1):157-68.
2010: Thomas Ho-Yin Leung; Judy Wai Ping Yam; Lap-Ki Chan; Yick-Pang Ching; Irene Oi-Lin Ng
Deleted in liver cancer 2 suppresses cell growth via the regulation of the Raf-1-ERK1/2-p70S6K signalling pathway.
Liver international : official journal of the International Association for the Study of the Liver 2010;30(9):1315-23.
2010: Michael S Y Huen; Shirley M-H Sy; Ka Man Leung; Yick-Pang Ching; George L Tipoe; Cornelia Man; Shuo Dong; Junjie Chen
SON is a spliceosome-associated factor required for mitotic progression.
Cell cycle (Georgetown, Tex.) 2010;9(13):2679-85.
2010: Michael S Y Huen; Jun Huang; Justin W C Leung; Shirley M-H Sy; Ka Man Leung; Yick-Pang Ching; Sai Wah Tsao; Junjie Chen
Regulation of chromatin architecture by the PWWP domain-containing DNA damage-responsive factor EXPAND1/MUM1.
Molecular cell 2010;37(6):854-64.
2010: Ivan Chun-Fai Hui; Edmund Kwok-Kwan Tung; Karen Man-Fong Sze; Yick-Pang Ching; Irene Oi-Lin Ng
Rapamycin and CCI-779 inhibit the mammalian target of rapamycin signalling in hepatocellular carcinoma.
Liver international : official journal of the International Association for the Study of the Liver 2010;30(1):65-75.
2009: Chi Man Tsang; Echo Ping Woi Lau; Kaijun Di; Pak Yan Cheung; Pok Man Hau; Yick-Pang Ching; Yong Chuan Wong; Annie Lai Man Cheung; THOMAS WAN; Yao Tong; Sai Wah Tsao; Yibin Feng
Berberine inhibits Rho GTPases and cell migration at low doses but induces G2 arrest and apoptosis at high doses in human cancer cells.
International journal of molecular medicine 2009;24(1):131-8.
2009: Edmund Kwok-Kwan Tung; Chun-Ming Wong; Tai-On Yau; Joyce Man-Fong Lee; Yick-Pang Ching; Irene Oi-Lin Ng
HAI-2 is epigenetically downregulated in human hepatocellular carcinoma, and its Kunitz domain type 1 is critical for anti-invasive functions.
International journal of cancer. Journal international du cancer 2009;124(8):1811-9.
2009: Benson Wui-Man Lau; Suk Yu Yau; Tatia M C Lee; Yick-Pang Ching; Siu-Wa Tang; Kwok-Fai So
Intracerebroventricular infusion of cytosine-arabinoside causes prepulse inhibition disruption.
Neuroreport 2009;20(4):371-7.
2009: Tai-On Yau; Chi Fat Chan; S Gee-San Lam; O-F Cheung; Yick-Pang Ching; Dong-Yan Jin; Mai Har Sham; I O L Ng
Hepatocyte-specific activation of NF-kappaB does not aggravate chemical hepatocarcinogenesis in transgenic mice.
The Journal of pathology 2009;217(3):353-61.
2008: Karen Man-Fong Sze; Yick-Pang Ching; Dong-Yan Jin; Irene Oi-Lin Ng
Role of a novel splice variant of mitotic arrest deficient 1 (MAD1), MAD1beta, in mitotic checkpoint control in liver cancer.
Cancer research 2008;68(22):9194-201.
2008: Yeung-Tung Siu; Yick-Pang Ching; Dong-Yan Jin
Activation of TORC1 transcriptional coactivator through MEKK1-induced phosphorylation.
Molecular biology of the cell 2008;19(11):4750-61.
2008: Y Mei; Z Yuan; B Song; D Li; C Ma; C Hu; Yick-Pang Ching; M Li
Activating transcription factor 3 up-regulated by c-Jun NH(2)-terminal kinase/c-Jun contributes to apoptosis induced by potassium deprivation in cerebellar granule neurons.
Neuroscience 2008;151(3):771-9.
2008: Carmen Chak-Lui Wong; Chun-Ming Wong; Frankie Chi Fat Ko; Lo-Kong Chan; Yick-Pang Ching; Judy Wai Ping Yam; Irene Oi-Lin Ng
Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma.
PloS one 2008;3(7):e2779.
2007: Chi Ma; Chunyi Ying; Zhongmin Yuan; Bin Song; Dan Li; Yulin Liu; Bingquan Lai; Wenming Li; Ruzhu Chen; Yick-Pang Ching; Mingtao Li
dp5/HRK is a c-Jun target gene and required for apoptosis induced by potassium deprivation in cerebellar granule neurons.
The Journal of biological chemistry 2007;282(42):30901-9.
2007: Zhongmin Yuan; Yuping Mei; Jing Zhou; Minghui Tan; Bin Song; Chi Ma; Chunyi Ying; Dan Li; Yick-Pang Ching; Mingtao Li
E2F1 is not essential for apoptosis induced by potassium deprivation in cerebellar granule neurons.
Neuroscience letters 2007;424(3):155-9.
2007: Kin-Hang Kok; Ming-Him James Ng; Yick-Pang Ching; Dong-Yan Jin
Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA.
The Journal of biological chemistry 2007;282(24):17649-57.
2007: Hongyan Li; King-Leung Fung; Dong-Yan Jin; Stephen S M Chung; Yick-Pang Ching; Irene Oi-Lin Ng; Kong Hung SZE; Ben C B Ko; Hongzhe Sun
Solution structures, dynamics, and lipid-binding of the sterile alpha-motif domain of the deleted in liver cancer 2.
Proteins 2007;67(4):1154-66.
2007: Chun-Ming Wong; Yeung-Lam Ng; Joyce Man-Fong Lee; Carmen Chak-Lui Wong; Oi-Fung Cheung; Chung-Yiu Chan; Edmund Kwok-Kwan Tung; Yick-Pang Ching; Irene Oi-Lin Ng
Tissue factor pathway inhibitor-2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma.
Hepatology (Baltimore, Md.) 2007;45(5):1129-38.
2007: Yick-Pang Ching; Veronica Y L Leong; Man-Fong Lee; Hai-Tao Xu; Dong-Yan Jin; Irene Oi-Lin Ng
P21-activated protein kinase is overexpressed in hepatocellular carcinoma and enhances cancer metastasis involving c-Jun NH2-terminal kinase activation and paxillin phosphorylation.
Cancer research 2007;67(8):3601-8.
2007: King-Tung Chin; Abel C S Chun; Yick-Pang Ching; Kuan-Teh Jeang; Dong-Yan Jin
Human T-cell leukemia virus oncoprotein tax represses nuclear receptor-dependent transcription by targeting coactivator TAX1BP1.
Cancer research 2007;67(3):1072-81.
2007: King-Tung Chin; Hai-Tao Xu; Yick-Pang Ching; Dong-Yan Jin
Differential subcellular localization and activity of kelch repeat proteins KLHDC1 and KLHDC2.
Molecular and cellular biochemistry 2007;296(1-2):109-19.
2006: David W Chan; Chung-Yiu Chan; Judy Wai Ping Yam; Yick-Pang Ching; Irene Oi-Lin Ng
Prickle-1 negatively regulates Wnt/beta-catenin pathway by promoting Dishevelled ubiquitination/degradation in liver cancer.
Gastroenterology 2006;131(4):1218-27.
2006: Yick-Pang Ching; Shing-Fai Chan; Kuan-Teh Jeang; Dong-Yan Jin
The retroviral oncoprotein Tax targets the coiled-coil centrosomal protein TAX1BP2 to induce centrosome overduplication.
Nature cell biology 2006;8(7):717-24.
2006: David Chi-Heng Ng; Shing-Fai Chan; Kin-Hang Kok; Judy Wai Ping Yam; Yick-Pang Ching; Irene Oi-Lin Ng; Dong-Yan Jin
Mitochondrial targeting of growth suppressor protein DLC2 through the START domain.
FEBS letters 2006;580(1):191-8.
2006: Xiao Ming Fan; Xiao Hua Jiang; Qing Gu; Yick-Pang Ching; Hua He; Harry Hua-Xiang Xia; Marie Chia Mi Lin; Annie On-On Chan; Man-Fung Yuen; Hsiang-Fu Kung; Benjamin Chun-Yu Wong
Inhibition of Akt/PKB by a COX-2 inhibitor induces apoptosis in gastric cancer cells.
Digestion 2006;73(2-3):75-83.
2005: Thomas Ho-Yin Leung; Yick-Pang Ching; Judy Wai Ping Yam; Chun-Ming Wong; Tai-On Yau; Dong-Yan Jin; Irene Oi-Lin Ng
Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(42):15207-12.
2005: Chun-Ming Wong; Judy Wai Ping Yam; Yick-Pang Ching; Tai-On Yau; Thomas Ho-Yin Leung; Dong-Yan Jin; Irene Oi-Lin Ng
Rho GTPase-activating protein deleted in liver cancer suppresses cell proliferation and invasion in hepatocellular carcinoma.
Cancer research 2005;65(19):8861-8.
2005: Hiu Wing Cheung; Yick-Pang Ching; John M Nicholls; Ming-Tat Ling; Yong-Chuan Wong; Nick Hui; Annie Cheung; Sai Wah Tsao; Qi Wang; P W Yeun; Kwok-Wai Lo; Dong-Yan Jin; Xianghong Wang
Epigenetic inactivation of CHFR in nasopharyngeal carcinoma through promoter methylation.
Molecular carcinogenesis 2005;43(4):237-45.
2004: Karen Man-Fong Sze; Yick-Pang Ching; Dong-Yan Jin; Irene Oi-Lin Ng
Association of MAD2 expression with mitotic checkpoint competence in hepatoma cells.
Journal of biomedical science 2004;11(6):920-7.
2004: Robert Z Qi; Yick-Pang Ching; Hsiang-Fu Kung; Jerry H Wang
Alpha-chimaerin exists in a functional complex with the Cdk5 kinase in brain.
FEBS letters 2004;561(1-3):177-80.
2004: Yick-Pang Ching; Abel C S Chun; King-Tung Chin; Zhi-Qing Zhang; Kuan-Teh Jeang; Dong-Yan Jin
Specific TATAA and bZIP requirements suggest that HTLV-I Tax has transcriptional activity subsequent to the assembly of an initiation complex.
Retrovirology 2004;1():18.
2003: Chun-Ming Wong; Joyce Man-Fong Lee; Yick-Pang Ching; Dong-Yan Jin; Irene Oi-Lin Ng
Genetic and epigenetic alterations of DLC-1 gene in hepatocellular carcinoma.
Cancer research 2003;63(22):7646-51.
2003: Yick-Pang Ching; Veronica Y L Leong; Chi-Ming Wong; Hsiang-Fu Kung
Identification of an autoinhibitory domain of p21-activated protein kinase 5.
The Journal of biological chemistry 2003;278(36):33621-4.
2003: Yuan Zhou; Yick-Pang Ching; Raymond W M Ng; Dong-Yan Jin
Differential expression, localization and activity of two alternatively spliced isoforms of human APC regulator CDH1.
The Biochemical journal 2003;374(Pt 2):349-58.
2003: Yuan Zhou; Yick-Pang Ching; Abel C S Chun; Dong-Yan Jin
Nuclear localization of the cell cycle regulator CDH1 and its regulation by phosphorylation.
The Journal of biological chemistry 2003;278(14):12530-6.
2003: Yick-Pang Ching; Chun-Ming Wong; Shing-Fai Chan; Thomas Ho-Yin Leung; David Chi-Heng Ng; Dong-Yan Jin; Irene Oi-Lin Ng
Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma.
The Journal of biological chemistry 2003;278(12):10824-30.
2003: Chi-Ming Wong; Yick-Pang Ching; Yuan Zhou; Hsiang-Fu Kung; Dong-Yan Jin
Transcriptional regulation of yeast peroxiredoxin gene TSA2 through Hap1p, Rox1p, and Hap2/3/5p.
Free radical biology & medicine 2003;34(5):585-97.
2002: Yuan Zhou; Yick-Pang Ching; Raymond W M Ng; Dong-Yan Jin
The APC regulator CDH1 is essential for the progression of embryonic cell cycles in Xenopus.
Biochemical and biophysical research communications 2002;294(1):120-6.
2002: Yick-Pang Ching; Andy S H Pang; Wing-Ho Lam; Robert Z Qi; Jerry H Wang
Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor.
The Journal of biological chemistry 2002;277(18):15237-40.
2002: Yuan Zhou; Yick-Pang Ching; Kin-Hang Kok; Hsiang-Fu Kung; Dong-Yan Jin
Post-transcriptional suppression of gene expression in Xenopus embryos by small interfering RNA.
Nucleic acids research 2002;30(7):1664-9.
2002: Yick-Pang Ching; Hai-Jun Zhou; Jian-gang Yuan; Boqin Qiang; Hsiang-fu Kung Hf; Dong-Yan Jin
Identification and characterization of FTSJ2, a novel human nucleolar protein homologous to bacterial ribosomal RNA methyltransferase.
Genomics 2002;79(1):2-6.
2000: X Wang; Yick-Pang Ching; W H Lam; Z Qi; Mingjie Zhang; Jerry H Wang
Identification of a common protein association region in the neuronal Cdk5 activator.
The Journal of biological chemistry 2000;275(41):31763-9.
2000: Yick-Pang Ching; Z Qi; J H Wang
Cloning of three novel neuronal Cdk5 activator binding proteins.
Gene 2000;242(1-2):285-94.