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Antonio Chiocca

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Kaur Balveen; Cripe Timothy P; Chiocca E Antonio
"Buy one get one free": armed viruses for the treatment of cancer cells and their microenvironment.
Kim Yangjin; Lawler Sean; Nowicki Michal O; Chiocca E Antonio; Friedman Avner
A mathematical model for pattern formation of glioma cells outside the tumor spheroid core.
Peruzzi Pier Paolo; Lawler Sean E; Senior Steve L; Dmitrieva Nina; Edser Pauline A H; Gianni Davide; Chiocca E Antonio; Wade-Martins Richard
Physiological transgene regulation and functional complementation of a neurological disease gene deficiency in neurons.

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All Publications

2009: Kaur Balveen; Cripe Timothy P; Chiocca E Antonio
"Buy one get one free": armed viruses for the treatment of cancer cells and their microenvironment.
Current gene therapy 2009;9(5):341-55.
2009: Kim Yangjin; Lawler Sean; Nowicki Michal O; Chiocca E Antonio; Friedman Avner
A mathematical model for pattern formation of glioma cells outside the tumor spheroid core.
Journal of theoretical biology 2009;260(3):359-71.
2009: Peruzzi Pier Paolo; Lawler Sean E; Senior Steve L; Dmitrieva Nina; Edser Pauline A H; Gianni Davide; Chiocca E Antonio; Wade-Martins Richard
Physiological transgene regulation and functional complementation of a neurological disease gene deficiency in neurons.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(9):1517-26.
2009: Elsheikh Bakri; Kissel John T; Christoforidis Gregory; Wicklund Matthew; Kehagias Dimitri T; Chiocca E Antonio; Mendell Jerry R
Spinal angiography and epidural venography in juvenile muscular atrophy of the distal arm "Hirayama disease".
Muscle & nerve 2009;40(2):206-12.
2009: Peruzzi Pierpaolo; Ray-Chaudhuri Abhik; Slone Wayne H; Mekhjian Hagop S; Porcu Pierluigi; Chiocca E Antonio
Reversal of neurological deficit after chemotherapy in BCL-6-positive neurolymphomatosis. Case report.
Journal of neurosurgery 2009;111(2):247-51.
2009: Hirschl Robert A; Wilson Jeff; Miller Brandon; Bergese Sergio; Chiocca E Antonio
The predictive value of low-field strength magnetic resonance imaging for intraoperative residual tumor detection. Clinical article.
Journal of neurosurgery 2009;111(2):252-7.
2009: Asadi-Moghaddam Kaveh; Chiocca E Antonio
Gene- and viral-based therapies for brain tumors.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2009;6(3):547-57.
2009: Alvarez-Breckenridge Christopher; Kaur Balveen; Chiocca E Antonio
Pharmacologic and chemical adjuvants in tumor virotherapy.
Chemical reviews 2009;109(7):3125-40.
2009: Patel Tanmay R; Chiocca E Antonio; Freimer Miriam L; Christoforidis Gregory A
Lack of epidural pressure change with neck flexion in a patient with Hirayama disease: case report.
Neurosurgery 2009;64(6):E1196-7; discussion E1197.
2009: Lawler Sean; Chiocca E Antonio
Emerging functions of microRNAs in glioblastoma.
Journal of neuro-oncology 2009;92(3):297-306.
2009: Grandi Paola; Peruzzi Pierpaolo; Reinhart Bonnie; Cohen Justus B; Chiocca E Antonio; Glorioso Joseph C
Design and application of oncolytic HSV vectors for glioblastoma therapy.
Expert review of neurotherapeutics 2009;9(4):505-17.
2009: Suzuki Masataka; Kasai Kazue; Ohtsuki Akihiro; Godlewski Jakub; Nowicki Michal O; Chiocca E Antonio; Saeki Yoshinaga
ICP0 inhibits the decrease of HSV amplicon-mediated transgene expression.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(4):707-15.
2009: Tian Jianjun Paul; Friedman Avner; Wang Jin; Chiocca E Antonio
Modeling the effects of resection, radiation and chemotherapy in glioblastoma.
Journal of neuro-oncology 2009;91(3):287-93.
2009: Aghi Manish K; Chiocca E Antonio
Phase ib trial of oncolytic herpes virus G207 shows safety of multiple injections and documents viral replication.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(1):8-9.
2009: Tanaka Shigeru; Shaikh Imran Mohammed; Chiocca E Antonio; Saeki Yoshinaga
The Gs-linked receptor GPR3 inhibits the proliferation of cerebellar granule cells during postnatal development.
PloS one 2009;4(6):e5922.
2008: Godlewski Jakub; Nowicki Michal O; Bronisz Agnieszka; Williams Shanté; Otsuki Akihiro; Nuovo Gerard; Raychaudhury Abhik; Newton Herbert B; Chiocca E Antonio; Lawler Sean
Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal.
Cancer research 2008;68(22):9125-30.
2008: Suzuki Masataka; Chiocca E Antonio; Saeki Yoshinaga
Stable transgene expression from HSV amplicon vectors in the brain: potential involvement of immunoregulatory signals.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(10):1727-36.
2008: Nowicki Michal O; Dmitrieva Nina; Stein Andrew M; Cutter Jennifer L; Godlewski Jakub; Saeki Yoshinaga; Nita Masayuki; Berens Michael E; Sander Leonard M; Newton Herbert B; Chiocca E Antonio; Lawler Sean
Lithium inhibits invasion of glioma cells; possible involvement of glycogen synthase kinase-3.
Neuro-oncology 2008;10(5):690-9.
2008: Otsuki Akihiro; Patel Ankita; Kasai Kazue; Suzuki Masataka; Kurozumi Kazuhiko; Chiocca E Antonio; Saeki Yoshinaga
Histone deacetylase inhibitors augment antitumor efficacy of herpes-based oncolytic viruses.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(9):1546-55.
2008: Kurozumi Kazuhiko; Hardcastle Jayson; Thakur Roopa; Shroll Joshua; Nowicki Michal; Otsuki Akihiro; Chiocca E Antonio; Kaur Balveen
Oncolytic HSV-1 infection of tumors induces angiogenesis and upregulates CYR61.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(8):1382-91.
2008: Aghi M; Visted T; Depinho R A; Chiocca E A
Oncolytic herpes virus with defective ICP6 specifically replicates in quiescent cells with homozygous genetic mutations in p16.
Oncogene 2008;27(30):4249-54.
2008: Kefas Benjamin; Godlewski Jakub; Comeau Laurey; Li Yunqing; Abounader Roger; Hawkinson Michael; Lee Jeongwu; Fine Howard; Chiocca E Antonio; Lawler Sean; Purow Benjamin
microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma.
Cancer research 2008;68(10):3566-72.
2008: Currier Mark A; Gillespie Rebecca A; Sawtell Nancy M; Mahller Yonatan Y; Stroup Greg; Collins Margaret H; Kambara Hirokazu; Chiocca E Antonio; Cripe Timothy P
Efficacy and safety of the oncolytic herpes simplex virus rRp450 alone and combined with cyclophosphamide.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(5):879-85.
2008: Chiocca E Antonio
Being old is no fun: treatment of glioblastoma multiforme in the elderly.
Journal of neurosurgery 2008;108(4):639-40.
2008: Pillai Promod; Ray-Chaudhury Abhik; Ammirati Mario; Chiocca E Antonio
Solitary pituitary sarcoidosis with normal endocrine function: case report.
Journal of neurosurgery 2008;108(3):591-4.
2008: Chiocca E Antonio; Smith Katie M; McKinney Byron; Palmer Cheryl A; Rosenfeld Steven; Lillehei Kevin; Hamilton Allan; DeMasters Betty K; Judy Kevin; Kirn David
A phase I trial of Ad.hIFN-beta gene therapy for glioma.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(3):618-26.
2008: Chiocca E Antonio
The host response to cancer virotherapy.
Current opinion in molecular therapeutics 2008;10(1):38-45.
2007: Kurozumi Kazuhiko; Hardcastle Jayson; Thakur Roopa; Yang Ming; Christoforidis Gregory; Fulci Giulia; Hochberg Fred H; Weissleder Ralph; Carson William; Chiocca E Antonio; Kaur Balveen
Effect of tumor microenvironment modulation on the efficacy of oncolytic virus therapy.
Journal of the National Cancer Institute 2007;99(23):1768-81.
2007: Dang David; Baig Mirza N; Christoforidis Greg; Chiocca E Antonio; Gabriel Joshue
C2/C3 pathologic fractures from polyostotic fibrous dysplasia of the cervical spine treated with percutaneous vertebroplasty.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2007;16 Suppl 3():250-4.
2007: Suzuki Masataka; Chiocca E Antonio; Saeki Yoshinaga
Early STAT1 activation after systemic delivery of HSV amplicon vectors suppresses transcription of the vector-encoded transgene.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(11):2017-26.
2007: Fulci Giulia; Dmitrieva Nina; Gianni Davide; Fontana Elisabeth J; Pan Xiaogang; Lu Yanhui; Kaufman Claire S; Kaur Balveen; Lawler Sean E; Lee Robert J; Marsh Clay B; Brat Daniel J; van Rooijen Nico; Stemmer-Rachamimov Anat O; Hochberg Fred H; Weissleder Ralph; Martuza Robert L; Chiocca E Antonio
Depletion of peripheral macrophages and brain microglia increases brain tumor titers of oncolytic viruses.
Cancer research 2007;67(19):9398-406.
2007: Stein Andrew M; Nowicki Michal O; Demuth Tim; Berens Michael E; Lawler Sean E; Chiocca E Antonio; Sander Leonard M
Estimating the cell density and invasive radius of three-dimensional glioblastoma tumor spheroids grown in vitro.
Applied optics 2007;46(22):5110-8.
2007: Chiocca E Antonio; Schwartzbaum Judith A
Gliomas and venous thromboembolism: how common?
Journal of neurosurgery 2007;106(4):599-600; discussion 600.
2007: Chang Susan; Vogelbaum Michael; Lang Frederick F; Haines Stephen; Kunwar Sandeep; Chiocca E Antonio; Olivi Alessandro; Quinones-Hinojosa Alfredo; Parsa Andrew; Warnick Ronald;
GNOSIS: guidelines for neuro-oncology: standards for investigational studies--reporting of surgically based therapeutic clinical trials.
Journal of neuro-oncology 2007;82(2):211-20.
2007: Ishizuka Kelly; Oaklander Anne Louise; Chiocca E Antonio
A retrospective analysis of reasons for reoperation following initially successful peripheral nerve stimulation.
Journal of neurosurgery 2007;106(3):388-90.
2007: Hardcastle Jayson; Kurozumi Kazuhiko; Chiocca E Antonio; Kaur Balveen
Oncolytic viruses driven by tumor-specific promoters.
Current cancer drug targets 2007;7(2):181-9.
2007: Fulci Giulia; Chiocca E Antonio
The status of gene therapy for brain tumors.
Expert opinion on biological therapy 2007;7(2):197-208.
2007: Kaur Balveen; Chiocca E Antonio
Personalizing oncolytic virotherapy?
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(1):6-7.
2006: Kaur Balveen; Chiocca E Antonio
Oncolytic viruses: extreme treatment for an extreme disease.
Future microbiology 2006;1():351-3.
2006: Lamfers Martine L M; Fulci Giulia; Gianni Davide; Tang Yi; Kurozumi Kazuhiko; Kaur Balveen; Moeniralm Sharif; Saeki Yoshinaga; Carette Jan E; Weissleder Ralph; Vandertop W Peter; van Beusechem Victor W; Dirven Clemens M F; Chiocca E Antonio
Cyclophosphamide increases transgene expression mediated by an oncolytic adenovirus in glioma-bearing mice monitored by bioluminescence imaging.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;14(6):779-88.
2006: Yamamoto S; Deckter L A; Kasai K; Chiocca E A; Saeki Y
Imaging immediate-early and strict-late promoter activity during oncolytic herpes simplex virus type 1 infection and replication in tumors.
Gene therapy 2006;13(24):1731-6.
2006: Aghi Manish; Cohen Kenneth S; Klein Rachael J; Scadden David T; Chiocca E Antonio
Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes.
Cancer research 2006;66(18):9054-64.
2006: Sarkar Atom; Chiocca E Antonio
Prognostic indicators.
Journal of neurosurgery 2006;105(2):161-2; discussion 162.
2006: Fulci Giulia; Breymann Laura; Gianni Davide; Kurozomi Kazuhiko; Rhee Sarah S; Yu Jianhua; Kaur Balveen; Louis David N; Weissleder Ralph; Caligiuri Michael A; Chiocca E Antonio
Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(34):12873-8.
2006: Cutter Jennifer L; Kurozumi Kazuhiko; Chiocca E Antonio; Kaur Balveen
Gene therapeutics: the future of brain tumor therapy?
Expert review of anticancer therapy 2006;6(7):1053-64.
2006: Thoman W James; Ammirati Mario; Caragine Louis P; McGregor John M; Sarkar Atom; Chiocca E Antonio
Brain tumor imaging and surgical management: the neurosurgeon's perspective.
Topics in magnetic resonance imaging : TMRI 2006;17(2):121-6.
2006: Terada K; Wakimoto H; Tyminski E; Chiocca E A; Saeki Y
Development of a rapid method to generate multiple oncolytic HSV vectors and their in vivo evaluation using syngeneic mouse tumor models.
Gene therapy 2006;13(8):705-14.
2006: Lawler S E; Peruzzi P P; Chiocca E A
Genetic strategies for brain tumor therapy.
Cancer gene therapy 2006;13(3):225-33.
2006: Friedman Avner; Tian Jianjun Paul; Fulci Giulia; Chiocca E Antonio; Wang Jin
Glioma virotherapy: effects of innate immune suppression and increased viral replication capacity.
Cancer research 2006;66(4):2314-9.
2006: Aghi Manish; Chiocca E Antonio
Gene therapy for glioblastoma.
Neurosurgical focus 2006;20(4):E18.
2005: Kambara Hirokazu; Saeki Yoshinaga; Chiocca E Antonio
Cyclophosphamide allows for in vivo dose reduction of a potent oncolytic virus.
Cancer research 2005;65(24):11255-8.
2005: Aghi Manish; Chiocca E Antonio
Contribution of bone marrow-derived cells to blood vessels in ischemic tissues and tumors.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(6):994-1005.
2005: Lamfers Martine L M; Gianni Davide; Tung Ching-Hsuan; Idema Sander; Schagen Frederik H E; Carette Jan E; Quax Paul H A; Van Beusechem Victor W; Vandertop W Peter; Dirven Clemens M F; Chiocca E Antonio; Gerritsen Winald R
Tissue inhibitor of metalloproteinase-3 expression from an oncolytic adenovirus inhibits matrix metalloproteinase activity in vivo without affecting antitumor efficacy in malignant glioma.
Cancer research 2005;65(20):9398-405.
2005: Tyminski Edyta; Leroy Stanley; Terada Kinya; Finkelstein Dianne M; Hyatt Janice L; Danks Mary K; Potter Philip M; Saeki Yoshinaga; Chiocca E Antonio
Brain tumor oncolysis with replication-conditional herpes simplex virus type 1 expressing the prodrug-activating genes, CYP2B1 and secreted human intestinal carboxylesterase, in combination with cyclophosphamide and irinotecan.
Cancer research 2005;65(15):6850-7.
2005: Kambara Hirokazu; Okano Hideyuki; Chiocca E Antonio; Saeki Yoshinaga
An oncolytic HSV-1 mutant expressing ICP34.5 under control of a nestin promoter increases survival of animals even when symptomatic from a brain tumor.
Cancer research 2005;65(7):2832-9.
2004: Chiocca E Antonio; Abbed Khalid M; Tatter Stephen; Louis David N; Hochberg Fred H; Barker Fred; Kracher Jean; Grossman Stuart A; Fisher Joy D; Carson Kathryn; Rosenblum Mark; Mikkelsen Tom; Olson Jeff; Markert James; Rosenfeld Steven; Nabors L Burt; Brem Steven; Phuphanich Surasak; Freeman Scott; Kaplan Rick; Zwiebel James
A phase I open-label, dose-escalation, multi-institutional trial of injection with an E1B-Attenuated adenovirus, ONYX-015, into the peritumoral region of recurrent malignant gliomas, in the adjuvant setting.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;10(5):958-66.
2004: Chiocca E Antonio; Broaddus William C; Gillies George T; Visted Therese; Lamfers Martine L M
Neurosurgical delivery of chemotherapeutics, targeted toxins, genetic and viral therapies in neuro-oncology.
Journal of neuro-oncology 2004;69(1-3):101-17.
2004: Ichikawa Tomotsugu; Terada Kinya; Tamiya Takashi; Basilion James P; Chiocca E Antonio; Date Isao
[Molecular imaging of transgene expression in brain tumors]
No shinkei geka. Neurological surgery 2004;32(8):805-24.
2004: Inoue R; Moghaddam K A; Ranasinghe M; Saeki Y; Chiocca E A; Wade-Martins R
Infectious delivery of the 132 kb CDKN2A/CDKN2B genomic DNA region results in correctly spliced gene expression and growth suppression in glioma cells.
Gene therapy 2004;11(15):1195-204.
2004: Nestler Ulf; Wakimoto Hiroaki; Siller-Lopez Fernando; Aguilar Laura K; Chakravarti Arnab; Muzikansky Alona; Stemmer-Rachamimov Anat; Chiocca E Antonio; Aguilar-Cordova Estuardo; Hochberg Fred H
The combination of adenoviral HSV TK gene therapy and radiation is effective in athymic mouse glioblastoma xenografts without increasing toxic side effects.
Journal of neuro-oncology 2004;67(1-2):177-88.
2004: Post Dawn E; Fulci Giulia; Chiocca E Antonio; Van Meir Erwin G
Replicative oncolytic herpes simplex viruses in combination cancer therapies.
Current gene therapy 2004;4(1):41-51.
2004: Lev Michael H; Ozsunar Yelda; Henson John W; Rasheed Amjad A; Barest Glenn D; Harsh Griffith R; Fitzek Markus M; Chiocca E Antonio; Rabinov James D; Csavoy Andrew N; Rosen Bruce R; Hochberg Fred H; Schaefer Pamela W; Gonzalez R Gilberto
Glial tumor grading and outcome prediction using dynamic spin-echo MR susceptibility mapping compared with conventional contrast-enhanced MR: confounding effect of elevated rCBV of oligodendrogliomas [corrected].
AJNR. American journal of neuroradiology 2004;25(2):214-21.
2004: Wakimoto H; Fulci G; Tyminski E; Chiocca E Antonio
Altered expression of antiviral cytokine mRNAs associated with cyclophosphamide's enhancement of viral oncolysis.
Gene therapy 2004;11(2):214-23.
2004: Chiocca E Antonio; Waxman David J
Cytochrome p450-based gene therapies for cancer.
Methods in molecular medicine 2004;90():203-22.
2003: Chiocca E Antonio
Gene therapy: a primer for neurosurgeons.
Neurosurgery 2003;53(2):364-73; discussion 373.
2003: Kubo Shuji; Saeki Yoshinaga; Chiocca E Antonio; Mitani Kohnosuke
An HSV amplicon-based helper system for helper-dependent adenoviral vectors.
Biochemical and biophysical research communications 2003;307(4):826-30.
2003: Deisboeck T S; Wakimoto H; Nestler U; Louis D N; Sehgal P K; Simon M; Chiocca E A; Hochberg F H
Development of a novel non-human primate model for preclinical gene vector safety studies. Determining the effects of intracerebral HSV-1 inoculation in the common marmoset: a comparative study.
Gene therapy 2003;10(15):1225-33.
2003: Packard Scott D; Mandeville Joseph B; Ichikawa Tomotsugu; Ikeda Keiro; Terada Kinya; Niloff Stephanie; Chiocca E Antonio; Rosen Bruce R; Marota John J A
Functional response of tumor vasculature to PaCO2: determination of total and microvascular blood volume by MRI.
Neoplasia (New York, N.Y.) 2003;5(4):330-8.
2003: Wakimoto H; Johnson P R; Knipe D M; Chiocca E A
Effects of innate immunity on herpes simplex virus and its ability to kill tumor cells.
Gene therapy 2003;10(11):983-90.
2003: Chiocca E Antonio; Aghi Manish; Fulci Giulia
Viral therapy for glioblastoma.
Cancer journal (Sudbury, Mass.) 2003;9(3):167-79.
2003: Hampl Jürgen A; Camp Sara M; Mydlarz Wojciech K; Hampl Monika; Ichikawa Tomotsuga; Chiocca E Antonio; Louis David N; Sena-Esteves Miguel; Breakefield Xandra O
Potentiated gene delivery to tumors using herpes simplex virus/Epstein-Barr virus/RV tribrid amplicon vectors.
Human gene therapy 2003;14(7):611-26.
2003: Abe Tatsuya; Terada Kinya; Wakimoto Hiroaki; Inoue Ryo; Tyminski Edyta; Bookstein Robert; Basilion James P; Chiocca E Antonio
PTEN decreases in vivo vascularization of experimental gliomas in spite of proangiogenic stimuli.
Cancer research 2003;63(9):2300-5.
2003: Wade-Martins Richard; Saeki Yoshinaga; Chiocca E Antonio
Infectious delivery of a 135-kb LDLR genomic locus leads to regulated complementation of low-density lipoprotein receptor deficiency in human cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;7(5 Pt 1):604-12.
2003: Fulci Giulia; Chiocca Ennio Antonio
Oncolytic viruses for the therapy of brain tumors and other solid malignancies: a review.
Frontiers in bioscience : a journal and virtual library 2003;8():e346-60.
2003: Aghi Manish; Chiocca E A
Genetically engineered herpes simplex viral vectors in the treatment of brain tumors: a review.
Cancer investigation 2003;21(2):278-92.
2003: Saeki Yoshinaga; Breakefield Xandra O; Chiocca E Antonio
Improved HSV-1 amplicon packaging system using ICP27-deleted, oversized HSV-1 BAC DNA.
Methods in molecular medicine 2003;76():51-60.
2002: Rabinov James D; Lee Patricia Lani; Barker Frederick G; Louis David N; Harsh Griffith R; Cosgrove G Rees; Chiocca E Antonio; Thornton Allan F; Loeffler Jay S; Henson John W; Gonzalez R Gilberto
In vivo 3-T MR spectroscopy in the distinction of recurrent glioma versus radiation effects: initial experience.
Radiology 2002;225(3):871-9.
2002: Chiocca E Antonio
Oncolytic viruses.
Nature reviews. Cancer 2002;2(12):938-50.
2002: Ichikawa Tomotsugu; Högemann Dagmar; Saeki Yoshinaga; Tyminski Edyta; Terada Kinya; Weissleder Ralph; Chiocca E Antonio; Basilion James P
MRI of transgene expression: correlation to therapeutic gene expression.
Neoplasia (New York, N.Y.) 2002;4(6):523-30.
2002: Pawlik Timothy M; Nakamura Hideo; Mullen John T; Kasuya Hideki; Yoon Sam S; Chandrasekhar Soundararajalu; Chiocca E Antonio; Tanabe Kenneth K
Prodrug bioactivation and oncolysis of diffuse liver metastases by a herpes simplex virus 1 mutant that expresses the CYP2B1 transgene.
Cancer 2002;95(5):1171-81.
2002: Nakamura Hideo; Kasuya Hideki; Mullen John T; Yoon Sam S; Pawlik Timothy M; Chandrasekhar Soundararajalu; Donahue James M; Chiocca E Antonio; Chung Richard Y; Tanabe Kenneth K
Regulation of herpes simplex virus gamma(1)34.5 expression and oncolysis of diffuse liver metastases by Myb34.5.
The Journal of clinical investigation 2002;109(7):871-82.
2002: Abe Tatsuya; Wakimoto Hiroaki; Bookstein Robert; Maneval Daniel C; Chiocca E Antonio; Basilion James P
Intra-arterial delivery of p53-containing adenoviral vector into experimental brain tumors.
Cancer gene therapy 2002;9(3):228-35.
2002: Chiocca E Antonio
Guided genes for tumor warfare.
Nature biotechnology 2002;20(3):235-6.
2002: Wakimoto Hiroaki; Ikeda Keiro; Abe Tatsuya; Ichikawa Tomotsugu; Hochberg Fred H; Ezekowitz R Alan B; Pasternack Mark S; Chiocca E Antonio
The complement response against an oncolytic virus is species-specific in its activation pathways.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(3):275-82.
2002: Smith Edward R; Ott Mark; Wain John; Louis David N; Chiocca E Antonio
Massive growth of a meningioma into the brachial plexus and thoracic cavity after intraspinal and supraclavicular resection. Case report and review of the literature.
Journal of neurosurgery 2002;96(1 Suppl):107-11.
2001: Wade-Martins R; Smith E R; Tyminski E; Chiocca E A; Saeki Y
An infectious transfer and expression system for genomic DNA loci in human and mouse cells.
Nature biotechnology 2001;19(11):1067-70.
2001: Ichikawa T; Chiocca E A
Comparative analyses of transgene delivery and expression in tumors inoculated with a replication-conditional or -defective viral vector.
Cancer research 2001;61(14):5336-9.
2001: Saeki Y; Fraefel C; Ichikawa T; Breakefield X O; Chiocca E A
Improved helper virus-free packaging system for HSV amplicon vectors using an ICP27-deleted, oversized HSV-1 DNA in a bacterial artificial chromosome.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;3(4):591-601.
2001: Jacobs A; Tjuvajev J G; Dubrovin M; Akhurst T; Balatoni J; Beattie B; Joshi R; Finn R; Larson S M; Herrlinger U; Pechan P A; Chiocca E A; Breakefield X O; Blasberg R G
Positron emission tomography-based imaging of transgene expression mediated by replication-conditional, oncolytic herpes simplex virus type 1 mutant vectors in vivo.
Cancer research 2001;61(7):2983-95.
2001: Ichikawa T; Petros W P; Ludeman S M; Fangmeier J; Hochberg F H; Colvin O M; Chiocca E A
Intraneoplastic polymer-based delivery of cyclophosphamide for intratumoral bioconversion by a replicating oncolytic viral vector.
Cancer research 2001;61(3):864-8.
2000: Misdraji J; Ino Y; Louis D N; Rosenberg A E; Chiocca E A; Harris N L
Primary lymphoma of peripheral nerve: report of four cases.
The American journal of surgical pathology 2000;24(9):1257-65.
2000: Pawlik T M; Nakamura H; Yoon S S; Mullen J T; Chandrasekhar S; Chiocca E A; Tanabe K K
Oncolysis of diffuse hepatocellular carcinoma by intravascular administration of a replication-competent, genetically engineered herpesvirus.
Cancer research 2000;60(11):2790-5.
2000: Harsh G R; Deisboeck T S; Louis D N; Hilton J; Colvin M; Silver J S; Qureshi N H; Kracher J; Finkelstein D; Chiocca E A; Hochberg F H
Thymidine kinase activation of ganciclovir in recurrent malignant gliomas: a gene-marking and neuropathological study.
Journal of neurosurgery 2000;92(5):804-11.
2000: Ikeda K; Wakimoto H; Ichikawa T; Jhung S; Hochberg F H; Louis D N; Chiocca E A
Complement depletion facilitates the infection of multiple brain tumors by an intravascular, replication-conditional herpes simplex virus mutant.
Journal of virology 2000;74(10):4765-75.
2000: Qureshi N H; Bankiewicz K S; Louis D N; Hochberg F H; Chiocca E A; Harsh G R
Multicolumn infusion of gene therapy cells into human brain tumors: technical report.
Neurosurgery 2000;46(3):663-8; discussion 668-9.
2000: Weissleder R; Moore A; Mahmood U; Bhorade R; Benveniste H; Chiocca E A; Basilion J P
In vivo magnetic resonance imaging of transgene expression.
Nature medicine 2000;6(3):351-5.
2000: Smith E R; Chiocca E A
Oncolytic viruses as novel anticancer agents: turning one scourge against another.
Expert opinion on investigational drugs 2000;9(2):311-27.
2000: Yoon S S; Nakamura H; Carroll N M; Bode B P; Chiocca E A; Tanabe K K
An oncolytic herpes simplex virus type 1 selectively destroys diffuse liver metastases from colon carcinoma.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(2):301-11.
2000: Quiñones-Hinojosa A; Friedlander R M; Boyer P J; Batchelor T T; Chiocca E A
Solitary sciatic nerve lymphoma as an initial manifestation of diffuse neurolymphomatosis. Case report and review of the literature.
Journal of neurosurgery 2000;92(1):165-9.
1999: Sena-Esteves M; Saeki Y; Camp S M; Chiocca E A; Breakefield X O
Single-step conversion of cells to retrovirus vector producers with herpes simplex virus-Epstein-Barr virus hybrid amplicons.
Journal of virology 1999;73(12):10426-39.
1999: Chung R Y; Saeki Y; Chiocca E A
B-myb promoter retargeting of herpes simplex virus gamma34.5 gene-mediated virulence toward tumor and cycling cells.
Journal of virology 1999;73(9):7556-64.
1999: Aghi M; Chou T C; Suling K; Breakefield X O; Chiocca E A
Multimodal cancer treatment mediated by a replicating oncolytic virus that delivers the oxazaphosphorine/rat cytochrome P450 2B1 and ganciclovir/herpes simplex virus thymidine kinase gene therapies.
Cancer research 1999;59(16):3861-5.
1999: Ikeda K; Ichikawa T; Wakimoto H; Silver J S; Deisboeck T S; Finkelstein D; Harsh G R; Louis D N; Bartus R T; Hochberg F H; Chiocca E A
Oncolytic virus therapy of multiple tumors in the brain requires suppression of innate and elicited antiviral responses.
Nature medicine 1999;5(8):881-7.
1999: Ikeda K; Saeki Y; Gonzalez-Agosti C; Ramesh V; Chiocca E A
Inhibition of NF2-negative and NF2-positive primary human meningioma cell proliferation by overexpression of merlin due to vector-mediated gene transfer.
Journal of neurosurgery 1999;91(1):85-92.
1999: Yoon S S; Carroll N M; Chiocca E A; Tanabe K K
Influence of p53 on herpes simplex virus type 1 vectors for cancer gene therapy.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 1999;3(1):34-48.
1999: Barnett F H; Rainov N G; Ikeda K; Schuback D E; Elliott P; Kramm C M; Chase M; Qureshi N H; Harsh G; Chiocca E A; Breakefield X O
Selective delivery of herpes virus vectors to experimental brain tumors using RMP-7.
Cancer gene therapy 1999;6(1):14-20.
1999: Rainov N G; Ikeda K; Qureshi N H; Grover S; Herrlinger U; Pechan P; Chiocca E A; Breakefield X O; Barnett F H
Intraarterial delivery of adenovirus vectors and liposome-DNA complexes to experimental brain neoplasms.
Human gene therapy 1999;10(2):311-8.
1999: Qureshi N H; Chiocca E A
A review of gene therapy for the treatment of central nervous system tumors.
Critical reviews in oncogenesis 1999;10(4):261-74.
1999: Rainov N G; Ikeda K; Qureshi N; Grover S; Barnett F H; Herrlinger U; Quinones A; Chiocca E A; Breakefield X O
Intra-arterial virus and nonvirus vector-mediated gene transfer to experimental rat brain tumors.
Frontiers of radiation therapy and oncology 1999;33():227-40.
1998: Saeki Y; Ichikawa T; Saeki A; Chiocca E A; Tobler K; Ackermann M; Breakefield X O; Fraefel C
Herpes simplex virus type 1 DNA amplified as bacterial artificial chromosome in Escherichia coli: rescue of replication-competent virus progeny and packaging of amplicon vectors.
Human gene therapy 1998;9(18):2787-94.
1998: Yoon S S; Carroll N M; Chiocca E A; Tanabe K K
Cancer gene therapy using a replication-competent herpes simplex virus type 1 vector.
Annals of surgery 1998;228(3):366-74.
1998: Chung R Y; Chiocca E A
Gene therapy for tumors of the central nervous system.
Surgical oncology clinics of North America 1998;7(3):589-602.
1998: Herrlinger U; Kramm C M; Aboody-Guterman K S; Silver J S; Ikeda K; Johnston K M; Pechan P A; Barth R F; Finkelstein D; Chiocca E A; Louis D N; Breakefield X O
Pre-existing herpes simplex virus 1 (HSV-1) immunity decreases, but does not abolish, gene transfer to experimental brain tumors by a HSV-1 vector.
Gene therapy 1998;5(6):809-19.
1998: Rainov N G; Dobberstein K U; Sena-Esteves M; Herrlinger U; Kramm C M; Philpot R M; Hilton J; Chiocca E A; Breakefield X O
New prodrug activation gene therapy for cancer using cytochrome P450 4B1 and 2-aminoanthracene/4-ipomeanol.
Human gene therapy 1998;9(9):1261-73.
1998: Rainov N G; Dobberstein K U; Heidecke V; Dorant U; Chase M; Kramm C M; Chiocca E A; Breakefield X O
Long-term survival in a rodent brain tumor model by bradykinin-enhanced intra-arterial delivery of a therapeutic herpes simplex virus vector.
Cancer gene therapy 1998;5(3):158-62.
1998: Chase M; Chung R Y; Chiocca E A
An oncolytic viral mutant that delivers the CYP2B1 transgene and augments cyclophosphamide chemotherapy.
Nature biotechnology 1998;16(5):444-8.
1998: Moore A; Basilion J P; Chiocca E A; Weissleder R
Measuring transferrin receptor gene expression by NMR imaging.
Biochimica et biophysica acta 1998;1402(3):239-49.
1998: Wei M X; Li F; Ono Y; Gauldie J; Chiocca E A
Effects on brain tumor cell proliferation by an adenovirus vector that bears the interleukin-4 gene.
Journal of neurovirology 1998;4(2):237-41.
1998: Aghi M; Kramm C M; Chou T C; Breakefield X O; Chiocca E A
Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/cytosine deaminase gene therapies.
Journal of the National Cancer Institute 1998;90(5):370-80.
1998: Rainov N G; Sena-Esteves M; Fraefel C; Dobberstein K U; Chiocca E A; Breakefield X O
A chimeric fusion protein of cytochrome CYP4B1 and green fluorescent protein for detection of pro-drug activating gene delivery and for gene therapy in malignant glioma.
Advances in experimental medicine and biology 1998;451():393-403.
1997: Kramm C M; Chase M; Herrlinger U; Jacobs A; Pechan P A; Rainov N G; Sena-Esteves M; Aghi M; Barnett F H; Chiocca E A; Breakefield X O
Therapeutic efficiency and safety of a second-generation replication-conditional HSV1 vector for brain tumor gene therapy.
Human gene therapy 1997;8(17):2057-68.
1997: Ono Y; Ikeda K; Wei M X; Harsh G R; Tamiya T; Chiocca E A
Regression of experimental brain tumors with 6-thioxanthine and Escherichia coli gpt gene therapy.
Human gene therapy 1997;8(17):2043-55.
1997: Carroll N M; Chase M; Chiocca E A; Tanabe K K
The effect of ganciclovir on herpes simplex virus-mediated oncolysis.
The Journal of surgical research 1997;69(2):413-7.
1996: Pechan P A; Fotaki M; Thompson R L; Dunn R; Chase M; Chiocca E A; Breakefield X O
A novel 'piggyback' packaging system for herpes simplex virus amplicon vectors.
Human gene therapy 1996;7(16):2003-13.
1996: Kramm C M; Rainov N G; Sena-Esteves M; Barnett F H; Chase M; Herrlinger U; Pechan P A; Chiocca E A; Breakefield X O
Long-term survival in a rodent model of disseminated brain tumors by combined intrathecal delivery of herpes vectors and ganciclovir treatment.
Human gene therapy 1996;7(16):1989-94.
1996: Carroll N M; Chiocca E A; Takahashi K; Tanabe K K
Enhancement of gene therapy specificity for diffuse colon carcinoma liver metastases with recombinant herpes simplex virus.
Annals of surgery 1996;224(3):323-9; discussion 329-30.
1996: Tamiya T; Ono Y; Wei M X; Mroz P J; Moolten F L; Chiocca E A
Escherichia coli gpt gene sensitizes rat glioma cells to killing by 6-thioxanthine or 6-thioguanine.
Cancer gene therapy 1996;3(3):155-62.
1996: Kramm C M; Rainov N G; Sena-Esteves M; Chase M; Pechan P A; Chiocca E A; Breakefield X O
Herpes vector-mediated delivery of marker genes to disseminated central nervous system tumors.
Human gene therapy 1996;7(3):291-300.
1995: Rainov N G; Zimmer C; Chase M; Kramm C M; Chiocca E A; Weissleder R; Breakefield X O
Selective uptake of viral and monocrystalline particles delivered intra-arterially to experimental brain neoplasms.
Human gene therapy 1995;6(12):1543-52.
1995: Wei M X; Tamiya T; Rhee R J; Breakefield X O; Chiocca E A
Diffusible cytotoxic metabolites contribute to the in vitro bystander effect associated with the cyclophosphamide/cytochrome P450 2B1 cancer gene therapy paradigm.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(10):1171-7.
1995: Kramm C M; Sena-Esteves M; Barnett F H; Rainov N G; Schuback D E; Yu J S; Pechan P A; Paulus W; Chiocca E A; Breakefield X O
Gene therapy for brain tumors.
Brain pathology (Zurich, Switzerland) 1995;5(4):345-81.
1995: Tamiya T; Wei M X; Chase M; Ono Y; Lee F; Breakefield X O; Chiocca E A
Transgene inheritance and retroviral infection contribute to the efficiency of gene expression in solid tumors inoculated with retroviral vector producer cells.
Gene therapy 1995;2(8):531-8.
1995: Wei M X; Tamiya T; Hurford R K; Boviatsis E J; Tepper R I; Chiocca E A
Enhancement of interleukin-4-mediated tumor regression in athymic mice by in situ retroviral gene transfer.
Human gene therapy 1995;6(4):437-43.
1994: Boviatsis E J; Park J S; Sena-Esteves M; Kramm C M; Chase M; Efird J T; Wei M X; Breakefield X O; Chiocca E A
Long-term survival of rats harboring brain neoplasms treated with ganciclovir and a herpes simplex virus vector that retains an intact thymidine kinase gene.
Cancer research 1994;54(22):5745-51.
1994: Chiocca E A; Boviatsis E J; Westmark R M; Short M P; Richardson E P; Zervas N T
Deep sylvian fissure meningioma without dural attachment in an adult: case report.
Neurosurgery 1994;35(5):944-6; discussion 946.
1994: Boviatsis E J; Scharf J M; Chase M; Harrington K; Kowall N W; Breakefield X O; Chiocca E A
Antitumor activity and reporter gene transfer into rat brain neoplasms inoculated with herpes simplex virus vectors defective in thymidine kinase or ribonucleotide reductase.
Gene therapy 1994;1(5):323-31.
1994: Wei M X; Tamiya T; Chase M; Boviatsis E J; Chang T K; Kowall N W; Hochberg F H; Waxman D J; Breakefield X O; Chiocca E A
Experimental tumor therapy in mice using the cyclophosphamide-activating cytochrome P450 2B1 gene.
Human gene therapy 1994;5(8):969-78.
1994: Boviatsis E J; Chase M; Wei M X; Tamiya T; Hurford R K; Kowall N W; Tepper R I; Breakefield X O; Chiocca E A
Gene transfer into experimental brain tumors mediated by adenovirus, herpes simplex virus, and retrovirus vectors.
Human gene therapy 1994;5(2):183-91.
1993: Yu J S; Wei M X; Chiocca E A; Martuza R L; Tepper R I
Treatment of glioma by engineered interleukin 4-secreting cells.
Cancer research 1993;53(13):3125-8.
1992: Lee J K; Sobel R A; Chiocca E A; Kim T S; Martuza R L
Growth of human acoustic neuromas, neurofibromas and schwannomas in the subrenal capsule and sciatic nerve of the nude mouse.
Journal of neuro-oncology 1992;14(2):101-12.
1991: Gentile V; Saydak M; Chiocca E A; Akande O; Birckbichler P J; Lee K N; Stein J P; Davies P J
Isolation and characterization of cDNA clones to mouse macrophage and human endothelial cell tissue transglutaminases.
The Journal of biological chemistry 1991;266(1):478-83.
1990: Lee J K; Choi B; Sobel R A; Chiocca E A; Martuza R L
Inhibition of growth and angiogenesis of human neurofibrosarcoma by heparin and hydrocortisone.
Journal of neurosurgery 1990;73(3):429-35.
1990: Chiocca E A; Choi B B; Cai W Z; DeLuca N A; Schaffer P A; DiFiglia M; Breakefield X O; Martuza R L
Transfer and expression of the lacZ gene in rat brain neurons mediated by herpes simplex virus mutants.
The New biologist 1990;2(8):739-46.
1990: Lee J K; Kim T S; Chiocca E A; Medhkour A; Martuza R L
Growth of human schwannomas in the subrenal capsule of the nude mouse.
Neurosurgery 1990;26(4):598-605.
1989: Chiocca E A; Davies P J; Stein J P
Regulation of tissue transglutaminase gene expression as a molecular model for retinoid effects on proliferation and differentiation.
Journal of cellular biochemistry 1989;39(3):293-304.
1988: Davies P J; Basilion J P; Chiocca E A; Johnson J; Poddar S; Stein J P
Retinoids as generalized regulators of cellular growth and differentiation.
The American journal of the medical sciences 1988;296(3):164-70.
1988: Chiocca E A; Davies P J; Stein J P
The molecular basis of retinoic acid action. Transcriptional regulation of tissue transglutaminase gene expression in macrophages.
The Journal of biological chemistry 1988;263(23):11584-9.
1988: Davies P J; Chiocca E A; Basilion J P; Poddar S; Stein J P
Transglutaminases and their regulation: implications for polyamine metabolism.
Advances in experimental medicine and biology 1988;250():391-401.
1988: Davies P J; Chiocca E A; Stein J P
Retinoid--regulated expression of tissue transglutaminase in normal and leukemic myeloid cells.
Advances in experimental medicine and biology 1988;231():63-71.

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