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John Chiorini

Research Profile

Living Beings

Chemicals & Drugs

Physiology

Transduction, Genetic

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Gene Transfer Techniques

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Molecular Sequence Data

Anatomy

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Sjogren's Syndrome

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Publications

TOP 3
Eduardo M Rocha; Changyu Zheng; Bruce J Baum; Ana P Cotrim; Paola Perez Riveros; John A Chiorini
Recovery of radiation-induced dry eye and corneal damage by pretreatment with adenoviral vector-mediated transfer of erythropoietin to the salivary glands in mice.
Jason C Steel; John A Chiorini; Giovanni Di Pasquale; Vyomesh Patel; Charmaine A Ramlogan; John C Morris
Oral vaccination with adeno-associated virus vectors expressing the Neu oncogene inhibits the growth of murine breast cancer.
Bruce J Baum; Jaime Brahim; Peter D Burbelo; Clara C Chen; John A Chiorini; Deborah E Citrin; Ana P Cotrim; Stamatina Danielides; Corinne M Goldsmith; Shuying Liu; Linda McCullagh; James B Mitchell; Nikolay P Nikolov; Liesl K Nottingham; Nicholas J Patronas; Susan F Rudy; R James Turner; Carter Van Waes; Millie A Whatley; Changyu Zheng; Ilias Alevizos; Gabor G Illei
Early responses to adenoviral-mediated transfer of the aquaporin-1 cDNA for radiation-induced salivary hypofunction.

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All Publications

2013: Eduardo M Rocha; Changyu Zheng; Bruce J Baum; Ana P Cotrim; Paola Perez Riveros; John A Chiorini
Recovery of radiation-induced dry eye and corneal damage by pretreatment with adenoviral vector-mediated transfer of erythropoietin to the salivary glands in mice.
Human gene therapy 2013;24(4):417-23.
2013: Jason C Steel; John A Chiorini; Giovanni Di Pasquale; Vyomesh Patel; Charmaine A Ramlogan; John C Morris
Oral vaccination with adeno-associated virus vectors expressing the Neu oncogene inhibits the growth of murine breast cancer.
Molecular therapy : the journal of the American Society of Gene Therapy 2013;21(3):680-7.
2012: Bruce J Baum; Jaime Brahim; Peter D Burbelo; Clara C Chen; John A Chiorini; Deborah E Citrin; Ana P Cotrim; Stamatina Danielides; Corinne M Goldsmith; Shuying Liu; Linda McCullagh; James B Mitchell; Nikolay P Nikolov; Liesl K Nottingham; Nicholas J Patronas; Susan F Rudy; R James Turner; Carter Van Waes; Millie A Whatley; Changyu Zheng; Ilias Alevizos; Gabor G Illei
Early responses to adenoviral-mediated transfer of the aquaporin-1 cDNA for radiation-induced salivary hypofunction.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(47):19403-7.
2012: Ingo H Pilz; Agnieszka Rzadzinska; Giovanni Di Pasquale; Stephen H Leppla; John A Chiorini
Mutation in the platelet-derived growth factor receptor alpha inhibits adeno-associated virus type 5 transduction.
Virology 2012;428(1):58-63.
2012: J L Vosters; N Roescher; John A Chiorini; Gabor G Illei; P P Tak
TACI-Fc gene therapy improves autoimmune sialadenitis but not salivary gland function in non-obese diabetic mice.
Oral diseases 2012;18(4):365-74.
2012: Giovanni Di Pasquale; Philip H Karp; L Ostedgaard; William D Swaim; Daniel W Vermeer; John A Chiorini
Bovine AAV transcytosis inhibition by tannic acid results in functional expression of CFTR in vitro and altered biodistribution in vivo.
Gene therapy 2012;19(5):576-81.
2012: Carole E Harbison; Mavis Agbandje-McKenna; John A Chiorini; Brittney L Gurda; Wendy S Weichert; Colin R Parrish
Examining the cross-reactivity and neutralization mechanisms of a panel of mAbs against adeno-associated virus serotypes 1 and 5.
The Journal of general virology 2012;93(Pt 2):347-55.
2012: Nienke Roescher; Paul P Tak; Toshimitsu Uede; Jelle L Vosters; Zhenan Lai; John A Chiorini
Local administration of soluble CD40:Fc to the salivary glands of non-obese diabetic mice does not ameliorate autoimmune inflammation.
PloS one 2012;7(12):e51375.
2012: Giovanni Di Pasquale; Ilaria Dicembrini; Josephine M Egan; Andrea Loreto; Mario Maggi; Maria E Manni; Edoardo Mannucci; Drew G Michael; Annamaria Morelli; Claudio Pagano; Laura Raimondi; Silvia Berretti; John A Chiorini; Lorenzo Cinci; Andrea Cozzi; Roberto Vettor; Changyu Zheng; Carlo M Rotella
Sustained exendin-4 secretion through gene therapy targeting salivary glands in two different rodent models of obesity/type 2 diabetes.
PloS one 2012;7(7):e40074.
2012: Hongen Yin; Cuong Q Nguyen; Ammon B Peck; Yuval Samuni; Toshimitsu Uede; John A Chiorini
Local delivery of AAV2-CTLA4IgG decreases sialadenitis and improves gland function in the C57BL/6.NOD-Aec1Aec2 mouse model of Sjögren's syndrome.
Arthritis research & therapy 2012;14(1):R40.
2011: Kathrina Quinn; Mary R Quirion; Suzanne L Epstein; Chia-Yun Lo; Julia A Misplon; John A Chiorini
Intranasal administration of adeno-associated virus type 12 (AAV12) leads to transduction of the nasal epithelia and can initiate transgene-specific immune response.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(11):1990-8.
2011: D Michael; S Soi; M Weller; Gabor G Illei; I Alevizos; S Alexander; J Cabera-Perez; John A Chiorini
Microarray analysis of sexually dimorphic gene expression in human minor salivary glands.
Oral diseases 2011;17(7):653-61.
2011: Chingakham Ranjit Singh; Ryosuke Watanabe; Ronald C Wek; Donghui Zhou; Mark Ashe; Susan G Campbell; John A Chiorini; Toshinobu Fujiwara; Akira Fukao; Yuka Ikeda; Martin D Jennings; Bumjun Lee; Graham D Pavitt; Katsura Asano
Mechanisms of translational regulation by a human eIF5-mimic protein.
Nucleic acids research 2011;39(19):8314-28.
2011: Changyu Zheng; Sandra Afione; Molly Boyle; John A Chiorini; Tim Clackson; Benjamin Goldstein; Richard D Irwin; Abraham Nyska; Victor M Rivera; Molly K Vallant; Antonis Voutetakis; Martin L Wenk; Bruce J Baum
Assessment of the safety and biodistribution of a regulated AAV2 gene transfer vector after delivery to murine submandibular glands.
Toxicological sciences : an official journal of the Society of Toxicology 2011;123(1):247-55.
2011: Melinda A Brindley; Catherine Leta Hunt; Andrew S Kondratowicz; Jill Bowman; Patrick L Sinn; Paul B McCray; Kathrina Quinn; Melodie L Weller; John A Chiorini; Wendy Maury
Tyrosine kinase receptor Axl enhances entry of Zaire ebolavirus without direct interactions with the viral glycoprotein.
Virology 2011;415(2):83-94.
2011: Andrew S Kondratowicz; Nicholas J Lennemann; Patrick L Sinn; Robert A Davey; Catherine Leta Hunt; Sven Moller-Tank; David K Meyerholz; Paul Rennert; robert Mullins; Melinda Brindley; Lindsay M Sandersfeld; Kathrina Quinn; Melodie Weller; Paul B McCray; John A Chiorini; Wendy Maury
T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(20):8426-31.
2011: Giulia Crispino; Romolo Daniele De Siati; Giovanni Di Pasquale; Fabian Galindo Ramirez; Edoardo Arslan; Mario Bortolozzi; John A Chiorini; Laura Rodriguez; Rosa Maria Santarelli; Pietro Scimemi; Fabio Mammano
BAAV mediated GJB2 gene transfer restores gap junction coupling in cochlear organotypic cultures from deaf Cx26Sox10Cre mice.
PloS one 2011;6(8):e23279.
2011: Anne M Rowzee; Niamh X Cawley; John A Chiorini; Giovanni Di Pasquale
Glucagon-like peptide-1 gene therapy.
Experimental diabetes research 2011;2011():601047.
2011: Nienke Roescher; Jelle L Vosters; Hongen Yin; Gabor G Illei; Paul P Tak; John A Chiorini
Effect of soluble ICAM-1 on a Sjögren's syndrome-like phenotype in NOD mice is disease stage dependent.
PloS one 2011;6(5):e19962.
2011: Hongen Yin; Jelle L Vosters; Nienke Roescher; Anil D'Souza; Biji T Kurien; Paul P Tak; John A Chiorini
Location of immunization and interferon-γ are central to induction of salivary gland dysfunction in Ro60 peptide immunized model of Sjögren's syndrome.
PloS one 2011;6(3):e18003.
2011: R Gao; X Yan; Changyu Zheng; Corinne M Goldsmith; Sandra Afione; B Hai; Jianguo Xu; Jing Zhou; Chunmei Zhang; John A Chiorini; Bruce J Baum; Shixuan Wang
AAV2-mediated transfer of the human aquaporin-1 cDNA restores fluid secretion from irradiated miniature pig parotid glands.
Gene therapy 2011;18(1):38-42.
2011: Cuong Q Nguyen; Hongen Yin; Byung Ha Lee; John A Chiorini; Ammon B Peck
IL17: potential therapeutic target in Sjögren's syndrome using adenovirus-mediated gene transfer.
Laboratory investigation; a journal of technical methods and pathology 2011;91(1):54-62.
2010: Tomohiro Onodera; Takayoshi Sakai; Jeff Chi-feng Hsu; Kazue Matsumoto; John A Chiorini; Kenneth M Yamada
Btbd7 regulates epithelial cell dynamics and branching morphogenesis.
Science (New York, N.Y.) 2010;329(5991):562-5.
2010: Melodie L Weller; Panomwat Amornphimoltham; Michael Schmidt; Paul A Wilson; J Silvio Gutkind; John A Chiorini
Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6.
Nature medicine 2010;16(6):662-4.
2010: Changyu Zheng; Antonis Voutetakis; M Metzger; Sandra Afione; Ana P Cotrim; Michael Eckhaus; V M Rivera; Tim Clackson; John A Chiorini; R E Donahue; C E Dunbar; Bruce J Baum
Evaluation of a rapamycin-regulated serotype 2 adeno-associated viral vector in macaque parotid glands.
Oral diseases 2010;16(3):269-77.
2010: Kaoru Hida; Sang Y Won; Giovanni Di Pasquale; Justin Hanes; John A Chiorini; Marc Ostermeier
Sites in the AAV5 capsid tolerant to deletions and tandem duplications.
Archives of biochemistry and biophysics 2010;496(1):1-8.
2010: Cuong Q Nguyen; Hongen Yin; Byung Ha Lee; Wendy C Carcamo; John A Chiorini; Ammon B Peck
Pathogenic effect of interleukin-17A in induction of Sjögren's syndrome-like disease using adenovirus-mediated gene transfer.
Arthritis research & therapy 2010;12(6):R220.
2010: Giovanni Di Pasquale; Nikola Kaludov; Mavis Agbandje-McKenna; John A Chiorini
BAAV transcytosis requires an interaction with beta-1-4 linked- glucosamine and gp96.
PloS one 2010;5(3):e9336.
2010: Changyu Zheng; Nikolay P Nikolov; Ilias Alevizos; Ana P Cotrim; Shuying Liu; Linda McCullagh; John A Chiorini; Gabor G Illei; Bruce J Baum
Transient detection of E1-containing adenovirus in saliva after the delivery of a first-generation adenoviral vector to human parotid gland.
The journal of gene medicine 2010;12(1):3-10.
2010: Bruce J Baum; Changyu Zheng; Ilias Alevizos; Ana P Cotrim; Shuying Liu; Linda McCullagh; Corinne M Goldsmith; Nancy McDermott; John A Chiorini; Nikolay P Nikolov; Gabor G Illei
Development of a gene transfer-based treatment for radiation-induced salivary hypofunction.
Oral oncology 2010;46(1):4-8.
2010: Antonis Voutetakis; Changyu Zheng; Ana P Cotrim; Fumi Mineshiba; Sandra Afione; N Roescher; William D Swaim; M Metzger; Michael Eckhaus; R E Donahue; C E Dunbar; John A Chiorini; Bruce J Baum
AAV5-mediated gene transfer to the parotid glands of non-human primates.
Gene therapy 2010;17(1):50-60.
2009: Jelle L Vosters; Melissa A Landek-Salgado; Hongen Yin; William D Swaim; Hiroaki Kimura; Paul P Tak; Patrizio Caturegli; John A Chiorini
Interleukin-12 induces salivary gland dysfunction in transgenic mice, providing a new model of Sjögren's syndrome.
Arthritis and rheumatism 2009;60(12):3633-41.
2009: Kathrina Quinn; Melinda A Brindley; Melodie L Weller; Nikola Kaludov; Andrew Kondratowicz; Catherine Leta Hunt; Patrick L Sinn; Paul B McCray; Colleen S Stein; Beverly L Davidson; Ramon Flick; Robert Mandell; William Staplin; Wendy Maury; John A Chiorini
Rho GTPases modulate entry of Ebola virus and vesicular stomatitis virus pseudotyped vectors.
Journal of virology 2009;83(19):10176-86.
2009: Bo Hai; Xing Yan; Antonis Voutetakis; Changyu Zheng; Ana P Cotrim; Zhaochen Shan; Gang Ding; Chunmei Zhang; Junji Xu; Corinne M Goldsmith; Sandra Afione; John A Chiorini; Bruce J Baum; Songlin Wang
Long-term transduction of miniature pig parotid glands using serotype 2 adeno-associated viral vectors.
The journal of gene medicine 2009;11(6):506-14.
2009: Jelle L Vosters; Hongen Yin; Nienke Roescher; Marc R Kok; Paul P Tak; John A Chiorini
Local expression of tumor necrosis factor-receptor 1:immunoglobulin G can induce salivary gland dysfunction in a murine model of Sjögren's syndrome.
Arthritis research & therapy 2009;11(6):R189.
2009: Anthony T Craig; Oksana Gavrilova; Nancy K Dwyer; William Jou; Stephanie Pack; Eric Liu; Klaus Pechhold; Michael Schmidt; Victor J McAlister; John A Chiorini; E Joan Blanchette-Mackie; David M Harlan; Roland A Owens
Transduction of rat pancreatic islets with pseudotyped adeno-associated virus vectors.
Virology journal 2009;6():61.
2008: Saida Ortolano; Giovanni Di Pasquale; Giulia Crispino; Fabio Anselmi; Fabio Mammano; John A Chiorini
Coordinated control of connexin 26 and connexin 30 at the regulatory and functional level in the inner ear.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(48):18776-81.
2008: Michael Schmidt; Lakshmanan Govindasamy; Sandra Afione; Nikola Kaludov; Mavis Agbandje-McKenna; John A Chiorini
Molecular characterization of the heparin-dependent transduction domain on the capsid of a novel adeno-associated virus isolate, AAV(VR-942).
Journal of virology 2008;82(17):8911-6.
2008: Changyu Zheng; Joseph M Vitolo; Weitian Zhang; Fumi Mineshiba; John A Chiorini; Bruce J Baum
Extended transgene expression from a nonintegrating adenoviral vector containing retroviral elements.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(6):1089-97.
2008: Carole E Harbison; John A Chiorini; Colin R Parrish
The parvovirus capsid odyssey: from the cell surface to the nucleus.
Trends in microbiology 2008;16(5):208-14.
2008: Michael Schmidt; Antonis Voutetakis; Sandra Afione; Changyu Zheng; Danielle Mandikian; John A Chiorini
Adeno-associated virus type 12 (AAV12): a novel AAV serotype with sialic acid- and heparan sulfate proteoglycan-independent transduction activity.
Journal of virology 2008;82(3):1399-406.
2007: Antonis Voutetakis; Changyu Zheng; Jianghua Wang; Corinne M Goldsmith; Sandra Afione; John A Chiorini; M L Wenk; Molly K Vallant; Richard D Irwin; Bruce J Baum
Gender differences in serotype 2 adeno-associated virus biodistribution after administration to rodent salivary glands.
Human gene therapy 2007;18(11):1109-18.
2007: Antonis Voutetakis; Changyu Zheng; Fumi Mineshiba; Ana P Cotrim; Corinne M Goldsmith; Michael Schmidt; Sandra Afione; Nienke Roescher; Mark Metzger; Michael Eckhaus; John A Chiorini; Cynthia E Dunbar; Robert E Donahue; Bruce J Baum
Adeno-associated virus serotype 2-mediated gene transfer to the parotid glands of nonhuman primates.
Human gene therapy 2007;18(2):142-50.
2007: Gumei Liu; Yong Hong Chen; Xiaohua He; Inês Martins; Jason A Heth; John A Chiorini; Beverly L Davidson
Adeno-associated virus type 5 reduces learning deficits and restores glutamate receptor subunit levels in MPS VII mice CNS.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(2):242-7.
2006: Lakshmanan Govindasamy; Eric Padron; Robert McKenna; Nicholas Muzyczka; Nikola Kaludov; John A Chiorini; Mavis Agbandje-McKenna
Structurally mapping the diverse phenotype of adeno-associated virus serotype 4.
Journal of virology 2006;80(23):11556-70.
2006: Changyu Zheng; Corinne M Goldsmith; Fumi Mineshiba; John A Chiorini; Andrew Kerr; Martin L Wenk; Molly K Vallant; Richard D Irwin; Bruce J Baum
Toxicity and biodistribution of a first-generation recombinant adenoviral vector, encoding aquaporin-1, after retroductal delivery to a single rat submandibular gland.
Human gene therapy 2006;17(11):1122-33.
2006: Simon D Tran; Takayuki Sugito; Giovanni Dipasquale; Ana P Cotrim; Bidhan Bandyopadhyay; Kathryn Riddle; David Mooney; Marc R Kok; John A Chiorini; Bruce J Baum
Re-engineering primary epithelial cells from rhesus monkey parotid glands for use in developing an artificial salivary gland.
Tissue engineering 2006;12(10):2939-48.
2006: Bruce J Baum; Changyu Zheng; Ana P Cotrim; Corinne M Goldsmith; Jane C Atkinson; Jaime Brahim; John A Chiorini; Antonis Voutetakis; Rose Anne Leakan; Carter Van Waes; James B Mitchell; Christine Delporte; Songlin Wang; Stephen M Kaminsky; Gabor G Illei
Transfer of the AQP1 cDNA for the correction of radiation-induced salivary hypofunction.
Biochimica et biophysica acta 2006;1758(8):1071-7.
2006: Michael Schmidt; John A Chiorini
Gangliosides are essential for bovine adeno-associated virus entry.
Journal of virology 2006;80(11):5516-22.
2006: Michael Schmidt; Emmanuelle Grot; Peter Cervenka; Sandra Wainer; Charles Buck; John A Chiorini
Identification and characterization of novel adeno-associated virus isolates in ATCC virus stocks.
Journal of virology 2006;80(10):5082-5.
2006: Hisako Katano; Marc R Kok; Ana P Cotrim; Seiichi Yamano; Michael Schmidt; Sandra Afione; Bruce J Baum; John A Chiorini
Enhanced transduction of mouse salivary glands with AAV5-based vectors.
Gene therapy 2006;13(7):594-601.
2006: Giovanni Di Pasquale; John A Chiorini
AAV transcytosis through barrier epithelia and endothelium.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;13(3):506-16.
2006: Jin Zhong Li; Hongwei Li; Gerald R Hankins; Ann-Shung Lieu; El Noh; Lindsey Jacobson; Debra D Pittman; John A Chiorini; Gregory A Helm
Different osteogenic potentials of recombinant human BMP-6 adeno-associated virus and adenovirus in two rat strains.
Tissue engineering 2006;12(2):209-19.
2005: Gumei Liu; Inês Martins; John A Wemmie; John A Chiorini; Beverly L Davidson
Functional correction of CNS phenotypes in a lysosomal storage disease model using adeno-associated virus type 4 vectors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(41):9321-7.
2005: Michael DiMattia; Lakshmanan Govindasamy; Hazel C Levy; Brittney Gurda-Whitaker; Amy Kalina; Erik Kohlbrenner; John A Chiorini; Robert McKenna; Nicholas Muzyczka; Sergei Zolotukhin; Mavis Agbandje-McKenna
Production, purification, crystallization and preliminary X-ray structural studies of adeno-associated virus serotype 5.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 10):917-21.
2005: Gumei Liu; Inês H Martins; John A Chiorini; Beverly L Davidson
Adeno-associated virus type 4 (AAV4) targets ependyma and astrocytes in the subventricular zone and RMS.
Gene therapy 2005;12(20):1503-8.
2005: Antonis Voutetakis; Ioannis Bossis; Marc R Kok; Weitian Zhang; Jianghua Wang; Ana P Cotrim; Changyu Zheng; John A Chiorini; Lynnette K Nieman; Bruce J Baum
Salivary glands as a potential gene transfer target for gene therapeutics of some monogenetic endocrine disorders.
The Journal of endocrinology 2005;185(3):363-72.
2005: Giovanni Di Pasquale; Agnieszka Rzadzinska; Mark E Schneider; Ioannis Bossis; John A Chiorini; Anne E White-Olson
A novel bovine virus efficiently transduces inner ear neuroepithelial cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;11(6):849-55.
2005: Eric Padron; valorie bowman; Nikola Kaludov; Lakshmanan Govindasamy; Hazel Levy; Phillip Nick; Robert McKenna; Nicholas Muzyczka; John A Chiorini; Timothy S Baker; Mavis Agbandje-McKenna
Structure of adeno-associated virus type 4.
Journal of virology 2005;79(8):5047-58.
2005: Marc R Kok; Antonis Voutetakis; Seiichi Yamano; Jianghua Wang; Ana P Cotrim; Hisako Katano; Ioannis Bossis; John A Chiorini; Simon D Tran; Paul P Tak; Bruce J Baum
Immune responses following salivary gland administration of recombinant adeno-associated virus serotype 2 vectors.
The journal of gene medicine 2005;7(4):432-41.
2005: Lynda S Ostedgaard; Tatiana Rokhlina; Philip H Karp; Philip E Lashmit; Sandra Afione; Michael Schmidt; Joseph Zabner; Mark F Stinski; John A Chiorini; Michael J Welsh
A shortened adeno-associated virus expression cassette for CFTR gene transfer to cystic fibrosis airway epithelia.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(8):2952-7.
2004: Michael Schmidt; Hisako Katano; Ioannis Bossis; John A Chiorini
Cloning and characterization of a bovine adeno-associated virus.
Journal of virology 2004;78(12):6509-16.
2004: Hisako Katano; Sandra Afione; Michael Schmidt; John A Chiorini
Identification of adeno-associated virus contamination in cell and virus stocks by PCR.
BioTechniques 2004;36(4):676-80.
2004: Robert Walters; Mavis Agbandje-McKenna; valorie bowman; Thomas O Moninger; Norman H Olson; Michael Seiler; John A Chiorini; Timothy S Baker; Joseph Zabner
Structure of adeno-associated virus serotype 5.
Journal of virology 2004;78(7):3361-71.
2004: Antonis Voutetakis; Marc R Kok; Changyu Zheng; Ioannis Bossis; Jianghua Wang; Ana P Cotrim; Natanya Marracino; Corinne M Goldsmith; John A Chiorini; Y Peng Loh; Lynnette K Nieman; Bruce J Baum
Reengineered salivary glands are stable endogenous bioreactors for systemic gene therapeutics.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):3053-8.
2003: Andrew J Lotery; Grace S Yang; robert Mullins; Stephen R Russell; Michael Schmidt; Edwin M Stone; Jonathan D Lindbloom; John A Chiorini; robert kotin; Beverly L Davidson
Adeno-associated virus type 5: transduction efficiency and cell-type specificity in the primate retina.
Human gene therapy 2003;14(17):1663-71.
2003: Marc R Kok; Seiichi Yamano; Beatrijs M Lodde; Jianghua Wang; Ross I Couwenhoven; Shoshana Yakar; Antonis Voutetakis; Derek LeRoith; Michael Schmidt; Sandra Afione; Stanley R Pillemer; Marjorie T Tsutsui; Paul P Tak; John A Chiorini; Bruce J Baum
Local adeno-associated virus-mediated interleukin 10 gene transfer has disease-modifying effects in a murine model of Sjögren's syndrome.
Human gene therapy 2003;14(17):1605-18.
2003: Giovanni Di Pasquale; Beverly L Davidson; Colleen S Stein; Inês Martins; Dominic A Scudiero; Anne Monks; John A Chiorini
Identification of PDGFR as a receptor for AAV-5 transduction.
Nature medicine 2003;9(10):1306-12.
2003: Ioannis Bossis; John A Chiorini
Cloning of an avian adeno-associated virus (AAAV) and generation of recombinant AAAV particles.
Journal of virology 2003;77(12):6799-810.
2003: Giovanni Di Pasquale; John A Chiorini
PKA/PrKX activity is a modulator of AAV/adenovirus interaction.
The EMBO journal 2003;22(7):1716-24.
2003: Nikola Kaludov; Eric Padron; Lakshmanan Govindasamy; Robert McKenna; John A Chiorini; Mavis Agbandje-McKenna
Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 4.
Virology 2003;306(1):1-6.
2003: Beverly L Davidson; John A Chiorini
Recombinant adeno-associated viral vector types 4 and 5. Preparation and application for CNS gene transfer.
Methods in molecular medicine 2003;76():269-85.
2003: RE Haskell; Stephanie Hughes; John A Chiorini; Joseph Martin Alisky; Beverly L Davidson
Viral-mediated delivery of the late-infantile neuronal ceroid lipofuscinosis gene, TPP-I to the mouse central nervous system.
Gene therapy 2003;10(1):34-42.
2002: Cyril P Rooney; Gerene M Denning; B P Davis; Dawn M Flaherty; John A Chiorini; Joseph Zabner
Bronchoalveolar fluid is not a major hindrance to virus-mediated gene therapy in cystic fibrosis.
Journal of virology 2002;76(20):10437-43.
2002: Nikola Kaludov; Beverly Handelman; John A Chiorini
Scalable purification of adeno-associated virus type 2, 4, or 5 using ion-exchange chromatography.
Human gene therapy 2002;13(10):1235-43.
2002: Robert Walters; Joseph M Pilewski; John A Chiorini; Joseph Zabner
Secreted and transmembrane mucins inhibit gene transfer with AAV4 more efficiently than AAV5.
The Journal of biological chemistry 2002;277(26):23709-13.
2002: Michael Schmidt; John A Chiorini; Sandra Afione; robert kotin
Adeno-associated virus type 2 Rep78 inhibition of PKA and PRKX: fine mapping and analysis of mechanism.
Journal of virology 2002;76(3):1033-42.
2002: Seiichi Yamano; Li-Yun Huang; Chuantian Ding; John A Chiorini; Corinne M Goldsmith; Robert B Wellner; Basil Golding; robert kotin; Dorothy E Scott; Bruce J Baum
Recombinant adeno-associated virus serotype 2 vectors mediate stable interleukin 10 secretion from salivary glands into the bloodstream.
Human gene therapy 2002;13(2):287-98.
2001: Seiichi Yamano; Dorothy E Scott; Li-Yun Huang; Malgorzata G Mikolajczyk; Stanley R Pillemer; John A Chiorini; Basil Golding; Bruce J Baum
Protection from experimental endotoxemia by a recombinant adeno-associated virus encoding interleukin 10.
The journal of gene medicine 2001;3(5):450-7.
2001: Nikola Kaludov; K E Brown; Robert Walters; Joseph Zabner; John A Chiorini
Adeno-associated virus serotype 4 (AAV4) and AAV5 both require sialic acid binding for hemagglutination and efficient transduction but differ in sialic acid linkage specificity.
Journal of virology 2001;75(15):6884-93.
2001: Robert Walters; Su Min P Yi; Shaf Keshavjee; K E Brown; Michael J Welsh; John A Chiorini; Joseph Zabner
Binding of adeno-associated virus type 5 to 2,3-linked sialic acid is required for gene transfer.
The Journal of biological chemistry 2001;276(23):20610-6.
2000: Joseph Martin Alisky; Stephanie Hughes; Sybille L Sauter; D Jolly; Thomas W Dubensky; Patrick D Staber; John A Chiorini; Beverly L Davidson
Transduction of murine cerebellar neurons with recombinant FIV and AAV5 vectors.
Neuroreport 2000;11(12):2669-73.
2000: Joseph Zabner; Michael Seiler; R Walters; robert kotin; W Fulgeras; Beverly L Davidson; John A Chiorini
Adeno-associated virus type 5 (AAV5) but not AAV2 binds to the apical surfaces of airway epithelia and facilitates gene transfer.
Journal of virology 2000;74(8):3852-8.
2000: Beverly L Davidson; Colleen S Stein; Jason A Heth; Inês Martins; robert kotin; Todd A Derksen; Joseph Zabner; Abdi Ghodsi; John A Chiorini
Recombinant adeno-associated virus type 2, 4, and 5 vectors: transduction of variant cell types and regions in the mammalian central nervous system.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(7):3428-32.
2000: Paola T Drapkin; Catherine R O'Riordan; Su Min P Yi; John A Chiorini; J Cardella; Joseph Zabner; Michael J Welsh
Targeting the urokinase plasminogen activator receptor enhances gene transfer to human airway epithelia.
The Journal of clinical investigation 2000;105(5):589-96.
1999: John A Chiorini; Sandra Afione; robert kotin
Adeno-associated virus (AAV) type 5 Rep protein cleaves a unique terminal resolution site compared with other AAV serotypes.
Journal of virology 1999;73(5):4293-8.
1999: Bastian Zimmermann; John A Chiorini; Y Ma; robert kotin; Friedrich W Herberg
PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I.
The Journal of biological chemistry 1999;274(9):5370-8.
1999: John A Chiorini; S Miyamoto; S J Harkin; B Safer
Genomic cloning and characterization of the human eukaryotic initiation factor-2beta promoter.
The Journal of biological chemistry 1999;274(7):4195-201.
1999: John A Chiorini; F Kim; Linda Yang; robert kotin
Cloning and characterization of adeno-associated virus type 5.
Journal of virology 1999;73(2):1309-19.
1998: VR Braddon; John A Chiorini; S Wang; robert kotin; Bruce J Baum
Adenoassociated virus-mediated transfer of a functional water channel into salivary epithelial cells in vitro and in vivo.
Human gene therapy 1998;9(18):2777-85.
1998: John A Chiorini; Bastian Zimmermann; Linda Yang; Richard H Smith; A Ahearn; Friedrich W Herberg; robert kotin
Inhibition of PrKX, a novel protein kinase, and the cyclic AMP-dependent protein kinase PKA by the regulatory proteins of adeno-associated virus type 2.
Molecular and cellular biology 1998;18(10):5921-9.
1997: John A Chiorini; Linda Yang; Y Liu; B Safer; robert kotin
Cloning of adeno-associated virus type 4 (AAV4) and generation of recombinant AAV4 particles.
Journal of virology 1997;71(9):6823-33.
1997: Clemens-Martin Wendtner; A Nolte; E Mangold; Raymund Buhmann; G Maass; John A Chiorini; E L Winnacker; B Emmerich; robert kotin; Michael Hallek
Gene transfer of the costimulatory molecules B7-1 and B7-2 into human multiple myeloma cells by recombinant adeno-associated virus enhances the cytolytic T cell response.
Gene therapy 1997;4(7):726-35.
1996: S Miyamoto; John A Chiorini; E Urcelay; B Safer
Regulation of gene expression for translation initiation factor eIF-2 alpha: importance of the 3' untranslated region.
The Biochemical journal 1996;315 ( Pt 3)():791-8.
1996: John A Chiorini; S M Wiener; Linda Yang; Richard H Smith; B Safer; N P Kilcoin; Y Liu; E Urcelay; robert kotin
The roles of AAV Rep proteins in gene expression and targeted integration.
Current topics in microbiology and immunology 1996;218():25-33.
1995: John A Chiorini; Clemens-Martin Wendtner; E Urcelay; B Safer; Michael Hallek; robert kotin
High-efficiency transfer of the T cell co-stimulatory molecule B7-2 to lymphoid cells using high-titer recombinant adeno-associated virus vectors.
Human gene therapy 1995;6(12):1531-41.
1995: John A Chiorini; L Yang; B Safer; robert kotin
Determination of adeno-associated virus Rep68 and Rep78 binding sites by random sequence oligonucleotide selection.
Journal of virology 1995;69(11):7334-8.
1994: John A Chiorini; S M Wiener; Roland A Owens; S R Kyöstió; robert kotin; B Safer
Sequence requirements for stable binding and function of Rep68 on the adeno-associated virus type 2 inverted terminal repeats.
Journal of virology 1994;68(11):7448-57.
1994: B J Efiok; John A Chiorini; B Safer
A key transcription factor for eukaryotic initiation factor-2 alpha is strongly homologous to developmental transcription factors and may link metabolic genes to cellular growth and development.
The Journal of biological chemistry 1994;269(29):18921-30.
1994: John A Chiorini; M D Weitzman; Roland A Owens; E Urcelay; B Safer; robert kotin
Biologically active Rep proteins of adeno-associated virus type 2 produced as fusion proteins in Escherichia coli.
Journal of virology 1994;68(2):797-804.
1993: John A Chiorini; Thomas Boal; S Miyamoto; B Safer
A difference in the rate of ribosomal elongation balances the synthesis of eukaryotic translation initiation factor (eIF)-2 alpha and eIF-2 beta.
The Journal of biological chemistry 1993;268(18):13748-55.
1993: Thomas Boal; John A Chiorini; R B Cohen; S Miyamoto; R M Frederickson; N Sonenberg; B Safer
Regulation of eukaryotic translation initiation factor expression during T-cell activation.
Biochimica et biophysica acta 1993;1176(3):257-64.
1989: M Hümbelin; B Safer; John A Chiorini; John W B Hershey; R B Cohen
Isolation and characterization of the promoter and flanking regions of the gene encoding the human protein-synthesis-initiation factor 2 alpha.
Gene 1989;81(2):315-24.