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Gabriela Chiosis

Research Profile

Chemicals & Drugs

Anatomy

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Drug Design

Disorders

Genes & Molecular Sequences

Molecular Structure

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Mouse

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Drug Screening Assays, Antitumor

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Publications

TOP 3
Lucia Lisi; Susan McGuire; Pierluigi Navarra; Anthony Sharp; Gabriela Chiosis; Douglas L Feinstein; Cinzia Dello Russo
The novel HSP90 inhibitor, PU-H71, suppresses glial cell activation but weakly affects clinical signs of EAE.
Tony Taldone; Danuta Zatorska; Raul Alonso-Sabadell; Erica M Dagama Gomes; Sarah Kishinevsky; Hardik J Patel; Maulik R Patel; Matthew Riolo; Anna Rodina; Gabriela Chiosis
Synthesis and evaluation of cell-permeable biotinylated PU-H71 derivatives as tumor Hsp90 probes.
Gabriela Chiosis; Chad A Dickey; Jill L Johnson
A global view of Hsp90 functions.

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All Publications

2013: Lucia Lisi; Susan McGuire; Pierluigi Navarra; Anthony Sharp; Gabriela Chiosis; Douglas L Feinstein; Cinzia Dello Russo
The novel HSP90 inhibitor, PU-H71, suppresses glial cell activation but weakly affects clinical signs of EAE.
Journal of neuroimmunology 2013;255(1-2):1-7.
2013: Tony Taldone; Danuta Zatorska; Raul Alonso-Sabadell; Erica M Dagama Gomes; Sarah Kishinevsky; Hardik J Patel; Maulik R Patel; Matthew Riolo; Anna Rodina; Gabriela Chiosis
Synthesis and evaluation of cell-permeable biotinylated PU-H71 derivatives as tumor Hsp90 probes.
Beilstein journal of organic chemistry 2013;9():544-56.
2013: Gabriela Chiosis; Chad A Dickey; Jill L Johnson
A global view of Hsp90 functions.
Nature structural & molecular biology 2013;20(1):1-4.
2012: Carmel T Chan; Gabriela Chiosis; Ron Geller; Aileen Hoehne; Tarik F Massoud; Ramasamy Paulmurugan; Robert E Reeves; David E Solow-Cordero; Shahriar S Yaghoubi; Sanjiv S Gambhir
Discovery and validation of small-molecule heat-shock protein 90 inhibitors through multimodality molecular imaging in living subjects.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(37):E2476-85.
2012: Priya Koppikar; Laura Leung; Omar Abdel-Wahab; Mazhar Adli; Bradley E Bernstein; Neha Bhagwat; Gabriela Chiosis; Benjamin L Ebert; Zeev Estrov; Aviva Goel; Mithat Gonen; Todd Hricik; Outi Kilpivaara; Fan Liu; Taghi Manshouri; Sachie Marubayashi; Ann Mullally; Stephen D Nimer; Lindsay M Saunders; Srdan Verstovsek; Abby Weinstein; Ross L Levine
Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy.
Nature 2012;489(7414):155-9.
2012: James C Brooks; Gabriela Chiosis; Weilin Sun; Cynthia A Leifer
Heat shock protein gp96 regulates Toll-like receptor 9 proteolytic processing and conformational stability.
Biochemical and biophysical research communications 2012;421(4):780-4.
2012: Ninel Azoitei; Claudia R Ball; Gabriela Chiosis; Hartmut Döhner; Jana M Ellegast; Katrin Faber; Stefan Fröhling; Felicitas Genze; Hanno Glimm; Ulrike Gößele; Christopher M Hoffmann; Hans A Kestler; Britta Koch; Kerstin Obermayer; Mark Schrader; Claudia Scholl
Targeting of KRAS mutant tumors by HSP90 inhibitors involves degradation of STK33.
The Journal of experimental medicine 2012;209(4):697-711.
2012: Komal Jhaveri; Shanu Modi; Tony Taldone; Gabriela Chiosis
Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers.
Biochimica et biophysica acta 2012;1823(3):742-55.
2011: Kamalika Moulick; Len Neckers; Stephen D Nimer; Fabiana Perna; Nagavarakishore Pillarsetty; Anna Rodina; Peter Smith-Jones; Tony Taldone; Ly P Vu; Danuta Zatorska; Xinyang Zhao; Hongliang Zong; Hediye Erdjument-Bromage; Erica M Gomes DaGama; Steven S Gross; Monica L Guzman; Katerina Hatzi; Thomas Ku; Steven M Larson; Ross Levine; Jason S Lewis; Ari Melnick; James H Ahn; Mary Alpaugh; Kristin Beebe; Eloisi Caldas Lopes; Leandro Cerchietti; Gabriela Chiosis
Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90.
Nature chemical biology 2011;7(11):818-26.
2011: Tony Taldone; Danuta Zatorska; Hongliang Zong; Raul Alonso-Sabadell; Mary L Alpaugh; Erica M Gomes-DaGama; Monica L Guzman; Siddhartha Sen; Gabriela Chiosis
Synthesis of purine-scaffold fluorescent probes for heat shock protein 90 with use in flow cytometry and fluorescence microscopy.
Bioorganic & medicinal chemistry letters 2011;21(18):5347-52.
2011: Saad Z Usmani; Gabriela Chiosis
HSP90 inhibitors as therapy for multiple myeloma.
Clinical lymphoma, myeloma & leukemia 2011;11 Suppl 1():S77-81.
2011: James H Ahn; Wenjie Luo; Joungnam Kim; Anna Rodina; Cristina Clement; Julia Aguirre; Weilin Sun; Yanlong Kang; Ronnie Maharaj; Kamalika Moulick; Danuta Zatorska; Malgorzata Kokoszka; Jeffrey L Brodsky; Gabriela Chiosis
Design of a flexible cell-based assay for the evaluation of heat shock protein 70 expression modulators.
Assay and drug development technologies 2011;9(3):236-46.
2011: Tony Taldone; Danuta Zatorska; Pallav D Patel; Hongliang Zong; Anna Rodina; James H Ahn; Kamalika Moulick; Monica L Guzman; Gabriela Chiosis
Design, synthesis, and evaluation of small molecule Hsp90 probes.
Bioorganic & medicinal chemistry 2011;19(8):2603-14.
2011: Marco Breinig; Philipp Mayer; Andreas Harjung; Benjamin Goeppert; Mona Malz; Roland Penzel; Olaf Neumann; Arndt Hartmann; Hendrik Dienemann; Giuseppe Giaccone; Peter Schirmacher; Michael André Kern; Gabriela Chiosis; Ralf Joachim Rieker
Heat shock protein 90-sheltered overexpression of insulin-like growth factor 1 receptor contributes to malignancy of thymic epithelial tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(8):2237-49.
2010: Sachie Marubayashi; Priya Koppikar; Tony Taldone; Omar Abdel-Wahab; Nathan West; Neha Bhagwat; Eloisi Caldas Lopes; Kenneth N Ross; Mithat Gonen; Alex Gozman; James H Ahn; Anna Rodina; Ouathek Ouerfelli; Guangbin Yang; Cyrus V Hedvat; James E Bradner; Gabriela Chiosis; Ross Levine
HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans.
The Journal of clinical investigation 2010;120(10):3578-93.
2010: Iwona E Wrona; Alexander Gozman; Tony Taldone; Gabriela Chiosis; James S Panek
Synthesis of reblastatin, autolytimycin, and non-benzoquinone analogues: potent inhibitors of heat shock protein 90.
The Journal of organic chemistry 2010;75(9):2820-35.
2010: Saad Z Usmani; Robert D Bona; Gabriela Chiosis; Zihai Li
The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1.
Journal of hematology & oncology 2010;3():40.
2010: Tony Taldone; Victoria Gillan; Weilin Sun; Anna Rodina; Pallav Patel; Kirsty Maitland; Kerry O'Neill; Gabriela Chiosis; Eileen Devaney
Assay strategies for the discovery and validation of therapeutics targeting Brugia pahangi Hsp90.
PLoS neglected tropical diseases 2010;4(6):e714.
2010: Wenjie Luo; Weilin Sun; Tony Taldone; Anna Rodina; Gabriela Chiosis
Heat shock protein 90 in neurodegenerative diseases.
Molecular neurodegeneration 2010;5():24.
2010: Jason P Holland; Eloisi Caldas Lopes; Vadim Divilov; Valerie A Longo; Tony Taldone; Danuta Zatorska; Gabriela Chiosis; Jason S Lewis
Measuring the pharmacodynamic effects of a novel Hsp90 inhibitor on HER2/neu expression in mice using Zr-DFO-trastuzumab.
PloS one 2010;5(1):e8859.
2009: Leandro Cerchietti; Eloisi C Lopes; Shao Ning Yang; Katerina Hatzi; Karen L Bunting; Lucas A Tsikitas; Alka Mallik; Ana I Robles; Jennifer Walling; Lyuba Varticovski; Rita Shaknovich; Kapil N Bhalla; Gabriela Chiosis; Ari Melnick
A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6-dependent B cell lymphomas.
Nature medicine 2009;15(12):1369-76.
2009: Marco Breinig; Eloisi Caldas Lopes; Benjamin Goeppert; Mona Malz; Ralf Rieker; Frank Bergmann; Peter Schirmacher; Matthias Mayer; Gabriela Chiosis; Michael A Kern
Targeting heat shock protein 90 with non-quinone inhibitors: a novel chemotherapeutic approach in human hepatocellular carcinoma.
Hepatology (Baltimore, Md.) 2009;50(1):102-12.
2009: Eloisi Caldas Lopes; Leandro Cerchietti; James H Ahn; Cristina Clement; Ana I Robles; Anna Rodina; Kamalika Moulick; Tony Taldone; Alexander Gozman; Yunke Guo; Nian Wu; Elisa de Stanchina; Julie White; Steven S Gross; Yuliang Ma; Lyuba Varticovski; Ari Melnick; Gabriela Chiosis
Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(20):8368-73.
2009: Tony Taldone; Weilin Sun; Gabriela Chiosis
Discovery and development of heat shock protein 90 inhibitors.
Bioorganic & medicinal chemistry 2009;17(6):2225-35.
2009: Hui Tao; Yanlong Kang; Tony Taldone; Gabriela Chiosis
Microwave-assisted one step synthesis of 8-arylmethyl-9H-purin-6-amines.
Bioorganic & medicinal chemistry letters 2009;19(2):415-7.
2009: Tony Taldone; Gabriela Chiosis
Purine-scaffold Hsp90 inhibitors.
Current topics in medicinal chemistry 2009;9(15):1436-46.
2009: Gabriela Chiosis; Adam B Keeton
Assay for isolation of inhibitors of her2-kinase expression.
Methods in molecular biology (Clifton, N.J.) 2009;486():139-49.
2008: Eloisi C Lopes; Ester Valls; Maria E Figueroa; Alexander Mazur; Fan-Guo Meng; Gabriela Chiosis; Peter W Laird; Nicole Schreiber-Agus; John M Greally; Egor Prokhortchouk; Ari Melnick
Kaiso contributes to DNA methylation-dependent silencing of tumor suppressor genes in colon cancer cell lines.
Cancer research 2008;68(18):7258-63.
2008: Tony Taldone; Alexander Gozman; Ronnie Maharaj; Gabriela Chiosis
Targeting Hsp90: small-molecule inhibitors and their clinical development.
Current opinion in pharmacology 2008;8(4):370-4.
2008: Thota Ganesh; Jaeki Min; Pahk Thepchatri; Yuhong Du; Lian Li; Iestyn Lewis; Larry Wilson; Haian Fu; Gabriela Chiosis; ray dingledine; Dennis C Liotta; James P Snyder; Aiming Sun
Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling.
Bioorganic & medicinal chemistry 2008;16(14):6903-10.
2008: Jennifer L Goeckeler; Anthony P Petruso; Julia Aguirre; Cristina Clement; Gabriela Chiosis; Jeffrey L Brodsky
The yeast Hsp110, Sse1p, exhibits high-affinity peptide binding.
FEBS letters 2008;582(16):2393-6.
2008: Yanlong Kang; Tony Taldone; Cristina Clement; Sheara W Fewell; Julia Aguirre; Jeffrey L Brodsky; Gabriela Chiosis
Design of a fluorescence polarization assay platform for the study of human Hsp70.
Bioorganic & medicinal chemistry letters 2008;18(13):3749-51.
2008: C Didelot; D Lanneau; M Brunet; A Bouchot; J Cartier; A Jacquel; P Ducoroy; S Cathelin; N Decologne; Gabriela Chiosis; L Dubrez-Daloz; E Solary; C Garrido
Interaction of heat-shock protein 90 beta isoform (HSP90 beta) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiation.
Cell death and differentiation 2008;15(5):859-66.
2008: Lizhen Wang; Chengsong Xie; Elisa Greggio; Loukia Parisiadou; Hoon Shim; Lixin Sun; Jayanth Chandran; Xian Lin; Chen Lai; Wan-Jou Yang; Darren J Moore; Ted M Dawson; Valina Dawson; Gabriela Chiosis; Mark Cookson; Huaibin Cai
The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(13):3384-91.
2008: Gabriela Chiosis; Yanlong Kang; Weilin Sun
Discovery and development of purine-scaffold Hsp90 inhibitors.
Expert opinion on drug discovery 2008;3(1):99-114.
2008: Wenjie Luo; Anna Rodina; Gabriela Chiosis
Heat shock protein 90: translation from cancer to Alzheimer's disease treatment?
BMC neuroscience 2008;9 Suppl 2():S7.
2008: David B Solit; Gabriela Chiosis
Development and application of Hsp90 inhibitors.
Drug discovery today 2008;13(1-2):38-43.
2008: Carmel T Chan; Ramasamy Paulmurugan; Olivier Gheysens; Joungnam Kim; Gabriela Chiosis; Sanjiv S Gambhir
Molecular imaging of the efficacy of heat shock protein 90 inhibitors in living subjects.
Cancer research 2008;68(1):216-26.
2007: Yuhong Du; Kamalika Moulick; Anna Rodina; Julia Aguirre; Sara Felts; ray dingledine; Haian Fu; Gabriela Chiosis
High-throughput screening fluorescence polarization assay for tumor-specific Hsp90.
Journal of biomolecular screening 2007;12(7):915-24.
2007: Anna Rodina; Maria Vilenchik; Kamalika Moulick; Julia Aguirre; Joungnam Kim; Anne Chiang; Julie Litz; Cristina Clement; Yanlong Kang; Yuhong She; Nian Wu; Sara Felts; Peter Wipf; Joan Massague; Xuejun Jiang; Jeffrey L Brodsky; Geoffrey W Krystal; Gabriela Chiosis
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.
Nature chemical biology 2007;3(8):498-507.
2007: Wenjie Luo; Fei Dou; Anna Rodina; Sophorn Chip; Joungnam Kim; Qi Zhao; Kamalika Moulick; Julia Aguirre; Nian Wu; Paul Greengard; Gabriela Chiosis
Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(22):9511-6.
2007: Celine Didelot; David Lanneau; Mathilde Brunet; Anne-Laure Joly; Aurelie De Thonel; Gabriela Chiosis; Carmen Garrido
Anti-cancer therapeutic approaches based on intracellular and extracellular heat shock proteins.
Current medicinal chemistry 2007;14(27):2839-47.
2006: Gabriela Chiosis; Hui Tao
Purine-scaffold Hsp90 inhibitors.
IDrugs : the investigational drugs journal 2006;9(11):778-82.
2006: Haley Hieronymus; Justin Lamb; Kenneth N Ross; Xiao P Peng; Cristina Clement; Anna Rodina; Maria Nieto; Jinyan Du; Kimberly Stegmaier; Srilakshmi M Raj; Katherine N Maloney; Jon Clardy; William C Hahn; Gabriela Chiosis; Todd R Golub
Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators.
Cancer cell 2006;10(4):321-30.
2006: Kamalika Moulick; Cristina Clement; Julia Aguirre; Joungnam Kim; Yanlong Kang; Sara Felts; Gabriela Chiosis
Synthesis of a red-shifted fluorescence polarization probe for Hsp90.
Bioorganic & medicinal chemistry letters 2006;16(17):4515-8.
2006: Robert M Immormino; Yanlong Kang; Gabriela Chiosis; Daniel T Gewirth
Structural and quantum chemical studies of 8-aryl-sulfanyl adenine class Hsp90 inhibitors.
Journal of medicinal chemistry 2006;49(16):4953-60.
2006: Gabriela Chiosis; Julia Aguirre; Christopher V Nicchitta
Synthesis of Hsp90 dimerization modulators.
Bioorganic & medicinal chemistry letters 2006;16(13):3529-32.
2006: Gabriela Chiosis; Len Neckers
Tumor selectivity of Hsp90 inhibitors: the explanation remains elusive.
ACS chemical biology 2006;1(5):279-84.
2006: Gabriela Chiosis; Eloisi Caldas Lopes; David B Solit
Heat shock protein-90 inhibitors: a chronicle from geldanamycin to today's agents.
Current opinion in investigational drugs (London, England : 2000) 2006;7(6):534-41.
2006: Feixia Chu; Jason C Maynard; Gabriela Chiosis; Christopher V Nicchitta; Al L Burlingame
Identification of novel quaternary domain interactions in the Hsp90 chaperone, GRP94.
Protein science : a publication of the Protein Society 2006;15(6):1260-9.
2006: Gabriella De Martino; Michael Edler; Giuseppe La Regina; Antonio Coluccia; Maria Chiara Barbera; Denise Barrow; Robert I Nicholson; Gabriela Chiosis; Andrea Brancale; Ernest Hamel; Marino Artico; Romano Silvestri
New arylthioindoles: potent inhibitors of tubulin polymerization. 2. Structure-activity relationships and molecular modeling studies.
Journal of medicinal chemistry 2006;49(3):947-54.
2006: Gabriela Chiosis
Targeting chaperones in transformed systems--a focus on Hsp90 and cancer.
Expert opinion on therapeutic targets 2006;10(1):37-50.
2006: Huazhong He; Danuta Zatorska; Joungnam Kim; Julia Aguirre; Laura Llauger; Yuhong She; Nian Wu; Robert M Immormino; Daniel T Gewirth; Gabriela Chiosis
Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90.
Journal of medicinal chemistry 2006;49(1):381-90.
2006: Jeffrey L Brodsky; Gabriela Chiosis
Hsp70 molecular chaperones: emerging roles in human disease and identification of small molecule modulators.
Current topics in medicinal chemistry 2006;6(11):1215-25.
2006: Gabriela Chiosis
Discovery and development of purine-scaffold Hsp90 inhibitors.
Current topics in medicinal chemistry 2006;6(11):1183-91.
2006: Gabriela Chiosis; Anna Rodina; Kamalika Moulick
Emerging Hsp90 inhibitors: from discovery to clinic.
Anti-cancer agents in medicinal chemistry 2006;6(1):1-8.
2005: Gabriela Chiosis; Jeffrey L Brodsky
Small molecule microarrays: from proteins to mammalian cells - are we there yet?
Trends in biotechnology 2005;23(6):271-4.
2005: Laura Llauger; Huazhong He; Joungnam Kim; Julia Aguirre; Neal Rosen; Ulf Peters; Peter Davies; Gabriela Chiosis
Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90.
Journal of medicinal chemistry 2005;48(8):2892-905.
2004: Gabriela Chiosis; Maria Vilenchik; Joungnam Kim; David B Solit
Hsp90: the vulnerable chaperone.
Drug discovery today 2004;9(20):881-8.
2004: Joungnam Kim; Sara Felts; Laura Llauger; Huazhong He; Henri Huezo; Neal Rosen; Gabriela Chiosis
Development of a fluorescence polarization assay for the molecular chaperone Hsp90.
Journal of biomolecular screening 2004;9(5):375-81.
2004: Maria Vilenchik; David B Solit; Andrea Basso; Henri Huezo; Brian Lucas; Huazhong He; Neal Rosen; Claudia Spampinato; Paul Modrich; Gabriela Chiosis
Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90.
Chemistry & biology 2004;11(6):787-97.
2004: Huazhong He; Laura Llauger; Neal Rosen; Gabriela Chiosis
General method for the synthesis of 8-arylsulfanyl adenine derivatives.
The Journal of organic chemistry 2004;69(9):3230-2.
2003: Laura Llauger-Bufi; Sara Felts; Henri Huezo; Neal Rosen; Gabriela Chiosis
Synthesis of novel fluorescent probes for the molecular chaperone Hsp90.
Bioorganic & medicinal chemistry letters 2003;13(22):3975-8.
2003: Gabriela Chiosis; Brian Lucas; Henri Huezo; David B Solit; Andrea Basso; Neal Rosen
Development of purine-scaffold small molecule inhibitors of Hsp90.
Current cancer drug targets 2003;3(5):371-6.
2003: Henri Huezo; Maria Vilenchik; Neal Rosen; Gabriela Chiosis
Microtiter cell-based assay for detection of agents that alter cellular levels of Her2 and EGFR.
Chemistry & biology 2003;10(7):629-34.
2003: Ivo G Boneca; Gabriela Chiosis
Vancomycin resistance: occurrence, mechanisms and strategies to combat it.
Expert opinion on therapeutic targets 2003;7(3):311-28.
2003: Kana Yamamoto; Robert M Garbaccio; Shawn J Stachel; David B Solit; Gabriela Chiosis; Neal Rosen; Samuel J Danishefsky
Total synthesis as a resource in the discovery of potentially valuable antitumor agents: cycloproparadicicol.
Angewandte Chemie (International ed. in English) 2003;42(11):1280-4.
2003: Gabriela Chiosis; Henri Huezo; Neal Rosen; Edward G Mimnaugh; Luke Whitesell; Len Neckers
17AAG: low target binding affinity and potent cell activity--finding an explanation.
Molecular cancer therapeutics 2003;2(2):123-9.
2002: Gabriela Chiosis; Brian Lucas; Alexander A Shtil; Henri Huezo; Neal Rosen
Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase.
Bioorganic & medicinal chemistry 2002;10(11):3555-64.
2002: Andrea D Basso; David B Solit; Gabriela Chiosis; Banabihari Giri; Philip Tsichlis; Neal Rosen
Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function.
The Journal of biological chemistry 2002;277(42):39858-66.
2002: Mercedes E Gorre; Katharine Ellwood-Yen; Gabriela Chiosis; Neal Rosen; Charles L Sawyers
BCR-ABL point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90.
Blood 2002;100(8):3041-4.
2001: Brian Lucas; Neal Rosen; Gabriela Chiosis
Facile synthesis of a library of 9-alkyl-8-benzyl-9H-purin-6-ylamine derivatives.
Journal of combinatorial chemistry 2001;3(6):518-20.
2001: Gabriela Chiosis; Ivo G Boneca
Selective cleavage of D-Ala-D-Lac by small molecules: re-sensitizing resistant bacteria to vancomycin.
Science (New York, N.Y.) 2001;293(5534):1484-7.
2001: Gabriela Chiosis; Neal Rosen; Laura Sepp-Lorenzino
LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family.
Bioorganic & medicinal chemistry letters 2001;11(7):909-13.
2001: Gabriela Chiosis; M N Timaul; Brian Lucas; Pamela N Munster; Fuzhong F Zheng; Laura Sepp-Lorenzino; Neal Rosen
A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells.
Chemistry & biology 2001;8(3):289-99.
2000: Fuzhong F Zheng; SD Kuduk; Gabriela Chiosis; Pamela N Münster; Laura Sepp-Lorenzino; Samuel J Danishefsky; Neal Rosen
Identification of a geldanamycin dimer that induces the selective degradation of HER-family tyrosine kinases.
Cancer research 2000;60(8):2090-4.