Username

Password

Forgot Password?

Preview

Sign-in free and Explore the Exciting World of BiomedExperts:

Over 1.500.000 Profiles
More than 1.800 Organizations worldwide
State of the Art Network Visualizations

Manage your own Profile
Locate Experts in your Country/Region
Locate Experts in your 1. and 2. Level Network
Connect to Experts Worldwide

NetworkView

Dario Alessi

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Phenomena

Physiology

Genes & Molecular Sequences

Amino Acid Sequence

Concepts & Ideas

Anatomy

Cell Line

Living Beings

Mice
Rats

Sign-in to see full Profile

Network (preview)

Co-Publications
Name
47
Deak, Maria
21
Cohen, Philip
17
van Aalten, Daan
14
Boudeau, Jérôme
12
Morrice, Nick
12
Prescott, Alan
11
Kieloch, Agnieszka
10
Morrice, Nick
9
Casamayor, Antonio
9
Downes, Peter
8
Komander, David
8
Kular, Gursant
8
Sakamoto, Kei
8
Lizcano, Jose
7
Sapkota, Gopal

Sign-in to see all Coauthors

Publications

TOP 3
Nichols R Jeremy; Dzamko Nicolas; Hutti Jessica E; Cantley Lewis C; Deak Maria; Moran Jennifer; Bamborough Paul; Reith Alastair D; Alessi Dario R
Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease.
Libby Gillian; Donnelly Louise A; Donnan Peter T; Alessi Dario R; Morris Andrew D; Evans Josie M M
New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes.
García-Martínez Juan M; Moran Jennifer; Clarke Rosemary G; Gray Alex; Cosulich Sabina C; Chresta Christine M; Alessi Dario R
Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR).

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of Dario Alessi (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2009: Nichols R Jeremy; Dzamko Nicolas; Hutti Jessica E; Cantley Lewis C; Deak Maria; Moran Jennifer; Bamborough Paul; Reith Alastair D; Alessi Dario R
Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease.
The Biochemical journal 2009;424(1):47-60.
2009: Libby Gillian; Donnelly Louise A; Donnan Peter T; Alessi Dario R; Morris Andrew D; Evans Josie M M
New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes.
Diabetes care 2009;32(9):1620-5.
2009: García-Martínez Juan M; Moran Jennifer; Clarke Rosemary G; Gray Alex; Cosulich Sabina C; Chresta Christine M; Alessi Dario R
Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR).
The Biochemical journal 2009;421(1):29-42.
2009: Zeqiraj Elton; Filippi Beatrice Maria; Goldie Simon; Navratilova Iva; Boudeau Jérôme; Deak Maria; Alessi Dario R; van Aalten Daan M F
ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor.
PLoS biology 2009;7(6):e1000126.
2009: San-Cristobal Pedro; Pacheco-Alvarez Diana; Richardson Ciaran; Ring Aaron M; Vazquez Norma; Rafiqi Fatema H; Chari Divya; Kahle Kristopher T; Leng Qiang; Bobadilla Norma A; Hebert Steven C; Alessi Dario R; Lifton Richard P; Gamba Gerardo
Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(11):4384-9.
2009: Peifer Christian; Alessi Dario R
New anti-cancer role for PDK1 inhibitors: preventing resistance to tamoxifen.
The Biochemical journal 2009;417(1):e5-7.
2009: Boini Krishna M; Amann Kerstin; Kempe Daniela; Alessi Dario R; Lang Florian
Proteinuria in mice expressing PKB/SGK-resistant GSK3.
American journal of physiology. Renal physiology 2009;296(1):F153-9.
2009: Alessi Dario R; Pearce Laura R; García-Martínez Juan M
New insights into mTOR signaling: mTORC2 and beyond.
Science signaling 2009;2(67):pe27.
2008: García-Martínez Juan M; Alessi Dario R
mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1).
The Biochemical journal 2008;416(3):375-85.
2008: Villa Fabrizio; Deak Maria; Alessi Dario R; van Aalten Daan M F
Structure of the OSR1 kinase, a hypertension drug target.
Proteins 2008;73(4):1082-7.
2008: Richardson Ciaran; Alessi Dario R
The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway.
Journal of cell science 2008;121(Pt 20):3293-304.
2008: Filippi Beatrice Maria; Alessi Dario R
Novel role for the LKB1 pathway in controlling monocarboxylate fuel transporters.
The Journal of cell biology 2008;183(1):7-9.
2008: Green Charlotte J; Göransson Olga; Kular Gursant S; Leslie Nick R; Gray Alexander; Alessi Dario R; Sakamoto Kei; Hundal Harinder S
Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake.
The Journal of biological chemistry 2008;283(41):27653-67.
2008: De Sarno Patrizia; Axtell Robert C; Raman Chander; Roth Kevin A; Alessi Dario R; Jope Richard S
Lithium prevents and ameliorates experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(1):338-45.
2008: Huang Xu; Wullschleger Stephan; Shpiro Natalia; McGuire Victoria A; Sakamoto Kei; Woods Yvonne L; McBurnie Wendy; Fleming Stewart; Alessi Dario R
Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice.
The Biochemical journal 2008;412(2):211-21.
2008: Bayascas Jose R; Wullschleger Stephan; Sakamoto Kei; García-Martínez Juan M; Clacher Carol; Komander David; van Aalten Daan M F; Boini Krishna M; Lang Florian; Lipina Christopher; Logie Lisa; Sutherland Calum; Chudek John A; van Diepen Janna A; Voshol Peter J; Lucocq John M; Alessi Dario R
Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance.
Molecular and cellular biology 2008;28(10):3258-72.
2008: Al-Hakim Abdallah K; Zagorska Anna; Chapman Louise; Deak Maria; Peggie Mark; Alessi Dario R
Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains.
The Biochemical journal 2008;411(2):249-60.
2008: Richardson Ciaran; Rafiqi Fatema H; Karlsson Håkan K R; Moleleki Ntsane; Vandewalle Alain; Campbell David G; Morrice Nick A; Alessi Dario R
Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1.
Journal of cell science 2008;121(Pt 5):675-84.
2007: Bain Jenny; Plater Lorna; Elliott Matt; Shpiro Natalia; Hastie C James; McLauchlan Hilary; Klevernic Iva; Arthur J Simon C; Alessi Dario R; Cohen Philip
The selectivity of protein kinase inhibitors: a further update.
The Biochemical journal 2007;408(3):297-315.
2007: Villa Fabrizio; Goebel Jürgen; Rafiqi Fatema H; Deak Maria; Thastrup Jacob; Alessi Dario R; van Aalten Daan M F
Structural insights into the recognition of substrates and activators by the OSR1 kinase.
EMBO reports 2007;8(9):839-45.
2007: Logie Lisa; Ruiz-Alcaraz Antonio J; Keane Michael; Woods Yvonne L; Bain Jennifer; Marquez Rudolfo; Alessi Dario R; Sutherland Calum
Characterization of a protein kinase B inhibitor in vitro and in insulin-treated liver cells.
Diabetes 2007;56(9):2218-27.
2007: Pearce Laura R; Huang Xu; Boudeau Jérôme; Pawlowski Rafal; Wullschleger Stephan; Deak Maria; Ibrahim Adel F M; Gourlay Robert; Magnuson Mark A; Alessi Dario R
Identification of Protor as a novel Rictor-binding component of mTOR complex-2.
The Biochemical journal 2007;405(3):513-22.
2007: Jaleel Mahaboobi; Nichols R Jeremy; Deak Maria; Campbell David G; Gillardon Frank; Knebel Axel; Alessi Dario R
LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity.
The Biochemical journal 2007;405(2):307-17.
2007: Zagórska Anna; Pozo-Guisado Eulalia; Boudeau Jérôme; Vitari Alberto C; Rafiqi Fatema H; Thastrup Jacob; Deak Maria; Campbell David G; Morrice Nick A; Prescott Alan R; Alessi Dario R
Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress.
The Journal of cell biology 2007;176(1):89-100.
2007: Sapkota Gopal P; Cummings Lorna; Newell Felicity S; Armstrong Christopher; Bain Jennifer; Frodin Morten; Grauert Matthias; Hoffmann Matthias; Schnapp Gisela; Steegmaier Martin; Cohen Philip; Alessi Dario R
BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo.
The Biochemical journal 2007;401(1):29-38.
2006: Budas Grant R; Sukhodub Andrey; Alessi Dario R; Jovanovic Aleksandar
3'Phosphoinositide-dependent kinase-1 is essential for ischemic preconditioning of the myocardium.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(14):2556-8.
2006: Rexhepaj Rexhep; Grahammer Florian; Völkl Harald; Remy Christine; Wagner Carsten A; Sandulache Diana; Artunc Ferruh; Henke Guido; Nammi Srinivas; Capasso Giovambattista; Alessi Dario R; Lang Florian
Reduced intestinal and renal amino acid transport in PDK1 hypomorphic mice.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(13):2214-22.
2006: Sandu Ciprian; Artunc Ferruh; Palmada Monica; Rexhepaj Rexhep; Grahammer Florian; Hussain Azeemudeen; Yun Chris; Alessi Dario R; Lang Florian
Impaired intestinal NHE3 activity in the PDK1 hypomorphic mouse.
American journal of physiology. Gastrointestinal and liver physiology 2006;291(5):G868-76.
2006: Artunc Ferruh; Rexhepaj Rexhep; Völkl Harald; Grahammer Florian; Remy Christine; Sandulache Diana; Nasir Omaima; Wagner Carsten A; Alessi Dario R; Lang Florian
Impaired intestinal and renal glucose transport in PDK-1 hypomorphic mice.
American journal of physiology. Regulatory, integrative and comparative physiology 2006;291(5):R1533-8.
2006: Göransson Olga; Deak Maria; Wullschleger Stephan; Morrice Nick A; Prescott Alan R; Alessi Dario R
Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation.
Journal of cell science 2006;119(Pt 19):4059-70.
2006: Bayascas Jose R; Sakamoto Kei; Armit Laura; Arthur J Simon C; Alessi Dario R
Evaluation of approaches to generation of tissue-specific knock-in mice.
The Journal of biological chemistry 2006;281(39):28772-81.
2006: Boudeau Jérôme; Miranda-Saavedra Diego; Barton Geoffrey J; Alessi Dario R
Emerging roles of pseudokinases.
Trends in cell biology 2006;16(9):443-52.
2006: Vitari Alberto C; Thastrup Jacob; Rafiqi Fatema H; Deak Maria; Morrice Nick A; Karlsson Håkan K R; Alessi Dario R
Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.
The Biochemical journal 2006;397(1):223-31.
2006: Sakamoto Kei; Zarrinpashneh Elham; Budas Grant R; Pouleur Anne-Catherine; Dutta Anindya; Prescott Alan R; Vanoverschelde Jean-Louis; Ashworth Alan; Jovanovic Aleksandar; Alessi Dario R; Bertrand Luc
Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1.
American journal of physiology. Endocrinology and metabolism 2006;290(5):E780-8.
2006: Jaleel Mahaboobi; Villa Fabrizio; Deak Maria; Toth Rachel; Prescott Alan R; Van Aalten Daan M F; Alessi Dario R
The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation.
The Biochemical journal 2006;394(Pt 3):545-55.
2006: Alessi Dario R; Sakamoto Kei; Bayascas Jose R
LKB1-dependent signaling pathways.
Annual review of biochemistry 2006;75():137-63.
2005: Al-Hakim Abdallah K; Göransson Olga; Deak Maria; Toth Rachel; Campbell David G; Morrice Nick A; Prescott Alan R; Alessi Dario R
14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.
Journal of cell science 2005;118(Pt 23):5661-73.
2005: Lipina Christopher; Huang Xu; Finlay David; McManus Edward J; Alessi Dario R; Sutherland Calum
Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3.
The Biochemical journal 2005;392(Pt 3):633-9.
2005: Collins Barry J; Deak Maria; Murray-Tait Vicky; Storey Kate G; Alessi Dario R
In vivo role of the phosphate groove of PDK1 defined by knockin mutation.
Journal of cell science 2005;118(Pt 21):5023-34.
2005: Bayascas Jose R; Leslie Nick R; Parsons Ramon; Fleming Stewart; Alessi Dario R
Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice.
Current biology : CB 2005;15(20):1839-46.
2005: Vitari Alberto C; Deak Maria; Morrice Nick A; Alessi Dario R
The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases.
The Biochemical journal 2005;391(Pt 1):17-24.
2005: Mora Alfonso; Sakamoto Kei; McManus Edward J; Alessi Dario R
Role of the PDK1-PKB-GSK3 pathway in regulating glycogen synthase and glucose uptake in the heart.
FEBS letters 2005;579(17):3632-8.
2005: Evans Josie M M; Donnelly Louise A; Emslie-Smith Alistair M; Alessi Dario R; Morris Andrew D
Metformin and reduced risk of cancer in diabetic patients.
BMJ (Clinical research ed.) 2005;330(7503):1304-5.
2005: Sakamoto Kei; McCarthy Afshan; Smith Darrin; Green Kevin A; Grahame Hardie D; Ashworth Alan; Alessi Dario R
Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction.
The EMBO journal 2005;24(10):1810-20.
2005: Komander David; Kular Gursant; Deak Maria; Alessi Dario R; van Aalten Daan M F
Role of T-loop phosphorylation in PDK1 activation, stability, and substrate binding.
The Journal of biological chemistry 2005;280(19):18797-802.
2005: Bayascas Jose R; Alessi Dario R
Regulation of Akt/PKB Ser473 phosphorylation.
Molecular cell 2005;18(2):143-5.
2005: McManus Edward J; Sakamoto Kei; Armit Laura J; Ronaldson Leah; Shpiro Natalia; Marquez Rodolfo; Alessi Dario R
Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis.
The EMBO journal 2005;24(8):1571-83.
2005: Dümmler Bettina A; Hauge Camilla; Silber Joachim; Yntema Helger G; Kruse Lars S; Kofoed Birte; Hemmings Brian A; Alessi Dario R; Frödin Morten
Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell types.
The Journal of biological chemistry 2005;280(14):13304-14.
2005: Villa Fabrizio; Deak Maria; Bloomberg Graham B; Alessi Dario R; van Aalten Daan M F
Crystal structure of the PTPL1/FAP-1 human tyrosine phosphatase mutated in colorectal cancer: evidence for a second phosphotyrosine substrate recognition pocket.
The Journal of biological chemistry 2005;280(9):8180-7.
2005: Jaleel Mahaboobi; McBride Andrew; Lizcano Jose M; Deak Maria; Toth Rachel; Morrice Nick A; Alessi Dario R
Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate.
FEBS letters 2005;579(6):1417-23.
2005: Mora Alfonso; Lipina Christopher; Tronche François; Sutherland Calum; Alessi Dario R
Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure.
The Biochemical journal 2005;385(Pt 3):639-48.
2004: Boudeau Jérôme; Scott John W; Resta Nicoletta; Deak Maria; Kieloch Agnieszka; Komander David; Hardie D Grahame; Prescott Alan R; van Aalten Daan M F; Alessi Dario R
Analysis of the LKB1-STRAD-MO25 complex.
Journal of cell science 2004;117(Pt 26):6365-75.
2004: Komander David; Fairservice Alison; Deak Maria; Kular Gursant S; Prescott Alan R; Peter Downes C; Safrany Stephen T; Alessi Dario R; van Aalten Daan M F
Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates.
The EMBO journal 2004;23(20):3918-28.
2004: Sakamoto Kei; Göransson Olga; Hardie D Grahame; Alessi Dario R
Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR.
American journal of physiology. Endocrinology and metabolism 2004;287(2):E310-7.
2004: Schutkowski Mike; Reimer Ulf; Panse Sören; Dong Liying; Lizcano Jose M; Alessi Dario R; Schneider-Mergener Jens
High-content peptide microarrays for deciphering kinase specificity and biology.
Angewandte Chemie (International ed. in English) 2004;43(20):2671-4.
2004: McManus Edward J; Collins Barry J; Ashby Peter R; Prescott Alan R; Murray-Tait Victoria; Armit Laura J; Arthur J Simon C; Alessi Dario R
The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation.
The EMBO journal 2004;23(10):2071-82.
2004: Godi Anna; Di Campli Antonella; Konstantakopoulos Athanasios; Di Tullio Giuseppe; Alessi Dario R; Kular Gursant S; Daniele Tiziana; Marra Pierfrancesco; Lucocq John M; De Matteis M Antonietta
FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P.
Nature cell biology 2004;6(5):393-404.
2004: Hinton Heather J; Alessi Dario R; Cantrell Doreen A
The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development.
Nature immunology 2004;5(5):539-45.
2004: Mora Alfonso; Komander David; van Aalten Daan M F; Alessi Dario R
PDK1, the master regulator of AGC kinase signal transduction.
Seminars in cell & developmental biology 2004;15(2):161-70.
2004: Lizcano Jose M; Göransson Olga; Toth Rachel; Deak Maria; Morrice Nick A; Boudeau Jérôme; Hawley Simon A; Udd Lina; Mäkelä Tomi P; Hardie D Grahame; Alessi Dario R
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.
The EMBO journal 2004;23(4):833-43.
2004: Komander David; Kular Gursant S; Schüttelkopf Alexander W; Deak Maria; Prakash K R C; Bain Jennifer; Elliott Matthew; Garrido-Franco Marta; Kozikowski Alan P; Alessi Dario R; van Aalten Daan M F
Interactions of LY333531 and other bisindolyl maleimide inhibitors with PDK1.
Structure (London, England : 1993) 2004;12(2):215-26.
2004: Milburn Christine C; Boudeau Jérôme; Deak Maria; Alessi Dario R; van Aalten Daan M F
Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor.
Nature structural & molecular biology 2004;11(2):193-200.
2004: Vitari Alberto C; Deak Maria; Collins Barry J; Morrice Nick; Prescott Alan R; Phelan Anne; Humphreys Sian; Alessi Dario R
WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate.
The Biochemical journal 2004;378(Pt 1):257-68.
2004: McManus Edward J; Alessi Dario R
Cancer, oncogenes and signal transduction.
Genome biology 2004;5(7):332.
2003: Kimber Wendy A; Deak Maria; Prescott Alan R; Alessi Dario R
Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1.
The Biochemical journal 2003;376(Pt 2):525-35.
2003: Milburn Christine C; Deak Maria; Kelly Sharon M; Price Nick C; Alessi Dario R; Van Aalten Daan M F
Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change.
The Biochemical journal 2003;375(Pt 3):531-8.
2003: Boudeau Jérôme; Baas Annette F; Deak Maria; Morrice Nick A; Kieloch Agnieszka; Schutkowski Mike; Prescott Alan R; Clevers Hans C; Alessi Dario R
MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm.
The EMBO journal 2003;22(19):5102-14.
2003: Komander David; Kular Gursant S; Bain Jennifer; Elliott Matthew; Alessi Dario R; Van Aalten Daan M F
Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition.
The Biochemical journal 2003;375(Pt 2):255-62.
2003: Mora Alfonso; Davies Anthony M; Bertrand Luc; Sharif Isam; Budas Grant R; Jovanovic Sofija; Mouton Véronique; Kahn C Ronald; Lucocq John M; Gray Gillian A; Jovanovic Aleksandar; Alessi Dario R
Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia.
The EMBO journal 2003;22(18):4666-76.
2003: Lizcano Jose M; Alrubaie Saif; Kieloch Agnieszka; Deak Maria; Leevers Sally J; Alessi Dario R
Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B.
The Biochemical journal 2003;374(Pt 2):297-306.
2003: Collins Barry J; Deak Maria; Arthur J Simon C; Armit Laura J; Alessi Dario R
In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation.
The EMBO journal 2003;22(16):4202-11.
2003: Boudeau Jérôme; Sapkota Gopal; Alessi Dario R
LKB1, a protein kinase regulating cell proliferation and polarity.
FEBS letters 2003;546(1):159-65.
2003: Baas A F; Boudeau J; Sapkota G P; Smit L; Medema R; Morrice N A; Alessi D R; Clevers H C
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD.
The EMBO journal 2003;22(12):3062-72.
2003: Greene Michael W; Sakaue Hiroshi; Wang Lihong; Alessi Dario R; Roth Richard A
Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation.
The Journal of biological chemistry 2003;278(10):8199-211.
2003: Boudeau Jérôme; Deak Maria; Lawlor Margaret A; Morrice Nick A; Alessi Dario R
Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability.
The Biochemical journal 2003;370(Pt 3):849-57.
2003: Boudeau J; Kieloch A; Alessi D R; Stella A; Guanti G; Resta N
Functional analysis of LKB1/STK11 mutants and two aberrant isoforms found in Peutz-Jeghers Syndrome patients.
Human mutation 2003;21(2):172.
2003: Hawley Simon A; Boudeau Jérôme; Reid Jennifer L; Mustard Kirsty J; Udd Lina; Mäkelä Tomi P; Alessi Dario R; Hardie D Grahame
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade.
Journal of biology 2003;2(4):28.
2002: Sapkota Gopal P; Deak Maria; Kieloch Agnieszka; Morrice Nick; Goodarzi Aaron A; Smythe Carl; Shiloh Yosef; Lees-Miller Susan P; Alessi Dario R
Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366.
The Biochemical journal 2002;368(Pt 2):507-16.
2002: Hamm Jorg; Alessi Dario R; Biondi Ricardo M
Bi-functional, substrate mimicking RNA inhibits MSK1-mediated cAMP-response element-binding protein phosphorylation and reveals magnesium ion-dependent conformational changes of the kinase.
The Journal of biological chemistry 2002;277(48):45793-802.
2002: Douglas Pauline; Sapkota Gopal P; Morrice Nick; Yu Yaping; Goodarzi Aaron A; Merkle Dennis; Meek Katheryn; Alessi Dario R; Lees-Miller Susan P
Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase.
The Biochemical journal 2002;368(Pt 1):243-51.
2002: Zhang Hui; Zha Xiangming; Tan Yi; Hornbeck Peter V; Mastrangelo Allison J; Alessi Dario R; Polakiewicz Roberto D; Comb Michael J
Phosphoprotein analysis using antibodies broadly reactive against phosphorylated motifs.
The Journal of biological chemistry 2002;277(42):39379-87.
2002: McManus Edward J; Alessi Dario R
TSC1-TSC2: a complex tale of PKB-mediated S6K regulation.
Nature cell biology 2002;4(9):E214-6.
2002: Biondi Ricardo M; Komander David; Thomas Christine C; Lizcano Jose M; Deak Maria; Alessi Dario R; van Aalten Daan M F
High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site.
The EMBO journal 2002;21(16):4219-28.
2002: Lizcano Jose M; Deak Maria; Morrice Nick; Kieloch Agnieszka; Hastie C James; Dong Liying; Schutkowski Mike; Reimer Ulf; Alessi Dario R
Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo.
The Journal of biological chemistry 2002;277(31):27839-49.
2002: Thomas Christine C; Deak Maria; Alessi Dario R; van Aalten Daan M F
High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate.
Current biology : CB 2002;12(14):1256-62.
2002: Lawlor Margaret A; Mora Alfonso; Ashby Peter R; Williams Michayla R; Murray-Tait Victoria; Malone Lorraine; Prescott Alan R; Lucocq John M; Alessi Dario R
Essential role of PDK1 in regulating cell size and development in mice.
The EMBO journal 2002;21(14):3728-38.
2002: Dowler Simon; Kular Gursant; Alessi Dario R
Protein lipid overlay assay.
Science's STKE : signal transduction knowledge environment 2002;2002(129):pl6.
2002: Lizcano Jose M; Alessi Dario R
The insulin signalling pathway.
Current biology : CB 2002;12(7):R236-8.
2002: Sapkota Gopal P; Boudeau Jérôme; Deak Maria; Kieloch Agnieszka; Morrice Nick; Alessi Dario R
Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome.
The Biochemical journal 2002;362(Pt 2):481-90.
2002: Kimber Wendy A; Trinkle-Mulcahy Laura; Cheung Peter C F; Deak Maria; Marsden Louisa J; Kieloch Agnieszka; Watt Stephen; Javier Ronald T; Gray Alex; Downes C Peter; Lucocq John M; Alessi Dario R
Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo.
The Biochemical journal 2002;361(Pt 3):525-36.
2001: Thomas C C; Dowler S; Deak M; Alessi D R; van Aalten D M
Crystal structure of the phosphatidylinositol 3,4-bisphosphate-binding pleckstrin homology (PH) domain of tandem PH-domain-containing protein 1 (TAPP1): molecular basis of lipid specificity.
The Biochemical journal 2001;358(Pt 2):287-94.
2001: Leslie N R; Biondi R M; Alessi D R
Phosphoinositide-regulated kinases and phosphoinositide phosphatases.
Chemical reviews 2001;101(8):2365-80.
2001: Lawlor M A; Alessi D R
PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?
Journal of cell science 2001;114(Pt 16):2903-10.
2001: Biondi R M; Kieloch A; Currie R A; Deak M; Alessi D R
The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.
The EMBO journal 2001;20(16):4380-90.
2001: Wang X; Li W; Williams M; Terada N; Alessi D R; Proud C G
Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.
The EMBO journal 2001;20(16):4370-9.
2001: Mora A; Sabio G; González-Polo R A; Cuenda A; Alessi D R; Alonso J C; Fuentes J M; Soler G; Centeno F
Lithium inhibits caspase 3 activation and dephosphorylation of PKB and GSK3 induced by K+ deprivation in cerebellar granule cells.
Journal of neurochemistry 2001;78(1):199-206.
2001: Sapkota G P; Kieloch A; Lizcano J M; Lain S; Arthur J S; Williams M R; Morrice N; Deak M; Alessi D R
Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth.
The Journal of biological chemistry 2001;276(22):19469-82.
2001: Alessi D R
Discovery of PDK1, one of the missing links in insulin signal transduction. Colworth Medal Lecture.
Biochemical Society transactions 2001;29(Pt 2):1-14.
2000: Balendran A; Hare G R; Kieloch A; Williams M R; Alessi D R
Further evidence that 3-phosphoinositide-dependent protein kinase-1 (PDK1) is required for the stability and phosphorylation of protein kinase C (PKC) isoforms.
FEBS letters 2000;484(3):217-23.
2000: Grillo S; Grémeaux T; Casamayor A; Alessi D R; Le Marchand-Brustel Y; Tanti J F
Peroxovanadate induces tyrosine phosphorylation of phosphoinositide-dependent protein kinase-1 potential involvement of src kinase.
European journal of biochemistry / FEBS 2000;267(22):6642-9.
2000: Dowler S; Currie R A; Campbell D G; Deak M; Kular G; Downes C P; Alessi D R
Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities.
The Biochemical journal 2000;351(Pt 1):19-31.
2000: Dowler S; Montalvo L; Cantrell D; Morrice N; Alessi D R
Phosphoinositide 3-kinase-dependent phosphorylation of the dual adaptor for phosphotyrosine and 3-phosphoinositides by the Src family of tyrosine kinase.
The Biochemical journal 2000;349(Pt 2):605-10.
2000: Balendran A; Biondi R M; Cheung P C; Casamayor A; Deak M; Alessi D R
A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1.
The Journal of biological chemistry 2000;275(27):20806-13.
2000: Williams M R; Arthur J S; Balendran A; van der Kaay J; Poli V; Cohen P; Alessi D R
The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells.
Current biology : CB 2000;10(8):439-48.
2000: Biondi R M; Cheung P C; Casamayor A; Deak M; Currie R A; Alessi D R
Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA.
The EMBO journal 2000;19(5):979-88.
2000: Cuenda A; Alessi D R
Use of kinase inhibitors to dissect signaling pathways.
Methods in molecular biology (Clifton, N.J.) 2000;99():161-75.
1999: Balendran A; Currie R; Armstrong C G; Avruch J; Alessi D R
Evidence that 3-phosphoinositide-dependent protein kinase-1 mediates phosphorylation of p70 S6 kinase in vivo at Thr-412 as well as Thr-252.
The Journal of biological chemistry 1999;274(52):37400-6.
1999: Casamayor A; Morrice N A; Alessi D R
Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo.
The Biochemical journal 1999;342 ( Pt 2)():287-92.
1999: Dowler S; Currie R A; Downes C P; Alessi D R
DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides.
The Biochemical journal 1999;342 ( Pt 1)():7-12.
1999: Deak M; Casamayor A; Currie R A; Downes C P; Alessi D R
Characterisation of a plant 3-phosphoinositide-dependent protein kinase-1 homologue which contains a pleckstrin homology domain.
FEBS letters 1999;451(3):220-6.
1999: Balendran A; Casamayor A; Deak M; Paterson A; Gaffney P; Currie R; Downes C P; Alessi D R
PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.
Current biology : CB 1999;9(8):393-404.
1999: Casamayor A; Torrance P D; Kobayashi T; Thorner J; Alessi D R
Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast.
Current biology : CB 1999;9(4):186-97.
1999: Currie R A; Walker K S; Gray A; Deak M; Casamayor A; Downes C P; Cohen P; Alessi D R; Lucocq J
Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1.
The Biochemical journal 1999;337 ( Pt 3)():575-83.
1998: Alessi D R; Downes C P
The role of PI 3-kinase in insulin action.
Biochimica et biophysica acta 1998;1436(1-2):151-64.
1998: Shaw M; Cohen P; Alessi D R
The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2.
The Biochemical journal 1998;336 ( Pt 1)():241-6.
1998: Deak M; Clifton A D; Lucocq L M; Alessi D R
Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB.
The EMBO journal 1998;17(15):4426-41.
1998: Hajduch E; Alessi D R; Hemmings B A; Hundal H S
Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells.
Diabetes 1998;47(7):1006-13.
1998: Walker K S; Deak M; Paterson A; Hudson K; Cohen P; Alessi D R
Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha.
The Biochemical journal 1998;331 ( Pt 1)():299-308.
1998: Alessi D R; Cohen P
Mechanism of activation and function of protein kinase B.
Current opinion in genetics & development 1998;8(1):55-62.
1998: Alessi D R; Kozlowski M T; Weng Q P; Morrice N; Avruch J
3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro.
Current biology : CB 1998;8(2):69-81.
1997: Shaw M; Cohen P; Alessi D R
Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216.
FEBS letters 1997;416(3):307-11.
1997: Alessi D R; Deak M; Casamayor A; Caudwell F B; Morrice N; Norman D G; Gaffney P; Reese C B; MacDougall C N; Harbison D; Ashworth A; Bownes M
3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase.
Current biology : CB 1997;7(10):776-89.
1997: Cohen P; Alessi D R; Cross D A
PDK1, one of the missing links in insulin signal transduction?
FEBS letters 1997;410(1):3-10.
1997: Alessi D R; James S R; Downes C P; Holmes A B; Gaffney P R; Reese C B; Cohen P
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha.
Current biology : CB 1997;7(4):261-9.
1997: Alessi D R
The protein kinase C inhibitors Ro 318220 and GF 109203X are equally potent inhibitors of MAPKAP kinase-1beta (Rsk-2) and p70 S6 kinase.
FEBS letters 1997;402(2-3):121-3.
1996: Alessi D R; Caudwell F B; Andjelkovic M; Hemmings B A; Cohen P
Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase.
FEBS letters 1996;399(3):333-8.
1996: Alessi D R; Andjelkovic M; Caudwell B; Cron P; Morrice N; Cohen P; Hemmings B A
Mechanism of activation of protein kinase B by insulin and IGF-1.
The EMBO journal 1996;15(23):6541-51.
1996: Groom L A; Sneddon A A; Alessi D R; Dowd S; Keyse S M
Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase.
The EMBO journal 1996;15(14):3621-32.
1996: James S R; Downes C P; Gigg R; Grove S J; Holmes A B; Alessi D R
Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation.
The Biochemical journal 1996;315 ( Pt 3)():709-13.
1995: Cross D A; Alessi D R; Cohen P; Andjelkovich M; Hemmings B A
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B.
Nature 1995;378(6559):785-9.
1995: Alessi D R; Cuenda A; Cohen P; Dudley D T; Saltiel A R
PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo.
The Journal of biological chemistry 1995;270(46):27489-94.
1995: Alessi D R; Gomez N; Moorhead G; Lewis T; Keyse S M; Cohen P
Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines.
Current biology : CB 1995;5(3):283-95.
1995: Alessi D R; Cohen P; Ashworth A; Cowley S; Leevers S J; Marshall C J
Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf.
Methods in enzymology 1995;255():279-90.
1994: Chen Y H; Chen M X; Alessi D R; Campbell D G; Shanahan C; Cohen P; Cohen P T
Molecular cloning of cDNA encoding the 110 kDa and 21 kDa regulatory subunits of smooth muscle protein phosphatase 1M.
FEBS letters 1994;356(1):51-5.
1994: Cross D A; Alessi D R; Vandenheede J R; McDowell H E; Hundal H S; Cohen P
The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf.
The Biochemical journal 1994;303 ( Pt 1)():21-6.
1994: Alessi D R; Saito Y; Campbell D G; Cohen P; Sithanandam G; Rapp U; Ashworth A; Marshall C J; Cowley S
Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.
The EMBO journal 1994;13(7):1610-9.
1993: Alessi D R; Smythe C; Keyse S M
The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts.
Oncogene 1993;8(7):2015-20.
1993: Alessi D R; Street A J; Cohen P; Cohen P T
Inhibitor-2 functions like a chaperone to fold three expressed isoforms of mammalian protein phosphatase-1 into a conformation with the specificity and regulatory properties of the native enzyme.
European journal of biochemistry / FEBS 1993;213(3):1055-66.
1992: Alessi D; MacDougall L K; Sola M M; Ikebe M; Cohen P
The control of protein phosphatase-1 by targetting subunits. The major myosin phosphatase in avian smooth muscle is a novel form of protein phosphatase-1.
European journal of biochemistry / FEBS 1992;210(3):1023-35.

Sign-in to see more