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Francis Chisari

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Martina Friesland; Francis V Chisari; Josan Chung; Lidia Mingorance; Pablo Gastaminza
Sigma-1 receptor regulates early steps of viral RNA replication at the onset of hepatitis C virus infection.
Marlène Dreux; Urtzi Garaigorta; Christina Whitten-Bauer; Stefan Wieland; Bryan Boyd; Josan Chung; Elodie Décembre; Francis V Chisari
Short-range exosomal transfer of viral RNA from infected cells to plasmacytoid dendritic cells triggers innate immunity.
Urtzi Garaigorta; Markus H Heim; Stefan Wieland; Bryan Boyd; Francis V Chisari
Hepatitis C virus (HCV) induces formation of stress granules whose proteins regulate HCV RNA replication and virus assembly and egress.

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All Publications

2013: Martina Friesland; Francis V Chisari; Josan Chung; Lidia Mingorance; Pablo Gastaminza
Sigma-1 receptor regulates early steps of viral RNA replication at the onset of hepatitis C virus infection.
Journal of virology 2013;87(11):6377-90.
2012: Marlène Dreux; Urtzi Garaigorta; Christina Whitten-Bauer; Stefan Wieland; Bryan Boyd; Josan Chung; Elodie Décembre; Francis V Chisari
Short-range exosomal transfer of viral RNA from infected cells to plasmacytoid dendritic cells triggers innate immunity.
Cell host & microbe 2012;12(4):558-70.
2012: Urtzi Garaigorta; Markus H Heim; Stefan Wieland; Bryan Boyd; Francis V Chisari
Hepatitis C virus (HCV) induces formation of stress granules whose proteins regulate HCV RNA replication and virus assembly and egress.
Journal of virology 2012;86(20):11043-56.
2012: Giovanni Sitia; Roberto Aiolfi; Francis V Chisari; Pietro Di Lucia; Antonio Esposito; Amleto Fiocchi; Matteo Iannacone; Marta Mainetti; Francesca Mingozzi; Zaverio M Ruggeri; Luca G Guidotti
Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(32):E2165-72.
2011: Ana Montero; Mansun Law; Guofeng Cheng; Francis V Chisari; Pablo Gastaminza; M Reza Ghadiri
Self-assembling peptide nanotubes with antiviral activity against hepatitis C virus.
Chemistry & biology 2011;18(11):1453-62.
2011: Francis V Chisari; Adolfo García-Sastre
Pioneers of pathogenesis: past and present.
Current opinion in virology 2011;1(3):157-9.
2011: Marlène Dreux; Francis V Chisari
Impact of the autophagy machinery on hepatitis C virus infection.
Viruses 2011;3(8):1342-57.
2011: Giovanni Sitia; Nico van Rooijen; Ulrich H von Andrian; Matteo Iannacone; Masanori Isogawa; Cristina Scozzesi; Roberto Aiolfi; Marco E Bianchi; Francis V Chisari; Luca G Guidotti
Kupffer cells hasten resolution of liver immunopathology in mouse models of viral hepatitis.
PLoS pathogens 2011;7(6):e1002061.
2011: Pablo Gastaminza; Suresh M Pitram; Marlene Dreux; Larissa Krasnova; Christina Whitten-Bauer; Jiajia Dong; Josan Chung; Valery V Fokin; K Barry Sharpless; Francis V Chisari
Antiviral stilbene 1,2-diamines prevent initiation of hepatitis C virus RNA replication at the outset of infection.
Journal of virology 2011;85(11):5513-23.
2010: Pablo Gastaminza; Kelly A Dryden; Bryan Boyd; Malcolm R Wood; Mansun Law; Mark Yeager; Francis V Chisari
Ultrastructural and biophysical characterization of hepatitis C virus particles produced in cell culture.
Journal of virology 2010;84(21):10999-1009.
2010: Francis V Chisari; Masanori Isogawa; Stefan F Wieland
Pathogenesis of hepatitis B virus infection.
Pathologie-biologie 2010;58(4):258-66.
2010: Marlène Dreux; Francis V Chisari
Viruses and the autophagy machinery.
Cell cycle (Georgetown, Tex.) 2010;9(7):1295-1307.
2010: Karl-Dimiter Bissig; Stefan F Wieland; Phu Tran; Masanori Isogawa; Tam T Le; Francis V Chisari; Inder M Verma
Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment.
The Journal of clinical investigation 2010;120(3):924-30.
2010: Prasanthi Bandi; Mayra L Garcia; Carmen J Booth; Francis V Chisari; Michael D Robek
Bortezomib inhibits hepatitis B virus replication in transgenic mice.
Antimicrobial agents and chemotherapy 2010;54(2):749-56.
2010: Priscilla L Yang; Alana Althage; Josan Chung; Holly Maier; Stefan F Wieland; Masanori Isogawa; Francis V Chisari
Immune effectors required for hepatitis B virus clearance.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(2):798-802.
2010: Pablo Gastaminza; Christina Whitten-Bauer; Francis V Chisari
Unbiased probing of the entire hepatitis C virus life cycle identifies clinical compounds that target multiple aspects of the infection.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(1):291-6.
2009: Urtzi Garaigorta; Francis V Chisari
Hepatitis C virus blocks interferon effector function by inducing protein kinase R phosphorylation.
Cell host & microbe 2009;6(6):513-22.
2009: Marlène Dreux; Francis V Chisari
Autophagy proteins promote hepatitis C virus replication.
Autophagy 2009;5(8):1224-5.
2009: Shinichi Asabe; Stefan F Wieland; Pratip K Chattopadhyay; Mario Roederer; Ronald E Engle; Robert Purcell; Francis V Chisari
The size of the viral inoculum contributes to the outcome of hepatitis B virus infection.
Journal of virology 2009;83(19):9652-62.
2009: Marlène Dreux; Pablo Gastaminza; Stefan F Wieland; Francis V Chisari
The autophagy machinery is required to initiate hepatitis C virus replication.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(33):14046-51.
2008: Jens Bukh; Robert Thimme; Jean-Christophe Meunier; Kristina Faulk; Hans Christian Spangenberg; Kyong-Mi Chang; William Satterfield; Francis V Chisari; Robert Purcell
Previously infected chimpanzees are not consistently protected against reinfection or persistent infection after reexposure to the identical hepatitis C virus strain.
Journal of virology 2008;82(16):8183-95.
2008: Michael D Bobardt; Guofeng Cheng; Lot de Witte; Suganya Selvarajah; Udayan Chatterji; Brigitte E Sanders-Beer; Teunis B H Geijtenbeek; Francis V Chisari; Philippe A Gallay
Hepatitis C virus NS5A anchor peptide disrupts human immunodeficiency virus.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(14):5525-30.
2008: Pablo Gastaminza; Guofeng Cheng; Stefan F Wieland; Jin Zhong; Wei Liao; Francis V Chisari
Cellular determinants of hepatitis C virus assembly, maturation, degradation, and secretion.
Journal of virology 2008;82(5):2120-9.
2008: Guofeng Cheng; Ana Montero; Pablo Gastaminza; Christina Whitten-Bauer; Stefan F Wieland; Masanori Isogawa; Brenda L Fredericksen; Suganya Selvarajah; Philippe A Gallay; M Reza Ghadiri; Francis V Chisari
A virocidal amphipathic {alpha}-helical peptide that inhibits hepatitis C virus infection in vitro.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(8):3088-93.
2008: Matteo Iannacone; Giovanni Sitia; Masanori Isogawa; Jason K Whitmire; Patrizia Marchese; Francis V Chisari; Zaverio M Ruggeri; Luca G Guidotti
Platelets prevent IFN-alpha/beta-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(2):629-34.
2008: Mansun Law; Toshiaki Maruyama; Jamie Lewis; Erick Giang; Alexander W Tarr; Zania Stamataki; Pablo Gastaminza; Francis V Chisari; Ian M Jones; Robert I Fox; Jonathan K Ball; Jane A McKeating; Norman M Kneteman; Dennis R Burton
Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge.
Nature medicine 2008;14(1):25-7.
2007: Irene M Pedersen; Guofeng Cheng; Stefan Wieland; Stefano Volinia; Carlo M Croce; Francis V Chisari; Michael David
Interferon modulation of cellular microRNAs as an antiviral mechanism.
Nature 2007;449(7164):919-22.
2007: John Sidney; Bjoern Peters; Carrie Moore; Timothy J Pencille; Sandy Ngo; Kelly-Anne Masterman; Shinichi Asabe; Clemencia Pinilla; Francis V Chisari; Alesandro Sette
Characterization of the peptide-binding specificity of the chimpanzee class I alleles A 0301 and A 0401 using a combinatorial peptide library.
Immunogenetics 2007;59(9):745-51.
2007: Akito Sakai; Shingo Takikawa; Robert Thimme; Jean-Christophe Meunier; Hans Christian Spangenberg; Sugantha Govindarajan; Patrizia Farci; Suzanne U Emerson; Francis V Chisari; Robert Purcell; Jens Bukh
In vivo study of the HC-TN strain of hepatitis C virus recovered from a patient with fulminant hepatitis: RNA transcripts of a molecular clone (pHC-TN) are infectious in chimpanzees but not in Huh7.5 cells.
Journal of virology 2007;81(13):7208-19.
2007: Guofeng Cheng; Jin Zhong; Josan Chung; Francis V Chisari
Double-stranded DNA and double-stranded RNA induce a common antiviral signaling pathway in human cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(21):9035-40.
2007: Holly Maier; Masanori Isogawa; Gordon J Freeman; Francis V Chisari
PD-1:PD-L1 interactions contribute to the functional suppression of virus-specific CD8+ T lymphocytes in the liver.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(5):2714-20.
2007: Michael D Robek; Mayra L Garcia; Bryan S Boyd; Francis V Chisari
Role of immunoproteasome catalytic subunits in the immune response to hepatitis B virus.
Journal of virology 2007;81(2):483-91.
2007: Sharookh B Kapadia; Heidi Barth; Thomas Baumert; Jane A McKeating; Francis V Chisari
Initiation of hepatitis C virus infection is dependent on cholesterol and cooperativity between CD81 and scavenger receptor B type I.
Journal of virology 2007;81(1):374-83.
2006: Pablo Gastaminza; Sharookh B Kapadia; Francis V Chisari
Differential biophysical properties of infectious intracellular and secreted hepatitis C virus particles.
Journal of virology 2006;80(22):11074-81.
2006: Jin Zhong; Pablo Gastaminza; Josan Chung; Zania Stamataki; Masanori Isogawa; Guofeng Cheng; Jane A McKeating; Francis V Chisari
Persistent hepatitis C virus infection in vitro: coevolution of virus and host.
Journal of virology 2006;80(22):11082-93.
2006: Bruno Sainz; Francis V Chisari
Production of infectious hepatitis C virus by well-differentiated, growth-arrested human hepatoma-derived cells.
Journal of virology 2006;80(20):10253-7.
2006: John Sidney; Shinichi Asabe; Bjoern Peters; Kelly-Anne Purton; Josan Chung; Timothy J Pencille; Robert Purcell; Christopher M Walker; Francis V Chisari; Alessandro Sette
Detailed characterization of the peptide binding specificity of five common Patr class I MHC molecules.
Immunogenetics 2006;58(7):559-70.
2006: Kelly Dryden; Stefan F Wieland; Christina Whitten-Bauer; John L Gerin; Francis V Chisari; Mark Yeager
Native hepatitis B virions and capsids visualized by electron cryomicroscopy.
Molecular cell 2006;22(6):843-50.
2006: Guofeng Cheng; Jin Zhong; Francis V Chisari
Inhibition of dsRNA-induced signaling in hepatitis C virus-infected cells by NS3 protease-dependent and -independent mechanisms.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(22):8499-504.
2006: Kiminori Kimura; Hisataka Moriwaki; Masahito Nagaki; Masanao Saio; Yasunari Nakamoto; Makoto Naito; Kazuo Kuwata; Francis V Chisari
Pathogenic role of B cells in anti-CD40-induced necroinflammatory liver disease.
The American journal of pathology 2006;168(3):786-95.
2006: Luca G Guidotti; Francis V Chisari
Immunobiology and pathogenesis of viral hepatitis.
Annual review of pathology 2006;1():23-61.
2006: Susan L Uprichard; Josan Chung; Francis V Chisari; Takaji Wakita
Replication of a hepatitis C virus replicon clone in mouse cells.
Virology journal 2006;3():89.
2005: John M Murray; Stefan F Wieland; Robert Purcell; Francis V Chisari
Dynamics of hepatitis B virus clearance in chimpanzees.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(49):17780-5.
2005: Matteo Iannacone; Giovanni Sitia; Masanori Isogawa; Patrizia Marchese; Maria G Castro; Pedro R Lowenstein; Francis V Chisari; Zaverio M Ruggeri; Luca G Guidotti
Platelets mediate cytotoxic T lymphocyte-induced liver damage.
Nature medicine 2005;11(11):1167-9.
2005: Robert J C Gilbert; Lucy P Beales; Donatienne Blond; Martha N Simon; Beth Y Lin; Francis V Chisari; David I Stuart; David J Rowlands
Hepatitis B small surface antigen particles are octahedral.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(41):14783-8.
2005: Francis V Chisari
Unscrambling hepatitis C virus-host interactions.
Nature 2005;436(7053):930-2.
2005: Stefan F Wieland; Francis V Chisari
Stealth and cunning: hepatitis B and hepatitis C viruses.
Journal of virology 2005;79(15):9369-80.
2005: Stefan F Wieland; Angelina Eustaquio; Christina Whitten-Bauer; Bryan S Boyd; Francis V Chisari
Interferon prevents formation of replication-competent hepatitis B virus RNA-containing nucleocapsids.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(28):9913-7.
2005: Masanori Isogawa; Yoshihiro Furuichi; Francis V Chisari
Oscillating CD8(+) T cell effector functions after antigen recognition in the liver.
Immunity 2005;23(1):53-63.
2005: Jin Zhong; Pablo Gastaminza; Guofeng Cheng; Sharookh B Kapadia; Takanobu Kato; Dennis R Burton; Stefan F Wieland; Susan L Uprichard; Takaji Wakita; Francis V Chisari
Robust hepatitis C virus infection in vitro.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(26):9294-9.
2005: Masanori Isogawa; Michael D Robek; Yoshihiro Furuichi; Francis V Chisari
Toll-like receptor signaling inhibits hepatitis B virus replication in vivo.
Journal of virology 2005;79(11):7269-72.
2005: Huynh-Hoa Bui; John Sidney; Bjoern Peters; Muthuraman Sathiamurthy; Asabe Sinichi; Kelly-Anne Purton; Bianca R Mothé; Francis V Chisari; David Ian Watkins; Alessandro Sette
Automated generation and evaluation of specific MHC binding predictive tools: ARB matrix applications.
Immunogenetics 2005;57(5):304-14.
2005: Masanori Isogawa; Kazuhiro Kakimi; Hiroyuki Kamamoto; Ulrike Protzer; Francis V Chisari
Differential dynamics of the peripheral and intrahepatic cytotoxic T lymphocyte response to hepatitis B surface antigen.
Virology 2005;333(2):293-300.
2005: Michael D Robek; Bryan S Boyd; Francis V Chisari
Lambda interferon inhibits hepatitis B and C virus replication.
Journal of virology 2005;79(6):3851-4.
2005: Margaret Chen; Matti Sällberg; Janice Hughes; Joyce Jones; Luca G Guidotti; Francis V Chisari; Jean-Noel Billaud; David R Milich
Immune tolerance split between hepatitis B virus precore and core proteins.
Journal of virology 2005;79(5):3016-27.
2005: Sharookh B Kapadia; Francis V Chisari
Hepatitis C virus RNA replication is regulated by host geranylgeranylation and fatty acids.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(7):2561-6.
2005: Susan L Uprichard; Bryan S Boyd; Alana Althage; Francis V Chisari
Clearance of hepatitis B virus from the liver of transgenic mice by short hairpin RNAs.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(3):773-8.
2004: Margaret T Chen; Jean-Noel Billaud; Matti Sällberg; Luca G Guidotti; Francis V Chisari; Joyce Jones; Janice Hughes; David R Milich
A function of the hepatitis B virus precore protein is to regulate the immune response to the core antigen.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(41):14913-8.
2004: Stefan F Wieland; Robert Thimme; Robert Purcell; Francis V Chisari
Genomic analysis of the host response to hepatitis B virus infection.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(17):6669-74.
2004: Giovanni Sitia; Masanori Isogawa; Matteo Iannacone; Iain L Campbell; Francis V Chisari; Luca G Guidotti
MMPs are required for recruitment of antigen-nonspecific mononuclear cells into the liver by CTLs.
The Journal of clinical investigation 2004;113(8):1158-67.
2004: Stefan F Wieland; Hans Christian Spangenberg; Robert Thimme; Robert Purcell; Francis V Chisari
Expansion and contraction of the hepatitis B virus transcriptional template in infected chimpanzees.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(7):2129-34.
2004: Michael D Robek; Bryan S Boyd; Stefan F Wieland; Francis V Chisari
Signal transduction pathways that inhibit hepatitis B virus replication.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(6):1743-7.
2003: Sharookh B Kapadia; Amy Brideau-Andersen; Francis V Chisari
Interference of hepatitis C virus RNA replication by short interfering RNAs.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):2014-8.
2003: Susan L Uprichard; Stefan F Wieland; Alana Althage; Francis V Chisari
Transcriptional and posttranscriptional control of hepatitis B virus gene expression.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):1310-5.
2003: Stefan F Wieland; Raquel G Vega; Rolf Müller; Claire F Evans; Brian S Hilbush; Luca G Guidotti; J Gregor Sutcliffe; Peter G Schultz; Francis V Chisari
Searching for interferon-induced genes that inhibit hepatitis B virus replication in transgenic mouse hepatocytes.
Journal of virology 2003;77(2):1227-36.
2003: Robert Thimme; Stefan F Wieland; Carola Steiger; John Ghrayeb; Keith A Reimann; Robert Purcell; Francis V Chisari
CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection.
Journal of virology 2003;77(1):68-76.
2002: Robert Thimme; Jens Bukh; Hans Christian Spangenberg; Stefan F Wieland; Janell Pemberton; Carola Steiger; Sugantha Govindarajan; Robert Purcell; Francis V Chisari
Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(24):15661-8.
2002: Andrew Su; John Paul Pezacki; Lisa Wodicka; Amy D Brideau; Lubica Supekova; Robert Thimme; Stefan F Wieland; Jens Bukh; Robert Purcell; Peter G Schultz; Francis V Chisari
Genomic analysis of the host response to hepatitis C virus infection.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(24):15669-74.
2002: Kiminori Kimura; Kazuhiro Kakimi; Stefan F Wieland; Luca G Guidotti; Francis V Chisari
Activated intrahepatic antigen-presenting cells inhibit hepatitis B virus replication in the liver of transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(9):5188-95.
2002: Kiminori Kimura; Kazuhiro Kakimi; Stefan F Wieland; Luca G Guidotti; Francis V Chisari
Interleukin-18 inhibits hepatitis B virus replication in the livers of transgenic mice.
Journal of virology 2002;76(21):10702-7.
2002: Priscilla L Yang; Alana Althage; Josan Chung; Francis V Chisari
Hydrodynamic injection of viral DNA: a mouse model of acute hepatitis B virus infection.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(21):13825-30.
2002: Giovanni Sitia; Masanori Isogawa; Kazuhiro Kakimi; Stefan F Wieland; Francis V Chisari; Luca G Guidotti
Depletion of neutrophils blocks the recruitment of antigen-nonspecific cells into the liver without affecting the antiviral activity of hepatitis B virus-specific cytotoxic T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(21):13717-22.
2002: Kazuhiro Kakimi; Masanori Isogawa; Josan Chung; Alessandro Sette; Francis V Chisari
Immunogenicity and tolerogenicity of hepatitis B virus structural and nonstructural proteins: implications for immunotherapy of persistent viral infections.
Journal of virology 2002;76(17):8609-20.
2002: Andrew Su; Luca G Guidotti; John Paul Pezacki; Francis V Chisari; Peter G Schultz
Gene expression during the priming phase of liver regeneration after partial hepatectomy in mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):11181-6.
2002: Valerie Pasquetto; Stefan F Wieland; Susan L Uprichard; Marco Tripodi; Francis V Chisari
Cytokine-sensitive replication of hepatitis B virus in immortalized mouse hepatocyte cultures.
Journal of virology 2002;76(11):5646-53.
2002: Michael D Robek; Stefan F Wieland; Francis V Chisari
Inhibition of hepatitis B virus replication by interferon requires proteasome activity.
Journal of virology 2002;76(7):3570-4.
2002: Luca G Guidotti; Amber Morris; Heike Mendez; Rick Koch; Robert H Silverman; Bryan R G Williams; Francis V Chisari
Interferon-regulated pathways that control hepatitis B virus replication in transgenic mice.
Journal of virology 2002;76(6):2617-21.
2002: Donald E Mosier; Francis V Chisari
GB virus C and mortality from HIV infection.
The New England journal of medicine 2002;346(5):377-9.
2001: Kazuhiro Kakimi; Thomas E Lane; Stefan F Wieland; Valérie C Asensio; Iain L Campbell; Francis V Chisari; Luca G Guidotti
Blocking chemokine responsive to gamma-2/interferon (IFN)-gamma inducible protein and monokine induced by IFN-gamma activity in vivo reduces the pathogenetic but not the antiviral potential of hepatitis B virus-specific cytotoxic T lymphocytes.
The Journal of experimental medicine 2001;194(12):1755-66.
2001: Kazuhiro Kakimi; Thomas E Lane; Francis V Chisari; Luca G Guidotti
Cutting edge: Inhibition of hepatitis B virus replication by activated NK T cells does not require inflammatory cell recruitment to the liver.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(12):6701-5.
2001: Robert Thimme; David W Oldach; KM Chang; Carola Steiger; Stuart C Ray; Francis V Chisari
Determinants of viral clearance and persistence during acute hepatitis C virus infection.
The Journal of experimental medicine 2001;194(10):1395-406.
2001: Tilman Heise; Luca G Guidotti; Francis V Chisari
Characterization of nuclear RNases that cleave hepatitis B virus RNA near the La protein binding site.
Journal of virology 2001;75(15):6874-83.
2001: Robert Thimme; KM Chang; Janell Pemberton; Alessandro Sette; Francis V Chisari
Degenerate immunogenicity of an HLA-A2-restricted hepatitis B virus nucleocapsid cytotoxic T-lymphocyte epitope that is also presented by HLA-B51.
Journal of virology 2001;75(8):3984-7.
2001: Alessandro Sette; Carla Oseroff; John Sidney; J Alexander; Robert W Chesnut; Kazuhiro Kakimi; Luca G Guidotti; Francis V Chisari
Overcoming T cell tolerance to the hepatitis B virus surface antigen in hepatitis B virus-transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(2):1389-97.
2001: Luca G Guidotti; Francis V Chisari
Noncytolytic control of viral infections by the innate and adaptive immune response.
Annual review of immunology 2001;19():65-91.
2001: KM Chang; Robert Thimme; J J Melpolder; David W Oldach; Janell Pemberton; J Moorhead-Loudis; J G McHutchison; Harvey Alter; Francis V Chisari
Differential CD4(+) and CD8(+) T-cell responsiveness in hepatitis C virus infection.
Hepatology (Baltimore, Md.) 2001;33(1):267-76.
2000: Kazuhiro Kakimi; Luca G Guidotti; Y Koezuka; Francis V Chisari
Natural killer T cell activation inhibits hepatitis B virus replication in vivo.
The Journal of experimental medicine 2000;192(7):921-30.
2000: Valerie Pasquetto; Stefan F Wieland; Francis V Chisari
Intracellular hepatitis B virus nucleocapsids survive cytotoxic T-lymphocyte-induced apoptosis.
Journal of virology 2000;74(20):9792-6.
2000: Valerie Pasquetto; Luca G Guidotti; Kazuhiro Kakimi; Moriya Tsuji; Francis V Chisari
Host-virus interactions during malaria infection in hepatitis B virus transgenic mice.
The Journal of experimental medicine 2000;192(4):529-36.
2000: L G Guidotti; Francis V Chisari
Cytokine-mediated control of viral infections.
Virology 2000;273(2):221-7.
2000: H McClary; Rick Koch; Francis V Chisari; Luca G Guidotti
Inhibition of hepatitis B virus replication during schistosoma mansoni infection in transgenic mice.
The Journal of experimental medicine 2000;192(2):289-94.
2000: Stefan F Wieland; Luca G Guidotti; Francis V Chisari
Intrahepatic induction of alpha/beta interferon eliminates viral RNA-containing capsids in hepatitis B virus transgenic mice.
Journal of virology 2000;74(9):4165-73.
2000: Luca G Guidotti; H McClary; J M Loudis; Francis V Chisari
Nitric oxide inhibits hepatitis B virus replication in the livers of transgenic mice.
The Journal of experimental medicine 2000;191(7):1247-52.
2000: Francis V Chisari
Rous-Whipple Award Lecture. Viruses, immunity, and cancer: lessons from hepatitis B.
The American journal of pathology 2000;156(4):1117-32.
2000: H McClary; Rick Koch; Francis V Chisari; Luca G Guidotti
Relative sensitivity of hepatitis B virus and other hepatotropic viruses to the antiviral effects of cytokines.
Journal of virology 2000;74(5):2255-64.
1999: Tilman Heise; Luca G Guidotti; Francis V Chisari
La autoantigen specifically recognizes a predicted stem-loop in hepatitis B virus RNA.
Journal of virology 1999;73(7):5767-76.
1999: Ursula Schultz; J Summers; Peter Staeheli; Francis V Chisari
Elimination of duck hepatitis B virus RNA-containing capsids in duck interferon-alpha-treated hepatocytes.
Journal of virology 1999;73(7):5459-65.
1999: Luca G Guidotti; Persephone Borrow; A Brown; H McClary; Rick Koch; Francis V Chisari
Noncytopathic clearance of lymphocytic choriomeningitis virus from the hepatocyte.
The Journal of experimental medicine 1999;189(10):1555-64.
1999: Luca G Guidotti; Rosemary Rochford; Josan Chung; M Shapiro; Robert Purcell; Francis V Chisari
Viral clearance without destruction of infected cells during acute HBV infection.
Science (New York, N.Y.) 1999;284(5415):825-9.
1999: Ursula Schultz; Francis V Chisari
Recombinant duck interferon gamma inhibits duck hepatitis B virus replication in primary hepatocytes.
Journal of virology 1999;73(4):3162-8.
1999: Brian D Livingston; Jeff Alexander; Claire Crimi; Carla Oseroff; E Celis; K Daly; Luca G Guidotti; Francis V Chisari; John Fikes; Robert W Chesnut; Alessandro Sette
Altered helper T lymphocyte function associated with chronic hepatitis B virus infection and its role in response to therapeutic vaccination in humans.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(5):3088-95.
1999: K M Chang; Norbert H Gruener; Scott Southwood; John Sidney; G R Pape; Francis V Chisari; Alessandro Sette
Identification of HLA-A3 and -B7-restricted CTL response to hepatitis C virus in patients with acute and chronic hepatitis C.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(2):1156-64.
1999: Tilman Heise; Luca G Guidotti; VJ Cavanaugh; Francis V Chisari
Hepatitis B virus RNA-binding proteins associated with cytokine-induced clearance of viral RNA from the liver of transgenic mice.
Journal of virology 1999;73(1):474-81.
1998: Jeff Alexander; Marie-France del Guercio; John Fikes; Robert W Chesnut; Francis V Chisari; K M Chang; Ettore Appella; Alessandro Sette
Recognition of a novel naturally processed, A2 restricted, HCV-NS4 epitope triggers IFN-gamma release in absence of detectable cytopathicity.
Human immunology 1998;59(12):776-82.
1998: Y Shimizu; Luca G Guidotti; P Fowler; Francis V Chisari
Dendritic cell immunization breaks cytotoxic T lymphocyte tolerance in hepatitis B virus transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(9):4520-9.
1998: Y Nakamoto; Luca G Guidotti; C V Kuhlen; P Fowler; Francis V Chisari
Immune pathogenesis of hepatocellular carcinoma.
The Journal of experimental medicine 1998;188(2):341-50.
1998: VJ Cavanaugh; Luca G Guidotti; Francis V Chisari
Inhibition of hepatitis B virus replication during adenovirus and cytomegalovirus infections in transgenic mice.
Journal of virology 1998;72(4):2630-7.
1998: J Alexander; John Fikes; S Hoffman; ED Franke; John B Sacci; Ettore Appella; Francis V Chisari; Luca G Guidotti; Robert W Chesnut; Brian D Livingston; A Sette
The optimization of helper T lymphocyte (HTL) function in vaccine development.
Immunologic research 1998;18(2):79-92.
1997: Jeff Alexander; Carla Oseroff; John Sidney; PA Wentworth; E Keogh; G Hermanson; Francis V Chisari; RT Kubo; Howard Grey; Alessandro Sette
Derivation of HLA-A11/Kb transgenic mice: functional CTL repertoire and recognition of human A11-restricted CTL epitopes.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(10):4753-61.
1997: KM Chang; B Rehermann; J G McHutchison; C Pasquinelli; Scott Southwood; Alessandro Sette; Francis V Chisari
Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus.
The Journal of clinical investigation 1997;100(9):2376-85.
1997: A Franco; Luca G Guidotti; Monte V Hobbs; Valerie Pasquetto; Francis V Chisari
Pathogenetic effector function of CD4-positive T helper 1 cells in hepatitis B virus transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(4):2001-8.
1997: R Bertoni; J Sidney; P Fowler; R W Chesnut; Francis V Chisari; Alessandro Sette
Human histocompatibility leukocyte antigen-binding supermotifs predict broadly cross-reactive cytotoxic T lymphocyte responses in patients with acute hepatitis.
The Journal of clinical investigation 1997;100(3):503-13.
1997: Brian D Livingston; Claire Crimi; Howard Grey; Glenn Ishioka; Francis V Chisari; John Fikes; H Grey; Robert W Chesnut; Alessandro Sette
The hepatitis B virus-specific CTL responses induced in humans by lipopeptide vaccination are comparable to those elicited by acute viral infection.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(3):1383-92.
1997: Y Nakamoto; Luca G Guidotti; Valerie Pasquetto; R D Schreiber; Francis V Chisari
Differential target cell sensitivity to CTL-activated death pathways in hepatitis B virus transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(12):5692-7.
1997: Luca G Guidotti; B Matzke; Francis V Chisari
Hepatitis B virus replication is cell cycle independent during liver regeneration in transgenic mice.
Journal of virology 1997;71(6):4804-8.
1997: Francis V Chisari
Cytotoxic T cells and viral hepatitis.
The Journal of clinical investigation 1997;99(7):1472-7.
1997: VJ Cavanaugh; Luca G Guidotti; Francis V Chisari
Interleukin-12 inhibits hepatitis B virus replication in transgenic mice.
Journal of virology 1997;71(4):3236-43.
1997: C Pasquinelli; J M Shoenberger; J Chung; KM Chang; Luca G Guidotti; Mark Selby; K Berger; R Lesniewski; Michael Houghton; Francis V Chisari
Hepatitis C virus core and E2 protein expression in transgenic mice.
Hepatology (Baltimore, Md.) 1997;25(3):719-27.
1997: KM Chang; B Rehermann; Francis V Chisari
Immunopathology of hepatitis C.
Springer seminars in immunopathology 1997;19(1):57-68.
1996: B Rehermann; C Ferrari; C Pasquinelli; Francis V Chisari
The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response.
Nature medicine 1996;2(10):1104-8.
1996: B Rehermann; KM Chang; J McHutchinson; R Kokka; Michael Houghton; C M Rice; Francis V Chisari
Differential cytotoxic T-lymphocyte responsiveness to the hepatitis B and C viruses in chronically infected patients.
Journal of virology 1996;70(10):7092-102.
1996: Luca G Guidotti; B Matzke; C Pasquinelli; J M Shoenberger; Charles E Rogler; Francis V Chisari
The hepatitis B virus (HBV) precore protein inhibits HBV replication in transgenic mice.
Journal of virology 1996;70(10):7056-61.
1996: B Rehermann; KM Chang; J G McHutchison; R Kokka; Michael Houghton; Francis V Chisari
Quantitative analysis of the peripheral blood cytotoxic T lymphocyte response in patients with chronic hepatitis C virus infection.
The Journal of clinical investigation 1996;98(6):1432-40.
1996: Amalia Penna; Marco Artini; Albertina Cavalli; Massimo Levrero; Antonio Bertoletti; Massimo Pilli; Francis V Chisari; B Rehermann; Gianfranco Del Prete; F Fiaccadori; Carlo Ferrari
Long-lasting memory T cell responses following self-limited acute hepatitis B.
The Journal of clinical investigation 1996;98(5):1185-94.
1996: Luca G Guidotti; Persephone Borrow; Monte V Hobbs; B Matzke; I Gresser; Michael B A Oldstone; Francis V Chisari
Viral cross talk: intracellular inactivation of the hepatitis B virus during an unrelated viral infection of the liver.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(10):4589-94.
1996: PA Wentworth; Alessandro Sette; E Celis; John Sidney; Scott Southwood; Claire Crimi; S Stitely; Elissa Keogh; N C Wong; Brian D Livingston; D Alazard; Antonella Vitiello; Howard Grey; Francis V Chisari; Robert W Chesnut; John Fikes
Identification of A2-restricted hepatitis C virus-specific cytotoxic T lymphocyte epitopes from conserved regions of the viral genome.
International immunology 1996;8(5):651-9.
1996: B Rehermann; D Lau; J H Hoofnagle; Francis V Chisari
Cytotoxic T lymphocyte responsiveness after resolution of chronic hepatitis B virus infection.
The Journal of clinical investigation 1996;97(7):1655-65.
1996: Francis V Chisari
Hepatitis B virus transgenic mice: models of viral immunobiology and pathogenesis.
Current topics in microbiology and immunology 1996;206():149-73.
1996: Luca G Guidotti; T Ishikawa; Monte V Hobbs; B Matzke; R Schreiber; Francis V Chisari
Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes.
Immunity 1996;4(1):25-36.
1995: L V Tsui; Luca G Guidotti; T Ishikawa; Francis V Chisari
Posttranscriptional clearance of hepatitis B virus RNA by cytotoxic T lymphocyte-activated hepatocytes.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(26):12398-402.
1995: Luca G Guidotti; B Matzke; H Schaller; Francis V Chisari
High-level hepatitis B virus replication in transgenic mice.
Journal of virology 1995;69(10):6158-69.
1995: Francis V Chisari
Hepatitis B virus transgenic mice: insights into the virus and the disease.
Hepatology (Baltimore, Md.) 1995;22(4 Pt 1):1316-25.
1995: B Rehermann; C Pasquinelli; S M Mosier; Francis V Chisari
Hepatitis B virus (HBV) sequence variation of cytotoxic T lymphocyte epitopes is not common in patients with chronic HBV infection.
The Journal of clinical investigation 1995;96(3):1527-34.
1995: PA Wentworth; E Celis; Claire Crimi; S Stitely; L Hale; V Tsai; H M Serra; Marie-France del Guercio; Brian D Livingston; D Alazard; John Fikes; RT Kubo; Howard Grey; Robert W Chesnut; Francis V Chisari; Alessandro Sette
In vitro induction of primary, antigen-specific CTL from human peripheral blood mononuclear cells stimulated with synthetic peptides.
Molecular immunology 1995;32(9):603-12.
1995: S Wirth; Luca G Guidotti; K Ando; Hans-Jürgen Schlicht; Francis V Chisari
Breaking tolerance leads to autoantibody production but not autoimmune liver disease in hepatitis B virus envelope transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(5):2504-15.
1995: B Rehermann; P Fowler; John Sidney; J Person; Allan Redeker; M Brown; Bernard Moss; Alessandro Sette; Francis V Chisari
The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis.
The Journal of experimental medicine 1995;181(3):1047-58.
1995: Andreas Cerny; P Fowler; M A Brothers; Michael Houghton; Hans-Jürgen Schlicht; Francis V Chisari
Induction in vitro of a primary human antiviral cytotoxic T cell response.
European journal of immunology 1995;25(2):627-30.
1995: Andreas Cerny; J G McHutchison; C Pasquinelli; M E Brown; M A Brothers; B Grabscheid; P Fowler; Michael Houghton; Francis V Chisari
Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif.
The Journal of clinical investigation 1995;95(2):521-30.
1995: Francis V Chisari; C Ferrari
Hepatitis B virus immunopathology.
Springer seminars in immunopathology 1995;17(2-3):261-81.
1995: Antonella Vitiello; Glenn Ishioka; Howard Grey; R Rose; P Farness; R LaFond; L Yuan; Francis V Chisari; J Furze; R Bartholomeuz
Development of a lipopeptide-based therapeutic vaccine to treat chronic HBV infection. I. Induction of a primary cytotoxic T lymphocyte response in humans.
The Journal of clinical investigation 1995;95(1):341-9.
1995: Francis V Chisari; C Ferrari
Hepatitis B virus immunopathogenesis.
Annual review of immunology 1995;13():29-60.
1994: Alessandro Sette; Antonella Vitiello; B Reherman; P Fowler; R Nayersina; W Martin Kast; Cornelis J M Melief; Carla Oseroff; L Yuan; J Ruppert; John Sidney; Marie-France del Guercio; Scott Southwood; RT Kubo; Robert W Chesnut; Howard Grey; Francis V Chisari
The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(12):5586-92.
1994: Luca G Guidotti; V Martinez; Y T Loh; Charles E Rogler; Francis V Chisari
Hepatitis B virus nucleocapsid particles do not cross the hepatocyte nuclear membrane in transgenic mice.
Journal of virology 1994;68(9):5469-75.
1994: Antonio Bertoletti; A Costanzo; Francis V Chisari; Massimo Levrero; Marco Artini; A Sette; Amalia Penna; T Giuberti; F Fiaccadori; Carlo Ferrari
Cytotoxic T lymphocyte response to a wild type hepatitis B virus epitope in patients chronically infected by variant viruses carrying substitutions within the epitope.
The Journal of experimental medicine 1994;180(3):933-43.
1994: T I Michalak; C Pasquinelli; S Guilhot; Francis V Chisari
Hepatitis B virus persistence after recovery from acute viral hepatitis.
The Journal of clinical investigation 1994;94(2):907.
1994: Antonio Bertoletti; A Sette; Francis V Chisari; Amalia Penna; Massimo Levrero; M De Carli; F Fiaccadori; Carlo Ferrari
Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells.
Nature 1994;369(6479):407-10.
1994: Luca G Guidotti; K Ando; Monte V Hobbs; T Ishikawa; L Runkel; R D Schreiber; Francis V Chisari
Cytotoxic T lymphocytes inhibit hepatitis B virus gene expression by a noncytolytic mechanism in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(9):3764-8.
1994: K Ando; Luca G Guidotti; S Wirth; T Ishikawa; Gabriele Missale; T Moriyama; R D Schreiber; Hans-Jürgen Schlicht; S N Huang; Francis V Chisari
Class I-restricted cytotoxic T lymphocytes are directly cytopathic for their target cells in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(7):3245-53.
1994: Luca G Guidotti; S Guilhot; Francis V Chisari
Interleukin-2 and alpha/beta interferon down-regulate hepatitis B virus gene expression in vivo by tumor necrosis factor-dependent and -independent pathways.
Journal of virology 1994;68(3):1265-70.
1994: S Guilhot; S N Huang; Y P Xia; Nicola La Monica; M M Lai; Francis V Chisari
Expression of the hepatitis delta virus large and small antigens in transgenic mice.
Journal of virology 1994;68(2):1052-8.
1994: T I Michalak; C Pasquinelli; S Guilhot; Francis V Chisari
Hepatitis B virus persistence after recovery from acute viral hepatitis.
The Journal of clinical investigation 1994;93(1):230-9.
1993: S Guilhot; Luca G Guidotti; Francis V Chisari
Interleukin-2 downregulates hepatitis B virus gene expression in transgenic mice by a posttranscriptional mechanism.
Journal of virology 1993;67(12):7444-9.
1993: K Ando; T Moriyama; Luca G Guidotti; S Wirth; R D Schreiber; Hans-Jürgen Schlicht; S N Huang; Francis V Chisari
Mechanisms of class I restricted immunopathology. A transgenic mouse model of fulminant hepatitis.
The Journal of experimental medicine 1993;178(5):1541-54.
1993: Gabriele Missale; J J Brems; H Takiff; P J Pockros; Francis V Chisari
Human leukocyte antigen class I-independent pathways may contribute to hepatitis B virus-induced liver disease after liver transplantation.
Hepatology (Baltimore, Md.) 1993;18(3):491-6.
1993: R Nayersina; P Fowler; S Guilhot; Gabriele Missale; Andreas Cerny; Hans-Jürgen Schlicht; Antonella Vitiello; R Chesnut; J L Person; Allan Redeker; Francis V Chisari
HLA A2 restricted cytotoxic T lymphocyte responses to multiple hepatitis B surface antigen epitopes during hepatitis B virus infection.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(10):4659-71.
1993: Antonio Bertoletti; Francis V Chisari; Amalia Penna; S Guilhot; L Galati; Gabriele Missale; P Fowler; Hans-Jürgen Schlicht; Antonella Vitiello; R C Chesnut
Definition of a minimal optimal cytotoxic T-cell epitope within the hepatitis B virus nucleocapsid protein.
Journal of virology 1993;67(4):2376-80.
1993: Gabriele Missale; Allan Redeker; J Person; P Fowler; S Guilhot; Hans-Jürgen Schlicht; C Ferrari; Francis V Chisari
HLA-A31- and HLA-Aw68-restricted cytotoxic T cell responses to a single hepatitis B virus nucleocapsid epitope during acute viral hepatitis.
The Journal of experimental medicine 1993;177(3):751-62.
1992: P N Gilles; D L Guerrette; R J Ulevitch; R D Schreiber; Francis V Chisari
HBsAg retention sensitizes the hepatocyte to injury by physiological concentrations of interferon-gamma.
Hepatology (Baltimore, Md.) 1992;16(3):655-63.
1992: P N Gilles; Georg H Fey; Francis V Chisari
Tumor necrosis factor alpha negatively regulates hepatitis B virus gene expression in transgenic mice.
Journal of virology 1992;66(6):3955-60.
1992: C Pasquinelli; K Bhavani; Francis V Chisari
Multiple oncogenes and tumor suppressor genes are structurally and functionally intact during hepatocarcinogenesis in hepatitis B virus transgenic mice.
Cancer research 1992;52(10):2823-9.
1992: S Guilhot; P Fowler; G Portillo; R F Margolskee; C Ferrari; Antonio Bertoletti; Francis V Chisari
Hepatitis B virus (HBV)-specific cytotoxic T-cell response in humans: production of target cells by stable expression of HBV-encoded proteins in immortalized human B-cell lines.
Journal of virology 1992;66(5):2670-8.
1992: Amalia Penna; P Fowler; Antonio Bertoletti; S Guilhot; Bernard Moss; R F Margolskee; Albertina Cavalli; A Valli; F Fiaccadori; Francis V Chisari
Hepatitis B virus (HBV)-specific cytotoxic T-cell (CTL) response in humans: characterization of HLA class II-restricted CTLs that recognize endogenously synthesized HBV envelope antigens.
Journal of virology 1992;66(2):1193-8.
1992: Amalia Penna; Antonio Bertoletti; Albertina Cavalli; A Valli; Gabriele Missale; Massimo Pilli; S Marchelli; T Giuberti; P Fowler; Francis V Chisari
Fine specificity of the human T cell response to hepatitis B virus core antigen.
Archives of virology. Supplementum 1992;4():23-8.
1991: Amalia Penna; Francis V Chisari; Antonio Bertoletti; Gabriele Missale; P Fowler; T Giuberti; F Fiaccadori; Carlo Ferrari
Cytotoxic T lymphocytes recognize an HLA-A2-restricted epitope within the hepatitis B virus nucleocapsid antigen.
The Journal of experimental medicine 1991;174(6):1565-70.
1991: Antonio Bertoletti; C Ferrari; F Fiaccadori; Amalia Penna; R Margolskee; Hans-Jürgen Schlicht; P Fowler; S Guilhot; Francis V Chisari
HLA class I-restricted human cytotoxic T cells recognize endogenously synthesized hepatitis B virus nucleocapsid antigen.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(23):10445-9.
1991: Carlo Ferrari; Antonio Bertoletti; Amalia Penna; Albertina Cavalli; A Valli; Gabriele Missale; Massimo Pilli; P Fowler; T Giuberti; Francis V Chisari
Identification of immunodominant T cell epitopes of the hepatitis B virus nucleocapsid antigen.
The Journal of clinical investigation 1991;88(1):214-22.
1989: Francis V Chisari; K Klopchin; T Moriyama; C Pasquinelli; H A Dunsford; S Sell; C A Pinkert; R L Brinster; R D Palmiter
Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice.
Cell 1989;59(6):1145-56.
1987: C Ferrari; Amalia Penna; T Giuberti; M J Tong; E Ribera; F Fiaccadori; Francis V Chisari
Intrahepatic, nucleocapsid antigen-specific T cells in chronic active hepatitis B.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(6):2050-8.
1986: C Ferrari; Amalia Penna; P Sansoni; T Giuberti; T M Neri; Francis V Chisari; F Fiaccadori
Selective sensitization of peripheral blood T lymphocytes to hepatitis B core antigen in patients with chronic active hepatitis type B.
Clinical and experimental immunology 1986;66(3):497-506.