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Christopher Chitambar

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
13
Wereley, Janine
7
Antholine, William
6
Kotamraju, Srigiridhar
5
Whelan, Harry
5
Joseph, Joy
5
Kalyanaraman, Balaraman
4
Kampalath, Bal
4
Kalivendi, Shasi
4
Chang, Chung-Che
3
Efferth, Thomas
3
Lawton, Colleen
3
O'Brien, William
3
Yang, Meiying
3
Sauerbrey, Axel
3
Tampo, Yoshiko

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Publications

TOP 3
Yang Meiying; Chitambar Christopher R
Role of oxidative stress in the induction of metallothionein-2A and heme oxygenase-1 gene expression by the antineoplastic agent gallium nitrate in human lymphoma cells.
Kolesar Jill M; Schelman William R; Geiger Peter G; Holen Kyle D; Traynor Anne M; Alberti Dona B; Thomas James P; Chitambar Christopher R; Wilding George; Antholine William E
Electron paramagnetic resonance study of peripheral blood mononuclear cells from patients with refractory solid tumors treated with Triapine.
Chitambar Christopher R; Purpi David P; Woodliff Jeffrey; Yang Meiying; Wereley Janine P
Development of gallium compounds for treatment of lymphoma: gallium maltolate, a novel hydroxypyrone gallium compound, induces apoptosis and circumvents lymphoma cell resistance to gallium nitrate.

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All Publications

2008: Yang Meiying; Chitambar Christopher R
Role of oxidative stress in the induction of metallothionein-2A and heme oxygenase-1 gene expression by the antineoplastic agent gallium nitrate in human lymphoma cells.
Free radical biology & medicine 2008;45(6):763-72.
2008: Kolesar Jill M; Schelman William R; Geiger Peter G; Holen Kyle D; Traynor Anne M; Alberti Dona B; Thomas James P; Chitambar Christopher R; Wilding George; Antholine William E
Electron paramagnetic resonance study of peripheral blood mononuclear cells from patients with refractory solid tumors treated with Triapine.
Journal of inorganic biochemistry 2008;102(4):693-8.
2007: Chitambar Christopher R; Purpi David P; Woodliff Jeffrey; Yang Meiying; Wereley Janine P
Development of gallium compounds for treatment of lymphoma: gallium maltolate, a novel hydroxypyrone gallium compound, induces apoptosis and circumvents lymphoma cell resistance to gallium nitrate.
The Journal of pharmacology and experimental therapeutics 2007;322(3):1228-36.
2007: Bommakanti Satya; Patil Amol; Eshoa Camellia; Chitambar Christopher R
Case reports: efalizumab-associated lymphoproliferative disease.
Journal of drugs in dermatology : JDD 2007;6(6):646-8.
2007: Yang Meiying; Kroft Steven H; Chitambar Christopher R
Gene expression analysis of gallium-resistant and gallium-sensitive lymphoma cells reveals a role for metal-responsive transcription factor-1, metallothionein-2A, and zinc transporter-1 in modulating the antineoplastic activity of gallium nitrate.
Molecular cancer therapeutics 2007;6(2):633-43.
2006: Chitambar Christopher R; Wereley Janine P; Matsuyama Shigemi
Gallium-induced cell death in lymphoma: role of transferrin receptor cycling, involvement of Bax and the mitochondria, and effects of proteasome inhibition.
Molecular cancer therapeutics 2006;5(11):2834-43.
2006: Chitambar Christopher R; Kotamraju Srigiridhar; Wereley Janine P
Expression of the hemochromatosis gene modulates the cytotoxicity of doxorubicin in breast cancer cells.
International journal of cancer. Journal international du cancer 2006;119(9):2200-4.
2006: Davies Neil P; Rahmanto Yohan Suryo; Chitambar Christopher R; Richardson Des R
Resistance to the antineoplastic agent gallium nitrate results in marked alterations in intracellular iron and gallium trafficking: identification of novel intermediates.
The Journal of pharmacology and experimental therapeutics 2006;317(1):153-62.
2005: Chitambar Christopher R
Cellular iron metabolism: mitochondria in the spotlight.
Blood 2005;105(5):1844-5.
2004: Chitambar Christopher R
Apoptotic mechanisms of gallium nitrate: basic and clinical investigations.
Oncology (Williston Park, N.Y.) 2004;18(13 Suppl 10):39-44.
2004: Chitambar Christopher R
Gallium compounds as antineoplastic agents.
Current opinion in oncology 2004;16(6):547-52.
2004: Chitambar Christopher R
Gallium nitrate for the treatment of non-Hodgkin's lymphoma.
Expert opinion on investigational drugs 2004;13(5):531-41.
2004: Kotamraju Srigiridhar; Tampo Yoshiko; Kalivendi Shasi V; Joseph Joy; Chitambar Christopher R; Kalyanaraman B
Nitric oxide mitigates peroxide-induced iron-signaling, oxidative damage, and apoptosis in endothelial cells: role of proteasomal function?
Archives of biochemistry and biophysics 2004;423(1):74-80.
2004: Kampalath Bal; Abed Nashwa; Chitambar Christopher R; Vantuinen Peter; Chakrabarty Gargi; Hanson Gerald; Rao R Nagarjun; Shidham Vinod B; Chang Chung-Che
Mantle cell lymphoma in lymph nodes with metastatic small cell carcinoma of lung: a diagnostic and treatment dilemma.
Leukemia & lymphoma 2004;45(2):409-14.
2004: Susnik Barbara; Jordi Rowe J; Redlich Philip N; Chitambar Christopher; Chang Chung-Che; Kampalath Bal
A unique collision tumor in breast: invasive ductal carcinoma and mucosa-associated lymphoid tissue lymphoma.
Archives of pathology & laboratory medicine 2004;128(1):99-101.
2004: Kotamraju Srigiridhar; Kalivendi Shasi V; Konorev Eugene; Chitambar Christopher R; Joseph Joy; Kalyanaraman B
Oxidant-induced iron signaling in Doxorubicin-mediated apoptosis.
Methods in enzymology 2004;378():362-82.
2003: Kotamraju Srigiridhar; Tampo Yoshiko; Keszler Agnes; Chitambar Christopher R; Joseph Joy; Haas Arthur L; Kalyanaraman B
Nitric oxide inhibits H2O2-induced transferrin receptor-dependent apoptosis in endothelial cells: Role of ubiquitin-proteasome pathway.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10653-8.
2003: Efferth Thomas; Sauerbrey Axel; Steinbach Daniel; Gebhart Erich; Drexler Hans-Günther; Miyachi Hayato; Chitambar Christopher R; Becker Cord-Michael; Zintl Felix; Humeny Andreas
Analysis of single nucleotide polymorphism C3435T of the multidrug resistance gene MDR1 in acute lymphoblastic leukemia.
International journal of oncology 2003;23(2):509-17.
2003: Chitambar Christopher R; Wereley Janine P
Expression of the hemochromatosis (HFE) gene modulates the cellular uptake of 67Ga.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2003;44(6):943-6.
2003: Chitambar Christopher R
Gallium nitrate revisited.
Seminars in oncology 2003;30(2 Suppl 5):1-4.
2003: Tampo Yoshiko; Kotamraju Srigiridhar; Chitambar Christopher R; Kalivendi Shasi V; Keszler Agnes; Joseph Joy; Kalyanaraman B
Oxidative stress-induced iron signaling is responsible for peroxide-dependent oxidation of dichlorodihydrofluorescein in endothelial cells: role of transferrin receptor-dependent iron uptake in apoptosis.
Circulation research 2003;92(1):56-63.
2002: Chang Chung-Che; Lorek Jennifer; Sabath Daniel E; Li Ying; Chitambar Christopher R; Logan Brent; Kampalath Bal; Cleveland Ronald P
Expression of MUM1/IRF4 correlates with clinical outcome in patients with B-cell chronic lymphocytic leukemia.
Blood 2002;100(13):4671-5.
2002: Chang Chung-Che; Bunyi-Teopengco Ellen; Eshoa Camellia; Chitambar Christopher R; Kampalath Bal
CD5+ T-cell/histiocyte-rich large B-cell lymphoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2002;15(10):1051-7.
2002: Efferth Thomas; Verdorfer Irmgard; Miyachi Hayato; Sauerbrey Axel; Drexler Hans G; Chitambar Christopher R; Haber Michelle; Gebhart Erich
Genomic imbalances in drug-resistant T-cell acute lymphoblastic CEM leukemia cell lines.
Blood cells, molecules & diseases 2002;29(1):1-13.
2002: Carroll Maria C; Fleming Matthew; Chitambar Christopher R; Neuburg Marcy
Diagnosis, workup, and prognosis of cutaneous metastases of unknown primary origin.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 2002;28(6):533-5.
2002: Kotamraju Srigiridhar; Chitambar Christopher R; Kalivendi Shasi V; Joseph Joy; Kalyanaraman B
Transferrin receptor-dependent iron uptake is responsible for doxorubicin-mediated apoptosis in endothelial cells: role of oxidant-induced iron signaling in apoptosis.
The Journal of biological chemistry 2002;277(19):17179-87.
2001: Green D A; Antholine W E; Wong S J; Richardson D R; Chitambar C R
Inhibition of malignant cell growth by 311, a novel iron chelator of the pyridoxal isonicotinoyl hydrazone class: effect on the R2 subunit of ribonucleotide reductase.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(11):3574-9.
2001: Chitambar C R; Wereley J P
Iron transport in a lymphoid cell line with the hemochromatosis C282Y mutation.
Blood 2001;97(9):2734-40.
2001: Efferth T; Dunstan H; Sauerbrey A; Miyachi H; Chitambar C R
The anti-malarial artesunate is also active against cancer.
International journal of oncology 2001;18(4):767-73.
2000: Chitambar C R; Wereley J P; Heiman T; Antholine W E; O'brien W J
Cellular adaptation to down-regulated iron transport into lymphoid leukaemic cells: effects on the expression of the gene for ribonucleotide reductase.
The Biochemical journal 2000;345 Pt 3():681-5.
1999: Wong S J; Myette M S; Wereley J P; Chitambar C R
Increased sensitivity of hydroxyurea-resistant leukemic cells to gemcitabine.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(2):439-43.
1998: Myette M S; Elford H L; Chitambar C R
Interaction of gallium nitrate with other inhibitors of ribonucleotide reductase: effects on the proliferation of human leukemic cells.
Cancer letters 1998;129(2):199-204.
1998: Chitambar C R; Wereley J P
Transferrin receptor-dependent and -independent iron transport in gallium-resistant human lymphoid leukemic cells.
Blood 1998;91(12):4686-93.
1998: Knorr G M; Chitambar C R
Gallium-pyridoxal isonicotinoyl hydrazone (Ga-PIH), a novel cytotoxic gallium complex. A comparative study with gallium nitrate.
Anticancer research 1998;18(3A):1733-7.
1997: Chitambar C R; Wereley J P
Resistance to the antitumor agent gallium nitrate in human leukemic cells is associated with decreased gallium/iron uptake, increased activity of iron regulatory protein-1, and decreased ferritin production.
The Journal of biological chemistry 1997;272(18):12151-7.
1997: Chitambar C R; Zahir S A; Ritch P S; Anderson T
Evaluation of continuous-infusion gallium nitrate and hydroxyurea in combination for the treatment of refractory non-Hodgkin's lymphoma.
American journal of clinical oncology 1997;20(2):173-8.
1997: Akansel G; Liu Y; Chitambar C R; Kitapci M T; Akansel S; Krasnow A Z; Isitman A T; Collier B D
Effect of gallium nitrate therapy on Ga-67 scintigraphic detection of lymphoma: case report.
Clinical nuclear medicine 1997;22(1):21-4.
1996: Drobyski W R; Ul-Haq R; Majewski D; Chitambar C R
Modulation of in vitro and in vivo T-cell responses by transferrin-gallium and gallium nitrate.
Blood 1996;88(8):3056-64.
1996: Chitambar C R; Boon P; Wereley J P
Evaluation of transferrin and gallium-pyridoxal isonicotinoyl hydrazone as potential therapeutic agents to overcome lymphoid leukemic cell resistance to gallium nitrate.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(6):1009-15.
1995: Chitambar C R; Wereley J P
Effect of hydroxyurea on cellular iron metabolism in human leukemic CCRF-CEM cells: changes in iron uptake and the regulation of transferrin receptor and ferritin gene expression following inhibition of DNA synthesis.
Cancer research 1995;55(19):4361-6.
1995: Haq R U; Wereley J P; Chitambar C R
Induction of apoptosis by iron deprivation in human leukemic CCRF-CEM cells.
Experimental hematology 1995;23(5):428-32.
1994: Whelan H T; Williams M B; Bajic D M; Flores R E; Schmidt M H; McAuliffe T L; Chitambar C R
Gallium nitrate delays the progression of microscopic disease in a human medulloblastoma murine model.
Pediatric neurology 1994;11(1):44-6.
1994: Chitambar C R; Wereley J P; Riaz-ul-Haq
Synergistic inhibition of T-lymphoblastic leukemic CCRF-CEM cell growth by gallium and recombinant human alpha-interferon through action on cellular iron uptake.
Cancer research 1994;54(12):3224-8.
1994: Whelan H T; Williams M B; Bajic D M; Segura A D; McAuliffe T L; Chitambar C R
Prevention of gallium toxicity by hyperhydration in treatment of medulloblastoma.
Pediatric neurology 1994;10(3):217-20.
1993: Ul-Haq R; Chitambar C R
Modulation of transferrin receptor mRNA by transferrin-gallium in human myeloid HL60 and lymphoid CCRF-CEM leukaemic cells.
The Biochemical journal 1993;294 ( Pt 3)():873-7.
1992: Narasimhan J; Antholine W E; Chitambar C R
Effect of gallium on the tyrosyl radical of the iron-dependent M2 subunit of ribonucleotide reductase.
Biochemical pharmacology 1992;44(12):2403-8.
1992: Whelan H T; Schmidt M H; Anderson G S; Chan B K; Hunter K; Kubacki D; Segura A D; Chitambar C R
Antineoplastic effects of gallium nitrate on human medulloblastoma in vivo.
Pediatric neurology 1992;8(5):323-7.
1992: Chitambar C R; Sax D
Regulatory effects of gallium on transferrin-independent iron uptake by human leukemic HL60 cells.
Blood 1992;80(2):505-11.
1991: Weissman D E; Janjan N A; Erickson B; Wilson F J; Greenberg M; Ritch P S; Anderson T; Hansen R M; Chitambar C R; Lawton C A
Twice-daily tapering dexamethasone treatment during cranial radiation for newly diagnosed brain metastases.
Journal of neuro-oncology 1991;11(3):235-9.
1991: Chitambar C R; Narasimhan J; Guy J; Sem D S; O'Brien W J
Inhibition of ribonucleotide reductase by gallium in murine leukemic L1210 cells.
Cancer research 1991;51(22):6199-201.
1991: Chitambar C R; Loebel A L; Noble N A
Shedding of transferrin receptor from rat reticulocytes during maturation in vitro: soluble transferrin receptor is derived from receptor shed in vesicles.
Blood 1991;78(9):2444-50.
1991: Lundberg J H; Hansen R M; Chitambar C R; Lawton C A; Gottlieb M; Anderson T; Ash R C
Allogeneic bone marrow transplantation for relapsed and refractory lymphoma using genotypically HLA-identical and alternative donors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1991;9(10):1848-59.
1991: Whelan H T; Przybylski C; Chitambar C R
Alteration of DNA synthesis in human brain tumor cells by gallium nitrate in vitro.
Pediatric neurology 1991;7(5):352-4.
1991: Narasimhan J; Antholine W E; Chitambar C R; Petering D H
Inhibition of iron uptake in HL60 cells by 2-formylpyridine monothiosemicarbazonato Cu(II).
Archives of biochemistry and biophysics 1991;289(2):393-8.
1991: Chitambar C R; Libnoch J A; Matthaeus W G; Ash R C; Ritch P S; Anderson T
Evaluation of continuous infusion low-dose 5-azacytidine in the treatment of myelodysplastic syndromes.
American journal of hematology 1991;37(2):100-4.
1991: Whelan H T; Przybylski C; Chitambar C R
Differential effects of gallium nitrate on proliferation of brain tumor cells in vitro.
Pediatric neurology 1991;7(1):23-7.
1991: Chitambar C R; Narasimhan J
Targeting iron-dependent DNA synthesis with gallium and transferrin-gallium.
Pathobiology : journal of immunopathology, molecular and cellular biology 1991;59(1):3-10.
1990: Lundberg J H; Chitambar C R
Interaction of gallium nitrate with fludarabine and iron chelators: effects on the proliferation of human leukemic HL60 cells.
Cancer research 1990;50(20):6466-70.
1990: Chitambar C R; Zivkovic-Gilgenbach Z
Influence of cellular iron status on the release of soluble transferrin receptor from human promyelocytic leukemic HL60 cells.
The Journal of laboratory and clinical medicine 1990;116(3):345-53.
1990: Chitambar C R; Zivkovic-Gilgenbach Z; Narasimhan J; Antholine W E
Development of drug resistance to gallium nitrate through modulation of cellular iron uptake.
Cancer research 1990;50(15):4468-72.
1990: Chitambar C R; Zivkovic-Gilgenbach Z
Role of the acidic receptosome in the uptake and retention of 67Ga by human leukemic HL60 cells.
Cancer research 1990;50(5):1484-7.
1990: Ash R C; Casper J T; Chitambar C R; Hansen R; Bunin N; Truitt R L; Lawton C; Murray K; Hunter J; Baxter-Lowe L A
Successful allogeneic transplantation of T-cell-depleted bone marrow from closely HLA-matched unrelated donors.
The New England journal of medicine 1990;322(8):485-94.
1989: Chitambar C R; Zivkovic Z
Release of soluble transferrin receptor from the surface of human leukemic HL60 cells.
Blood 1989;74(2):602-8.
1989: Chitambar C R; Craig A; Ash R C
Transferrin receptor-mediated suppression of in vitro hematopoiesis by transferrin-gallium.
Experimental hematology 1989;17(5):418-22.
1989: Chitambar C R; Seigneuret M C; Matthaeus W G; Lum L G
Modulation of lymphocyte proliferation and immunoglobulin production by transferrin-gallium.
Cancer research 1989;49(5):1125-9.
1988: Bunin N J; Casper J T; Chitambar C; Hunter J; Truitt R; Menitove J; Camitta B M; Ash R
Partially matched bone marrow transplantation in patients with myelodysplastic syndromes.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1988;6(12):1851-5.
1988: Chitambar C R; Matthaeus W G; Antholine W E; Graff K; O'Brien W J
Inhibition of leukemic HL60 cell growth by transferrin-gallium: effects on ribonucleotide reductase and demonstration of drug synergy with hydroxyurea.
Blood 1988;72(6):1930-6.
1988: Moynihan T; Hansen R; Anderson T; Quebbeman E; Beatty P; Ausman R; Ritch P; Chitambar C; Vukelich M
Continuous 5-fluorouracil infusion in advanced gastric carcinoma.
American journal of clinical oncology 1988;11(4):461-4.
1988: Bufill J A; Lum L G; Caya J G; Chitambar C R; Ritch P S; Anderson T; Ash R C
Pityrosporum folliculitis after bone marrow transplantation. Clinical observations in five patients.
Annals of internal medicine 1988;108(4):560-3.
1988: Hansen R; Quebbeman E; Ritch P; Chitambar C; Anderson T
Continuous 5-fluorouracil (5FU) infusion in carcinoma of the pancreas: a phase II study.
The American journal of the medical sciences 1988;295(2):91-3.
1987: Chitambar C R; Zivkovic Z
Uptake of gallium-67 by human leukemic cells: demonstration of transferrin receptor-dependent and transferrin-independent mechanisms.
Cancer research 1987;47(15):3929-34.
1987: Chitambar C R; Zivkovic Z
Inhibition of hemoglobin production by transferrin-gallium.
Blood 1987;69(1):144-9.

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