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Po Yee Chiu

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TOP 3
Phillip Y Lam; Hoi Yan Leung; Na Chen; Po Yee Chiu; Kam Ming Ko
Neuroprotection against oxidative injury by a nucleic acid-based health product (Squina DNA) through enhancing mitochondrial antioxidant status and functional capacity.
Na Chen; Po Yee Chiu; Hoi Yan Leung; Kam Ming Ko
Cytochrome P-450-catalyzed reactive oxygen species production mediates the (-)schisandrin B-induced glutathione and heat shock responses in H9c2 cardiomyocytes.
Pou Kuan Leong; Hoi Yan Leung; Po Yee Chiu; Kam Ming Ko
Cytochrome P450-catalysed reactive oxygen species production mediates the (-)schisandrin B-induced glutathione and heat shock responses in AML12 hepatocytes.

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All Publications

2012: Phillip Y Lam; Hoi Yan Leung; Na Chen; Po Yee Chiu; Kam Ming Ko
Neuroprotection against oxidative injury by a nucleic acid-based health product (Squina DNA) through enhancing mitochondrial antioxidant status and functional capacity.
Journal of medicinal food 2012;15(7):629-38.
2012: Na Chen; Po Yee Chiu; Hoi Yan Leung; Kam Ming Ko
Cytochrome P-450-catalyzed reactive oxygen species production mediates the (-)schisandrin B-induced glutathione and heat shock responses in H9c2 cardiomyocytes.
Indian journal of pharmacology 2012;44(2):204-9.
2012: Pou Kuan Leong; Hoi Yan Leung; Po Yee Chiu; Kam Ming Ko
Cytochrome P450-catalysed reactive oxygen species production mediates the (-)schisandrin B-induced glutathione and heat shock responses in AML12 hepatocytes.
Cell biology international 2012;36(3):321-6.
2012: Pou Kuan Leong; Po Yee Chiu; Kam Ming Ko
Prooxidant-induced glutathione antioxidant response in vitro and in vivo: a comparative study between schisandrin B and curcumin.
Biological & pharmaceutical bulletin 2012;35(4):464-72.
2011: Po Yee Chiu; Na Chen; Philip Y Lam; Pou Kuan Leong; Hoi Yan Leung; Sze Man Wong; Limin Zhou; Zhong Zuo; Kam Ming Ko
Acute treatment with Danshen-Gegen decoction protects the myocardium against ischemia/reperfusion injury via the redox-sensitive PKCɛ/mK(ATP) pathway in rats.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2011;18(11):916-25.
2011: Po Yee Chiu; Philip Y Lam; Chung Wai Yan; Kam Ming Ko
Schisandrin B protects against solar irradiation-induced oxidative injury in BJ human fibroblasts.
Fitoterapia 2011;82(4):682-91.
2011: Pou Kuan Leong; Po Yee Chiu; Na Chen; Hoiyan Leung; Kam Ming Ko
Schisandrin B elicits a glutathione antioxidant response and protects against apoptosis via the redox-sensitive ERK/Nrf2 pathway in AML12 hepatocytes.
Free radical research 2011;45(4):483-95.
2011: Po Yee Chiu; Sze Man Wong; Hoi Yan Leung; Pou Kuan Leong; Na Chen; Limin Zhou; Zhong Zuo; Philip Y Lam; Kam Ming Ko
Long-term treatment with danshen-gegen decoction protects the myocardium against ischemia/reperfusion injury via the redox-sensitive protein kinase C-ε/mK(ATP) pathway in rats.
Rejuvenation research 2011;14(2):173-84.
2011: Po Yee Chiu; Na Chen; Po Kuan Leong; Hoi Yan Leung; Kam Ming Ko
Schisandrin B elicits a glutathione antioxidant response and protects against apoptosis via the redox-sensitive ERK/Nrf2 pathway in H9c2 cells.
Molecular and cellular biochemistry 2011;350(1-2):237-50.
2011: Philip Y Lam; Chung Wai Yan; Po Yee Chiu; Hoi Yan Leung; Kam Ming Ko
Schisandrin B protects against solar irradiation-induced oxidative stress in rat skin tissue.
Fitoterapia 2011;82(3):393-400.
2011: Po Yee Chiu; Philip Y Lam; Hoi Yan Leung; Pou Kuan Leong; Chung Wah Ma; Qing Tao Tang; Kam Ming Ko
Co-treatment with Shengmai San-derived herbal product ameliorates chronic ethanol-induced liver damage in rats.
Rejuvenation research 2011;14(1):17-23.
2011: Sze Man Wong; Po Yee Chiu; Hoi Yan Leung; Limin Zhou; Zhong Zuo; Philip Y Lam; Kam Ming Ko
Myocardial post-conditioning with Danshen-Gegen decoction protects against isoproterenol-induced myocardial injury via a PKCε/mKATP-mediated pathway in rats.
Chinese medicine 2011;6(1):7.
2010: Philip Y Lam; Po Yee Chiu; Hoi Yan Leung; Na Chen; Pou Kuan Leong; Kam Ming Ko
Schisandrin B co-treatment ameliorates the impairment on mitochondrial antioxidant status in various tissues of long-term ethanol treated rats.
Fitoterapia 2010;81(8):1239-45.
2010: Kam Ming Ko; Po Yee Chiu; Hoi Yan Leung; Ada Hoi Ling Siu; Na Chen; Eriol Pou Kwan Leong; Michel K T Poon
Long-term dietary supplementation with a yang-invigorating Chinese herbal formula increases lifespan and mitigates age-associated declines in mitochondrial antioxidant status and functional ability of various tissues in male and female C57BL/6J mice.
Rejuvenation research 2010;13(2-3):168-71.
2009: Po Yee Chiu; Ka Fai Luk; Hoi Yan Leung; Ka Ming Ng; Kam Ming Ko
Schisandrin B stereoisomers protect against hypoxia/reoxygenation-induced apoptosis and associated changes in the Ca(2+)-induced mitochondrial permeability transition and mitochondrial membrane potential in AML12 hepatocytes.
Phytotherapy research : PTR 2009;23(11):1592-602.
2008: Na Chen; Po Yee Chiu; Kam Ming Ko
Schisandrin B enhances cerebral mitochondrial antioxidant status and structural integrity, and protects against cerebral ischemia/reperfusion injury in rats.
Biological & pharmaceutical bulletin 2008;31(7):1387-91.
2008: Po Yee Chiu; Ka Fai Luk; Hoi Yan Leung; Ka Ming Ng; Kam Ming Ko
Schisandrin B stereoisomers protect against hypoxia/reoxygenation-induced apoptosis and inhibit associated changes in Ca2+-induced mitochondrial permeability transition and mitochondrial membrane potential in H9c2 cardiomyocytes.
Life sciences 2008;82(21-22):1092-101.
2008: Po Yee Chiu; Hoi Yan Leung; Kam Ming Ko
Schisandrin B Enhances Renal Mitochondrial Antioxidant Status, Functional and Structural Integrity, and Protects against Gentamicin-Induced Nephrotoxicity in Rats.
Biological & pharmaceutical bulletin 2008;31(4):602-5.
2008: Po Yee Chiu; Hoi Yan Leung; Ada Hoi Ling Siu; Na Chen; Michel K T Poon; Kam Ming Ko
Long-term treatment with a Yang-invigorating Chinese herbal formula produces generalized tissue protection against oxidative damage in rats.
Rejuvenation research 2008;11(1):43-62.
2008: Kam Ming Ko; Na Chen; Hoi Yan Leung; Eriol P K Leong; Michel K T Poon; Po Yee Chiu
Long-term schisandrin B treatment mitigates age-related impairments in mitochondrial antioxidant status and functional ability in various tissues, and improves the survival of aging C57BL/6J mice.
BioFactors (Oxford, England) 2008;34(4):331-42.
2008: Michel K T Poon; Po Yee Chiu; Hoi Yan Leung; Ada H Y Siu; Kam Ming Ko
A 'Yang-Invigorating' Chinese herbal formula protects against gentamicin-induced nephrotoxicity in rats.
Phytotherapy research : PTR 2008;22(1):131-3.
2007: Po Yee Chiu; Hoi Yan Leung; Ada H Y Siu; Michel K T Poon; Kam Ming Ko
Schisandrin B decreases the sensitivity of mitochondria to calcium ion-induced permeability transition and protects against ischemia-reperfusion injury in rat hearts.
Acta pharmacologica Sinica 2007;28(10):1559-65.
2007: Po Yee Chiu; Hoi Yan Leung; Ada Hoi Ling Siu; Michel K T Poon; Kam Ming Ko
Schisandrin B decreases the sensitivity of mitochondria to calcium ion-induced permeability transition and protects against carbon tetrachloride toxicity in mouse livers.
Biological & pharmaceutical bulletin 2007;30(6):1108-12.
2007: Po Yee Chiu; Hoi Yan Leung; Ada H Y Siu; Michel K T Poon; Tina T X Dong; Karl W K Tsim; Kam Ming Ko
Dang-Gui Buxue Tang protects against oxidant injury by enhancing cellular glutathione in H9c2 cells: role of glutathione synthesis and regeneration.
Planta medica 2007;73(2):134-41.
2006: Po Yee Chiu; Hoi Yan Leung; Michel K T Poon; Susanna S T Lee; Kam Ming Ko
Schisandrin B induced antioxidant response is partly mediated by cytochrome P-4502E1 catalyzed reaction in mouse liver.
Molecular and cellular biochemistry 2006;293(1-2):87-92.
2006: Kam Ming Ko; T Y Y Leon; Duncan H F Mak; Po Yee Chiu; Y Du; Michel K T Poon
A characteristic pharmacological action of 'Yang-invigorating' Chinese tonifying herbs: enhancement of myocardial ATP-generation capacity.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2006;13(9-10):636-42.
2006: Po Yee Chiu; Hoi Yan Leung; Michel K T Poon; Duncan H F Mak; Kam Ming Ko
(-)Schisandrin B is more potent than its enantiomer in enhancing cellular glutathione and heat shock protein production as well as protecting against oxidant injury in H9c2 cardiomyocytes.
Molecular and cellular biochemistry 2006;289(1-2):185-91.
2006: Po Yee Chiu; Hoi Yan Leung; Michel K T Poon; Kam Ming Ko
Chronic schisandrin B treatment improves mitochondrial antioxidant status and tissue heat shock protein production in various tissues of young adult and middle-aged rats.
Biogerontology 2006;7(4):199-210.
2006: Duncan H F Mak; Po Yee Chiu; Tina T X Dong; Karl W K Tsim; Kam Ming Ko
Dang-Gui Buxue Tang produces a more potent cardioprotective effect than its component herb extracts and enhances glutathione status in rat heart mitochondria and erythrocytes.
Phytotherapy research : PTR 2006;20(7):561-7.
2006: Po Yee Chiu; Kam Ming Ko
Schisandrin B-induced increase in cellular glutathione level and protection against oxidant injury are mediated by the enhancement of glutathione synthesis and regeneration in AML12 and H9c2 cells.
BioFactors (Oxford, England) 2006;26(4):221-30.
2006: Po Yee Chiu; Hoi Yan Leung; Michel K T Poon; Duncan H F Mak; Kam Ming Ko
Effects of schisandrin B enantiomers on cellular glutathione and menadione toxicity in AML12 hepatocytes.
Pharmacology 2006;77(2):63-70.
2006: Kam Ming Ko; Po Yee Chiu
Biochemical basis of the "Qi-invigorating" action of Schisandra berry (wu-wei-zi) in Chinese medicine.
The American journal of Chinese medicine 2006;34(2):171-6.
2005: Po Yee Chiu; Duncan H F Mak; Michel K T Poon; Kam Ming Ko
Role of cytochrome P-450 in schisandrin B-induced antioxidant and heat shock responses in mouse liver.
Life sciences 2005;77(23):2887-95.
2005: Kam Ming Ko; Po Yee Chiu
Structural determinants of schisandrin B which enhance mitochondrial functional ability and glutathione status as well as heat shock protein expression in rat hearts and H9c2 cells.
Molecular and cellular biochemistry 2005;276(1-2):227-34.
2005: Hoi Yan Leung; Po Yee Chiu; Michel K T Poon; Kam Ming Ko
A yang-invigorating Chinese herbal formula enhances mitochondrial functional ability and antioxidant capacity in various tissues of male and female rats.
Rejuvenation research 2005;8(4):238-47.
2004: Kai Ming Siu; Duncan H F Mak; Po Yee Chiu; Michel K T Poon; Y Du; Kam Ming Ko
Pharmacological basis of 'Yin-nourishing' and 'Yang-invigorating' actions of Cordyceps, a Chinese tonifying herb.
Life sciences 2004;76(4):385-95.
2004: Po Yee Chiu; Kam Ming Ko
Schisandrin B protects myocardial ischemia-reperfusion injury partly by inducing Hsp25 and Hsp70 expression in rats.
Molecular and cellular biochemistry 2004;266(1-2):139-44.
2004: Duncan H F Mak; Po Yee Chiu; Michel K T Poon; T T L Ng; Y K Chung; B Y H Lam; Y Du; Kam Ming Ko
A yang-promoting Chinese herbal suppository preparation enhances the antioxidant status of red cells in male human subjects.
Phytotherapy research : PTR 2004;18(7):525-30.
2004: Kam Ming Ko; Duncan H F Mak; Po Yee Chiu; Michel K T Poon
Pharmacological basis of 'Yang-invigoration' in Chinese medicine.
Trends in pharmacological sciences 2004;25(1):3-6.
2003: Michel K T Poon; Po Yee Chiu; Duncan H F Mak; Kam Ming Ko
Metformin protects against carbon tetrachloride hepatotoxicity in mice.
Journal of pharmacological sciences 2003;93(4):501-4.
2003: Po Yee Chiu; Man Ho Tang; Duncan H F Mak; Michel K T Poon; Kam Ming Ko
Hepatoprotective mechanism of schisandrin B: role of mitochondrial glutathione antioxidant status and heat shock proteins.
Free radical biology & medicine 2003;35(4):368-80.
2003: Po Yee Chiu; Kam Ming Ko
Time-dependent enhancement in mitochondrial glutathione status and ATP generation capacity by schisandrin B treatment decreases the susceptibility of rat hearts to ischemia-reperfusion injury.
BioFactors (Oxford, England) 2003;19(1-2):43-51.
2003: Man Ho Tang; Po Yee Chiu; Kam Ming Ko
Hepatoprotective action of schisandrin B against carbon tetrachloride toxicity was mediated by both enhancement of mitochondrial glutathione status and induction of heat shock proteins in mice.
BioFactors (Oxford, England) 2003;19(1-2):33-42.
2002: Po Yee Chiu; Duncan H F Mak; Michel K T Poon; Kam Ming Ko
In vivo antioxidant action of a lignan-enriched extract of Schisandra fruit and an anthraquinone-containing extract of Polygonum root in comparison with schisandrin B and emodin.
Planta medica 2002;68(11):951-6.