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Paul Alewood

Research Profile

Chemicals & Drugs

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Andreas Brust; Nicholas R Casewell; Paul F Alewood; Agostinho Antunes; Iwan Hendrikx; Wayne C Hodgson; Timothy N W Jackson; Glenn F King; Ivan Koludarov; Richard J Lewis; Kartik Sunagar; Eivind A B Undheim; Irina Vetter; Daryl C Yang; Bryan G Fry
Differential evolution and neofunctionalization of snake venom metalloprotease domains.
Artin Ghassemian; Richard J Lewis; Robert C Reid; Ching-I Anderson Wang; Mei-Kwan Yau; Paul F Alewood; David P Fairlie; Thomas Durek
Efficient chemical synthesis of human complement protein C3a.
Andreas Brust; Nicholas R Casewell; Paul F Alewood; Agostinho Antunes; Iwan Hendrikx; Wayne C Hodgson; Timothy N W Jackson; Glenn F King; Ivan Koludarov; Richard J Lewis; Kartik Sunagar; Eivind A B Undheim; Irina Vetter; Dary C Yang; Bryan Fry
Differential evolution and neofunctionalization of snake venom metalloprotease domains.

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All Publications

2013: Andreas Brust; Nicholas R Casewell; Paul F Alewood; Agostinho Antunes; Iwan Hendrikx; Wayne C Hodgson; Timothy N W Jackson; Glenn F King; Ivan Koludarov; Richard J Lewis; Kartik Sunagar; Eivind A B Undheim; Irina Vetter; Daryl C Yang; Bryan G Fry
Differential evolution and neofunctionalization of snake venom metalloprotease domains.
Molecular & cellular proteomics : MCP 2013;12(5):1488.
2013: Artin Ghassemian; Richard J Lewis; Robert C Reid; Ching-I Anderson Wang; Mei-Kwan Yau; Paul F Alewood; David P Fairlie; Thomas Durek
Efficient chemical synthesis of human complement protein C3a.
Chemical communications (Cambridge, England) 2013;49(23):2356-8.
2013: Andreas Brust; Nicholas R Casewell; Paul F Alewood; Agostinho Antunes; Iwan Hendrikx; Wayne C Hodgson; Timothy N W Jackson; Glenn F King; Ivan Koludarov; Richard J Lewis; Kartik Sunagar; Eivind A B Undheim; Irina Vetter; Dary C Yang; Bryan Fry
Differential evolution and neofunctionalization of snake venom metalloprotease domains.
Molecular & cellular proteomics : MCP 2013;12(3):651-63.
2013: sebastien dutertre; Ai-hua Jin; Alun Jones; Quentin Kaas; Paul F Alewood; Richard J Lewis
Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom.
Molecular & cellular proteomics : MCP 2013;12(2):312-29.
2012: Aline Dantas de Araujo; Glenn F King; Mehdi Mobli; Paul F Alewood
Cyclization of peptides by using selenolanthionine bridges.
Angewandte Chemie (International ed. in English) 2012;51(41):10298-302.
2012: Irina Vetter; David J Adams; Paul F Alewood; Zoltan Dekan; Oliver Knapp; Richard J Lewis
Isolation, characterization and total regioselective synthesis of the novel μO-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels.
Biochemical pharmacology 2012;84(4):540-8.
2012: Zoltan Dekan; Richard J Lewis; Ching-I A Wang; Robert K Andrews; Paul F Alewood
Conotoxin engineering: dual pharmacophoric noradrenaline transport inhibitor/integrin binding peptide with improved stability.
Organic & biomolecular chemistry 2012;10(30):5791-4.
2012: Jonas E Jensen; Glenn F King; Mehdi Mobli; Paul F Alewood; Andreas Brust; Lachlan D Rash
Cyclisation increases the stability of the sea anemone peptide APETx2 but decreases its activity at acid-sensing ion channel 3.
Marine drugs 2012;10(7):1511-27.
2012: Irina Vetter; Joshua S Wingerd; Christine A Mozar; Paul F Alewood; MacDonald J Christie; Thomas Durek; Richard J Lewis
Characterisation of Na(v) types endogenously expressed in human SH-SY5Y neuroblastoma cells.
Biochemical pharmacology 2012;83(11):1562-71.
2012: I A Napier; B K Rycroft; David J Adams; Paul F Alewood; A H Jin; H Klimis; Leonid Motin; MacDonald J Christie
Intrathecal α-conotoxins Vc1.1, AuIB and MII acting on distinct nicotinic receptor subtypes reverse signs of neuropathic pain.
Neuropharmacology 2012;62(7):2202-7.
2012: Kimberley A Beaumont; Eric Chai; Yan Yan Liu; Glenn L Millhauser; Mira P Patel; Darren J Smit; Jennifer J Smith; Paul F Alewood; Richard A Sturm
Melanocortin-1 receptor-mediated signalling pathways activated by NDP-MSH and HBD3 ligands.
Pigment cell & melanoma research 2012;25(3):370-4.
2012: S Vink; G A Head; A H Jin; K J Poth; Paul F Alewood
Natriuretic peptide drug leads from snake venom.
Toxicon : official journal of the International Society on Toxinology 2012;59(4):434-45.
2012: Claudia U Hjørringgaard; Andreas Brust; Paul F Alewood
Evaluation of COMU as a coupling reagent for in situ neutralization Boc solid phase peptide synthesis.
Journal of peptide science : an official publication of the European Peptide Society 2012;18(3):199-207.
2012: Jennifer J Smith; Alun Jones; Paul F Alewood
Mass landscapes of seven scorpion species: The first analyses of Australian species with 1,5-DAN matrix.
Journal of venom research 2012;3():7-14.
2012: Christina I Schroeder; Linda Thomas; Denise A Adams; Paul F Alewood; Richard J Lewis; Marion L Loughnan; Katherine J Nielsen; David J Craik
Effects of Lys2 to Ala2 substitutions on the structure and potency of ω-conotoxins MVIIA and CVID.
Biopolymers 2012;98(4):345-56.
2012: Vincent Lavergne; Ryan J Taft; Paul F Alewood
Cysteine-rich mini-proteins in human biology.
Current topics in medicinal chemistry 2012;12(14):1514-33.
2012: Christina I Schroeder; Linda Thomas; Denise Adams; Paul F Alewood; Richard J Lewis
N- and C-terminal extensions of μ-conotoxins increase potency and selectivity for neuronal sodium channels.
Biopolymers 2012;98(2):161-5.
2011: Aline Dantas de Araujo; Stephen B H Kent; Jens Buchardt; Caspar Christensen; Paul F Alewood
Synthesis of tripeptide mimetics based on dihydroquinolinone and benzoxazinone scaffolds.
Chemistry (Weinheim an der Bergstrasse, Germany) 2011;17(50):13983-6.
2011: Mehdi Mobli; David Morgenstern; Paul F Alewood; Glenn F King; Markus Muttenthaler
Site-specific pK(a) determination of selenocysteine residues in selenovasopressin by using 77Se NMR spectroscopy.
Angewandte Chemie (International ed. in English) 2011;50(50):11952-5.
2011: Thomas Durek; Paul F Alewood
Preformed selenoesters enable rapid native chemical ligation at intractable sites.
Angewandte Chemie (International ed. in English) 2011;50(50):12042-5.
2011: Zoltan Dekan; Richard J Lewis; Irina Vetter; David J Craik; Norelle L Daly; Paul F Alewood
α-Conotoxin ImI incorporating stable cystathionine bridges maintains full potency and identical three-dimensional structure.
Journal of the American Chemical Society 2011;133(40):15866-9.
2011: Gene Wijffels; Paul F Alewood; Susan J Briscoe; Jens Buchardt; Caspar Christensen; Brian P Dalrymple; Nicholas E Dixon; V Chandana Epa; Albert Hofmann; Philip A Jennings; Wynona M Johnson; Andris J Liepa; Aaron J Oakley; Mitchell Polley; Pavel Prosselkov; Kathleen Turner; David A Winkler
Binding inhibitors of the bacterial sliding clamp by design.
Journal of medicinal chemistry 2011;54(13):4831-8.
2011: Aline Dantas de Araujo; Gene Hopping; Melissa Moretta; Simon T Nevin; Brid P Callaghan; MacDonald J Christie; David J Craik; Norelle L Daly; David J Adams; Paul F Alewood
Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding.
Angewandte Chemie (International ed. in English) 2011;50(29):6527-9.
2011: Jennifer J Smith; Justine M Hill; Glenn F King; Michelle J Little; Graham M Nicholson; Paul F Alewood
Unique scorpion toxin with a putative ancestral fold provides insight into evolution of the inhibitor cystine knot motif.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(26):10478-83.
2011: Kimberley A Beaumont; Shu S Wong; Stephen A Ainger; Yan Yan Liu; Mira P Patel; Glenn L Millhauser; Jennifer J Smith; Paul F Alewood; J Helen Leonard; Richard A Sturm
Melanocortin MC₁ receptor in human genetics and model systems.
European journal of pharmacology 2011;660(1):103-10.
2011: John W Holland; Rajesh Gupta; Hilton C Deeth; Paul F Alewood
Proteomic analysis of temperature-dependent changes in stored UHT milk.
Journal of agricultural and food chemistry 2011;59(5):1837-46.
2011: Lachlan D Rash; Rodrigo A V Morales; Simone Vink; Paul F Alewood
De novo sequencing of peptides from the parotid secretion of the cane toad, Bufo marinus (Rhinella marina).
Toxicon : official journal of the International Society on Toxinology 2011;57(2):208-16.
2011: Irina Vetter; Jasmine L Davis; Lachlan D Rash; Raveendra Anangi; Mehdi Mobli; Paul F Alewood; Richard J Lewis; Glenn F King
Venomics: a new paradigm for natural products-based drug discovery.
Amino acids 2011;40(1):15-28.
2010: Markus Muttenthaler; Asa Andersson; Aline D de Araujo; Zoltan Dekan; Richard J Lewis; Paul F Alewood
Modulating oxytocin activity and plasma stability by disulfide bond engineering.
Journal of medicinal chemistry 2010;53(24):8585-96.
2010: Dianne Alewood; Gene Hopping; Andreas Brust; Robert C Reid; Paul F Alewood
Benzhydrylamine linker grafting: a strategy for the improved synthesis of C-terminal peptide amides.
Journal of peptide science : an official publication of the European Peptide Society 2010;16(10):551-7.
2010: Rodrigo A V Morales; Norelle L Daly; Irina Vetter; Mehdi Mobli; Ian A Napier; David J Craik; Richard J Lewis; MacDonald J Christie; Glenn F King; Paul F Alewood; Thomas Durek
Chemical synthesis and structure of the prokineticin Bv8.
Chembiochem : a European journal of chemical biology 2010;11(13):1882-8.
2010: Anton A Grishin; Ching-I A Wang; Markus Muttenthaler; Paul F Alewood; Richard J Lewis; David J Adams
Alpha-conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of alpha3beta4 nicotinic acetylcholine receptors.
The Journal of biological chemistry 2010;285(29):22254-63.
2010: Sulan Luo; Kalyana Bharati Akondi; Dongting Zhangsun; Yong Wu; Xiaopeng Zhu; Yuanyan Hu; Sean Christensen; Cheryl Dowell; Norelle L Daly; David J Craik; Ching-I Anderson Wang; Richard J Lewis; Paul F Alewood; J Michael McIntosh
Atypical alpha-conotoxin LtIA from Conus litteratus targets a novel microsite of the alpha3beta2 nicotinic receptor.
The Journal of biological chemistry 2010;285(16):12355-66.
2010: Markus Muttenthaler; Simon T Nevin; Anton A Grishin; Shyuan Thieu Ngo; Peng T Choy; Norelle L Daly; Shu-Hong Hu; Christopher J Armishaw; Ching-I A Wang; Richard J Lewis; Jennifer L Martin; Peter G Noakes; David J Craik; David J Adams; Paul F Alewood
Solving the alpha-conotoxin folding problem: efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antagonists.
Journal of the American Chemical Society 2010;132(10):3514-22.
2010: G Berecki; Leonid Motin; A Haythornthwaite; S Vink; P Bansal; R Drinkwater; C I Wang; M Moretta; Richard J Lewis; Paul F Alewood; M J Christie; D J Adams
Analgesic (omega)-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels.
Molecular pharmacology 2010;77(2):139-48.
2010: Markus Muttenthaler; Yesica Garcia Ramos; Debby Feytens; Aline D de Araujo; Paul F Alewood
p-Nitrobenzyl protection for cysteine and selenocysteine: a more stable alternative to the acetamidomethyl group.
Biopolymers 2010;94(4):423-32.
2010: Christopher J Armishaw; Julie L Dutton; David J Craik; Paul F Alewood
Establishing regiocontrol of disulfide bond isomers of alpha-conotoxin ImI via the synthesis of N-to-C cyclic analogs.
Biopolymers 2010;94(3):307-13.
2009: Guilhem Pages; Allan M Torres; Pengchu Ju; Paramjit S Bansal; Paul F Alewood; Philip W Kuchel; Jamie I Vandenberg
Structure of the pore-helix of the hERG K(+) channel.
European biophysics journal : EBJ 2009;39(1):111-20.
2009: Andreas Brust; Elka Palant; Daniel E Croker; Barbara Colless; Roger Drinkwater; Brad Patterson; Christina I Schroeder; David Wilson; Carsten Nielsen; Maree T Smith; Dianne Alewood; Paul F Alewood; Richard J Lewis
chi-Conopeptide pharmacophore development: toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain.
Journal of medicinal chemistry 2009;52(22):6991-7002.
2009: Jonas E Jensen; Thomas Durek; Paul F Alewood; David J Adams; Glenn F King; Lachlan D Rash
Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3.
Toxicon : official journal of the International Society on Toxinology 2009;54(1):56-61.
2009: Beatrix Ueberheide; David Fenyö; Paul F Alewood; Brian T Chait
Rapid sensitive analysis of cysteine rich peptide venom components.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(17):6910-5.
2009: Emma L Millard; Simon T Nevin; Marion L Loughnan; Annette Nicke; Richard J Clark; Paul F Alewood; Richard J Lewis; David J Adams; David J Craik; Norelle L Daly
Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-Conotoxin GID and analogues.
The Journal of biological chemistry 2009;284(8):4944-51.
2009: Mehdi Mobli; Aline Dantas de Araújo; Lynette K Lambert; Gregory K Pierens; Monique J Windley; Graham M Nicholson; Paul F Alewood; Glenn F King
Direct visualization of disulfide bonds through diselenide proxies using 77Se NMR spectroscopy.
Angewandte Chemie (International ed. in English) 2009;48(49):9312-4.
2009: Andrea J Vernall; Peter Cassidy; Paul F Alewood
A single alpha-helical turn stabilized by replacement of an internal hydrogen bond with a covalent ethylene bridge.
Angewandte Chemie (International ed. in English) 2009;48(31):5675-8.
2008: Markus Muttenthaler; Paul F Alewood
Selenopeptide chemistry.
Journal of peptide science : an official publication of the European Peptide Society 2008;14(12):1223-39.
2008: Aaron G Poth; Hilton C Deeth; Paul F Alewood; John W Holland
Analysis of the human casein phosphoproteome by 2-D electrophoresis and MALDI-TOF/TOF MS reveals new phosphoforms.
Journal of proteome research 2008;7(11):5017-27.
2008: Ai-Hua Jin; Norelle L Daly; Simon T Nevin; Ching-I A Wang; sebastien dutertre; Richard J Lewis; David J Adams; David J Craik; Paul F Alewood
Molecular engineering of conotoxins: the importance of loop size to alpha-conotoxin structure and function.
Journal of medicinal chemistry 2008;51(18):5575-84.
2008: Julita S Imperial; Ping Chen; Annett Sporning; Heinrich Terlau; Norelle L Daly; David J Craik; Paul F Alewood; Baldomero M Olivera
Tyrosine-rich conopeptides affect voltage-gated K+ channels.
The Journal of biological chemistry 2008;283(34):23026-32.
2008: Christina I Schroeder; Jenny Ekberg; Katherine J Nielsen; Denise Adams; Marion L Loughnan; Linda Thomas; David J Adams; Paul F Alewood; Richard J Lewis
Neuronally micro-conotoxins from Conus striatus utilize an alpha-helical motif to target mammalian sodium channels.
The Journal of biological chemistry 2008;283(31):21621-8.
2008: John W Holland; Hilton C Deeth; Paul F Alewood
Analysis of disulphide linkages in bovine kappa-casein oligomers using two-dimensional electrophoresis.
Electrophoresis 2008;29(11):2402-10.
2008: Wei Xing Yan; Chris Armishaw; Jesse Goyette; Z Yang; Hong Cai; Paul F Alewood; Carolyn L Geczy
Mast cell and monocyte recruitment by S100A12 and its hinge domain.
The Journal of biological chemistry 2008;283(19):13035-43.
2008: Joel D A Tyndall; Leonard K Pattenden; Robert C Reid; Shu-Hong Hu; Dianne Alewood; Paul F Alewood; Terry Walsh; David P Fairlie; Jennifer L Martin
Crystal structures of highly constrained substrate and hydrolysis products bound to HIV-1 protease. Implications for the catalytic mechanism.
Biochemistry 2008;47(12):3736-44.
2008: sebastien dutertre; Daniel Croker; Norelle L Daly; Asa Andersson; Markus Muttenthaler; Natalie G Lumsden; David J Craik; Paul F Alewood; gilles guillon; Richard J Lewis
Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptides.
The Journal of biological chemistry 2008;283(11):7100-8.
2007: Joanne T Blanchfield; Oliver P Gallagher; Cecile Cros; Richard J Lewis; Paul F Alewood; Istvan Toth
Oral absorption and in vivo biodistribution of alpha-conotoxin MII and a lipidic analogue.
Biochemical and biophysical research communications 2007;361(1):97-102.
2007: sebastien dutertre; Chris Ulens; Regina Büttner; Alexander Fish; René Van Elk; Yvonne Kendel; Gene Hopping; Paul F Alewood; Christina Schroeder; Annette Nicke; August B Smit; Titia K Sixma; Richard J Lewis
AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity.
The EMBO journal 2007;26(16):3858-67.
2007: Catherine F Latham; Shu-Hong Hu; Christine L Gee; Christopher J Armishaw; Paul F Alewood; David E James; Jennifer L Martin
Crystallization and preliminary X-ray diffraction of the Munc18c-syntaxin4 (1-29) complex.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 6):524-8.
2007: Indu R Chandrashekaran; Shenggen Yao; Chunxiao C Wang; Paramjit S Bansal; Paul F Alewood; Briony E Forbes; John C Wallace; Leon A Bach; Raymond S Norton
The N-terminal subdomain of insulin-like growth factor (IGF) binding protein 6. Structure and interaction with IGFs.
Biochemistry 2007;46(11):3065-74.
2007: Richard J Lewis; Christina I Schroeder; Jenny Ekberg; Katherine J Nielsen; Marion L Loughnan; Linda Thomas; Denise A Adams; Roger Drinkwater; David J Adams; Paul F Alewood
Isolation and structure-activity of mu-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels.
Molecular pharmacology 2007;71(3):676-85.
2007: Dileep G Nair; Bryan Fry; Paul F Alewood; Prakash P Kumar; R Manjunatha Kini
Antimicrobial activity of omwaprin, a new member of the waprin family of snake venom proteins.
The Biochemical journal 2007;402(1):93-104.
2007: Ai-Hua Jin; Hemma Brandstaetter; Simon T Nevin; Chia Chia Tan; Richard J Clark; David J Adams; Paul F Alewood; David J Craik; Norelle L Daly
Structure of alpha-conotoxin BuIA: influences of disulfide connectivity on structural dynamics.
BMC structural biology 2007;7():28.
2007: Zheng Yang; Wei Xing Yan; Hong Cai; Nicodemus Tedla; Chris Armishaw; Nick Di Girolamo; Hong Wei Wang; Taline Hampartzoumian; Jodie L Simpson; Peter G Gibson; John Hunt; Prue Hart; J Margaret Hughes; Michael A Perry; Paul F Alewood; Carolyn L Geczy
S100A12 provokes mast cell activation: a potential amplification pathway in asthma and innate immunity.
The Journal of allergy and clinical immunology 2007;119(1):106-14.
2007: Allan M Torres; M Tsampazi; Eleanor C Kennett; Katherine Belov; Dominic P Geraghty; Paramjit S Bansal; Paul F Alewood; Philip W Kuchel
Characterization and isolation of L-to-D-amino-acid-residue isomerase from platypus venom.
Amino acids 2007;32(1):63-8.
2006: Liam St Pierre; Simone Flight; Paul P Masci; Kim J Hanchard; Richard J Lewis; Paul F Alewood; John de Jersey; Martin F Lavin
Cloning and characterisation of natriuretic peptides from the venom glands of Australian elapids.
Biochimie 2006;88(12):1923-31.
2006: Erica Lovelace; Christopher J Armishaw; Michelle Colgrave; Maria E Wahlstrom; Paul F Alewood; Norelle L Daly; David J Craik
Cyclic MrIA: a stable and potent cyclic conotoxin with a novel topological fold that targets the norepinephrine transporter.
Journal of medicinal chemistry 2006;49(22):6561-8.
2006: Catherine F Latham; Jamie A Lopez; Shu-Hong Hu; Christine L Gee; Elizabeth Westbury; Duncan H Blair; Christopher J Armishaw; Paul F Alewood; Nia J Bryant; David E James; Jennifer L Martin
Molecular dissection of the Munc18c/syntaxin4 interaction: implications for regulation of membrane trafficking.
Traffic (Copenhagen, Denmark) 2006;7(10):1408-19.
2006: Marion L Loughnan; Annette Nicke; Alun Jones; Christina I Schroeder; Simon T Nevin; David J Adams; Paul F Alewood; Richard J Lewis
Identification of a novel class of nicotinic receptor antagonists: dimeric conotoxins VxXIIA, VxXIIB, and VxXIIC from Conus vexillum.
The Journal of biological chemistry 2006;281(34):24745-55.
2006: Julita S Imperial; Paramjit S Bansal; Paul F Alewood; Norelle L Daly; David J Craik; Annett Sporning; Heinrich Terlau; Estuardo López-Vera; Pradip K Bandyopadhyay; Baldomero M Olivera
A novel conotoxin inhibitor of Kv1.6 channel and nAChR subtypes defines a new superfamily of conotoxins.
Biochemistry 2006;45(27):8331-40.
2006: sebastien dutertre; Natalie G Lumsden; Paul F Alewood; Richard J Lewis
Isolation and characterisation of conomap-Vt, a D-amino acid containing excitatory peptide from the venom of a vermivorous cone snail.
FEBS letters 2006;580(16):3860-6.
2006: Christopher J Armishaw; Norelle L Daly; Simon T Nevin; David J Adams; David J Craik; Paul F Alewood
Alpha-selenoconotoxins, a new class of potent alpha7 neuronal nicotinic receptor antagonists.
The Journal of biological chemistry 2006;281(20):14136-43.
2006: John W Holland; Hilton C Deeth; Paul F Alewood
Resolution and characterisation of multiple isoforms of bovine kappa-casein by 2-DE following a reversible cysteine-tagging enrichment strategy.
Proteomics 2006;6(10):3087-95.
2006: David Wilson; Paul F Alewood
Taxonomy of Australian Funnel-web spiders using rp-HPLC/ESI-MS profiling techniques.
Toxicon : official journal of the International Society on Toxinology 2006;47(6):614-27.
2006: Allan M Torres; Maria Tsampazi; Chryssanthi Tsampazi; Eleanor C Kennett; Katherine Belov; Dominic P Geraghty; Paramjit S Bansal; Paul F Alewood; Philip W Kuchel
Mammalian l-to-d-amino-acid-residue isomerase from platypus venom.
FEBS letters 2006;580(6):1587-91.
2006: Paramjit S Bansal; Paul A Grieve; Ronald J Marschke; Norelle L Daly; Emily McGhie; David J Craik; Paul F Alewood
Chemical synthesis and structure elucidation of bovine kappa-casein (1-44).
Biochemical and biophysical research communications 2006;340(4):1098-103.
2006: N A Steen; Stephen Barker; Paul F Alewood
Proteins in the saliva of the Ixodida (ticks): pharmacological features and biological significance.
Toxicon : official journal of the International Society on Toxinology 2006;47(1):1-20.
2005: Suping Wen; David Wilson; Sanjaya Kuruppu; Michael L J Korsinczky; Joseph Hedrick; Ling Pang; Tim H Szeto; Wayne C Hodgson; Paul F Alewood; Graham M Nicholson
Discovery of an MIT-like atracotoxin family: spider venom peptides that share sequence homology but not pharmacological properties with AVIT family proteins.
Peptides 2005;26(12):2412-26.
2005: Allan M Torres; Chryssanthi Tsampazi; Dominic P Geraghty; Paramjit S Bansal; Paul F Alewood; Philip W Kuchel
D-amino acid residue in a defensin-like peptide from platypus venom: effect on structure and chromatographic properties.
The Biochemical journal 2005;391(Pt 2):215-20.
2005: Dianne Alewood; Kathy Nielsen; Paul F Alewood; David J Craik; Peter Andrews; Maureen Nerrie; Sara White; Teresa Domagala; Francesca Walker; Julie Rothacker; Antony W Burgess; Edouard C Nice
The role of disulfide bonds in the structure and function of murine epidermal growth factor (mEGF).
Growth factors (Chur, Switzerland) 2005;23(2):97-110.
2005: Christopher J Armishaw; Paul F Alewood
Conotoxins as research tools and drug leads.
Current protein & peptide science 2005;6(3):221-40.
2005: John W Holland; Hilton C Deeth; Paul F Alewood
Analysis of O-glycosylation site occupancy in bovine kappa-casein glycoforms separated by two-dimensional gel electrophoresis.
Proteomics 2005;5(4):990-1002.
2005: Bryan Fry; Janith C Wickramaratana; Scott Lemme; Anne Beuve; David L Garbers; Wayne C Hodgson; Paul F Alewood
Novel natriuretic peptides from the venom of the inland taipan (Oxyuranus microlepidotus): isolation, chemical and biological characterisation.
Biochemical and biophysical research communications 2005;327(4):1011-5.
2005: Eleanor C Kennett; William A Bubb; Paramjit S Bansal; Paul F Alewood; Philip W Kuchel
NMR studies of exchange between intra- and extracellular glutathione in human erythrocytes.
Redox report : communications in free radical research 2005;10(2):83-90.
2005: K Peter R Nilsson; Erica Lovelace; Christina E Caesar; Nahreen Tynngård; Paul F Alewood; Helena M Johansson; Iain A Sharpe; Richard J Lewis; Norelle L Daly; David J Craik
Solution structure of chi-conopeptide MrIA, a modulator of the human norepinephrine transporter.
Biopolymers 2005;80(6):815-23.
2005: Russell V Baudinette; Pinmanee Boontheung; Ian F Musgrave; Paul A Wabnitz; Vita M Maselli; Jayne Skinner; Paul F Alewood; Craig S Brinkworth; John H Bowie
An immunomodulator used to protect young in the pouch of the Tammar wallaby, Macropus eugenii.
The FEBS journal 2005;272(2):433-43.
2004: Janith C Wickramaratna; Bryan Fry; Richard E Loiacono; Marie-Isabel Aguilar; Paul F Alewood; Wayne C Hodgson
Isolation and characterization at cholinergic nicotinic receptors of a neurotoxin from the venom of the Acanthophis sp. Seram death adder.
Biochemical pharmacology 2004;68(2):383-94.
2004: Timothy Ravasi; Kenneth Hsu; Jesse Goyette; Kate Schroder; Zheng Yang; Ahmed Farid Rahimi; Les P Miranda; Paul F Alewood; David A Hume; Carolyn L Geczy
Probing the S100 protein family through genomic and functional analysis.
Genomics 2004;84(1):10-22.
2004: Marion L Loughnan; Paul F Alewood
Physico-chemical characterization and synthesis of neuronally active alpha-conotoxins.
European journal of biochemistry / FEBS 2004;271(12):2294-304.
2004: Gene Wijffels; Brian P Dalrymple; Pavel Prosselkov; Kritaya Kongsuwan; V Chandana Epa; Penelope E Lilley; Slobodan Jergic; Jens Buchardt; Susan E Brown; Paul F Alewood; Phillip A Jennings; Nicholas E Dixon
Inhibition of protein interactions with the beta 2 sliding clamp of Escherichia coli DNA polymerase III by peptides from beta 2-binding proteins.
Biochemistry 2004;43(19):5661-71.
2004: John W Holland; Hilton C Deeth; Paul F Alewood
Proteomic analysis of kappa-casein micro-heterogeneity.
Proteomics 2004;4(3):743-52.
2004: Marion L Loughnan; Annette Nicke; Alun Jones; David J Adams; Paul F Alewood; Richard J Lewis
Chemical and functional identification and characterization of novel sulfated alpha-conotoxins from the cone snail Conus anemone.
Journal of medicinal chemistry 2004;47(5):1234-41.
2004: David Wilson; Paul F Alewood
Australian funnel-web spider venom analyzed with on-line RP-HPLC techniques.
Methods in molecular biology (Clifton, N.J.) 2004;251():307-22.
2003: Dianne Alewood; Liesl C Birinyi-Strachan; Paul K Pallaghy; Raymond S Norton; Graham M Nicholson; Paul F Alewood
Synthesis and characterization of delta-atracotoxin-Ar1a, the lethal neurotoxin from venom of the Sydney funnel-web spider (Atrax robustus).
Biochemistry 2003;42(44):12933-40.
2003: Allan M Torres; Paramjit S Bansal; Margaret Sunde; Catherine E Clarke; Jane A Bursill; David J Smith; Asne R Bauskin; Samuel N Breit; Terence J Campbell; Paul F Alewood; Philip W Kuchel; Jamie I Vandenberg
Structure of the HERG K+ channel S5P extracellular linker: role of an amphipathic alpha-helix in C-type inactivation.
The Journal of biological chemistry 2003;278(43):42136-48.
2003: Iain A Sharpe; Elka Palant; Christina I Schroeder; David M Kaye; David J Adams; Paul F Alewood; Richard J Lewis
Inhibition of the norepinephrine transporter by the venom peptide chi-MrIA. Site of action, Na+ dependence, and structure-activity relationship.
The Journal of biological chemistry 2003;278(41):40317-23.
2003: Iain A Sharpe; Linda Thomas; Marion L Loughnan; Leonid Motin; Elka Palant; Daniel E Croker; Dianne Alewood; Songhai Chen; Robert M Graham; Paul F Alewood; David J Adams; Richard J Lewis
Allosteric alpha 1-adrenoreceptor antagonism by the conopeptide rho-TIA.
The Journal of biological chemistry 2003;278(36):34451-7.
2003: Ron C Hogg; Gene Hopping; Paul F Alewood; David J Adams; Daniel Bertrand
Alpha-conotoxins PnIA and [A10L]PnIA stabilize different states of the alpha7-L247T nicotinic acetylcholine receptor.
The Journal of biological chemistry 2003;278(29):26908-14.
2003: Allan M Torres; Paramjit S Bansal; Paul F Alewood; Jane A Bursill; Philip W Kuchel; Jamie I Vandenberg
Solution structure of CnErg1 (Ergtoxin), a HERG specific scorpion toxin.
FEBS letters 2003;539(1-3):138-42.
2003: Joanne T Blanchfield; Julie L Dutton; Ron C Hogg; Oliver P Gallagher; David J Craik; Alun Jones; David J Adams; Richard J Lewis; Paul F Alewood; Istvan Toth
Synthesis, structure elucidation, in vitro biological activity, toxicity, and Caco-2 cell permeability of lipophilic analogues of alpha-conotoxin MII.
Journal of medicinal chemistry 2003;46(7):1266-72.
2003: Wayne C Hodgson; Christer O Eriksson; Paul F Alewood; Bryan Fry
Comparison of the in vitro neuromuscular activity of venom from three Australian snakes (Hoplocephalus stephensi, Austrelaps superbus and Notechis scutatus): efficacy of tiger snake antivenom.
Clinical and experimental pharmacology & physiology 2003;30(3):127-32.
2003: Annette Nicke; Marion L Loughnan; Emma L Millard; Paul F Alewood; David J Adams; Norelle L Daly; David J Craik; Richard J Lewis
Isolation, structure, and activity of GID, a novel alpha 4/7-conotoxin with an extended N-terminal sequence.
The Journal of biological chemistry 2003;278(5):3137-44.
2002: Julie L Dutton; Paramjit S Bansal; Ron C Hogg; David J Adams; Paul F Alewood; David J Craik
A new level of conotoxin diversity, a non-native disulfide bond connectivity in alpha-conotoxin AuIB reduces structural definition but increases biological activity.
The Journal of biological chemistry 2002;277(50):48849-57.
2002: Darren R Englebretsen; Bronwyn Garnham; Paul F Alewood
A cassette ligation strategy with thioether replacement of three Gly-Gly peptide bonds: total chemical synthesis of the 101 residue protein early pregnancy factor [psi(CH(2)S)28-29,56-57,76-77].
The Journal of organic chemistry 2002;67(17):5883-90.
2002: Allan M Torres; Ian Menz; Paul F Alewood; Paramjit S Bansal; Jelle Lahnstein; Clifford H Gallagher; Philip W Kuchel
D-Amino acid residue in the C-type natriuretic peptide from the venom of the mammal, Ornithorhynchus anatinus, the Australian platypus.
FEBS letters 2002;524(1-3):172-6.
2002: Katherine J Nielsen; Michael Watson; David J Adams; Anna K M Hammarström; Peter W Gage; Justine M Hill; David J Craik; Linda Thomas; Denise Adams; Paul F Alewood; Richard J Lewis
Solution structure of mu-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channels.
The Journal of biological chemistry 2002;277(30):27247-55.
2002: Allan M Torres; Dianne Alewood; Paul F Alewood; Clifford H Gallagher; Philip W Kuchel
Conformations of platypus venom C-type natriuretic peptide in aqueous solution and sodium dodecyl sulfate micelles.
Toxicon : official journal of the International Society on Toxinology 2002;40(6):711-9.
2002: Johan Rosengren; David Wilson; Norelle L Daly; Paul F Alewood; David J Craik
Solution structures of the cis- and trans-Pro30 isomers of a novel 38-residue toxin from the venom of Hadronyche Infensa sp. that contains a cystine-knot motif within its four disulfide bonds.
Biochemistry 2002;41(10):3294-301.
2002: Isobel D Lawrenson; Sabine H Wimmer-Kleikamp; Peter Lock; Simone M Schoenwaelder; Michelle Down; Andrew W Boyd; Paul F Alewood; Martin Lackmann
Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling.
Journal of cell science 2002;115(Pt 5):1059-72.
2002: Andis Graudins; David Wilson; Paul F Alewood; Kevin W Broady; Graham M Nicholson
Cross-reactivity of Sydney funnel-web spider antivenom: neutralization of the in vitro toxicity of other Australian funnel-web (Atrax and Hadronyche) spider venoms.
Toxicon : official journal of the International Society on Toxinology 2002;40(3):259-66.
2002: Bryan Fry; Janith C Wickramaratna; Wayne C Hodgson; Paul F Alewood; R Manjunatha Kini; Hao Ho; Wolfgang Wüster
Electrospray liquid chromatography/mass spectrometry fingerprinting of Acanthophis (death adder) venoms: taxonomic and toxinological implications.
Rapid communications in mass spectrometry : RCM 2002;16(6):600-8.
2002: Pinmanee Boontheung; Paul F Alewood; Craig S Brinkworth; John H Bowie; Paul A Wabnitz; Michael J Tyler
Negative ion electrospray mass spectra of caerulein peptides: an aid to structural determination.
Rapid communications in mass spectrometry : RCM 2002;16(4):281-6.
2001: Gregory T Bourne; S W Golding; Ross P McGeary; Wim D F Meutermans; A Jones; Garland R Marshall; Paul F Alewood; Mark L Smythe
The development and application of a novel safety-catch linker for BOC-based assembly of libraries of cyclic peptides.
The Journal of organic chemistry 2001;66(23):7706-13.
2001: Bryan Fry; Janith C Wickramaratna; A Jones; Paul F Alewood; Wayne C Hodgson
Species and regional variations in the effectiveness of antivenom against the in vitro neurotoxicity of death adder (Acanthophis) venoms.
Toxicology and applied pharmacology 2001;175(2):140-8.
2001: Iain A Sharpe; J Gehrmann; Marion L Loughnan; Linda Thomas; Denise A Adams; AR Atkins; Elka Palant; David J Craik; David J Adams; Paul F Alewood; Richard J Lewis
Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporter.
Nature neuroscience 2001;4(9):902-7.
2001: Jackie A Wilce; Stephen G Love; S J Richardson; Paul F Alewood; David J Craik
Synthesis of an analog of the thyroid hormone-binding protein transthyretin via regioselective chemical ligation.
The Journal of biological chemistry 2001;276(28):25997-6003.
2001: Les P Miranda; T Tao; A Jones; IV Chernushevich; K G Standing; Carolyn L Geczy; Paul F Alewood
Total chemical synthesis and chemotactic activity of human S100A12 (EN-RAGE).
FEBS letters 2001;488(1-2):85-90.
2000: Bing Zhang; Jacqueline Harness; Maria J Somodevilla-Torres; Narelle C Hillyard; A W Mould; Dianne Alewood; Stephen G Love; Paul F Alewood; Judith Greer; Alice C Cavanagh; Pamela McCombe; Halle Morton
Early pregnancy factor suppresses experimental autoimmune encephalomyelitis induced in Lewis rats with myelin basic protein and in SJL/J mice with myelin proteolipid protein peptide 139-151.
Journal of the neurological sciences 2000;182(1):5-15.
2000: Richard J Lewis; Katherine J Nielsen; David J Craik; Marion L Loughnan; Denise A Adams; Iain A Sharpe; Tudor Luchian; David J Adams; T Bond; Linda Thomas; Alun Jones; J L Matheson; Roger Drinkwater; P R Andrews; Paul F Alewood
Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes.
The Journal of biological chemistry 2000;275(45):35335-44.
2000: Joel D A Tyndall; Robert C Reid; David P Tyssen; D K Jardine; B Todd; M Passmore; Darren R March; Leonard K Pattenden; DA Bergman; Dianne Alewood; S H Hu; Paul F Alewood; Chris Birch; Jennifer L Martin; David P Fairlie
Synthesis, stability, antiviral activity, and protease-bound structures of substrate-mimicking constrained macrocyclic inhibitors of HIV-1 protease.
Journal of medicinal chemistry 2000;43(19):3495-504.
2000: Les P Miranda; Wim D F Meutermans; Mark L Smythe; Paul F Alewood
An activated O --> N acyl transfer auxiliary: efficient amide-backbone substitution of hindered "difficult" peptides.
The Journal of organic chemistry 2000;65(18):5460-8.
2000: Justine M Hill; Paul F Alewood; David J Craik
Conotoxin TVIIA, a novel peptide from the venom of Conus tulipa 2. Three-dimensional solution structure.
European journal of biochemistry / FEBS 2000;267(15):4649-57.
2000: Justine M Hill; AR Atkins; Marion L Loughnan; Alun Jones; Denise A Adams; R C Martin; Richard J Lewis; David J Craik; Paul F Alewood
Conotoxin TVIIA, a novel peptide from the venom of Conus tulipa 1. Isolation, characterization and chemical synthesis.
European journal of biochemistry / FEBS 2000;267(15):4642-8.
2000: Natalie M Broxton; L Miranda; J Gehrmann; John Down; Paul F Alewood; Bruce G Livett
Leu(10) of alpha-conotoxin PnIB confers potency for neuronal nicotinic responses in bovine chromaffin cells.
European journal of pharmacology 2000;390(3):229-36.
2000: Les P Miranda; Paul F Alewood
Challenges for protein chemical synthesis in the 21st century: bridging genomics and proteomics.
Biopolymers 2000;55(3):217-26.
2000: Maria J Somodevilla-Torres; Narelle C Hillyard; Halle Morton; Dianne Alewood; Judy A Halliday; Paul F Alewood; David A Vesey; Michael D Walsh; Alice C Cavanagh
Preparation and characterization of polyclonal antibodies against human chaperonin 10.
Cell stress & chaperones 2000;5(1):14-20.
1999: Ron C Hogg; Les P Miranda; David J Craik; Richard J Lewis; Paul F Alewood; David J Adams
Single amino acid substitutions in alpha-conotoxin PnIA shift selectivity for subtypes of the mammalian neuronal nicotinic acetylcholine receptor.
The Journal of biological chemistry 1999;274(51):36559-64.
1999: Norelle L Daly; S Love; Paul F Alewood; David J Craik
Chemical synthesis and folding pathways of large cyclic polypeptides: studies of the cystine knot polypeptide kalata B1.
Biochemistry 1999;38(32):10606-14.
1999: Allan M Torres; X Wang; JI Fletcher; Dianne Alewood; Paul F Alewood; R Smith; R J Simpson; Graham M Nicholson; S K Sutherland; Clifford H Gallagher; Glenn F King; Philip W Kuchel
Solution structure of a defensin-like peptide from platypus venom.
The Biochemical journal 1999;341 ( Pt 3)():785-94.
1999: J Gehrmann; Norelle L Daly; Paul F Alewood; David J Craik
Solution structure of alpha-conotoxin ImI by 1H nuclear magnetic resonance.
Journal of medicinal chemistry 1999;42(13):2364-72.
1999: Katherine J Nielsen; D Adams; Linda Thomas; T Bond; Paul F Alewood; David J Craik; Richard J Lewis
Structure-activity relationships of omega-conotoxins MVIIA, MVIIC and 14 loop splice hybrids at N and P/Q-type calcium channels.
Journal of molecular biology 1999;289(5):1405-21.
1999: Jennifer L Martin; Jake Begun; A Schindeler; Wasantha A Wickramasinghe; Dianne Alewood; Paul F Alewood; DA Bergman; Ross I Brinkworth; Giovanni Abbenante; Darren R March; Robert C Reid; David P Fairlie
Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease.
Biochemistry 1999;38(25):7978-88.
1999: Katherine J Nielsen; Denise A Adams; Paul F Alewood; Richard J Lewis; Linda Thomas; T Schroeder; David J Craik
Effects of chirality at Tyr13 on the structure-activity relationships of omega-conotoxins from Conus magus.
Biochemistry 1999;38(21):6741-51.
1999: Natalie M Broxton; John Down; J Gehrmann; Paul F Alewood; DG Satchell; Bruce G Livett
Alpha-conotoxin ImI inhibits the alpha-bungarotoxin-resistant nicotinic response in bovine adrenal chromaffin cells.
Journal of neurochemistry 1999;72(4):1656-62.
1999: CA Harrison; Mark J Raftery; J Walsh; Paul F Alewood; Siiri Iismaa; S Thliveris; Carolyn L Geczy
Oxidation regulates the inflammatory properties of the murine S100 protein S100A8.
The Journal of biological chemistry 1999;274(13):8561-9.
1999: Les P Miranda; Paul F Alewood
Accelerated chemical synthesis of peptides and small proteins.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(4):1181-6.
1999: Katherine J Nielsen; N Skjaerbaek; M Dooley; Denise A Adams; Martin Mortensen; Peter R Dodd; David J Craik; Paul F Alewood; Richard J Lewis
Structure-activity studies of conantokins as human N-methyl-D-aspartate receptor modulators.
Journal of medicinal chemistry 1999;42(3):415-26.
1998: Justine M Hill; C J Oomen; Les P Miranda; J P Bingham; Paul F Alewood; David J Craik
Three-dimensional solution structure of alpha-conotoxin MII by NMR spectroscopy: effects of solution environment on helicity.
Biochemistry 1998;37(45):15621-30.
1998: S H Hu; Marion L Loughnan; R Miller; C M Weeks; Robert H Blessing; Paul F Alewood; Richard J Lewis; Jennifer L Martin
The 1.1 A resolution crystal structure of [Tyr15]EpI, a novel alpha-conotoxin from Conus episcopatus, solved by direct methods.
Biochemistry 1998;37(33):11425-33.
1998: Kevin J Barnham; A M Torres; Dianne Alewood; Paul F Alewood; Teresa Domagala; Edouard Nice; Raymond S Norton
Role of the 6-20 disulfide bridge in the structure and activity of epidermal growth factor.
Protein science : a publication of the Protein Society 1998;7(8):1738-49.
1998: Marion L Loughnan; T Bond; AR Atkins; J Cuevas; David J Adams; Natalie M Broxton; Bruce G Livett; John Down; Alun Jones; Paul F Alewood; Richard J Lewis
alpha-conotoxin EpI, a novel sulfated peptide from Conus episcopatus that selectively targets neuronal nicotinic acetylcholine receptors.
The Journal of biological chemistry 1998;273(25):15667-74.
1998: J Gehrmann; Paul F Alewood; David J Craik
Structure determination of the three disulfide bond isomers of alpha-conotoxin GI: a model for the role of disulfide bonds in structural stability.
Journal of molecular biology 1998;278(2):401-15.
1998: Martin Lackmann; A G Harpur; Andrew Oates; R J Mann; A Gabriel; Wim D F Meutermans; Paul F Alewood; I M Kerr; G R Stark; Andrew Wilks
Biomolecular interaction analysis of IFN gamma-induced signaling events in whole-cell lysates: prevalence of latent STAT1 in high-molecular weight complexes.
Growth factors (Chur, Switzerland) 1998;16(1):39-51.
1997: Martin Scanlon; D Naranjo; Linda Thomas; Paul F Alewood; Richard J Lewis; David J Craik
Solution structure and proposed binding mechanism of a novel potassium channel toxin kappa-conotoxin PVIIA.
Structure (London, England : 1993) 1997;5(12):1585-97.
1997: Paul K Pallaghy; Dianne Alewood; Paul F Alewood; Raymond S Norton
Solution structure of robustoxin, the lethal neurotoxin from the funnel-web spider Atrax robustus.
FEBS letters 1997;419(2-3):191-6.
1997: S H Hu; J Gehrmann; Paul F Alewood; David J Craik; Jennifer L Martin
Crystal structure at 1.1 A resolution of alpha-conotoxin PnIB: comparison with alpha-conotoxins PnIA and GI.
Biochemistry 1997;36(38):11323-30.
1997: Justine M Hill; Paul F Alewood; David J Craik
Solution structure of the sodium channel antagonist conotoxin GS: a new molecular caliper for probing sodium channel geometry.
Structure (London, England : 1993) 1997;5(4):571-83.
1997: N Skjaerbaek; Katherine J Nielsen; Richard J Lewis; Paul F Alewood; David J Craik
Determination of the solution structures of conantokin-G and conantokin-T by CD and NMR spectroscopy.
The Journal of biological chemistry 1997;272(4):2291-9.
1997: Paul F Alewood; Dianne Alewood; L Miranda; S Love; Wim D F Meutermans; David Wilson
Rapid in situ neutralization protocols for Boc and Fmoc solid-phase chemistries.
Methods in enzymology 1997;289():14-29.
1996: Katherine J Nielsen; Linda Thomas; Richard J Lewis; Paul F Alewood; David J Craik
A consensus structure for omega-conotoxins with different selectivities for voltage-sensitive calcium channel subtypes: comparison of MVIIA, SVIB and SNX-202.
Journal of molecular biology 1996;263(2):297-310.
1996: G R Donovan; M D Street; T Tetaz; A I Smith; Dianne Alewood; Paul F Alewood; S K Sutherland; B A Baldo
Expression of jumper ant (Myrmecia pilosula) venom allergens: post-translational processing of allergen gene products.
Biochemistry and molecular biology international 1996;39(5):877-85.
1996: Justine M Hill; Paul F Alewood; David J Craik
Three-dimensional solution structure of mu-conotoxin GIIIB, a specific blocker of skeletal muscle sodium channels.
Biochemistry 1996;35(27):8824-35.
1996: S H Hu; J Gehrmann; Luke W Guddat; Paul F Alewood; David J Craik; Jennifer L Martin
The 1.1 A crystal structure of the neuronal acetylcholine receptor antagonist, alpha-conotoxin PnIA from Conus pennaceus.
Structure (London, England : 1993) 1996;4(4):417-23.
1996: A Jones; J P Bingham; J Gehrmann; T Bond; Marion L Loughnan; AR Atkins; Richard J Lewis; Paul F Alewood
Isolation and characterization of conopeptides by high-performance liquid chromatography combined with mass spectrometry and tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM 1996;10(1):138-43.
1994: Ian Nicholls; David J Craik; Paul F Alewood
NMR and molecular modelling based conformational analysis of some N-alkyl 1- and 2-benzazepinones: useful central nervous system agent design motifs.
Biochemical and biophysical research communications 1994;205(1):98-104.
1994: Richard J Lewis; J P Bingham; A Jones; Paul F Alewood; P R Andrews
Drugs from the peptide venoms of marine cone shells.
Australasian biotechnology 1994;4(5):298-300.
1994: G R Donovan; M D Street; B A Baldo; Dianne Alewood; Paul F Alewood; S Sutherland
Identification of an IgE-binding determinant of the major allergen Myr p I from the venom of the Australian jumper ant Myrmecia pilosula.
Biochimica et biophysica acta 1994;1204(1):48-52.
1993: K Nash; M Feldmuller; John de Jersey; Paul F Alewood; S Hamilton
Continuous and discontinuous assays for phosphotyrosyl protein phosphatase activity using phosphotyrosyl peptide substrates.
Analytical biochemistry 1993;213(2):303-9.
1993: Paul F Alewood; A J Bailey; Ross I Brinkworth; David P Fairlie; A Jones
Characterisation of TNF-alpha-related peptides by high-performance liquid chromatography-mass spectrometry and high-performance liquid chromatography-tandem mass spectrometry.
Journal of chromatography 1993;646(1):185-91.
1993: M Baca; Paul F Alewood; SB Kent
Structural engineering of the HIV-1 protease molecule with a beta-turn mimic of fixed geometry.
Protein science : a publication of the Protein Society 1993;2(7):1085-91.
1993: Ian Nicholls; S F Morrison; Ross I Brinkworth; Paul F Alewood; P R Andrews
Central nervous system receptor binding profiles of some 2-amino-4-phenyl quinolines: a novel class of alpha 2-adrenoceptor selective ligands.
Life sciences 1993;53(20):PL343-7.
1992: M Schnölzer; Paul F Alewood; A Jones; Dianne Alewood; S B Kent
In situ neutralization in Boc-chemistry solid phase peptide synthesis. Rapid, high yield assembly of difficult sequences.
International journal of peptide and protein research 1992;40(3-4):180-93.
1992: M Schnölzer; A Jones; Paul F Alewood; SB Kent
Ion-spray tandem mass spectrometry in peptide synthesis: structural characterization of minor by-products in the synthesis of ACP(65-74).
Analytical biochemistry 1992;204(2):335-43.
1990: J B Ball; P R Andrews; Paul F Alewood; R A Hughes
A one-variable topographical descriptor for the beta-turns of peptides and proteins.
FEBS letters 1990;273(1-2):15-8.
1990: J B Ball; Paul F Alewood
Conformational constraints: nonpeptide beta-turn mimics.
Journal of molecular recognition : JMR 1990;3(2):55-64.