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Jean Chmielewski

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TOP 3
Jerrin Kuriakose; Christine A Hrycyna; Jean Chmielewski
Click chemistry-derived bivalent quinine inhibitors of P-glycoprotein-mediated cellular efflux.
Jean Chmielewski; Christine Hrycyna
Tools for eradicating HIV in the brain: prodrug dimeric inhibitors of P-gp.
Charles Rubert Pérez; Daneli López-Pérez; Jean Chmielewski; Mark Lipton
Small molecule inhibitors of anthrax toxin-induced cytotoxicity targeted against protective antigen.

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All Publications

2012: Jerrin Kuriakose; Christine A Hrycyna; Jean Chmielewski
Click chemistry-derived bivalent quinine inhibitors of P-glycoprotein-mediated cellular efflux.
Bioorganic & medicinal chemistry letters 2012;22(13):4410-2.
2012: Jean Chmielewski; Christine Hrycyna
Tools for eradicating HIV in the brain: prodrug dimeric inhibitors of P-gp.
Therapeutic delivery 2012;3(6):689-92.
2012: Charles Rubert Pérez; Daneli López-Pérez; Jean Chmielewski; Mark Lipton
Small molecule inhibitors of anthrax toxin-induced cytotoxicity targeted against protective antigen.
Chemical biology & drug design 2012;79(3):260-9.
2011: Iris M Geisler; Jean Chmielewski
Dimeric cationic amphiphilic polyproline helices for mitochondrial targeting.
Pharmaceutical research 2011;28(11):2797-807.
2011: Charles M Rubert Pérez; Alyssa Panitch; Jean Chmielewski
A collagen peptide-based physical hydrogel for cell encapsulation.
Macromolecular bioscience 2011;11(10):1426-31.
2011: Marcos M Pires; David E Przybyla; Charles M Rubert Pérez; Jean Chmielewski
Metal-mediated tandem coassembly of collagen peptides into banded microstructures.
Journal of the American Chemical Society 2011;133(37):14469-71.
2010: Song-Gil Lee; Jean Chmielewski
Cross-linked peptoid-based dimerization inhibitors of HIV-1 protease.
Chembiochem : a European journal of chemical biology 2010;11(11):1513-6.
2010: David E Przybyla; Jean Chmielewski
Metal-triggered collagen peptide disk formation.
Journal of the American Chemical Society 2010;132(23):7866-7.
2010: David E Przybyla; Jean Chmielewski
Higher-order assembly of collagen peptides into nano- and microscale materials.
Biochemistry 2010;49(21):4411-9.
2010: Li Li; Iris Geisler; Jean Chmielewski; Ji-Xin Cheng
Cationic amphiphilic polyproline helix P11LRR targets intracellular mitochondria.
Journal of controlled release : official journal of the Controlled Release Society 2010;142(2):259-66.
2010: Jeeyeon Lee; Jean Chmielewski
Folding studies of pH-dependent collagen peptides.
Chemical biology & drug design 2010;75(2):161-8.
2009: Hilda Namanja; Dana Emmert; Marcos M Pires; Christine A Hrycyna; Jean Chmielewski
Inhibition of human P-glycoprotein transport and substrate binding using a galantamine dimer.
Biochemical and biophysical research communications 2009;388(4):672-6.
2009: Jean Chmielewski
Protease dimer formation disrupted.
Nature chemical biology 2009;5(9):607-8.
2009: Marcos M Pires; Jean Chmielewski
Self-assembly of collagen peptides into microflorettes via metal coordination.
Journal of the American Chemical Society 2009;131(7):2706-12.
2009: Michael J Bowman; Jean Chmielewski
Sidechain-linked inhibitors of HIV-1 protease dimerization.
Bioorganic & medicinal chemistry 2009;17(3):967-76.
2009: Marcos M Pires; David E Przybyla; Jean Chmielewski
A metal-collagen peptide framework for three-dimensional cell culture.
Angewandte Chemie (International ed. in English) 2009;48(42):7813-7.
2009: Iris Geisler; Jean Chmielewski
Cationic amphiphilic polyproline helices: side-chain variations and cell-specific internalization.
Chemical biology & drug design 2009;73(1):39-45.
2008: Brandon D Gaddis; Charles M Rubert Pérez; Jean Chmielewski
Inhibitors of anthrax lethal factor based upon N-oleoyldopamine.
Bioorganic & medicinal chemistry letters 2008;18(7):2467-70.
2008: Marcos M Pires; Jean Chmielewski
Fluorescence imaging of cellular glutathione using a latent rhodamine.
Organic letters 2008;10(5):837-40.
2008: Song-Gil Lee; Jee Yeon Lee; Jean Chmielewski
Investigation of pH-dependent collagen triple-helix formation.
Angewandte Chemie (International ed. in English) 2008;47(44):8429-32.
2007: Brandon D Gaddis; Larisa V Avramova; Jean Chmielewski
Inhibitors of anthrax lethal factor.
Bioorganic & medicinal chemistry letters 2007;17(16):4575-8.
2007: Yannick Fillon; Ayush Verma; Partha Ghosh; Dawn Ernenwein; Vincent M Rotello; Jean Chmielewski
Peptide ligation catalyzed by functionalized gold nanoparticles.
Journal of the American Chemical Society 2007;129(21):6676-7.
2007: Iris Geisler; Jean Chmielewski
Probing length effects and mechanism of cell penetrating agents mounted on a polyproline helix scaffold.
Bioorganic & medicinal chemistry letters 2007;17(10):2765-8.
2007: Stefan J Hershberger; Song-Gil Lee; Jean Chmielewski
Scaffolds for blocking protein-protein interactions.
Current topics in medicinal chemistry 2007;7(10):928-42.
2006: Marcos M Pires; Christine A Hrycyna; Jean Chmielewski
Bivalent probes of the human multidrug transporter P-glycoprotein.
Biochemistry 2006;45(38):11695-702.
2006: Song-Gil Lee; Jean Chmielewski
Rapid synthesis and in situ screening of potent HIV-1 protease dimerization inhibitors.
Chemistry & biology 2006;13(4):421-6.
2006: Luckner G Ulysse; Jean Chmielewski
A light-activated beta-turn scaffold within a somatostatin analog: NMR structure and biological activity.
Chemical biology & drug design 2006;67(2):127-36.
2005: Yannick A Fillon; Jason P Anderson; Jean Chmielewski
Cell penetrating agents based on a polyproline helix scaffold.
Journal of the American Chemical Society 2005;127(33):11798-803.
2005: Michael J Bowman; Simon Byrne; Jean Chmielewski
Switching between allosteric and dimerization inhibition of HIV-1 protease.
Chemistry & biology 2005;12(4):439-44.
2005: You Seok Hwang; Jean Chmielewski
Development of low molecular weight HIV-1 protease dimerization inhibitors.
Journal of medicinal chemistry 2005;48(6):2239-42.
2005: H-M Lee; Jean Chmielewski
Liposomal cargo unloading induced by pH-sensitive peptides.
The journal of peptide research : official journal of the American Peptide Society 2005;65(3):355-63.
2005: Lei Zhao; Jean Chmielewski
Inhibiting protein-protein interactions using designed molecules.
Current opinion in structural biology 2005;15(1):31-4.
2004: Indraneel Ghosh; Jean Chmielewski
Peptide self-assembly as a model of proteins in the pre-genomic world.
Current opinion in chemical biology 2004;8(6):640-4.
2004: Michael D Shultz; Young-Wan Ham; Song-Gil Lee; David A Davis; Cara Brown; Jean Chmielewski
Small-molecule dimerization inhibitors of wild-type and mutant HIV protease: a focused library approach.
Journal of the American Chemical Society 2004;126(32):9886-7.
2004: You Seok Hwang; Jean Chmielewski
A unidirectional crosslinking strategy for HIV-1 protease dimerization inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(16):4297-300.
2004: Michael J Bowman; Jean Chmielewski
Crucial amides for dimerization inhibitors of HIV-1 protease.
Bioorganic & medicinal chemistry letters 2004;14(6):1395-8.
2004: A D Ragin; Jean Chmielewski
Probing essential residues for cellular uptake with a cationic nuclear localization signal sequence.
The journal of peptide research : official journal of the American Peptide Society 2004;63(2):155-60.
2003: Xiangqun Li; Jean Chmielewski
Peptide self-replication enhanced by a proline kink.
Journal of the American Chemical Society 2003;125(39):11820-1.
2003: Lei Zhao; Mary O'Reilly; Michael D Shultz; Jean Chmielewski
Interfacial peptide inhibitors of HIV-1 integrase activity and dimerization.
Bioorganic & medicinal chemistry letters 2003;13(6):1175-7.
2003: Xiangqun Li; Jean Chmielewski
Challenges in the design of self replicating peptides.
Organic & biomolecular chemistry 2003;1(6):901-4.
2002: Angela D Ragin; Rashida A Morgan; Jean Chmielewski
Cellular import mediated by nuclear localization signal Peptide sequences.
Chemistry & biology 2002;9(8):943-8.
2002: Roy Issac; Jean Chmielewski
Approaching exponential growth with a self-replicating peptide.
Journal of the American Chemical Society 2002;124(24):6808-9.
2002: Mary Jo Turk; Joseph A Reddy; Jean Chmielewski; Philip S Low
Characterization of a novel pH-sensitive peptide that enhances drug release from folate-targeted liposomes at endosomal pHs.
Biochimica et biophysica acta 2002;1559(1):56-68.
2002: Michael J Bowman; Jean Chmielewski
Novel strategies for targeting the dimerization interface of HIV protease with cross-linked interfacial peptides.
Biopolymers 2002;66(2):126-33.
2001: H C Wang; M Kurimoto; B Kahr; Jean Chmielewski
Alpha-lactose monohydrate single crystals as hosts for matrix isolation of guest biopolymers.
Bioorganic & medicinal chemistry 2001;9(9):2279-83.
2001: Roy Issac; Y W Ham; Jean Chmielewski
The design of self-replicating helical peptides.
Current opinion in structural biology 2001;11(4):458-63.
2001: Indraneel Ghosh; P Bishop; Jean Chmielewski
DNA binding properties of basic helix-loop-helix fusion proteins of Tal and E47.
The journal of peptide research : official journal of the American Peptide Society 2001;57(5):354-60.
2000: R Zutshi; Jean Chmielewski
Targeting the dimerization interface for irreversible inhibition of HIV-1 protease.
Bioorganic & medicinal chemistry letters 2000;10(17):1901-3.
1999: C Micklatcher; Jean Chmielewski
Helical peptide and protein design.
Current opinion in chemical biology 1999;3(6):724-9.
1999: Michael D Shultz; Jean Chmielewski
Probing the role of interfacial residues in a dimerization inhibitor of HIV-1 protease.
Bioorganic & medicinal chemistry letters 1999;9(16):2431-6.
1999: S Yao; Jean Chmielewski
A pH-tunable peptide ligase.
Biopolymers 1999;51(5):370-5.
1999: Indraneel Ghosh; Roy Issac; Jean Chmielewski
Structure-function relationship in a beta-sheet peptide inhibitor of E47 dimerization and DNA binding.
Bioorganic & medicinal chemistry 1999;7(1):61-6.
1998: S Yao; Indraneel Ghosh; R Zutshi; Jean Chmielewski
Selective amplification by auto- and cross-catalysis in a replicating peptide system.
Nature 1998;396(6710):447-50.
1998: L G Ulysse; Jean Chmielewski
Restricting the flexibility of crosslinked, interfacial peptide inhibitors of HIV-1 protease.
Bioorganic & medicinal chemistry letters 1998;8(22):3281-6.
1998: Indraneel Ghosh; Jean Chmielewski
A beta-sheet peptide inhibitor of E47 dimerization and DNA binding.
Chemistry & biology 1998;5(8):439-45.
1998: M Brickner; Jean Chmielewski
Inhibiting the dimeric restriction endonuclease EcoRI using interfacial helical peptides.
Chemistry & biology 1998;5(6):339-43.
1998: S Yao; R Zutshi; Jean Chmielewski
Endothiopeptide inhibitors of HIV-1 protease.
Bioorganic & medicinal chemistry letters 1998;8(6):699-704.
1998: R Zutshi; M Brickner; Jean Chmielewski
Inhibiting the assembly of protein-protein interfaces.
Current opinion in chemical biology 1998;2(1):62-6.
1998: S Yao; M Brickner; Elsie I Pares-Matos; Jean Chmielewski
Uncoiling c-Jun coiled coils: inhibitory effects of truncated Fos peptides on Jun dimerization and DNA binding in vitro.
Biopolymers 1998;47(4):277-83.
1996: K Vogel; J Cook; Jean Chmielewski
Subtilisin-catalyzed religation of proteolyzed hen egg-white lysozyme: investigation of the role of disulfides.
Chemistry & biology 1996;3(4):295-9.
1995: P Bishop; C Jones; Indraneel Ghosh; Jean Chmielewski
Synthesis of the basic-helix-loop-helix region of the immunoglobulin enhancer binding protein E47 and evaluation of its structural and DNA binding properties.
International journal of peptide and protein research 1995;46(2):149-54.
1994: Jean Chmielewski; M Lipton
The rational design of highly stable, amphiphilic helical peptides.
International journal of peptide and protein research 1994;44(2):152-7.