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Yoon Cho-Chung

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Chemicals & Drugs

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Chris Cheadle; Maria Nesterova; Tonya Watkins; Kathleen C Barnes; John C Hall; Antony Rosen; Kevin G Becker; Yoon S Cho-Chung
Regulatory subunits of PKA define an axis of cellular proliferation/differentiation in ovarian cancer cells.
Chris Cheadle; Kevin G Becker; Yoon S Cho-Chung; Maria V Nesterova; Tonya Watkins; William Wood; Vinayakumar Prabhu; Kathleen C Barnes
A rapid method for microarray cross platform comparisons using gene expression signatures.
Maria V Nesterova; Natalie Johnson; Chris Cheadle; Susan E Bates; Sridhar Mani; Constantine Straturis; Islam U Khan; Islam Kahn; Rishab K Gupta; Yoon S Cho-Chung
Autoantibody cancer biomarker: extracellular protein kinase A.

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2008: Chris Cheadle; Maria Nesterova; Tonya Watkins; Kathleen C Barnes; John C Hall; Antony Rosen; Kevin G Becker; Yoon S Cho-Chung
Regulatory subunits of PKA define an axis of cellular proliferation/differentiation in ovarian cancer cells.
BMC medical genomics 2008;1():43.
2007: Chris Cheadle; Kevin G Becker; Yoon S Cho-Chung; Maria V Nesterova; Tonya Watkins; William Wood; Vinayakumar Prabhu; Kathleen C Barnes
A rapid method for microarray cross platform comparisons using gene expression signatures.
Molecular and cellular probes 2007;21(1):35-46.
2006: Maria V Nesterova; Natalie Johnson; Chris Cheadle; Susan E Bates; Sridhar Mani; Constantine Straturis; Islam U Khan; Islam Kahn; Rishab K Gupta; Yoon S Cho-Chung
Autoantibody cancer biomarker: extracellular protein kinase A.
Cancer research 2006;66(18):8971-4.
2006: Yoon S Cho-Chung
Autoantibody biomarkers in the detection of cancer.
Biochimica et biophysica acta 2006;1762(6):587-91.
2006: Maria V Nesterova; N Johnson; Chris Cheadle; Yoon S Cho-Chung
Autoantibody biomarker opens a new gateway for cancer diagnosis.
Biochimica et biophysica acta 2006;1762(4):398-403.
2006: Jae-Eun Pie; Jin-Hee Park; Yoon-Hee Park; Yeon-Mi Ryu; Ki-Nam Kim; Seung-Woo Suh; Kevin G Becker; Yoon S Cho-Chung; Meyoung-Kon Kim
Effect of genistein on the expression of bone metabolism genes in ovariectomized mice using a cDNA microarray.
The Journal of nutritional biochemistry 2006;17(3):157-64.
2005: Maria V Nesterova; Yoon S Cho-Chung
Chemoprevention with protein kinase A RIalpha antisense in DMBA-mammary carcinogenesis.
Annals of the New York Academy of Sciences 2005;1058():255-64.
2005: Chris Cheadle; JINSHUI FAN; Yoon S Cho-Chung; Thomas Werner; Jill Ray; Lana Do; Myriam Gorospe; Kevin G Becker
Stability regulation of mRNA and the control of gene expression.
Annals of the New York Academy of Sciences 2005;1058():196-204.
2005: Yoon S Cho-Chung; Maria V Nesterova
Tumor reversion: protein kinase A isozyme switching.
Annals of the New York Academy of Sciences 2005;1058():76-86.
2005: Maria V Nesterova; Natalie R Johnson; Trina Stewart; Scott Abrams; Yoon S Cho-Chung
CpG immunomer DNA enhances antisense protein kinase A RIalpha inhibition of multidrug-resistant colon carcinoma growth in nude mice: molecular basis for combinatorial therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(16):5950-5.
2005: Chris Cheadle; JINSHUI FAN; Yoon S Cho-Chung; Thomas Werner; Jill Ray; Lana Do; Myriam Gorospe; Kevin G Becker
Control of gene expression during T cell activation: alternate regulation of mRNA transcription and mRNA stability.
BMC genomics 2005;6():75.
2004: Kurt J Griffin; Lawrence S Kirschner; Ludmila Matyakhina; Sotirios Stergiopoulos; Audrey Robinson-White; Sara M Lenherr; Frank D Weinberg; Edward Claflin; Elise Meoli; Yoon S Cho-Chung; Constantine Straturis
Down-regulation of regulatory subunit type 1A of protein kinase A leads to endocrine and other tumors.
Cancer research 2004;64(24):8811-5.
2004: Kurt J Griffin; Lawrence S Kirschner; Ludmila Matyakhina; Sotirios Stergiopoulos; Audrey Robinson-White; Sara M Lenherr; Frank D Weinberg; E S Claflin; Dalia L Batista; Isabelle Bourdeau; Antonis Voutetakis; Fabiano Sandrini; Elise Meoli; A J Bauer; Yoon S Cho-Chung; Stefan R Bornstein; J Aidan Carney; Constantine Straturis
A transgenic mouse bearing an antisense construct of regulatory subunit type 1A of protein kinase A develops endocrine and other tumours: comparison with Carney complex and other PRKAR1A induced lesions.
Journal of medical genetics 2004;41(12):923-31.
2004: Catherine Neary; Maria V Nesterova; Yee Sook Cho; Chris Cheadle; Kevin G Becker; Yoon S Cho-Chung
Protein kinase A isozyme switching: eliciting differential cAMP signaling and tumor reversion.
Oncogene 2004;23(54):8847-56.
2004: Maria V Nesterova; Yoon S Cho-Chung
Killing the messenger: antisense DNA and siRNA.
Current drug targets 2004;5(8):683-9.
2004: Maria V Nesterova; Yoon S Cho-Chung
Antisense protein kinase A RIalpha inhibits 7,12-dimethylbenz(a)anthracene-induction of mammary cancer: blockade at the initial phase of carcinogenesis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(13):4568-77.
2004: Yoon S Cho-Chung
Antisense protein kinase A RI alpha-induced tumor reversion: portrait of a microarray.
Biochimica et biophysica acta 2004;1697(1-2):71-9.
2003: Sridhar Mani; SANJAY GOEL; Maria V Nesterova; R M Martin; J M Grindel; M L Rothenberg; R Zhang; G Tortora; Yoon S Cho-Chung
Clinical studies in patients with solid tumors using a second-generation antisense oligonucleotide (GEM 231) targeted against protein kinase A type I.
Annals of the New York Academy of Sciences 2003;1002():252-62.
2003: Yoon S Cho-Chung
CRE-enhancer DNA decoy: a tumor target-based genetic tool.
Annals of the New York Academy of Sciences 2003;1002():124-33.
2003: Young Hoon Kim; Do-Sun Lim; Ji Hye Lee; Do-Sun Lim; Wan Joo Shim; Young Moo Ro; Gil-Hong Park; Kevin G Becker; Yoon S Cho-Chung; Meyoung-Kon Kim
Gene expression profiling of oxidative stress on atrial fibrillation in humans.
Experimental & molecular medicine 2003;35(5):336-49.
2003: Yoon S Cho-Chung; Kevin G Becker
A genome-wide view of antisense.
Nature biotechnology 2003;21(5):492.
2003: Yoon S Cho-Chung
Antisense DNAs as targeted genetic medicine to treat cancer.
Archives of pharmacal research 2003;26(3):183-91.
2003: Yee Sook Cho; Yoon S Cho-Chung
Antisense protein kinase A RIalpha acts synergistically with hydroxycamptothecin to inhibit growth and induce apoptosis in human cancer cells: molecular basis for combinatorial therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(3):1171-8.
2003: Chris Cheadle; Yoon S Cho-Chung; Kevin G Becker; Marquis P Vawter
Application of z-score transformation to Affymetrix data.
Applied bioinformatics 2003;2(4):209-17.
2003: Yoon S Cho-Chung
cAMP signaling in cancer genesis and treatment.
Cancer treatment and research 2003;115():123-43.
2002: Yee Sook Cho; Meyoung-Kon Kim; Chris Cheadle; Catherine Neary; Yun Gyu Park; Kevin G Becker; Yoon S Cho-Chung
A genomic-scale view of the cAMP response element-enhancer decoy: a tumor target-based genetic tool.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(24):15626-31.
2002: Yoon S Cho-Chung
Antisense DNAs as targeted therapeutics for cancer: no longer a dream.
Current opinion in investigational drugs (London, England : 2000) 2002;3(6):934-9.
2002: Yoon S Cho-Chung; Maria V Nesterova; Kevin G Becker; Rakesh K Srivastava; Yun Gyu Park; Youl-Nam Lee; Yee Sook Cho; Meyoung-Kin Kim; Catherine Neary; Chris Cheadle
Dissecting the circuitry of protein kinase A and cAMP signaling in cancer genesis: antisense, microarray, gene overexpression, and transcription factor decoy.
Annals of the New York Academy of Sciences 2002;968():22-36.
2002: Constantine Straturis; Yoon S Cho-Chung
Protein kinase A and human disease.
Trends in endocrinology and metabolism: TEM 2002;13(2):50-2.
2002: Yee Sook Cho; Meyoung-Kon Kim; Langzhu Tan; Rakesh K Srivastava; Sudhir Agrawal; Yoon S Cho-Chung
Protein kinase A RIalpha antisense inhibition of PC3M prostate cancer cell growth: Bcl-2 hyperphosphorylation, Bax up-regulation, and Bad-hypophosphorylation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(2):607-14.
2001: Catherine Neary; Yoon S Cho-Chung
Nuclear translocation of the catalytic subunit of protein kinase A induced by an antisense oligonucleotide directed against the RIalpha regulatory subunit.
Oncogene 2001;20(55):8019-24.
2001: Yee Sook Cho; Meyoung-Kon Kim; Chris Cheadle; Catherine Neary; Kevin G Becker; Yoon S Cho-Chung
Antisense DNAs as multisite genomic modulators identified by DNA microarray.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(17):9819-23.
2001: Ozgül M Alper; Elke Bergmann-Leitner; Scott Abrams; Yoon S Cho-Chung
Apoptosis, growth arrest and suppression of invasiveness by CRE-decoy oligonucleotide in ovarian cancer cells: protein kinase A downregulation and cytoplasmic export of CRE-binding proteins.
Molecular and cellular biochemistry 2001;218(1-2):55-63.
2000: Maria V Nesterova; Yoon S Cho-Chung
Oligonucleotide sequence-specific inhibition of gene expression, tumor growth inhibition, and modulation of cAMP signaling by an RNA-DNA hybrid antisense targeted to protein kinase A RIalpha subunit.
Antisense & nucleic acid drug development 2000;10(6):423-33.
2000: Ozgül M Alper; ML De Santis; Kurt Stromberg; Neville F Hacker; Yoon S Cho-Chung; David S Salomon
Anti-sense suppression of epidermal growth factor receptor expression alters cellular proliferation, cell-adhesion and tumorigenicity in ovarian cancer cells.
International journal of cancer. Journal international du cancer 2000;88(4):566-74.
2000: Yoon S Cho-Chung; Yun Gyu Park; Maria V Nesterova; Youl-Nam Lee; Y S Cho
CRE-decoy oligonucleotide-inhibition of gene expression and tumor growth.
Molecular and cellular biochemistry 2000;212(1-2):29-34.
2000: Maria V Nesterova; K Noguchi; Yun Gyu Park; Youl-Nam Lee; Yoon S Cho-Chung
Compensatory stabilization of RIIbeta protein, cell cycle deregulation, and growth arrest in colon and prostate carcinoma cells by antisense-directed down-regulation of protein kinase A RIalpha protein.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(9):3434-41.
2000: Lawrence S Kirschner; J Aidan Carney; Svetlana D Pack; SE Taymans; Christoforos Giatzakis; Y S Cho; Yoon S Cho-Chung; Constantine Straturis
Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex.
Nature genetics 2000;26(1):89-92.
2000: Y N Lee; Y G Park; Young Hun Choi; Y S Cho; Yoon S Cho-Chung
CRE-transcription factor decoy oligonucleotide inhibition of MCF-7 breast cancer cells: cross-talk with p53 signaling pathway.
Biochemistry 2000;39(16):4863-8.
2000: Yee Sook Cho; Yun Gyu Park; Y N Lee; Meyoung-Kon Kim; S Bates; L Tan; Yoon S Cho-Chung
Extracellular protein kinase A as a cancer biomarker: its expression by tumor cells and reversal by a myristate-lacking Calpha and RIIbeta subunit overexpression.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(2):835-40.
2000: Rakesh K Srivastava; A R Srivastave; Yoon S Cho-Chung
Synergistic effects of 8-Cl-cAMP and retinoic acids in the inhibition of growth and induction of apoptosis in ovarian cancer cells: induction of retinoic acid receptor beta.
Molecular and cellular biochemistry 2000;204(1-2):1-9.
1999: Yoon S Cho-Chung; Maria V Nesterova; S Pepe; GR Lee; K Noguchi; Rakesh K Srivastava; AR Srivastava; Ozgül M Alper; Yun Gyu Park; Youl-Nam Lee
Antisense DNA-targeting protein kinase A-RIA subunit: a novel approach to cancer treatment.
Frontiers in bioscience : a journal and virtual library 1999;4():D898-907.
1999: Ozgül M Alper; Neville F Hacker; Yoon S Cho-Chung
Protein kinase A-Ialpha subunit-directed antisense inhibition of ovarian cancer cell growth: crosstalk with tyrosine kinase signaling pathway.
Oncogene 1999;18(35):4999-5004.
1999: Rakesh K Srivastava; AR Srivastava; Yoon S Cho-Chung; Dan Longo
Synergistic effects of retinoic acid and 8-chloro-adenosine 3',5'-cyclic monophosphate on the regulation of retinoic acid receptor beta and apoptosis: involvement of mitochondria.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(7):1892-904.
1999: Yoon S Cho-Chung; Yun Gyu Park; Youl-Nam Lee
Oligonucleotides as transcription factor decoys.
Current opinion in molecular therapeutics 1999;1(3):386-92.
1999: Yoon S Cho-Chung
Antisense oligonucleotide inhibition of serine/threonine kinases: an innovative approach to cancer treatment.
Pharmacology & therapeutics 1999;82(2-3):437-49.
1999: GR Lee; S N Kim; K Noguchi; S D Park; S H Hong; Yoon S Cho-Chung
Ala99ser mutation in RI alpha regulatory subunit of protein kinase A causes reduced kinase activation by cAMP and arrest of hormone-dependent breast cancer cell growth.
Molecular and cellular biochemistry 1999;195(1-2):77-86.
1999: Rakesh K Srivastava; AR Srivastava; Prem Seth; S Agrawal; Yoon S Cho-Chung
Growth arrest and induction of apoptosis in breast cancer cells by antisense depletion of protein kinase A-RI alpha subunit: p53-independent mechanism of action.
Molecular and cellular biochemistry 1999;195(1-2):25-36.
1999: Rakesh K Srivastava; AR Srivastava; Yoon S Cho-Chung; Dan Longo
Synergistic effects of retinoic acid and 8-Cl-cAMP on apoptosis require caspase-3 activation in human ovarian cancer cells.
Oncogene 1999;18(9):1755-63.
1999: Yun Gyu Park; Maria V Nesterova; S Agrawal; Yoon S Cho-Chung
Dual blockade of cyclic AMP response element- (CRE) and AP-1-directed transcription by CRE-transcription factor decoy oligonucleotide. gene-specific inhibition of tumor growth.
The Journal of biological chemistry 1999;274(3):1573-80.
1999: AA Kondrashin; Maria V Nesterova; Yoon S Cho-Chung
Cyclic adenosine 3':5'-monophosphate-dependent protein kinase on the external surface of LS-174T human colon carcinoma cells.
Biochemistry 1999;38(1):172-9.
1998: K Noguchi; T Murata; Yoon S Cho-Chung
8-chloroadenosine 3',5'-monophosphate (8-Cl-cAMP) selectively eliminates protein kinase A type I to induce growth inhibition in c-ras-transformed fibroblasts.
European journal of cancer (Oxford, England : 1990) 1998;34(8):1260-7.
1998: Rakesh K Srivastava; Y N Lee; K Noguchi; Yun Gyu Park; M J Ellis; J S Jeong; S N Kim; Yoon S Cho-Chung
The RIIbeta regulatory subunit of protein kinase A binds to cAMP response element: an alternative cAMP signaling pathway.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):6687-92.
1998: AA Kondrashin; Maria V Nesterova; Yoon S Cho-Chung
Subcellular distribution of the R-subunits of cAMP-dependent protein kinase in LS-174T human colon carcinoma cells.
Biochemistry and molecular biology international 1998;45(2):237-44.
1998: Rakesh K Srivastava; AR Srivastava; S J Korsmeyer; Maria V Nesterova; Yoon S Cho-Chung; Dan Longo
Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase.
Molecular and cellular biology 1998;18(6):3509-17.
1998: Rakesh K Srivastava; AR Srivastava; Yun Gyu Park; S Agrawal; Yoon S Cho-Chung
Antisense depletion of RIalpha subunit of protein kinase A induces apoptosis and growth arrest in human breast cancer cells.
Breast cancer research and treatment 1998;49(2):97-107.
1998: Yoon S Cho-Chung
CRE-palindrome oligonucleotide as a transcription factor decoy and an inhibitor of tumor growth.
Antisense & nucleic acid drug development 1998;8(2):167-70.
1998: Rakesh K Srivastava; AR Srivastava; Yoon S Cho-Chung
Synergistic effects of 8-chlorocyclic-AMP and retinoic acid on induction of apoptosis in Ewing's sarcoma CHP-100 cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(3):755-61.
1997: Yoon S Cho-Chung; Maria V Nesterova; AA Kondrashin; K Noguchi; Rakesh K Srivastava; S Pepe
Antisense-protein kinase A: a single-gene-based therapeutic approach.
Antisense & nucleic acid drug development 1997;7(3):217-23.
1997: Yoon S Cho-Chung
Antisense DNA toward type I protein kinase A produces sustained inhibition of tumor growth.
Proceedings of the Association of American Physicians 1997;109(1):23-32.
1996: Maria V Nesterova; H Yokozaki; E McDuffie; Yoon S Cho-Chung
Overexpression of RII beta regulatory subunit of protein kinase A in human colon carcinoma cell induces growth arrest and phenotypic changes that are abolished by site-directed mutation of RII beta.
European journal of biochemistry / FEBS 1996;235(3):486-94.
1996: Yoon S Cho-Chung
Protein kinase A-directed antisense restrains cancer growth: sequence-specific inhibition of gene expression.
Antisense & nucleic acid drug development 1996;6(3):237-44.
1995: Alfredo Budillon; A Cereseto; A Kondrashin; Maria V Nesterova; GR Merlo; Timothy Clair; Yoon S Cho-Chung
Point mutation of the autophosphorylation site or in the nuclear location signal causes protein kinase A RII beta regulatory subunit to lose its ability to revert transformed fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(23):10634-8.
1995: Yoon S Cho-Chung; Stefano Pepe; Timothy Clair; Alfredo Budillon; Maria V Nesterova
cAMP-dependent protein kinase: role in normal and malignant growth.
Critical reviews in oncology/hematology 1995;21(1-3):33-61.
1995: S Scala; Alfredo Budillon; Zhirong Zhan; Yoon S Cho-Chung; J Jefferson; M Tsokos; Susan E Bates
Downregulation of mdr-1 expression by 8-Cl-cAMP in multidrug resistant MCF-7 human breast cancer cells.
The Journal of clinical investigation 1995;96(2):1026-34.
1995: Maria V Nesterova; Yoon S Cho-Chung
A single-injection protein kinase A-directed antisense treatment to inhibit tumour growth.
Nature medicine 1995;1(6):528-33.
1994: Giampaolo Tortora; Stefano Pepe; C Bianco; Vincenzo Damiano; A Ruggiero; Gustavo Baldassarre; C Corbo; Yoon S Cho-Chung; Angelo Raffaele Bianco; Fortunato Ciardiello
Differential effects of protein kinase A sub-units on Chinese-hamster-ovary cell cycle and proliferation.
International journal of cancer. Journal international du cancer 1994;59(5):712-6.
1994: Giampaolo Tortora; Stefano Pepe; C Bianco; Gustavo Baldassarre; Alfredo Budillon; Timothy Clair; Yoon S Cho-Chung; Angelo Raffaele Bianco; Fortunato Ciardiello
The RI alpha subunit of protein kinase A controls serum dependency and entry into cell cycle of human mammary epithelial cells.
Oncogene 1994;9(11):3233-40.
1994: Giampaolo Tortora; Alfredo Budillon; H Yokozaki; Timothy Clair; Stefano Pepe; GR Merlo; C Rohlff; Yoon S Cho-Chung
Retroviral vector-mediated overexpression of the RII beta subunit of the cAMP-dependent protein kinase induces differentiation in human leukemia cells and reverts the transformed phenotype of mouse fibroblasts.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994;5(7):753-9.
1994: Stefano Pepe; A Ruggiero; Giampaolo Tortora; Fortunato Ciardiello; C Garbi; H Yokozaki; Yoon S Cho-Chung; Timothy Clair; B S Skalhegg; Angelo Raffaele Bianco
Flow-cytometric detection of the RI alpha subunit of type I cAMP-dependent protein kinase in human cells.
Cytometry 1994;15(1):73-9.
1993: Yoon S Cho-Chung; Timothy Clair
The regulatory subunit of cAMP-dependent protein kinase as a target for chemotherapy of cancer and other cellular dysfunctional-related diseases.
Pharmacology & therapeutics 1993;60(2):265-88.
1993: Giampaolo Tortora; Stefano Pepe; Anna Maria Cirafici; Fortunato Ciardiello; Antonio Porcellini; Timothy Clair; Giulia Colletta; Yoon S Cho-Chung; A R Bianco
Thyroid-stimulating hormone-regulated growth and cell cycle distribution of thyroid cells involve type I isozyme of cyclic AMP-dependent protein kinase.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993;4(5):359-65.
1993: C Rohlff; Timothy Clair; Yoon S Cho-Chung
8-Cl-cAMP induces truncation and down-regulation of the RI alpha subunit and up-regulation of the RII beta subunit of cAMP-dependent protein kinase leading to type II holoenzyme-dependent growth inhibition and differentiation of HL-60 leukemia cells.
The Journal of biological chemistry 1993;268(8):5774-82.
1993: C Rohlff; B Safa; Aquilur Rahman; Yoon S Cho-Chung; R W Klecker; Robert I Glazer
Reversal of resistance to adriamycin by 8-chloro-cyclic AMP in adriamycin-resistant HL-60 leukemia cells is associated with reduction of type I cyclic AMP-dependent protein kinase and cyclic AMP response element-binding protein DNA-binding activities.
Molecular pharmacology 1993;43(3):372-9.
1993: H Yokozaki; Alfredo Budillon; Giampaolo Tortora; S Meissner; S L Beaucage; K Miki; Yoon S Cho-Chung
An antisense oligodeoxynucleotide that depletes RI alpha subunit of cyclic AMP-dependent protein kinase induces growth inhibition in human cancer cells.
Cancer research 1993;53(4):868-72.
1992: A Pinto; Donatella Aldinucci; Valter Gattei; Vittorina Zagonel; Giampaolo Tortora; Alfredo Budillon; Yoon S Cho-Chung
Inhibition of the self-renewal capacity of blast progenitors from acute myeloblastic leukemia patients by site-selective 8-chloroadenosine 3',5'-cyclic monophosphate.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(19):8884-8.
1992: Yoon S Cho-Chung
Suppression of malignancy targeting cyclic AMP signal transducing proteins.
Biochemical Society transactions 1992;20(2):425-30.
1992: H Yokozaki; Giampaolo Tortora; Stefano Pepe; Erik Maronde; Hans-Gottfried Genieser; B Jastorff; Yoon S Cho-Chung
Unhydrolyzable analogues of adenosine 3':5'-monophosphate demonstrating growth inhibition and differentiation in human cancer cells.
Cancer research 1992;52(9):2504-8.
1991: Stefano Pepe; Giampaolo Tortora; P D Noguchi; Gerald E Marti; G C Washington; Yoon S Cho-Chung
Effects of 8-chloroadenosine 3',5'-monophosphate and N6-benzyl-cyclic adenosine 5'-monophosphate on cell cycle kinetics of HL-60 leukemia cells.
Cancer research 1991;51(23 Pt 1):6263-7.
1991: Yoon S Cho-Chung; Maria V Nesterova; E S Severin; S V Vinogradov
Chemical modification enhances the inhibitory effect of regulatory subunit antisense oligodeoxynucleotide of cAMP-dependent protein kinase type I on cell proliferation.
Biochemistry international 1991;25(4):767-73.
1991: Giampaolo Tortora; Stefano Pepe; H Yokozaki; S Meissner; Yoon S Cho-Chung
Cooperative effect of 8-Cl-cAMP and rhGM-CSF on the differentiation of HL-60 human leukemia cells.
Biochemical and biophysical research communications 1991;177(3):1133-40.
1991: Fiorella Guadagni; Giampaolo Tortora; Mario Roselli; Timothy Clair; Yoon S Cho-Chung; Jeffrey Schlom; John W Greiner
Carcinoembryonic antigen regulation in human colorectal tumor cells by a site-selective cyclic AMP analogue: a comparison with interferon-gamma.
International journal of cancer. Journal international du cancer 1991;48(3):413-22.
1991: Giampaolo Tortora; H Yokozaki; Stefano Pepe; Timothy Clair; Yoon S Cho-Chung
Differentiation of HL-60 leukemia by type I regulatory subunit antisense oligodeoxynucleotide of cAMP-dependent protein kinase.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(5):2011-5.
1991: Yoon S Cho-Chung; Timothy Clair; Giampaolo Tortora; H Yokozaki; Stefano Pepe
Suppression of malignancy targeting the intracellular signal transducing proteins of cAMP: the use of site-selective cAMP analogs, antisense strategy, and gene transfer.
Life sciences 1991;48(12):1123-32.
1991: Yoon S Cho-Chung; Timothy Clair; Giampaolo Tortora; H Yokozaki
Role of site-selective cAMP analogs in the control and reversal of malignancy.
Pharmacology & therapeutics 1991;50(1):1-33.
1990: Yoon S Cho-Chung
Role of cyclic AMP receptor proteins in growth, differentiation, and suppression of malignancy: new approaches to therapy.
Cancer research 1990;50(22):7093-100.
1990: Giampaolo Tortora; Yoon S Cho-Chung
Type II regulatory subunit of protein kinase restores cAMP-dependent transcription in a cAMP-unresponsive cell line.
The Journal of biological chemistry 1990;265(30):18067-70.
1990: Fortunato Ciardiello; Giampaolo Tortora; N Kim; Timothy Clair; S Ally; David S Salomon; Yoon S Cho-Chung
8-Chloro-cAMP inhibits transforming growth factor alpha transformation of mammary epithelial cells by restoration of the normal mRNA patterns for cAMP-dependent protein kinase regulatory subunit isoforms which show disruption upon transformation.
The Journal of biological chemistry 1990;265(2):1016-20.
1990: Giampaolo Tortora; Timothy Clair; Yoon S Cho-Chung
An antisense oligodeoxynucleotide targeted against the type II beta regulatory subunit mRNA of protein kinase inhibits cAMP-induced differentiation in HL-60 leukemia cells without affecting phorbol ester effects.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(2):705-8.
1989: S Ally; Timothy Clair; D Katsaros; Giampaolo Tortora; H Yokozaki; R A Finch; T L Avery; Yoon S Cho-Chung
Inhibition of growth and modulation of gene expression in human lung carcinoma in athymic mice by site-selective 8-Cl-cyclic adenosine monophosphate.
Cancer research 1989;49(20):5650-5.
1989: MI Mednieks; H Yokozaki; GR Merlo; Giampaolo Tortora; Timothy Clair; S Ally; E Tahara; Yoon S Cho-Chung
Site-selective 8-Cl-cAMP which causes growth inhibition and differentiation increases DNA (CRE)-binding activity in cancer cells.
FEBS letters 1989;254(1-2):83-8.
1989: Yoon S Cho-Chung
Site-selective 8-chloro-cyclic adenosine 3',5'-monophosphate as a biologic modulator of cancer: restoration of normal control mechanisms.
Journal of the National Cancer Institute 1989;81(13):982-7.
1989: Giampaolo Tortora; Timothy Clair; D Katsaros; S Ally; Oscar R Colamonici; Leonard M Neckers; Pierosandro Tagliaferri; T Jahnsen; R K Robins; Yoon S Cho-Chung
Induction of megakaryocytic differentiation and modulation of protein kinase gene expression by site-selective cAMP analogs in K-562 human leukemic cells.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(8):2849-52.
1989: Giampaolo Tortora; Fortunato Ciardiello; S Ally; Timothy Clair; David S Salomon; Yoon S Cho-Chung
Site-selective 8-chloroadenosine 3',5'-cyclic monophosphate inhibits transformation and transforming growth factor alpha production in Ki-ras-transformed rat fibroblasts.
FEBS letters 1989;242(2):363-7.
1989: Yoon S Cho-Chung; Timothy Clair; Pierosandro Tagliaferri; S Ally; D Katsaros; Giampaolo Tortora; Len Neckers; T L Avery; G W Crabtree; R K Robins
Site-selective cyclic AMP analogs as new biological tools in growth control, differentiation, and proto-oncogene regulation.
Cancer investigation 1989;7(2):161-77.
1988: S Ally; Domenico Grieco; Timothy Clair; D Grieco; GR Merlo; D Katsaros; D Ogreid; S O Døskeland; T Jahnsen; Yoon S Cho-Chung
Selective modulation of protein kinase isozymes by the site-selective analog 8-chloroadenosine 3',5'-cyclic monophosphate provides a biological means for control of human colon cancer cell growth.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(17):6319-22.
1988: D Katsaros; S Ally; Yoon S Cho-Chung
Site-selective cyclic AMP analogues are antagonistic to estrogen stimulation of growth and proto-oncogene expression in human breast-cancer cells.
International journal of cancer. Journal international du cancer 1988;41(6):863-7.
1988: Pierosandro Tagliaferri; D Katsaros; Timothy Clair; Len Neckers; R K Robins; Yoon S Cho-Chung
Reverse transformation of Harvey murine sarcoma virus-transformed NIH/3T3 cells by site-selective cyclic AMP analogs.
The Journal of biological chemistry 1988;263(1):409-16.
1987: Timothy Clair; S Ally; Pierosandro Tagliaferri; R K Robins; Yoon S Cho-Chung
Site-selective cAMP analogs induce nuclear translocation of the RII cAMP receptor protein in Ha-MuSV-transformed NIH/3T3 cells.
FEBS letters 1987;224(2):377-84.
1987: D Katsaros; Giampaolo Tortora; Pierosandro Tagliaferri; Timothy Clair; S Ally; Len Neckers; R K Robins; Yoon S Cho-Chung
Site-selective cyclic AMP analogs provide a new approach in the control of cancer cell growth.
FEBS letters 1987;223(1):97-103.
1987: Timothy Clair; W R Miller; Yoon S Cho-Chung
Prognostic significance of the expression of a ras protein with a molecular weight of 21,000 by human breast cancer.
Cancer research 1987;47(20):5290-3.