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Ian Alexander

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TOP 3
A P Dane; S J Wowro; Sharon C Cunningham; Ian E Alexander
Comparison of gene transfer to the murine liver following intraperitoneal and intraportal delivery of hepatotropic AAV pseudo-serotypes.
Samantha L Ginn; Mohammad R Abedi; Ian E Alexander; Michael L Edelstein; Jo Wixon
Gene therapy clinical trials worldwide to 2012 - an update.
Grant J Logan; Ian E Alexander
Adeno-associated virus vectors: immunobiology and potential use for immune modulation.

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All Publications

2013: A P Dane; S J Wowro; Sharon C Cunningham; Ian E Alexander
Comparison of gene transfer to the murine liver following intraperitoneal and intraportal delivery of hepatotropic AAV pseudo-serotypes.
Gene therapy 2013;20(4):460-4.
2013: Samantha L Ginn; Mohammad R Abedi; Ian E Alexander; Michael L Edelstein; Jo Wixon
Gene therapy clinical trials worldwide to 2012 - an update.
The journal of gene medicine 2013;15(2):65-77.
2012: Grant J Logan; Ian E Alexander
Adeno-associated virus vectors: immunobiology and potential use for immune modulation.
Current gene therapy 2012;12(4):333-43.
2012: Ian E Alexander; Allison P Dane; Cindy Kok; Sharon C Cunningham
Gene therapy for metabolic disorders: an overview with a focus on urea cycle disorders.
Journal of inherited metabolic disease 2012;35(4):641-5.
2012: Samantha L Ginn; Ian E Alexander
Gene therapy: progress in childhood disease.
Journal of paediatrics and child health 2012;48(6):466-71.
2011: Sharon C Cunningham; Cindy Y Kok; Allison P Dane; Kevin Carpenter; Eddy Kizana; Philip W Kuchel; Ian E Alexander
Induction and prevention of severe hyperammonemia in the spfash mouse model of ornithine transcarbamylase deficiency using shRNA and rAAV-mediated gene delivery.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(5):854-9.
2010: Samantha L Ginn; Sophia H Y Liao; Allison P Dane; Min Hu; Jessica Hyman; John W Finnie; Maolin Zheng; Marina Cavazzana-Calvo; Stephen I Alexander; Adrian J Thrasher; Ian E Alexander
Lymphomagenesis in SCID-X1 mice following lentivirus-mediated phenotype correction independent of insertional mutagenesis and gammac overexpression.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(5):965-76.
2010: Grant J Logan; Lina Wang; Maolin Zheng; Ross L Coppel; Ian E Alexander
Antigen fusion with C3d3 augments or inhibits humoral immunity to AAV genetic vaccines in a transgene-dependent manner.
Immunology and cell biology 2010;88(2):228-32.
2009: Claire T Deakin; Ian E Alexander; Ian Kerridge
Accepting risk in clinical research: is the gene therapy field becoming too risk-averse?
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(11):1842-8.
2009: Allison P Dane; Sharon C Cunningham; Nicole S Graf; Ian E Alexander
Sexually dimorphic patterns of episomal rAAV genome persistence in the adult mouse liver and correlation with hepatocellular proliferation.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(9):1548-54.
2009: Sharon C Cunningham; Afroditi Spinoulas; Kevin H Carpenter; Bridget Wilcken; Philip W Kuchel; Ian E Alexander
AAV2/8-mediated correction of OTC deficiency is robust in adult but not neonatal Spf(ash) mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(8):1340-6.
2009: Samantha L Ginn; Sharon C Cunningham; Maolin Zheng; A Spinoulas; K H Carpenter; Ian E Alexander
In vivo assessment of mutations in OTC for dominant-negative effects following rAAV2/8-mediated gene delivery to the mouse liver.
Gene therapy 2009;16(6):820-3.
2009: Antonio S J Lee; Prathibha Kahatapitiya; Belinda Kramer; Josephine E Joya; Jeff Hook; Renjing Liu; Galina Schevzov; Ian E Alexander; Geoff McCowage; Didier Montarras; Peter W Gunning; Edna C Hardeman
Methylguanine DNA methyltransferase-mediated drug resistance-based selective enrichment and engraftment of transplanted stem cells in skeletal muscle.
Stem cells (Dayton, Ohio) 2009;27(5):1098-108.
2009: Grant J Logan; L Wang; Maolin Zheng; Samantha L Ginn; Ross Coppel; Ian E Alexander
Antigen-specific humoral tolerance or immune augmentation induced by intramuscular delivery of adeno-associated viruses encoding CTLA4-Ig-antigen fusion molecules.
Gene therapy 2009;16(2):200-10.
2008: Sharon C Cunningham; Allison P Dane; Afroditi Spinoulas; Grant J Logan; Ian E Alexander
Gene delivery to the juvenile mouse liver using AAV2/8 vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(6):1081-8.
2008: Ian E Alexander; Sharon C Cunningham; Grant J Logan; J Christodoulou
Potential of AAV vectors in the treatment of metabolic disease.
Gene therapy 2008;15(11):831-9.
2008: J A Curtin; A P Dane; A Swanson; Ian E Alexander; Samantha L Ginn
Bidirectional promoter interference between two widely used internal heterologous promoters in a late-generation lentiviral construct.
Gene therapy 2008;15(5):384-90.
2007: Priyadarshini L Ganesan; Stephen I Alexander; Debbie Watson; Grant J Logan; Geoff Y Zhang; Ian E Alexander
Robust anti-tumor immunity and memory in Rag-1-deficient mice following adoptive transfer of cytokine-primed splenocytes and tumor CD80 expression.
Cancer immunology, immunotherapy : CII 2007;56(12):1955-65.
2007: Christine M Smyth; Samantha L Ginn; Claire T Deakin; Grant J Logan; Ian E Alexander
Limiting {gamma}c expression differentially affects signaling via the interleukin (IL)-7 and IL-15 receptors.
Blood 2007;110(1):91-8.
2007: Eddy Kizana; Connie Y Chang; Eugenio Cingolani; Genaro A Ramirez Correa; Rajesh B Sekar; ROSELLE ABRAHAM; Samantha L Ginn; Leslie Tung; Ian E Alexander; Eduardo Marban
Gene transfer of connexin43 mutants attenuates coupling in cardiomyocytes: novel basis for modulation of cardiac conduction by gene therapy.
Circulation research 2007;100(11):1597-604.
2007: Ze-Yan Yu; Karen McKay; Peter P Van Asperen; Maolin Zheng; Jane Fleming; Samantha L Ginn; Eddy Kizana; Margot Latham; Michael P Feneley; Peter D Kirkland; Peter B Rowe; Eugenie R Lumbers; Ian E Alexander
Lentivirus vector-mediated gene transfer to the developing bronchiolar airway epithelium in the fetal lamb.
The journal of gene medicine 2007;9(6):429-39.
2007: Sandra T Cooper; Eddy Kizana; Jonathon D Yates; Harriet Lo; Nan Yang; Zhan He Wu; Ian E Alexander; Kathryn N North
Dystrophinopathy carrier determination and detection of protein deficiencies in muscular dystrophy using lentiviral MyoD-forced myogenesis.
Neuromuscular disorders : NMD 2007;17(4):276-84.
2007: Grant J Logan; Lina Wang; Maolin Zheng; Sharon C Cunningham; Ross Coppel; Ian E Alexander
AAV vectors encoding malarial antigens stimulate antigen-specific immunity but do not protect from parasite infection.
Vaccine 2007;25(6):1014-22.
2006: Eddy Kizana; Samantha L Ginn; C M Smyth; A Boyd; S P Thomas; D G Allen; David L Ross; Ian E Alexander
Fibroblasts modulate cardiomyocyte excitability: implications for cardiac gene therapy.
Gene therapy 2006;13(22):1611-5.
2006: Belinda A Kramer; Frances A Lemckert; Ian E Alexander; Peter W Gunning; Geoffrey B McCowage
Characterisation of a P140K mutant O6-methylguanine-DNA-methyltransferase (MGMT)-expressing transgenic mouse line with drug-selectable bone marrow.
The journal of gene medicine 2006;8(9):1071-85.
2006: Yuan Min Wang; Geoff Yu Zhang; Yiping Wang; Min Hu; Huiling Wu; Debbie Watson; Shohei Hori; Ian E Alexander; David C H Harris; Stephen I Alexander
Foxp3-transduced polyclonal regulatory T cells protect against chronic renal injury from adriamycin.
Journal of the American Society of Nephrology : JASN 2006;17(3):697-706.
2005: Jane Fleming; Afroditi Spinoulas; Maolin Zheng; Sharon C Cunningham; Samantha L Ginn; Robert C McQuilty; Peter B Rowe; Ian E Alexander
Partial correction of sensitivity to oxidant stress in Friedreich ataxia patient fibroblasts by frataxin-encoding adeno-associated virus and lentivirus vectors.
Human gene therapy 2005;16(8):947-56.
2005: Samantha L Ginn; Julie A Curtin; Belinda Kramer; Christine M Smyth; Melanie Wong; Alyson Kakakios; Geoffrey B McCowage; Debbie Watson; Stephen I Alexander; Margot Latham; Sharon C Cunningham; Maolin Zheng; Linda Hobson; Peter B Rowe; Alain Fischer; Marina Cavazzana-Calvo; Salima Hacein-Bey-Abina; Ian E Alexander
Treatment of an infant with X-linked severe combined immunodeficiency (SCID-X1) by gene therapy in Australia.
The Medical journal of Australia 2005;182(9):458-63.
2005: Eddy Kizana; Samantha L Ginn; David G Allen; David L Ross; Ian E Alexander
Fibroblasts can be genetically modified to produce excitable cells capable of electrical coupling.
Circulation 2005;111(4):394-8.
2005: Christine M Smyth; Grant J Logan; Ross A Boadle; Peter B Rowe; Jason A Smythe; Ian E Alexander
Differential subcellular localization of CD86 in human PBMC-derived macrophages and DCs, and ultrastructural characterization by immuno-electron microscopy.
International immunology 2005;17(2):123-32.
2004: Samantha L Ginn; Christine M Smyth; Melanie Wong; Bruce Bennetts; Peter B Rowe; Ian E Alexander
A novel splice-site mutation in the common gamma chain (gammac) gene IL2RG results in X-linked severe combined immunodeficiency with an atypical NK+ phenotype.
Human mutation 2004;23(5):522-3.
2004: Grant J Logan; Afroditi Spinoulas; Stephen I Alexander; Jason A Smythe; Ian E Alexander
CD4 expression on EL4 cells as an epiphenomenon of retroviral transduction and selection.
Immunology and cell biology 2004;82(2):132-5.
2003: Eddy Kizana; Ian E Alexander
Cardiac gene therapy: therapeutic potential and current progress.
Current gene therapy 2003;3(5):418-51.
2003: Samantha L Ginn; Jane Fleming; Peter B Rowe; Ian E Alexander
Promoter interference mediated by the U3 region in early-generation HIV-1-derived lentivirus vectors can influence detection of transgene expression in a cell-type and species-specific manner.
Human gene therapy 2003;14(12):1127-37.
2003: Jane Fleming; Samantha L Ginn; Ian E Alexander
Dorsal root ganglia sensory neurons.
Methods in molecular biology (Clifton, N.J.) 2003;229():155-67.
2002: Grant J Logan; Christine M Smyth; John W Earl; Irina Zaikina; Peter B Rowe; Jason A Smythe; Ian E Alexander
HeLa cells cocultured with peripheral blood lymphocytes acquire an immuno-inhibitory phenotype through up-regulation of indoleamine 2,3-dioxygenase activity.
Immunology 2002;105(4):478-87.
2001: Jane Fleming; Samantha L Ginn; R P Weinberger; T N Trahair; Jason A Smythe; Ian E Alexander
Adeno-associated virus and lentivirus vectors mediate efficient and sustained transduction of cultured mouse and human dorsal root ganglia sensory neurons.
Human gene therapy 2001;12(1):77-86.
2000: T N Trahair; Ian E Alexander; Peter B Rowe; Jason A Smythe
The adenovirus E4 ORF6 and E1b 55 kDa proteins cooperate in a p53-independent manner to enhance transduction by recombinant adeno-associated virus vectors.
The Journal of general virology 2000;81(Pt 12):2983-91.
2000: A E Turnbull; A Skulimowski; Jason A Smythe; Ian E Alexander
Adeno-associated virus vectors show variable dependence on divalent cations for thermostability: implications for purification and handling.
Human gene therapy 2000;11(4):629-35.
1999: Jason A Smythe; P D Fink; Grant J Logan; J Lees; Peter B Rowe; Ian E Alexander
Human fibroblasts transduced with CD80 or CD86 efficiently trans-costimulate CD4+ and CD8+ T lymphocytes in HLA-restricted reactions: implications for immune augmentation cancer therapy and autoimmunity.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(6):3239-49.
1999: J Diao; Jason A Smythe; C Smyth; Peter B Rowe; Ian E Alexander
Human PBMC-derived dendritic cells transduced with an adenovirus vectorinduce cytotoxic T-lymphocyte responses against a vector-encoded antigen in vitro.
Gene therapy 1999;6(5):845-53.
1999: P D Fink; Ian E Alexander; Peter B Rowe; Jason A Smythe
Inhibition of human immunodeficiency virus type 1 replication by the K10-K42 peptide of GAP31 is due to induction of rapid but nonspecific precipitation of viral and nonviral proteins.
AIDS research and human retroviruses 1999;15(5):429-34.
1998: Christine M Smyth; Grant J Logan; R P Weinberger; Peter B Rowe; Ian E Alexander; Jason A Smythe
Identification of a dynamic intracellular reservoir of CD86 protein in peripheral blood monocytes that is not associated with the Golgi complex.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(11):5390-6.
1997: Ian E Alexander; D W Russell; A D Miller
Transfer of contaminants in adeno-associated virus vector stocks can mimic transduction and lead to artifactual results.
Human gene therapy 1997;8(16):1911-20.