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Les Choi

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Lia van Zuylen; John Bridgewater; Alex Sparreboom; Ferry A L M Eskens; Peter de Bruijn; Ivo Sklenar; A S T Planting; Les Choi; Douglas Bootle; Christian Mueller; Jonathan A Ledermann; Jaap Verweij
Phase I and pharmacokinetic study of the polyamine synthesis inhibitor SAM486A in combination with 5-fluorouracil/leucovorin in metastatic colorectal cancer.
Miklos Pless; Karim Belhadj; Hans D Menssen; Wolfgang Kern; Bertrand Coiffier; Jürgen Wolf; Richard Herrmann; Eckhard Thiel; Doug Bootle; Ivo Sklenar; Christian Müller; Les Choi; Carl Porter; Renaud Capdeville
Clinical efficacy, tolerability, and safety of SAM486A, a novel polyamine biosynthesis inhibitor, in patients with relapsed or refractory non-Hodgkin's lymphoma: results from a phase II multicenter study.
Lillian L Siu; Eric K Rowinsky; Lisa A Hammond; Geoffrey R Weiss; Manuel Hidalgo; Gary M Clark; Judy Moczygemba; Les Choi; Ron Linnartz; Nicholas C Barbet; Ivo Sklenar; Renaud Capdeville; Gregory Gan; Carl W Porter; Daniel Von Hoff; S Gail Eckhardt
A phase I and pharmacokinetic study of SAM486A, a novel polyamine biosynthesis inhibitor, administered on a daily-times-five every-three-week schedule in patients with Advanced solid malignancies.

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All Publications

2004: Lia van Zuylen; John Bridgewater; Alex Sparreboom; Ferry A L M Eskens; Peter de Bruijn; Ivo Sklenar; A S T Planting; Les Choi; Douglas Bootle; Christian Mueller; Jonathan A Ledermann; Jaap Verweij
Phase I and pharmacokinetic study of the polyamine synthesis inhibitor SAM486A in combination with 5-fluorouracil/leucovorin in metastatic colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(6):1949-55.
2004: Miklos Pless; Karim Belhadj; Hans D Menssen; Wolfgang Kern; Bertrand Coiffier; Jürgen Wolf; Richard Herrmann; Eckhard Thiel; Doug Bootle; Ivo Sklenar; Christian Müller; Les Choi; Carl Porter; Renaud Capdeville
Clinical efficacy, tolerability, and safety of SAM486A, a novel polyamine biosynthesis inhibitor, in patients with relapsed or refractory non-Hodgkin's lymphoma: results from a phase II multicenter study.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(4):1299-305.
2002: Lillian L Siu; Eric K Rowinsky; Lisa A Hammond; Geoffrey R Weiss; Manuel Hidalgo; Gary M Clark; Judy Moczygemba; Les Choi; Ron Linnartz; Nicholas C Barbet; Ivo Sklenar; Renaud Capdeville; Gregory Gan; Carl W Porter; Daniel Von Hoff; S Gail Eckhardt
A phase I and pharmacokinetic study of SAM486A, a novel polyamine biosynthesis inhibitor, administered on a daily-times-five every-three-week schedule in patients with Advanced solid malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(7):2157-66.
2001: Nicola C Levitt; Ferry A L M Eskens; KJ O'Byrne; David J Propper; LJ Denis; S J Owen; Les Choi; J A Foekens; Susan Wilner; J M Wood; M Nakajima; Denis C Talbot; W P Steward; Adrian L Harris; Jaap Verweij
Phase I and pharmacological study of the oral matrix metalloproteinase inhibitor, MMI270 (CGS27023A), in patients with advanced solid cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(7):1912-22.
2000: Robert Paridaens; D R Uges; Nicholas C Barbet; Les Choi; M Seeghers; W T van der Graaf; H J Groen; Herlinde Dumez; I V Buuren; F Muskiet; Renaud Capdeville; A T Oosterom; E G de Vries
A phase I study of a new polyamine biosynthesis inhibitor, SAM486A, in cancer patients with solid tumours.
British journal of cancer 2000;83(5):594-601.
2000: Ferry A L M Eskens; GA Greim; C van Zuylen; I Wolff; LJ Denis; A S T Planting; F A Muskiet; Jantien Wanders; Nicholas C Barbet; Les Choi; Renaud Capdeville; Jaap Verweij; Axel R Hanauske; U Bruntsch
Phase I and pharmacological study of weekly administration of the polyamine synthesis inhibitor SAM 486A (CGP 48 664) in patients with solid tumors. European Organization for Research and Treatment of Cancer Early Clinical Studies Group.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(5):1736-43.
2000: H Zhou; Les Choi; H Lau; U Bruntsch; E E Vries; G Eckhardt; A T Oosterom; Jaap Verweij; Horst Schran; Nicholas C Barbet; R Linnartz; Renaud Capdeville
Population pharmacokinetics/toxicodynamics (PK/TD) relationship of SAM486A in phase I studies in patients with advanced cancers.
Journal of clinical pharmacology 2000;40(3):275-83.
2000: Ferry A L M Eskens; Nicola C Levitt; Alex Sparreboom; Les Choi; R Mather; Jaap Verweij; Adrian L Harris
Effect of food on the pharmacokinetics of oral MMI270B (CGS 27023A), a novel matrix metalloproteinase inhibitor.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(2):431-3.