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Ewa Chojnacka-Wójcik

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Anna Czopek; Hanna Byrtus; Marcin Kołaczkowski; Maciej Pawłowski; Małgorzata Dybała; Gabriel Nowak; Ewa Tatarczyńska; Anna Wesołowska; Ewa Chojnacka-Wójcik
Synthesis and pharmacological evaluation of new 5-(cyclo)alkyl-5-phenyl- and 5-spiroimidazolidine-2,4-dione derivatives. Novel 5-HT1A receptor agonist with potential antidepressant and anxiolytic activity.
Agnieszka Zagórska; Slawomir Jurczyk; Maciej Pawłowski; Małgorzata Dybała; Gabriel Nowak; Ewa Tatarczyńska; Agnieszka Nikiforuk; Ewa Chojnacka-Wójcik
Synthesis and preliminary pharmacological evaluation of imidazo[2,1-f]purine-2,4-dione derivatives.
Maria H Paluchowska; Ryszard Bugno; Beata Duszyńska; Ewa Tatarczyńska; Agnieszka Nikiforuk; Tomasz Lenda; Ewa Chojnacka-Wójcik
The influence of modifications in imide fragment structure on 5-HT(1A) and 5-HT(7) receptor affinity and in vivo pharmacological properties of some new 1-(m-trifluoromethylphenyl)piperazines.

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All Publications

2010: Anna Czopek; Hanna Byrtus; Marcin Kołaczkowski; Maciej Pawłowski; Małgorzata Dybała; Gabriel Nowak; Ewa Tatarczyńska; Anna Wesołowska; Ewa Chojnacka-Wójcik
Synthesis and pharmacological evaluation of new 5-(cyclo)alkyl-5-phenyl- and 5-spiroimidazolidine-2,4-dione derivatives. Novel 5-HT1A receptor agonist with potential antidepressant and anxiolytic activity.
European journal of medicinal chemistry 2010;45(4):1295-303.
2009: Agnieszka Zagórska; Slawomir Jurczyk; Maciej Pawłowski; Małgorzata Dybała; Gabriel Nowak; Ewa Tatarczyńska; Agnieszka Nikiforuk; Ewa Chojnacka-Wójcik
Synthesis and preliminary pharmacological evaluation of imidazo[2,1-f]purine-2,4-dione derivatives.
European journal of medicinal chemistry 2009;44(11):4288-96.
2007: Maria H Paluchowska; Ryszard Bugno; Beata Duszyńska; Ewa Tatarczyńska; Agnieszka Nikiforuk; Tomasz Lenda; Ewa Chojnacka-Wójcik
The influence of modifications in imide fragment structure on 5-HT(1A) and 5-HT(7) receptor affinity and in vivo pharmacological properties of some new 1-(m-trifluoromethylphenyl)piperazines.
Bioorganic & medicinal chemistry 2007;15(22):7116-25.
2007: Anna Partyka; Aleksandra Kłodzińska; Bernadeta Szewczyk; Joanna M Wierońska; Ewa Chojnacka-Wójcik; Tadeusz Librowski; Barbara Filipek; Gabriel Nowak; Andrzej Pilc
Effects of GABAB receptor ligands in rodent tests of anxiety-like behavior.
Pharmacological reports : PR 2007;59(6):757-62.
2007: Katarzyna Stachowicz; K Gołembiowska; Magdalena Sowa-Kućma; Gabriel Nowak; Ewa Chojnacka-Wójcik; Andrzej Pilc
Anxiolytic-like action of MTEP expressed in the conflict drinking Vogel test in rats is serotonin dependent.
Neuropharmacology 2007;53(6):741-8.
2007: Pawel Zajdel; Gilles Subra; Andrzej Jacek Bojarski; Beata Duszyńska; Ewa Tatarczyńska; Agnieszka Nikiforuk; Ewa Chojnacka-Wójcik; Maciej Pawłowski; Jean Martinez
Novel class of arylpiperazines containing N-acylated amino acids: their synthesis, 5-HT1A, 5-HT2A receptor affinity, and in vivo pharmacological evaluation.
Bioorganic & medicinal chemistry 2007;15(8):2907-19.
2007: Katarzyna Stachowicz; Ewa Chojnacka-Wójcik; K Kłak; Andrzej Pilc
Anxiolytic-like effect of group III mGlu receptor antagonist is serotonin-dependent.
Neuropharmacology 2007;52(2):306-12.
2007: Anna Wesołowska; Ewa Tatarczyńska; Agnieszka Nikiforuk; Ewa Chojnacka-Wójcik
Enhancement of the anti-immobility action of antidepressants by a selective 5-HT7 receptor antagonist in the forced swimming test in mice.
European journal of pharmacology 2007;555(1):43-7.
2006: Katarzyna Stachowicz; Ewa Chojnacka-Wójcik; Kinga Kłak; Andrzej Pilc
Anxiolytic-like effects of group III mGlu receptor ligands in the hippocampus involve GABAA signaling.
Pharmacological reports : PR 2006;58(6):820-6.
2006: A Wesołowska; Agnieszka Nikiforuk; Klaudia Michalska; Wanda Kisiel; Ewa Chojnacka-Wójcik
Analgesic and sedative activities of lactucin and some lactucin-like guaianolides in mice.
Journal of ethnopharmacology 2006;107(2):254-8.
2006: Maria H Paluchowska; Ryszard Bugno; Sijka Charakchieva-Minol; Andrzej Jacek Bojarski; Ewa Tatarczyńska; Ewa Chojnacka-Wójcik
Conformational restriction in novel NAN-190 and MP3022 analogs and their 5-HT(1A) receptor activity.
Archiv der Pharmazie 2006;339(9):498-506.
2006: Anna Wesołowska; Agnieszka Nikiforuk; Ewa Chojnacka-Wójcik
Anticonvulsant effect of the selective 5-HT1B receptor agonist CP 94253 in mice.
European journal of pharmacology 2006;541(1-2):57-63.
2006: Andrzej Jacek Bojarski; Maria H Paluchowska; Beata Duszyńska; Ryszard Bugno; Aleksandra Kłodzińska; Ewa Tatarczyńska; Ewa Chojnacka-Wójcik
Structure-intrinsic activity relationship studies in the group of 1-imido/amido substituted 4-(4-arylpiperazin-1-yl)cyclohexane derivatives; new, potent 5-HT1A receptor agents with anxiolytic- like activity.
Bioorganic & medicinal chemistry 2006;14(5):1391-402.
2005: Katarzyna Stachowicz; Kinga Kłak; Andrzej Pilc; Ewa Chojnacka-Wójcik
Lack of the antianxiety-like effect of (S)-3,4-DCPG, an mGlu8 receptor agonist, after central administration in rats.
Pharmacological reports : PR 2005;57(6):856-60.
2005: Hanna Byrtus; Maciej Pawłowski; Anna Czopek; Andrzej Jacek Bojarski; Beata Duszyńska; Gabriel Nowak; Aleksandra Kłodzińska; Ewa Tatarczyńska; Anna Wesołowska; Ewa Chojnacka-Wójcik
Synthesis and 5-HT(1A), 5-HT(2A) receptor activity of new beta-tetralonohydantoins.
European journal of medicinal chemistry 2005;40(8):820-9.
2005: Ewa Tatarczyńska; Lucyna Antkiewicz-Michaluk; Aleksandra Kłodzińska; Katarzyna Stachowicz; Ewa Chojnacka-Wójcik
Antidepressant-like effect of the selective 5-HT1B receptor agonist CP 94253: a possible mechanism of action.
European journal of pharmacology 2005;516(1):46-50.
2005: Andrzej Jacek Bojarski; Maria H Paluchowska; Beata Duszyńska; Aleksandra Kłodzińska; Ewa Tatarczyńska; Ewa Chojnacka-Wójcik
1-Aryl-4-(4-succinimidobutyl)piperazines and their conformationally constrained analogues: synthesis, binding to serotonin (5-HT1A, 5-HT2A, 5-HT7), alpha1-adrenergic, and dopaminergic D2 receptors, and in vivo 5-HT1A functional characteristics.
Bioorganic & medicinal chemistry 2005;13(6):2293-303.
2005: Maria H Paluchowska; Ryszard Bugno; Andrzej Jacek Bojarski; Sijka Charakchieva-Minol; Beata Duszyńska; Ewa Tatarczyńska; Aleksandra Kłodzińska; Katarzyna Stachowicz; Ewa Chojnacka-Wójcik
Novel, flexible, and conformationally defined analogs of gepirone: synthesis and 5-HT1A, 5-HT2A, and D2 receptor activity.
Bioorganic & medicinal chemistry 2005;13(4):1195-200.
2005: Ewa Chojnacka-Wójcik; Aleksandra Kłodzińska; Ewa Tatarczyńska
The anxiolytic-like effect of 5-HT1B receptor ligands in rats: a possible mechanism of action.
The Journal of pharmacy and pharmacology 2005;57(2):253-7.
2004: E Tatarczyńska; A Kłodzińska; Katarzyna Stachowicz; Ewa Chojnacka-Wójcik
Effects of a selective 5-HT1B receptor agonist and antagonists in animal models of anxiety and depression.
Behavioural pharmacology 2004;15(8):523-34.
2004: Maria H Paluchowska; Sijka Charakchieva-Minol; Ewa Tatarczyńska; Aleksandra Kłodzińska; Katarzyna Stachowicz; Ewa Chojnacka-Wójcik
New 4-[omega-(diarylmethylamino)alkyl]- and 4-[omega-(diarylmethoxy)alkyl]-1-arylpiperazines as selective 5-HT1A/5-HT2A receptor ligands with differentiated in vivo activity.
Polish journal of pharmacology 2004;56(6):743-54.
2004: Aleksandra Klodzinska; Ewa Tatarczyńska; Ewa Chojnacka-Wójcik; Gabriel Nowak; Nicholas Cosford; Andrzej Pilc
Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA(A) signaling.
Neuropharmacology 2004;47(3):342-50.
2004: Anna Agnieszka Strzelczyk; Malgorzata Jarończyk; Zdzislaw Chilmonczyk; Aleksander Pawel Mazurek; Ewa Chojnacka-Wójcik; Ingebrigt Sylte
Intrinsic activity and comparative molecular dynamics of buspirone analogues at the 5-HT(1A) receptors.
Biochemical pharmacology 2004;67(12):2219-30.
2004: Slawomir Jurczyk; Marcin Kołaczkowski; Ewa Maryniak; Pawel Zajdel; Maciej Pawłowski; Ewa Tatarczyńska; Aleksandra Kłodzińska; Ewa Chojnacka-Wójcik; Andrzej Jacek Bojarski; Sijka Charakchieva-Minol; Beata Duszyńska; Gabriel Nowak; Dorota Maciag
New arylpiperazine 5-HT(1A) receptor ligands containing the pyrimido[2,1-f]purine fragment: synthesis, in vitro, and in vivo pharmacological evaluation.
Journal of medicinal chemistry 2004;47(10):2659-66.
2004: Ewa Tatarczyńska; Aleksandra Kłodzińska; Katarzyna Stachowicz; Ewa Chojnacka-Wójcik
Effect of combined administration of 5-HT1A or 5-HT1B/1D receptor antagonists and antidepressants in the forced swimming test.
European journal of pharmacology 2004;487(1-3):133-42.
2004: A Kłodzińska; E Tatarczyńska; Katarzyna Stachowicz; Ewa Chojnacka-Wójcik
The anxiolytic-like activity of AIDA (1-aminoindan-1,5-dicarboxylic acid), an mGLu 1 receptor antagonist.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2004;55(1 Pt 1):113-26.
2004: Joanna M Wierońska; Maria Smiałowska; Piotr Brański; Fabrizio Gasparini; Aleksandra Kłodzińska; Bernadeta Szewczyk; Agnieszka Pałucha; Ewa Chojnacka-Wójcik; Andrzej Pilc
In the amygdala anxiolytic action of mGlu5 receptors antagonist MPEP involves neuropeptide Y but not GABAA signaling.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2004;29(3):514-21.
2004: A Pałucha; E Tatarczyńska; P Brański; Bernadeta Szewczyk; J M Wierońska; K Kłak; Ewa Chojnacka-Wójcik; Gabriel Nowak; Andrzej Pilc
Group III mGlu receptor agonists produce anxiolytic- and antidepressant-like effects after central administration in rats.
Neuropharmacology 2004;46(2):151-9.
2003: Jan Boksa; Sijka Charakchieva-Minol; Beata Duszyńska; Ryszard Bugno; Aleksandra Kłodzińska; Ewa Tatarczyńska; Ewa Chojnacka-Wójcik; Andrzej Jacek Bojarski
Synthesis, in vitro and in vivo 5-HT1A/5-HT2A serotonin receptor activity of new hybrid 1,2,3,4-tetrahydro-gamma-carbolines with 1-(2-methoxyphenyl)piperazine moiety.
Polish journal of pharmacology 2003;55(6):1013-9.
2003: Jolanta Obniska; Maciej Pawłowski; Marcin Kołaczkowski; Anna Czopek; Beata Duszyńska; Aleksandra Klodzińska; Ewa Tatarczyńska; Ewa Chojnacka-Wójcik
Synthesis and 5-HT1A/5-HT2A receptor activity of new N-[3-(4-phenylpiperazin-1-yl)-propyl] derivatives of 3-spiro-cyclohexanepyrrolidine-2,5-dione and 3-spiro-beta-tetralonepyrrolidine-2,5-dione.
Polish journal of pharmacology 2003;55(4):553-7.
2003: Maria H Paluchowska; Maria J Mokrosz; Sijka Charakchieva-Minol; Beata Duszyńska; Aneta Kozioł; Anna Wesołowska; Katarzyna Stachowicz; Ewa Chojnacka-Wójcik
Novel 4-alkyl-1-arylpiperazines and 1,2,3,4-tetrahydroisoquinolines containing diphenylmethylamino or diphenylmethoxy fragment with differentiated 5-HT1A/5-HT2A/D2 receptor activity.
Polish journal of pharmacology 2003;55(4):543-52.
2003: Anna Wesołowska; Maria H Paluchowska; Ewa Chojnacka-Wójcik
Involvement of presynaptic 5-HT(1A) and benzodiazepine receptors in the anticonflict activity of 5-HT(1A) receptor antagonists.
European journal of pharmacology 2003;471(1):27-34.
2003: Anna Wesołowska; Maria H Paluchowska; Krystyna Gołembiowska; Ewa Chojnacka-Wójcik
Pharmacological characterization of MP349, a novel 5-HT1A-receptor antagonist with anxiolytic-like activity, in mice and rats.
The Journal of pharmacy and pharmacology 2003;55(4):533-43.
2002: Andrzej Jacek Bojarski; Piotr Kowalski; Teresa Kowalska; Beata Duszyńska; Sijka Charakchieva-Minol; Ewa Tatarczyńska; Aleksandra Kłodzińska; Ewa Chojnacka-Wójcik
Synthesis and pharmacological evaluation of new arylpiperazines. 3-[4-[4-(3-chlorophenyl)-1-piperazinyl]butyl]-quinazolidin-4-one - a dual serotonin 5-HT(1A)/5-HT(2A) receptor ligand with an anxiolytic-like activity.
Bioorganic & medicinal chemistry 2002;10(12):3817-27.
2002: Ewa Tatarczyńska; Agnieszka Pałucha; Bernadeta Szewczyk; Ewa Chojnacka-Wójcik; Joanna Wierońska; Andrzej Pilc
Anxiolytic- and antidepressant-like effects of group III metabotropic glutamate agonist (1S,3R,4S)-1-aminocyclopentane-1,3,4-tricarboxylic acid (ACPT-I) in rats.
Polish journal of pharmacology 2002;54(6):707-10.
2002: Maria H Paluchowska; Ryszard Bugno; Sijka Charakchieva-Minol; Anna Wesołowska; Ewa Chojnacka-Wójcik
Novel N-[omega-[4-(2-methoxyphenyl)piperazin-1-yl]-ethyl]pyrid-2(1H)-ones with diversified 5-HT1A receptor activity.
Polish journal of pharmacology 2002;54(6):641-6.
2002: Ewa Tatarczyńska; Aleksandra Kłodzińska; Ewa Chojnacka-Wójcik
Effects of combined administration of 5-HT1A and/or 5-HT1B receptor antagonists and paroxetine or fluoxetine in the forced swimming test in rats.
Polish journal of pharmacology 2002;54(6):615-23.
2002: Andrzej Pilc; A Kłodzińska; P Brański; Gabriel Nowak; A Pałucha; Bernadeta Szewczyk; E Tatarczyńska; Ewa Chojnacka-Wójcik; J M Wierońska
Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats.
Neuropharmacology 2002;43(2):181-7.
2002: Anna Wesołowska; Janusz Borycz; Maria H Paluchowska; Ewa Chojnacka-Wójcik
Pharmacological analysis of the hypothermic effects of NAN-190 and its analogs, postsynaptic 5-HT1A receptor antagonists, in mice.
Polish journal of pharmacology 2002;54(4):391-9.
2002: Zdzislaw Chilmonczyk; Maria Mazgajska; Joanna Iskra-Jopa; Ewa Chojnacka-Wójcik; Ewa Tatarczyńska; Aleksandra Kłodziriska; Jerzy Z Nowak
Pharmacological properties and SAR of new 1,4-disubstituted piperazine derivatives with hypnotic-sedative activity.
The Journal of pharmacy and pharmacology 2002;54(5):689-98.
2002: Zdzislaw Chilmonczyk; Marcin Cybulski; Joanna Iskra-Jopa; Ewa Chojnacka-Wójcik; Ewa Tatarczyńska; Aleksandra Kłodzińska; Andrzej Leś; Agnieszka Bronowska; Ingebrigt Sylte
Interaction of 1,2,4-substituted piperazines, new serotonin receptor ligands, with 5-HT1A and 5-HT2A receptors.
Farmaco (Società chimica italiana : 1989) 2002;57(4):285-301.
2002: Andrzej Jacek Bojarski; Maria J Mokrosz; Sijka Charakchieva Minol; Aneta Kozioł; Anna Wesołowska; Ewa Tatarczyńska; Aleksandra Kłodzińska; Ewa Chojnacka-Wójcik
The influence of substitution at aromatic part of 1,2,3,4-tetrahydroisoquinoline on in vitro and in vivo 5-HT(1A)/5-HT(2A) receptor activities of its 1-adamantoyloaminoalkyl derivatives.
Bioorganic & medicinal chemistry 2002;10(1):87-95.
2001: E Tatarczyńska; A Kłodzińska; B Kroczka; Ewa Chojnacka-Wójcik; Andrzej Pilc
The antianxiety-like effects of antagonists of group I and agonists of group II and III metabotropic glutamate receptors after intrahippocampal administration.
Psychopharmacology 2001;158(1):94-9.
2001: Ewa Chojnacka-Wójcik; A Kłodzinska; A Pilc
Glutamate receptor ligands as anxiolytics.
Current opinion in investigational drugs (London, England : 2000) 2001;2(8):1112-9.
2001: Hanna Byrtus; M Pawłowski; B Duszyńska; A Wesołowska; Ewa Chojnacka-Wójcik; Andrzej Jacek Bojarski
Arylpiperazine derivatives of 3-propyl-beta-tetralonohydantoin as new 5-HT1A and 5-HT2A receptor ligands.
Polish journal of pharmacology 2001;53(4):395-401.
2001: G Chloń; M Pawłowski; B Duszyńska; A Szaro; E Tatarczńska; A L Kłodzińska; Ewa Chojnacka-Wójcik
Synthesis, 5-HT1A and 5-HT2A receptor activity of new 1-phenylpiperazinylpropyl derivatives with arylalkyl substituents in position 7 of purine-2,6-dione.
Polish journal of pharmacology 2001;53(4):359-68.
2001: Maria J Mokrosz; Sijka Charakchieva-Minol; A Kozioł; A Kłodzińska; Ewa Chojnacka-Wójcik
Influence of the terminal amide fragment geometry in some 3-arylideneindolin-2(1H)-ones on their 5-HT1A/5-HT2A receptor activity.
Bioorganic & medicinal chemistry letters 2001;11(9):1229-31.
2001: E Tatarczyńska; A Klodzińska; Ewa Chojnacka-Wójcik; Agnieszka Palucha; F Gasparini; R Kuhn; Andrzej Pilc
Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist.
British journal of pharmacology 2001;132(7):1423-30.
2000: A Kłodzińska; E Tatarczyńska; Ewa Chojnacka-Wójcik; Andrzej Pilc
Anxiolytic-like effects of group I metabotropic glutamate antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) in rats.
Polish journal of pharmacology 2000;52(6):463-6.
2000: A Klodzińska; Ewa Chojnacka-Wójcik
Anticonflict effect of the glycineB receptor partial agonist, D-cycloserine, in rats. Pharmacological analysis.
Psychopharmacology 2000;152(2):224-8.
2000: E Przegaliński; E Tatarczyńska; Ewa Chojnacka-Wójcik
The influence of the benzodiazepine receptor antagonist flumazenil on the anxiolytic-like effects of CGP 37849 and ACPC in rats.
Neuropharmacology 2000;39(10):1858-64.
2000: A Wesołowska; Janusz Borycz; Ewa Chojnacka-Wójcik; E Przegaliński
Lack of effect of repeated treatment with a glycineB receptor partial agonist on the amphetamine-induced hyperactivity in rats.
Polish journal of pharmacology 2000;52(3):203-7.
2000: A Kłodzińska; Maria Bijak; Ewa Chojnacka-Wójcik; B Kroczka; M Swiader; Stanislaw J Czuczwar; Andrzej Pilc
Roles of group II metabotropic glutamate receptors in modulation of seizure activity.
Naunyn-Schmiedeberg's archives of pharmacology 2000;361(3):283-8.
2000: Andrzej Pilc; Ewa Chojnacka-Wójcik; E Tatarczyńska; Janusz Borycz; B Kroczka
Stimulation of group II metabotropic glutamate receptors or inhibition of group I ones exerts anxiolytic-like effects in rats.
Amino acids 2000;19(1):81-6.
2000: Maria J Mokrosz; Sijka Charakchieva-Minol; A Kozioł; A Kłodzińska; Ewa Chojnacka-Wójcik
Synthesis and pharmacological characteristics of novel (Z)-3-arylidene-indolin-2(1H)-ones: preliminary results.
Polish journal of pharmacology 2000;52(1):47-50.
1999: Maria H Paluchowska; Maria J Mokrosz; Andrzej Jacek Bojarski; A Wesołowska; Janusz Borycz; Sijka Charakchieva-Minol; Ewa Chojnacka-Wójcik
On the bioactive conformation of NAN-190 (1) and MP3022 (2), 5-HT(1A) receptor antagonists.
Journal of medicinal chemistry 1999;42(24):4952-60.
1999: A Kłodzińska; Ewa Chojnacka-Wójcik; A Pałucha; P Brański; Piotr Popik; Andrzej Pilc
Potential anti-anxiety, anti-addictive effects of LY 354740, a selective group II glutamate metabotropic receptors agonist in animal models.
Neuropharmacology 1999;38(12):1831-9.
1999: A Kłodzińska; Ewa Chojnacka-Wójcik; Andrzej Pilc
Selective group II glutamate metabotropic receptor agonist LY354740 attenuates pentetrazole- and picrotoxin-induced seizures.
Polish journal of pharmacology 1999;51(6):543-5.
1999: Maria J Mokrosz; Piotr Kowalski; Teresa Kowalska; Z Majka; B Duszyńska; Andrzej Jacek Bojarski; A Fruziński; Janina Karolak-Wojciechowska; A Wesołowska; A Kłodzińska; E Tatarczyńska; Ewa Chojnacka-Wójcik
Structure-activity relationship studies of CNS agents. Part 38. Novel 1,4-benzoxazin-3(4H)-one, 1,2-benzoxazolin-3-one and 1,3-benzoxazolin-2,4-dione arylpiperazine derivatives with different 5-HT1A and antagonistic 5-HT2A activities.
Archiv der Pharmazie 1999;332(11):373-9.
1999: E Przegaliński; E Tatarczyńska; A Kłodzińska; Ewa Chojnacka-Wójcik
Tolerance to anxiolytic- and antidepressant-like effects of a partial agonist of glycineB receptors.
Pharmacology, biochemistry, and behavior 1999;64(3):461-6.
1999: Ewa Chojnacka-Wójcik; A Kłodzińska; E Tatarczyńska; Maria H Paluchowska
Some pharmacological properties of new analogs of MP 3022, the 5-HT1A receptor antagonist.
Polish journal of pharmacology 1999;51(5):405-13.
1999: E Przegaliński; Joanna Siwanowicz; Ewa Chojnacka-Wójcik
Lack of effect of a glycine(B) receptor partial agonist on amphetamine-induced sensitization in mice.
Polish journal of pharmacology 1999;51(5):385-90.
1999: Maria J Mokrosz; Andrzej Jacek Bojarski; B Duszyńska; E Tatarczyńska; A Kłodzińska; A Dereń-Wesołek; Sijka Charakchieva-Minol; Ewa Chojnacka-Wójcik
1,2,3,4-tetrahydroisoquinoline derivatives: a new class of 5-HT1A receptor ligands.
Bioorganic & medicinal chemistry 1999;7(2):287-95.
1998: Maria J Mokrosz; B Duszyńska; S Misztal; A Kłodzińska; E Tatarczyńska; Ewa Chojnacka-Wójcik; M Dziedzicka-Wasylewska
A search for new 5-HT1A/5-HT2A receptor ligands. In vitro and in vivo studies of 1-[omega-(4-aryl-1-piperazinyl)alkyl]indolin-2(1H)-ones.
Archiv der Pharmazie 1998;331(10):325-30.
1998: E Przegaliński; E Tatarczyńska; Ewa Chojnacka-Wójcik
Anxiolytic- and antidepressant-like effects of an antagonist at glycineB receptors.
Polish journal of pharmacology 1998;50(4-5):349-54.
1998: Maria H Paluchowska; A Kłodzińska; E Tatarczyńska; A Szaro; Ewa Chojnacka-Wójcik
Effect of linking bridge modifications on the 5-HT1A receptor activity of some 4-(omega-benzotriazol-1-yl)alkyl-1-(2-methoxy-phenyl)piperazines.
Polish journal of pharmacology 1998;50(4-5):341-7.
1998: Maria J Mokrosz; Piotr Kowalski; Teresa Kowalska; Z Majka; B Duszyńska; Sijka Charakchieva-Minol; A Szaro; E Tatarczyńska; A Kłodzińska; Ewa Chojnacka-Wójcik
1,4-Benzoxazin-3(4H)-one derivatives and related compounds as 5-HT1A and 5-HT2A receptor ligands; the effect of the terminal amide fragment on the 5-HT1A/5-HT2A affinity and functional activity.
Polish journal of pharmacology 1998;50(4-5):333-40.
1998: Ryszard Paruszewski; A Kłodzińska; Ewa Chojnacka-Wójcik
Potential anxiolytic-like activity of some amino acid derivatives.
Die Pharmazie 1998;53(2):124-5.
1998: A Dereń-Wesołek; E Tatarczyńska; Ewa Chojnacka-Wójcik
The novel buspirone analogue, 8-[4-[2-(1,2,3,4-tetrahydroisoquinolinyl)[butyl]-8-azaspiro [4.5 ]decane-7,9-dione, with anxiolytic-like and antidepressant-like effects in rats.
Journal of psychopharmacology (Oxford, England) 1998;12(4):380-4.
1997: Ewa Chojnacka-Wójcik; A Kłodzińska
Involvement of 5-hydroxytryptamine 2A (5-HT2A) receptors in the mediation of the discriminative stimulus properties of (+/-)DOI in rats.
Polish journal of pharmacology 1997;49(5):299-304.
1997: Maria J Mokrosz; J L Mokrosz; B Duszyńska; A Dereń-Wesołek; A Kłodzińska; Piotr Kowalski; Sijka Charakchieva-Minol; E Tatarczyńska; Teresa Kowalska; Z Majka; Ewa Chojnacka-Wójcik; S Misztal
5-HT1A and 5-HT2A receptor affinity and functional profile of some N-[3-(4-aryl-1-piperazinyl)propyl] derivatives of indolin-2(1H)-one, quinolin-2(1 H)-one and isoquinolin-1(2H)-one. Part 30: Structure-activity relationship studies of CNS agents.
Die Pharmazie 1997;52(6):423-8.
1997: Ewa Chojnacka-Wójcik; E Tatarczyńska; Andrzej Pilc
The anxiolytic-like effect of metabotropic glutamate receptor antagonists after intrahippocampal injection in rats.
European journal of pharmacology 1997;319(2-3):153-6.
1996: M T Cegła; Jan Boksa; Ewa Chojnacka-Wójcik; S Misztal
4-Aryl-1-piperazinylalkyl derivatives of 1,2,3,4-tetrahydro-beta-carboline ring system. Synthesis and preliminary in vivo studies.
Die Pharmazie 1996;51(12):932-6.
1996: Ewa Chojnacka-Wójcik; E Tatarczyńska; A Dereń-Wesołek
Effect of glycine on antidepressant- and anxiolytic-like action of 1-aminocyclopropanecarboxylic acid (ACPC) in rats.
Polish journal of pharmacology 1996;48(6):627-9.
1996: Maria H Paluchowska; A Dereń-Wesołek; J L Mokrosz; Sijka Charakchieva-Minol; Ewa Chojnacka-Wójcik
Structure-activity relationship studies of CNS agents, Part 31: Analogs of MP 3022 with a different number of nitrogen atoms in the heteroaromatic fragment--new 5-HT1A receptor ligands.
Archiv der Pharmazie 1996;329(10):451-6.
1996: Ewa Chojnacka-Wójcik; E Tatarczyńska; Andrzej Pilc
Anxiolytic-like effects of metabotropic glutamate antagonist (RS)-alpha-methylserine-O-phosphate in rats.
Polish journal of pharmacology 1996;48(5):507-9.
1996: E Przegaliński; E Tatarczyńska; A Dereń-Wesołek; Ewa Chojnacka-Wójcik
Anticonflict effects of a competitive NMDA receptor antagonist and a partial agonist at strychnine-insensitive glycine receptors.
Pharmacology, biochemistry, and behavior 1996;54(1):73-7.
1996: J L Mokrosz; A Dereń-Wesołek; E Tatarczyńska; B Duszyńska; Andrzej Jacek Bojarski; Maria J Mokrosz; Ewa Chojnacka-Wójcik
8-[4-[2-(1,2,3,4-Tetrahydroisoquinolinyl]butyl-8-azaspiro[4.5]decane-7,9-dione: a new 5-HT1A receptor ligand with the same activity profile as buspirone.
Journal of medicinal chemistry 1996;39(5):1125-9.
1996: Jan Boksa; A Klodzińska; Sijka Charakchieva-Minol; Ewa Chojnacka-Wójcik; J L Mokrosz
Structure-activity relationship studies of CNS agents. Part 24: New analogs of N-tert.-butyl-3-[4-(2-methoxyphenyl)-1-piperazinyl]-2-phenylpropanamide (WAY-100135).
Die Pharmazie 1996;51(2):72-6.
1995: Edmund Przegalinski; E Tatarczyńska; Ewa Chojnacka-Wójcik
The role of hippocampal 5-hydroxytryptamine 1A (5-HT1A) receptors in the anticonflict activity of beta-adrenoceptor antagonists.
Neuropharmacology 1995;34(9):1211-7.
1995: Maria J Mokrosz; Lucjan Strekowski; W X Kozak; B Duszyńska; Andrzej Jacek Bojarski; A Kłodzinska; A Czarny; M T Cegła; A Dereń-Wesoøek; Ewa Chojnacka-Wójcik
Structure-activity relationship studies of CNS agents, Part 25. 4,6-di(heteroaryl)-2-(N-methylpiperazino)pyrimidines as new, potent 5-HT2A receptor ligands: a verification of the topographic model.
Archiv der Pharmazie 1995;328(9):659-66.
1995: Ewa Chojnacka-Wójcik
5-Hydroxytryptamine in the central nervous system.
Polish journal of pharmacology 1995;47(3):219-35.
1995: J L Mokrosz; Aleksandra Klodzinska; Jan Boksa; Andrzej Jacek Bojarski; Beata Duszynska; Ewa Chojnacka-Wójcik
Structure-activity relationship studies of CNS agents, XXI: Two derivatives of 1-(o-methoxyphenyl)piperazine with an opposite function at 5-HT1A receptors.
Archiv der Pharmazie 1995;328(4):381-3.
1994: Ewa Chojnacka-Wójcik; A Kłodzińska; A Dereń-Wesołek
Involvement of 5-HT2C receptors in the m-CPP-induced antinociception in mice.
Polish journal of pharmacology 1994;46(5):423-8.
1994: E Przegaliński; E Tatarczyńska; A Kłodzińska; Ewa Chojnacka-Wójcik
The role of postsynaptic 5-HT1A receptors in the anticonflict effect of ipsapirone.
Neuropharmacology 1994;33(9):1109-15.
1994: J L Mokrosz; Maria H Paluchowska; Ewa Chojnacka-Wójcik; M Filip; Sijka Charakchieva-Minol; A Dereń-Wesołek; Maria J Mokrosz
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
Journal of medicinal chemistry 1994;37(17):2754-60.
1994: E Przegaliński; Malgorzata Filip; Ewa Chojnacka-Wójcik; E Tatarczyńska
The role of 5-hydroxytryptamine1A (5-HT1A) receptors in the anticonflict activity of beta-adrenoceptor antagonists.
Pharmacology, biochemistry, and behavior 1994;47(4):873-8.
1994: J L Mokrosz; Ewa Chojnacka-Wójcik; A Dereń-Wesołek; A Kłodzińska; M Maćkowiak; Z Bielecka; Maria H Paluchowska
Structure-activity relationship studies of CNS agents. XII. 1-[4-(4-aryl-1-piperazinyl)butyl]-3,4-dihydro-2(1H)-quinolinones: new 5-HT1A, 5-HT2 and D2 ligands with a potential antipsychotic activity.
Drug design and discovery 1994;11(3):197-203.
1994: E Przegaliński; Malgorzata Filip; Boguslawa Budziszewska; Ewa Chojnacka-Wójcik
Antagonism of (+)WAY 100135 to behavioral, hypothermic and corticosterone effects induced by 8-OH-DPAT.
Polish journal of pharmacology 1994;46(1-2):21-7.
1993: Malgorzata Filip; Ewa Chojnacka-Wójcik; E Przegaliński
Discriminative stimulus properties of (+)-oxaprotiline in rats.
Polish journal of pharmacology 1993;45(2):151-6.
1992: Ewa Chojnacka-Wójcik
Modulation of the 5-HT1C receptor-mediated behavior by 5-HT2, but not 5-HT1A, receptor activation.
Polish journal of pharmacology and pharmacy 1992;44(5):427-36.
1992: M Filip; L Baran; Joanna Siwanowicz; Ewa Chojnacka-Wójcik; E Przegaliński
The anxiolytic-like effects of 5-hydroxytryptamine3 (5-HT3) receptor antagonists.
Polish journal of pharmacology and pharmacy 1992;44(3):261-9.
1992: Ewa Chojnacka-Wójcik
Functional interaction between 5-HT1B and 5-HT1A or 5-HT2 receptors in mice.
Polish journal of pharmacology and pharmacy 1992;44(3):251-60.
1992: Jan Boksa; S Misztal; Ewa Chojnacka-Wójcik; L Gastoł-Lewińska; A Gródecka; J L Mokrosz
Structure-activity relationship studies of CNS agents. Part 4: 2-[3-(4-aryl-1-piperazinyl)propyl]-1,2,3,4-tetrahydro-beta-carbolin+ ++ -1-one derivatives as potential central anti-serotonin agents.
Die Pharmazie 1992;47(4):254-7.
1992: Ewa Chojnacka-Wójcik
Involvement of dopamine autoreceptors in the hypoactivity induced by 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in mice.
Polish journal of pharmacology and pharmacy 1992;44(2):135-46.
1992: A Kłodzińska; Ewa Chojnacka-Wójcik
Hyperthermia induced by m-trifluoromethylphenylpiperazine (TFMPP) or m-chlorophenylpiperazine (m-CPP) in heat-adapted rats.
Psychopharmacology 1992;109(4):466-72.
1992: Ewa Chojnacka-Wójcik; A Kłodzińska
Involvement of 5-HT1B receptors in the anticonflict effect of m-CPP in rats.
Journal of neural transmission. General section 1992;87(2):87-96.
1991: Ewa Chojnacka-Wójcik; E Tatarczyńska; K Gołembiowska; E Przegaliński
Involvement of 5-HT1A receptors in the antidepressant-like activity of gepirone in the forced swimming test in rats.
Neuropharmacology 1991;30(7):711-7.
1991: Ewa Chojnacka-Wójcik; E Przegaliński
Evidence for the involvement of 5-HT1A receptors in the anticonflict effect of ipsapirone in rats.
Neuropharmacology 1991;30(7):703-9.
1990: J L Mokrosz; M Dukat; S Misztal; Ewa Chojnacka-Wójcik; E Tatarczyńska
Structure-activity relationship studies of CNS agents. Part 1: The Free-Wilson analysis of acute toxicity and sedative effect of some 1,2,3,4-tetrahydro-beta-carbolines.
Die Pharmazie 1990;45(10):765-7.
1990: E Przegaliński; A M Ismaiel; Ewa Chojnacka-Wójcik; Boguslawa Budziszewska; E Tatarczyńska; E Błaszczyńska
The behavioural, but not the hypothermic or corticosterone, response to 8-hydroxy-2-(DI-n-propylamino)-tetralin, is antagonized by NAN-190 in the rat.
Neuropharmacology 1990;29(6):521-6.
1990: L Kaczmarek; P Nantka-Namirski; A Dereń; Ewa Chojnacka-Wójcik
Synthesis and pharmacological properties of 13H-naphtho[1',2':7,6] [1,4] diazepino[2,3-b] pyridines.
Polish journal of pharmacology and pharmacy 1990;42(2):165-75.
1990: Edmund Przegalinski; E Tatarczynska; Ewa Chojnacka-Wójcik
Antidepressant-like activity of ipsapirone, buspirone and gepirone in the forced swimming test in rats pretreated with proadifen.
Journal of psychopharmacology (Oxford, England) 1990;4(4):204-9.
1990: L Kaczmarek; P Nantka-Namirski; E Moryl; Ewa Chojnacka-Wójcik
Synthesis and pharmacological properties of some derivatives of 3-phenylimidazo[4,5-b]pyridine.
Polish journal of pharmacology and pharmacy 1990;42(1):79-84.
1990: A Kłodzińska; Ewa Chojnacka-Wójcik
Anorexia induced by M-trifluoromethylphenylpiperazine (TFMPP) in rats.
Polish journal of pharmacology and pharmacy 1990;42(1):13-7.
1989: P Bartyzel; S Misztal; E Tatarczyńska; Ewa Chojnacka-Wójcik
N-aminoalkylderivatives of 1,2,3,4-tetrahydro-beta-carboline-1-spiro-4'-N'- benzylpiperidine--a putative way to novel anxiolytic agents.
Polish journal of pharmacology and pharmacy 1989;41(5):495-504.
1989: B Wiczyńska; Lucyna Antkiewicz-Michaluk; Andrzej Pilc; Ewa Chojnacka-Wójcik; E Przegaliński
Antidepressant profile of 9-methyl-2[-3-(4-phenyl-1-piperazinylpropyl)]-1,2,3,4-tetrahydro-beta- carbolin-1-one (B-193).
Polish journal of pharmacology and pharmacy 1989;41(4):331-44.
1989: E Tatarczyńska; Ewa Chojnacka-Wójcik
Effects of 8-OH-DPAT and ipsapirone in the tests used for evaluation of the antidepressant action.
Polish journal of pharmacology and pharmacy 1989;41(4):321-30.
1989: B Wiczyńska; Ewa Chojnacka-Wójcik; A Rokosz-Pelc; H Mazela; E Przegaliński
Antiserotonin activity of 9-methyl-2-[3-(4-phenyl-1-piperazinylpropyl)]-1,2,3,4-tetrahydro -beta-carbolin-1-one (B-193).
Polish journal of pharmacology and pharmacy 1989;41(2):169-81.
1989: Edmund Przegalinski; E Tatarczynska; Ewa Chojnacka-Wójcik
Anticonflict effect of ipsapirone, buspirone and gepirone is not mediated by their common metabolite 1-(2-pyrimidinyl)piperazine.
Journal of psychopharmacology (Oxford, England) 1989;3(3):180-5.
1989: A Kłodzińska; T Jaros; Ewa Chojnacka-Wójcik; Jerzy Maj
Exploratory hypoactivity induced by m-trifluoromethylphenylpiperazine (TFMPP) and m-chlorophenylpiperazine (m-CPP).
Journal of neural transmission. Parkinson's disease and dementia section 1989;1(3):207-18.
1989: E Tatarczyńska; L Pawłowski; Ewa Chojnacka-Wójcik; Jerzy Maj
The central action of 1-(2-pyrimidinyl)-piperazine, an ipsapirone metabolite.
Polish journal of pharmacology and pharmacy 1989;41(1):51-61.
1988: S Misztal; M Dukat; Ewa Chojnacka-Wójcik; E Tatarczyńska
Synthesis and pharmacological properties of decahydro-5H-pyrido [1',2';5,1] imidazo [3,4-a]-beta-carbolines. Part II.
Polish journal of pharmacology and pharmacy 1988;40(4):429-33.
1988: S Misztal; Jan Boksa; Ewa Chojnacka-Wójcik; E Tatarczyńska; S Russeva
Synthesis and pharmacological properties of some 2-(3-aminopropionyl)- and 2-(3-aminopropyl)-1-(3-pyridyl)-1,2,3,4-tetrahydro-beta-carbolines.
Polish journal of pharmacology and pharmacy 1988;40(4):413-21.
1988: Jerzy Maj; Ewa Chojnacka-Wójcik; A Kłodzińska; A Dereń; E Moryl
Hypothermia induced by m-trifluoromethylphenylpiperazine or m-chlorophenylpiperazine: an effect mediated by 5-HT1B receptors?
Journal of neural transmission 1988;73(1):43-55.
1987: Jerzy Maj; Ewa Chojnacka-Wójcik; L Gancarczyk; E Tatarczyńska; B Wiczyńska
The anti-inflammatory and analgesic activity of N-3-pyridoyltryptamine (tryptamide).
Polish journal of pharmacology and pharmacy 1987;39(6):749-58.
1987: Alfred Zejc; Jolanta Obniska; Ewa Chojnacka-Wójcik; E Tatarczyńska; B Wiczyńska
Synthesis and anticonvulsant properties of N-methylpyridyl derivatives of m- and p-bromophenylsuccinimides.
Polish journal of pharmacology and pharmacy 1987;39(1):91-5.
1987: S Misztal; Jan Boksa; Ewa Chojnacka-Wójcik; E Tatarczyńska; A Lewandowska
Synthesis and pharmacological properties of some 2-substituted 1-(3-pyridyl)-1,2,3,4-tetrahydro-beta-carbolines.
Polish journal of pharmacology and pharmacy 1987;39(1):97-103.
1987: Jerzy Maj; Ewa Chojnacka-Wójcik; E Tatarczyńska; A Kłodzińska
Central action of ipsapirone, a new anxiolytic drug, on serotoninergic, noradrenergic and dopaminergic functions.
Journal of neural transmission 1987;70(1-2):1-17.
1986: S Misztal; Jan Boksa; Ewa Chojnacka-Wójcik; E Tatarczyńska; B Wiczyńska
1-Pyridyl-3,4-dihydro-beta-carbolines: synthesis and central action.
Polish journal of pharmacology and pharmacy 1986;38(5-6):555-65.
1986: W Zankowska-Jasińska; H Borowiec; M Burgieł; W Góralik; K Walocha; B Zaleska; Ewa Chojnacka-Wójcik; B Wiczyńska
Synthesis and pharmacological investigation of compounds containing a 2-thioxopyrrolidine-4,5-dione moiety.
Polish journal of pharmacology and pharmacy 1986;38(3):309-19.
1986: M Bała; A Naparzewska; Ewa Chojnacka-Wójcik
Analgesic and anti-inflammatory activity of 10-amino-11H-indeno [1,2-b] quinolin-11-one derivatives.
Polish journal of pharmacology and pharmacy 1986;38(2):221-7.
1986: Ewa Chojnacka-Wójcik; E Tatarczyńska; B Wiczyńska; A Lewandowska; E Przegaliński
The pharmacological profile of chlordesmethyldiazepam and other benzodiazepines.
Polish journal of pharmacology and pharmacy 1986;38(2):207-13.
1985: J Mirek; Ewa Chojnacka-Wójcik; E Tatarzyńska; B Wiczyńska
Synthesis of 3-phenyl-3-phenylthiopropionic acids, amides, amines and studies on their pharmacological properties.
Il Farmaco; edizione scientifica 1985;40(9):701-8.
1985: Jerzy Maj; Ewa Chojnacka-Wójcik; A Lewandowska; E Tatarczyńska
Central antiserotonin action of fluperlapine.
Polish journal of pharmacology and pharmacy 1985;37(4):517-24.
1985: Jerzy Maj; Ewa Chojnacka-Wójcik; A Lewandowska; E Tatarczyńska; B Wiczyńska
The central action of carbamazepine as a potential antidepressant drug.
Polish journal of pharmacology and pharmacy 1985;37(1):47-56.
1984: S Misztal; Jan Boksa; M Grabowska; Ewa Chojnacka-Wójcik; E Tatarczyńska
Synthesis and pharmacological properties of the products of condensation of tryptamine derivatives with pyridoxal.
Polish journal of pharmacology and pharmacy 1984;36(6):689-96.
1984: S Misztal; Ewa Chojnacka-Wójcik; P Bartyzel; A Moskal; E Tatarczyńska; B Wiczyńska; A Lewandowska
Synthesis and pharmacological properties of N-arylpiperazine-N'-alkylindanes.
Polish journal of pharmacology and pharmacy 1984;36(6):697-703.
1983: M Bała; M Michańków; Ewa Chojnacka-Wójcik; B Wiczyńska; E Tatarczyńska
Chemistry and anti-inflammatory activity of 10-methylamino-11H-indeno[1,2-b]quinolin-11-one (MB 432) derivatives.
Polish journal of pharmacology and pharmacy 1983;35(6):523-30.
1983: Ewa Chojnacka-Wójcik; A Naparzewska
Pharmacological properties of the antiinflammatory agent 10-methylamine-11-H-indeno-[1,2-b]quinolin-11-one (MB432).
Polish journal of pharmacology and pharmacy 1983;35(4):327-32.
1983: J Mirek; Z H Urbanek; L Burzyński; Ewa Chojnacka-Wójcik; B Wiczyńska
Synthesis and pharmacological properties of some 7H-[1] benzothiopyrano-[3,2-c] quinolin-7-ones.
Polish journal of pharmacology and pharmacy 1983;35(2):139-49.
1982: W Zankowska-Jasińska; M Burgieł; J Golus; A Kolasa; K Walocha; B Zaleska; Ewa Chojnacka-Wójcik; B Wiczyńska; E Tatarczyńska
Synthesis and pharmacological activity of some 2,3-dihydrofuran-2,3-dione derivatives.
Polish journal of pharmacology and pharmacy 1982;34(5-6):391-8.
1982: Ewa Chojnacka-Wójcik; A Naparzewska
Pharmacological properties of new 11H-indeno[1,2-b]-quinolin-11-one derivatives.
Polish journal of pharmacology and pharmacy 1982;34(5-6):357-63.
1980: S Misztal; P Bartyzel; Ewa Chojnacka-Wójcik; E Tatarczyńska; M Sypniewska
Synthesis and pharmacological properties of N-aroyl-beta-(1-indanyl)-ethylamines.
Polish journal of pharmacology and pharmacy 1980;32(4):577-85.